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| Domain Map |
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| Other Representations |
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| Matching InterPro Records |
| Database ID | IPR000663 (Natr_peptide) |
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| Name | Natriuretic peptide |
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| Abstract | Atrial natriuretic peptides (ANPs) are vertebrate hormones that play an important role in the control of
cardiovascular homeostatis, and sodium and water balance in general [].
There are different NPs that vary in length but share a common core. All are processed from a single precursor.
A disulphide bond resident in the C-terminal section is required for full activity of atriopeptins. The family
of NPs includes structurally-related peptides that elicit similar pharmacological spectra. Amongst these are
brain natriuretic peptide (BNP); C-type natriuretic peptide (CNP); ventricular natriuretic peptide (VNP)
[]; and green mamba natriuretic peptide (DNP) [].
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| Referenced By Molecule Page Protein | Yes |
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| Interpro Type | Family |
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| Gene Ontology | GO:0005576, extracellular region, Cellular Component
GO:0005179, hormone activity, Molecular Function |
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| Signatures & Links | IPB000663 (BLOCKS)
PS00263 (MSDsite)
PF00212 (PANDIT)
PF00212 (PFAM), ANP, num proteins = 217
PR00710 (PRINTS), NATPEPTIDES, num proteins = 129
PS00263 (PROSITE), NATRIURETIC_PEPTIDE, num proteins = 199
PDOC00236 (PROSITEDOC)
SM00183 (SMART), NAT_PEP, num proteins = 217 |
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| Structure References | |
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| Database ID | IPR002407 (At__natriurtcpep) |
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| Name | Natriuretic peptide, atrial type |
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| Abstract | Atrial natriuretic peptides (ANPs) are vertebrate hormones that play an important role in the control of
cardiovascular homeostatis, and sodium and water balance in general [].
There are different NPs that vary in length but share a common core. All are processed from a single precursor.
A disulphide bond resident in the C-terminal section is required for full activity of atriopeptins. The family
of NPs includes structurally-related peptides that elicit similar pharmacological spectra. Amongst these are
brain natriuretic peptide (BNP); C-type natriuretic peptide (CNP); ventricular natriuretic peptide (VNP)
[]; and Dendroaspis angusticeps (Eastern green mamba) natriuretic peptide (DNP) []
Atrial natriuretic factor (ANF) is a potent vasoactive substance synthesized in mammalian atria and is thought to play a key role in cardiovascular homeostasis. It has a cGMP-stimulating activity.
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| Referenced By Molecule Page Protein | Yes |
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| Interpro Type | Family |
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| Gene Ontology | GO:0005576, extracellular region, Cellular Component
GO:0005179, hormone activity, Molecular Function |
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| Signatures & Links | IPB002407 (BLOCKS)
PR00711 (PRINTS), ANATPEPTIDE, num proteins = 54 |
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| Structure References | |
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| Database ID | IPR002408 (Br__natriurtcpep) |
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| Name | Natriuretic peptide, brain type |
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| Abstract | Atrial natriuretic peptides (ANPs) are vertebrate hormones that play an important role in the control of
cardiovascular homeostatis, and sodium and water balance in general [].
There are different NPs that vary in length but share a common core. All are processed from a single precursor.
A disulphide bond resident in the C-terminal section is required for full activity of atriopeptins. The family
of NPs includes structurally-related peptides that elicit similar pharmacological spectra. Amongst these are
brain natriuretic peptide (BNP); C-type natriuretic peptide (CNP); ventricular natriuretic peptide (VNP)
[]; and Dendroaspis angusticeps (Eastern green mamba) natriuretic peptide (DNP) []
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| Referenced By Molecule Page Protein | No |
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| Interpro Type | Family |
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| Gene Ontology | GO:0005576, extracellular region, Cellular Component
GO:0005179, hormone activity, Molecular Function |
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| Signatures & Links | IPB002408 (BLOCKS)
PR00712 (PRINTS), BNATPEPTIDE, num proteins = 72 |
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| Structure References | - |
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| Matching Pfam / SMART Records |
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| Database ID | PF00212 (ANP) |
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| Description | Atrial natriuretic peptide |
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| Score | 41.7 |
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| E Value | 6.80E-11 |
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| Num Matches | 1 |
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| Referenced By Molecule Page Protein | Yes |
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| Match Num | Sequence Coords | Model Coords | Score | E Value |
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| 1 | 113-145 | 9-33 | 40.9 | 1.20E-10 |
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| Database ID | SM00183 (NAT_PEP) |
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| Description | Natriuretic peptide |
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| Score | 40.8 |
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| E Value | 4.20E-10 |
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| Num Matches | 1 |
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| Referenced By Molecule Page Protein | Yes |
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| Match Num | Sequence Coords | Model Coords | Score | E Value |
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| 1 | 122-145 | 1-24 | 40.8 | 4.20E-10 |
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| Matching PRINTS Records |
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| Database ID | PR00711 (ANATPEPTIDE) |
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| Description | Atrial natriuretic peptide signature |
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| PP Value | 3.70E-87 |
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| E Value | 8.10E-82 |
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| Num Matches | 7/7 |
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| Referenced By Molecule Page Protein | Yes |
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| Significant Match | Yes |
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| Motif Num | Sequence Coords | PF Score | P Value | Motif Length | Motif Sequence |
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| 1 | 10-28 | 667.0 | 4.53E-13 | 19 | FFLVLAFWLPGHIGANPVY |
| 2 | 31-49 | 863.0 | 1.11E-12 | 19 | VSNTDLMDFKNLLDHLEEK |
| 3 | 50-68 | 788.0 | 7.89E-12 | 19 | MPVEDEVMPPQALSEQTEE |
| 4 | 71-88 | 869.0 | 3.53E-12 | 18 | AALSSLPEVPPWTGEVNP |
| 5 | 91-107 | 649.0 | 5.13E-9 | 17 | RDGSASRRSPWDPSDRS |
| 6 | 108-126 | 803.0 | 6.25E-15 | 19 | ALLKSKLRALLAGPRSLRR |
| 7 | 127-149 | 1219.0 | 8.19E-18 | 23 | SSCFGGRIDRIGAQSGLGCNSFR |
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| Database ID | PR00710 (NATPEPTIDES) |
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| Description | Natriuretic peptide family signature |
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| PP Value | 3.60E-12 |
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| E Value | 5.30E-6 |
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| Num Matches | 2/2 |
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| Referenced By Molecule Page Protein | Yes |
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| Significant Match | Yes |
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| Motif Num | Sequence Coords | PF Score | P Value | Motif Length | Motif Sequence |
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| 1 | 126-135 | 370.0 | 1.71E-5 | 10 | RSSCFGGRID |
| 2 | 135-144 | 425.0 | 2.09E-7 | 10 | DRIGAQSGLG |
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| Database ID | PR00712 (BNATPEPTIDE) |
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| Description | Brain natriuretic peptide signature |
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| PP Value | 1.50E-12 |
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| E Value | 1.70E-6 |
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| Num Matches | 2/5 |
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| Referenced By Molecule Page Protein | No |
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| Significant Match | Yes |
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| Motif Num | Sequence Coords | PF Score | P Value | Motif Length | Motif Sequence |
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| 4 | 127-137 | 456.0 | 1.75E-6 | 11 | SSCFGGRIDRI |
| 5 | 137-150 | 405.0 | 8.45E-7 | 14 | IGAQSGLGCNSFRY |
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