The Alliance for Cellular Signaling performed comprehensive experimental analyses of selected signaling systems and archives these data for the research community in the Data Center of the Signaling Gateway. Data are available for any purpose without obligation. All data are available for downloading, usually in the form of tab-delimited text files, for incorporation into standard data analysis programs (e.g., Excel). In many cases, files containing both raw data and minimally processed data are available for use, depending on the needs of the individual investigator.

Several experimental programs are currently underway and data is available from some of these. An initial ligand screen in splenic B cells has generated a large data set for analysis. Data is also available from an ongoing high-throughput yeast two-hybrid screen.

The AfCS Research Reports are an important complement to the public accessibility of data collected within our laboratories. Reports describe the purpose, design, and scope of specific experiments and provide the reader a basis for interpreting data. These reports have been edited and reviewed internally by the AfCS and are presented in the familiar environment of a traditional scientific journal. more

The AfCS is developing tools that may be of general interest to investigators within the signaling community.  We have begun to catalog many of our reagents including plasmids, antibodies, and subcellular localization markers for reference.

Antibody Database Web interface,  Report Phosphoprotein Database PDF,  Report Covalent Mod. Database PDF,  Report,  Excel Plasmid Database Web interface Signaling Maps Web interface

Protocols provide details of all procedures, solutions, and ligand preparations used within the AfCS laboratories. All protocols are edited and updated as necessary. These are available as PDF files for convenience. more