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Protein A003584
Author-entered Data
V1.0, Peer Reviewed
Published 17 May 2005
Automated Data
Not Reviewed
As At Publication
Automated Data
Not Reviewed
Latest from 6 Jun 2014

Rpn8

Basis Sequence: Mouse

Version 1.0, Peer Reviewed And Published 17 May 2005
Intepro Details retrieved 27 Apr 2005

doi:10.1038/mp.a003584.01  How to cite this Molecule Page

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Interpro Details
Database IDIPR000555 (Mov34_MPN_PAD1)
NameMov34/MPN/PAD-1
Abstract

Members of this family are found in proteasome regulatory subunits, eukaryotic initiation factor 3 (eIF3) subunits and regulators of transcription factors. This family is also known as the MPN domain and PAD-1-like domain . It has been shown that this domain occurs in prokaryotes .

Mov34 proteins act as the regulatory subunit of the 26 proteasome, which is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of this domain is unclear, but it is found in the N-terminus of the proteasome regulatory subunits, eukaryotic initiation factor 3 (eIF3) subunits and regulators of transcription factors.

A number of the proteins associated with this family belong to MEROPS peptidase family M67 (clan M-). This includes the Poh1 peptidase of Saccharomyces cerevisiae which is a component of the 19S proteasome regulatory particle.

Referenced By Molecule Page ProteinYes
Computational matchYes
Interpro TypeFamily
Gene Ontology-
Signatures & LinksIPB000555 (BLOCKS)
PRX001314 (COMe)
M67 (MEROPS)
PF01398 (PANDIT)
PF01398 (PFAM), Mov34, num proteins = 328
PS50249 (PREFILE), MPN_DOMAIN, num proteins = 210
SM00232 (SMART), JAB_MPN, num proteins = 303
Structure References-