Research library: browse by date
May 2003
2003:
December |
November |
October |
September |
August |
July |
June |
May |
April |
March |
February |
January
Other years: 2002 | 2004 | 2005 | 2006 | 2007
The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.
Click here for free access to the 'Featured Articles' section, with new articles every week.
 Click here to browse by subject
article
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
Hironori Ueda, Joanna M. M. Howson, Laura Esposito, Joanne Heward, Hywel Snook, Giselle Chamberlain, Daniel B. Rainbow, Kara M. D. Hunter, Annabel N. Smith, Gianfranco Di Genova, Mathias H. Herr, Ingrid Dahlman, Felicity Payne, Deborah Smyth, Christopher Lowe, Rebecca C. J. Twells, Sarah Howlett, Barry Healy, Sarah Nutland, Helen E. Rance, Vin Everett, Luc J. Smink, Alex C. Lam, Heather J. Cordell, Neil M. Walker, Cristina Bordin, John Hulme, Costantino Motzo, Francesco Cucca, J. Fred Hess, Michael L. Metzker, Jane Rogers, Simon Gregory, Amit Allahabadia, Ratnasingam Nithiyananthan, Eva Tuomilehto-Wolf, Jaakko Tuomilehto, Polly Bingley, Kathleen M. Gillespie, Dag E. Undlien, Kjersti S. Rønningen, Cristian Guja, Constantin Ionescu-Tîrgoviste, David A. Savage, A. Peter Maxwell, Dennis J. Carson, Chris C. Patterson, Jayne A. Franklyn, David G. Clayton, Laurence B. Peterson, Linda S. Wicker, John A. Todd and Stephen C. L. Gough
Nature 423, 506–511
(29 May 2003); doi:10.1038/nature01621
| Summary | Full Text (HTML / PDF) |
article
Structure of the replicative helicase of the oncoprotein SV40 large tumour antigen
Dawei Li, Rui Zhao, Wayne Lilyestrom, Dahai Gai, Rongguang Zhang, James A. DeCaprio, Ellen Fanning, Andrzej Jochimiak, Gerda Szakonyi and Xiaojiang S. Chen
Nature 423, 512–518
(29 May 2003); doi:10.1038/nature01691
| Summary | Full Text (HTML / PDF) |
letters to nature
Mitochondrial membrane remodelling regulated by a conserved rhomboid protease
G. Angus McQuibban, Saroj Saurya and Matthew Freeman
Nature 423, 537–541
(29 May 2003); doi:10.1038/nature01633
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
Kazutoshi Takahashi, Kaoru Mitsui and Shinya Yamanaka
Nature 423, 541–545
(29 May 2003); doi:10.1038/nature01646
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Modulation of oestrogen receptor signalling by association with the activated dioxin receptor
Fumiaki Ohtake, Ken-ichi Takeyama, Takahiro Matsumoto, Hirochika Kitagawa, Yasuji Yamamoto, Keiko Nohara, Chiharu Tohyama, Andree Krust, Junsei Mimura, Pierre Chambon, Junn Yanagisawa, Yoshiaki Fujii-Kuriyama and Shigeaki Kato
Nature 423, 545–550
(29 May 2003); doi:10.1038/nature01606
| First Paragraph | Full Text (HTML / PDF) |
news and views
Gene expression: Oestrogen receptor hijacked
Jan J. Brosens and Malcolm G. Parker
Nature 423, 487–488
(29 May 2003); doi:10.1038/423487a
| Full Text (HTML / PDF) |
letters to nature
Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1α interaction
Pere Puigserver, James Rhee, Jerry Donovan, Christopher J. Walkey, J. Cliff Yoon, Francesco Oriente, Yukari Kitamura, Jennifer Altomonte, Hengjiang Dong, Domenico Accili and Bruce M. Spiegelman
Nature 423, 550–555
(29 May 2003); doi:10.1038/nature01667
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors
Zhulun Wang, Gérard Benoit, Jinsong Liu, Srividya Prasad, Piia Aarnisalo, Xiaohong Liu, Haoda Xu, Nigel P. C. Walker and Thomas Perlmann
Nature 423, 555–560
(29 May 2003); doi:10.1038/nature01645
| First Paragraph | Full Text (HTML / PDF) |
news and views
Cell division: Genome maintenance
Jordan W. Raff
Nature 423, 493–495
(29 May 2003); doi:10.1038/423493a
| Full Text (HTML / PDF) |
letter
Regulation of calcium signals in the nucleus by a nucleoplasmic reticulum
Wihelma Echevarría, M. Fatima Leite, Mateus T. Guerra, Warren R. Zipfel and Michael H. Nathanson
Nature Cell Biology 5, 440–446
(May 2003); doi:10.1038/ncb980
| First Paragraph | Full Text (HTML/PDF) |
letter
Polo-like kinase Cdc5 promotes chiasmata formation and cosegregation of sister centromeres at meiosis I
Rosemary K. Clyne, Vittorio L. Katis, Lea Jessop, Kirsten R. Benjamin, Ira Herskowitz, Michael Lichten and Kim Nasmyth
Nature Cell Biology 5, 480–485
(May 2003); doi:10.1038/ncb977
| First Paragraph | Full Text (HTML/PDF) |
news and views
Monopolar attachment by Polo
Yoshinori Watanabe
Nature Cell Biology 5, 379–382
(May 2003); doi:10.1038/ncb0503-379
| Full Text (HTML/PDF) |
news and views
Morphogens recycled
A Schuldt
Nature Cell Biology 5, 376
(May 2003); doi:10.1038/ncb0503-376
| Full Text (HTML/PDF) |
perspectives
Coat proteins: shaping membrane transport
Juan S. Bonifacino and Jennifer Lippincott-Schwartz
Nature Reviews Molecular Cell Biology 4, 409–414
(May 2003); doi:10.1038/nrm1099
| Summary | Full Text (HTML / PDF) |
article
Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cells
Julio Aliberti, Jesus G. Valenzuela, Vern B. Carruthers, Sara Hieny, John Andersen, Hugues Charest, Caetano Reis e Sousa, Alan Fairlamb, Jose M. Ribeiro and Alan Sher
Nature Immunology 4, 485–490
(May 2003); doi:10.1038/ni915
| Abstract | Full Text (HTML/PDF) |
review article
Caspase-independent cell death in T lymphocytes
Marja Jäättelä and Jürg Tschopp
Nature Immunology 4, 416–423
(May 2003); doi:10.1038/ni0503-416
| Abstract | Full Text (HTML/PDF) |
review article
What does it take to make a natural killer?
Francesco Colucci, Michael A. Caligiuri and James P. Di Santo
Nature Reviews Immunology 3, 413–425
(May 2003); doi:10.1038/nri1088
| Summary | Full Text (HTML / PDF) |
article
Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2
Renhai Cao, Ebba Bråkenhielm, Robert Pawliuk, David Wariaro, Mark J. Post, Eric Wahlberg, Philippe Leboulch and Yihai Cao
Nature Medicine 9, 604–613
(May 2003); doi:10.1038/nm848
| Abstract | Full Text (HTML/PDF) |
article
Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo
Joseph N. Blattman, Jason M. Grayson, E. John Wherry, Susan M. Kaech, Kendall A. Smith and Rafi Ahmed
Nature Medicine 9, 540–547
(May 2003); doi:10.1038/nm866
| Abstract | Full Text (HTML/PDF) |
news and views
Calcium and heart failure: the cycle game
Kenneth R. Chien, John Ross and Jr. Masahiko Hoshijima
Nature Medicine 9, 508–509
(May 2003); doi:10.1038/nm0503-508
| Full Text (HTML/PDF) |
news and views
Platelet attraction
Charlotte Schubert
Nature Medicine 9, 511
(May 2003); doi:10.1038/nm0503-511
| Full Text (HTML/PDF) |
news and views
Mastering innate immunity
Robert M. Strieter
Nature Medicine 9, 512–513
(May 2003); doi:10.1038/nm0503-512
| Full Text (HTML/PDF) |
article
Tissue-specific nuclear architecture and gene expession regulated by SATB1
Shutao Cai, Hye-Jung Han and Terumi Kohwi-Shigematsu
Nature Genetics 34, 42–51
(May 2003); doi:10.1038/ng1146
| Abstract | Full Text (HTML/PDF) |
news and views
A nuclear address with influence
M. Frances Shannon
Nature Genetics 34, 4–6
(May 2003); doi:10.1038/ng0503-4
| Full Text (HTML/PDF) |
article
Vomeronasal organ detects odorants in absence of signaling through main olfactory epithelium
Kien Trinh and Daniel R. Storm
Nature Neuroscience 6, 519–525
(May 2003); doi:10.1038/nn1039
| Abstract | Full Text (HTML/PDF) |
news and views
Nosing into pheromone detectors
Ivan Rodriguez
Nature Neuroscience 6, 438–440
(May 2003); doi:10.1038/nn0503-438
| Full Text (HTML/PDF) |
review article
Such stuff as dreams are made on: mediator-directed therapy in sepsis
John C. Marshall
Nature Reviews Drug Discovery 2, 391–405
(May 2003); doi:10.1038/nrd1084
| Summary | Full Text (HTML / PDF) |
article
Crystal structure of the BAFF-BAFF-R complex and its implications for receptor activation
Ho Min Kim, Kyung Sook Yu, Mi Eun Lee, Dong Ryeol Shin, Young Sang Kim, Sang-Gi Paik, Ook Joon Yoo, Hayyoung Lee and Jie-Oh Lee
Nature Structural Biology 10, 342–348
(May 2003); doi:10.1038/nsb925
| Abstract | Full Text (HTML/PDF) |
article
A role for Wnt signalling in self-renewal of haematopoietic stem cells
Tannishtha Reya, Andrew W. Duncan, Laurie Ailles, Jos Domen, David C. Scherer, Karl Willert, Lindsay Hintz, Roel Nusse and Irving L. Weissman
Nature 423, 409–414
(22 May 2003); doi:10.1038/nature01593
| Abstract | Full Text (HTML / PDF) |
letters to nature
Wnt proteins are lipid-modified and can act as stem cell growth factors
Karl Willert, Jeffrey D. Brown, Esther Danenberg, Andrew W. Duncan, Irving L. Weissman, Tannishtha Reya, John R. Yates III and Roel Nusse
Nature 423, 448–452
(22 May 2003); doi:10.1038/nature01611
| First Paragraph | Full Text (HTML / PDF) |
news and views
Alzheimer's disease: Mental plaque removal
Bart De Strooper and James Woodgett
Nature 423, 392–393
(22 May 2003); doi:10.1038/423392a
| Full Text (HTML / PDF) |
letters to nature
GSK-3α regulates production of Alzheimer's disease amyloid-β peptides
Christopher J. Phiel, Christina A. Wilson, Virginia M.-Y. Lee and Peter S. Klein
Nature 423, 435–439
(22 May 2003); doi:10.1038/nature01640
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Caenorhabditis elegans early embryogenesis and vulval morphogenesis require chondroitin biosynthesis
Ho-Yon Hwang, Sara K. Olson, Jeffrey D. Esko and H. Robert Horvitz
Nature 423, 439–443
(22 May 2003); doi:10.1038/nature01634
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Chondroitin proteoglycans are involved in cell division of Caenorhabditis elegans
Souhei Mizuguchi, Toru Uyama, Hiroshi Kitagawa, Kazuko H. Nomura , Katsufumi Dejima, Keiko Gengyo-Ando, Shohei Mitani, Kazuyuki Sugahara and Kazuya Nomura
Nature 423, 443–448
(22 May 2003); doi:10.1038/nature01635
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Deficiency of the adaptor SLP-65 in pre-B-cell acute lymphoblastic leukaemia
Hassan Jumaa, Lukas Bossaller, Karina Portugal, Bettina Storch, Michael Lotz, Alexandra Flemming, Martin Schrappe, Ville Postila, Pekka Riikonen, Jukka Pelkonen, Charlotte M. Niemeyer and Michael Reth
Nature 423, 452–456
(22 May 2003); doi:10.1038/nature01608
| First Paragraph | Full Text (HTML / PDF) |
letter
Progressive hearing loss in mice lacking the cyclin-dependent kinase inhibitor Ink4d
Ping Chen, Frederique Zindy, Caroline Abdala, Feng Liu, Xiankui Li, Martine F. Roussel and Neil Segil
Nature Cell Biology 5, 422–426
(May 2003); doi:10.1038/ncb976
| First Paragraph | Full Text (HTML/PDF) |
news and views
Deafening cycle
Bridget Baumgartner and J. Wade Harper
Nature Cell Biology 5, 385–387
(May 2003); doi:10.1038/ncb0503-385
| Full Text (HTML/PDF) |
letter
Degradation of DIAP1 by the N-end rule pathway is essential for regulating apoptosis
Mark Ditzel, Rebecca Wilson, Tencho Tenev, Anna Zachariou, Angela Paul, Emma Deas and Pascal Meier
Nature Cell Biology 5, 467–473
(May 2003); doi:10.1038/ncb984
| First Paragraph | Full Text (HTML/PDF) |
news and views
The N-end rule and regulation of apoptosis
Alexander Varshavsky
Nature Cell Biology 5, 373–376
(May 2003); doi:10.1038/ncb0503-373
| Full Text (HTML/PDF) |
review article
Sphingosine-1-phosphate: an enigmatic signalling lipid
Sarah Spiegel and Sheldon Milstien
Nature Reviews Molecular Cell Biology 4, 397–407
(May 2003); doi:10.1038/nrm1103
| Summary | Full Text (HTML / PDF) |
article
The Drosophila immune system detects bacteria through specific peptidoglycan recognition
François Leulier, Claudine Parquet, Sebastien Pili-Floury, Ji-Hwan Ryu, Martine Caroff, Won-Jae Lee, Dominique Mengin-Lecreulx and Bruno Lemaitre
Nature Immunology 4, 478–484
(May 2003); doi:10.1038/ni922
| Abstract | Full Text (HTML/PDF) |
review article
Apoptosis in the development and maintenance of the immune system
Joseph T. Opferman and Stanley J. Korsmeyer
Nature Immunology 4, 410–415
(May 2003); doi:10.1038/ni0503-410
| Abstract | Full Text (HTML/PDF) |
review article
Apoptosis as an HIV strategy to escape immune attack
Marie-Lise Gougeon
Nature Reviews Immunology 3, 392–404
(May 2003); doi:10.1038/nri1087
| Summary | Full Text (HTML / PDF) |
article
Disruption of the Fanconi anemia-BRCA pathway in cisplatin-sensitive ovarian tumors
Toshiyasu Taniguchi, Marc Tischkowitz, Najim Ameziane, Shirley V. Hodgson, Christopher G. Mathew, Hans Joenje, Samuel C. Mok and Alan D. D'Andrea
Nature Medicine 9, 568–574
(May 2003); doi:10.1038/nm852
| Abstract | Full Text (HTML/PDF) |
news and views
Cisplatin and the sensitive cell
Grover C. Bagby and Susan B. Olson
Nature Medicine 9, 513–514
(May 2003); doi:10.1038/nm0503-513
| Full Text (HTML/PDF) |
review article
Tumour-cell invasion and migration: diversity and escape mechanisms
Peter Friedl and Katarina Wolf
Nature Reviews Cancer 3, 362–374
(May 2003); doi:10.1038/nrc1075
| Summary | Full Text (HTML / PDF) |
brief communication
Dax1 is required for testis determination
Joshua J. Meeks, Jeffrey Weiss and J. Larry Jameson
Nature Genetics 34, 32–33
(May 2003); doi:10.1038/ng1141
| First Paragraph | Full Text (HTML/PDF) |
review article
Caenorhabditis elegans: an emerging genetic model for the study of innate immunity
C. Léopold Kurz and Jonathan J. Ewbank
Nature Reviews Genetics 4, 380–390
(May 2003); doi:10.1038/nrg1067
| Summary | Full Text (HTML / PDF) |
article
Modal gating of NMDA receptors and the shape of their synaptic response
Gabriela Popescu and Anthony Auerbach
Nature Neuroscience 6, 476–483
(May 2003); doi:10.1038/nn1044
| Abstract | Full Text (HTML/PDF) |
review article
Pharmacological strategies for muscular dystrophy
Tejvir S. Khurana and Kay E. Davies
Nature Reviews Drug Discovery 2, 379–390
(May 2003); doi:10.1038/nrd1085
| Summary | Full Text (HTML / PDF) |
article
Molecular mechanism of membrane recruitment of GGA by ARF in lysosomal protein transport
Tomoo Shiba, Masato Kawasaki, Hiroyuki Takatsu, Terukazu Nogi, Naohiro Matsugaki, Noriyuki Igarashi, Mamoru Suzuki, Ryuichi Kato, Kazuhisa Nakayama and Soichi Wakatsuki
Nature Structural Biology 10, 386–393
(May 2003); doi:10.1038/nsb920
| Abstract | Full Text (HTML/PDF) |
article
Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells
Julie Lessard and Guy Sauvageau
Nature 423, 255–260
(15 May 2003); doi:10.1038/nature01572
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
In-kyung Park, Dalong Qian, Mark Kiel, Michael W. Becker, Michael Pihalja, Irving L. Weissman, Sean J. Morrison and Michael F. Clarke
Nature 423, 302–305
(15 May 2003); doi:10.1038/nature01587
| First Paragraph | Full Text (HTML / PDF) |
news and views
Stem cells: Self-renewal writ in blood
John E. Dick
Nature 423, 231–233
(15 May 2003); doi:10.1038/423231a
| Full Text (HTML / PDF) |
letters to nature
DNA helicase Srs2 disrupts the Rad51 presynaptic filament
Lumir Krejci, Stephen Van Komen, Ying Li, Jana Villemain, Mothe Sreedhar Reddy, Hannah Klein, Thomas Ellenberger and Patrick Sung
Nature 423, 305–309
(15 May 2003); doi:10.1038/nature01577
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
The Srs2 helicase prevents recombination by disrupting Rad51 nucleoprotein filaments
Xavier Veaute, Josette Jeusset, Christine Soustelle, Stephen C. Kowalczykowski, Eric Le Cam and Francis Fabre
Nature 423, 309–312
(15 May 2003); doi:10.1038/nature01585
| First Paragraph | Full Text (HTML / PDF) |
news and views
Molecular biology: Disruptive influence
Marco Foiani
Nature 423, 234–235
(15 May 2003); doi:10.1038/423234a
| Full Text (HTML / PDF) |
news and views
Plant reproduction: Sex and self-denial
Ed Newbigin and Richard D. Vierstra
Nature 423, 229–230
(15 May 2003); doi:10.1038/423229a
| Full Text (HTML / PDF) |
review
Deciphering skeletal patterning: clues from the limb
Francesca V. Mariani and Gail R. Martin
Nature 423, 319–325
(15 May 2003); doi:10.1038/nature01655
| Summary | Full Text (HTML / PDF) |
review
Cranial skeletal biology
J. A. Helms and R. A. Schneider
Nature 423, 326–331
(15 May 2003); doi:10.1038/nature01656
| Summary | Full Text (HTML / PDF) |
review
Developmental regulation of the growth plate
Henry M. Kronenberg
Nature 423, 332–336
(15 May 2003); doi:10.1038/nature01657
| Summary | Full Text (HTML / PDF) |
review
Osteoclast differentiation and activation
William J. Boyle, W. Scott Simonet and David L. Lacey
Nature 423, 337–342
(15 May 2003); doi:10.1038/nature01658
| Summary | Full Text (HTML / PDF) |
review
The genetic basis for skeletal diseases
Elazar Zelzer and Bjorn R. Olsen
Nature 423, 343–348
(15 May 2003); doi:10.1038/nature01659
| Summary | Full Text (HTML / PDF) |
review
Control of osteoblast function and regulation of bone mass
Shun-ichi Harada and Gideon A. Rodan
Nature 423, 349–355
(15 May 2003); doi:10.1038/nature01660
| Summary | Full Text (HTML / PDF) |
review
Evolving concepts of rheumatoid arthritis
Gary S. Firestein
Nature 423, 356–361
(15 May 2003); doi:10.1038/nature01661
| Summary | Full Text (HTML / PDF) |
article
Chk2 activates E2F-1 in response to DNA damage
Craig Stevens, Linda Smith and Nicholas B. La Thangue
Nature Cell Biology 5, 401–409
(May 2003); doi:10.1038/ncb974
| Abstract | Full Text (HTML/PDF) |
letter
Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1
Atsuo Sasaki, Takaharu Taketomi, Reiko Kato, Kazuko Saeki, Atsushi Nonami, Mika Sasaki, Masamitsu Kuriyama, Naoaki Saito, Masabumi Shibuya and Akihiko Yoshimura
Nature Cell Biology 5, 427–432
(May 2003); doi:10.1038/ncb978
| First Paragraph | Full Text (HTML/PDF) |
news and views
Split personalities: the agonistic antagonist Sprouty
Gerhard Christofori
Nature Cell Biology 5, 377–379
(May 2003); doi:10.1038/ncb0503-377
| Full Text (HTML/PDF) |
letter
Translokin is an intracellular mediator of FGF-2 trafficking
Carine Bossard, Henrik Laurell, Loïc Van den Berghe, Sylvain Meunier, Catherine Zanibellato and Hervé Prats
Nature Cell Biology 5, 433–439
(May 2003); doi:10.1038/ncb979
| First Paragraph | Full Text (HTML/PDF) |
review article
Phagocyte sabotage: disruption of macrophage signalling by bacterial pathogens
Carrie M. Rosenberger and B. Brett Finlay
Nature Reviews Molecular Cell Biology 4, 385–396
(May 2003); doi:10.1038/nrm1104
| Summary | Full Text (HTML / PDF) |
article
Monoallelic expression of the murine gene encoding Toll-like receptor 4
João Pedro Pereira, Robert Girard, Richard Chaby, Ana Cumano and Paulo Vieira
Nature Immunology 4, 464–470
(May 2003); doi:10.1038/ni917
| Abstract | Full Text (HTML/PDF) |
review article
The death effector domain protein family: regulators of cellular homeostasis
Michael D. Tibbetts, Lixin Zheng and Michael J. Lenardo
Nature Immunology 4, 404–409
(May 2003); doi:10.1038/ni0503-404
| Abstract | Full Text (HTML/PDF) |
review article
Negative selection — clearing out the bad apples from the T-cell repertoire
Ed Palmer
Nature Reviews Immunology 3, 383–391
(May 2003); doi:10.1038/nri1085
| Summary | Full Text (HTML / PDF) |
perspectives
Cancer revoked: oncogenes as therapeutic targets
Dean W. Felsher
Nature Reviews Cancer 3, 375–379
(May 2003); doi:10.1038/nrc1070
| Summary | Full Text (HTML / PDF) |
brief communication
Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders
Bethan Jones, Emma L. Jones, Stephanie A. Bonney, Hetal N. Patel, Arjen R. Mensenkamp, Sophie Eichenbaum-Voline, Mats Rudling, Urban Myrdal, Grazia Annesi, Sandhia Naik, Nigel Meadows, Aldo Quattrone, Suhail A. Islam, Rossitza P. Naoumova, Bo Angelin, Recaredo Infante, Emile Levy, Claude C. Roy, Paul S. Freemont, James Scott and Carol C. Shoulders
Nature Genetics 34, 29–31
(May 2003); doi:10.1038/ng1145
| First Paragraph | Full Text (HTML/PDF) |
article
Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain
Eduardo Puelles, Dario Acampora, Emmanuel Lacroix, Massimo Signore, Alessandro Annino, Francesca Tuorto, Stefania Filosa, Giorgio Corte, Wolfgang Wurst, Siew-Lan Ang and Antonio Simeone
Nature Neuroscience 6, 453–460
(May 2003); doi:10.1038/nn1037
| Abstract | Full Text (HTML/PDF) |
review article
Mechanisms, challenges and opportunities in stroke
Eng H. Lo, Turgay Dalkara and Michael A. Moskowitz
Nature Reviews Neuroscience 4, 399–414
(May 2003); doi:10.1038/nrn1106
| Summary | Full Text (HTML / PDF) |
letters to nature
Defective membrane repair in dysferlin-deficient muscular dystrophy
Dimple Bansal, Katsuya Miyake, Steven S. Vogel, Séverine Groh, Chien-Chang Chen, Roger Williamson, Paul L. McNeil and Kevin P. Campbell
Nature 423, 168–172
(08 May 2003); doi:10.1038/nature01573
| First Paragraph | Full Text (HTML / PDF) |
news and views
Cell biology: Patches for wounded muscle
Juliet A. Ellis
Nature 423, 129–131
(08 May 2003); doi:10.1038/423129a
| Full Text (HTML / PDF) |
letters to nature
Identification of Vangl2 and Scrb1 as planar polarity genes in mammals
Mireille Montcouquiol, Rivka A. Rachel, Pamela J. Lanford, Neal G. Copeland, Nancy A. Jenkins and Matthew W. Kelley
Nature 423, 173–177
(08 May 2003); doi:10.1038/nature01618
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae
Rozalyn M. Anderson, Kevin J. Bitterman, Jason G. Wood, Oliver Medvedik and David A. Sinclair
Nature 423, 181–185
(08 May 2003); doi:10.1038/nature01578
| First Paragraph | Full Text (HTML / PDF) |
news and views
Molecular physiology: Tuned for longer life
Richard Turner
Nature 423, 125
(08 May 2003); doi:10.1038/423125a
| Full Text (HTML / PDF) |
letters to nature
Computational design of receptor and sensor proteins with novel functions
Loren L. Looger, Mary A. Dwyer, James J. Smith and Homme W. Hellinga
Nature 423, 185–190
(08 May 2003); doi:10.1038/nature01556
| First Paragraph | Full Text (HTML / PDF) |
news and views
Computational biology: Biosensor design
William F. DeGrado
Nature 423, 132–133
(08 May 2003); doi:10.1038/423132a
| Full Text (HTML / PDF) |
letters to nature
Direct observation of catch bonds involving cell-adhesion molecules
Bryan T. Marshall, Mian Long, James W. Piper, Tadayuki Yago, Rodger P. McEver and Cheng Zhu
Nature 423, 190–193
(08 May 2003); doi:10.1038/nature01605
| First Paragraph | Full Text (HTML / PDF) |
article
Distinct endocytic pathways regulate TGF-β receptor signalling and turnover
Gianni M. Di Guglielmo, Christine Le Roy, Anne F. Goodfellow and Jeffrey L. Wrana
Nature Cell Biology 5, 410–421
(May 2003); doi:10.1038/ncb975
| Abstract | Full Text (HTML/PDF) |
news and views
Sliding doors: clathrin-coated pits or caveolae?
Michela Felberbaum-Corti, Françoise Gisou Van Der Goot and Jean Gruenberg
Nature Cell Biology 5, 382–384
(May 2003); doi:10.1038/ncb0503-382
| Full Text (HTML/PDF) |
review article
Ras proteins: different signals from different locations
John F. Hancock
Nature Reviews Molecular Cell Biology 4, 373–385
(May 2003); doi:10.1038/nrm1105
| Summary | Full Text (HTML / PDF) |
article
Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock
Marina Karaghiosoff, Ralf Steinborn, Pavel Kovarik, Gernot Kriegshäuser, Manuela Baccarini, Birgit Donabauer, Ursula Reichart, Thomas Kolbe, Christian Bogdan, Tomas Leanderson, David Levy, Thomas Decker and Mathias Müller
Nature Immunology 4, 471–477
(May 2003); doi:10.1038/ni910
| Abstract | Full Text (HTML/PDF) |
news and views
CD8 and B cell memory: same strategy, same signals
Corinne Tanchot and Benedita Rocha
Nature Immunology 4, 431–432
(May 2003); doi:10.1038/ni0503-431
| Full Text (HTML/PDF) |
review article
NODs: intracellular proteins involved in inflammation and apoptosis
Naohiro Inohara and Gabriel Nuñez
Nature Reviews Immunology 3, 371–382
(May 2003); doi:10.1038/nri1086
| Summary | Full Text (HTML / PDF) |
perspectives
Re-evaluating the role of heat-shock protein-peptide interactions in tumour immunity
Christopher V. Nicchitta
Nature Reviews Immunology 3, 427–432
(May 2003); doi:10.1038/nri1089
| Summary | Full Text (HTML / PDF) |
article
Activation and regulation of Toll-like receptors 2 and 1 in human leprosy
Stephan R. Krutzik, Maria Teresa Ochoa, Peter A. Sieling, Satoshi Uematsu, Yolanda W. Ng, Annaliza Legaspi, Philip T. Liu, Stewart T. Cole, Paul J. Godowski, Yumi Maeda, Euzenir N. Sarno, Michael V. Norgard, Patrick J. Brennan, Shizuo Akira, Thomas H. Rea and Robert L. Modlin
Nature Medicine 9, 525–532
(May 2003); doi:10.1038/nm864
| Abstract | Full Text (HTML/PDF) |
review article
The circadian clock: pacemaker and tumour suppressor
Loning Fu and Cheng Chi Lee
Nature Reviews Cancer 3, 350–361
(May 2003); doi:10.1038/nrc1072
| Summary | Full Text (HTML / PDF) |
article
The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI
Toshihide Yamashita and Masaya Tohyama
Nature Neuroscience 6, 461–467
(May 2003); doi:10.1038/nn1045
| Abstract | Full Text (HTML/PDF) |
news and views
Axon growth inhibition: signals from the p75 neurotrophin receptor
David R. Kaplan and Freda D. Miller
Nature Neuroscience 6, 435–436
(May 2003); doi:10.1038/nn0503-435
| Full Text (HTML/PDF) |
article
Calpain silencing by a reversible intrinsic mechanism
Tudor Moldoveanu, Christopher M. Hosfield, Daniel Lim, Zongchao Jia and Peter L. Davies
Nature Structural Biology 10, 371–378
(May 2003); doi:10.1038/nsb917
| Abstract | Full Text (HTML/PDF) |
article
X-ray structure of a voltage-dependent K+ channel
Youxing Jiang, Alice Lee, Jiayun Chen, Vanessa Ruta, Martine Caden, Brian T. Chait and Roderick Mackinnon
Nature 423, 33–41
(1 May 2003); doi:10.1038/nature01580
| Abstract | Full Text (HTML / PDF) |
article
The principle of gating charge movement in a voltage-dependent K+ channel
Youxing Jiang, Vanessa Ruta, Jiayun Chen, Alice Lee and Roderick Mackinnon
Nature 423, 42–48
(1 May 2003); doi:10.1038/nature01581
| Abstract | Full Text (HTML / PDF) |
news and views
Structural biology: Life's transistors
Fred J. Sigworth
Nature 423, 21–22
(1 May 2003); doi:10.1038/423021a
| Full Text (HTML / PDF) |
review article
Ligand–receptor binding revealed by the TNF family member TALL-1
Yingfang Liu, Xia Hong, John Kappler, Ling Jiang, Rongguang Zhang, Liangguo Xu, Cheol-Ho Pan Wesley E. Martin, Robert C. Murphy, Hong-Bing Shu, Shaodong Dai and Gongyi Zhang
Nature 423, 49–56
(1 May 2003); doi:10.1038/nature01543
| Summary | Full Text (HTML / PDF) |
letter
EGFR activation coupled to inhibition of tyrosine phosphatases causes lateral signal propagation
Andrew R. Reynolds, Christian Tischer, Peter J. Verveer, Oliver Rocks and Philippe I. H. Bastiaens
Nature Cell Biology 5, 447–453
(May 2003); doi:10.1038/ncb981
| First Paragraph | Full Text (HTML/PDF) |
letter
Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation
Kaisa Haglund, Sara Sigismund, Simona Polo, Iwona Szymkiewicz, Pier Paolo Di Fiore and Ivan Dikic
Nature Cell Biology 5, 461–466
(May 2003); doi:10.1038/ncb983
| First Paragraph | Full Text (HTML/PDF) |
news and views
Small changes in Wnt signalling
Sarah Greaves
Nature Cell Biology 5, 387
(May 2003); doi:10.1038/ncb0503-387
| Full Text (HTML/PDF) |
review article
Nuclear lipid signalling
Robin F. Irvine
Nature Reviews Molecular Cell Biology 4, 349–361
(May 2003); doi:10.1038/nrm1100
| Summary | Full Text (HTML / PDF) |
article
IKK and TBK1 are essential components of the IRF3 signaling pathway
Katherine A. Fitzgerald, Sarah M. McWhirter, Kerrie L. Faia, Daniel C. Rowe, Eicke Latz, Douglas T. Golenbock, Anthony J. Coyle, Sha-Mei Liao and Tom Maniatis
Nature Immunology 4, 491–496
(May 2003); doi:10.1038/ni921
| Abstract | Full Text (HTML/PDF) |
news and views
Linking Toll-like receptors to IFN-a/b expression
Gregory M. Barton and Ruslan Medzhitov
Nature Immunology 4, 432–433
(May 2003); doi:10.1038/ni0503-432
| Full Text (HTML/PDF) |
review article
Cell death and immunity: The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal
Judy Lieberman
Nature Reviews Immunology 3, 361–370
(May 2003); doi:10.1038/nri1083
| Summary | Full Text (HTML / PDF) |
article
Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity
Omid Akbari, Philippe Stock, Everett Meyer, Mitchell Kronenberg, Stephane Sidobre, Toshinori Nakayama, Masaru Taniguchi, Michael J. Grusby, Rosemarie H. DeKruyff and Dale T. Umetsu
Nature Medicine 9, 582–588
(May 2003); doi:10.1038/nm851
| Abstract | Full Text (HTML/PDF) |
article
The two faces of IKK and NF-kB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion
Lee-Wei Chen, Laurence Egan, Zhi-Wei Li, Florian R. Greten, Martin F. Kagnoff and Michael Karin
Nature Medicine 9, 575–581
(May 2003); doi:10.1038/nm849
| Abstract | Full Text (HTML/PDF) |
review article
Cancer and ageing: rival demons?
Judith Campisi
Nature Reviews Cancer 3, 339–349
(May 2003); doi:10.1038/nrc1073
| Summary | Full Text (HTML / PDF) |
letter
Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia
Pamela M. Pollock, Karine Cohen-Solal, Raman Sood, Jin Namkoong, Jeffrey J. Martino, Aruna Koganti, Hua Zhu, Christiane Robbins, Izabela Makalowska, Seung-Shick Shin, Yari Marin, Kathleen G. Roberts, Laura M. Yudt, Amy Chen, Jun Cheng, Arturo Incao, Heather W. Pinkett, Christopher L Graham, Karen Dunn, Steven M. Crespo-Carbone, Kerine R. Mackason, Kevin B. Ryan, Daniel Sinsimer, James Goydos, Kenneth R. Reuhl, Michael Eckhaus, Paul S. Meltzer, William J. Pavan, Jeffrey M. Trent and Suzie Chen
Nature Genetics 34, 108–112
(May 2003); doi:10.1038/ng1148
| First Paragraph | Full Text (HTML/PDF) |
letter
Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease
Paolo A. Hernandez, Robert J. Gorlin, John N. Lukens, Shoichiro Taniuchi, Joze Bohinjec, Fleur Francois, Mary E. Klotman and George A. Diaz
Nature Genetics 34, 70–74
(May 2003); doi:10.1038/ng1149
| First Paragraph | Full Text (HTML/PDF) |
http://npg.natureny.com/__chars/epsilon/black/med/base/glyph.gif
article
A PKC -ENH-channel complex specifically modulates N-type Ca2+ channels
Yuka Maeno-Hikichi, Shaohua Chang, Kiyoyuki Matsumura, Meizan Lai, Hong Lin, Noritaka Nakagawa, Shun'ichi Kuroda and Ji-fang Zhang
Nature Neuroscience 6, 468–475
(May 2003); doi:10.1038/nn1041
| Abstract | Full Text (HTML/PDF) |
article
GABA uptake regulates cortical excitability via cell type-specific tonic inhibition
Alexey Semyanov, Matthew C. Walker and Dimitri M. Kullmann
Nature Neuroscience 6, 484–490
(May 2003); doi:10.1038/nn1043
| Abstract | Full Text (HTML/PDF) |
review article
Targeting programmed cell death in neurodegenerative diseases
Miquel Vila & Serge Przedborski
Nature Reviews Neuroscience 4, 365–375
(May 2003); doi:10.1038/nrn1100
| Summary | Full Text (HTML / PDF) |
research article
Modified apoptotic molecule (BID) reduces hepatitis C virus infection in mice with chimeric human livers
Eric C. Hsu, Belinda Hsi, Masami Hirota-Tsuchihara, Jurgen Ruland, Cathy Iorio, Farida Sarangi, Jingyu Diao, Giovanni Migliaccio, D. Lorne Tyrrell, Norman Kneteman and Christopher D. Richardson
Nature Biotechnology 21, 519–525
(May 2003); doi:10.1038/nbt817
| Abstract | Full Text (HTML/PDF) |
original paper
v-Jun stimulates both cdk2 kinase activity and G1/S progression via transcriptional repression of p21 CIP1
A Maclaren, W Clark, E J Black, D Gregory, H Fujii and D A F Gillespie
Oncogene 22, 2383–2395
(May 2003); doi:10.1038/sj.onc.1206329
| Abstract | Full Text (HTML/PDF) |
|
