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Research library: browse by date

December 2002

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The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.

Click here for free access to the 'Featured Articles' section, with new articles every week.

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letters to nature
A role for casein kinase 2α in the Drosophila circadian clock
Jui-Ming Lin, Valerie L. Kilman, Kevin Keegan, Brie Paddock, Myai Emery-Le, Michael Rosbash and Ravi Allada
Nature 420, 816–820
(19 December 2002); doi:10.1038/nature01235
| First Paragraph | Full Text (HTML / PDF) |

letters to nature
Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c
Avirup Bose, Adilson Guilherme, Stacey I. Robida, Sarah M. C. Nicoloro, Qiong L. Zhou, Zhen Y. Jiang, Darcy P. Pomerleau and Michael P. Czech
Nature 420, 821–824
(19 December 2002); doi:10.1038/nature01246
| First Paragraph | Full Text (HTML / PDF) |

letters to nature
Helper T cells regulate type-2 innate immunity in vivo
Kanade Shinkai, Markus Mohrs and Richard M. Locksley
Nature 420, 825–829
(19 December 2002); doi:10.1038/nature01202
| First Paragraph | Full Text (HTML / PDF) |

letters to nature
Role for a Drosophila Myb-containing protein complex in site-specific DNA replication
Eileen L. Beall, J. Robert Manak, Sharleen Zhou, Maren Bell, Joseph S. Lipsick and Michael R. Botchan
Nature 420, 833–837
(19 December 2002); doi:10.1038/nature01228
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article
Planar polarity and actin dynamics in the epidermis of Drosophila
Julia A. Kaltschmidt, Nicola Lawrence, Véronique Morel, Tina Balayo, Beatriz García Fernández, Anne Pelissier, Antonio Jacinto and Alfonso Martinez Arias
Nature Cell Biology 4, 937–944
(December 2002); doi:10.1038/ncb882
| Abstract | Full Text (HTML/PDF) |

brief communication
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1
Oscar Fernandez-Capetillo, Hua-Tang Chen, Arkady Celeste, Irene Ward, Peter J. Romanienko, Julio C. Morales, Kazuhito Naka, Zhenfang Xia, R. Daniel Camerini-Otero, Noboru Motoyama, Phillip B. Carpenter, William M. Bonner, Junjie Chen and André Nussenzweig
Nature Cell Biology 4, 993–997
(December 2002); doi:10.1038/ncb884
| First Paragraph | Full Text (HTML/PDF) |

brief communication
53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer
Richard A. DiTullio, Jr Tamara A. Mochan, Monica Venere, Jirina Bartkova, Maxwell Sehested, Jiri Bartek and Thanos D. Halazonetis
Nature Cell Biology 4, 998–1002
(December 2002); doi:10.1038/ncb892
| First Paragraph | Full Text (HTML/PDF) |

news and views
Checkpoint signalling: focusing on 53BP1
Robert T. Abraham
Nature Cell Biology 4, E277
(December 2002); doi:10.1038/ncb1202-e277
| Full Text (HTML/PDF) |

meeting report
Cell motility: insights from the backstage
Maryse Bailly and John Condeelis
Nature Cell Biology 4, E292
(December 2002); doi:10.1038/ncb1202-e292
| Full Text (HTML/PDF) |

review article
Sorting out the cellular functions of sorting nexins
Carolyn A. Worby and Jack E. Dixon
Nature Reviews Molecular Cell Biology 3, 919–931
(December 2002); doi:10.1038/nrm974
| Summary | Full Text (HTML / PDF) |

perspectives
Opinion: Epsins: adaptors in endocytosis?
Beverly Wendland
Nature Reviews Molecular Cell Biology 3, 971–977
(December 2002); doi:10.1038/nrm970
| Summary | Full Text (HTML / PDF) |

article
Indirect activation of naïve CD4+ T cells by dendritic cell-derived exosomes
Clotilde Théry, Livine Duban, Elodie Segura, Philippe Véron, Olivier Lantz and Sebastian Amigorena
Nature Immunology 3, 1156–1162
(December 2002); doi:10.1038/ni854
| Abstract | Full Text (HTML/PDF) |

article
An IFN-γ-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides
Tomo Saric, Shih-Chung Chang, Akira Hattori, Ian A. York, Shirley Markant, Kenneth L. Rock, Masafumi Tsujimoto and Alfred L. Goldberg
Nature Immunology 3, 1169–1176
(December 2002); doi:10.1038/ni859
| Abstract | Full Text (HTML/PDF) |

article
The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues
Ian A. York, Shih-Chung Chang, Tomo Saric, Jennifer A. Keys, Janice M. Favreau, Alfred L. Goldberg and Kenneth L. Rock
Nature Immunology 3, 1177–1184
(December 2002); doi:10.1038/ni860
| Abstract | Full Text (HTML/PDF) |

news and views
The final cut: how ERAP1 trims MHC ligands to size
Kirsten Falk and Olaf Rötzschke
Nature Immunology 3, 1121–1122
(December 2002); doi:10.1038/ni1202-1121
| Full Text (HTML/PDF) |

article
Defective CCR7 expression on dendritic cells contributes to the development of visceral leishmaniasis
Manabu Ato, Simona Stäger, Christian R. Engwerda and Paul M. Kaye
Nature Immunology 3, 1185–1191
(December 2002); doi:10.1038/ni861
| Abstract | Full Text (HTML/PDF) |

article
c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation
Mayumi Naramura, Ihn-Kyung Jang, Hemanta Kole, Fang Huang, Diana Haines and Hua Gu
Nature Immunology 3, 1192–1199
(December 2002); doi:10.1038/ni855
| Abstract | Full Text (HTML/PDF) |

review article
Hydrogen peroxide as second messenger in lymphocyte activation
Michael Reth
Nature Immunology 3, 1129–1134
(December 2002); doi:10.1038/ni1202-1129
| Abstract | Full Text (HTML/PDF) |

review article
The lineage decisions of helper T cells
Kenneth M. Murphy and Steven L. Reiner
Nature Reviews Immunology 2, 933–944
(December 2002); doi:10.1038/nri954
| Summary | Full Text (HTML / PDF) |

review article
Natural killer cells and dendritic cells: rendezvous in abused tissues
Alessandro Moretta
Nature Reviews Immunology 2, 957–965
(December 2002); doi:10.1038/nri956
| Summary | Full Text (HTML / PDF) |

article
Serum insulin-like growth factor I regulates brain amyloid-β levels
E. Carro, J.L. Trejo, T. Gomez-Isla, D. LeRoith and I. Torres-Aleman
Nature Medicine 8, 1390–1397
(December 2002); doi:10.1038/nm793
| Abstract | Full Text (HTML/PDF) |

article
Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease
Yonglian Sun, Helen M. Chen, Sumit K. Subudhi, Jonathan Chen, Rima Koka, Lieping Chen and Yang-Xin Fu
Nature Medicine 8, 1405–1413
(December 2002); doi:10.1038/nm796
| Abstract | Full Text (HTML/PDF) |

news and views
Immunotherapy tackles lupus
Gary M. Kammer
Nature Medicine 8, 1356–1358
(December 2002); doi:10.1038/nm1202-1356
| Full Text (HTML/PDF) |

article
β cells are responsible for CXCR3-mediated T-cell infiltration in insulitis
Simona Frigerio, Tobias Junt, Bao Lu, Craig Gerard, Urs Zumsteg, Georg A. Holländer and Luca Piali
Nature Medicine 8, 1414–1420
(December 2002); doi:10.1038/nm792
| Abstract | Full Text (HTML/PDF) |

article
The neuropeptides GnRH-II and GnRH-I are produced by human T cells and trigger laminin receptor gene expression, adhesion, chemotaxis and homing to specific organs
Alon Chen, Yonatan Ganor, Shai Rahimipour, Nurit Ben-Aroya, Yitzhak Koch and Mia Levite
Nature Medicine 8, 1421–1426
(December 2002); doi:10.1038/nm801
| Abstract | Full Text (HTML/PDF) |

article
T cells require TRAIL for optimal graft-versus-tumor activity
Cornelius Schmaltz, Onder Alpdogan, Barry J. Kappel, Stephanie J. Muriglan, Jimmy A. Rotolo, Jennifer Ongchin, Lucy M. Willis, Andrew S. Greenberg, Jeffrey M. Eng, James M. Crawford, George F. Murphy, Hideo Yagita, Henning Walczak, Jacques J. Peschon and Marcel R.M. van den Brink
Nature Medicine 8, 1433–1437
(December 2002); doi:10.1038/nm797
| Abstract | Full Text (HTML/PDF) |

news and views
Skin antibiotics get in the loop
Elizabeth Kopp and Ruslan Medzhitov
Nature Medicine 8, 1359–1360
(December 2002); doi:10.1038/nm1202-1359
| Full Text (HTML/PDF) |

news and views
Crowd control in the crypt
Catherine Booth, Gerard Brady and Christopher S. Potten
Nature Medicine 8, 1360–1361
(December 2002); doi:10.1038/nm1202-1360
| Full Text (HTML/PDF) |

review article
The many faces of tumor necrosis factor in stroke
John M. Hallenbeck
Nature Medicine 8, 1363–1368
(December 2002); doi:10.1038/nm1202-1363
| Full Text (HTML/PDF) |

review article
Pancreatic cancer biology and genetics
Nabeel Bardeesy and Ronald A. DePinho
Nature Reviews Cancer 2, 897–909
(December 2002); doi:10.1038/nrc949
| Summary | Full Text (HTML / PDF) |

review article
Molecular mechanisms of novel therapeutic approaches for multiple myeloma
Teru Hideshima and Kenneth C. Anderson
Nature Reviews Cancer 2, 927–937
(December 2002); doi:10.1038/nrc952
| Summary | Full Text (HTML / PDF) |

article
Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice
Jun Tan, Terrence Town, Fiona Crawford, Takashi Mori, Anthony DelleDonne, Robert Crescentini, Demian Obregon, Richard A. Flavell and Michael J. Mullan
Nature Neuroscience 5, 1288–1293
(December 2002); doi:10.1038/nn968
| Abstract | Full Text (HTML/PDF) |

review article
Asymmetric segregation of Numb: a mechanism for neural specification from Drosophila to mammals
Michel Cayouette and Martin Raff
Nature Neuroscience 5, 1265–1269
(December 2002); doi:10.1038/nn1202-1265
| Abstract | Full Text (HTML/PDF) |

review article
Parsing the prosencephalon
Murielle Rallu, Joshua G. Corbin and Gord Fishell
Nature Reviews Neuroscience 3, 943–951
(December 2002); doi:10.1038/nrn989
| Summary | Full Text (HTML / PDF) |

review article
Role of neurotrophins in central synapse formation and stabilization
Carlos Vicario-Abejón, David Owens, Ronald McKay and Menahem Segal
Nature Reviews Neuroscience 3, 965–974
(December 2002); doi:10.1038/nrn988
| Summary | Full Text (HTML / PDF) |

letter
Structural characterization of a proline-driven conformational switch within the Itk SH2 domain
Robert J. Mallis, Kristine N. Brazin, D. Bruce Fulton and Amy H. Andreotti
Nature Structural Biology 9, 900–905
(December 2002); doi:10.1038/nsb864
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review article
New therapeutics that antagonize endothelin: promises and frustrations
Giuseppe Remuzzi , Norberto Perico and Ariela Benigni
Nature Reviews Drug Discovery 1, 986–1001
(December 2002); doi:10.1038/nrd962
| Summary | Full Text (HTML / PDF) |

article
Structural basis of BMP signalling inhibition by the cystine knot protein Noggin
Jay Groppe, Jason Greenwald, Ezra Wiater, Joaquin Rodriguez-Leon, Aris N. Economides, Witek Kwiatkowski, Markus Affolter, Wylie W. Vale, Juan Carlos Izpisua Belmonte and Senyon Choe
Nature 420, 636–642
(12 December 2002); doi:10.1038/nature01245
| Summary | Full Text (HTML / PDF) |

news and views
On the wings of inhibition
Jeffrey L. Wrana
Growth factors regulate cell behaviour, and are kept in check by inhibitors. The structure of a complex of two such proteins shows that they form back-to-back butterflies, with the inhibitor's wings stretching to embrace its partner.
Nature 420, 613–614
(12 December 2002); doi:10.1038/420613a
| Full Text (HTML / PDF) |

letters to nature
Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime
Hyuk Wan Ko, Jin Jiang and Isaac Edery
Nature AOP published online 20 November 2002; doi:10.1038/nature01272
| First Paragraph | Full Text (HTML / PDF) |

letters to nature
Endocytosis-mediated downregulation of LIN-12/Notch upon Ras activation in Caenorhabditis elegans
Daniel D. Shaye and Iva Greenwald
Nature 420, 686–690
(12 December 2002); doi:10.1038/nature01234
| First Paragraph | Full Text (HTML / PDF) |

letters to nature
Signal-dependent regulation of splicing via phosphorylation of Sam68
Nathalie Matter, Peter Herrlich and Harald König
Nature 420, 691–695
(12 December 2002); doi:10.1038/nature01153
| First Paragraph | Full Text (HTML / PDF) |

letters to nature
Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand
Ivan Bosanac, Jean-René Alattia, Tapas K. Mal, Jenny Chan, Susanna Talarico, Frances K. Tong, Kit I. Tong, Fumio Yoshikawa, Teiichi Furuichi, Miwako Iwai, Takayuki Michikawa, Katsuhiko Mikoshiba and Mitsuhiko Ikura
Nature AOP published online 17 November 2002; doi:10.1038/nature01268
| First Paragraph | Full Text (HTML / PDF) |

review article
Rho GTPases in cell biology
Sandrine Etienne-Manneville and Alan Hall
Nature 420, 629–635
(12 December 2002); doi:10.1038/nature01148
| Summary | Full Text (HTML / PDF) |

article
ARF6-GTP recruits Nm23-H1 to facilitate dynamin-mediated endocytosis during adherens junctions disassembly
Felipe Palacios, Jill K. Schweitzer, Rita L. Boshans and Crislyn D'Souza-Schorey
Nature Cell Biology 4, 929–936
(December 2002); doi:10.1038/ncb881
| Abstract | Full Text (HTML/PDF) |

brief communication
Activin/TGF-β induce apoptosis through Smad-dependent expression of the lipid phosphatase SHIP
Hector Valderrama-Carvajal, Eftihia Cocolakis, Annie Lacerte, Eun-Hye Lee, Gerald Krystal, Suhad Ali and Jean-Jacques Lebrun
Nature Cell Biology 4, 963–969
(December 2002); doi:10.1038/ncb885
| First Paragraph | Full Text (HTML/PDF) |

brief communication
Extraembryonic proteases regulate Nodal signalling during gastrulation
Séverine Beck, J. Ann Le Good, Marcela Guzman, Nadav Ben Haim, Karine Roy, Friedrich Beermann and Daniel B. Constam
Nature Cell Biology 4, 981–985
(December 2002); doi:10.1038/ncb890
| First Paragraph | Full Text (HTML/PDF) |

news and views
PLC-γ: an old player has a new role
James W. Putney Jr
Nature Cell Biology 4, E280
(December 2002); doi:10.1038/ncb1202-e280
| | Full Text (HTML/PDF) |

meeting report
Ubiquitin branches out
Erica S. Johnson
Nature Cell Biology 4, E295
(December 2002); doi:10.1038/ncb1202-e295
| Full Text (HTML/PDF) |

review article
Immunoglobulin transport across polarized epithelial cells
Raul Rojas and Gerard Apodaca
Nature Reviews Molecular Cell Biology 3, 944–956
(December 2002); doi:10.1038/nrm972
| Summary | Full Text (HTML / PDF) |

review article
uPAR: a versatile signalling orchestrator
Francesco Blasi and Peter Carmeliet
Nature Reviews Molecular Cell Biology 3, 932–943
(December 2002); doi:10.1038/nrm977
| Summary | Full Text (HTML / PDF) |

article
Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D
Andreas Diefenbach, Elena Tomasello, Mathias Lucas, Amanda M. Jamieson, Jennifer K. Hsia, Eric Vivier and David H. Raulet
Nature Immunology 3, 1142–1149
(December 2002); doi:10.1038/ni858
| Abstract | Full Text (HTML/PDF) |

article
NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation
Susan Gilfillan, Emily L. Ho, Marina Cella, Wayne M. Yokoyama and Marco Colonna
Nature Immunology 3, 1150–1155
(December 2002); doi:10.1038/ni857
| Abstract | Full Text (HTML/PDF) |

news and views
Versatile signaling through NKG2D
Eric O. Long
Nature Immunology 3, 1119–1120
(December 2002); doi:10.1038/ni1202-1119
| | Full Text (HTML/PDF) |

review article
Regulation of B-cell fate by antigen-receptor signals
Hiroaki Niiro and Edward A. Clark
Nature Reviews Immunology 2, 945–956
(December 2002); doi:10.1038/nri955
| Summary | Full Text (HTML / PDF) |

review article
A blast from the past: clearance of apoptotic cells regulates immune responses
John Savill, Ian Dransfield, Chris Gregory and Chris Haslett
Nature Reviews Immunology 2, 965–975
(December 2002); doi:10.1038/nri957
| Summary | Full Text (HTML / PDF) |

article
Hypothalamic insulin signaling is required for inhibition of glucose production
Silvana Obici, Bei B. Zhang, George Karkanias and Luciano Rossetti
Nature Medicine 8, 1376–1382
(December 2002); doi:10.1038/nm798
| Abstract | Full Text (HTML/PDF) |

article
A DNA vaccine against VEGF receptor 2 prevents effective angiogenesis and inhibits tumor growth
Andreas G. Niethammer, Rong Xiang, Jürgen C. Becker, Harald Wodrich, Ursula Pertl, Gabriele Karsten, Brian P. Eliceiri and Ralph A. Reisfeld
Nature Medicine 8, 1369–1375
(December 2002); doi:10.1038/nm794
| Abstract | Full Text (HTML/PDF) |

news and views
Vessel maneuvers: Vaccine targets tumor vasculature
Michael S. O'Reilly
Nature Medicine 8, 1352–1353
(December 2002); doi:10.1038/nm1202-1352
| | Full Text (HTML/PDF) |

review article
Bloodborne biomolecular markers in prostate cancer development and progression
Robert A. Bok and Eric J. Small
Nature Reviews Cancer 2, 918–926
(December 2002); doi:10.1038/nrc951
| Summary | Full Text (HTML / PDF) |

review article
The retinoblastoma tumour suppressor in development and cancer
Marie Classon and Ed Harlow
Nature Reviews Cancer 2, 910–917
(December 2002); doi:10.1038/nrc950
| Summary | Full Text (HTML / PDF) |

article
Bi-directional signaling by Semaphorin 1a during central synapse formation in Drosophila
Tanja A. Godenschwege, Hailan Hu, Xiaoliang Shan-Crofts, Corey S. Goodman and Rodney K. Murphey
Nature Neuroscience 5, 1294–1301
(December 2002); doi:10.1038/nn976
| Abstract | Full Text (HTML/PDF) |

article
A p75NTR and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein
Scott T. Wong, John R. Henley, Kevin C. Kanning, Kuo-hua Huang, Mark Bothwell and Mu-ming Poo
Nature Neuroscience 5, 1302–1308
(December 2002); doi:10.1038/nn975
| Abstract | Full Text (HTML/PDF) |

review article
Pathogenesis of parkinson's disease: dopamine, vesicles and α-synuclein
Julie Lotharius and Patrik Brundin
Nature Reviews Neuroscience 3, 932–942
(December 2002); doi:10.1038/nrn983
| Summary | Full Text (HTML / PDF) |

letter
Crystal structure of an activated Akt/Protein Kinase B ternary complex with GSK3-peptide and AMP-PNP
Jing Yang, Peter Cron, Valerie M. Good, Vivienne Thompson, Brian A. Hemmings and David Barford
Nature Structural Biology 9, 940–944
(December 2002); doi:10.1038/nsb870
| First Paragraph | Full Text (HTML/PDF) |

review article
Dual-specificity phosphatases as targets for antineoplastic agents
Michael A. Lyon, Alexander P. Ducruet, Peter Wipf and John S. Lazo
Nature Reviews Drug Discovery 1, 961–976
(December 2002); doi:10.1038/nrd963
| Summary | Full Text (HTML / PDF) |

letters to nature
Calcium activation of BKCa potassium channels lacking the calcium bowl and RCK domains
Rebecca Piskorowski and Richard W. Aldrich
Nature 420, 499–502
(05 December 2002); doi:10.1038/nature01199
| First Paragraph | Full Text (HTML / PDF) |

letters to nature
CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity
Yasmine Belkaid, Ciriaco A. Piccirillo, Susana Mendez, Ethan M. Shevach and David L. Sacks
Nature 420, 502–507
(05 December 2002); doi:10.1038/nature01152
| First Paragraph | Full Text (HTML / PDF) |

brief communication
The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling
Scott H. Soderling, Kathleen L. Binns, Gary A. Wayman, Stephen M. Davee, Siew Hwa Ong, Tony Pawson and John D. Scott
Nature Cell Biology 4, 970–975
(December 2002); doi:10.1038/ncb886
| First Paragraph | Full Text (HTML/PDF) |

brief communication
Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex
Theodoros Matanis, Anna Akhmanova, Phebe Wulf, Elaine Del Nery, Thomas Weide, Tatiana Stepanova, Niels Galjart, Frank Grosveld, Bruno Goud, Chris I. De Zeeuw, Angelika Barnekow and Casper C. Hoogenraad
Nature Cell Biology 4, 986–992
(December 2002); doi:10.1038/ncb891
| First Paragraph | Full Text (HTML/PDF) |

brief communication
Pointed and Tramtrack69 establish an EGFR-dependent transcriptional switch to regulate mitosis
Antonio Baonza, Christopher M. Murawsky, Andrew A. Travers and Matthew Freeman
Nature Cell Biology 4, 976–980
(December 2002); doi:10.1038/ncb887
| First Paragraph | Full Text (HTML/PDF) |

news and views
Tumour suppression: something for nothing?
Elisa de Stanchina and Scott W. Lowe
Nature Cell Biology 4, E275
(December 2002); doi:10.1038/ncb1202-e275
| Full Text (HTML/PDF) |

review article
Receptor Downregulation and Multivesicular-Body Sorting
David J. Katzmann, Greg Odorizzi and Scott D. Emr
Nature Reviews Molecular Cell Biology 3, 893–905
(December 2002); doi:10.1038/nrm973
| Summary | Full Text (HTML / PDF) |

perspectives
Opinion: How do microtubules guide migrating cells?
J. Victor Small, Benjamin Geiger, Irina Kaverina and Alexander Bershadsky
Nature Reviews Molecular Cell Biology 3, 957–964
(December 2002); doi:10.1038/nrm971
| Summary | Full Text (HTML / PDF) |

article
CD1-dependent dendritic cell instruction
Michael S. Vincent, David S. Leslie, Jenny E. Gumperz, Xiaowei Xiong, Ethan P. Grant and Michael B. Brenner
Nature Immunology 3, 1163–1168
(December 2002); doi:10.1038/ni851
| Abstract | Full Text (HTML/PDF) |

news and views
Do T cell receptors do it alone?
P.Anton van der Merwe
Nature Immunology 3, 1122–1123
(December 2002); doi:10.1038/ni1202-1122
| Full Text (HTML/PDF) |

review article
Lymphoid Malignancies: the dark side of B-cell differentiation
A. L. Shaffer, Andreas Rosenwald and Louis M. Staudt
Nature Reviews Immunology 2, 920–933
(December 2002); doi:10.1038/nri953
| Summary | Full Text (HTML / PDF) |

perspectives
Opinion: Progressive differentiation and selection of the fittest in the immune response
Antonio Lanzavecchia and Federica Sallusto
Nature Reviews Immunology 2, 982–987
(December 2002); doi:10.1038/nri959
| Summary | Full Text (HTML / PDF) |

article
Induction of angiogenesis in a mouse model using engineered transcription factors
Edward J. Rebar, Yan Huang, Reed Hickey, Anjali K. Nath, David Meoli, Sameer Nath, Bingliang Chen, Lei Xu, Yuxin Liang, Andrew C. Jamieson, Lei Zhang, S Kaye Spratt, Casey C. Case, Alan Wolffe and Frank J. Giordano
Nature Medicine 8, 1427–1432
(December 2002); doi:10.1038/nm795
| Abstract | Full Text (HTML/PDF) |

news and views
Vessel maneuvers: Zinc fingers promote angiogenesis
Renata Pasqualini, Carlos F. Barbas and III Wadih Arap
Nature Medicine 8, 1353–1354
(December 2002); doi:10.1038/nm1202-1353
| Full Text (HTML/PDF) |

review article
Oncolytic viruses
E. Antonio Chiocca
Nature Reviews Cancer 2, 938–950
(December 2002); doi:10.1038/nrc948
| Summary | Full Text (HTML / PDF) |

perspectives
Timeline: Polyoma virus middle T antigen and its role in identifying cancer-related molecules
Stephen M. Dilworth
Nature Reviews Cancer 2, 951–956
(December 2002); doi:10.1038/nrc946
| Summary | Full Text (HTML / PDF) |

brief communication
Neural plasticity and addiction: PI3-kinase and cocaine behavioral sensitization
Emanuela Izzo, Rémi Martin-Fardon, George F. Koob, Friedbert Weiss and Pietro Paolo Sanna
Nature Neuroscience 5, 1263–1264
(December 2002); doi:10.1038/nn977
| First Paragraph | Full Text (HTML/PDF) |

article
Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways
Rie Suzuki, Sara Morcuende, Mark Webber, Stephen P. Hunt and Anthony H. Dickenson
Nature Neuroscience 5, 1319–1326
(December 2002); doi:10.1038/nn966
| Abstract | Full Text (HTML/PDF) |

review article
Regulation of transcription factors by neuronal activity
Anne E. West, Eric C. Griffith and Michael E. Greenberg
Nature Reviews Neuroscience 3, 921–931
(December 2002); doi:10.1038/nrn987
| Summary | Full Text (HTML / PDF) |

research article
Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation
Jerôme Aubert, Hannah Dunstan, Ian Chambers and Austin Smith
Nature Biotechnology 20, 1240–1245
(December 2002); doi:10.1038/nbt763
| Abstract | Full Text (HTML/PDF) |

news and views
Signposts on the neural path
David Gottlieb
Nature Biotechnology 20, 1208–1210
(December 2002); doi:10.1038/nbt1202-1208
| Full Text (HTML/PDF) |

review article
Blocking NO synthesis: how, where and why?
Patrick Vallance and James Leiper
Nature Reviews Drug Discovery 1, 939–950
(December 2002); doi:10.1038/nrd960
| Summary | Full Text (HTML / PDF) |

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