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Research library: browse by date

July 2002

2002: December | November | October | September | August | July | June | May | April | March | February | January

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The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.

Click here for free access to the 'Featured Articles' section, with new articles every week.

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letters to nature
Synthetic hosts by monomolecular imprinting inside dendrimers
Steven C. Zimmerman, Michael S. Wendland, Neal A. Rakow, Ilya Zharov and Kenneth S. Suslick
Nature 418, 399–403
(25 July 2002); doi:10.1038/nature00877
| First Paragraph | Full Text (HTML / PDF) |

news and views
Chemistry: Much binding in the lab
Andrew D. Hamilton
Nature 418, 375–376
(25 July 2002); doi:10.1038/418375a
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letters to nature
Post-translational disruption of dystroglycan-ligand interactions in congenital muscular dystrophies
Daniel E. Michele, Rita Barresi, Motoi Kanagawa, Fumiaki Saito, Ronald D. Cohn, Jakob S. Satz, James Dollar, Ichizo Nishino, Richard I. Kelley, Hannu Somer, Volker Straub, Katherine D. Mathews, Steven A. Moore and Kevin P. Campbell
Nature 418, 417–421
(25 July 2002); doi:10.1038/nature00837
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letters to nature
Deletion of brain dystroglycan recapitulates aspects of congenital muscular dystrophy
Steven A. Moore, Fumiaki Saito, Jianguo Chen, Daniel E. Michele, Michael D. Henry, Albee Messing, Ronald D. Cohn, Susan E. Ross-Barta, Steve Westra, Roger A. Williamson, Toshinori Hoshi and Kevin P. Campbell
Nature 418, 421–425
(25 July 2002); doi:10.1038/nature00838
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news and views
Neurobiology: Full circle to cobbled brain
M. Elizabeth Ross
Nature 418, 376–377
(25 July 2002); doi:10.1038/418376a
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letters to nature
E3 ubiquitin ligase that recognizes sugar chains
Yukiko Yoshida, Tomoki Chiba, Fuminori Tokunaga, Hiroshi Kawasaki, Kazuhiro Iwai, Toshiaki Suzuki, Yukishige Ito, Koji Matsuoka, Minoru Yoshida, Keiji Tanaka and Tadashi Tai
Nature 418, 438–442
(25 July 2002); doi:10.1038/nature00890
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news and views
Genetics: Inherit the wheeze
Jeffrey M. Drazen and Scott T. Weiss
Nature 418, 383–384
(25 July 2002); doi:10.1038/418383a
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letters to nature
Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness
Paul Van Eerdewegh, Randall D. Little, Josée Dupuis, Richard G. Del Mastro, Kathy Falls, Jason Simon, Dana Torrey, Sunil Pandit, Joyce McKenny, Karen Braunschweiger, Alison Walsh, Ziying Liu, Brooke Hayward, Colleen Folz, Susan P. Manning, Alicia Bawa, Lisa Saracino, Michelle Thackston, Youssef Benchekroun, Neva Capparell, Mei Wang, Ron Adair, Yun Feng, JoAnn Dubois, Michael G. FitzGerald, Hui Huang, René Gibson, Kristina M. Allen, Alex Pedan, Melvyn R. Danzig, Shelby P. Umland, Robert W. Egan, Francis M. Cuss, Steuart Rorke, Joanne B. Clough, John W. Holloway, Stephen T. Holgate and Tim P. Keith
Nature 418, 426–430
(25 July 2002); doi:10.1038/nature00878
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letters to nature
Distinct molecular mechanism for initiating TRAF6 signalling
Hong Ye, Joseph R. Arron, Betty Lamothe, Maurizio Cirilli, Takashi Kobayashi, Nirupama K. Shevde, Deena Segal, Oki K. Dzivenu, Masha Vologodskaia, Mijung Yim, Khoi Du, Sujay Singh, J. Wesley Pike, Bryant G. Darnay, Yongwon Choi and Hao Wu
Nature 418, 443–447
(25 July 2002); doi:10.1038/nature00888
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article
Filamin A-interacting protein (FILIP) regulates cortical cell migration out of the ventricular zone
Takashi Nagano, Takunari Yoneda, Yumiko Hatanaka, Chikara Kubota, Fujio Murakami and Makoto Sato
Nature Cell Biology 4, 495–501
(July 2002); doi:10.1038/ncb808
| Abstract | Full Text (HTML/PDF) |

brief communication
Nucleophosmin regulates the stability and transcriptional activity of p53
Emanuela Colombo, Jean-Christophe Marine, Davide Danovi, Brunangelo Falini and Pier Giuseppe Pelicci
Nature Cell Biology 4, 529–533
(July 2002); doi:10.1038/ncb814
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brief communication
The Vps27p-Hse1p complex binds ubiquitin and mediates endosomal protein sorting
Patricia S. Bilodeau, Jennifer L. Urbanowski, Stanley C. Winistorfer and Robert C. Piper
Nature Cell Biology 4, 534–539
(July 2002); doi:10.1038/ncb815
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review article
Synaptotagmin: A Ca2+ sensor that triggers exocytosis?
Ok-Ho Shin, Josep Rizo and Thomas C. Südhof
Nature Neuroscience 5, 649–656
(July 2002); doi:10.1038/nn869
| Abstract | Full Text (HTML/PDF) |

article
TH cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes
Orly Avni, Dong Lee, Fernando Macian, Susanne J. Szabo, Laurie H. Glimcher and Anjana Rao
Nature Immunology 3, 643–651
(July 2002); doi:10.1038/ni808
| Abstract | Full Text (HTML/PDF) |

article
Human epithelial cells trigger dendritic cell-mediated allergic inflammation by producing TSLP
Vassili Soumelis, Pedro A. Reche, Holger Kanzler, Wei Yuan, Gina Edward, Bernhart Homey, Michel Gilliet, Steve Ho, Svetlana Antonenko, Annti Lauerma, Kathleen Smith, Daniel Gorman, Sandra Zurawski, Jon Abrams, Satish Menon, Terri McClanahan, Rene de Waal-Malefyt, Fernando Bazan, Robert A. Kastelein and Yong-Jun Liu
Nature Immunology 3, 673–680
(July 2002); doi:10.1038/ni805
| Abstract | Full Text (HTML/PDF) |

news and views
TSLP: finally in the limelight
Warren J. Leonard
Nature Immunology 3, 605–607
(July 2002); doi:10.1038/ni0702-605
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article
Essential role of MD-2 in LPS responsiveness and TLR4 distribution
Yoshinori Nagai, Sachiko Akashi, Masakazu Nagafuku, Masato Ogata, Yoichiro Iwakura, Shizuo Akira, Toshio Kitamura, Atsushi Kosugi, Masao Kimoto and Kensuke Miyake
Nature Immunology 3, 667–672
(July 2002); doi:10.1038/ni809
| Abstract | Full Text (HTML/PDF) |

article
Hlx is induced by and genetically interacts with T-bet to promote heritable TH1 gene induction
Alan C. Mullen, Anne S. Hutchins, Frances A. High, Hubert W. Lee, Kara J. Sykes, Lewis A. Chodosh and Steven L. Reiner
Nature Immunology 3, 652–658
(July 2002); doi:10.1038/ni807
| Abstract | Full Text (HTML/PDF) |

review article
CTLA-4: new insights into its biological function and use in tumor immunotherapy
Jackson G. Egen, Michael S. Kuhns and James P. Allison
Nature Immunology 3, 611–618
(July 2002); doi:10.1038/ni0702-611
| Abstract | Full Text (HTML/PDF) |

review article
VAV proteins as signal integrators for multi-subunit immune-recognition receptors
Martin Turner and Daniel D. Billadeau
Nature Reviews Immunology 2, 476–486
(July 2002); doi:10.1038/nri840
| Abstract | Full Text (HTML/PDF) |

article
HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration
Christian Grimm, Andreas Wenzel, Matthias Groszer, Helmut Mayser, Mathias Seeliger, Marijana Samardzija, Christian Bauer, Max Gassmann and Charlotte E. Remé
Nature Medicine 8, 718–724
(July 2002); doi:10.1038/nm723
| Abstract | Full Text (HTML/PDF) |

article
Mitochondrial death protein Nix is induced in cardiac hypertrophy and triggers apoptotic cardiomyopathy
Martin G. Yussman, Tsuyoshi Toyokawa, Amy Odley, Roy A. Lynch, Guangyu Wu, Melissa C. Colbert, Bruce J. Aronow, John N. Lorenz, Gerald W. Dorn and Gerald W. Dorn II
Nature Medicine 8, 725–730
(July 2002); doi:10.1038/nm719
| Abstract | Full Text (HTML/PDF) |

article
Diet-induced insulin resistance in mice lacking adiponectin/ACRP30
Norikazu Maeda, Iichiro Shimomura, Ken Kishida, Hitoshi Nishizawa, Morihiro Matsuda, Hiroyuki Nagaretani, Naoki Furuyama, Hidehiko Kondo, Masahiko Takahashi, Yukio Arita, Ryutaro Komuro, Noriyuki Ouchi, Shinji Kihara, Yoshihiro Tochino, Keiichi Okutomi, Masato Horie, Satoshi Takeda, Toshifumi Aoyama, Tohru Funahashi and Yuji Matsuzawa
Nature Medicine 8, 731–737
(July 2002); doi:10.1038/nm724
| Abstract | Full Text (HTML/PDF) |

article
Inhibition of gastric inhibitory polypeptide signaling prevents obesity
Kazumasa Miyawaki, Yuichiro Yamada, Nobuhiro Ban, Yu Ihara, Katsushi Tsukiyama, Heying Zhou, Shimpei Fujimoto, Akira Oku, Kinsuke Tsuda, Shinya Toyokuni, Hiroshi Hiai, Wataru Mizunoya, Tohru Fushiki, Jens Juul Holst, Mitsuhiro Makino, Akira Tashita, Yukari Kobara, Yoshiharu Tsubamoto, Takayoshi Jinnouchi, Takahito Jomori and Yutaka Seino
Nature Medicine 8, 738–742
(July 2002); doi:10.1038/nm727
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article
The t(8;21) fusion protein, AML1-ETO, specifically represses the transcription of the p14ARF tumor suppressor in acute myeloid leukemia
Bryan Linggi, Carsten Müller-Tidow, Louis van de Locht, Ming Hu, John Nip, Hubert Serve, Wolfgang E. Berdel, Bert van der Reijden, Dawn E. Quelle, Janet D. Rowley, John Cleveland, Joop H. Jansen, Pier Paolo Pandolfi and Scott W. Hiebert
Nature Medicine 8, 743–750
(July 2002); doi:10.1038/nm726
| Abstract | Full Text (HTML/PDF) |

news and views
Burning up TNF toxicity for cancer therapy
Marcel Leist and Marja Jäättelä
Nature Medicine 8, 667–668
(July 2002); doi:10.1038/nm0702-667
| Full Text (HTML/PDF) |

review article
Charting HIV's remarkable voyage through the cell: Basic science as a passport to future therapy
Warner C. Greene and B. Matija Peterlin
Nature Medicine 8, 673–680
(July 2002); doi:10.1038/nm0702-673
| Abstract | Full Text (HTML/PDF) |

review article
LKB1 — A master tumour suppressor of the small intestine and beyond
Lina I. Yoo, Daniel C. Chung and Junying Yuan
Nature Reviews Cancer 2, 529–535
(July 2002); doi:10.1038/nrc843
| Abstract | Full Text (HTML/PDF) |

letter
Mutations in SUFU predispose to medulloblastoma
Michael D. Taylor, Ling Liu, Corey Raffel, Chi-chung Hui, Todd G. Mainprize, Xiaoyun Zhang, Ron Agatep, Sharon Chiappa, Luzhang Gao, Anja Lowrance, Aihau Hao, Alisa M. Goldstein, Theodora Stavrou, Stephen W. Scherer, Wieslaw T. Dura, Brandon Wainwright, Jeremy A. Squire, James T. Rutka and David Hogg
Nature Genetics 31, 306–310
(July 2002); doi:10.1038/ng916
| First Paragraph | Full Text (HTML/PDF) |

letter
Placental a2-adrenoceptors control vascular development at the interface between mother and embryo
Melanie Philipp, Marc E. Brede, Kerstin Hadamek, Manfred Gessler, Martin J. Lohse and Lutz Hein
Nature Genetics 31, 311–315
(July 2002); doi:10.1038/ng919
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letter
Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes
Shojiro Kikuchi, Masaki Hata, Kanehisa Fukumoto, Yukari Yamane, Takeshi Matsui, Atsushi Tamura, Shigenobu Yonemura, Hisakazu Yamagishi, Dietrich Keppler, Shoichiro Tsukita and Sachiko Tsukita
Nature Genetics 31, 320–325
(July 2002); doi:10.1038/ng905
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news and views
TOUCHINGbase
Nature Genetics 31, 231
(July 2002); doi:10.1038/ng0702-231
| Full Text (HTML/PDF) |

review article
Organogenesis: Patterning the vertebrate heart
Richard P. Harvey
Nature Reviews Genetics 3, 544–556
(July 2002); doi:10.1038/nrg843
| Abstract | Full Text (HTML/PDF) |

review article
Synaptotagmin function in dense core vesicle exocytosis studied in cracked pc12 cells
Jackson G. Egen, Michael S. Kuhns and James P. Allison
Nature Immunology 3, 611–618
(July 2002); doi:10.1038/ni0702-611
| Abstract | Full Text (HTML/PDF) |

letter
Structural basis for the accessory protein recruitment by the g-adaptin ear domain
Terukazu Nogi, Yoko Shiba, Masato Kawasaki, Tomoo Shiba, Naohiro Matsugaki, Noriyuki Igarashi, Mamoru Suzuki, Ryuichi Kato, Hiroyuki Takatsu, Kazuhisa Nakayama and Soichi Wakatsuki
Nature Structural Biology 9, 527–531
(July 2002); doi:10.1038/nsb808
| First Paragraph | Full Text (HTML/PDF) |

letter
Phosphoregulation of sorting signal-VHS domain interactions by a direct electrostatic mechanism
Yukio Kato, Saurav Misra, Rosa Puertollano, James H. Hurley and Juan S. Bonifacino
Nature Structural Biology 9, 532–536
(July 2002); doi:10.1038/nsb807
| First Paragraph | Full Text (HTML/PDF) |

letter to nature
Identification of genes expressed in C. elegans touch receptor neurons
Yun Zhang, Charles Ma, Thomas Delohery, Brian Nasipak, Barrett C. Foat, Alexander Bounoutas, Harmen J. Bussemaker, Stuart K. Kim and Martin Chalfie
Nature 418, 331–335
(18 July 2002); doi:10.1038/nature00891
| First Paragraph | Full Text (HTML/PDF) |

letter to nature
Synaptotagmins I and IV promote transmitter release independently of Ca2+ binding in the C2A domain
Iain M. Robinson, Ravi Ranjan and Thomas L. Schwarz
Nature 418, 336–340
(18 July 2002); doi:10.1038/nature00915
| First Paragraph | Full Text (HTML/PDF) |

letter to nature
The C2B Ca2+-binding motif of synaptotagmin is required for synaptic transmission in vivo
J. M. Mackler, J. A. Drummond, C. A. Loewen, I. M. Robinson and N. E. Reist
Nature 418, 340–344
(18 July 2002); doi:10.1038/nature00846
| First Paragraph | Full Text (HTML/PDF) |

letter to nature
Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex
Travis H. Stracker, Christian T. Carson and Matthew D. Weitzman
Nature 418, 348–352
(18 July 2002); doi:10.1038/nature00863
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letter to nature
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
Su-Ju Lin, Matt Kaeberlein, Alex A. Andalis, Lori A. Sturtz, Pierre-Antoine Defossez, Valeria C. Culotta, Gerald R. Fink and Leonard Guarente
Nature 418, 344–348
(18 July 2002); doi:10.1038/nature00829
| First Paragraph | Full Text (HTML/PDF) |

news and views
Longevity: Don't hold your breath
Siu Sylvia Lee and Gary Ruvkun
Nature 418, 287–288
(18 July 2002); doi:10.1038/418287a
| Full Text (HTML/PDF) |

brief communication
Distinct roles for cyclins E and A during DNA replication complex assembly and activation
D Coverley, H Laman & R A Laskey
Nature Cell Biology 4, 523–528
(July 2002); doi:10.1038/ncb813
| First Paragraph | Full Text (HTML/PDF) |

brief communication
The role of NFAT transcription factors in integrin-mediated carcinoma invasion
Sebastien Jauliac, Cristina López-Rodriguez, Leslie M. Shaw, Lawrence F. Brown, Anjana Rao and Alex Toker
Nature Cell Biology 4, 540–544
(July 2002); doi:10.1038/ncb816
| First Paragraph | Full Text (HTML/PDF) |

review article
Protease degradomics: A new challenge for proteomics
Carlos López-Otín and Christopher M. Overall
Nature Reviews Molecular Cell Biology 3, 509–519
(July 2002); doi:10.1038/nrm858
| Abstract | Full Text (HTML/PDF) |

review article
BAFF: A fundamental survival factor for B cells
Fabienne Mackay and Jeffrey L. Browning
Nature Reviews Immunology 2, 465–475
(July 2002); doi:10.1038/nri844
| Abstract | Full Text (HTML/PDF) |

article
Loss of HIF-2a and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice
Veerle Compernolle, Koen Brusselmans, Till Acker, Peter Hoet, Marc Tjwa, Heike Beck, Stéphane Plaisance, Yuval Dor, Eli Keshet, Florea Lupu, Benoit Nemery, Mieke Dewerchin, Paul Van Veldhoven, Karl Plate, Lieve Moons, Désiré Collen and Peter Carmeliet
Nature Medicine 8, 702–710
(July 2002); doi:10.1038/nm721
| Abstract | Full Text (HTML/PDF) |

news and views
Extra Rabs unsnarl a lipid traffic jam
Martin O. Bergo and Stephen G. Young
Nature Medicine 8, 662–664
(July 2002); doi:10.1038/nm0702-662
| Full Text (HTML/PDF) |

article
Genome-wide binding map of the histone deacetylase Rpd3 in yeast
Siavash K. Kurdistani, Daniel Robyr, Saeed Tavazoie and Michael Grunstein
Nature Genetics 31, 248–254
(July 2002); doi:10.1038/ng907
| Abstract | Full Text (HTML/PDF) |

letter
Truncating mutations of RB1CC1 in human breast cancer
Tokuhiro Chano, Keiichi Kontani, Koji Teramoto, Hidetoshi Okabe and Shiro Ikegawa
Nature Genetics 31, 285–288
(July 2002); doi:10.1038/ng911
| First Paragraph | Full Text (HTML/PDF) |

review article
Organogenesis: Coordinating early kidney development: lessons from gene targeting
Seppo Vainio and Yanfeng Lin
Nature Reviews Genetics 3, 533–543
(July 2002); doi:10.1038/nrg842
| Abstract | Full Text (HTML/PDF) |

article
DARPP-32 and regulation of the ethanol sensitivity of NMDA receptors in the nucleus accumbens
R. E. Maldve, T. A. Zhang, K. Ferrani-Kile, S. S. Schreiber, M. J. Lippmann, G. L. Snyder, A. A. Fienberg, S. W. Leslie, R. A. Gonzales and R. A. Morrisett
Nature Neuroscience 5, 641–648
(July 2002); doi:10.1038/nn877
| Abstract | Full Text (HTML/PDF) |

news and views
NMDA receptors lose their inhibitions
David M. Lovinger
Nature Neuroscience 5, 614–616
(July 2002); doi:10.1038/nn0702-614
| Full Text (HTML/PDF) |

review article
Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug
Renaud Capdeville, Elisabeth Buchdunger, Juerg Zimmermann and Alex Matter
Nature Reviews Drug Discovery 1, 493–502
(July 2002); doi:10.1038/nrd839
| Abstract | Full Text (HTML/PDF) |

letter to nature
Transmitter-evoked local calcium release stabilizes developing dendrites
Christian Lohmann, Karen L. Myhr and Rachel O. L. Wong
Nature 418, 177–181
(11 July 2002); doi:10.1038/nature00850
| First Paragraph | Full Text (HTML/PDF) |

letter to nature
TRPV3 is a calcium-permeable temperature-sensitive cation channel
Haoxing Xu, I. Scott Ramsey, Suhas A. Kotecha, Magdalene M. Moran, Jayhong A. Chong, Deborah Lawson, Pei Ge, Jeremiah Lilly, Inmaculada Silos-Santiago, Yu Xie, Peter S. DiStefano, Rory Curtis and David E. Clapham
Nature 418, 181–186
(11 July 2002); doi:10.1038/nature00882
| First Paragraph | Full Text (HTML/PDF) |

letter to nature
TRPV3 is a temperature-sensitive vanilloid receptor-like protein
G. D. Smith, M. J. Gunthorpe, R. E. Kelsell, P. D. Hayes, P. Reilly, P. Facer, J. E. Wright, J. C. Jerman, J.-P. Walhin, L. Ooi, J. Egerton, K. J. Charles, D. Smart, A. D. Randall, P. Anand and J. B. Davis
Nature 418, 186–190
(11 July 2002); doi:10.1038/nature00894
| First Paragraph | Full Text (HTML/PDF) |

letter to nature
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
Paola Scaffidi, Tom Misteli and Marco E. Bianchi
Nature 418, 191–195
(11 July 2002); doi:10.1038/nature00858
| First Paragraph | Full Text (HTML/PDF) |

letter to nature
Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes
Tian H. Chi, Mimi Wan, Keji Zhao, Ichiro Taniuchi, Lei Chen, Dan R. Littman and Gerald R. Crabtree
Nature 418, 195–199
(11 July 2002); doi:10.1038/nature00876
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letter to nature
Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment
Simon Brown, Isabelle Heinisch, Ewan Ross, Kate Shaw, Chris D. Buckley and John Savill
Nature 418, 200–203
(11 July 2002); doi:10.1038/nature00811
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news and views
Apoptosis: Repulsive encounters
Giovanna Chimini
Nature 418, 139–141
(11 July 2002); doi:10.1038/418139a
| Full Text (HTML/PDF) |

letter to nature
NMR analysis of a 900K GroEL-GroES complex
Jocelyne Fiaux, Eric B. Bertelsen, Arthur L. Horwich and Kurt Wüthrich
Nature 418, 207–211
(11 July 2002); doi:10.1038/nature00860
| First Paragraph | Full Text (HTML/PDF) |

insight: review article
The chemical repertoire of natural ribozymes
Jennifer A. Doudna and Thomas R. Cech
Nature 418, 222–228
(11 July 2002); doi:10.1038/418222a
| Summary | Full Text (HTML/PDF) |

insight: review article
The involvement of RNA in ribosome function
Peter B. Moore and Thomas A. Steitz
Nature 418, 229–235
(11 July 2002); doi:10.1038/418229a
| Summary | Full Text (HTML/PDF) |

insight: review article
RNA interference
Gregory J. Hannon
Nature 418, 244–251
(11 July 2002); doi:10.1038/418244a
| Summary | Full Text (HTML/PDF) |

insight: review article
Emerging clinical applications of RNA
Bruce A. Sullenger and Eli Gilboa
Nature 418, 252–258
(11 July 2002); doi:10.1038/418252a
| Summary | Full Text (HTML/PDF) |

brief communication
A PtdInsP3- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity
Orion D. Weiner, Paul O. Neilsen, Glenn D. Prestwich, Marc W. Kirschner, Lewis C. Cantley and Henry R. Bourne
Nature Cell Biology 4, 509–513
(July 2002); doi:10.1038/ncb811
| First Paragraph | Full Text (HTML/PDF) |

brief communication
Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils
Fei Wang, Paul Herzmark, Orion D. Weiner, Supriya Srinivasan, Guy Servant and Henry R. Bourne
Nature Cell Biology 4, 513–518
(July 2002); doi:10.1038/ncb810
| First Paragraph | Full Text (HTML/PDF) |

news and views
Leading the way
Ruedi Meili and Richard A. Firtel
Nature Cell Biology 4, E171
(July 2002); doi:10.1038/ncb0702-e171
| Full Text (HTML/PDF) |

review article
The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly
Martin Hetzer, Oliver J. Gruss and Iain W. Mattaj
Nature Cell Biology 4, E177
(July 2002); doi:10.1038/ncb0702-e177
| Abstract | Full Text (HTML/PDF) |

perspectives
Timeline: The strange case of the signal recognition particle
Karl S. Matlin
Nature Reviews Molecular Cell Biology 3, 538–542
(July 2002); doi:10.1038/nrm857
| Abstract | Full Text (HTML/PDF) |

article
G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4
Isabelle Petit, Martine Szyper-Kravitz, Arnon Nagler, Meir Lahav, Amnon Peled, Liliana Habler, Tanya Ponomaryov, Russell S. Taichman, Fernando Arenzana-Seisdedos, Nobutaka Fujii, Judith Sandbank, Dov Zipori and Tsvee Lapidot
Nature Immunology 3, 687–694
(July 2002); doi:10.1038/ni813
| Abstract | Full Text (HTML/PDF) |

article
Staphylococcus aureus extracellular adherence protein serves as anti-inflammatory factor by inhibiting the recruitment of host leukocytes
Triantafyllos Chavakis, Muzaffar Hussain, Sandip M. Kanse, Georg Peters, Reinhard G. Bretzel, Jan-Ingmar Flock, Mathias Herrmann and Klaus T. Preissner
Nature Medicine 8, 687–693
(July 2002); doi:10.1038/nm728
| Abstract | Full Text (HTML/PDF) |

news and views
Efp: A ring of independence?
Grzegorz Nalepa and J. Wade Harper
Nature Medicine 8, 661–662
(July 2002); doi:10.1038/nm0702-661
| Full Text (HTML/PDF) |

review article
Roles of heparan-sulphate glycosaminoglycans in cancer
Ram Sasisekharan, Zachary Shriver, Ganesh Venkataraman and Uma Narayanasami
Nature Reviews Cancer 2, 521–528
(July 2002); doi:10.1038/nrc842
| Abstract | Full Text (HTML/PDF) |

letter
Deletion in Catna2, encoding aN-catenin, causes cerebellar and hippocampal lamination defects and impaired startle modulation
Chankyu Park, William Falls, Jacqueline H. Finger, Chantal M. Longo-Guess and Susan L. Ackerman
Nature Genetics 31, 279–284
(July 2002); doi:10.1038/ng908
| First Paragraph | Full Text (HTML/PDF) |

review article
Organogenesis: Pancreatic organogenesis — developmental mechanisms and implications for therapy
Helena Edlund
Nature Reviews Genetics 3, 524–532
(July 2002); doi:10.1038/nrg841
| Abstract | Full Text (HTML/PDF) |

review article
Diversification of synaptic strength: presynaptic elements
Harold L. Atwood and Shanker Karunanithi
Nature Reviews Neuroscience 3, 497–516
(July 2002); doi:10.1038/nrn876
| Abstract | Full Text (HTML/PDF) |

review article
Nucleic-acid therapeutics: basic principles and recent applications
Joanna B. Opalinska and Alan M. Gewirtz
Nature Reviews Drug Discovery 1, 503–514
(July 2002); doi:10.1038/nrd837
| Abstract | Full Text (HTML/PDF) |

article
Pluripotency of mesenchymal stem cells derived from adult marrow
Yuehua Jiang, Balkrishna N. Jahagirdar, R. Lee Reinhardt, Robert E. Schwartz, C. Dirk Keene, Xilma R. Ortiz-Gonzalez, Morayma Reyes, Todd Lenvik, Troy Lund, Mark Blackstad, Jingbo Du, Sara Aldrich, Aaron Lisberg, Walter C. Low, David A. Largaespada and Catherine M. Verfaillie
Nature 418, 41–49
(5th July 2002); doi:10.1038/nature00870
| Abstract | Full Text (HTML/PDF) |

article
Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease
Jong-Hoon Kim, Jonathan M. Auerbach, José A. Rodríguez-Gómez, Iván Velasco, Denise Gavin, Nadya Lumelsky, Sang-Hun Lee, John Nguyen, Rosario Sánchez-Pernaute, Krys Bankiewicz and Ron McKay
Nature 418, 50–56
(5th July 2002); doi:10.1038/nature00900
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news and views
Biomedicine: Stem-cell competition
Stuart H. Orkin and Sean J. Morrison
Nature 418, 25–27
(5th July 2002); doi:10.1038/418025a
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Intracellular calcium stores regulate activity-dependent neuropeptide release from dendrites
Mike Ludwig, Nancy Sabatier, Philip M. Bull, Rainer Landgraf, Govindan Dayanithi and Gareth Leng
Nature 418, 85–89
(5th July 2002); doi:10.1038/nature00822
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letter to nature
Capacitance steps and fusion pores of small and large-dense-core vesicles in nerve terminals
Vitaly A. Klyachko and Meyer B. Jackson
Nature 418, 89–92
(5th July 2002); doi:10.1038/nature00852
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letter to nature
Dynamic interactions of cyclic AMP transients and spontaneous Ca2+ spikes
Yuliya V. Gorbunova and Nicholas C. Spitzer
Nature 418, 93–96
(5th July 2002); doi:10.1038/nature00835
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letter to nature
Determination of left-right patterning of the mouse embryo by artificial nodal flow
Shigenori Nonaka, Hidetaka Shiratori, Yukio Saijoh and Hiroshi Hamada
Nature 418, 96–99
(5th July 2002); doi:10.1038/nature00849
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news and views
Embryology: Fluid flow and broken symmetry
Claudio D. Stern
Nature 418, 29–30
(5th July 2002); doi:10.1038/418029a
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article
Myosin X is a downstream effector of PI(3)K during phagocytosis
Dianne Cox, Jonathan S. Berg, Michael Cammer, John O. Chinegwundoh, Benjamin M. Dale, Richard E. Cheney and Steven Greenberg
Nature Cell Biology 4, 469–477
(July 2002); doi:10.1038/ncb805
| Abstract | Full Text (HTML/PDF) |

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May the force be with you: Myosin-X in phagocytosis.
Philippe Chavrier
Nature Cell Biology 4, E169
(July 2002); doi:10.1038/ncb0702-e169
| Full Text (HTML/PDF) |

brief communication
Nuclear exclusion of Smad2 is a mechanism leading to loss of competence
Oliver H. Grimm and J. B. Gurdon
Nature Cell Biology 4, 519–522
(July 2002); doi:10.1038/ncb812
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news and views
Crème de la Kremen of Wnt signalling inhibition
Ute Rothbächer and Patrick Lemaire
Nature Cell Biology 4, E172
(July 2002); doi:10.1038/ncb0702-e172
| Full Text (HTML/PDF) |

review article
Mechanisms and functions of eph and ephrin signalling
Klas Kullander and Rüdiger Klein
Nature Reviews Molecular Cell Biology 3, 475–486
(July 2002); doi:10.1038/nrm856
| Abstract | Full Text (HTML/PDF) |

article
Linking innate and acquired immunity: divergent role of CD46 cytoplasmic domains in T cell-induced inflammation
Julien C. Marie, Anne L. Astier, Pierre Rivailler, Chantal Rabourdin-Combe, T. Fabian Wild and Branka Horvat
Nature Immunology 3, 659–666
(July 2002); doi:10.1038/ni810
| Abstract | Full Text (HTML/PDF) |

article
Nitric oxide in the human respiratory cycle
Timothy J. McMahon, Richard E. Moon, Ben P. Luschinger, Martha S. Carraway, Anne E. Stone, Bryant W. Stolp, Andrew J. Gow, John R. Pawloski, Paula Watke, David J. Singel, Claude A. Piantadosi and Jonathan S. Stamler
Nature Medicine 8, 711–717
(July 2002); doi:10.1038/nm718
| Abstract | Full Text (HTML/PDF) |

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Hemoglobin as a chariot for NO bioactivity
Paul Lane and Steven Gross
Nature Medicine 8, 657–658
(July 2002); doi:10.1038/nm0702-657
| Full Text (HTML/PDF) |

review article
The phosphatidylinositol 3-Kinase-AKT pathway in human cancer
Igor Vivanco and Charles L. Sawyers
Nature Reviews Cancer 2, 489–501
(July 2002); doi:10.1038/nrc839
| Abstract | Full Text (HTML/PDF) |

review article
Regulatory phases of early liver development: paradigms of organogenesis
Kenneth S. Zaret
Nature Reviews Genetics 3, 499–512
(July 2002); doi:10.1038/nrg837
| Abstract | Full Text (HTML/PDF) |

brief communication
Regulation of dendritic development by the ARF exchange factor ARNO
Delia J. Hernández-Deviez, James E. Casanova and Jean M. Wilson
Nature Neuroscience 5, 623–624
(July 2002); doi:10.1038/nn865
| First Paragraph | Full Text (HTML/PDF) |

review article
Proneural genes and the specification of neural cell types
Nicolas Bertrand, Diogo S. Castro and François Guillemot
Nature Reviews Neuroscience 3, 517–530
(July 2002); doi:10.1038/nrn874
| Abstract | Full Text (HTML/PDF) |

letter
Structure of human phosphatidylcholine transfer protein in complex with its ligand
Steven L. Roderick, Wayne W. Chan, Diana S. Agate, Laurence R. Olsen, Matt W. Vetting, K.R. Rajashankar and David E. Cohen
Nature Structural Biology 9, 507–511
(July 2002); doi:10.1038/nsb812
| First Paragraph | Full Text (HTML/PDF) |

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