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The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.
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article
Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
Elizabeth A. Leadbetter, Ian R. Rifkin, Andreas M. Hohlbaum, Britte C. Beaudette, Mark J. Shlomchik and Ann Marshak-Rothstein
Nature 416, 603–607
(April 2002); doi:10.1038/416603a
| Summary | Full Text (HTML/PDF) |
letters to nature
The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein
Marie Gottar, Vanessa Gobert, Tatiana Michel, Marcia Belvin, Geoffrey Duyk, Jules A. Hoffmann, Dominique Ferrandon and Julien Royet
Nature 416, 640–644
(April 2002); doi:10.1038/nature734
| First Paragraph | Full Text (HTML/PDF) |
letters to nature
Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli
Mika Rämet, Pascal Manfruelli, Alan Pearson, Bernard Mathey-Prevot and R. Alan B. Ezekowitz
Nature 416, 644–648
(April 2002); doi:10.1038/nature735
| First Paragraph | Full Text (HTML/PDF) |
news and views
Immunology: DNA drives autoimmunity
Carola G. Vinuesa and Christopher C. Goodnow
Nature 416, 595–598
(April 2002); doi:10.1038/416595a
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article
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex
Ning Zheng, Brenda A. Schulman, Langzhou Song, Julie J. Miller, Philip D. Jeffrey, Ping Wang, Claire Chu, Deanna M. Koepp, Stephen J. Elledge, Michele Pagano, Ronald C. Conaway, Joan W. Conaway, J. Wade Harper and Nikola P. Pavletich
Nature 416, 703–709
(April 2002); doi:10.1038/416703a
| Summary | Full Text (HTML/PDF) |
letters to nature
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization
Muyang Li, Delin Chen, Ariel Shiloh, Jianyuan Luo, Anatoly Y. Nikolaev, Jun Qin and Wei Gu
Nature 416, 648–653
(April 2002); doi:10.1038/nature737
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letters to nature
Dissecting glucose signalling with diversity-oriented synthesis and small-molecule microarrays
Finny G. Kuruvilla, Alykhan F. Shamji, Scott M. Sternson, Paul J. Hergenrother and Stuart L. Schreiber
Nature 416, 653–657
(April 2002); doi:10.1038/416653a
| First Paragraph | Full Text (HTML/PDF) |
letters to nature
Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4
Nobutaka Suzuki, Shinobu Suzuki, Gordon S. Duncan, Douglas G. Millar, Teiji Wada, Christine Mirtsos, Hidetoshi Takada, Andrew Wakeham, Annick Itie, Shyun Li, Josef M. Penninger, Holger Wesche, Pamela S. Ohashi, Tak W. Mak and Wen-Chen Yeh
Nature 416, 750–756
(April 2002); doi:10.1038/nature736
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letters to nature
Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus
Jianhang Jia, Kazuhito Amanai, Gelin Wang, Jiong Tang, Bing Wang and Jin Jiang
Nature 416, 548–552
(April 2002); doi:10.1038/nature733
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letters to nature
Cells compete for Decapentaplegic survival factor to prevent apoptosis in Drosophila wing development
Eduardo Moreno, Konrad Basler and Ginés Morata
Nature 416, 755–759
(April 2002); doi:10.1038/416755a
| First Paragraph | Full Text (HTML/PDF) |
letters to nature
SWAP-70 is a guanine-nucleotide-exchange factor that mediates signalling of membrane ruffling
Masahiro Shinohara, Yoh Terada, Akihiro Iwamatsu, Azusa Shinohara, Naoki Mochizuki, Maiko Higuchi, Yukiko Gotoh, Sayoko Ihara, Satoshi Nagata, Hiroshi Itoh, Yasuhisa Fukui and Rolf Jessberger
Nature 416, 759–763
(April 2002); doi:10.1038/416759a
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letters to nature
A proteasomal ATPase subunit recognizes the polyubiquitin degradation signal
Y. Amy Lam, T. Glen Lawson, Murugesan Velayutham, Jay L. Zweier and Cecile M. Pickart
Nature 416, 763–767
(April 2002); doi:10.1038/416763a
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letters to nature
p63 and p73 are required for p53-dependent apoptosis in response to DNA damage
Elsa R. Flores, Kenneth Y. Tsai, Denise Crowley, Shomit Sengupta, Annie Yang, Frank McKeon and Tyler Jacks
Nature 416, 560–564
(April 2002); doi:10.1038/416560a
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letters to nature
RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-b
Hiroshi Takayanagi, Sunhwa Kim, Koichi Matsuo, Hiroshi Suzuki, Tomohiko Suzuki, Kojiro Sato, Taeko Yokochi, Hiromi Oda, Kozo Nakamura, Nobutaka Ida, Erwin F. Wagner and Tadatsugu Taniguchi
Nature 416, 744–749
(April 2002); doi:10.1038/416744a
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news and views
Medicine: Interfering with bone remodelling
Tamara Alliston and Rik Derynck
Nature 416, 686–687
(April 2002); doi:10.1038/416686a
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letters to nature
Emi1 is required for cytostatic factor arrest in vertebrate eggs
Julie D. R. Reimann and Peter K. Jackson
Nature 416, 850–854
(April 2002); doi:10.1038/416850a
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news and views
Developmental biology: An arresting activity
Nicholas S. Duesbery and George F. Vande Woude
Nature 416, 804–805
(April 2002); doi:10.1038/416804a
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letters to nature
Protein kinase Cd controls self-antigen-induced B-cell tolerance
Ingrid Mecklenbräuker, Kaoru Saijo, Nai-Ying Zheng, Michael Leitges and Alexander Tarakhovsky
Nature 416, 860–865
(April 2002); doi:10.1038/416860a
| First Paragraph | Full Text (HTML/PDF) |
letters to nature
Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cd
Akitomo Miyamoto, Keiko Nakayama, Hiroyuki Imaki, Sachiko Hirose, Yi Jiang, Masaaki Abe, Tadasuke Tsukiyama, Hiroyasu Nagahama, Shigeo Ohno, Shigetsugu Hatakeyama and Keiichi I. Nakayama
Nature 416, 865–869
(April 2002); doi:10.1038/416865a
| First Paragraph | Full Text (HTML/PDF) |
letters to nature
AP-1 functions upstream of CREB to control synaptic plasticity in Drosophila
Subhabrata Sanyal, David J. Sandstrom, Charles A. Hoeffer and Mani Ramaswami
Nature 416, 870–874
(April 2002); doi:10.1038/416870a
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letters to nature
Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4
Thomas Boettger, Christian A. Hübner, Hannes Maier, Marco B. Rust, Franz X. Beck and Thomas J. Jentsch
Nature 416, 874–878
(April 2002); doi:10.1038/416874a
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letters to nature
Structural determinants for GoLoco-induced inhibition of nucleotide release by Ga subunits
Randall J. Kimple, Michelle E. Kimple, Laurie Betts, John Sondek and David P. Siderovski
Nature 416, 878–881
(April 2002); doi:10.1038/416878a
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news and views
Developmental biology: The plastic face
Massimo Pasqualetti and Filippo M. Rijli
Nature 416, 493–494
(April 2002); doi:10.1038/416493a
| Full Text (HTML/PDF) |
article
Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton
Mira Krendel, Frank T. Zenke and Gary M. Bokoch
Nature Cell Biology 4, 294–301
(April 2002); doi:10.1038/ncb773
| Abstract | Full Text (HTML/PDF) |
article
Identification of an organelle receptor for myosin-Va
Xufeng S. Wu, Kang Rao, Hong Zhang, Fei Wang, James R. Sellers, Lydia E. Matesic, Neal G. Copeland, Nancy A. Jenkins and John A. Hammer III
Nature Cell Biology 4, 271–278
(April 2002); doi:10.1038/ncb760
| Abstract | Full Text (HTML/PDF) |
news and views
How Rab proteins link motors to membranes
Bruno Goud
Nature Cell Biology 4, E77
(April 2002); doi:10.1038/ncb0402-e77
| Full Text (HTML/PDF) |
article
Quantal release of free radicals during exocytosis of phagosomes
Anke Di, Boris Krupa, Vytas P. Bindokas, Yimei Chen, Mary E. Brown, H. Clive Palfrey, Anjaparavanda P. Naren, Kevin L. Kirk and Deborah J. Nelson
Nature Cell Biology 4, 279–285
(April 2002); doi:10.1038/ncb771
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article
Dissecting the link between stress fibres and focal adhesions by CALI with EGFP fusion proteins
Zenon Rajfur, Partha Roy, Carol Otey, Lewis Romer and Ken Jacobson
Nature Cell Biology 4, 286–293
(April 2002); doi:10.1038/ncb772
| Abstract | Full Text (HTML/PDF) |
brief communication
Myosin IXb is a single-headed minus-end-directed processive motor
Akira Inoue, Junya Saito, Reiko Ikebe and Mitsuo Ikebe
Nature Cell Biology 4, 302–306
(April 2002); doi:10.1038/ncb774
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brief communication
Calcium-dependent membrane association sensitizes soluble guanylyl cyclase to nitric oxide
Ulrike Zabel, Christoph Kleinschnitz, Phil Oh, Pavel Nedvetsky, Albert Smolenski, Helmut Müller, Petra Kronich, Peter Kugler, Ulrich Walter, Jan E. Schnitzer and Harald H. H. W. Schmidt
Nature Cell Biology 4, 307–311
(April 2002); doi:10.1038/ncb775
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brief communication
The myosin converter domain modulates muscle performance
Douglas M. Swank, Aileen F. Knowles, Jennifer A. Suggs, Floyd Sarsoza, Annie Lee, David W. Maughan and Sanford I. Bernstein
Nature Cell Biology 4, 312–317
(April 2002); doi:10.1038/ncb776
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brief communication
Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation
Niels Mailand, Claudia Lukas, Brett K. Kaiser, Peter K. Jackson, Jiri Bartek and Jiri Lukas
Nature Cell Biology 4, 318–322
(April 2002); doi:10.1038/ncb777
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brief communication
Identification of a link between the tumour suppressor APC and the kinesin superfamily
Takeshi Jimbo, Yoshihiro Kawasaki, Ryo Koyama, Rina Sato, Shinji Takada, Keiko Haraguchi and Tetsu Akiyama
Nature Cell Biology 4, 323–327
(April 2002); doi:10.1038/ncb779
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news and views
Herpesvirus hijacks an integrin
Glen R. Nemerow and David A. Cheresh
Nature Cell Biology 4, E69
(April 2002); doi:10.1038/ncb0402-e69
| Full Text (HTML/PDF) |
news and views
Neighbourhood Watch for the cytoskeleton
Alison Schuldt
Nature Cell Biology 4, E71
(April 2002); doi:10.1038/ncb0402-e71
| Full Text (HTML/PDF) |
news and views
E-cadherin and Hakai: signalling, remodeling or destruction?
Salvatore Pece and J. Silvio Gutkind
Nature Cell Biology 4, E72
(April 2002); doi:10.1038/ncb0402-e72
| Full Text (HTML/PDF) |
news and views
Ready and Abl
Sarah Greaves
Nature Cell Biology 4, E74
(April 2002); doi:10.1038/ncb0402-e74
| Full Text (HTML/PDF) |
news and views
Integrin regulation of growth factor receptors
Kenneth M. Yamada and Sharona Even-Ram
Nature Cell Biology 4, E75
(April 2002); doi:10.1038/ncb0402-e75
| Full Text (HTML/PDF) |
news and views
A double-edged sword
Valerie Ferrier
Nature Cell Biology 4, E79
(April 2002); doi:10.1038/ncb0402-e79
| Full Text (HTML/PDF) |
review article
Adhesion assembly, disassembly and turnover in migrating cells - over and over and over again
Donna J. Webb, J. Thomas Parsons and Alan F. Horwitz
Nature Cell Biology 4, E97
(April 2002); doi:10.1038/ncb0402-e97
| Abstract | Full Text (HTML/PDF) |
review article
Intercellular adhesion, signalling and the cytoskeleton
Colin Jamora and Elaine Fuchs
Nature Cell Biology 4, E101
(April 2002); doi:10.1038/ncb0402-e101
| Abstract | Full Text (HTML/PDF) |
technology review
Microscope-based techniques to study cell adhesion and migration
Partha Roy, Zenon Rajfur, Pawel Pomorski and Ken Jacobson
Nature Cell Biology 4, E91
(April 2002); doi:10.1038/ncb0402-e91
| Abstract | Full Text (HTML/PDF) |
hypothesis
Sensing the environment: a historical perspective on integrin signal transduction
Cindy K. Miranti and Joan S. Brugge
Nature Cell Biology 4, E83
(April 2002); doi:10.1038/ncb0402-e83
| Abstract | Full Text (HTML/PDF) |
commentary
Networks and crosstalk: integrin signalling spreads
Martin A. Schwartz and Mark H. Ginsberg
Nature Cell Biology 4, E65
(April 2002); doi:10.1038/ncb0402-e65
| Full Text (HTML/PDF) |
review article
V-SRC'S HOLD OVER ACTIN AND CELL ADHESIONS
Margaret C. Frame, Valerie J. Fincham, Neil O. Carragher and John A. Wyke
Nature Reviews Molecular Cell Biology 3, 233–245
(April 2002); doi:10.1038/nrm779
| Abstract | Full Text (HTML/PDF) |
review article
REGULATED TRANSPORT OF THE GLUCOSE TRANSPORTER GLUT4
Nia J. Bryant, Roland Govers and David E. James
Nature Reviews Molecular Cell Biology 3, 267–277
(April 2002); doi:10.1038/nrm782
| Abstract | Full Text (HTML/PDF) |
review article
CLOSING IN ON THE BIOLOGICAL FUNCTIONS OF FPS/FES AND FER
Peter Greer
Nature Reviews Molecular Cell Biology 3, 278–289
(April 2002); doi:10.1038/nrm783
| Abstract | Full Text (HTML/PDF) |
article
Decreased allergic lung inflammatory cell egression and increased susceptibility to asphyxiation in MMP2-deficiency
David B. Corry, Kirtee Rishi, John Kanellis, Attila Kiss, Li-zhen Song, Jie Xu, Lili Feng, Zena Werb and Farrah Kheradmand
Nature Immunology 3, 347–353
(April 2002); doi:10.1038/ni773
| Abstract | Full Text (HTML/PDF) |
news and views
Killed by leukocytes that don't know when to leave
Dean Sheppard
Nature Immunology 3, 337–338
(April 2002); doi:10.1038/ni0402-337
| Full Text (HTML/PDF) |
article
Target cell defense prevents the development of diabetes after viral infection
Malin Flodström, Amy Maday, Deepika Balakrishna, Mary Malo Cleary, Akihiko Yoshimura and Nora Sarvetnick
Nature Immunology 3, 373–382
(April 2002); doi:10.1038/ni771
| Abstract | Full Text (HTML/PDF) |
news and views
Type 1 diabetes: virus infection or autoimmune disease?
DeLisa Fairweather and Noel R. Rose
Nature Immunology 3, 338–340
(April 2002); doi:10.1038/ni0402-338
| Full Text (HTML/PDF) |
article
How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease
Isao Matsumoto, Mariana Maccioni, David M. Lee, Madelon Maurice, Barry Simmons, Michael Brenner, Diane Mathis and Christophe Benoist
Nature Immunology 3, 360–365
(April 2002); doi:10.1038/ni772
| Abstract | Full Text (HTML/PDF) |
article
Dynamic visualization of a joint-specific autoimmune response through positron emission tomography
Brian T. Wipke, Zheng Wang, Joonyoung Kim, Timothy J. McCarthy and Paul M. Allen
Nature Immunology 3, 366–372
(April 2002); doi:10.1038/ni775
| Abstract | Full Text (HTML/PDF) |
news and views
Revival of the autoantibody model in rheumatoid arthritis
Toshio Hirano
Nature Immunology 3, 342–344
(April 2002); doi:10.1038/ni0402-342
| Abstract | Full Text (HTML/PDF) |
article
Human Toll-like receptor 4 recognizes host-specific LPS modifications
Adeline M. Hajjar, Robert K. Ernst and Jeff H. Tsai, Christopher B. Wilson and Samuel I. Miller
Nature Immunology 3, 354–359
(April 2002); doi:10.1038/ni777
| Abstract | Full Text (HTML/PDF) |
article
Down-regulation of diabetogenic CD4+ T cells by a soluble dimeric peptide-MHC class II chimera
Sofia Casares, Alicia Hurtado, Robert C. McEvoy, Adelaida Sarukhan, Harald von Boehmer and Teodor-Doru Brumeanu
Nature Immunology 3, 383–391
(April 2002); doi:10.1038/ni770
| Abstract | Full Text (HTML/PDF) |
article
TLR4, but not TLR2, mediates IFN-b-induced STAT1a/b-dependent gene expression in macrophages
Vladimir Toshchakov, Bryan W. Jones, Pin-Yu Perera, Karen Thomas, M. Joshua Cody, Shuling Zhang, Bryan R. G. Williams, Jennifer Major, Thomas A. Hamilton, Matthew J. Fenton and Stefanie N. Vogel
Nature Immunology 3, 392–398
(April 2002); doi:10.1038/ni774
| Abstract | Full Text (HTML/PDF) |
review article
VACCINES: SPINNING MOLECULAR IMMUNOLOGY INTO SUCCESSFUL IMMUNOTHERAPY
Drew M. Pardoll
Nature Reviews Immunology 2, 227–238
(April 2002); doi:10.1038/nri774
| Abstract | Full Text (HTML/PDF) |
review article
CYTOLYTIC PATHWAYS IN HAEMATOPOIETIC STEM-CELL TRANSPLANTATION
Marcel R. M. van den Brink and Steven J. Burakoff
Nature Reviews Immunology 2, 273–281
(April 2002); doi:10.1038/nri775
| Abstract | Full Text (HTML/PDF) |
article
CD39 is the dominant Langerhans cell-associated ecto-NTPDase: Modulatory roles in inflammation and immune responsiveness
Norikatsu Mizumoto, Tadashi Kumamoto, Simon C. Robson, Jean Sévigny, Hiroyuki Matsue, Keiichi Enjyoji and Akira Takashima
Nature Medicine 8, 358–365
(April 2002); doi:10.1038/nm0402-358
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news and views
The skinny on CD39 in immunity and inflammation
Richard D. Granstein
Nature Medicine 8, 336–338
(April 2002); doi:10.1038/nm0402-336
| Full Text (HTML/PDF) |
article
Inducer-stimulated Fas targets activated endothelium for destruction by anti-angiogenic thrombospondin-1 and pigment epithelium-derived factor
Olga V. Volpert, Tetiana Zaichuk, Wei Zhou, Frank Reiher, Thomas A. Ferguson, P. Michael Stuart, Mohammad Amin and Noel P. Bouck
Nature Medicine 8, 349–357
(April 2002); doi:10.1038/nm0402-349
| Abstract | Full Text (HTML/PDF) |
article
Efomycine M, a new specific inhibitor of selectin, impairs leukocyte adhesion and alleviates cutaneous inflammation
Michael P. Schön, Thomas Krahn, Margarete Schön, Maria-L. Rodriguez, Horst Antonicek, Jeanette E. Schultz, Ralf J. Ludwig, Thomas M. Zollner, Erwin Bischoff, Klaus-D. Bremm, Matthias Schramm, Kerstin Henninger, Roland Kaufmann, Harald P. M. Gollnick and Christina M. Parker and W.-Henning Boehncke
Nature Medicine 8, 366–372
(April 2002); doi:10.1038/nm0402-366
| Abstract | Full Text (HTML/PDF) |
news and views
Block the FAS, lose the fat
Charles V. Mobbs and Hideo Makimura
Nature Medicine 8, 335–336
(April 2002); doi:10.1038/nm0402-335
| Full Text (HTML/PDF) |
news and views
Not just research tools—proteasome inhibitors offer therapeutic promise
Alfred L. Goldberg and Kenneth Rock
Nature Medicine 8, 338–340
(April 2002); doi:10.1038/nm0402-338
| Full Text (HTML/PDF) |
review article
CONDITIONAL MOUSE MODELS OF SPORADIC CANCER
Jos Jonkers and Anton Berns
Nature Reviews Cancer 2, 251–265
(April 2002); doi:10.1038/nrc777
| Abstract | Full Text (HTML/PDF) |
review article
DEATH AND ANTI-DEATH: TUMOUR RESISTANCE TO APOPTOSIS
Frederik H. Igney and Peter H. Krammer
Nature Reviews Cancer 2, 277–288
(April 2002); doi:10.1038/nrc776
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review article
SCATTER-FACTOR AND SEMAPHORIN RECEPTORS: CELL SIGNALLING FOR INVASIVE GROWTH
Livio Trusolino and Paolo M. Comoglio
Nature Reviews Cancer 2, 289–300
(April 2002); doi:10.1038/nrc779
| Abstract | Full Text (HTML/PDF) |
review article
NF-kB IN CANCER: FROM INNOCENT BYSTANDER TO MAJOR CULPRIT
Michael Karin, Yixue Cao, Florian R. Greten and Zhi-Wei Li
Nature Reviews Cancer 2, 301–310
(April 2002); doi:10.1038/nrc780
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article
Genetic analysis of the mouse brain proteome
Joachim Klose, Christina Nock, Marion Herrmann, Kai Stühler, Katrin Marcus, Martin Blüggel, Eberhard Krause, Leonard C. Schalkwyk, Sohaila Rastan, Steve D.M. Brown, Konrad Büssow, Hans Lehrach and Heinz Himmelbauer
Nature Genetics 30, 385–393
(April 2002); doi:10.1038/ng861
| Abstract | Full Text (HTML/PDF) |
letter
Microtubule-associated protein 1A is a modifier of tubby hearing (moth1)
Akihiro Ikeda, Qing Yin Zheng, Aamir R. Zuberi, Kenneth R. Johnson, Jürgen K. Naggert and Patsy M. Nishina
Nature Genetics 30, 401–405
(April 2002); doi:10.1038/ng838
| First Paragraph | Full Text (HTML/PDF) |
news and views
Putting tubby on the MAP
Seth G.N. Grant
Nature Genetics 30, 347–348
(April 2002); doi:10.1038/ng0402-347
| Full Text (HTML/PDF) |
letter
c-fos regulates neuronal excitability and survival
Jianhua Zhang, Dongsheng Zhang, Jill Slane McQuade, Michael Behbehani, Joe Z. Tsien and Ming Xu
Nature Genetics 30, 416–420
(April 2002); doi:10.1038/ng859
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letter
Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus
Seung K. Kim, Licia Selleri, Joon S. Lee, Andrew Y. Zhang, Xueying Gu, Yakop Jacobs and Michael L. Cleary
Nature Genetics 30, 430–435
(April 2002); doi:10.1038/ng860
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letter
Cdc25b phosphatase is required for resumption of meiosis during oocyte maturation
A. Jeannine Lincoln, Dineli Wickramasinghe, Paula Stein, Richard M. Schultz, Mary Ellen Palko, Maria P. De De Miguel, Lino Tessarollo and Peter J. Donovan
Nature Genetics 30, 446–449
(April 2002); doi:10.1038/ng856
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news and views
Mitochondria, from cell death to proliferation
Pierre Rustin
Nature Genetics 30, 352–353
(April 2002); doi:10.1038/ng0402-352
| Full Text (HTML/PDF) |
article
CREB required for the stability of new and reactivated fear memories
Satoshi Kida, Sheena A. Josselyn, Sandra Peña de Ortiz, Jeffrey H. Kogan, Itzamarie Chevere, Shoichi Masushige and Alcino J. Silva
Nature Neuroscience 5, 348–355
(April 2002); doi:10.1038/nn819
| Abstract | Full Text (HTML/PDF) |
article
Memory enhancement and formation by atypical PKM activity in Drosophila melanogaster
Eric A. Drier, Marcela K. Tello, Maureen Cowan, Priscilla Wu, Nancy Blace, Todd Charlton Sacktor and Jerry C.P. Yin
Nature Neuroscience 5, 316–324
(April 2002); doi:10.1038/nn820
| Abstract | Full Text (HTML/PDF) |
brief communication
Protein kinase Mz is necessary and sufficient for LTP maintenance
Douglas S.F. Ling, Larry S. Benardo, Peter A. Serrano, Nancy Blace, Matthew T. Kelly, John F. Crary and Todd C. Sacktor
Nature Neuroscience 5, 295–296
(April 2002); doi:10.1038/nn829
| First Paragraph | Full Text (HTML/PDF) |
news and views
Flies put the buzz back into long-term-potentiation
Ole Paulsen and Richard G. M. Morris
Nature Neuroscience 5, 289–290
(April 2002); doi:10.1038/nn0402-289
| Full Text (HTML/PDF) |
article
Cooperation between independent hippocampal synapses is controlled by glutamate uptake
Nina Arnth-Jensen, Denis Jabaudon and Massimo Scanziani
Nature Neuroscience 5, 325–331
(April 2002); doi:10.1038/nn825
| Abstract | Full Text (HTML/PDF) |
news and views
A broad view of glutamate spillover
Jeffrey S. Diamond
Nature Neuroscience 5, 291–292
(April 2002); doi:10.1038/nn0402-291
| Full Text (HTML/PDF) |
brief communication
Leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K+ channels
Lynne J. Shanley, Andrew J. Irving, Mark G. Rae, Mike L.J. Ashford and Jenni Harvey
Nature Neuroscience 5, 299–300
(April 2002); doi:10.1038/nn824
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review article
NEURAL INDUCTION, THE DEFAULT MODEL AND EMBRYONIC STEM CELLS
Ignacio Muñoz-Sanjuán and Ali H. Brivanlou
Nature Reviews Neuroscience 3, 271–280
(April 2002); doi:10.1038/nrn786
| Abstract | Full Text (HTML/PDF) |
review article
g-SECRETASE, NOTCH, Ab AND ALZHEIMER'S DISEASE: WHERE DO THE PRESENILINS FIT IN?
Sangram S. Sisodia and Peter H. St George-Hyslop
Nature Reviews Neuroscience 3, 281–290
(April 2002); doi:10.1038/nrn785
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review article
NEW CONCEPTS IN THE IMMUNOPATHOGENESIS OF MULTIPLE SCLEROSIS
Bernhard Hemmer, Juan J. Archelos and Hans-Peter Hartung
Nature Reviews Neuroscience 3, 291–301
(April 2002); doi:10.1038/nrn784
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research article
Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors
Birgit Schoeberl, Claudia Eichler-Jonsson, Ernst Dieter Gilles and Gertraud Müller
Nature Biotechnology 20, 370–375
(April 2002); doi:10.1038/nbt0402-370
| Abstract | Full Text (HTML/PDF) |
Research News
Trading “wet-work” for network
Vipul Periwal and Zoltan Szallasi
Nature Biotechnology 20, 345–346
(April 2002); doi:10.1038/nbt0402-345
| Full Text (HTML/PDF) |
research article
Multiplexed protein profiling on microarrays by rolling-circle amplification
Barry Schweitzer, Scott Roberts, Brian Grimwade, Weiping Shao, Minjuan Wang, Qin Fu, Quiping Shu, Isabelle Laroche, Zhimin Zhou, Velizar T. Tchernev, Jason Christiansen, Mark Velleca and Stephen F. Kingsmore
Nature Biotechnology 20, 359–365
(April 2002); doi:10.1038/nbt0402-359
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research article
Identification of genes that function in the TNF-a-mediated apoptotic pathway using randomized hybrid ribozyme libraries
Hiroaki Kawasaki, Reiko Onuki, Eigo Suyama and Kazunari Taira
Nature Biotechnology 20, 376–380
(April 2002); doi:10.1038/nbt0402-376
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letter
Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site
Christopher Pargellis, Liang Tong, Laurie Churchill, Pier F. Cirillo, Thomas Gilmore, Anne G. Graham, Peter M. Grob, Eugene R. Hickey, Neil Moss, Susan Pav and John Regan
Nature Structural Biology 9, 268–272
(April 2002); doi:10.1038/nsb770
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letter
Crystal structure of a transition state mimic of the catalytic subunit of cAMP-dependent protein kinase
Madhusudan, Pearl Akamine, Nguyen-Huu Xuong and Susan S. Taylor
Nature Structural Biology 9, 273–277
(April 2002); doi:10.1038/nsb780
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letter
Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation
Natalia Beglova, Stephen C. Blacklow, Junichi Takagi and Timothy A. Springer
Nature Structural Biology 9, 282–287
(April 2002); doi:10.1038/nsb779
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letter
Structural basis of BLyS receptor recognition
Deena A. Oren, Yuling Li, Yulia Volovik, Tina S. Morris, Chhaya Dharia, Kalyan Das, Olga Galperina, Reiner Gentz and Eddy Arnold
Nature Structural Biology 9, 288–292
(April 2002); doi:10.1038/nsb769
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news and views
How calpain is activated by calcium
Ahmad Khorchid and Mitsuhiko Ikura
Nature Structural Biology 9, 239–241
(April 2002); doi:10.1038/nsb0402-239
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news and views
Single-handed recognition of a sorting traffic motif by the GGA proteins
Tom Kirchhausen
Nature Structural Biology 9, 241–244
(April 2002); doi:10.1038/nsb0402-241
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review article
PXR, CAR AND DRUG METABOLISM
Timothy M. Willson and Steven A. Kliewer
Nature Reviews Drug Discovery 1, 259–266
(April 2002); doi:10.1038/nrd753
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review article
OBESITY THERAPY: ALTERING THE ENERGY INTAKE-AND-EXPENDITURE BALANCE SHEET
Vivion E. F. Crowley, Giles S. H. Yeo and Stephen O'Rahilly
Nature Reviews Drug Discovery 1, 276–286
(April 2002); doi:10.1038/nrd770
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perspectives
TIMELINE: Protein kinases — the major drug targets of the twenty-first century?
Philip Cohen
Nature Reviews Drug Discovery 1, 309–315
(April 2002); doi:10.1038/nrd773
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