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The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.
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commentary
Selector and signalling molecules cooperate in organ patterning
Jennifer Curtiss, Georg Halder and Marek Mlodzik
Nature Cell Biology 4, E48
(March 2002); doi:10.1038/ncb0302-e48
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review article
PHOSPHOTYROSINE-BINDING DOMAINS IN SIGNAL TRANSDUCTION
Michael B. Yaffe
Nature Reviews Molecular Cell Biology 3, 177–186
(March 2002); doi:10.1038/nrm759
| Abstract | Full Text (HTML/PDF) |
perspectives
TIMELINE: Matrix metalloproteinases: a tail of a frog that became a prince
Constance E. Brinckerhoff and Lynn M. Matrisian
Nature Reviews Molecular Cell Biology 3, 207–214
(March 2002); doi:10.1038/nrm763
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review article
MECHANISMS OF AGEING: PUBLIC OR PRIVATE?
Linda Partridge and David Gems
Nature Reviews Genetics 3, 165–175
(March 2002); doi:10.1038/nrg753
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review article
GETTING UNDER THE SKIN OF EPIDERMAL MORPHOGENESIS
Elaine Fuchs and Srikala Raghavan
Nature Reviews Genetics 3, 199–209
(March 2002); doi:10.1038/nrg758
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review article
REGULATORS OF G-PROTEIN SIGNALLING AS NEW CENTRAL NERVOUS SYSTEM DRUG TARGETS
Richard R. Neubig and David P. Siderovski
Nature Reviews Drug Discovery 1, 187–197
(March 2002); doi:10.1038/nrd747
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review article
ALLOSTERIC BINDING SITES ON CELL-SURFACE RECEPTORS: NOVEL TARGETS FOR DRUG DISCOVERY
Arthur Christopoulos
Nature Reviews Drug Discovery 1, 198–210
(March 2002); doi:10.1038/nrd746
| Abstract | Full Text (HTML/PDF) |
perspectives
INNOVATION: Indirect monitoring of lung inflammation
Paolo Montuschi
Nature Reviews Drug Discovery 1, 238–242
(March 2002); doi:10.1038/nrd751
| Abstract | Full Text (HTML/PDF) |
review article
THE MOLECULAR BASIS OF CaMKII FUNCTION IN SYNAPTIC AND BEHAVIOURAL MEMORY
John Lisman, Howard Schulman and Hollis Cline
Nature Reviews Neuroscience 3, 175–190
(March 2002); doi:10.1038/nrn753
| Abstract | Full Text (HTML/PDF) |
review article
NEW FUNCTIONS FOR THE MATRIX METALLOPROTEINASES IN CANCER PROGRESSION
Mikala Egeblad and Zena Werb
Nature Reviews Cancer 2, 163–176
(March 2002); doi:10.1038/nrc745
| Abstract | Full Text (HTML/PDF) |
review article
CHEMOKINES: AGENTS FOR THE IMMUNOTHERAPY OF CANCER?
Bernhard Homey, Anja Müller and Albert Zlotnik
Nature Reviews Immunology 2, 175–184
(March 2002); doi:10.1038/nri748
| Abstract | Full Text (HTML/PDF) |
review article
AUTOIMMUNE THYROID DISEASE: NEW MODELS OF CELL DEATH IN AUTOIMMUNITY
Giorgio Stassi and Ruggero De Maria
Nature Reviews Immunology 2, 195–204
(March 2002); doi:10.1038/nri750
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review article
INNATE IMMUNITY: THE MISSING LINK IN NEUROPROTECTION AND NEURODEGENERATION?
Minh Dang Nguyen, Jean-Pierre Julien and Serge Rivest
Nature Reviews Neuroscience 3, 216–227
(March 2002); doi:10.1038/nrn752
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article
SMIF, a Smad4-interacting protein that functions as a co-activator in TGFb signalling
Ren-Yuan Bai, Christina Koester, Tao Ouyang, Stephan A. Hahn, Matthias Hammerschmidt, Christian Peschel and Justus Duyster
Nature Cell Biology 4, 181–190
(March 2002); doi:10.1038/ncb753
| Abstract | Full Text (HTML/PDF) |
article
Polycystin-2 is an intracellular calcium release channel
Peter Koulen, Yiqiang Cai, Lin Geng, Yoshiko Maeda, Sayoko Nishimura, Ralph Witzgall, Barbara E. Ehrlich and Stefan Somlo
Nature Cell Biology 4, 191–197
(March 2002); doi:10.1038/ncb754
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article
A Drosophila APC tumour suppressor homologue functions in cellular adhesion
Fumihiko Hamada and Mariann Bienz
Nature Cell Biology 4, 208–213
(March 2002); doi:10.1038/ncb755
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article
Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex
Yasuyuki Fujita, Gerd Krause, Martin Scheffner, Dietmar Zechner, Hugo E. Molina Leddy, Jürgen Behrens and Thomas Sommer and Walter Birchmeier
Nature Cell Biology 4, 222–231
(March 2002); doi:10.1038/ncb758
| Abstract | Full Text (HTML/PDF) |
article
Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDI
Miguel Angel Del Pozo, William B. Kiosses, Nazilla B. Alderson, Nahum Meller, Klaus M. Hahn and Martin Alexander Schwartz
Nature Cell Biology 4, 232–239
(March 2002); doi:10.1038/ncb759
| Abstract | Full Text (HTML/PDF) |
brief communication
dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1
Thomas Radimerski, Jacques Montagne, Felix Rintelen, Hugo Stocker, Jeroen van der Kaay, C. Peter Downes, Ernst Hafen and George Thomas
Nature Cell Biology 4, 251–255
(March 2002); doi:10.1038/ncb763
| First Paragraph | Full Text (HTML/PDF) |
article
Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice
Tzong-Shyuan Lee and Lee-Young Chau
Nature Medicine 8, 240–246
(March 2002); doi:10.1038/nm0302-240
| Abstract | Full Text (HTML/PDF) |
article
CD40L stabilizes arterial thrombi by a b3 integrin-dependent mechanism
Patrick André, K.S. Srinivasa Prasad, Cécile V. Denis, Ming He, Jessie M. Papalia, Richard O. Hynes, David R. Phillips and Denisa D. Wagner
Nature Medicine 8, 247–252
(March 2002); doi:10.1038/nm0302-247
| Abstract | Full Text (HTML/PDF) |
article
Tumor-cell resistance to death receptor-induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax
Heidi LeBlanc, David Lawrence, Eugene Varfolomeev, Klara Totpal, John Morlan, Peter Schow, Sharon Fong, Ralph Schwall, Dominick Sinicropi and Avi Ashkenazi
Nature Medicine 8, 274–281
(March 2002); doi:10.1038/nm0302-274
| Abstract | Full Text (HTML/PDF) |
news and views
Apoptosis and cancer: When BAX is TRAILing away
Wilfried Roth and John C. Reed
Nature Medicine 8, 216–218
(March 2002); doi:10.1038/nm0302-216
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article
Prostaglandin E2 transactivates EGF receptor: A novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy
Rama Pai, Brian Soreghan, Imre L. Szabo, Meredith Pavelka, Dolgor Baatar and Andrzej S. Tarnawski
Nature Medicine 8, 289–293
(March 2002); doi:10.1038/nm0302-289
| Abstract | Full Text (HTML/PDF) |
article
CEACAM1 regulates insulin clearance in liver
Matthew N. Poy, Yan Yang, Khadijeh Rezaei, Mats A. Fernström, Abraham D. Lee, Yoshiaki Kido, Sandra K. Erickson and Sonia M. Najjar
Nature Genetics 30, 270–276
(March 2002); doi:10.1038/ng840
| Abstract | Full Text (HTML/PDF) |
letter
BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage
Ronit I. Yarden, Sherly Pardo-Reoyo, Magda Sgagias, Kenneth H. Cowan and Lawrence C. Brody
Nature Genetics 30, 285–289
(March 2002); doi:10.1038/ng837
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letter
The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways
Jacob Falck, John H.J. Petrini, Bret R. Williams, Jiri Lukas and Jiri Bartek
Nature Genetics 30, 290–294
(March 2002); doi:10.1038/ng845
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letter
A mutant PTH/PTHrP type I receptor in enchondromatosis
Sevan Hopyan, Nalan Gokgoz, Raymond Poon, Robert C. Gensure, Chunying Yu, William G. Cole, Robert S. Bell, Harald Jüppner, Irene L. Andrulis, Jay S. Wunder and Benjamin A. Alman
Nature Genetics 30, 306–310
(March 2002); doi:10.1038/ng844
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letter
Structural basis for CDK6 activation by a virus-encoded cyclin
Ursula Schulze-Gahmen and Sung-Hou Kim
Nature Structural Biology 9, 177–181
(March 2002); doi:10.1038/nsb756
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letter
Crystal structure of the human TbR2 ectodomain-TGF-b3 complex
P. John Hart, Shashank Deep, Alexander B. Taylor, Zhanyong Shu, Cynthia S. Hinck and Andrew P. Hinck
Nature Structural Biology 9, 203–208
(March 2002); doi:10.1038/nsb766
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research article
Tumor antigen-specific induction of transcriptionally targeted retroviral vectors from chimeric immune receptor-modified T cells
John Chester, Anja Ruchatz, Michael Gough, Marka Crittenden, Heung Chong, François Loïc-Cosset, Rosa Maria Diaz, Kevin Harrington, Luis Alvarez-Vallina and Richard Vile
Nature Biotechnology 20, 256–263
(March 2002); doi:10.1038/nbt0302-256
| Abstract | Full Text (HTML/PDF) |
research article
Fluorescent indicators for imaging protein phosphorylation in single living cells
Moritoshi Sato, Takeaki Ozawa, Kouichi Inukai, Tomoichiro Asano and Yoshio Umezawa
Nature Biotechnology 20, 287–294
(March 2002); doi:10.1038/nbt0302-287
| Abstract | Full Text (HTML/PDF) |
letters to nature
TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2
Xiaoming Li, Yili Yang and Jonathan D. Ashwell
Nature 416, 345–347
(March 2002); doi:10.1038/416345a
| First Paragraph | Full Text (HTML/PDF) |
news and views
The ins and outs of polycystin-2 as a calcium release channel
Michael D. Cahalan
Nature Cell Biology 4, E56
(March 2002); doi:10.1038/ncb0302-e56
| Full Text (HTML/PDF) |
news and views
Neurobiology: A cool ion channel
Charles S. Zuker
Nature 416, 27–28
(March 2002); doi:10.1038/416027a
| Full Text (HTML/PDF) |
article
Identification of a cold receptor reveals a general role for TRP channels in thermosensation
David D. McKemy, Werner M. Neuhausser and David Julius
Nature 416, 52–59
(March 2002); doi:10.1038/nature719
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letters to nature
Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position
Karin Reif, Eric H. Ekland, Lars Ohl, Hideki Nakano, Martin Lipp, Reinhold Förster and Jason G. Cyster
Nature 416, 94–99
(March 2002); doi:10.1038/416094a
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news and views
Neurobiology: The bitter-sweet taste of amino acids
Lesley Anson
Nature 416, 136
(February 2002); doi:10.1038/416136b
| Full Text (HTML/PDF) |
news and views
Cell biology: A new view of photoreceptors
Franck Pichaud and Claude Desplan
Nature 416, 139–140
(February 2002); doi:10.1038/416139a
| Full Text (HTML/PDF) |
article
Crumbs, the Drosophila homologue of human CRB1/RP12, is essential for photoreceptor morphogenesis
Milena Pellikka, Guy Tanentzapf, Madalena Pinto, Christian Smith, C. Jane McGlade, Donald F. Ready and Ulrich Tepass
Nature 416, 143–149
(March 2002); doi:10.1038/nature721
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letters to nature
Drosophila Crumbs is a positional cue in photoreceptor adherens junctions and rhabdomeres
Shayan Izaddoost, Sand-Chul Nam, Manzoor A. Bhat, Hugo J. Bellen & Kwang-Wook Choi
Nature 416, 178–182
(March 2002); doi:10.1038/nature720
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letters to nature
Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors
Philippe Soubeyran, Katarzyna Kowanetz, Iwona Szymkiewicz, Wallace Y. Langdon and Ivan Dikic
Nature 416, 183–187
(March 2002); doi:10.1038/416183a
| First Paragraph | Full Text (HTML/PDF) |
news and views
Signal transduction: Molecular ticket to enter cells
Shlomo Oved and Yosef Yarden
Nature 416, 133–136
(February 2002); doi:10.1038/416133a
| Full Text (HTML/PDF) |
letters to nature
The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met
Annalisa Petrelli, Giorgio F. Gilestro, Stefania Lanzardo, Paolo M. Comoglio, Nicola Migone and Silvia Giordano
Nature 416, 187–190
(March 2002); doi:10.1038/416187a
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letters to nature
Involvement of receptor-interacting protein 2 in innate and adaptive immune responses
Arnold I. Chin, Paul W. Dempsey, Kevin Bruhn, Jeff F. Miller, Yang Xu and Genhong Cheng
Nature 416, 190–194
(March 2002); doi:10.1038/416190a
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letters to nature
RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems
Koichi Kobayashi, Naohiro Inohara, Lorraine D. Hernandez, Jorge E. Galán, Gabriel Núñez, Charles A. Janeway, Ruslan Medzhitov and Richard A. Flavell
Nature 416, 194–199
(March 2002); doi:10.1038/416194a
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letters to nature
An amino-acid taste receptor
Greg Nelson, Jayaram Chandrashekar, Mark A. Hoon, Luxin Feng, Grace Zhao, Nicholas J. P. Ryba & Charles S. Zuker
Nature 416, 199–202
(March 2002); doi:10.1038/nature726
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news and views
Cell biology: The ubiquitin connection
Howard Riezman
Nature 416, 381–383
(March 2002); doi:10.1038/416381a
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letters to nature
A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins
Simona Polo, Sara Sigismund, Mario Faretta, Monica Guidi, Maria Rosaria Capua, Giovanna Bossi, Hong Chen, Pietro De Camilli and Pier Paolo Di Fiore
Nature 416, 451–455
(March 2002); doi:10.1038/416451a
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letters to nature
Rac function and regulation during Drosophila development
Satoko Hakeda-Suzuki, Julian Ng, Julia Tzu, Georg Dietzl, Yan Sun, Matthew Harms, Tim Nardine, Liqun Luo and Barry J. Dickson
Nature 416, 438–442
(March 2002); doi:10.1038/416438a
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letters to nature
Rac GTPases control axon growth, guidance and branching
Julian Ng, Timothy Nardine, Matthew Harms, Julia Tzu, Ann Goldstein, Yan Sun, Georg Dietzl, Barry J. Dickson and Liqun Luo
Nature 416, 442–447
(March 2002); doi:10.1038/416442a
| First Paragraph | Full Text (HTML/PDF) |
news and views
Molecular physiology: Protecting the heart
Mark T. Nelson and Gerald M. Herrera
Nature 416, 273–274
(March 2002); doi:10.1038/416273a
| Full Text (HTML/PDF) |
letters to nature
Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy
Hong-Bo Xin, Takaaki Senbonmatsu, Dong-Sheng Cheng, Yong-Xiao Wang, Julio A. Copello, Guang-Ju Ji, Mei Lin Collier, Ke-Yu Deng, Loice H. Jeyakumar, Mark A. Magnuson, Tadashi Inagami, Michael I. Kotlikoff and Sidney Fleischer
Nature 416, 334–338
(March 2002); doi:10.1038/416334a
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letters to nature
Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms
Lili A. Barouch, Robert W. Harrison, Michel W. Skaf, Gisele O. Rosas, Thomas P. Cappola, Zoulficar A. Kobeissi, Ion A. Hobai, Christopher A. Lemmon, Arthur L. Burnett, Brian O'Rourke, E. Rene Rodriguez, Paul L. Huang, João A. C. Lima, Dan E. Berkowitz and Joshua M. Hare
Nature 416, 337–339
(March 2002); doi:10.1038/416005a
| First Paragraph | Full Text (HTML/PDF) |
letters to nature
TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2
Xiaoming Li, Yili Yang and Jonathan D. Ashwell
Nature 416, 345–347
(March 2002); doi:10.1038/416345a
| First Paragraph | Full Text (HTML/PDF) |
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