Rapidly accumulating AfCS data
increasingly reveals unexpected patterns, phenotypes, and effects, many
of which open avenues to interesting hypotheses and experiments that
exceed the capacities of AfCS laboratories. The Center is designed to
promote discussion and exploration of AfCS data by the
scientific community, AfCS scientists, and participating investigators
by highlighting interesting data found within the DataCenter. You are
encouraged to browse the proposals and discussions listed, and also to
develop experiments that will support or disprove any of these
hypotheses.
Listed below are hypotheses that have been proposed. The title
links to details of the hypothesis including an abstract, specific observations, sources of data,
possible experiments, and discussion of the topic.
| |
Title of Hypothesis |
Author |
Entry Date |
Comments |
| 1 |
G-Alpha-i2 (Gai2) RNAi with shRNA ‘C’ Yields an Off-Target Phenotype Despite Greater Sequence Specificity
|
Rebres, R. |
22 MAR 2005 |
(0) |
| 2 |
Attenuation of Interferon-Mediated STAT Phosphorylation by TLR Ligands in RAW264.7 Cells
|
Fraser, I. |
18 MAR 2005 |
(0) |
| 3 |
An Explanation for the Dependence of C5a-Induced Calcium and Phospho-AKT Phenotypes on Choice of G-Alpha-i2 RNAi Sequence
|
Sinkovits, R. |
18 FEB 2005 |
18 MAR 2005 (1) |
| 4 |
Paradoxical Effects of Sphingosine-1-Phosphate on AKT
|
Cantley, L. |
06 FEB 2005 |
07 APR 2005 (1) |
| 5 |
Specific Adenylyl Cyclase Isoforms Mediate Synergistic Activation of cAMP Accumulation by Isoproterenol and GPCR Ligands That Act on Gq /11 and Gi
|
Bourne, H. |
28 JAN 2005 |
03 MAY 2005 (1) |
| 6 |
Synergistic Calcium Response with C5a and UDP in RAW 264.7 Cells
|
Sternweis, P. |
28 JAN 2005 |
(0) |
| 7 |
IP3-Independent Mobilization of Intracellular Calcium by LPA
|
DeCamp, D. |
14 DEC 2004 |
(0) |
| 8 |
Sphingosine-1-Phosphate Enhances Stimulation of cAMP by Isoproterenol in RAW264.7 Cells
|
Lin, K. |
14 DEC 2004 |
10 MAR 2005 (1) |
| 9 |
Toll Receptor Ligands Inhibit Interferon-Mediated STAT Phosphorylation
|
Mumby, S. |
23 AUG 2004 |
22 APR 2005 (1) |
| 10 |
Calcium-Modulating Cyclophilin Ligand Binds to Ryanodine Receptor and CaMKII
|
Sambrano, G. |
20 AUG 2004 |
(0) |
