The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.
Click here for free access to the 'Featured Articles' section, with new articles every week.
review article EFFICACY AT G-PROTEIN-COUPLED RECEPTORS
Terry Kenakin Nature Reviews Drug Discovery 1, 103–110
(February 2002); doi:10.1038/nrd722
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review article APOPTOSIS-BASED THERAPIES
John C. Reed Nature Reviews Drug Discovery 1, 111–121
(February 2002); doi:10.1038/nrd726
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review article DEADLY ENCOUNTER: UBIQUITIN MEETS APOPTOSIS
Veronika Jesenberger and Stefan Jentsch Nature Reviews Molecular Cell Biology3, 112–121
(February 2002); doi:10.1038/nrm731
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review article PHYTOCHROME PHOTOSENSORY SIGNALLING NETWORKS
Peter H. Quail Nature Reviews Molecular Cell Biology3, 85–93
(February 2002); doi:10.1038/nrm728
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review article SECRETORY LYSOSOMES
Emma J. Blott and Gillian M. Griffiths Nature Reviews Molecular Cell Biology3, 122–131
(February 2002); doi:10.1038/nrm732
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review article SPECIALIZATION OF TUMOUR VASCULATURE
Erkki Ruoslahti Nature Reviews Cancer2, 83–90
(February 2002); doi:10.1038/nrc724
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review article ROLE OF INTEGRINS IN CELL INVASION AND MIGRATION
John D. Hood and David A. Cheresh Nature Reviews Cancer2, 91–100
(February 2002); doi:10.1038/nrc727
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review article ENDOCRINE-RESPONSIVE BREAST CANCER AND STRATEGIES FOR COMBATING RESISTANCE
Simak Ali and R. Charles Coombes Nature Reviews Cancer2, 101–112
(February 2002); doi:10.1038/nrc721
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review article RHO-GTPASES AND CANCER
Erik Sahai and Christopher J. Marshall Nature Reviews Cancer2, 133–142
(February 2002); doi:10.1038/nrc725
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review article ESTABLISHMENT OF VERTEBRATE LEFT-RIGHT ASYMMETRY
Hiroshi Hamada, Chikara Meno, Daisuke Watanabe and Yukio Saijoh Nature Reviews Genetics 3, 103–113
(February 2002); doi:10.1038/nrg732
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review article LIPID RAFTS AND B-CELL ACTIVATION
Susan K. Pierce Nature Reviews Immunology 2, 96–105
(February 2002); doi:10.1038/nri726
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review article CHEMOKINE RECEPTORS: MULTIFACETED THERAPEUTIC TARGETS
Amanda E. I. Proudfoot Nature Reviews Immunology 2, 106–115
(February 2002); doi:10.1038/nri722
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review article THE B7-CD28 SUPERFAMILY
Arlene H. Sharpe and Gordon J. Freeman Nature Reviews Immunology 2, 116–126
(February 2002); doi:10.1038/nri727
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review article C-TYPE LECTIN RECEPTORS ON DENDRITIC CELLS AND LANGERHANS CELLS
Carl G. Figdor, Yvette van Kooyk and Gosse J. Adema Nature Reviews Immunology 2, 77–84
(February 2002); doi:10.1038/nri723
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review article ION CHANNEL STRUCTURE: THE STRUCTURE AND FUNCTION OF GLUTAMATE RECEPTOR ION CHANNELS
Dean R. Madden Nature Reviews Neuroscience 3, 91–101
(February 2002); doi:10.1038/nrn725
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review article ION CHANNEL STRUCTURE: EMERGING STRUCTURE OF THE NICOTINIC ACETYLCHOLINE RECEPTORS
Arthur Karlin Nature Reviews Neuroscience 3, 102–114
(February 2002); doi:10.1038/nrn731
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review article ION CHANNEL STRUCTURE: POTASSIUM CHANNEL STRUCTURES
Senyon Choe Nature Reviews Neuroscience 3, 115–121
(February 2002); doi:10.1038/nrn727
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letter Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice
Toshimasa Yamauchi, Yuichi Oike, Junji Kamon, Hironori Waki, Kajuro Komeda, Atsuko Tsuchida, Yukari Date, Meng-Xian Li, Hiroshi Miki, Yasuo Akanuma, Ryozo Nagai, Satoshi Kimura, Takeyori Saheki, Masamitsu Nakazato, Takeshi Naitoh, Kenichi Yamamura and Takashi Kadowaki Nature Genetics 30, 221–226
(February 2002); doi:10.1038/ng829
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news and views An essential link to mammary cancer?
Sibylle Tonko-Geymayer and Wolfgang Doppler Nature Medicine 8, 108–110
(February 2002); doi:10.1038/nm0202-108
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commentary Limits to lifespan
Alison C. Lloyd Nature Cell Biology4, E25
(February 2002); doi:10.1038/ncb0202-e25
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news and views Formin' actin filament bundles
Daniel J. Lew Nature Cell Biology4, E29
(February 2002); doi:10.1038/ncb0202-e29
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article Formins direct Arp2/3-independent actin filament assembly to polarize cell growth in yeast
Marie Evangelista, David Pruyne, David C. Amberg, Charles Boone and Anthony Bretscher Nature Cell Biology4, 32–41
(January 2002); doi:10.1038/ncb718
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article Yeast formins regulate cell polarity by controlling the assembly of actin cables
Isabelle Sagot, Saskia K. Klee and David Pellman Nature Cell Biology4, 42–50
(January 2002); doi:10.1038/ncb719
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news and views Hip, Hip, Hippi!
Valerie Ferrier Nature Cell Biology4, E30
(February 2002); doi:10.1038/ncb0202-e30
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article Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi
François G. Gervais, Roshni Singaraja, Steven Xanthoudakis, Claire-Anne Gutekunst, Blair R. Leavitt, Martina Metzler, Abigail S. Hackam, John Tam, John P. Vaillancourt, Vicky Houtzager, Dita M. Rasper, Sophie Roy, Michael R. Hayden and Donald W. Nicholson Nature Cell Biology4, 95–105
(February 2002); doi:10.1038/ncb735
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news and views Huntington's disease: Accomplices to neuronal death
Mark P. Mattson Nature 415, 377–379
(January 2002); doi:10.1038/415377a
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news and views Ignition of a cellular machine
Mara Kreishman-Deltrick and Michael K. Rosen Nature Cell Biology4, E31
(February 2002); doi:10.1038/ncb0202-e31
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news and views 'Rab'ing up endosomal membrane transport
Magda Deneka and Peter van der Sluijs Nature Cell Biology4, E33
(February 2002); doi:10.1038/ncb0202-e33
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article Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes
Stefano De Renzis, Birte Sönnichsen and Marino Zerial Nature Cell Biology4, 124–133
(February 2002); doi:10.1038/ncb744
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news and views Tumor viral escape from inhibited T cells
Raymond M. Welsh, Susan E. Stepp, Eva Szomolanyi-Tsuda and Craig D. Peacock Nature Immunology3, 112–114
(February 2002); doi:10.1038/ni0202-112
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article CD94-NKG2A receptors regulate antiviral CD8+ T cell responses
Janice M. Moser, James Gibbs, Peter E. Jensen and Aron E. Lukacher Nature Immunology3, 189–195
(February 2002); doi:10.1038/ni757
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news and views Effector BCRs: inside information on IgG
Tim Manser Nature Immunology3, 114–116
(February 2002); doi:10.1038/ni0202-114
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article Burst-enhancing role of the IgG membrane tail as a molecular determinant of memory
Stephen W. Martin and Christopher C. Goodnow Nature Immunology3, 182–188
(February 2002); doi:10.1038/ni752
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news and views The last molecular fortress in leukocyte trans-endothelial migration
Michel Aurrand-Lions, Caroline Johnson-Leger and Beat A. Imhof Nature Immunology3, 116–118
(February 2002); doi:10.1038/ni0202-116
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article CD99 plays a major role in the migration of monocytes through endothelial junctions
Alan R. Schenkel, Zahra Mamdouh, Xia Chen, Ronald M. Liebman and William A. Muller Nature Immunology3, 143–150
(February 2002); doi:10.1038/ni749
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article JAM-1 is a ligand of the b2 integrin LFA-1 involved in transendothelial migration of leukocytes
Georg Ostermann, Kim S. C. Weber, Alma Zernecke, Andreas Schröder and Christian Weber Nature Immunology3, 151–158
(February 2002); doi:10.1038/ni755
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news and views A GTPase gate for protein import into chloroplasts
Felix Kessler and Danny J. Schnell Nature Structural Biology 9, 81–83
(February 2002); doi:10.1038/nsb0202-81
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letter Crystal structure of pea Toc34, a novel GTPase of the chloroplast protein translocon
Yuh-Ju Sun, Farhad Forouhar, Hsou-min Li, Shuh-Long Tu, Yi-Hong Yeh, Sen Kao, Hui-Lin Shr, Chia-Cheng Chou, Chinpan Chen and Chwan-Deng Hsiao Nature Structural Biology 9, 95–100
(February 2002); doi:10.1038/nsb744
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article Akt inhibits Myt1 in the signalling pathway that leads to meiotic G2/M-phase transition
Eiichi Okumura, Takeshi Fukuhara, Hitoshi Yoshida, Shin-ichiro Hanada, Rie Kozutsumi, Masashi Mori, Kazunori Tachibana and Takeo Kishimoto Nature Cell Biology4, 111–116
(February 2002); doi:10.1038/ncb741
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brief communication A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence
Daniel S. Peeper, Avi Shvarts, Thijn Brummelkamp, Sirith Douma, Eugene Y. Koh, George Q. Daley and René Bernards Nature Cell Biology4, 148–153
(February 2002); doi:10.1038/ncb742
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brief communication Identification of Sef, a novel modulator of FGF signalling
Michael Tsang, Robert Friesel, Tetsuhiro Kudoh and Igor B. Dawid Nature Cell Biology4, 165–169
(February 2002); doi:10.1038/ncb749
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brief communication Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling
Maximilian Fürthauer, Wei Lin, Siew-Lan Ang, Bernard Thisse and Christine Thisse Nature Cell Biology4, 170–174
(February 2002); doi:10.1038/ncb750
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brief communication IAPs are essential for GDNF-mediated neuroprotective effects in injured motor neurons in vivo
D. Perrelet, A. Ferri, P. Liston, P. Muzzin, R.G. Korneluk and A. C. Kato Nature Cell Biology4, 175–179
(February 2002); doi:10.1038/ncb751
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review article Drosophila innate immunity: an evolutionary perspective
Jules A. Hoffmann and Jean-Marc Reichhart Nature Immunology3, 121–126
(February 2002); doi:10.1038/ni0202-121
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article Role of ICAM-3 in the initial interaction of T lymphocytes and APCs
María C. Montoya, David Sancho, Grégory Bonello, Yves Collette, Claire Langlet, Hai Tao He, Pedro Aparicio, Andrés Alcover, Daniel Olive and Francisco Sánchez-Madrid Nature Immunology3, 159–168
(February 2002); doi:10.1038/ni753
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article Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
Hiroaki Hemmi, Tsuneyasu Kaisho, Osamu Takeuchi, Shintaro Sato, Hideki Sanjo, Katsuaki Hoshino, Takao Horiuchi, Hideyuki Tomizawa, Kiyoshi Takeda and Shizuo Akira Nature Immunology3, 196–200
(February 2002); doi:10.1038/ni758
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letters to nature S-Cdk-dependent phosphorylation of Sld2 essential for chromosomal DNA replication in budding yeast
Hiroshi Masumoto, Sachiko Muramatsu, Yoichiro Kamimura and Hiroyuki Araki Nature415, 651–655
(February 2002); doi:10.1038/nature713
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letters to nature RanGAP mediates GTP hydrolysis without an arginine finger
Michael J. Seewald, Carolin Körner, Alfred Wittinghofer and Ingrid R. Vetter Nature 415, 662–666
(February 2002); doi:10.1038/415662a
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news and views New avenues for anti-inflammatory therapy
Charles R. Mackay Nature Medicine 8, 117–118
(February 2002); doi:10.1038/nm0202-117
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article CCL27-CCR10 interactions regulate T cell-mediated skin inflammation
Bernard Homey, Harri Alenius, Anja Müller, Hortensia Soto, Edward P. Bowman, Wei Yuan, Leslie McEvoy, Antti I. Lauerma, Till Assmann, Erich Bünemann, Maili Lehto, Henrik Wolff, David Yen, Heather Marxhausen, Wayne To, Jonathon Sedgwick, Thomas Ruzicka, Percy Lehmann and Albert Zlotnik Nature Medicine 8, 157–165
(February 2002); doi:10.1038/nm0202-157
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article Steps toward mapping the human vasculature by phage display
Wadih Arap, Mikhail G. Kolonin, Martin Trepel, Johanna Lahdenranta, Marina Cardó-Vila, Ricardo J. Giordano, Paul J. Mintz, Peter U. Ardelt, Virginia J. Yao, Claudia I. Vidal, Limor Chen, Anne Flamm, Heli Valtanen, Lisa M. Weavind, Marshall E. Hicks, Raphael E. Pollock, Gregory H. Botz, Corazon D. Bucana, Erkki Koivunen, Dolores Cahill, Patricia Troncoso, Keith A. Baggerly, Rebecca D. Pentz, Kim-Anh Do, Christopher J. Logothetis and Renata Pasqualini Nature Medicine 8, 121–127
(February 2002); doi:10.1038/nm0202-121
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letters to nature Vesicular restriction of synaptobrevin suggests a role for calcium in membrane fusion
Kuang Hu, Joe Carroll, Sergei Fedorovich, Colin Rickman, Andrei Sukhodub and Bazbek Davletov Nature 415, 646–650
(February 2002); doi:10.1038/415646a
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insight The pathogenic basis of malaria
Louis H. Miller, Dror I. Baruch, Kevin Marsh and Ogobara K. Doumbo Nature 415, 673–679
(February 2002); doi:10.1038/415673a
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letters to nature Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits
Jon E. Chatterton, Marc Awobuluyi, Louis S. Premkumar, Hiroto Takahashi, Maria Talantova, Yeonsook Shin, Jiankun Cui, Shichun Tu, Kevin A. Sevarino, Nobuki Nakanishi, Gang Tong, Stuart A. Lipton and Dongxian Zhang Nature415, 793–798
(February 2002); doi:10.1038/nature715
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letters to nature Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARa
H. Eric Xu, Thomas B. Stanley, Valerie G. Montana, Millard H. Lambert, Barry G. Shearer, Jeffery E. Cobb, David D. McKee, Cristin M. Galardi, Kelli D. Plunket, Robert T. Nolte, Derek J. Parks, John T. Moore, Steven A. Kliewer, Timothy M. Willson and Julie B. Stimmel Nature 415, 813–817
(February 2002); doi:10.1038/415813a
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news and views Genome sequencing: Brouhaha over the other yeast
Jonathan A. Eisen Nature415, 845–848
(February 2002); doi:10.1038/nature725
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article The genome sequence of Schizosaccharomycespombe
V. Wood, R. Gwilliam, M. A. Rajandream, M. Lyne, R. Lyne, A. Stewart, J. Sgouros, N. Peat, J. Hayles, S. Baker, D. Basham, S. Bowman, K. Brooks, D. Brown, S. Brown, T. Chillingworth, C. Churcher, M. Collins, R. Connor, A. Cronin, P. Davis, T. Feltwell, A. Fraser, S. Gentles, A. Goble, N. Hamlin, D. Harris, J. Hidalgo, G. Hodgson, S. Holroyd, T. Hornsby, S. Howarth, E. J. Huckle, S. Hunt, K. Jagels, K. James, L. Jones, M. Jones, S. Leather, S. McDonald, J. McLean, P. Mooney, S. Moule, K. Mungall, L. Murphy, D. Niblett, C. Odell, K. Oliver, S. O'Neil, D. Pearson, M. A. Quail, E. Rabbinowitsch, K. Rutherford, S. Rutter, D. Saunders, K. Seeger, S. Sharp, J. Skelton, M. Simmonds, R. Squares, S. Squares, K. Stevens, K. Taylor, R. G. Taylor, A. Tivey, S. Walsh, T. Warren, S. Whitehead, J. Woodward, G. Volckaert, R. Aert, J. Robben, B. Grymonprez, I. Weltjens, E. Vanstreels, M. Rieger, M. Schäfer, S. Müller-Auer, C. Gabel, M. Fuchs, C. Fritzc, E. Holzer, D. Moestl, H. Hilbert, K. Borzym, I. Langer, A. Beck, H. Lehrach, R. Reinhardt, T. M. Pohl, P. Eger, W. Zimmermann, H. Wedler, R. Wambutt, B. Purnelle, A. Goffeau, E. Cadieu, S. Dréano, S. Gloux, V. Lelaure, S. Mottier, F. Galibert, S. J. Aves, Z. Xiang, C. Hunt, K. Moore, S. M. Hurst, M. Lucas, M. Rochet, C. Gaillardin, V. A. Tallada, A. Garzon, G. Thode, R. R. Daga, L. Cruzado, J. Jimenez, M. Sánchez, F. del Rey, J. Benito, A. Domínguez, J. L. Revuelta, S. Moreno, J. Armstrong, S. L. Forsburg, L. Cerrutti, T. Lowe, W. R. McCombie, I. Paulsen, J. Potashkin, G. V. Shpakovski, D. Ussery, B. G. Barrell and P. Nurse Nature415, 871–880
(February 2002); doi:10.1038/nature724
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letters to nature BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes
Philippe Bouillet, Jared F. Purton, Dale I. Godfrey, Li-Chen Zhang, Leigh Coultas, Hamsa Puthalakath, Marc Pellegrini, Suzanne Cory, Jerry M. Adams and Andreas Strasser Nature 415, 922–926
(February 2002); doi:10.1038/415922a
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letters to nature Structural basis for acidic-cluster-dileucine sorting-signal recognition by VHS domains
Saurav Misra, Rosa Puertollano, Yukio Kato, Juan S. Bonifacino and James H. Hurley Nature 415, 933–937
(February 2002); doi:10.1038/415933a
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letters to nature Structural basis for recognition of acidic-cluster dileucine sequence by GGA1
Tomoo Shiba, Hiroyuki Takatsu, Terukazu Nogi, Naohiro Matsugaki, Masato Kawasaki, Noriyuki Igarashi, Mamoru Suzuki, Ryuichi Kato, Thomas Earnest, Kazuhisa Nakayama and Soichi Wakatsuki Nature 415, 937–941
(February 2002); doi:10.1038/415937a
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article MAP kinase signalling cascade in Arabidopsis innate immunity
Tsuneaki Asai, Guillaume Tena, Joulia Plotnikova, Matthew R. Willmann, Wan-Ling Chiu, Lourdes Gomez-Gomez, Thomas Boller, Frederick M. Ausubel and Jen Sheen Nature 415, 977–983
(February 2002); doi:10.1038/415977a
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letters to nature Characterization of a common precursor population for dendritic cells
Gloria Martínez del Hoyo, Pilar Martín, Héctor Hernández Vargas, Sara Ruiz, Cristina Fernández Arias and Carlos Ardavín Nature 415, 1043–1047
(February 2002); doi:10.1038/4151043a
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letters to nature A blue-light-activated adenylyl cyclase mediates photoavoidance in Euglena gracilis
Mineo Iseki, Shigeru Matsunaga, Akio Murakami, Kaoru Ohno, Kiyoshi Shiga, Kazuichi Yoshida, Michizo Sugai, Tetsuo Takahashi, Terumitsu Hori and Masakatsu Watanabe Nature 415, 1047–1051
(February 2002); doi:10.1038/4151047a
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letter The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin
Ikuko Hayashi, Kristiina Vuori and Robert C. Liddington Nature Structural Biology 9, 101–106
(February 2002); doi:10.1038/nsb755
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letter Loss of a metal-binding site in gelsolin leads to familial amyloidosis-Finnish type
Steven L. Kazmirski, Rivka L. Isaacson, Chahm An, Ashley Buckle, Christopher M. Johnson, Valerie Daggett and Alan R. Fersht Nature Structural Biology 9, 112–116
(February 2002); doi:10.1038/nsb745
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letter Structure of the Bcr-Abl oncoprotein oligomerization domain
Xun Zhao, Saghi Ghaffari, Harvey Lodish, Vladimir N. Malashkevich and Peter S. Kim Nature Structural Biology 9, 117–120
(February 2002); doi:10.1038/nsb747
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article SNARE assembly and disassembly exhibit a pronounced hysteresis
Dirk Fasshauer, Wolfram Antonin, Vinod Subramaniam and Reinhard Jahn Nature Structural Biology 9, 144–151
(February 2002); doi:10.1038/nsb750
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article Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance
Jun Shimizu, Sayuri Yamazaki, Takeshi Takahashi, Yasumasa Ishida and Shimon Sakaguchi Nature Immunology3, 135–142
(February 2002); doi:10.1038/ni759
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