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Protein A002040
Author-entered Data
V1.0, Peer Reviewed
Published 16 Nov 2009
Automated Data
Not Reviewed
As At Publication
Automated Data
Not Reviewed
Latest from 6 Jun 2014

UCSD Nature Molecule Pages
Published online: 16 Nov 2009 | doi:10.1038/mp.a002040.01

Rgs1

Basis Sequence: Mouse

Hyeseon Cho1, John H Kehrl1

1Laboratory of Immunoregulation, National Institutes of Health, MD 20892, US.

Correspondence should be addressed to John H Kehrl: jkehrl@niaid.nih.gov


RGS1 is a GTPase activating protein (GAP) for Gαi and Gαq and a member of the R4 family of RGS proteins. Transient transfection assays have shown that RGS1 attenuates G protein-coupled receptor (GPCR)-mediated signaling pathways. Studies performed using Rgs1-deficient mouse immune cells, or cells with reduced expression of human RGS1, show the expected enhancement in GPCR signaling. By contrast, RGS1, along RGS3 and RGS4, is reported to dramatically accelerate the activation kinetics of Gβγ-activated inwardly rectifying K+ channels in reconstituted Xenopus oocytes. Human RGS1 was first identified as a novel gene by subtractive cDNA cloning of activated B cells against activated T lymphocytes, and was highly expressed in peripheral blood mononuclear cells from a patient with B-cell acute lymphocytic leukemia. RGS1 expression is modulated in a variety of patho-physiological conditions including cancer, innate immune response through Toll-like receptor activation, and infection. Rgs1-targeted mice show abnormal B-cell and dendritic cell responses to chemokines, abnormal immune tissue architecture and defective lymphocyte trafficking.

Alternative names for this molecule: 1R20; BL34; IER1; IR20; Regulator of G protein signaling 1; Rgs1

Transition Network Graph This molecule exists in 14 states and has 13 transitions between these states.

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