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The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.
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article
An atypical haem in the cytochrome b6f complex
David Stroebel, Yves Choquet, Jean-Luc Popot and Daniel Picot
Nature 426, 413–418
(27 November 2003); doi:10.1038/nature02155
| Abstract | Full Text (HTML / PDF) |
news and views
Structural biology: Dual approach to a light problem
Werner Kühlbrandt
Nature 426, 399–400
(27 November 2003); doi:10.1038/426399a
| Full Text (HTML / PDF) |
letters to nature
An ancient role for nuclear β-catenin in the evolution of axial polarity and germ layer segregation
Athula H. Wikramanayake, Melanie Hong, Patricia N. Lee, Kevin Pang, Christine A. Byrum, Joanna M. Bince, Ronghui Xu and Mark Q. Martindale
Nature 426, 446–450
(27 November 2003); doi:10.1038/nature02113
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus
Wenhui Li, Michael J. Moore, Natalya Vasilieva, Jianhua Sui, Swee Kee Wong, Michael A. Berne, Mohan Somasundaran, John L. Sullivan, Katherine Luzuriaga, Thomas C. Greenough, Hyeryun Choe & Michael Farzan
Nature 426, 450–454
(27 November 2003); doi:10.1038/nature02145
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letters to nature
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
Noriko Sakaguchi, Takeshi Takahashi, Hiroshi Hata, Takashi Nomura, Tomoyuki Tagami, Sayuri Yamazaki, Toshiko Sakihama, Takaji Matsutani, Izumi Negishi, Syuichi Nakatsuru & Shimon Sakaguchi
Nature 426, 454–460
(27 November 2003); doi:10.1038/nature02119
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letters to nature
A positive-feedback-based bistable 'memory module' that governs a cell fate decision
Wen Xiong and James E. Ferrell Jr
Nature 426, 460–465
(27 November 2003); doi:10.1038/nature02089
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news and views
Cell biology: Thanks for the memory
Jill C. Sible
Nature 426, 392–393
(November 2003); doi:10.1038/426392a
| Full Text (HTML/PDF) |
letter
EB1 reveals mobile microtubule nucleation sites in Arabidopsis
Jordi Chan, Grant M. Calder, John H. Doonan and Clive W. Lloyd
Nature Cell Biology 5, 967–971
(November 2003); doi:10.1038/ncb1057
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news and views
Plant microtubule nucleation sites: moving right along
Sue Wick
Nature Cell Biology 5, 954
(November 2003); doi:10.1038/ncb1103-954
| Full Text (HTML/PDF) |
letter
The large Maf factor Traffic Jam controls gonad morphogenesis in Drosophila
Michelle A. Li, Jeffrey D. Alls, Rita M. Avancini, Karen Koo and Dorothea Godt
Nature Cell Biology 5, 994–1000
(November 2003); doi:10.1038/ncb1058
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news and views
Stuck without Traffic Jam
Helen McNeill
Nature Cell Biology 5, 948–949
(November 2003); doi:10.1038/ncb1103-948
| Full Text (HTML/PDF) |
perspectives
Timeline: Dorothy Hodgkin and her contributions to biochemistry
Judith A. K. Howard
Nature Reviews Molecular Cell Biology 4, 891–896
(November 2003); doi:10.1038/nrm1243
| Abstract | Full Text (HTML / PDF) |
article
Leukocyte functional antigen 1 lowers T cell activation thresholds and signaling through cytohesin-1 and Jun-activating binding protein 1
Omar D Perez, Dennis Mitchell, Gina C Jager, Sharon South, Chris Murriel, Jacqueline McBride, Lee A Herzenberg, Shigemi Kinoshita and Garry P Nolan
Nature Immunology 4, 1083–1092
(November 2003); doi:10.1038/ni984
| Abstract | Full Text (HTML/PDF) |
news and views
LFA-1: more than just T cell Velcro
Yoji Shimizu
Nature Immunology 4, 1052–1054
(November 2003); doi:10.1038/ni1103-1052
| Full Text (HTML/PDF) |
article
Adaptor protein 3-dependent microtubule-mediated movement of lytic granules to the immunological synapse
Richard H Clark, Jane C Stinchcombe, Anna Day, Emma Blott, Sarah Booth, Giovanna Bossi, Terry Hamblin, E Graham Davies and Gillian M Griffiths
Nature Immunology 4, 1111–1120
(November 2003); doi:10.1038/ni1000
| Abstract | Full Text (HTML/PDF) |
news and views
The latest killer AP
Margarita Del Val and Jonathan W Yewdell
Nature Immunology 4, 1049–1050
(November 2003); doi:10.1038/ni1103-1049
| Full Text (HTML/PDF) |
article
Inositol 1,3,4,5-tetrakisphosphate is essential for T lymphocyte development
Valérie Pouillon, Romana Hascakova-Bartova, Bernard Pajak, Emmanuelle Adam, Françoise Bex, Valérie Dewaste, Carine Van Lint, Oberdan Leo, Christophe Erneux and Stéphane Schurmans
Nature Immunology 4, 1136–1143
(November 2003); doi:10.1038/ni980
| Abstract | Full Text (HTML/PDF) |
review article
Ocular immune privilege: therapeutic opportunities from an experiment of nature
J. Wayne Streilein
Nature Reviews Immunology 3, 879–889
(November 2003); doi:10.1038/nri1224
| Abstract | Full Text (HTML / PDF) |
article
Ex vivo identification, isolation and analysis of tumor-cytolytic T cells
Valerie Rubio, Tor B Stuge, Naileshni Singh, Michael R Betts, Jeffrey S Weber, Mario Roederer and Peter P Lee
Nature Medicine 9, 1377–1382
(November 2003); doi:10.1038/nm942
| Abstract | Full Text (HTML/PDF) |
letter
PML-RARA-targeted DNA vaccine induces protective immunity in a mouse model of leukemia
Rose Ann Padua, Jerome Larghero, Marie Robin, Carol le Pogam, Marie-Helene Schlageter, Sacha Muszlak, Jan Fric, Robert West, Philippe Rousselot, Thi Hai Phan, Liesbeth Mudde, Helene Teisserenc, Antoine F Carpentier, Scott Kogan, Laurent Degos, Marika Pla, J Michael Bishop, Freda Stevenson, Dominique Charron and Christine Chomienne
Nature Medicine 9, 1413–1417
(November 2003); doi:10.1038/nm949
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news and views
Cancer vaccine targets leukemia
John Donnelly
Nature Medicine 9, 1354–1356
(November 2003); doi:10.1038/nm1103-1354
| Full Text (HTML/PDF) |
letter
G13 is an essential mediator of platelet activation in hemostasis and thrombosis
Alexandra Moers, Bernhard Nieswandt, Steffen Massberg, Nina Wettschureck, Sabine Grüner, Ildiko Konrad, Valerie Schulte, Barsom Aktas, Marie-Pierre Gratacap, Melvin I Simon, Meinrad Gawaz and Stefan Offermanns
Nature Medicine 9, 1418–1422
(November 2003); doi:10.1038/nm943
| First Paragraph | Full Text (HTML/PDF) |
news and views
A TUG on glucose transport
Alan R Saltiel
Nature Medicine 9, 1352
(November 2003); doi:10.1038/nm1103-1352
| Full Text (HTML/PDF) |
review article
AP-1: a double-edged sword in tumorigenesis
Robert Eferl and Erwin F. Wagner
Nature Reviews Cancer 3, 859–868
(November 2003); doi:10.1038/nrc1209
| Abstract | Full Text (HTML / PDF) |
technical report
DNA helicase gene interaction network defined using synthetic lethality analyzed by microarray
Siew Loon Ooi, Daniel D Shoemaker and Jef D Boeke
Nature Genetics 35, 277–286
(November 2003); doi:10.1038/ng1258
| Abstract | Full Text (HTML/PDF) |
news and views
Lethal combinations
Chandra L Tucker and Stanley Fields
Nature Genetics 35, 204–205
(November 2003); doi:10.1038/ng1103-204
| Full Text (HTML/PDF) |
review article
The genetic and molecular basis of congenital eye defects
Jochen Graw
Nature Reviews Genetics 4, 876–888
(November 2003); doi:10.1038/nrg1202
| Abstract | Full Text (HTML / PDF) |
brief communication
Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis
David Engblom, Sipra Saha, Linda Engström, Marie Westman, Laurent P Audoly, Per-Johan Jakobsson and Anders Blomqvist
Nature Neuroscience 6, 1137–1138
(November 2003); doi:10.1038/nn1137
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article
Vertebrate neurogenesis is counteracted by Sox1-3 activity
Magdalena Bylund, Elisabeth Andersson, Bennett G Novitch and Jonas Muhr
Nature Neuroscience 6, 1162–1168
(November 2003); doi:10.1038/nn1131
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news and views
Pulling the Soxs off proliferation
Kalyani Narasimhan
Nature Neuroscience 6, 1125
(November 2003); doi:10.1038/nn1103-1125
| Full Text (HTML/PDF) |
article
β-catenin is critical for dendritic morphogenesis
Xiang Yu and Robert C Malenka
Nature Neuroscience 6, 1169–1177
(November 2003); doi:10.1038/nn1132
| Abstract | Full Text (HTML/PDF) |
review article
Axon guidance mechanisms and molecules: lessons from invertebrates
Sofia J. Araújo and Guy Tear
Nature Reviews Neuroscience 4, 910–922
(November 2003); doi:10.1038/nrn1243
| Abstract | Full Text (HTML / PDF) |
letter
Computational discovery of gene modules and regulatory networks
Ziv Bar-Joseph, Georg K Gerber, Tong Ihn Lee, Nicola J Rinaldi, Jane Y Yoo, François Robert, D Benjamin Gordon, Ernest Fraenke, Tommi S Jaakkola, Richard A Young, & David K Gifford
Nature Biotechnology 21,1337–1342
(November 2003); doi:10.1038/nbt890
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letter
Reconstructing genetic networks in yeast
Zhaolei Zhang & Mark Gerstein
Nature Biotechnology 21,1295–1297
(November 2003); doi:10.1038/nbt1103-1295
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article
The structure and binding mode of interleukin-18
Zenichiro Kato, JunGoo Jee, Hiroaki Shikano, Masaki Mishima, Izuru Ohki, Hidenori Ohnishi, Ailian Li, Kazuyuki Hashimoto, Eiji Matsukuma, Kentaro Omoya, Yutaka Yamamoto, Teruyo Yoneda, Takane Hara, Naomi Kondo & Masahiro Shirakawa
Nature Structural Biology 10, 966–971
(November 2003); doi:10.1038/nsb993
| Abstract | Full Text (HTML / PDF) |
article
Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis
Xue Li, Kenneth A. Oghi, Jie Zhang, Anna Krones, Kevin T. Bush, Christopher K. Glass, Sanjay K. Nigam, Aneel K. Aggarwal, Richard Maas, David W. Rose and Michael G. Rosenfeld
Nature 426, 247–254
(20 November 2003); doi:10.1038/nature02083
| Abstract | Full Text (HTML / PDF) |
letters to nature
Eyes absent represents a class of protein tyrosine phosphatases
Jayanagendra P. Rayapureddi, Chandramohan Kattamuri, Brian D. Steinmetz, Benjamin J. Frankfort, Edwin J. Ostrin, Graeme Mardon and Rashmi S. Hegde
Nature 426, 295–298
(20 November 2003); doi:10.1038/nature02093
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letters to nature
The transcription factor Eyes absent is a protein tyrosine phosphatase
Tina L. Tootle , Serena J. Silver , Erin L. Davies , Victoria Newman, Robert R. Latek, Ishara A. Mills, Jeremy D. Selengut, Beth E. W. Parlikar and Ilaria Rebay
Nature 426, 299–302
(20 November 2003); doi:10.1038/nature02097
| First Paragraph | Full Text (HTML / PDF) |
news and views
Signal transduction: An eye on organ development
Jonathan A. Epstein and Benjamin G. Neel
Nature 426, 238–239
(20 November 2003); doi:10.1038/426238a
| Full Text (HTML / PDF) |
article
Regulation of phyllotaxis by polar auxin transport
Didier Reinhardt, Eva-Rachele Pesce, Pia Stieger, Therese Mandel, Kurt Baltensperger, Malcolm Bennett, Jan Traas, Jirí Friml and Cris Kuhlemeier
Nature 426, 255–260
(20 November 2003); doi:10.1038/nature02081
| Abstract | Full Text (HTML / PDF) |
news and views
Plant development: Leaves by number
Christopher Surridge
Nature 426, 237
(20 November 2003); doi:10.1038/426237a
| Full Text (HTML / PDF) |
letters to nature
Activation of the TRPC1 cation channel by metabotropic glutamate receptor mGluR1
Sang Jeong Kim, Yu Shin Kim, Joseph P. Yuan, Ronald S. Petralia, Paul F. Worley and David J. Linden
Nature 426, 285–291
(20 November 2003); doi:10.1038/nature02162
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letters to nature
Testis determination requires insulin receptor family function in mice
Serge Nef , Sunita Verma-Kurvari, Jussi Merenmies, Jean-Dominique Vassalli, Argiris Efstratiadis, Domenico Accili and Luis F. Parada
Nature 426, 291–295
(20 November 2003); doi:10.1038/nature02059
| First Paragraph | Full Text (HTML / PDF) |
news and views
Developmental biology: Gender benders
Peter Koopman
Nature 426, 241
(20 November 2003); doi:10.1038/426241a
| Full Text (HTML / PDF) |
letters to nature
FKF1 is essential for photoperiodic-specific light signalling in Arabidopsis
Takato Imaizumi, Hien G. Tran, Trevor E. Swartz, Winslow R. Briggs and Steve A. Kay
Nature 426, 302–306
(20 November 2003); doi:10.1038/nature02090
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letter
Actin filament uncapping localizes to ruffling lamellae and rocketing vesicles
Philip G. Allen
Nature Cell Biology 5, 972–979
(November 2003); doi:10.1038/ncb1059
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letter
Discs-Large and Strabismus are functionally linked to plasma membrane formation
Ok-Kyung Lee, Kristopher K. Frese, Jennifer S. James, Darshana Chadda, Zhi-Hong Chen, Ronald T. Javier and Kyung-Ok Cho
Nature Cell Biology 5, 987–993
(November 2003); doi:10.1038/ncb1055
| First Paragraph | Full Text (HTML/PDF) |
letter
Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases
Manabu Furukawa, Yizhou Joseph He, Christoph Borchers and Yue Xiong
Nature Cell Biology 5, 1001–1007
(November 2003); doi:10.1038/ncb1056
| First Paragraph | Full Text (HTML/PDF) |
news and views
BTB proteins as henchmen of Cul3-based ubiquitin ligases
Wilhelm Krek
Nature Cell Biology 5, 950–951
(November 2003); doi:10.1038/ncb1103-950
| Full Text (HTML/PDF) |
review article
Some assembly required: the development of neuronal synapses
Zheng Li and Morgan Sheng
Nature Reviews Molecular Cell Biology 4, 833–841
(November 2003); doi:10.1038/nrm1242
| Abstract | Full Text (HTML / PDF) |
article
Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance
Alberto Sánchez-Fueyo, Jane Tian, Dominic Picarella, Christoph Domenig, Xin Xiao Zheng, Catherine A. Sabatos, Natasha Manlongat, Orissa Bender, Thomas Kamradt, Vijay K. Kuchroo, José-Carlos Gutiérrez-Ramos, Anthony J. Coyle and Terry B. Strom
Nature Immunology 4, 1093–1101
(November 2003); doi:10.1038/ni987
| Abstract | Full Text (HTML/PDF) |
article
Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance
Catherine A Sabatos, Sumone Chakravarti, Eugene Cha, Anna Schubart, Alberto Sánchez-Fueyo, Xin Xiao Zheng, Anthony J. Coyle, Terry B. Strom, Gordon J. Freeman and Vijay K. Kuchroo
Nature Immunology 4, 1102–1110
(November 2003); doi:10.1038/ni988
| Abstract | Full Text (HTML/PDF) |
news and views
I-Tim-izing the pathways of counter-regulation
Marsha Wills-Karp, Yasmine Belkaid and Christopher L. Karp
Nature Immunology 4, 1050–1052
(November 2003); doi:10.1038/ni1103-1050
| Full Text (HTML/PDF) |
article
Lymphotoxin pathway directs thymic Aire expression
Robert K. Chin, James C. Lo, Oliver Kim, Sarah E. Blink, Peter A. Christiansen, Pärt Peterson, Yang Wang, Carl Ware and Yang-Xin Fu
Nature Immunology 4, 1121–1127
(November 2003); doi:10.1038/ni982
| Abstract | Full Text (HTML/PDF) |
article
A domain of Foxn1 required for crosstalk-dependent thymic epithelial cell differentiation
Dong-ming Su, Samuel Navarre, Won-jong Oh, Brian G. Condie and Nancy R. Manley
Nature Immunology 4, 1128–1135
(November 2003); doi:10.1038/ni983
| Abstract | Full Text (HTML/PDF) |
review article
Cell migration and the control of post-natal T-cell lymphopoiesis in the thymus
Howard T. Petrie
Nature Reviews Immunology 3, 859–866
(November 2003); doi:10.1038/nri1223
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article
Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells
Alexandra Aicher, Christopher Heeschen, Christiane Mildner-Rihm, Carmen Urbich, Christian Ihling, Katja Technau-Ihling, Andreas M. Zeiher and Stefanie Dimmeler
Nature Medicine 9, 1370–1376
(November 2003); doi:10.1038/nm948
| Abstract | Full Text (HTML/PDF) |
article
HIV-1 Vif protein binds the editing enzyme APOBEC3G and induces its degradation
Mariana Marin, Kristine M. Rose, Susan L. Kozak and David Kabat
Nature Medicine 9, 1398–1403
(November 2003); doi:10.1038/nm946
| Abstract | Full Text (HTML/PDF) |
letter
The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif
Ann M. Sheehy, Nathan C. Gaddis and Michael H. Malim
Nature Medicine 9, 1404–1407
(November 2003); doi:10.1038/nm945
| First Paragraph | Full Text (HTML/PDF) |
news and views
Muscles flex, axons die
Jean R. Wrathall
Nature Medicine 9, 1347–1348
(November 2003); doi:10.1038/nm1103-1347
| Full Text (HTML/PDF) |
news and views
Tinged migration
Charlotte Schubert
Nature Medicine 9, 1355
(November 2003); doi:10.1038/nm1103-1355
| Full Text (HTML/PDF) |
review article
Aromatase inhibitors for breast cancer: lessons from the laboratory
Stephen R.D. Johnston and Mitch Dowsett
Nature Reviews Cancer 3, 821–831
(November 2003); doi:10.1038/nrc1211
| Abstract | Full Text (HTML / PDF) |
letter
Interaction of reelin signaling and Lis1 in brain development
Amir H. Assadi, Guangcheng Zhang, Uwe Beffert, Robert S. McNeil, Amy L. Renfro, Sanyong Niu, Carlo C. Quattrocchi, Barbara A. Antalffy, Michael Sheldon, Dawna D. Armstrong, Anthony Wynshaw-Boris, Joachim Herz, Gabriella D'Arcangelo and Gary D. Clark
Nature Genetics 35, 270–276
(November 2003); doi:10.1038/ng1257
| First Paragraph | Full Text (HTML/PDF) |
letter
Positional cloning of a novel gene influencing asthma from Chromosome 2q14
Maxine Allen, Andrea Heinzmann, Emiko Noguchi, Gonçalo Abecasis, John Broxholme, Chris P. Ponting, Sumit Bhattacharyya, Jon Tinsley, Youming Zhang, Richard Holt, E. Yvonne Jones, Nick Lench, Alisoun Carey, Helene Jones, Nicholas J. Dickens, Claire Dimon, Rosie Nicholls, Crystal Baker, Luzheng Xue, Elizabeth Townsend, Michael Kabesch, Stephan K. Weiland, David Carr, Erika von Mutius, Ian M. Adcock, Peter J. Barnes, G. Mark Lathrop, Mark Edwards, Miriam F. Moffatt and William O. C. M. Cookson
Nature Genetics 35, 258–263
(November 2003); doi:10.1038/ng1256
| First Paragraph | Full Text (HTML/PDF) |
article
Inhibition of Caenorhabditis elegans social feeding by FMRFamide-related peptide activation of NPR-1
Candida Rogers, Vincenzina Reale, Kyuhyung Kim, Heather Chatwin, Chris Li, Peter Evans and Mario de Bono
Nature Neuroscience 6, 1178–1185
(November 2003); doi:10.1038/nn1140
| Abstract | Full Text (HTML/PDF) |
news and views
Food for thought: a receptor finds its ligand
Christopher J. Potter and Liqun Luo
Nature Neuroscience 6, 1119–1120
(November 2003); doi:10.1038/nn1103-1119
| Full Text (HTML/PDF) |
article
Activity-induced targeting of profilin and stabilization of dendritic spine morphology
Manuel Ackermann and Andrew Matus
Nature Neuroscience 6, 1194–1200
(November 2003); doi:10.1038/nn1135
| Abstract | Full Text (HTML/PDF) |
article
Regulation of gene expression and cocaine reward by CREB and ΔFosB
Colleen A. McClung and Eric J. Nestler
Nature Neuroscience 6, 1208–1215
(November 2003); doi:10.1038/nn1143
| Abstract | Full Text (HTML/PDF) |
article
Targeting cytokines to inflammation sites
Gill Adams, Sandrine Vessillier, Hanna Dreja and Yuti Chernajovsky
Nature Biotechnology 21, 1314–1320
(November 2003); doi:10.1038/nbt888
| Abstract | Full Text (HTML/PDF) |
news and views
Engineering better cytokines
Lawrence Steinman
Nature Biotechnology 21, 1293–1294
(November 2003); doi:10.1038/nbt1103-1293
| Abstract | Full Text (HTML/PDF) |
review article
Targeting the Nogo Receptor to Treat Central Nervous System Injuries
Daniel H. S. Lee, Stephen M. Strittmatter and Dinah W. Y. Sah
Nature Reviews Drug Discovery 2, 872–879
(November 2003); doi:10.1038/nrd1228
| Abstract | Full Text (HTML / PDF) |
article
Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination
Jijie Chai, Nieng Yan, Jun R. Huh, Jia-Wei Wu, Wenyu Li, Bruce A. Hay and Yigong Shi
Nature Structural Biology 10, 892–898
(November 2003); doi:10.1038/nsb989
| Abstract | Full Text (HTML/PDF) |
article
Tandem PDZ repeats in glutamate receptor-interacting proteins have a novel mode of PDZ domain-mediated target binding
Wei Feng, Yawei Shi, Ming Li and Mingjie Zhang
Nature Structural Biology 10, 972–978
(November 2003); doi:10.1038/nsb992
| Abstract | Full Text (HTML/PDF) |
article
Efflux-dependent auxin gradients establish the apical-basal axis of Arabidopsis
Jirí Friml, Anne Vieten, Michael Sauer, Dolf Weijers, Heinz Schwarz, Thorsten Hamann, Remko Offringa and Gerd Jürgens
Nature 426, 147–153
(13 November 2003); doi:10.1038/nature02085
| Abstract | Full Text (HTML / PDF) |
news and views
Plant development: An axis of auxin
Stefan Kepinski and Ottoline Leyser
Nature 426, 132–135
(13 November 2003); doi:10.1038/426132b
| Full Text (HTML / PDF) |
letters to nature
APL regulates vascular tissue identity in Arabidopsis
Martin Bonke, Siripong Thitamadee, Ari Pekka Mähönen, Marie-Theres Hauser and Ykä Helariutta
Nature 426, 181–186
(13 November 2003); doi:10.1038/nature02100
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-γ
Stephan Herzig, Susan Hedrick, Ianessa Morantte, Seung-Hoi Koo, Francesco Galimi and Marc Montminy
Nature 426, 190–193
(13 November 2003); doi:10.1038/nature02110
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
A DNA damage checkpoint response in telomere-initiated senescence
Fabrizio d'Adda di Fagagna, Philip M. Reaper, Lorena Clay-Farrace, Heike Fiegler, Philippa Carr, Thomas von Zglinicki, Gabriele Saretzki, Nigel P. Carter and Stephen P. Jackson
Nature 426, 194–198
(13 November 2003); doi:10.1038/nature02118
| First Paragraph | Full Text (HTML / PDF) |
letter
Load-dependent kinetics of force production by smooth muscle myosin measured with optical tweezers
Claudia Veigel, Justin E. Molloy, Stephan Schmitz and John Kendrick-Jones
Nature Cell Biology 5, 980–986
(November 2003); doi:10.1038/ncb1060
| First Paragraph | Full Text (HTML/PDF) |
letter
Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint
Leigh Ann A. Higa, Ivailo S. Mihaylov, Damon P. Banks, Jianyu Zheng and Hui Zhang
Nature Cell Biology 5, 1008–1015
(November 2003); doi:10.1038/ncb1061
| First Paragraph | Full Text (HTML/PDF) |
news and views
The kinetochore NUPtials
P. Todd Stukenberg and Ian G. Macara
Nature Cell Biology 5, 945–947
(November 2003); doi:10.1038/ncb1103-945
| Full Text (HTML/PDF) |
review article
Ratchets and clocks: the cell cycle, ubiquitylation and protein turnover
Steven I. Reed
Nature Reviews Molecular Cell Biology 4, 855–864
(November 2003); doi:10.1038/nrm1246
| Abstract | Full Text (HTML / PDF) |
article
Control of dendritic cell cross-presentation by the major histocompatibility complex class I cytoplasmic domain
Gregory Lizée, Genc Basha, Jacqueline Tiong, Jean-Pierre Julien, Meimei Tian, Kaan E Biron and Wilfred A Jefferies
Nature Immunology 4, 1065–1073
(November 2003); doi:10.1038/ni989
| Abstract | Full Text (HTML/PDF) |
news and views
Y in X priming
Sebastian Amigorena
Nature Immunology 4, 1047–1048
(November 2003); doi:10.1038/ni1103-1047
| Full Text (HTML/PDF) |
review article
Scaffolding of antigen receptors for immunogenic versus tolerogenic signaling
Jesse E Jun and Christopher C Goodnow
Nature Immunology 4, 1057–1064
(November 2003); doi:10.1038/ni1001
| Abstract | Full Text (HTML/PDF) |
article
An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice
Jayakrishna Ambati, Akshay Anand, Stefan Fernandez, Eiji Sakurai, Bert C Lynn, William A Kuziel, Barrett J Rollins and Balamurali K Ambati
Nature Medicine 9, 1390–1397
(November 2003); doi:10.1038/nm950
| Abstract | Full Text (HTML/PDF) |
news and views
Macrophages eyed in macular degeneration
J V Forrester
Nature Medicine 9, 1350–1351
(November 2003); doi:10.1038/nm1103-1350
| Full Text (HTML/PDF) |
review article
Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer
Peter M. Siegel and Joan Massagué
Nature Reviews Cancer 3, 807–820
(November 2003); doi:10.1038/nrc1208
| Abstract | Full Text (HTML / PDF) |
article
Tat-binding protein-1, a component of the 26S proteasome, contributes to the E3 ubiquitin ligase function of the von Hippel-Lindau protein
Paul G Corn, E Robert McDonald III, James G Herman and Wafik S El-Deiry
Nature Genetics 35, 229–237
(November 2003); doi:10.1038/ng1254
| Abstract | Full Text (HTML/PDF) |
letter
Loss of collagenase-2 confers increased skin tumor susceptibility to male mice
Milagros Balbín, Antonio Fueyo, Angus M Tester, Alberto M Pendás, Ana S Pitiot, Aurora Astudillo, Christopher M Overall, Steven D Shapiro and Carlos López-Otín
Nature Genetics 35, 252–257
(November 2003); doi:10.1038/ng1249
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article
EXP-1 is an excitatory GABA-gated cation channel
Asim A Beg and Erik M Jorgensen
Nature Neuroscience 6, 1145–1152
(November 2003); doi:10.1038/nn1136
| Abstract | Full Text (HTML/PDF) |
news and views
Exciting guts with GABA
Jean-Marc Goaillard and Eve Marder
Nature Neuroscience 6, 1121–1122
(November 2003); doi:10.1038/nn1103-1121
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review article
The molecular logic of endocannabinoid signalling
Daniele Piomelli
Nature Reviews Neuroscience 4, 873–884
(November 2003); doi:10.1038/nrn1247
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article
A genetic approach to inactivating chemokine receptors using a modified viral protein
V McNeil Coffield, Qi Jiang & Lishan Su
Nature Biotechnology 21,1321–1327
( 2000); doi:10.1038/nbt889
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article
Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation
Bin Y Qin, Cheng Liu, Suvana S Lam, Hema Srinath, Rachel Delston, John J Correia, Rik Derynck and Kai Lin
Nature Structural Biology 10, 913–921
(November 2003); doi:10.1038/nsb1002
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article
X-ray crystal structure of IRF-3 and its functional implications
Kiyohiro Takahasi, Nobuo N Suzuki, Masataka Horiuchi, Mitsuaki Mori, Wakako Suhara, Yasutaka Okabe, Yukiko Fukuhara, Hiroaki Terasawa, Shizuo Akira, Takashi Fujita and Fuyuhiko Inagaki
Nature Structural Biology 10, 922–927
(November 2003); doi:10.1038/nsb1001
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news and views
The nuts and bolts of IRF structure
Aristidis Moustakas and Carl-Henrik Heldin
Nature Structural Biology 10, 874–876
(November 2003); doi:10.1038/nsb1103-874
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article
Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside
Eva Pebay-Peyroula, Cécile Dahout-Gonzalez, Richard Kahn, Véronique Trézéguet, Guy J.-M. Lauquin and Gérard Brandolin
Nature 426, 39–44
(06 November 2003); doi:10.1038/nature02056
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letters to nature
Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells
Christine R. Rose, Robert Blum, Bruno Pichler, Alexandra Lepier, Karl W. Kafitz and Arthur Konnerth
Nature 426, 74–78
(06 November 2003); doi:10.1038/nature01983
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news and views
Neurobiology: Signals that make waves
Louis F. Reichardt
Nature 426, 25–26
(06 November 2003); doi:10.1038/426025a
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letters to nature
Methylation at lysine 4 of histone H3 in ecdysone-dependent development of Drosophila
Yurii Sedkov, Elizabeth Cho, Svetlana Petruk, Lucy Cherbas, Sheryl T. Smith, Richard S. Jones, Peter Cherbas, Eli Canaani, James B. Jaynes and Alexander Mazo
Nature 426, 78–83
(06 November 2003); doi:10.1038/nature02080
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letters to nature
Hedgehog signalling in the mouse requires intraflagellar transport proteins
Danwei Huangfu, Aimin Liu, Andrew S. Rakeman, Noel S. Murcia, Lee Niswander and Kathryn V. Anderson
Nature 426, 83–87
(06 November 2003); doi:10.1038/nature02061
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letters to nature
Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage
Luca Busino, Maddalena Donzelli, Massimo Chiesa, Daniele Guardavaccaro, Dvora Ganoth, N. Valerio Dorrello, Avram Hershko, Michele Pagano and Giulio F. Draetta
Nature 426, 87–91
(06 November 2003); doi:10.1038/nature02082
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letters to nature
Structural adaptability in the ligand-binding pocket of the ecdysone hormone receptor
Isabelle M. L. Billas, Thomas Iwema, Jean-Marie Garnier, André Mitschler, Natacha Rochel and Dino Moras
Nature 426, 91–96
(06 November 2003); doi:10.1038/nature02112
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news and views
Microbiology: Destructive approach
Amanda Tromans
Nature 426, 23
(06 November 2003); doi:10.1038/426023a
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news and views
Cell biology: Enlightened messages
Clare Thomas
Nature 426, 27
(06 November 2003); doi:10.1038/426027a
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review article
The immune response of Drosophila
Jules A. Hoffmann
Nature 426, 33–38
(06 November 2003); doi:10.1038/nature02021
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letter
Production of PtdInsP3 at endomembranes is triggered by receptor endocytosis
Moritoshi Sato, Yoshibumi Ueda, Tokio Takagi and Yoshio Umezawa
Nature Cell Biology 5, 1016–1022
(November 2003); doi:10.1038/ncb1054
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brief communication
Homologue disjunction in mouse oocytes requires proteolysis of securin and cyclin B1
Mary Herbert, Mark Levasseur, Hayden Homer, Katie Yallop, Alison Murdoch and Alex McDougall
Nature Cell Biology 5, 1023–1025
(November 2003); doi:10.1038/ncb1062
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news and views
Three Yips for Rab recruitment
Jemima Barrowman and Peter Novick
Nature Cell Biology 5, 955–956
(November 2003); doi:10.1038/ncb1103-955
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review article
The cellular geography of Aurora kinases
Mar Carmena and William C. Earnshaw
Nature Reviews Molecular Cell Biology 4, 842–854
(November 2003); doi:10.1038/nrm1245
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article
TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway
Masahiro Yamamoto, Shintaro Sato, Hiroaki Hemmi, Satoshi Uematsu, Katsuaki Hoshino, Tsuneyasu Kaisho, Osamu Takeuchi, Kiyoshi Takeda and Shizuo Akira
Nature Immunology 4, 1144–1150
(November 2003); doi:10.1038/ni986
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article
Enhancement of CIITA transcriptional function by ubiquitin
Susanna F Greer, Eleni Zika, Brian Conti, Xin-Sheng Zhu and Jenny P-Y Ting
Nature Immunology 4, 1074–1082
(November 2003); doi:10.1038/ni985
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review article
Regulation of JAK-STAT signalling in the immune system
Ke Shuai and Bin Liu
Nature Reviews Immunology 3, 900–911
(November 2003); doi:10.1038/nri1226
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article
Hepatocyte growth factor and its receptor are required for malaria infection
Margarida Carrolo, Silvia Giordano, Laura Cabrita-Santos, Simona Corso, Ana M Vigário, Susana Silva, Patricia Leirião, Daniel Carapau, Rosario Armas-Portela, Paolo M Comoglio, Ana Rodriguez and Maria M Mota
Nature Medicine 9, 1363–1369
(November 2003); doi:10.1038/nm947
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news and views
Setting fat on fire
Robert Walczak and Peter Tontonoz
Nature Medicine 9, 1348–1349
(November 2003); doi:10.1038/nm1103-1348
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perspectives
Opinion: Merlin and ERM proteins: unappreciated roles in cancer development?
Andrea I. McClatchey
Nature Reviews Cancer 3, 877–883
(November 2003); doi:10.1038/nrc1213
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article
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation
Nobunao Wakabayashi, Ken Itoh, Junko Wakabayashi, Hozumi Motohashi, Shuhei Noda, Satoru Takahashi, Sumihisa Imakado, Tomoe Kotsuji, Fujio Otsuka, Dennis R Roop, Takanori Harada, James Douglas Engel and Masayuki Yamamoto
Nature Genetics 35, 238–245
(November 2003); doi:10.1038/ng1248
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news and views
A keaper and a striker maintain epidermal homeostasis
Thomas M Magin
Nature Genetics 35, 202–204
(November 2003); doi:10.1038/ng1103-202
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article
Disruption of ErbB receptor signaling in adult non-myelinating Schwann cells causes progressive sensory loss
Suzhen Chen, Carlos Rio, Ru-Rong Ji, Pieter Dikkes, Richard E Coggeshall, Clifford J Woolf and Gabriel Corfas
Nature Neuroscience 6, 1186–1193
(November 2003); doi:10.1038/nn1139
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article
PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis
Rong Rong, Jee-Yin Ahn, Honglian Huang, Eiichiro Nagata, Daniel Kalman, Judith A Kapp, Jiancheng Tu, Paul F Worley, Solomon H Snyder and Keqiang Ye
Nature Neuroscience 6, 1153–1161
(November 2003); doi:10.1038/nn1134
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review article
Monitoring of stored and available fuel by the CNS: implications for obesity
Randy J. Seeley and Stephen C. Woods
Nature Reviews Neuroscience 4, 901–909
(November 2003); doi:10.1038/nrn1245
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new and views
Playing tag with the yeast proteome
Brenda J Andrews, Gary D Bader & Charles Boone
Nature Biotechnology 21,1297–1299
(November 2003); doi:10.1038/nbt1103-1297
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article
Structural determinants of SecB recognition by SecA in bacterial protein translocation
Jiahai Zhou and Zhaohui Xu
Nature Structural Biology 10, 942–947
(November 2003); doi:10.1038/nsb980
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