UCSD Nature Molecule Pages
Published online: 3 Nov 2006 | doi:10.1038/mp.a000275.01
Angiotensin receptor 1a
Basis Sequence: Mouse
Noriko Makita1, Toshiro Fujita2, Taroh Iiri1
1Endocrinology and Nephrology, The University of Tokyo, 113-8655, JP. 2Endocrinology and Nephrology, The University of Tokyo, Tokyo 113-8655, JP.
Correspondence should be addressed to Taroh Iiri: email@example.com
Two major subtypes of angiotensin II (Ang II) receptors have been identified, namely type 1 (AT1) and type 2 (AT2). AT1 has a central function in the physiological actions of Ang II, such as the regulation of arterial blood pressure, electrolyte and water balance, sympathetic nervous activity, thirst, hormone secretion and renal function, through its actions on cardiovascular, renal, neuronal, endocrine, hepatic, and other target cells. AT1 is also believed to have an important pathophysiological function in many diseases, including cardiac hypertrophy, myocardial infarction, hypertension and athelosclerosis, lending support to the notion that AT1 mediates most of the physiological and pathophysiological actions of Ang II and that this subtype of the receptor predominantly mediates the actions of Ang II on the cardiovascular system. The main functions of AT1 at the molecular level are activation of the Gq,Gi/o and G12/13 proteins, activation of tyrosine or serine/threonine kinases and phospholipase C, D, and A2, activation of ion channels, and modulation of mitogen-activated protein kinases (MAPKs). In many organ systems, the receptor activates Rho and other small G proteins and reactive oxygen species (ROS). It has recently been reported that β-arrestins act as positive signal transducers of AT1 signaling, including for the activation of MAPKs, in a temporally and spatially specific manner. Two distinct subtypes of AT1 receptors (AT1a and AT1b) that are 95% identical in their amino acid sequences have been identified, but only in the rat and mouse among mammals. Although the two subtypes exhibit similar ligand-binding and signal transduction activities, they differ in their tissue distribution and transcriptional regulation.
Alternative names for this molecule:
AG2S; Agtr-1a; Agtr1; Agtr1a; Angiotensin II receptor, type 1a; Angiotensin receptor 1; Angiotensin receptor 1a; Angiotensin(1A) receptor; Angtr-1a; AT(1A) receptor; AT1; AT1A receptor; AT1AR; AT2R1; AT2R1A; Type-1A angiotensin II receptor