UCSD Nature Molecule Pages
Published online: 7 Dec 2007 | doi:10.1038/mp.a003867.01
Basis Sequence: Mouse
Justin Hsuan1, Mark G Waugh2
1Department of Medicine, University College London, England NW3 2PF, UK. 2Centre for Molecular Cell Biology, Department of Medicine, University College London, England NW3 2PF, UK.
Correspondence should be addressed to Justin Hsuan: email@example.com
Pitpnc1 (Phosphatidylinositol transfer protein, cytoplasmic 1; also known as RdgBβ) was originally identified by means of its sequence similarity to the phosphatidylinositol transfer protein (PITP) family, whose proteins are encoded by five different genes in mammals: PITPα/Pitpna, PITPβ/Pitpnb, rdgBβ/Pitpnc1, Nir2/rdgB1/Pitpnm1, and Nir3/rdgB2/Pitpnm2. Family members are characterized by a single PITP domain, which can transfer phosphatidylinositol or phosphatidylcholine between lipid membranes. Although functional degeneracy of different family members has been found by using recombinant protein overexpression in vitro or in vivo, the existence of physiological differences in expression and subcellular localization as well as differences in mutant phenotypes indicate specificity of function in vivo. However, molecular mechanisms underlying differential regulation, localization, and function remain largely unknown for most isoforms, including Pitpnc1.
Alternative names for this molecule:
Cytoplasmic phosphatidylinositol transfer protein 1; Diabetic nephropathy-related protein; Dnr411; M-rdgB beta; mM-rdgBbeta; MrdgBbeta; Phosphatidylinositol transfer protein, cytoplasmic 1; Pitpnc1; RdgB beta; RdgB-beta; RDGBB; RDGBB1; RdgBbeta; Retinal degeneration B beta; Retinal degeneration B homolog beta