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Protein A000060
Author-entered Data
V1.0, Peer Reviewed
Published 5 Jan 2011
Automated Data
Not Reviewed
As At Publication
Automated Data
Not Reviewed
Latest from 6 Jun 2014

UCSD Nature Molecule Pages
Published online: 5 Jan 2011 | doi:10.1038/mp.a000060.01

14-3-3 zeta

Basis Sequence: Mouse

Andrea L Kasinski1, Haian Fu2

1Pharmacology, Emory University, GA 30322, US. 2Pharmacology, Emory University School of Medicine, GA 30322, US.

Correspondence should be addressed to Haian Fu: hfu@emory.edu


14-3-3 is a family of conserved phosphoserine/phosphothreonine binding proteins expressed in all eukaryotic cells. There are seven isoforms in mammals (β, ε, γ, η, σ, τ, ζ) that show a considerable degree of conservation of both structure and function. 14-3-3 proteins function as homo- and heterodimers in the cell and regulate diverse cellular processes through protein-protein interactions. These 14-3-3 regulated cellular processes include cell proliferation, cell cycle checkpoint control and suppression of the apoptotic signaling response. A prominent feature of 14-3-3 proteins is their ability to recognize phosphorylated serine or threonine within a defined motif of a client protein. Defined 14-3-3 recognition motifs include mode I (RSxpS/TxP), mode II (RxY/FxpS/TxP) and mode III (pS/pT (X1-2)-COOH). However, some 14-3-3/client interactions do not require client phosphorylation. Also, 14-3-3 isoforms themselves may be phosphorylated, which might affect client interaction. In many cases the interacting protein shows a certain preference for a distinct isoform(s) of 14-3-3. The ζ isoform (encoded by the Ywhaz gene) is widely expressed in tissues and interacts with a number of well documented client proteins. It modulates the kinase activity of Raf and the apoptotic activity of a subset of death promoting proteins including Bad and Ask1. Additionally, cellular levels of 14-3-3ζ are upregulated by the cell cycle regulating complex TSC1/TSC2, suggesting that 14-3-3ζ is directly linked to cell cycle regulation. The ζ isoform has also been implicated in various human diseases. The expression pattern of 14-3-3ζ has been associated with oncogenesis and increases with tumor progression in a number of cancers, and may also have a functional role in neurodegenerative diseases.

Alternative names for this molecule: 14-3-3 zeta; 14-3-3-zeta; 14-3-3delta (a phosphorylated form of 14-3-3 zeta); 14-3-3z; 14-3-3zeta; D14Abb1e; KCIP-1; Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; Ywhaz

Transition Network Graph This molecule exists in 80 states and has 80 transitions between these states.

[map] View high resolution network map