Protein A000111

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Published 11 Dec 2003

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UCSD Nature Molecule Pages
Published online: 11 Dec 2003 | doi:10.1038/mp.a000111.01

Adenylyl cyclase type 2

Ron Taussig¹

¹Pharmacology, UT Southwestern Medical Center, TX 75390-9041, US.

Correspondence should be addressed to Ron Taussig: ron.taussig@UTSouthwestern.edu

All membrane-bound mammalian adenylyl cyclases catalyze the conversion of MgATP to cyclic AMP and pyrophosphate. Adenylyl cyclase type 2 (ACII) is the prototype member of the subfamily of adenylyl cyclases that are conditionally activated by G protein β/γ subunits. ACII is stimulated by Gα_s and forskolin. In the presence of Gα_s-stimulation, G protein β/γ subunits (released from G_i heterotrimers) further stimulate the activity of the enzyme. Gα_s has been shown to be constitutively palmitoylated at position 2, and reversibly palmitoylated at position 3; there is no reported difference between the singly versus doubly palmitoylated Gα_s with respect to the activation of acenylyl cyclases.

Alternative names for this molecule: AC2; Adcy2; ADCY2; Adenylate cyclase 2 (brain); Adenylate cyclase type II; Adenylcyclase type II; Adenylyl cyclase type 2; ATP pyrophosphate-lyase type II; HBAC2

This molecule exists in 12 states, has 26 transitions between these states and has 12 enzyme functions.

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