UCSD-Nature Signaling Gateway


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The Signaling Gateway

The Signaling Gateway comprises three main sections: The Molecule Pages, Signaling Update and the Data Center. Each section is tailored to meet a different need, as described below. If you have any feedback or questions on this project, please contact us.

The Molecule Pages

This is a database of key facts about proteins involved in cellular signaling. It currently covers over 4,000 proteins. For each of these, the database already provides a large amount of 'automated' data, collected from numerous other online resources and updated monthly. These data include names, synonyms, sequence information, biophysical properties, domain and motif information, protein family details, structure and gene data, the identities of orthologs and paralogs, and BLAST results.

There are over 300 comprehensive expert-authored full Molecule Pages, which include a review of the molecule, highly structured information on protein states, interactions, subcellular localisation and function, together with references to the relevant literature. More expert-authored Molecule Pages are being published every day. These entries are peer-reviewed by anonymous experts invited by the Nature Publishing Group editorial team and will be formally citable using digital object identifiers.

For over 800 proteins we also provide 'Mini Molecule Page' summaries composed by invited expert authors.

Signaling Update

Cell signaling is at the core of most biological processes and represents a vibrant area of research. Signaling Update provides a one-stop overview of what's happening in cell signaling for the specialist researcher and the interested non-specialist alike.

At Signaling Update you'll find the following:

Updates: Short, accessible 'Highlights' summarize and contextualize must-read papers from across the literature. The articles add background and context to summaries of primary research related to cell signaling.
Research Library: Categorizes and provides access to all recent signaling-related research published in Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.
Featured Article: Every week we showcase new articles from Nature Publishing Group journals. Free full text access is maintained for three months.
News: Links to signaling related news from the pages of Nature Publishing Group journals.
Nature Jobs: Browse signaling related jobs by category. You'll find the jobs link on the left-hand side of the Signaling Update homepage.
Conference Calendar: A comprehensive guide to the main events of the signaling calendar. Meetings can be viewed either chronologically or alphabetically.
You can also register for the weekly Signaling Update e-alert and receive the latest signaling developments straight to your inbox.

Data Center

One of the major goals of the Alliance for Cellular Signaling project was to provide data derived from comprehensive experimentation in signal transduction to the signaling community at large. These data sets are made accessible here, in a section that aims to serve as an archived data warehouse for all experimental results.

B-cell ligand screen: The Ligand Screen is a strategy for detecting the inputs and combinations of inputs that are most relevant to regulation of the behavior of the cells chosen as our experimental targets. The goals were (1) to determine which ligands give functionally unique responses and (2) to determine which combinations of ligands interact in ways that are not simply energetically additive.
Y2H screen: Identification of protein-protein interactions and the changes in such interactions that result from ligand binding or covalent modification are clearly central to understanding the mechanisms of signal transduction and establishing intracellular signaling networks. The AfCS arranged a collaboration with Myriad Genetics to perform large-scale yeast two-hybrid screens.

In this section, you'll also find the AfCS Protocols and the AfCS Research Reports, an important complement to the public accessibility of data collected within AfCS laboratories.