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Protein A003584
Author-entered Data
V1.0, Peer Reviewed
Published 17 May 2005
Automated Data
Not Reviewed
As At Publication
Automated Data
Not Reviewed
Latest from 6 Jun 2014

Rpn8

Basis Sequence: Mouse

Latest intepro details retrieved 6 Jun 2014

doi:10.1038/mp.a003584.01  How to cite this Molecule Page

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Interpro Details
Database IDIPR000555 (JAB_MPN_dom)
NameJAB/MPN domain
Abstract

This domain is known as the MPN domain [], PAD-1-like domain [], JABP1 domain [] or JAMM domain []. Proteins with this domain include proteasome regulatory subunits, eukaryotic initiation factor 3 (eIF3) subunits and regulators of transcription factors. They are metalloenzymes that function as the ubiquitin isopeptidase/ deubiquitinase in the ubiquitin-based signaling and protein turnover pathways in eukaryotes []. Versions of the domain in prokaryotic cognates of the ubiquitin-modification pathway are predicted to have a similar role [].

Referenced By Molecule Page ProteinYes
Computational matchYes
Interpro TypeDomain
Gene OntologyGO:0005515, protein binding, Molecular Function
Signatures & LinksIPB000555 (BLOCKS)
PRX001314 (COMe)
PF01398 (PANDIT)
PF01398 (PFAM), JAB, num proteins = 4233
SM00232 (SMART), JAB_MPN, num proteins = 7722
Structure References
c.97.3.1 (SCOP)3.40.140.10 (CATH)1oi0 (PDB)1r5x (PDB)