tooltip layer (initially hidden)
signaling gateway home
Protein A003867
Author-entered Data
V1.0, Peer Reviewed
Published 7 Dec 2007
Automated Data
Not Reviewed
As At Publication
Automated Data
Not Reviewed
Latest from 6 Jun 2014

UCSD Nature Molecule Pages
Published online: 7 Dec 2007 | doi:10.1038/mp.a003867.01

RdgB beta

Basis Sequence: Mouse

Justin Hsuan1, Mark G Waugh2

1Department of Medicine, University College London, England NW3 2PF, UK. 2Centre for Molecular Cell Biology, Department of Medicine, University College London, England NW3 2PF, UK.

Correspondence should be addressed to Justin Hsuan: j.hsuan@medsch.ucl.ac.uk


Pitpnc1 (Phosphatidylinositol transfer protein, cytoplasmic 1; also known as RdgBβ) was originally identified by means of its sequence similarity to the phosphatidylinositol transfer protein (PITP) family, whose proteins are encoded by five different genes in mammals: PITPα/Pitpna, PITPβ/Pitpnb, rdgBβ/Pitpnc1, Nir2/rdgB1/Pitpnm1, and Nir3/rdgB2/Pitpnm2. Family members are characterized by a single PITP domain, which can transfer phosphatidylinositol or phosphatidylcholine between lipid membranes. Although functional degeneracy of different family members has been found by using recombinant protein overexpression in vitro or in vivo, the existence of physiological differences in expression and subcellular localization as well as differences in mutant phenotypes indicate specificity of function in vivo. However, molecular mechanisms underlying differential regulation, localization, and function remain largely unknown for most isoforms, including Pitpnc1.

Alternative names for this molecule: Cytoplasmic phosphatidylinositol transfer protein 1; Diabetic nephropathy-related protein; Dnr411; M-rdgB beta; mM-rdgBbeta; MrdgBbeta; Phosphatidylinositol transfer protein, cytoplasmic 1; Pitpnc1; RdgB beta; RdgB-beta; RDGBB; RDGBB1; RdgBbeta; Retinal degeneration B beta; Retinal degeneration B homolog beta

Transition Network Graph This molecule exists in 3 states, has 3 transitions between these states and has 2 transporter functions.

[map] View high resolution network map