UCSD-Nature Signaling Gateway


site guide

The Signaling Gateway

The Signaling Gateway comprises three main sections: The Molecule Pages, Signaling Update and the Data Center. Each section is tailored to meet a different need, as described below. If you have any feedback or questions on this project, please contact us.

The Molecule Pages

Molecule Pages are individual components of a database of key facts about proteins involved in cellular signaling. The database currently covers nearly 4,000 proteins. For each of these, a large amount of 'automated' data, collected from numerous other online resources and updated monthly, is available. These data include names, synonyms, sequence information, biophysical properties, domain and motif information, protein family details, structure and gene data, the identities of orthologs and paralogs, and BLAST results.

We have published over 500 comprehensive, expert-authored full Molecule Pages. Published Molecule Pages include a review article focused on the molecule and a complementary database of highly structured information on protein interactions, subcellular localizations and biochemical functions with references to the relevant literature. New expert-authored Molecule Pages are being published each week. These entries are peer-reviewed by anonymous experts invited by the Nature Publishing Group editorial team and will be formally citable using digital object identifiers.

Our getting started guide is available for download as a PDF. The guide provides a quick overview of the anatomy of a published Molecule Page, and highlights the wealth of data that are available for all 4,000 Molecule Pages in the database.

Signaling Update

Cell signaling is at the core of most biological processes and represents a vibrant area of research. Signaling Update provides a one-stop overview of what's happening in cell signaling for the specialist researcher and the interested non-specialist alike.

At Signaling Update you'll find the following:

Updates: Short, accessible highlights summarize and contextualize must-read papers from across the literature. The articles add background and context to summaries of primary research related to cell signaling.
Research Library: Categorizes and provides access to all recent signaling-related research published in Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.
Featured Article: Every week we showcase new articles from Nature Publishing Group journals. Free full text access is maintained for three months.
News: Links to signaling related news from the pages of Nature Publishing Group journals.
Nature Jobs: Browse signaling related jobs by category. You'll find the jobs link on the left-hand side of the Signaling Update homepage.
Conference Calendar: A comprehensive guide to the main events of the signaling calendar. Meetings can be viewed either chronologically or alphabetically.
You can also register for the weekly Signaling Update e-alert and receive the latest signaling developments straight to your inbox. An RSS feed is also available.

Data Center

One of the major goals of the Alliance for Cellular Signaling project was to provide data derived from comprehensive experimentation in signal transduction to the signaling community at large. These data sets are made accessible here, in a section that aims to serve as an archived data warehouse for all experimental results.

B-cell ligand screen: The Ligand Screen is a strategy for detecting the inputs and combinations of inputs that are most relevant to regulation of the behavior of the cells chosen as our experimental targets. The goals were (1) to determine which ligands give functionally unique responses and (2) to determine which combinations of ligands interact in ways that are not simply energetically additive.
Y2H screen: Identification of protein-protein interactions and the changes in such interactions that result from ligand binding or covalent modification are clearly central to understanding the mechanisms of signal transduction and establishing intracellular signaling networks. The AfCS arranged a collaboration with Myriad Genetics to perform large-scale yeast two-hybrid screens.

In this section, you'll also find the AfCS Protocols and the AfCS Research Reports, an important complement to the public accessibility of data collected within AfCS laboratories. You can also view the AfCS guided tour.