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Protein A003584
Author-entered Data
V1.0, Peer Reviewed
Published 17 May 2005
Automated Data
Not Reviewed
As At Publication
Automated Data
Not Reviewed
Latest from 6 Jun 2014

Rpn8

Basis Sequence: Mouse

Version 1.0, Peer Reviewed And Published 17 May 2005
Intepro Details retrieved 27 Apr 2005

doi:10.1038/mp.a003584.01  How to cite this Molecule Page

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Interpro Details
Database IDIPR003639 (Mov34-1)
NameMov34-1
Abstract

This domain is associated with a number of different proteins, these include:

  • Eukaryotic translation initiation factor 3 subunit 3 (eIF-3 gamma).
  • Proteasome regulatory subunit RPN11 (MPR1 protein).
  • MOV34 isolog (COP9 subunit 6).
  • COP9 signalosome complex subunit 5 (CSN complex subunit 5) (SGN5).

Mov34 proteins act as the regulatory subunit of the 26 proteasome, which is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of this domain is unclear, but it is also found in the N-terminus of the proteasome regulatory subunits, eukaryotic initiation factor 3 (eIF3) subunits and regulators of transcription factors.

A number of the proteins in this family are metallopeptidases or non-peptidase homologues belonging to MEROPS peptidase family M67 (clan M-).

Referenced By Molecule Page ProteinYes
Computational matchNo
Interpro TypeDomain
Gene Ontology-
Signatures & LinksM67 (MEROPS)
PD363422 (PRODOM), Mov34-1, num proteins = 150
Structure References-