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The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.
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article
Three-dimensional structural dynamics of myosin V by single-molecule fluorescence polarization
Joseph N. Forkey, Margot E. Quinlan, M. Alexander Shaw, John E. T. Corrie and Yale E. Goldman
Nature 422, 399–404
(27 March 2003); doi:10.1038/nature01529
| Summary | Full Text (HTML / PDF) |
letters to nature
The role of presenilin cofactors in the γ-secretase complex
Nobumasa Takasugi, Taisuke Tomita, Ikuo Hayashi, Makiko Tsuruoka, Manabu Niimura, Yasuko Takahashi, Gopal Thinakaran and Takeshi Iwatsubo
Nature 422, 438–441
(27 March 2003); doi:10.1038/nature01506
| First Paragraph | Full Text (HTML / PDF) |
news and views
Neurobiology: Ballads of a protein quartet
Mark P. Mattson
Nature 422, 385–387
(27 March 2003); doi:10.1038/422385a
| Full Text (HTML / PDF) |
letters to nature
Reactive oxygen species produced by NADPH oxidase regulate plant cell growth
Julia Foreman, Vadim Demidchik, John H. F. Bothwell, Panagiota Mylona, Henk Miedema, Miguel Angel Torres, Paul Linstead, Silvia Costa, Colin Brownlee, Jonathan D. G. Jones, Julia M. Davies and Liam Dolan
Nature 422, 442–446
(27 March 2003); doi:10.1038/nature01485
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Hidden complexity in the mechanical properties of titin
Philip M. Williams, Susan B. Fowler, Robert B. Best, José Luis Toca-Herrera, Kathryn A. Scott, Annette Steward and Jane Clarke
Nature 422, 446–449
(27 March 2003); doi:10.1038/nature01517
| First Paragraph | Full Text (HTML / PDF) |
letter
A non-proteolytic function of separase links the onset of anaphase to mitotic exit
Matt Sullivan and Frank Uhlmann
Nature Cell Biology 5, 249–254
(March 2003); doi:10.1038/ncb940
| Abstract | Full Text (HTML/PDF) |
news and views
Multitasking at mitotic exit
Karen E. Ross and Orna Cohen-Fix
Nature Cell Biology 5, 188–190
(March 2003); doi:10.1038/ncb0303-188
| Full Text (HTML/PDF) |
letter
Cytokines suppress adipogenesis and PPAR-γ function through the TAK1/TAB1/NIK cascade
Miyuki Suzawa, Ichiro Takada, Junn Yanagisawa, Fumiaki Ohtake, Satoko Ogawa, Toshimasa Yamauchi, Takashi Kadowaki, Yasuhiro Takeuchi, Hiroshi Shibuya, Yukiko Gotoh, Kunihiro Matsumoto and Shigeaki Kato
Nature Cell Biology 5, 224–230
(March 2003); doi:10.1038/ncb942
| First Paragraph | Full Text (HTML/PDF) |
news and views
GNOM alone
Donald Mcdonald
Nature Cell Biology 5, 189
(March 2003); doi:10.1038/ncb0303-189
| Full Text (HTML/PDF) |
review article
Mannose 6-phosphate receptors: new twists in the tale
Pradipta Ghosh, Nancy M. Dahms and Stuart Kornfeld
Nature Reviews Molecular Cell Biology 4, 202–213
(March 2003); doi:10.1038/nrm1050
| Summary | Full Text (HTML / PDF) |
perspective
Integration from proteins to organs: the Physiome Project
Peter J. Hunter and Thomas K. Borg
Nature Reviews Molecular Cell Biology 4, 237–243
(March 2003); doi:10.1038/nrm1054
| Summary | Full Text (HTML / PDF) |
article
PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction
Harumi Suzuki, Satoshi Matsuda, Yasuo Terauchi, Mari Fujiwara, Toshiaki Ohteki, Tomoichiro Asano, Timothy W. Behrens, Taku Kouro, Kiyoshi Takatsu, Takashi Kadowaki and Shigeo Koyasu
Nature Immunology 4, 280–286
(March 2003); doi:10.1038/ni890
| Abstract | Full Text (HTML/PDF) |
article
Lineage relationship and protective immunity of memory CD8 T cell subsets
E. John Wherry, Volker Teichgräber, Todd C. Becker, David Masopust, Susan M. Kaech, Rustom Antia, Ulrich H. von Andrian and Rafi Ahmed
Nature Immunology 4, 225–234
(March 2003); doi:10.1038/ni889
| Abstract | Full Text (HTML/PDF) |
news and views
Memory lanes
Vladimir P. Badovinac and John T. Harty
Nature Immunology 4, 212–213
(March 2003); doi:10.1038/ni0303-212
| Full Text (HTML/PDF) |
article
Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function
Amy N. Anzelon, Hong Wu and Robert C. Rickert
Nature Immunology 4, 287–294
(March 2003); doi:10.1038/ni892
| Abstract | Full Text (HTML/PDF) |
review article
Janus-like role of regulatory iNKT cells in autoimmune disease and tumour immunity
S. Brian Wilson and Terry L. Delovitch
Nature Reviews Immunology 3, 211–222
(March 2003); doi:10.1038/nri1028
| Summary | Full Text (HTML / PDF) |
article
A novel viral mechanism for dysregulation of β-catenin in Kaposi's sarcoma-associated herpesvirus latency
Masahiro Fujimuro, Frederick Y. Wu, Colette apRhys, Henry Kajumbula, David B. Young, Gary S. Hayward and S. Diane Hayward
Nature Medicine 9, 300–306
(March 2003); doi:10.1038/nm829
| Abstract | Full Text (HTML/PDF) |
news and views
Kaposi virus scores cancer coup
Chris Boshoff
Nature Medicine 9, 261–262
(March 2003); doi:10.1038/nm0303-261
| Full Text (HTML/PDF) |
article
PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect
Sorin Tunaru, Jukka Kero, Annette Schaub, Christian Wufka, Andree Blaukat, Klaus Pfeffer and Stefan Offermanns
Nature Medicine 9, 352–355
(March 2003); doi:10.1038/nm824
| Abstract | Full Text (HTML/PDF) |
news and views
Arrhythmias of the heart: beyond ion channels
Andrew R. Marks
Nature Medicine 9, 263–264
(March 2003); doi:10.1038/nm0303-263
| Full Text (HTML/PDF) |
news and views
Neurons inhibit neurogenesis
Nicholas B. Hastings and Elizabeth Gould
Nature Medicine 9, 264–266
(March 2003); doi:10.1038/nm0303-264
| Full Text (HTML/PDF) |
review article
Does the ribosome translate cancer?
Davide Ruggero and Pier Paolo Pandolfi
Nature Reviews Cancer 3, 179–192
(March 2003); doi:10.1038/nrc1015
| Summary | Full Text (HTML / PDF) |
letter
Notch1 functions as a tumor suppressor in mouse skin
Michael Nicolas, Anita Wolfer, Kenneth Raj, J. Alain Kummer, Pleasantine Mill, Mascha van Noort, Chi-chung Hui, Hans Clevers, G. Paolo Dotto and Freddy Radtke
Nature Genetics 33, 416–421
(March 2003); doi:10.1038/ng1099
| First Paragraph | Full Text (HTML/PDF) |
letter
Mice deficient in protein tyrosine phosphatase receptor type Z are resistant to gastric ulcer induction by VacA of Helicobacter pylori
Akihiro Fujikawa, Daisuke Shirasaka, Shoichi Yamamoto, Hiroyoshi Ota, Kinnosuke Yahiro, Masahide Fukada, Takafumi Shintani, Akihiro Wada, Nobuo Aoyama, Toshiya Hirayama, Hiroshi Fukamachi and Masaharu Noda
Nature Genetics 33, 375–381
(March 2003); doi:10.1038/ng1112
| First Paragraph | Full Text (HTML/PDF) |
news and views
Intoxicated cells and stomach ulcers
Richard M. Peek Jr.
Nature Genetics 33, 328–330
(March 2003); doi:10.1038/ng0303-328
| Full Text (HTML/PDF) |
article
Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system
Michael D. Ehlers
Nature Neuroscience 6, 231–242
(March 2003); doi:10.1038/nn1013
| Abstract | Full Text (HTML/PDF) |
article
An evolutionarily conserved dileucine motif in Shal K+ channels mediates dendritic targeting
Jacqueline F. Rivera, Shoeb Ahmad, Michael W. Quick, Emily R. Liman and Don B. Arnold
Nature Neuroscience 6, 243–250
(March 2003); doi:10.1038/nn1020
| Abstract | Full Text (HTML/PDF) |
article
Attenuation of a phosphorylation-dependent activator by an HDAC-PP1 complex
Gianluca Canettieri, Ianessa Morantte, Ernesto Guzmán, Hiroshi Asahara, Stephan Herzig, Scott D. Anderson, John R. Yates and III Marc Montminy
Nature Structural Biology 10, 175–181
(March 2003); doi:10.1038/nsb895
| Abstract | Full Text (HTML/PDF) |
news and views
The decline of induced transcription: a case of enzymatic symbiosis
Paolo Sassone-Corsi
Nature Structural Biology 10, 151–152
(March 2003); doi:10.1038/nsb0303-151
| Full Text (HTML/PDF) |
article
Crystal structure of a MARCKS peptide containing the calmodulin-binding domain in complex with Ca2+-calmodulin
Emiko Yamauchi, Toru Nakatsu, Mamoru Matsubara, Hiroaki Kato and Hisaaki Taniguchi
Nature Structural Biology 10, 226–231
(March 2003); doi:10.1038/nsb900
| Abstract | Full Text (HTML/PDF) |
news and views
Ready to partner
Mark X. Sliwkowski
Nature Structural Biology 10, 158–159
(March 2003); doi:10.1038/nsb0303-158
| Full Text (HTML/PDF) |
research article
An integrated functional genomics screening program reveals a role for BMP-9 in glucose homeostasis
Cecil Chen, Krzysztof J. Grzegorzewski, Steve Barash, Qinghai Zhao, Helmut Schneider, Qi Wang, Mallika Singh, Laurie Pukac, Adam C. Bell, Roxanne Duan, Tim Coleman, Alokesh Duttaroy, Susan Cheng, Jon Hirsch, Linyi Zhang, Yanick Lazard, Carrie Fischer, Melisa Carey Barber, Zhi-Dong Ma, Ya-Qin Zhang, Peter Reavey, Lilin Zhong, Baiqin Teng, Indra Sanyal, Steve M. Ruben, Olivier Blondel and Charles E. Birse
Nature Biotechnology 21, 294–301
(March 2003); doi:10.1038/nbt795
| Abstract | Full Text (HTML/PDF) |
research news
Bringing diabetes therapeutics to the big screen
Leif Groop
Nature Biotechnology 21, 240–241
(March 2003); doi:10.1038/nbt0303-240
| Full Text (HTML/PDF) |
research article
In situ assembly of enzyme inhibitors using extended tethering
Daniel A. Erlanson, Joni W. Lam, Christian Wiesmann, Tinh N. Luong, Robert L. Simmons, Warren L. DeLano, Ingrid C. Choong, Matthew T. Burdett, W. Michael Flanagan, Dennis Lee, Eric M. Gordon and Tom O'Brien
Nature Biotechnology 21, 308–314
(March 2003); doi:10.1038/nbt786
| Abstract | Full Text (HTML/PDF) |
letters to nature
Glycine binding primes NMDA receptor internalization
Yi Nong, Yue-Qiao Huang, William Ju, Lorraine V. Kalia, Gholamreza Ahmadian, Yu Tian Wang and Michael W. Salter
Nature 422, 302–307
(20 March 2003); doi:10.1038/nature01497
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer
D. Neil Watkins, David M. Berman, Scott G. Burkholder, Baolin Wang, Philip A. Beachy and Stephen B. Baylin
Nature 422, 313–317
(20 March 2003); doi:10.1038/nature01493
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Links between signal transduction, transcription and adhesion in epithelial bud development
Colin Jamora, Ramanuj DasGupta, Pawel Kocieniewski and Elaine Fuchs
Nature 422, 317–322
(20 March 2003); doi:10.1038/nature01458
| First Paragraph | Full Text (HTML / PDF) |
news and views
Developmental biology: A hairy situation
Yann Barrandon
Nature 422, 272–273
(20 March 2003); doi:10.1038/422272a
| Full Text (HTML / PDF) |
letters to nature
Segregation of receptor and ligand regulates activation of epithelial growth factor receptor
Paola D. Vermeer, Lisa A. Einwalter, Thomas O. Moninger, Tatiana Rokhlina, Jeffrey A. Kern, Joseph Zabner and Michael J. Welsh
Nature 422, 322–326
(20 March 2003); doi:10.1038/nature01440
| First Paragraph | Full Text (HTML / PDF) |
news and views
Cell biology: Just mix and patch
Keith Mostov and Mirjam Zegers
Nature 422, 267–268
(20 March 2003); doi:10.1038/422267a
| Full Text (HTML / PDF) |
letters to nature
The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl
Jörg Betschinger, Karl Mechtler and Juergen A. Knoblich
Nature 422, 326–330
(20 March 2003); doi:10.1038/nature01486
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8
Helen Walden, Michael S. Podgorski and Brenda A. Schulman
Nature 422, 330–334
(20 March 2003); doi:10.1038/nature01456
| First Paragraph | Full Text (HTML / PDF) |
letter
Redox-dependent downregulation of Rho by Rac
Anjaruwee S. Nimnual, Laura J. Taylor and Dafna Bar-Sagi
Nature Cell Biology 5, 236–241
(March 2003); doi:10.1038/ncb938
| First Paragraph | Full Text (HTML/PDF) |
news and views
Rac signalling: a radical view
Emmanuelle Caron
Nature Cell Biology 5, 185–187
(March 2003); doi:10.1038/ncb0303-185
| Full Text (HTML/PDF) |
article
RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase
Stéphane Gasman, Yannis Kalaidzidis and Marino Zerial
Nature Cell Biology 5, 195–204
(March 2003); doi:10.1038/ncb935
| Abstract | Full Text (HTML/PDF) |
letter
Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage
Claudia Lukas, Jacob Falck, Jirina Bartkova, Jiri Bartek and Jiri Lukas
Nature Cell Biology 5, 255–260
(March 2003); doi:10.1038/ncb945
| First Paragraph | Full Text (HTML/PDF) |
perspectives
Armadillo/β-catenin signals in the nucleus - proof beyond a reasonable doubt?
Mariann Bienz and Hans Clevers
Nature Cell Biology 5, 179–182
(March 2003); doi:10.1038/ncb0303-179
| Full Text (HTML/PDF) |
review article
How the ubiquitin-proteasome system controls transcription
Masafumi Muratani and William P. Tansey
Nature Reviews Molecular Cell Biology 4, 192–201
(March 2003); doi:10.1038/nrm1049
| Summary | Full Text (HTML / PDF) |
article
Angiogenins: a new class of microbicidal proteins involved in innate immunity
Lora V. Hooper, Thaddeus S. Stappenbeck, Chieu V. Hong and Jeffrey I. Gordon
Nature Immunology 4, 269–273
(March 2003); doi:10.1038/ni888
| Abstract | Full Text (HTML/PDF) |
news and views
Angiogenin: an antimicrobial ribonuclease
Tomas Ganz
Nature Immunology 4, 213–214
(March 2003); doi:10.1038/ni0303-213
| Full Text (HTML/PDF) |
review article
The nature of molecular recognition by T cells
Simon J. Davis, Shinji Ikemizu, Edward J. Evans, Lars Fugger, Talitha R. Bakker and P. Anton van der Merwe
Nature Immunology 4, 217–224
(March 2003); doi:10.1038/ni0303-217
| Abstract | Full Text (HTML/PDF) |
perspectives
Natural versus adaptive regulatory T cells
Jeffrey A. Bluestone and Abul K. Abbas
Nature Reviews Immunology 3, 253–257
(March 2003); doi:10.1038/nri1032
| Summary | Full Text (HTML / PDF) |
article
Suppression of experimental autoimmune encephalomyelitis by selective blockade of encephalitogenic T-cell infiltration of the central nervous system
Shirley Shidu Yan, Zhi-Ying Wu, Hui Ping Zhang, Glaucia Furtado, Xi Chen, Shi Fang Yan, Ann Marie Schmidt, Chris Brown, Alan Stern, Juan Lafaille, Leonard Chess, David M. Stern and Hong Jiang
Nature Medicine 9, 287–293
(March 2003); doi:10.1038/nm831
| Abstract | Full Text (HTML/PDF) |
review article
Neuroblastoma: biological insights into a clinical enigma
Garrett M. Brodeur
Nature Reviews Cancer 3, 203–216
(March 2003); doi:10.1038/nrc1014
| Summary | Full Text (HTML / PDF) |
letter
Dysregulation of TGF-β activation contributes to pathogenesis in Marfan syndrome
Enid R. Neptune, Pamela A. Frischmeyer, Dan E. Arking, Loretha Myers, Tracie E. Bunton, Barbara Gayraud, Francesco Ramirez, Lynn Y. Sakai and Harry C. Dietz
Nature Genetics 33, 407–411
(March 2003); doi:10.1038/ng1116
| First Paragraph | Full Text (HTML/PDF) |
news and views
Fibrillin controls TGF-β activation
Vesa Kaartinen and David Warburton
Nature Genetics 33, 331–332
(March 2003); doi:10.1038/ng0303-331
| Full Text (HTML/PDF) |
review article
Mice, microbes and models of infection
Jan Buer and Rudi Balling
Nature Reviews Genetics 4, 195–205
(March 2003); doi:10.1038/nrg1019
| Summary | Full Text (HTML / PDF) |
brief communication
Neurotrophin-4 mediated TrkB activation reinforces morphine-induced analgesia
Guilherme Lucas, Panu Hendolin, Tibor Harkany, Karin Agerman, Gustavo Paratcha, Carl Holmgren, Yuri Zilberter, Mikko Sairanen, Liliana Minichiello, Eero Castren and Patrik Ernfors
Nature Neuroscience 6, 221–222
(March 2003); doi:10.1038/nn1021
| First Paragraph | Full Text (HTML/PDF) |
article
Robo and Frazzled/DCC mediate dendritic guidance at the CNS midline
Marie-Pierre Furrer, Susan Kim, Brian Wolf and Akira Chiba
Nature Neuroscience 6, 223–230
(March 2003); doi:10.1038/nn1017
| Abstract | Full Text (HTML/PDF) |
article
Structure of Mycobacterium tuberculosis PknB supports a universal activation mechanism for Ser/Thr protein kinases
Tracy A. Young, Benedicte Delagoutte, James A. Endrizzi, Arnold M. Falick and Tom Alber
Nature Structural Biology 10, 168–174
(March 2003); doi:10.1038/nsb897
| Abstract | Full Text (HTML/PDF) |
letters to nature
Loss of integrin αvβ6-mediated TGF-β activation causes Mmp12-dependent emphysema
David G. Morris, Xiaozhu Huang, Naftali Kaminski, Yanli Wang, Steven D. Shapiro, Gregory Dolganov, Adam Glick and Dean Sheppard
Nature 422, 169–173
(13 March 2003); doi:10.1038/nature01413
| First Paragraph | Full Text (HTML / PDF) |
news and views
Medicine: Smoke signals for lung disease
Anita B. Roberts
Nature 422, 130–131
(13 March 2003); doi:10.1038/422130a
| Full Text (HTML / PDF) |
letters to nature
Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40
Yasuaki Itoh, Yuji Kawamata, Masataka Harada, Makoto Kobayashi, Ryo Fujii, Shoji Fukusumi, Kazuhiro Ogi, Masaki Hosoya, Yasuhiro Tanaka, Hiroshi Uejima, Hideyuki Tanaka, Minoru Maruyama, Rie Satoh, Shoichi Okubo, Hideki Kizawa, Hidetoshi Komatsu, Fumika Matsumura, Yuko Noguchi, Tokuyuki Shinohara, Shuji Hinuma, Yukio Fujisawa and Masahiko Fujino
Nature 422, 173–176
(13 March 2003); doi:10.1038/nature01478
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Functional and spatial segregation of secretory vesicle pools according to vesicle age
Rory R. Duncan, Jennifer Greaves, Ulrich K. Wiegand, Ioulia Matskevich, Georg Bodammer, David K. Apps, Michael J. Shipston and Robert H. Chow
Nature 422, 176–180
(13 March 2003); doi:10.1038/nature01389
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Functional analysis of an archaebacterial voltage-dependent K+ channel
Vanessa Ruta, Youxing Jiang, Alice Lee, Jiayun Chen and Roderick MacKinnon
Nature 422, 180–185
(13 March 2003); doi:10.1038/nature01473
| First Paragraph | Full Text (HTML / PDF) |
letter
Spontaneous receptor-independent heterotrimeric G-protein signalling in an RGS mutant
Daria E. Siekhaus and David G. Drubin
Nature Cell Biology 5, 231–235
(March 2003); doi:10.1038/ncb941
| First Paragraph | Full Text (HTML/PDF) |
letter
p53RDL1 regulates p53-dependent apoptosis
Chizu Tanikawa, Koichi Matsuda, Seisuke Fukuda, Yusuke Nakamura and Hirofumi Arakawa
Nature Cell Biology 5, 216–223
(March 2003); doi:10.1038/ncb943
| First Paragraph | Full Text (HTML/PDF) |
brief communication
The spindle-associated transmembrane protein Axs identifies a membranous structure ensheathing the meiotic spindle
Joseph Kramer and R. Scott Hawley
Nature Cell Biology 5, 261–263
(March 2003); doi:10.1038/ncb944
| First Paragraph | Full Text (HTML/PDF) |
review article
Signalling to and from tight junctions
Karl Matter and Maria S. Balda
Nature Reviews Molecular Cell Biology 4, 225–237
(March 2003); doi:10.1038/nrm1055
| Summary | Full Text (HTML / PDF) |
article
Defective thymocyte apoptosis and accelerated autoimmune diseases in TRAIL−/− mice
Salah-Eddine Lamhamedi-Cherradi, Shi-Jun Zheng, Kimberly A. Maguschak, Jacques Peschon and Youhai H. Chen
Nature Immunology 4, 255–260
(March 2003); doi:10.1038/ni894
| Abstract | Full Text (HTML/PDF) |
news and views
The suicide in the thymus, a twisted trail
Douglas R. Green
Nature Immunology 4, 207–208
(March 2003); doi:10.1038/ni0303-207
| Full Text (HTML/PDF) |
article
The thrombomodulin-protein C system is essential for the maintenance of pregnancy
Berend Isermann, Rashmi Sood, Rafal Pawlinski, Mark Zogg, Shawn Kalloway, Jay L. Degen, Nigel Mackman and Hartmut Weiler
Nature Medicine 9, 331–337
(March 2003); doi:10.1038/nm825
| Abstract | Full Text (HTML/PDF) |
article
Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective
Tong Cheng, Dong Liu, John H. Griffin, José A. Fernández, Francis Castellino, Elliot D. Rosen, Kenji Fukudome and Berislav V. Zlokovic
Nature Medicine 9, 338–342
(March 2003); doi:10.1038/nm826
| Abstract | Full Text (HTML/PDF) |
news and views
PAR1 signaling: more good than harm?
Wolfram Ruf
Nature Medicine 9, 258–260
(March 2003); doi:10.1038/nm0303-258
| Full Text (HTML/PDF) |
letter
Impaired response to interferon-α/β and lethal viral disease in human STAT1 deficiency
Stéphanie Dupuis, Emmanuelle Jouanguy, Sami Al-Hajjar, Claire Fieschi, Ibrahim Zaid Al-Mohsen, Suliman Al-Jumaah, Kun Yang, Ariane Chapgier, Céline Eidenschenk, Pierre Eid, Abdulaziz Al Ghonaium, Haysam Tufenkeji, Husn Frayha, Suleiman Al-Gazlan, Hassan Al-Rayes, Robert D. Schreiber, Ion Gresser and Jean-Laurent Casanova
Nature Genetics 33, 388–391
(March 2003); doi:10.1038/ng1097
| First Paragraph | Full Text (HTML/PDF) |
review article
Dying for a cause: invertebrate genetics takes on human neurodegeneration
Monica Driscoll and Beate Gerstbrein
Nature Reviews Genetics 4, 181–194
(March 2003); doi:10.1038/nrg1018
| Summary | Full Text (HTML / PDF) |
article
Dynamic balance of metabotropic inputs causes dorsal horn neurons to switch functional states
Dominique Derjean, Sandrine Bertrand, Gwendal Le Masson, Marc Landry, Valérie Morisset and Frédéric Nagy
Nature Neuroscience 6, 274–281
(March 2003); doi:10.1038/nn1016
| Abstract | Full Text (HTML/PDF) |
news and views
Plateau properties in pain pathways
Eve Marder
Nature Neuroscience 6, 210–212
(March 2003); doi:10.1038/nn0303-210
| Full Text (HTML/PDF) |
article
Elimination and strengthening of glycinergic/GABAergic connections during tonotopic map formation
Gunsoo Kim and Karl Kandler
Nature Neuroscience 6, 282–290
(March 2003); doi:10.1038/nn1015
| Abstract | Full Text (HTML/PDF) |
brief communication
Translocation of CaM kinase II to synaptic sites in vivo
Michelle R. Gleason, Shin-ichi Higashijima, Julia Dallman, Katharine Liu, Gail Mandel and Joseph R. Fetcho
Nature Neuroscience 6, 217–218
(March 2003); doi:10.1038/nn1011
| First Paragraph | Full Text (HTML/PDF) |
letters to nature
Regulated degradation of a class V myosin receptor directs movement of the yeast vacuole
Fusheng Tang, Emily J. Kauffman, Jennifer L. Novak, Johnathan J. Nau, Natalie L. Catlett and Lois S. Weisman
Nature 422, 87–92
(06 March 2003); doi:10.1038/nature01453
| First Paragraph | Full Text (HTML / PDF) |
news and views
Immunology: Fast and feel good?
Vijay K. Kuchroo and Lindsay B. Nicholson
Nature 422, 27–28
(06 March 2003); doi:10.1038/422027a
| Full Text (HTML / PDF) |
review article
Regulated portals of entry into the cell
Sean D. Conner and Sandra L. Schmid
Nature 422, 37–44
(06 March 2003); doi:10.1038/nature01451
| Summary | Full Text (HTML / PDF) |
letter
Mutated APC and Asef are involved in the migration of colorectal tumour cells
Yoshihiro Kawasaki, Rina Sato and Tetsu Akiyama
Nature Cell Biology 5, 211–215
(March 2003); doi:10.1038/ncb937
| First Paragraph | Full Text (HTML/PDF) |
news and views
The multiple functions of tumour suppressors: it's all in APC
Riccardo Fodde
Nature Cell Biology 5, 190–192
(March 2003); doi:10.1038/ncb0303-190
| Full Text (HTML/PDF) |
letter
A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly
Ming-Ying Tsai, Christiane Wiese, Kan Cao, Ona Martin, Peter Donovan, Joan Ruderman, Claude Prigent and Yixian Zheng
Nature Cell Biology 5, 242–248
(March 2003); doi:10.1038/ncb936
| First Paragraph | Full Text (HTML/PDF) |
review article
Signal dispersal and transduction through the endocytic pathway
Marcos González-Gaitán
Nature Reviews Molecular Cell Biology 4, 213–224
(March 2003); doi:10.1038/nrm1053
| Summary | Full Text (HTML / PDF) |
article
TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways
Irena Štefanová, Bernhard Hemmer, Marco Vergelli, Roland Martin, William E. Biddison and Ronald N. Germain
Nature Immunology 4, 248–254
(March 2003); doi:10.1038/ni895
| Abstract | Full Text (HTML/PDF) |
news and views
Tuning the immune system: competing positive and negative feedback loops
Daniel L. Mueller
Nature Immunology 4, 210–211
(March 2003); doi:10.1038/ni0303-210
| Full Text (HTML/PDF) |
article
Essential role of Src-family protein tyrosine kinases in NF-κB activation during B cell development
Kaoru Saijo, Christian Schmedt, I-hsin Su, Hajime Karasuyama, Clifford A. Lowell, Michael Reth, Takahiro Adachi, Alina Patke, Angela Santana and Alexander Tarakhovsky
Nature Immunology 4, 274–279
(March 2003); doi:10.1038/ni893
| Abstract | Full Text (HTML/PDF) |
article
Toll-like receptor-4 (TLR4) signaling augments chemokine-induced neutrophil migration by modulating cell surface expression of chemokine receptors
Jie Fan and Asrar B. Malik
Nature Medicine 9, 315–321
(March 2003); doi:10.1038/nm832
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RNA interference targeting Fas protects mice from fulminant hepatitis
Erwei Song, Sang-Kyung Lee, Jie Wang, Nedim Ince, Nengtai Ouyang, Jun Min, Jisheng Chen, Premlata Shankar and Judy Lieberman
Nature Medicine 9, 347–351
(March 2003); doi:10.1038/nm828
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siRNAs knock down hepatitis
Phillip D. Zamore and Neil Aronin
Nature Medicine 9, 266–267
(March 2003); doi:10.1038/nm0303-266
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review article
ATM and related protein kinases: safeguarding genome integrity
Yosef Shiloh
Nature Reviews Cancer 3, 155–168
(March 2003); doi:10.1038/nrc1011
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The codon 72 polymorphic variants of p53 have markedly different apoptotic potential
Patrick Dumont, J. I-Ju Leu, Anthony C. Della Pietra, III Donna L. George and Maureen Murphy
Nature Genetics 33, 357–365
(March 2003); doi:10.1038/ng1093
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review article
Comparative plant development: the time of the leaf?
Miltos Tsiantis and Angela Hay
Nature Reviews Genetics 4, 169–180
(March 2003); doi:10.1038/nrg1002
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A role for CK2 in the Drosophila circadian oscillator
Bikem Akten, Eike Jauch, Ginka K. Genova, Eun Young Kim, Isaac Edery, Thomas Raabe and F. Rob Jackson
Nature Neuroscience 6, 251–257
(March 2003); doi:10.1038/nn1007
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A new role for an old kinase: CK2 and the circadian clock
Justin Blau
Nature Neuroscience 6, 208–210
(March 2003); doi:10.1038/nn0303-208
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research article
A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling
Blagoy Blagoev, Irina Kratchmarova, Shao-En Ong, Mogens Nielsen, Leonard J. Foster and Matthias Mann
Nature Biotechnology 21, 315–318
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