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The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.
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letters to nature
The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response
Hongwu Zheng, Han You, Xiao Zhen Zhou, Stephen A. Murray, Takafumi Uchida, Gerburg Wulf, Ling Gu, Xiaoren Tang, Kun Ping Lu and Zhi-Xiong Jim Xiao
Nature 419, 849–853
(24 October 2002); doi:10.1038/nature01116
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letters to nature
The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults
Paola Zacchi , Monica Gostissa, Takafumi Uchida, Clio Salvagno, Fabio Avolio, Stefano Volinia, Ze'ev Ronai, Giovanni Blandino, Claudio Schneider and Giannino Del Sal
Nature 419, 853–857
(24 October 2002); doi:10.1038/nature01120
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news and views
Cancer: Pinning a change on p53
Kevin M. Ryan and Karen H. Vousden An enzyme-induced conformational change is now implicated in activating the p53 protein, one of a cell's prime movers in preventing tumour development.
Nature 419, 795–797
(24 October 2002); doi:10.1038/419795a
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news and views
Cell biology: Survival in three dimensions
Kenneth M. Yamada and Katherine Clark Whether a cell lives or dies depends on various local cues. New work reveals that those cues include a cell's spatial relationship with its neighbours and polarized interactions with the adjacent extracellular matrix.
Nature 419, 790–791
(24 October 2002); doi:10.1038/419790a
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article
Chromatin-remodelling factor BRG1 selectively activates a subset of interferon-a-inducible genes
Mei Huang, Feng Qian, Yuanyu Hu, Chengeng Ang, Zhong Li and Zilong Wen
Nature Cell Biology 4, 774–781
(October 2002); doi:10.1038/ncb855
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article
Dmoesin controls actin-based cell shape and polarity during Drosophila melanogaster oogenesis
Cédric Polesello, Isabelle Delon, Philippe Valenti, Pierre Ferrer and François Payre
Nature Cell Biology 4, 782–789
(October 2002); doi:10.1038/ncb856
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news and views
A glimpse of coated vesicle creation? Well almost!
Francesca Santini and James H. Keen
Nature Cell Biology 4, E230
(October 2002); doi:10.1038/ncb1002-e230
| Full Text (HTML/PDF) |
review article
Furin at the cutting edge: From protein traffic to embryogenesis and disease
Gary Thomas
Nature Reviews Molecular Cell Biology 3, 753–766
(October 2002); doi:10.1038/nrm934
| Summary | Full Text (HTML/PDF) |
article
Staging and resetting T cell activation in SMACs
Benjamin A. Freiberg, Hannah Kupfer, William Maslanik, Joe Delli, John Kappler, Dennis M. Zaller and Abraham Kupfer
Nature Immunology 3, 911–917
(October 2002); doi:10.1038/ni836
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article
Molecular anatomy of antigen-specific CD8+ T cell engagement and synapse formation in vivo
Dorian B. McGavern, Urs Christen and Michael B.A. Oldstone
Nature Immunology 3, 918–925
(October 2002); doi:10.1038/ni843
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article
B cells regulate autoimmunity by provision of IL-10
Simon Fillatreau, Claire H. Sweenie, Mandy J. McGeachy, David Gray and Stephen M. Anderton
Nature Immunology 3, 944–950
(October 2002); doi:10.1038/ni833
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review article
Development of ab t cells in the human thymus
Hergen Spits
Nature Reviews Immunology 2, 760–772
(October 2002); doi:10.1038/nri913
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review article
Anti-inflammatory lipid mediators and insights into the resolution of inflammation
Toby Lawrence, Derek A. Willoughby and Derek W. Gilroy
Nature Reviews Immunology 2, 787–795
(October 2002); doi:10.1038/nri915
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article
Pepducin-based intervention of thrombin-receptor signaling and systemic platelet activation
Lidija Covic, Meghna Misra, Jehangir Badar, Christopher Singh and Athan Kuliopulos
Nature Medicine 8, 1161–1165
(October 2002); doi:10.1038/nm760
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news and views
Attacked from within, blood thins
Wadie F. Bahou
Nature Medicine 8, 1082–1083
(October 2002); doi:10.1038/nm1002-1082
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article
A futile metabolic cycle activated in adipocytes by antidiabetic agents
Hong-Ping Guan, Yong Li, Mette Valentin Jensen, Christopher B. Newgard, Claire M. Steppan and Mitchell A. Lazar
Nature Medicine 8, 1122–1128
(October 2002); doi:10.1038/nm780
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news and views
Oxidized lipid protects against sepsis
Niels C. Riedemann and Peter A. Ward
Nature Medicine 8, 1084–1085
(October 2002); doi:10.1038/nm1002-1084
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review article
c-myc: more than just a matter of life and death
Stella Pelengaris, Mike Khan and Gerard Evan
Nature Reviews Cancer 2, 764–776
(October 2002); doi:10.1038/nrc904
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article
Regulation of insulin action and pancreatic b-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1
Jun Nakae, William H. Biggs, III Tadahiro Kitamura, Webster K. Cavenee, Christopher V.E. Wright, Karen C. Arden and Domenico Accili
Nature Genetics 32, 245–253
(October 2002); doi:10.1038/ng890
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letter
Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes
Shinji Kondo, Brian C. Schutte, Rebecca J. Richardson, Bryan C. Bjork, Alexandra S. Knight, Yoriko Watanabe, Emma Howard, Renata L.L. Ferreira de Lima, Sandra Daack-Hirsch, Achim Sander, Donna M. McDonald-McGinn, Elaine H. Zackai, Edward J. Lammer, Arthur S. Aylsworth, Holly H. Ardinger, Andrew C. Lidral, Barbara R. Pober, Lina Moreno, Mauricio Arcos-Burgos, Consuelo Valencia, Claude Houdayer, Michel Bahuau, Danilo Moretti-Ferreira, Antonio Richieri-Costa, Michael J. Dixon and Jeffrey C. Murray
Nature Genetics 32, 285–289
(October 2002); doi:10.1038/ng985
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news and views
The pit, the cleft and the web
Maximilian Muenke
Nature Genetics 32, 219–220
(October 2002); doi:10.1038/ng1002-219
| Full Text (HTML/PDF) |
news and views
Quorum sensing in Vibrio cholerae
Miguel Cámara, Andrea Hardman, Paul Williams and Debra Milton
Nature Genetics 32, 217–218
(October 2002); doi:10.1038/ng1002-217
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article
The sedative component of anesthesia is mediated by GABAA receptors in an endogenous sleep pathway
L E Nelson, T Z Guo, J Lu, C B Saper, N P Franks & M Maze
Nature Neuroscience 5, 979–984
(October 2002); doi:10.1038/nn913
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news and views
General anesthesia research: aroused from a deep sleep?
Neil L. Harrison
Nature Neuroscience 5, 928–929
(October 2002); doi:10.1038/nn1002-928
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review article
Discoveries, drugs and skeletal disorders
David Goltzman
Nature Reviews Drug Discovery 1, 784–796
(October 2002); doi:10.1038/nrd916
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review article
G-Protein-coupled receptor oligomerization and its potential for drug discovery
Susan R. George, Brian F. O'Dowd and Samuel P. Lee
Nature Reviews Drug Discovery 1, 808–820
(October 2002); doi:10.1038/nrd913
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article
Neurotrophin-evoked depolarization requires the sodium channel NaV1.9
Robert Blum, Karl W. Kafitz and Arthur Konnerth
Nature 419, 687–693
(17 October 2002); doi:10.1038/nature01085
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news and views
Neurobiology: Neurotrophin channels excitement
Yves-Alain Barde
Nature 419, 683–684
(17 October 2002); doi:10.1038/419683a
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letters to nature
Jasmonate and salicylate induce expression of herbivore cytochrome P450 genes
Xianchun Li, Mary A. Schuler and May R. Berenbaum
Nature 419, 712–715
(17 October 2002); doi:10.1038/nature01003
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letters to nature
A biological role for prokaryotic ClC chloride channels
Ramkumar Iyer, Tina M. Iverson, Alessio Accardi and Christopher Miller
Nature 419, 715–718
(17 October 2002); doi:10.1038/nature01000
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letters to nature
The DIX domain targets dishevelled to actin stress fibres and vesicular membranes
Daniel G. S. Capelluto, Tatiana G. Kutateladze, Raymond Habas, Carla V. Finkielstein, Xi He and Michael Overduin
Nature 419, 726–729
(17 October 2002); doi:10.1038/nature01056
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letters to nature
Myc suppression of the p21Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage
Joan Seoane, Hong-Van Le and Joan Massagué
Nature 419, 729–734
(17 October 2002); doi:10.1038/nature01119
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letters to nature
Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation
Veronika Groh, Jennifer Wu, Cassian Yee and Thomas Spies
Nature 419, 734–738
(17 October 2002); doi:10.1038/nature01112
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news and views
Immunology: Catch us if you can
Wayne M. Yokoyama
Nature 419, 679–680
(17 October 2002); doi:10.1038/419679a
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letters to nature
A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis
Lawryn H. Kasper, Fayçal Boussouar, Paul A. Ney, Carl W. Jackson, Jerold Rehg, Jan M. van Deursen and Paul K. Brindle
Nature 419, 738–743
(17 October 2002); doi:10.1038/nature01062
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article
Elimination of host cell PtdIns(4,5)P2 by bacterial SigD promotes membrane fission during invasion by Salmonella
Mauricio R. Terebiznik, Otilia V. Vieira, Sandra L. Marcus, Andrea Slade, Christopher M. Yip, William S. Trimble, Tobias Meyer, B. Brett Finlay and Sergio Grinstein
Nature Cell Biology 4, 766–773
(October 2002); doi:10.1038/ncb854
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brief communication
One-Eyed Pinhead and Spadetail are essential for heart and somite formation
Kevin J. P. Griffin and David Kimelman
Nature Cell Biology 4, 821–825
(October 2002); doi:10.1038/ncb862
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news and views
Bending the membrane
Barbara Marte
Nature Cell Biology 4, E229
(October 2002); doi:10.1038/ncb1002-e229
| Full Text (HTML/PDF) |
review article
How death shapes life during development
Eric H. Baehrecke
Nature Reviews Molecular Cell Biology 3, 779–787
(October 2002); doi:10.1038/nrm931
| Summary | Full Text (HTML / PDF) |
article
BAFF-induced NEMO-independent processing of NF-κB2 in maturing B cells
Estefania Claudio, Keith Brown, Sun Park, Hongshan Wang and Ulrich Siebenlist
Nature Immunology 3, 958–965
(October 2002); doi:10.1038/ni842
| Abstract | Full Text (HTML/PDF) |
news and views
Gatekeeper mechanisms for immature B cells
Xiao-Hong Sun and Paul W. Kincade
Nature Immunology 3, 898–899
(October 2002); doi:10.1038/ni1002-898
| Full Text (HTML/PDF) |
review article
Emerging roles of PPARs in inflammation and immunity
Raymond A. Daynes and Dallas C. Jones
Nature Reviews Immunology 2, 748–759
(October 2002); doi:10.1038/nri912
| Summary | Full Text (HTML / PDF) |
article
Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27Kip1 by PKB/Akt-mediated phosphorylation in breast cancer
Giuseppe Viglietto, Maria Letizia Motti, Paola Bruni, Rosa Marina Melillo, Amelia D'Alessio, Daniela Califano, Floriana Vinci, Gennaro Chiappetta, Philip Tsichlis, Alfonso Bellacosa, Alfredo Fusco and Massimo Santoro
Nature Medicine 8, 1136–1144
(October 2002); doi:10.1038/nm762
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article
PKB/Akt mediates cell-cycle progression by phosphorylation of p27Kip1 at threonine 157 and modulation of its cellular localization
Incheol Shin, F Michael Yakes, Federico Rojo, Nah-Young Shin, Andrei V. Bakin, Jose Baselga and Carlos L. Arteaga
Nature Medicine 8, 1145–1152
(October 2002); doi:10.1038/nm759
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article
PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest
Jiyong Liang, Judit Zubovitz, Teresa Petrocelli, Rouslan Kotchetkov, Michael K. Connor, Kathy Han, Jin-Hwa Lee, Sandra Ciarallo, Charles Catzavelos, Richard Beniston, Edmee Franssen and Joyce M. Slingerland
Nature Medicine 8, 1153–1160
(October 2002); doi:10.1038/nm761
| Abstract | Full Text (HTML/PDF) |
news and views
Breast cancer banishes p27 from nucleus
Stacy W. Blain and Joan Massagué
Nature Medicine 8, 1076–1078
(October 2002); doi:10.1038/nm1002-1076
| Full Text (HTML/PDF) |
review article
Transcription factors as targets for cancer therapy
James E. Darnell Jr,
Nature Reviews Cancer 2, 740–749
(October 2002); doi:10.1038/nrc906
| Summary | Full Text (HTML / PDF) |
article
Evidence for two apoptotic pathways in light-induced retinal degeneration
Wenshan Hao, Andreas Wenzel, Martin S. Obin, Ching-Kang Chen, Elliott Brill, Nataliia V. Krasnoperova, Pamela Eversole-Cire, Yelena Kleyner, Allen Taylor, Melvin I. Simon, Christian Grimm, Charlotte E. Remé and Janis Lem
Nature Genetics 32, 254–260
(October 2002); doi:10.1038/ng984
| Abstract | Full Text (HTML/PDF) |
news and views
Blinded by the light
Samuel G. Jacobson and Roderick R. McInnes
Nature Genetics 32, 215–216
(October 2002); doi:10.1038/ng1002-215
| Full Text (HTML/PDF) |
letter
Mutations in Rab3a alter circadian period and homeostatic response to sleep loss in the mouse
David Kapfhamer, Otto Valladares, Yi Sun, Patrick M. Nolan, John J. Rux, Steven E. Arnold, Sigrid C. Veasey and Maja Bucan
Nature Genetics 32, 290–295
(October 2002); doi:10.1038/ng991
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review article
Toll-like receptors as potential therapeutic targets for multiple diseases
Claudia Zuany-Amorim, John Hastewell and Christoph Walker
Nature Reviews Drug Discovery 1, 797–807
(October 2002); doi:10.1038/nrd914
| Summary | Full Text (HTML / PDF) |
letter
The Sak polo-box comprises a structural domain sufficient for mitotic subcellular localization
Genie C. Leung, John W. Hudson, Anna Kozarova, Alan Davidson, James W. Dennis and Frank Sicheri
Nature Structural Biology 9, 719–724
(October 2002); doi:10.1038/nsb848
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letters to nature
FGFR-related gene nou-darake restricts brain tissues to the head region of planarians
Francesc Cebrià, Chiyoko Kobayashi, Yoshihiko Umesono, Masumi Nakazawa, Katsuhiko Mineta, Kazuho Ikeo, Takashi Gojobori, Mari Itoh, Masanori Taira, Alejandro Sánchez Alvarado and Kiyokazu Agata
Nature 419, 620–624
(10 October 2002); doi:10.1038/nature01042
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letters to nature
Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2
Atsushi Kumanogoh, Satoko Marukawa, Kazuhiro Suzuki, Noriko Takegahara, Chie Watanabe, EweSeng Ch'ng, Isao Ishida, Harutoshi Fujimura, Saburo Sakoda, Kanji Yoshida and Hitoshi Kikutani
Nature 419, 629–633
(10 October 2002); doi:10.1038/nature01037
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letters to nature
Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome
Vanessa S. Marsden, Liam O'Connor, Lorraine A. O'Reilly, John Silke, Donald Metcalf, Paul G. Ekert, David C. S. Huang, Francesco Cecconi, Keisuke Kuida, Kevin J. Tomaselli, Sophie Roy, Don W. Nicholson, David L. Vaux, Philippe Bouillet, Jerry M. Adams and Andreas Strasser
Nature 419, 634–637
(10 October 2002); doi:10.1038/nature01101
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letters to nature
Reaction path of protein farnesyltransferase at atomic resolution
Stephen B. Long, Patrick J. Casey and Lorena S. Beese
Nature 419, 645–650
(10 October 2002); doi:10.1038/nature00986
| First Paragraph | Full Text (HTML / PDF) |
article
Redox regulatory and anti-apoptotic functions of thioredoxin depend on S-nitrosylation at cysteine 69
Judith Haendeler, Jörg Hoffmann, Verena Tischler, Bradford C. Berk, Andreas M. Zeiher and Stefanie Dimmeler
Nature Cell Biology 4, 743–749
(October 2002); doi:10.1038/ncb851
| Abstract | Full Text (HTML/PDF) |
article
Signal-dependent protection from apoptosis in mice expressing caspase-resistant Rb
B. Nelson Chau, Helena Lobo Borges, Tung-Ti Chen, Anja Masselli, Irina C. Hunton and Jean Y. J. Wang
Nature Cell Biology 4, 757–765
(October 2002); doi:10.1038/ncb853
| Abstract | Full Text (HTML/PDF) |
article
A GPI-linked isoform of the IgD receptor regulates resting B cell activation
Akanksha Chaturvedi, Zaved Siddiqui, Fahri Bayiroglu and Kanury V.S. Rao
Nature Immunology 3, 951–957
(October 2002); doi:10.1038/ni839
| Abstract | Full Text (HTML/PDF) |
article
Molecular anatomy of antigen-specific CD8+ T cell engagement and synapse formation in vivo
Dorian B. McGavern, Urs Christen and Michael B.A. Oldstone
Nature Immunology 3, 918–925
(October 2002); doi:10.1038/ni843
| First Paragraph | Full Text (HTML/PDF) |
news and views
Two faces of caspase-8
Bryan C. Barnhart and Marcus E. Peter
Nature Immunology 3, 896–898
(October 2002); doi:10.1038/ni1002-896
| Full Text (HTML/PDF) |
review article
NF-κB regulation in the immune system
Qiutang Li and Inder M. Verma
Nature Reviews Immunology 2, 725–734
(October 2002); doi:10.1038/nri910
| Summary | Full Text (HTML / PDF) |
review article
Functional significance of the perforin/granzyme cell death pathway
Joseph A. Trapani and Mark J. Smyth
Nature Reviews Immunology 2, 735–747
(October 2002); doi:10.1038/nri911
| Summary | Full Text (HTML / PDF) |
article
Multiple sclerosis: Re-expression of a developmental pathway that restricts oligodendrocyte maturation
Gareth R. John, Sai Latha Shankar, Bridget Shafit-Zagardo, Aldo Massimi, Sunhee C. Lee, Cedric S. Raine and Celia F. Brosnan
Nature Medicine 8, 1115–1121
(October 2002); doi:10.1038/nm781
| Abstract | Full Text (HTML/PDF) |
news and views
Myelin failure in multiple sclerosis: Breaking the spell of Notch
Reinhard Hohlfeld
Nature Medicine 8, 1075–1076
(October 2002); doi:10.1038/nm1002-1075
| Full Text (HTML/PDF) |
review article
Clinical translation of angiogenesis inhibitors
Robert Kerbel and Judah Folkman
Nature Reviews Cancer 2, 727–739
(October 2002); doi:10.1038/nrc905
| Summary | Full Text (HTML / PDF) |
letter
Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis
Juan A. Bernal, Rosa Luna, Águeda Espina, Icíar Lázaro, Francisco Ramos-Morales, Francisco Romero, Carmen Arias, Augusto Silva, María Tortolero and José A. Pintor-Toro
Nature Genetics 32, 306–311
(October 2002); doi:10.1038/ng997
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news and views
Securin a new role for itself
Anil K. Rustgi
Nature Genetics 32, 222–224
(October 2002); doi:10.1038/ng1002-222
| Full Text (HTML/PDF) |
letter
Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy
Johane Robitaille, Marcia L.E. MacDonald, Ajamete Kaykas, Laird C. Sheldahl, Jutta Zeisler, Marie-Pierre Dubé, Lin-Hua Zhang, Roshni R. Singaraja, Duane L. Guernsey, Binyou Zheng, Lee F. Siebert, Ann Hoskin-Mott, Michael T. Trese, Simon N. Pimstone, Barkur S. Shastry, Randall T. Moon, Michael R. Hayden, Y. Paul Goldberg and Mark E. Samuels
Nature Genetics 32, 326–330
(October 2002); doi:10.1038/ng957
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article
A transmembrane motif governs the surface trafficking of nicotinic acetylcholine receptors
Jun-Mei Wang, Lili Zhang, Yun Yao, Nitnara Viroonchatapan, Elizabeth Rothe and Zuo-Zhong Wang
Nature Neuroscience 5, 963–970
(October 2002); doi:10.1038/nn918
| Abstract | Full Text (HTML/PDF) |
review article
Structural biology of insulin and IGF1 receptors: implications for drug design
Pierre De Meyts and Jonathan Whittaker
Nature Reviews Drug Discovery 1, 769–783
(October 2002); doi:10.1038/nrd917
| Summary | Full Text (HTML / PDF) |
letter
Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor
Thomas G. Davies, Johanne Bentley, Christine E. Arris, F. Thomas Boyle, Nicola J. Curtin, Jane A. Endicott, Ashleigh E. Gibson, Bernard T. Golding, Roger J. Griffin, Ian R. Hardcastle, Philip Jewsbury, Louise N. Johnson, Veronique Mesguiche, David R. Newell, Martin E.M. Noble, Julie A. Tucker, Lan Wang and Hayley J. Whitfield
Nature Structural Biology 9, 745–749
(October 2002); doi:10.1038/nsb842
| First Paragraph | Full Text (HTML/PDF) |
original paper
Both the Smad and p38 MAPK pathways play a crucial role in Runx2 expression following induction by transforming growth factor-β and bone morphogenetic protein
Kyeong-Sook Lee, Seung-Hyun Hong & Suk-Chul Bae
Oncogene 21, 7156–7163
(17 October 2002); doi:10.1038/sj.onc.1205937
| First Paragraph |
letters to nature
Dendrite growth increased by visual activity requires NMDA receptor and Rho GTPases
Wun Chey Sin, Kurt Haas, Edward S. Ruthazer and Hollis T. Cline
Nature 419, 475–480
(03 October 2002); doi:10.1038/nature00987
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum
Thomas Serwold, Federico Gonzalez, Jennifer Kim, Richard Jacob and Nilabh Shastri
Nature 419, 480–483
(03 October 2002); doi:10.1038/nature01074
| First Paragraph | Full Text (HTML / PDF) |
news and views
Immunology: Survival of the fitters
Hans-Georg Rammensee
Nature 419, 443–445
(03 October 2002); doi:10.1038/419443a
| Full Text (HTML / PDF) |
letters to nature
Molecular basis of transmembrane signalling by sensory rhodopsin II-transducer complex
Valentin I. Gordeliy, Jörg Labahn, Rouslan Moukhametzianov, Rouslan Efremov, Joachim Granzin, Ramona Schlesinger, Georg Büldt, Tudor Savopol, Axel J. Scheidig, Johann P. Klare and Martin Engelhard
Nature 419, 484–487
(03 October 2002); doi:10.1038/nature01109
| First Paragraph | Full Text (HTML / PDF) |
article
Activation of the repulsive receptor Roundabout inhibits N-cadherin-mediated cell adhesion
Jinseol Rhee, Najmus S. Mahfooz, Carlos Arregui, Jack Lilien, Janne Balsamo and Mark F.A. VanBerkum
Nature Cell Biology 4, 798–805
(October 2002); doi:10.1038/ncb858
| Abstract | Full Text (HTML/PDF) |
news and views
Robo is Abl to block N-Cadherin function
Mark M. Emerson and David Van Vactor
Nature Cell Biology 4, E227
(October 2002); doi:10.1038/ncb1002-e227
| Full Text (HTML/PDF) |
brief communication
Astral microtubules monitor metaphase spindle alignment in fission yeast
Snezhana Oliferenko and Mohan K. Balasubramanian
Nature Cell Biology 4, 816–820
(October 2002); doi:10.1038/ncb861
| First Paragraph | Full Text (HTML/PDF) |
news and views
First things first: spindle orientation and mitotic progression
Dannel McCollum
Nature Cell Biology 4, E225
(October 2002); doi:10.1038/ncb1002-e225
| Full Text (HTML/PDF) |
review article
The spindle checkpoint: structural insights into dynamic signalling
Andrea Musacchio and Kevin G. Hardwick
Nature Reviews Molecular Cell Biology 3, 731–741
(October 2002); doi:10.1038/nrm929
| Summary | Full Text (HTML / PDF) |
review article
The Yersinia Ysc-Yop 'Type III' weaponry
Guy R. Cornelis
Nature Reviews Molecular Cell Biology 3, 742–754
(October 2002); doi:10.1038/nrm932
| Summary | Full Text (HTML / PDF) |
article
Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis
Jeffrey C. Rathmell, Tullia Lindsten, Wei-Xing Zong, Ryan M. Cinalli and Craig B. Thompson
Nature Immunology 3, 932–939
(October 2002); doi:10.1038/ni834
| Abstract | Full Text (HTML/PDF) |
news and views
Bax and Bak: back-bone of T cell death
Philippe Bouillet and Andreas Strasser
Nature Immunology 3, 893–894
(October 2002); doi:10.1038/ni1002-893
| Full Text (HTML/PDF) |
review article
Regulation of mast-cell and basophil function and survival by IgE
Toshiaki Kawakami and Stephen J. Galli
Nature Reviews Immunology 2, 773–786
(October 2002); doi:10.1038/nri914
| Summary | Full Text (HTML / PDF) |
article
CDK4 coexpression with Ras generates malignant human epidermal tumorigenesis
Mirella Lazarov, Yoshiaki Kubo, Ti Cai, Maya Dajee, Masahito Tarutani, Qun Lin, Min Fang, Shiying Tao, Cheryl L. Green and Paul A. Khavari
Nature Medicine 8, 1105–1114
(October 2002); doi:10.1038/nm779
| Abstract | Full Text (HTML/PDF) |
article
Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice
Niall C. Tebbutt, Andrew S. Giraud, Melissa Inglese, Brendan Jenkins, Paul Waring, Fiona J. Clay, Sina Malki, Barbara M. Alderman, Dianne Grail, Frédéric Hollande, Joan K. Heath and Matthias Ernst
Nature Medicine 8, 1089–1097
(October 2002); doi:10.1038/nm763
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news and views
Inflammation intersection: gp130 balances gut irritation and stomach cancer
Timothy C. Wang and James R. Goldenring
Nature Medicine 8, 1080–1082
(October 2002); doi:10.1038/nm1002-1080
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perspectives
Timeline: VEGF and the quest for tumour angiogenesis factors
Napoleone Ferrara
Nature Reviews Cancer 2, 795–803
(October 2002); doi:10.1038/nrc909
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article
Genome-wide association study and mouse model identify interaction between RET and EDNRB pathways in Hirschsprung disease
Minerva M. Carrasquillo, Andrew S. McCallion, Erik G. Puffenberger, Carl S. Kashuk, Nassim Nouri and Aravinda Chakravarti
Nature Genetics 32, 237–244
(October 2002); doi:10.1038/ng998
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article
Reelin is a detachment signal in tangential chain-migration during postnatal neurogenesis
Iris Hack, Mircea Bancila, Karine Loulier, Patrick Carroll and Harold Cremer
Nature Neuroscience 5, 939–945
(October 2002); doi:10.1038/nn923
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review article
Protein palmitoylation: a regulator of neuronal development and function
Alaa El-Din El-Husseini and David S. Bredt
Nature Reviews Neuroscience 3, 791–802
(October 2002); doi:10.1038/nrn940
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original paper
Caspase-6 is the direct activator of caspase-8 in the cytochrome c-induced apoptosis pathway: absolute requirement for removal of caspase-6 prodomain
V Cowling & J Downward
Cell Death and Differentiation 9, 1046–1056
(October 2002); doi:10.1038/sj.cdd.4401065
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