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The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.
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article
Open channel structure of MscL and the gating mechanism of mechanosensitive channels
Eduardo Perozo, D. Marien Cortes, Pornthep Sompornpisut, Anna Kloda and Boris Martinac
Nature 418, 942–948
(29 August 2002); doi:10.1038/nature00992
| Summary | Full Text (HTML / PDF) |
letters to nature
Protein phosphatase 1 is a molecular constraint on learning and memory
David Genoux, Ursula Haditsch, Marlen Knobloch, Aubin Michalon, Daniel Storm and Isabelle M. Mansuy
Nature 418, 970–975
(29 August 2002); doi:10.1038/nature00928
| First Paragraph | Full Text (HTML / PDF) |
news and views
Cognitive neuroscience: The molecules of forgetfulness
Alcino J. Silva and Sheena A. Josselyn
Nature 418, 929–930
(29 August 2002); doi:10.1038/418929a
| Full Text (HTML / PDF) |
letters to nature
Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity
Ying Litingtung, Randall D. Dahn, Yina Li, John F. Fallon and Chin Chiang
Nature 418, 979–983
(29 August 2002); doi:10.1038/nature01033
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
T-cell engagement of dendritic cells rapidly rearranges MHC class II transport
Marianne Boes, Jan Cerny , Ramiro Massol, Marjolein Op den Brouw, Tom Kirchhausen, Jianzhu Chen and Hidde L. Ploegh
Nature 418, 983–988
(29 August 2002); doi:10.1038/nature01004
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane
Amy Chow, Derek Toomre, Wendy Garrett and Ira Mellman
Nature 418, 988–994
(29 August 2002); doi:10.1038/nature01006
| First Paragraph | Full Text (HTML / PDF) |
news and views
Immunology: Inside the professionals
Jonathan W. Yewdell and David C. Tscharke
Nature 418, 923–924
(29 August 2002); doi:10.1038/418923a
| Full Text (HTML / PDF) |
letters to nature
Reverse engineering of the giant muscle protein titin
Hongbin Li, Wolfgang A. Linke, Andres F. Oberhauser, Mariano Carrion-Vazquez, Jason G. Kerkvliet, Hui Lu, Piotr E. Marszalek and Julio M. Fernandez
Nature 418, 998–1002
(29 August 2002); doi:10.1038/nature00938
| First Paragraph | Full Text (HTML / PDF) |
news and views
Apoptosis: Sculpture of a fly's head
Jun R. Huh and Bruce A. Hay
Nature 418, 926–928
(29 August 2002); doi:10.1038/418926a
| Full Text (HTML / PDF) |
review article
Coordination of circadian timing in mammals
Steven M. Reppert and David R. Weaver
Nature 418, 935–941
(29 August 2002); doi:10.1038/nature00965
| Summary | Full Text (HTML / PDF) |
brief communication
Zebrafish trilobite identifies new roles for Strabismus in gastrulation and neuronal movements
Jason R. Jessen, Jacek Topczewski, Stephanie Bingham, Diane S. Sepich, Florence Marlow, Anand Chandrasekhar and Lilianna Solnica-Krezel
Nature Cell Biology 4, 610–615
(August 2002); doi:10.1038/ncb828
| First Paragraph | Full Text (HTML/PDF) |
brief communication
Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism
John M. Lambert, Que T. Lambert, Gary W. Reuther, Angeliki Malliri, David P. Siderovski, John Sondek, John G. Collard and Channing J. Der
Nature Cell Biology 4, 621–625
(August 2002); doi:10.1038/ncb833
| First Paragraph | Full Text (HTML/PDF) |
brief communication
An actin nucleation mechanism mediated by Bni1 and Profilin
Isabelle Sagot, Avital A. Rodal, James Moseley, Bruce L. Goode and David Pellman
Nature Cell Biology 4, 626–631
(August 2002); doi:10.1038/ncb834
| First Paragraph | Full Text (HTML/PDF) |
news and views
Chromosome instability: lessons from HIV
Jan Paul Medema and René H. Medema
Nature Cell Biology 4, E191
(August 2002); doi:10.1038/ncb0802-e191b
| Full Text (HTML/PDF) |
news and views
'ER we go
Rachel Smallridge
Nature Cell Biology 4, E193
(August 2002); doi:10.1038/ncb0802-e193
| Full Text (HTML/PDF) |
review article
Kinase- and phosphatase-anchoring proteins: harnessing the dynamic duo
Andrea L. Bauman and John D. Scott
Nature Cell Biology 4, E203
(August 2002); doi:10.1038/ncb0802-e203
| Abstract | Full Text (HTML/PDF) |
article
Origin of regulatory T cells with known specificity for antigen
Irina Apostolou, Adelaida Sarukhan, Ludger Klein and Harald von Boehmer
Nature Immunology 3, 756–763
(August 2002); doi:10.1038/ni816
| Abstract | Full Text (HTML/PDF) |
article
Negative regulation of CD45 by differential homodimerization of the alternatively spliced isoforms
Zheng Xu and Arthur Weiss
Nature Immunology 3, 764–771
(August 2002); doi:10.1038/ni822
| Abstract | Full Text (HTML/PDF) |
review article
Exosomes: Composition, Biogenesis and Function
Clotilde Théry, Laurence Zitvogel and Sebastian Amigorena
Nature Reviews Immunology 2, 569–579
(August 2002); doi:10.1038/nri855
| Abstract | Full Text (HTML/PDF) |
article
Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice
Lena Alexopoulou, Venetta Thomas, Markus Schnare, Yves Lobet, Juan Anguita, Robert T. Schoen, Ruslan Medzhitov, Erol Fikrig and Richard A. Flavell
Nature Medicine 8, 878–884
(August 2002); doi:10.1038/nm732
| Abstract | Full Text (HTML/PDF) |
article
Dystrophin deficiency markedly increases enterovirus-induced cardiomyopathy: A genetic predisposition to viral heart disease
Dingding Xiong, Gil-Hwan Lee, Cornel Badorff, Andrea Dorner, Sang Lee, Paul Wolf and Kirk U. Knowlton
Nature Medicine 8, 872–877
(August 2002); doi:10.1038/nm737
| Abstract | Full Text (HTML/PDF) |
article
Fully human, HLA-DR-specific monoclonal antibodies efficiently induce programmed death of malignant lymphoid cells
Zoltan A. Nagy, Bernd Hubner, Corinna Löhning, Robert Rauchenberger, Silke Reiffert, Elisabeth Thomassen-Wolf, Stefan Zahn, Sigmar Leyer, Eva M. Schier, Angelika Zahradnik, Christoph Brunner, Kurt Lobenwein, Benno Rattel, Michael Stanglmaier, Michael Hallek, Mark Wing, Steve Anderson, Matt Dunn, Titus Kretzschmar and Michael Tesar
Nature Medicine 8, 801–807
(August 2002); doi:10.1038/nm736
| Abstract | Full Text (HTML/PDF) |
news and views
DR's orders: Human antibody kills tumors by direct signaling
Dan L. Longo
Nature Medicine 8, 781–783
(August 2002); doi:10.1038/nm0802-781
| Full Text (HTML/PDF) |
article
Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
Haidong Dong, Scott E. Strome, Diva R. Salomao, Hideto Tamura, Fumiya Hirano, Dallas B. Flies, Patrick C. Roche, Jun Lu, Gefeng Zhu, Koji Tamada, Vanda A. Lennon, Esteban Celis and Lieping Chen
Nature Medicine 8, 793–800
(August 2002); doi:10.1038/nm730
| Abstract | Full Text (HTML/PDF) |
news and views
Protect the killer: CTLs need defenses against the tumor
Gordon J. Freeman, Arlene H. Sharpe and Vijay K. Kuchroo
Nature Medicine 8, 787–789
(August 2002); doi:10.1038/nm0802-787
| Full Text (HTML/PDF) |
article
Gene-expression profiles predict survival of patients with lung adenocarcinoma
David G. Beer, Sharon L.R. Kardia, Chiang-Ching Huang, Thomas J. Giordano, Albert M. Levin, David E. Misek, Lin Lin, Guoan Chen, Tarek G. Gharib, Dafydd G. Thomas, Michelle L. Lizyness, Rork Kuick, Satoru Hayasaka, Jeremy M.G. Taylor, Mark D. Iannettoni, Mark B. Orringer and Samir Hanash
Nature Medicine 8, 816–824
(August 2002); doi:10.1038/nm733
| Abstract | Full Text (HTML/PDF) |
news and views
A sharper image of SHP
Kristina Schoonjans and Johan Auwerx
Nature Medicine 8, 789–791
(August 2002); doi:10.1038/nm0802-789
| Full Text (HTML/PDF) |
news and views
Two-shot cocktail: Adenosine, dopamine and a twist of βγ
R. Adron Harris and Richard A. Morrisett
Nature Medicine 8, 777–779
(August 2002); doi:10.1038/nm0802-777
| Full Text (HTML/PDF) |
letter
Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H
Matthew C. Pickering, H. Terence Cook, Joanna Warren, Anne E. Bygrave, Jill Moss, Mark J. Walport and Marina Botto
Nature Genetics 31, 424–428
(August 2002); doi:10.1038/ng912
| First Paragraph | Full Text (HTML/PDF) |
news and views
Complement in glomerulonephritis
Thomas R. Welch
Nature Genetics 31, 333–334
(August 2002); doi:10.1038/ng933
| Full Text (HTML/PDF) |
progress
Molecular pathogenesis of human hepatocellular carcinoma
Snorri S. Thorgeirsson and Joe W. Grisham
Nature Genetics 31, 339–346
(August 2002); doi:10.1038/ng0802-339
| Abstract | Full Text (HTML/PDF) |
review article
Genetic approaches to studying energy balance: perception and integration
Gregory S. Barsh and Michael W. Schwartz
Nature Reviews Genetics 3, 589–600
(August 2002); doi:10.1038/nrg862
| Summary | Full Text (HTML / PDF) |
letter
Structure and catalytic mechanism of the E. coli chemotaxis phosphatase CheZ
Rui Zhao, Edward J. Collins, Robert B. Bourret and Ruth E. Silversmith
Nature Structural Biology 9, 570–575
(August 2002); doi:10.1038/nsb816
| First Paragraph | Full Text (HTML/PDF) |
news and views
Last, but not least
Philip Matsumura
Nature Structural Biology 9, 563–564
(August 2002); doi:10.1038/nsb0802-563
| Full Text (HTML/PDF) |
review article
The use of constitutively active GPCRs in drug discovery and functional genomics
Derek T. Chalmers and Dominic P. Behan
Nature Reviews Drug Discovery 1, 599–608
(August 2002); doi:10.1038/nrd872
| Summary | Full Text (HTML / PDF) |
article
Directionally selective calcium signals in dendrites of starburst amacrine cells
Thomas Euler, Peter B. Detwiler and Winfried Denk
Nature 418, 845–852
(22 August 2002); doi:10.1038/nature00931
| Summary | Full Text (HTML / PDF) |
letters to nature
Mechanism of magnesium activation of calcium-activated potassium channels
Jingyi Shi, Gayathri Krishnamoorthy, Yanwu Yang, Lei Hu, Neha Chaturvedi, Dina Harilal, Jun Qin and Jianmin Cui
Nature 418, 876–880
(22 August 2002); doi:10.1038/nature00941
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Multiple regulatory sites in large-conductance calcium-activated potassium channels
Xiao-Ming Xia, Xuhui Zeng and Christopher J. Lingle
Nature 418, 880–884
(22 August 2002); doi:10.1038/nature00956
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Patched acts catalytically to suppress the activity of Smoothened
J. Taipale, M. K. Cooper, T. Maiti and P. A. Beachy
Nature 418, 892–896
(22 August 2002); doi:10.1038/nature00989
| First Paragraph | Full Text (HTML / PDF) |
news and views
Immunology: A block at the toll gate
Tak W. Mak and Wen-Chen Yeh
Nature 418, 835–836
(22 August 2002); doi:10.1038/418835a
| Full Text (HTML / PDF) |
article
CRMP-2 binds to tubulin heterodimers to promote microtubule assembly
Yuko Fukata, Tomohiko J. Itoh, Toshihide Kimura, Céline Ménager, Takashi Nishimura, Takashi Shiromizu, Hiroyasu Watanabe, Naoyuki Inagaki, Akihiro Iwamatsu, Hirokazu Hotani and Kozo Kaibuchi
Nature Cell Biology 4, 583–591
(August 2002); doi:10.1038/ncb825
| Abstract | Full Text (HTML/PDF) |
news and views
Neuronal polarity: microtubules strike back
Peter W. Baas
Nature Cell Biology 4, E194
(August 2002); doi:10.1038/ncb0802-e194
| Full Text (HTML/PDF) |
article
Kinesin I-dependent cortical exclusion restricts pole plasm to the oocyte posterior
Byeong-Jik Cha, Laura R. Serbus, Birgit S. Koppetsch and William E. Theurkauf
Nature Cell Biology 4, 592–598
(August 2002); doi:10.1038/ncb832
| Abstract | Full Text (HTML/PDF) |
brief communication
Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling
Egle Avizienyte, Anne W. Wyke, Robert J. Jones, Gordon W. McLean, M. Andrew Westhoff, Valerie G. Brunton and Margaret C. Frame
Nature Cell Biology 4, 632–638
(August 2002); doi:10.1038/ncb829
| First Paragraph | Full Text (HTML/PDF) |
review article
Signal transduction and endocytosis: close encounters of many kinds
Alexander Sorkin and Mark von Zastrow
Nature Reviews Molecular Cell Biology 3, 600–614
(August 2002); doi:10.1038/nrm883
| Summary | Full Text (HTML / PDF) |
article
Disulfide exchange in domain 2 of CD4 is required for entry of HIV-1
Lisa J. Matthias, Patricia T.W. Yam, Xing-Mai Jiang, Nick Vandegraaff, Peng Li, Pantelis Poumbourios, Neil Donoghue and Philip J. Hogg
Nature Immunology 3, 727–732
(August 2002); doi:10.1038/ni815
| Abstract | Full Text (HTML/PDF) |
news and views
HIV entry: are all receptors created equal?
Mark A. Goldsmith and Robert W. Doms
Nature Immunology 3, 709–710
(August 2002); doi:10.1038/ni819
| Full Text (HTML/PDF) |
review article
Roles of Fc receptors in autoimmunity
Toshiyuki Takai
Nature Reviews Immunology 2, 580–592
(August 2002); doi:10.1038/nri856
| Summary | Full Text (HTML / PDF) |
perspectives
Opinion: Gene therapy of severe combined immunodeficiencies
Alain Fischer, Salima Hacein-Bey and Marina Cavazzana-Calvo
Nature Reviews Immunology 2, 615–621
(August 2002); doi:10.1038/nri859
| Summary | Full Text (HTML / PDF) |
article
Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist
Beth Borowsky, Margaret M. Durkin, Kristine Ogozalek, Mohammad R. Marzabadi, John DeLeon, Rainer Heurich, Harvey Lichtblau, Zoya Shaposhnik, Irena Daniewska, Thomas P. Blackburn, Theresa A. Branchek, Christophe Gerald, Pierre J. Vaysse and Carlos Forray
Nature Medicine 8, 825–830
(August 2002); doi:10.1038/nm741
| Abstract | Full Text (HTML/PDF) |
news and views
Rats lighten up with MCH antagonist
Michael W. Schwartz and Richard W. Gelling
Nature Medicine 8, 779–781
(August 2002); doi:10.1038/nm0802-779
| Full Text (HTML/PDF) |
review article
Live or let die: the cell's response to p53
Karen H. Vousden and Xin Lu
Nature Reviews Cancer 2, 594–604
(August 2002); doi:10.1038/nrc864
| Summary | Full Text (HTML / PDF) |
article
Revealing modular organization in the yeast transcriptional network
Jan Ihmels, Gilgi Friedlander, Sven Bergmann, Ofer Sarig, Yaniv Ziv and Naama Barkai
Nature Genetics 31, 370–377
(August 2002); doi:10.1038/ng941
| Abstract | Full Text (HTML/PDF) |
letter
Digenic inheritance of severe insulin resistance in a human pedigree
David B. Savage, Maura Agostini, Inês Barroso, Mark Gurnell, Jian'an Luan, Aline Meirhaeghe, Anne-Helen Harding, Gudrun Ihrke, Odelia Rajanayagam, Maria A. Soos, Stella George, Dirk Berger, E. Louise Thomas, Jimmy D. Bell, Karim Meeran, Richard J. Ross, Antonio Vidal-Puig, Nicholas J. Wareham, Stephen O'Rahilly, V. Krishna K. Chatterjee and Alan J. Schafer
Nature Genetics 31, 379–384
(August 2002); doi:10.1038/ng926
| First Paragraph | Full Text (HTML/PDF) |
brief communication
Hormonally regulated a4b2d GABAA receptors are a target for alcohol
Inger Sundstrom-Poromaa, Deborah H. Smith, Qi Hua Gong, Thomas N. Sabado, Xinshe Li, Adam Light, Martin Wiedmann, Keith Williams and Sheryl S. Smith
Nature Neuroscience 5, 721–722
(August 2002); doi:10.1038/nn888
| First Paragraph | Full Text (HTML/PDF) |
letters to nature
Involvement of DARPP-32 phosphorylation in the stimulant action of caffeine
Maria Lindskog, Per Svenningsson, Laura Pozzi, Yong Kim, Allen A. Fienberg, James A. Bibb, Bertil B. Fredholm, Angus C. Nairn, Paul Greengard and Gilberto Fisone
Nature 418, 774–778
(15 August 2002); doi:10.1038/nature00817
| First Paragraph | Full Text (HTML / PDF) |
news and views
Signal transduction: Positive feedback from coffee
Jean-Marie Vaugeois
Nature 418, 734–736
(15 August 2002); doi:10.1038/418734a
| Full Text (HTML / PDF) |
letters to nature
Distalization of the Drosophila leg by graded EGF-receptor activity
Gerard Campbell
Nature 418, 781–785
(15 August 2002); doi:10.1038/nature00971
| First Paragraph | Full Text (HTML / PDF) |
news and views
Developmental biology: Signalling legacies
Richard S. Mann and Fernando Casares
Nature 418, 737–739
(15 August 2002); doi:10.1038/418737a
| Full Text (HTML / PDF) |
letters to nature
Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck
Sharon Eden, Rajat Rohatgi, Alexandre V. Podtelejnikov, Matthias Mann and Marc W. Kirschner
Nature 418, 790–793
(15 August 2002); doi:10.1038/nature00859
| First Paragraph | Full Text (HTML / PDF) |
news and views
Cell motility: Braking WAVEs
Giles O. C. Cory and Anne J. Ridley
Nature 418, 732–733
(15 August 2002); doi:10.1038/418732a
| Full Text (HTML / PDF) |
letters to nature
Modulation of an RNA-binding protein by abscisic-acid-activated protein kinase
Jiaxu Li, Toshinori Kinoshita, Sona Pandey, Carl K.-Y. Ng, Steven P. Gygi, Ken-ichiro Shimazaki and Sarah M. Assmann
Nature 418, 793–797
(15 August 2002); doi:10.1038/nature00936
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Transcriptional co-activator PGC-1a drives the formation of slow-twitch muscle fibres
Jiandie Lin, Hai Wu, Paul T. Tarr, Chen-Yu Zhang, Zhidan Wu, Olivier Boss, Laura F. Michael, Pere Puigserver, Eiji Isotani, Eric N. Olson, Bradford B. Lowell, Rhonda Bassel-Duby and Bruce M. Spiegelman
Nature 418, 797–801
(15 August 2002); doi:10.1038/nature00904
| First Paragraph | Full Text (HTML / PDF) |
news and views
Physiology: Muscle regulator goes the distance
Richard Turner
Nature 418, 740
(15 August 2002); doi:10.1038/418740a
| Full Text (HTML / PDF) |
article
EphrinA1-induced cytoskeletal re-organization requires FAK and p130cas
Nigel Carter, Tetsuya Nakamoto, Hisamaru Hirai and Tony Hunter
Nature Cell Biology 4, 565–573
(August 2002); doi:10.1038/ncb823
| Abstract | Full Text (HTML/PDF) |
brief communication
Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-b
José G. Abreu, Nan I. Ketpura, Bruno Reversade and E. M. De Robertis
Nature Cell Biology 4, 599–604
(August 2002); doi:10.1038/ncb826
| First Paragraph | Full Text (HTML/PDF) |
article
Structure of human CD1b with bound ligands at 2.3 Å, a maze for alkyl chains
Stephan D. Gadola, Nathan R. Zaccai, Karl Harlos, Dawn Shepherd, Julio C. Castro-Palomino, Gerd Ritter, Richard R. Schmidt, E. Yvonne Jones and Vincenzo Cerundolo
Nature Immunology 3, 721–726
(August 2002); doi:10.1038/ni821
| Abstract | Full Text (HTML/PDF) |
news and views
The CD1b structure: antigen presentation adapts to a high-fat diet
Kayvan R. Niazi, Steven A. Porcelli and Robert L. Modlin
Nature Immunology 3, 703–704
(August 2002); doi:10.1038/ni0802-703
| Full Text (HTML/PDF) |
review article
Asthma: an epidemic of dysregulated immunity
Dale T. Umetsu, Jennifer J. McIntire, Omid Akbari, Claudia Macaubas and Rosemarie H. DeKruyff
Nature Immunology 3, 715–720
(August 2002); doi:10.1038/ni0802-715
| Abstract | Full Text (HTML/PDF) |
review article
Maintaining the norm: T-Cell homeostasis
Stephen C. Jameson
Nature Reviews Immunology 2, 547–556
(August 2002); doi:10.1038/nri853
| Summary | Full Text (HTML / PDF) |
article
Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2-ErbB3 receptors
Todd D. Camenisch, Joyce A. Schroeder, Judy Bradley, Scott E. Klewer and John A. McDonald
Nature Medicine 8, 850–855
(August 2002); doi:10.1038/nm742
| Abstract | Full Text (HTML/PDF) |
review article
Metastasis to bone: causes, consequences and therapeutic opportunities
Gregory R. Mundy
Nature Reviews Cancer 2, 584–593
(August 2002); doi:10.1038/nrc867
| Summary | Full Text (HTML / PDF) |
article
Paxillin binds schwannomin and regulates its density-dependent localization and effect on cell morphology
Cristina Fernandez-Valle, Yong Tang, Jerome Ricard, Alma Rodenas-Ruano, Anna Taylor, Elizabeth Hackler, John Biggerstaff and Jared Iacovelli
Nature Genetics 31, 354–362
(August 2002); doi:10.1038/ng930
| Abstract | Full Text (HTML/PDF) |
news and views
Strabismus shows the way
Alan Packer
Nature Genetics 31, 335
(August 2002); doi:10.1038/ng0802-335
| Full Text (HTML/PDF) |
article
Self-inhibition of olfactory bulb neurons
T. Caitlin Smith and Craig E. Jahr
Nature Neuroscience 5, 760–766
(August 2002); doi:10.1038/nn882
| Abstract | Full Text (HTML/PDF) |
review article
CDKS and CKIS: Molecular targets for tissue remodelling
Elizabeth G. Nabel
Nature Reviews Drug Discovery 1, 587–598
(August 2002); doi:10.1038/nrd869
| Summary | Full Text (HTML / PDF) |
review article
Endogenous kynurenines as targets for drug discovery and development
Trevor W. Stone and L. Gail Darlington
Nature Reviews Drug Discovery 1, 609–620
(August 2002); doi:10.1038/nrd870
| Summary | Full Text (HTML / PDF) |
original paper
Activation of NF-KAPPAB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications
C.S. Mitsiades, N. Mitsiades, V. Poulaki, R. Schlossman, M. Akiyama, D. Chauhan, T. Hideshima, S.P. Treon, N.C. Munshi, P.G. Richardson, K.C. Anderson
Oncogene 21, 5673–5683
(August 2002); doi:
| Abstract |
article
Structural changes in the calcium pump accompanying the dissociation of calcium
Chikashi Toyoshima and Hiromi Nomura
Nature 418, 605–611
(8 August 2002); doi:10.1038/nature00944
| Summary | Full Text (HTML / PDF) |
news and views
Structural biology: Calcium callisthenics
N. Michael Green and David H. MacLennan
Nature 418, 598–599
(8 August 2002); doi:10.1038/418598b
| Full Text (HTML / PDF) |
letters to nature
Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis
Petra Pandur, Matthias Läsche, Leonard M. Eisenberg and Michael Kühl
Nature 418, 636–641
(8 August 2002); doi:10.1038/nature00921
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
A component of the ARC/Mediator complex required for TGFb/Nodal signalling
Yoichi Kato, Raymond Habas, Yu Katsuyama, Anders M. Näär and Xi He
Nature 418, 641–646
(8 August 2002); doi:10.1038/nature00969
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Gut hormone PYY3-36 physiologically inhibits food intake
Rachel L. Batterham, Michael A. Cowley , Caroline J. Small, Herbert Herzog, Mark A. Cohen, Catherine L. Dakin, Alison M. Wren, Audrey E. Brynes, Malcolm J. Low, Mohammad A. Ghatei, Roger D. Cone and Stephen R. Bloom
Nature 418, 650–654
(8 August 2002); doi:10.1038/nature00887
| First Paragraph | Full Text (HTML / PDF) |
news and views
Obesity: Keeping hunger at bay
Michael W. Schwartz and Gregory J. Morton
Nature 418, 595–597
(8 August 2002); doi:10.1038/418595a
| Full Text (HTML / PDF) |
letters to nature
A naturally occurring MTA1 variant sequesters oestrogen receptor-a in the cytoplasm
Rakesh Kumar, Rui-An Wang, Abhijit Mazumdar, Amjad H. Talukder, Mahitosh Mandal, Zhibo Yang, Rozita Bagheri-Yarmand, Aysegul Sahin, Gabriel Hortobagyi, Liana Adam, Christopher J. Barnes and Ratna K. Vadlamudi
Nature 418, 654–657
(8 August 2002); doi:10.1038/nature00889
| First Paragraph | Full Text (HTML / PDF) |
article
b-Arrestins regulate a Ral-GDS-Ral effector pathway that mediates cytoskeletal reorganization
Moshmi Bhattacharya, Pieter H. Anborgh, Andy V. Babwah, Lianne B. Dale, Tomas Dobransky, Jeffery L. Benovic, Ross D. Feldman, Joseph M. Verdi, R. Jane Rylett and Stephen S. G. Ferguson
Nature Cell Biology 4, 547–555
(August 2002); doi:10.1038/ncb821
| Abstract | Full Text (HTML/PDF) |
brief communication
Myosin VI is required for E-cadherin-mediated border cell migration
Erika R. Geisbrecht and Denise J. Montell
Nature Cell Biology 4, 616–620
(August 2002); doi:10.1038/ncb830
| First Paragraph | Full Text (HTML/PDF) |
news and views
Formins initiate new actin filaments
Thomas D. Pollard
Nature Cell Biology 4, E191
(August 2002); doi:10.1038/ncb0802-e191a
| Full Text (HTML/PDF) |
meeting report
Cell cycling? Check your brakes
Steven I. Reed
Nature Cell Biology 4, E199
(August 2002); doi:10.1038/ncb0802-e199
| First Paragraph | Full Text (HTML/PDF) |
review article
Plasticity and reprogramming of differentiated cells in amphibian regeneration
Jeremy P. Brockes and Anoop Kumar
Nature Reviews Molecular Cell Biology 3, 566–574
(August 2002); doi:10.1038/nrm881
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article
A nonredundant role for the adapter protein Shc in thymic T cell development
Li Zhang, Victoria Camerini, Timothy P. Bender and Kodi S. Ravichandran
Nature Immunology 3, 749–755
(August 2002); doi:10.1038/ni820
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Shc: a dominant player after ten seasons
Ed Palmer
Nature Immunology 3, 710–711
(August 2002); doi:10.1038/ni0802-710
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review article
The unconventional lifestyle of NKT Cells
Mitchell Kronenberg and Laurent Gapin
Nature Reviews Immunology 2, 557–568
(August 2002); doi:10.1038/nri854
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review article
The hare and the tortoise: an embryonic haematopoietic race
Isabelle Godin and Ana Cumano
Nature Reviews Immunology 2, 593–604
(August 2002); doi:10.1038/nri857
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article
Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1
Aernout Luttun, Marc Tjwa, Lieve Moons, Yan Wu, Anne Angelillo-Scherrer, Fang Liao, Janice A. Nagy, Andrea Hooper, Josef Priller, Bert De Klerck, Veerle Compernolle, Evis Daci, Peter Bohlen, Mieke Dewerchin, Jean-Marc Herbert, Roy Fava, Patrick Matthys, Geert Carmeliet, Désiré Collen, Harold F. Dvorak, Daniel J. Hicklin and Peter Carmeliet
Nature Medicine 8, 831–840
(August 2002); doi:10.1038/nm731
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article
Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1+ stem cells from bone-marrow microenvironment
Koichi Hattori, Beate Heissig, Yan Wu, Sergio Dias, Rafael Tejada, Barbara Ferris, Daniel J. Hicklin, Zhenping Zhu, Peter Bohlen, Larry Witte, Jan Hendrikx, Neil R. Hackett, Ronald G. Crystal, Malcolm A.S. Moore, Zena Werb, David Lyden and Shahin Rafii
Nature Medicine 8, 841–849
(August 2002); doi:10.1038/nm740
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VEGF receptor 1 stimulates stem-cell recruitment and new hope for angiogenesis therapies
Ulf Eriksson and Kari Alitalo
Nature Medicine 8, 775–777
(August 2002); doi:10.1038/nm0802-775
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review article
p73: Friend or foe in tumorigenesis
Gerry Melino, Vincenzo De Laurenzi and Karen H. Vousden
Nature Reviews Cancer 2, 605–615
(August 2002); doi:10.1038/nrc861
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review article
The Molecular and Genetic Basis of Neurological Tumours
Yuan Zhu and Luis F. Parada
Nature Reviews Cancer 2, 616–626
(August 2002); doi:10.1038/nrc866
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article
Urocortin-deficient mice show hearing impairment and increased anxiety-like behavior
Douglas E. Vetter, Chien Li, Lingyun Zhao, Angelo Contarino, M. Charles Liberman, George W. Smith, Yelena Marchuk, George F. Koob, Stephen F. Heinemann, Wylie Vale and Kuo-Fen Lee
Nature Genetics 31, 363–369
(August 2002); doi:10.1038/ng914
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brief communication
Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons
Yan Zhu, Tao Yu, Xiao-Chun Zhang, Takashi Nagasawa, Jane Y. Wu and Yi Rao
Nature Neuroscience 5, 719–720
(August 2002); doi:10.1038/nn881
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review article
SNAREs and munc18 in synaptic vesicle fusion
Josep Rizo and Thomas C. Südhof
Nature Reviews Neuroscience 3, 641–653
(August 2002); doi:10.1038/nrn898
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News and Views
MAPping p38 binding interactions
Elizabeth H. Cox
Nature Structural Biology 9, 569
(August 2002); doi:10.1038/nsb0802-569
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original paper
Raf-induced effects on the differentiation and apoptosis of skeletal myoblasts are determined by the level of Raf signaling: abrogation of apoptosis by Raf is downstream of caspase 3 activation
DeChant A.K., Dee K. and Weyman C.M.
Oncogene 21, 5268–5279
(8 August 2002); doi:10.1038/sj.onc.1205648
| Abstract |
original paper
A ligand-receptor pair that triggers a non-apoptotic form of programmed cell death
Castro-Obregón S., del Rio G., Chen S.F., Swanson R.A., Frankowski H., Rao R.V., Stoka V., Vesce S., Nicholls D.G. and Bredesen D.E.
Cell Death and Differentiation 9, 807–817
(August 2002); doi:10.1038/sj.cdd.4401035
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article
Functions of FGF signalling from the apical ectodermal ridge in limb development
Xin Sun, Francesca V. Mariani and Gail R. Martin
Nature 418, 501–508
(1 August 2002); doi:10.1038/nature00902
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letter
A re-examination of proximodistal patterning during vertebrate limb development
Andrew T. Dudley, María A. Ros and Clifford J. Tabin
Nature 418, 539–544
(1 August 2002); doi:10.1038/nature00945
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Developmental biology: Making progress with limb models
Denis Duboule
Nature 418, 492–493
(1 August 2002); doi:10.1038/418492a
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letter
Two-step binding mechanism for T-cell receptor recognition of peptide-MHC
Lawren C. Wu, Delphine S. Tuot, Daniel S. Lyons, K. Christopher Garcia and Mark M. Davis
Nature 418, 552–556
(1 August 2002); doi:10.1038/nature00920
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letter
APC-dependent proteolysis of the mitotic cyclin Clb2 is essential for mitotic exit
Ralph Wäsch and Frederick R. Cross
Nature 418, 556–562
(1 August 2002); doi:10.1038/nature00856
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Cell cycle: Oscillation sensation
David O. Morgan and James M. Roberts
Nature 418, 495–496
(1 August 2002); doi:10.1038/418495a
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letter
The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair
Karl-Peter Hopfner, Lisa Craig, Gabriel Moncalian, Robert A. Zinkel, Takehiko Usui, Barbara A. L. Owen, Annette Karcher, Brendan Henderson, Jean-Luc Bodmer, Cynthia T. McMurray, James P. Carney, John H. J. Petrini and John A. Tainer
Nature 418, 562–566
(1 August 2002); doi:10.1038/nature00922
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article
Molecular interpretation of ERK signal duration by immediate early gene products
Leon O. Murphy, Sallie Smith, Rey-Huei Chen, Diane C. Fingar and John Blenis
Nature Cell Biology 4, 556–564
(August 2002); doi:10.1038/ncb822
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Common sense signalling
Richard K. Assoian
Nature Cell Biology 4, E187
(August 2002); doi:10.1038/ncb0802-e187
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article
Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex
Enrico Brugnera, Lisa Haney, Cynthia Grimsley, Mingjian Lu, Scott F. Walk, Annie-Carole Tosello-Trampont, Ian G. Macara, Hiten Madhani, Gerald R. Fink and Kodimangalam S. Ravichandran
Nature Cell Biology 4, 574–582
(August 2002); doi:10.1038/ncb824
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news and views
GEF without a Dbl domain?
Vania M. M. Braga
Nature Cell Biology 4, E188
(August 2002); doi:10.1038/ncb0802-e188
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review article
ERM proteins and merlin: integrators at the cell cortex
Anthony Bretscher, Kevin Edwards and Richard G. Fehon
Nature Reviews Molecular Cell Biology 3, 586–599
(August 2002); doi:10.1038/nrm882
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article
Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation
Valentino Parravicini, Massimo Gadina, Martina Kovarova, Sandra Odom, Claudia Gonzalez-Espinosa, Yasuko Furumoto, Shinichiroh Saitoh, Lawrence E. Samelson, John J. O'Shea and Juan Rivera
Nature Immunology 3, 741–748
(August 2002); doi:10.1038/ni817
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Uncovering new complexities in mast cell signaling
Monica J.S. Nadler and Jean-Pierre Kinet
Nature Immunology 3, 707–708
(August 2002); doi:10.1038/ni0802-707
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article
PKC-b controls IkB kinase lipid raft recruitment and activation in response to BCR signaling
Thomas T. Su, Beichu Guo, Yuko Kawakami, Karen Sommer, Keun Chae, Lisa A. Humphries, Roberta M. Kato, Shin Kang, Lisa Patrone, Randolph Wall, Michael Teitell, Michael Leitges, Toshiaki Kawakami and David J. Rawlings
Nature Immunology 3, 780–786
(August 2002); doi:10.1038/ni823
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article
Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo
Simone Fulda, Wolfgang Wick, Michael Weller and Klaus-Michael Debatin
Nature Medicine 8, 808–815
(August 2002); doi:10.1038/nm735
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article
Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling
Takayuki Shindo, Ichiro Manabe, Yasushi Fukushima, Kazuyuki Tobe, Kenichi Aizawa, Saku Miyamoto, Keiko Kawai-Kowase, Nobuo Moriyama, Yasushi Imai, Hayato Kawakami, Hiroaki Nishimatsu, Takashi Ishikawa, Toru Suzuki, Hiroyuki Morita, Koji Maemura, Masataka Sata, Yasunobu Hirata, Masayuki Komukai, Hiroyuki Kagechika, Takashi Kadowaki, Masahiko Kurabayashi and Ryozo Nagai
Nature Medicine 8, 856–863
(August 2002); doi:10.1038/nm738
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article
Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma
Douglas A. Kuperman, Xiaozhu Huang, Laura L. Koth, Grace H. Chang, Gregory M. Dolganov, Zhou Zhu, Jack A. Elias, Dean Sheppard and David J. Erle
Nature Medicine 8, 885–889
(August 2002); doi:10.1038/nm734
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letter
Cblb is a major susceptibility gene for rat type 1 diabetes mellitus
Norihide Yokoi, Kajuro Komeda, He-Yao Wang, Hideki Yano, Kazuhiro Kitada, Yuka Saitoh, Yutaka Seino, Kazuki Yasuda, Tadao Serikawa and Susumu Seino
Nature Genetics 31, 391–394
(August 2002); doi:10.1038/ng927
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letter
PP1 binds Sara and negatively regulates Dpp signaling in Drosophila melanogaster
Daimark Bennett and Luke Alphey
Nature Genetics 31, 419–423
(August 2002); doi:10.1038/ng938
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review article
Genomics and natural language processing
Mark D. Yandell and William H. Majoros
Nature Reviews Genetics 3, 601–610
(August 2002); doi:10.1038/nrg861
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article
Rapid recruitment of NMDA receptor transport packets to nascent synapses
Philip Washbourne, Jennie E. Bennett and A. Kimberley McAllister
Nature Neuroscience 5, 751–759
(August 2002); doi:10.1038/nn883
| Abstract | Full Text (HTML/PDF) |
brief communication
A phosphatidylinositol 3-kinase-phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding
Allan Z. Zhao, Jjing-Ning Huan, Sandhya Gupta, Rekha Pal and Abhiram Sahu
Nature Neuroscience 5, 727–728
(August 2002); doi:10.1038/nn885
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research article
Neutrophil chemotaxis in linear and complex gradients of interleukin-8 formed in a microfabricated device
Noo Li Jeon, Harihara Baskaran, Stephan K. W. Dertinger, George M. Whitesides, Livingston Van De Water and Mehmet Toner
Nature Biotechnology 20, 826–830
(August 2002); doi:10.1038/nbt712
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article
Elevated JNK activation contributes to the pathogenesis of human brain tumors
Oncogene 21, 5038–5046
(August 2002); doi:10.1038/sj.onc.1205593
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