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December 2003
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The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.
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article
Molecular machinery for non-vesicular trafficking of ceramide
Kentaro Hanada, Keigo Kumagai, Satoshi Yasuda, Yukiko Miura, Miyuki Kawano, Masayoshi Fukasawa and Masahiro Nishijima
Nature 426, 803–809
(18 December 2003); doi:10.1038/nature02188
| Abstract | Full Text (HTML / PDF) |
news and views
Cell biology: Earthworms and lipid couriers
Sean Munro
Nature 426, 775–776
(18 December 2003); doi:10.1038/426775a
| Full Text (HTML / PDF) |
letters to nature
The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes
Lakshmanan Ganesh, Ezra Burstein, Anuradha Guha-Niyogi, Mark K. Louder, John R. Mascola, Leo W. J. Klomp, Cisca Wijmenga, Colin S. Duckett and Gary J. Nabel
Nature 426, 853–857
(18 December 2003); doi:10.1038/nature02171
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Evolutionary conservation of biogenesis of β-barrel membrane proteins
Stefan A. Paschen, Thomas Waizenegger, Tincuta Stan, Marc Preuss, Marek Cyrklaff, Kai Hell, Doron Rapaport and Walter Neupert
Nature 426, 862–866
(18 December 2003); doi:10.1038/nature02208
| First Paragraph | Full Text (HTML / PDF) |
news and views
Cell cycle: Passenger acrobatics
Toru Higuchi and Frank Uhlmann
Nature 426, 780–781
(18 December 2003); doi:10.1038/426780a
| Full Text (HTML / PDF) |
letter
Citron-N is a neuronal Rho-associated protein involved in Golgi organization through actin cytoskeleton regulation
Paola Camera, Jorge Santos Da Silva, Gareth Griffiths, Maria Gabriella Giuffrida, Luciana Ferrara, Vanessa Schubert, Sara Imarisio, Lorenzo Silengo, Carlos G. Dotti and Ferdinando Di Cunto
Nature Cell Biology 5, 1071–1078
(December 2003); doi:10.1038/ncb1064
| First Paragraph | Full Text (HTML/PDF) |
letter
Mitochondrial translocation of cofilin is an early step in apoptosis induction
Boon Tin Chua, Christiane Volbracht, Kuan Onn Tan, Rong Li, Victor C. Yu and Peng Li
Nature Cell Biology 5, 1083–1089
(December 2003); doi:10.1038/ncb1070
| First Paragraph | Full Text (HTML/PDF) |
letter
RGS16 inhibits signalling through the Gα13-Rho axis
Eric N. Johnson, Tammy M. Seasholtz, Abdul A. Waheed, Barry Kreutz, Nobuchika Suzuki, Tohru Kozasa, Teresa L.Z. Jones, Joan Heller Brown and Kirk M. Druey
Nature Cell Biology 5, 1095–1103
(December 2003); doi:10.1038/ncb1065
| First Paragraph | Full Text (HTML/PDF) |
letter
Hsk1-Dfp1 is required for heterochromatin-mediated cohesion at centromeres
Julie M. Bailis, Pascal Bernard, Richard Antonelli, Robin C. Allshire and Susan L. Forsburg
Nature Cell Biology 5, 1111–1116
(December 2003); doi:10.1038/ncb1069
| First Paragraph | Full Text (HTML/PDF) |
news and views
AP-1B: polarized sorting at the endosome
Linton M. Traub and Gerard Apodaca
Nature Cell Biology 5, 1045–1047
(December 2003); doi:10.1038/ncb1203-1045
| Full Text (HTML/PDF) |
review article
Post-translational modifications regulate microtubule function
Stefan Westermann and Klaus Weber
Nature Reviews Molecular Cell Biology 4, 938–948
(December 2003); doi:10.1038/nrm1260
| Abstract | Full Text (HTML / PDF) |
article
Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
Susan M Kaech, Joyce T Tan, E John Wherry, Bogumila T Konieczny, Charles D Surh and Rafi Ahmed
Nature Immunology 4, 1191–1198
(December 2003); doi:10.1038/ni1009
| Abstract | Full Text (HTML/PDF) |
article
Modulation of tryptophan catabolism by regulatory T cells
Francesca Fallarino, Ursula Grohmann, Kwang Woo Hwang, Ciriana Orabona, Carmine Vacca, Roberta Bianchi, Maria Laura Belladonna, Maria Cristina Fioretti, Maria-Luisa Alegre and Paolo Puccetti
Nature Immunology 4, 1206–1212
(December 2003); doi:10.1038/ni1003
| Abstract | Full Text (HTML/PDF) |
article
Variable MHC class I engagement by Ly49 natural killer cell receptors demonstrated by the crystal structure of Ly49C bound to H-2Kb
Julie Dam, Rongjin Guan, Kannan Natarajan, Nazzareno Dimasi, Lukasz K Chlewicki, David M Kranz, Peter Schuck, David H Margulies and Roy A Mariuzza
Nature Immunology 4, 1213–1222
(December 2003); doi:10.1038/ni1006
| Abstract | Full Text (HTML/PDF) |
article
Mechanism of CD1d-restricted natural killer T cell activation during microbial infection
Manfred Brigl, Lynn Bry, Sally C Kent, Jenny E Gumperz and Michael B Brenner
Nature Immunology 4, 1230–1237
(December 2003); doi:10.1038/ni1002
| Abstract | Full Text (HTML/PDF) |
news and views
The NKT cell system: bridging innate and acquired immunity
Masaru Taniguchi, Ken-ichiro Seino and Toshinori Nakayama
Nature Immunology 4, 1164–1165
(December 2003); doi:10.1038/ni1203-1164
| Full Text (HTML/PDF) |
review article
T-cell-antigen recognition and the immunological synapse
Johannes B. Huppa and Mark M. Davis
Nature Reviews Immunology 3, 973–983
(December 2003); doi:10.1038/nri1245
| Abstract | Full Text (HTML / PDF) |
review article
Dendritic-cell control of pathogen-driven T-cell polarization
Martien L. Kapsenberg
Nature Reviews Immunology 3, 984–993
(December 2003); doi:10.1038/nri1246
| Abstract | Full Text (HTML / PDF) |
article
Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure
Mary Tang, Guang Wang, Ping Lu, Richard H Karas, Mark Aronovitz, Scott P Heximer, Kevin M Kaltenbronn, Kendall J Blumer, David P Siderovski, Yan Zhu and Michael E Mendelsohn
Nature Medicine 9, 1506–1512
(December 2003); doi:10.1038/nm958
| Abstract | Full Text (HTML/PDF) |
article
Inositol- and folate-resistant neural tube defects in mice lacking the epithelial-specific factor Grhl-3
Stephen B Ting, Tomasz Wilanowski, Alana Auden, Mark Hall, Anne K Voss, Tim Thomas, Vishwas Parekh, John M Cunningham and Stephen M Jane
Nature Medicine 9, 1513–1519
(December 2003); doi:10.1038/nm961
| Abstract | Full Text (HTML/PDF) |
technical report
Local gene knockdown in the brain using viral-mediated RNA interference
Jonathan D Hommel, Robert M Sears, Dan Georgescu, Diana L Simmons and Ralph J DiLeone
Nature Medicine 9, 1539–1544
(December 2003); doi:10.1038/nm964
| Abstract | Full Text (HTML/PDF) |
news and views
Push me, pull you
Charlotte Schubert
Nature Medicine 9, 1466
(December 2003); doi:10.1038/nm1203-1466
| Full Text (HTML/PDF) |
review article
Applying the principles of stem-cell biology to cancer
Ricardo Pardal, Michael F. Clarke and Sean J. Morrison
Nature Reviews Cancer 3, 895–902
(December 2003); doi:10.1038/nrc1232
| Abstract | Full Text (HTML / PDF) |
review article
Intravital imaging of cell movement in tumours
John Condeelis and Jeffrey E. Segall
Nature Reviews Cancer 3, 921–930
(December 2003); doi:10.1038/nrc1231
| Abstract | Full Text (HTML / PDF) |
perspectives
Opinion: Comparative biology of mouse versus human cells: modelling human cancer in mice
Annapoorni Rangarajan and Robert A. Weinberg
Nature Reviews Cancer 3, 952–959
(December 2003); doi:10.1038/nrc1235
| Abstract | Full Text (HTML / PDF) |
letter
Pyruvate kinase deficiency in mice protects against malaria
Gundula Min-Oo, Anny Fortin, Mi-Fong Tam, André Nantel, Mary M Stevenson and Philippe Gros
Nature Genetics 35, 357–362
(December 2003); doi:10.1038/ng1260
| First Paragraph | Full Text (HTML/PDF) |
review article
Developmental genetics of the female reproductive tract in mammals
Akio Kobayashi and Richard R. Behringer
Nature Reviews Genetics 4, 969–980
(December 2003); doi:10.1038/nrg1225
| Abstract | Full Text (HTML / PDF) |
article
Mobility and cycling of synaptic protein-containing vesicles in axonal growth cone filopodia
Shasta L Sabo and A Kimberley McAllister
Nature Neuroscience 6, 1264–1269
(December 2003); doi:10.1038/nn1149
| Abstract | Full Text (HTML/PDF) |
news and views
A filopodial synapse?
Nature Cell Biology 5, 1047
(December 2003); doi:10.1038/ncb1203-1047
| Full Text (HTML/PDF) |
news and views
Specifying motor neurons: up and down and back to front
William A Harris
Nature Neuroscience 6, 1247–1249
(December 2003); doi:10.1038/nn1203-1247
| Full Text (HTML/PDF) |
review article
Merging functional studies with structures of inward-rectifier K+ channels
Delphine Bichet, Friederike A. Haass and Lily Yeh Jan
Nature Reviews Neuroscience 4, 957–967
(December 2003); doi:10.1038/nrn1244
| Abstract | Full Text (HTML / PDF) |
review article
The molecular basis of water transport in the brain
Mahmood Amiry-Moghaddam and Ole P. Ottersen
Nature Reviews Neuroscience 4, 991–1001
(December 2003); doi:10.1038/nrn1252
| Abstract | Full Text (HTML / PDF) |
letter
Genetically targeted chromophore-assisted light inactivation
Oded Tour, Rene M Meijer, David A Zacharias, Stephen R Adams & Roger Y Tsien
Nature Biotechnology 21, 1505–1508
(December 2003); doi:10.1038/nbt914
| Abstract
| Full Text (HTML/PDF) |
review article
Neuropeptide gene polymorphisms and human behavioural disorders
Akio Inui
Nature Reviews Drug Discovery 2, 986–998
(December 2003); doi:10.1038/nrd1252
| Abstract | Full Text (HTML / PDF) |
article
Cellular stabilization of the melatonin rhythm enzyme induced by nonhydrolyzable phosphonate incorporation
Weiping Zheng, Zhongsen Zhang, Surajit Ganguly, Joan L Weller, David C Klein and Philip A Cole
Nature Structural Biology 10, 1054–1057
(December 2003); doi:10.1038/nsb1005
| Abstract | Full Text (HTML/PDF) |
article
Centre-surround inhibition among olfactory bulb glomeruli
J. L. Aungst, P. M. Heyward , A. C. Puche, S. V. Karnup, A. Hayar, G. Szabo and M. T. Shipley
Nature 426, 623–629
(11 December 2003); doi:10.1038/nature02185
| Abstract | Full Text (HTML / PDF) |
letters to nature
Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1
Joseph T. Opferman, Anthony Letai, Caroline Beard, Mia D. Sorcinelli, Christy C. Ong and Stanley J. Korsmeyer
Nature 426, 671–676
(11 December 2003); doi:10.1038/nature02067
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Optimization of specificity in a cellular protein interaction network by negative selection
Ali Zarrinpar, Sang-Hyun Park and Wendell A. Lim
Nature 426, 676–680
(11 December 2003); doi:10.1038/nature02178
| First Paragraph | Full Text (HTML / PDF) |
news and views
Signal transduction: Molecular monogamy
Drew Endy and Michael B. Yaffe
Nature 426, 614–615
(11 December 2003); doi:10.1038/426614a
| Full Text (HTML / PDF) |
brief communication
Genetics: Influence of TOR kinase on lifespan in C. elegans
Tibor Vellai, Krisztina Takacs-Vellai, Yue Zhang, Attila L. Kovacs, László Orosz and Fritz Müller
Nature 426, 620
(11 December 2003); doi:10.1038/426620a
| First Paragraph | Full Text (HTML / PDF) |
letter
Scaffold-mediated symmetry breaking by Cdc42p
Javier E. Irazoqui, Amy S. Gladfelter and Daniel J. Lew
Nature Cell Biology 5, 1062–1070
(December 2003); doi:10.1038/ncb1068
| First Paragraph | Full Text (HTML/PDF) |
news and views
Go ahead, break my symmetry!
Kendall J. Blumer and John A. Cooper
Nature Cell Biology 5, 1048–1049
(December 2003); doi:10.1038/ncb1203-1048
| Full Text (HTML/PDF) |
letter
Securin and B-cyclin/CDK are the only essential targets of the APC
Brian R. Thornton and David P. Toczyski
Nature Cell Biology 5, 1090–1094
(December 2003); doi:10.1038/ncb1066
| First Paragraph | Full Text (HTML/PDF) |
perspectives
The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?
Dieter A. Wolf, Chunshui Zhou and Susan Wee
Nature Cell Biology 5, 1029–1033
(December 2003); doi:10.1038/ncb1203-1029
| Abstract | Full Text (HTML/PDF) |
review article
Met, metastasis, motility and more
Carmen Birchmeier , Walter Birchmeier , Ermanno Gherardi and George F. Vande Woude
Nature Reviews Molecular Cell Biology 4, 915–925
(December 2003); doi:10.1038/nrm1261
| Abstract | Full Text (HTML / PDF) |
perspectives
Opinion: Lateral phosphorylation propagation: an aspect of feedback signalling?
Christian Tischer and Philippe I. H. Bastiaens
Nature Reviews Molecular Cell Biology 4, 971–975
(December 2003); doi:10.1038/nrm1258
| Abstract | Full Text (HTML / PDF) |
article
Mast cell-derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection
James B McLachlan, Justin P Hart, Salvatore V Pizzo, Christopher P Shelburne, Herman F Staats, Michael D Gunn and Soman N Abraham
Nature Immunology 4, 1199–1205
(December 2003); doi:10.1038/ni1005
| Abstract | Full Text (HTML/PDF) |
news and views
Mast cells to the defense
Stephen J Galli and Susumu Nakae
Nature Immunology 4, 1160–1162
(December 2003); doi:10.1038/ni1203-1160
| Full Text (HTML/PDF) |
article
Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways
Kasper Hoebe, Edith M Janssen, Sung O Kim, Lena Alexopoulou, Richard A Flavell, Jiahuai Han and Bruce Beutler
Nature Immunology 4, 1223–1229
(December 2003); doi:10.1038/ni1010
| Abstract | Full Text (HTML/PDF) |
news and views
Adjuvants and their signaling pathways: beyond TLRs
Egil Lien and Douglas T Golenbock
Nature Immunology 4, 1162–1164
(December 2003); doi:10.1038/ni1203-1162
| Full Text (HTML/PDF) |
review article
Suppressors of cytokine signaling and immunity
Masato Kubo, Toshikatsu Hanada and Akihiko Yoshimura
Nature Immunology 4, 1169–1176
(December 2003); doi:10.1038/ni1012
| Abstract | Full Text (HTML/PDF) |
review article
CD28-mediated co-stimulation: a quantitative support for TCR signalling
Oreste Acuto and Frédérique Michel
Nature Reviews Immunology 3, 939–951
(December 2003); doi:10.1038/nri1248
| Abstract | Full Text (HTML / PDF) |
perspectives
Opinion: Taking our breath away: dendritic cells in the pathogenesis of asthma
Bart N. Lambrecht and Hamida Hammad
Nature Reviews Immunology 3, 994–1003
(December 2003); doi:10.1038/nri1249
| Abstract | Full Text (HTML / PDF) |
article
Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice
Taku Okazaki, Yoshimasa Tanaka, Ryosuke Nishio, Tamotsu Mitsuiye, Akira Mizoguchi, Jian Wang, Masayoshi Ishida, Hiroshi Hiai, Akira Matsumori, Nagahiro Minato and Tasuku Honjo
Nature Medicine 9, 1477–1483
(December 2003); doi:10.1038/nm955
| Abstract | Full Text (HTML/PDF) |
article
Dendritic cell-induced autoimmune heart failure requires cooperation between adaptive and innate immunity
Urs Eriksson, Romeo Ricci, Lukas Hunziker, Michael O Kurrer, Gavin Y Oudit, Tania H Watts, Ivo Sonderegger, Kurt Bachmaier, Manfred Kopf and Josef M Penninger
Nature Medicine 9, 1484–1490
(December 2003); doi:10.1038/nm960
| Abstract | Full Text (HTML/PDF) |
news and views
Dilated cardiomyopathy: learning to live with yourself
W Robb MacLellan and Aldons J Lusis
Nature Medicine 9, 1455–1456
(December 2003); doi:10.1038/nm1203-1455
| Full Text (HTML/PDF) |
review article
Hedgehog signalling in cancer formation and maintenance
Marina Pasca di Magliano and Matthias Hebrok
Nature Reviews Cancer 3, 903–911
(December 2003); doi:10.1038/nrc1229
| Abstract | Full Text (HTML / PDF) |
review article
The 14-3-3 cancer connection
Heiko Hermeking
Nature Reviews Cancer 3, 931–943
(December 2003); doi:10.1038/nrc1230
| Abstract | Full Text (HTML / PDF) |
letter
WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion
Kristopher T Kahle, Frederick H Wilson, Qiang Leng, Maria D Lalioti, Anthony D O'Connell, Ke Dong, Alicia K Rapson, Gordon G MacGregor, Gerhard Giebisch, Steven C Hebert and Richard P Lifton
Nature Genetics 35, 372–376
(December 2003); doi:10.1038/ng1271
| First Paragraph | Full Text (HTML/PDF) |
news and views
A molecular switch controlling renal sodium and potassium excretion
René J M Bindels
Nature Genetics 35, 302–303
(December 2003); doi:10.1038/ng1203-302
| Full Text (HTML/PDF) |
article
The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons
John C Lin, Wei-Hsien Ho, Austin Gurney and Arnon Rosenthal
Nature Neuroscience 6, 1270–1276
(December 2003); doi:10.1038/nn1148
| Abstract | Full Text (HTML/PDF) |
article
Non-proliferative effects of lysophosphatidic acid enhance cortical growth and folding
Marcy A Kingsbury, Stevens K Rehen, James J A Contos, Christine M Higgins and Jerold Chun
Nature Neuroscience 6, 1292–1299
(December 2003); doi:10.1038/nn1157
| Abstract | Full Text (HTML/PDF) |
review article
Signalling mechanisms mediating neuronal responses to guidance cues
Kun-Liang Guan and Yi Rao
Nature Reviews Neuroscience 4, 941–956
(December 2003); doi:10.1038/nrn1254
| Abstract | Full Text (HTML / PDF) |
review article
Proteinase-activated receptors in the nervous system
Farshid Noorbakhsh , Nathalie Vergnolle , Morley D. Hollenberg and Christopher Power
Nature Reviews Neuroscience 4, 981–990
(December 2003); doi:10.1038/nrn1255
| Abstract | Full Text (HTML / PDF) |
article
Fluorobodies combine GFP fluorescence with the binding characteristics of antibodies
Ahmet Zeytun, Andreas Jeromin, Bethe A Scalettar, Geoffrey S Waldo & Andrew RM Bradbury
Nature Biotechnology 21,1473–1479
(December 2003); doi:10.1038/nbt911
| Abstract | Full Text (HTML/PDF) |
news and views
Fluorescent proteins with ties that bind
Timothy A Ryan
Nature Biotechnology 21,1447–1448
(December 2003); doi:10.1038/nbt1203-1447
| Full Text (HTML/PDF) |
review article
GLIA: A novel drug discovery target for clinical pain
Linda R. Watkins and Steven F. Maier
Nature Reviews Drug Discovery 2, 973–985
(December 2003); doi:10.1038/nrd1251
| Abstract | Full Text (HTML / PDF) |
review article
Opportunities in somatostatin research: biological, chemical and therapeutic aspects
Gisbert Weckbecker, Ian Lewis, Rainer Albert, Herbert A. Schmid, Daniel Hoyer and Christian Bruns
Nature Reviews Drug Discovery 2, 999–1017
(December 2003); doi:10.1038/nrd1255
| Abstract | Full Text (HTML / PDF) |
article
Tom40 protein import channel binds to non-native proteins and prevents their aggregation
Masatoshi Esaki, Takashi Kanamori, Shuh-ichi Nishikawa, Injae Shin, Peter G Schultz and Toshiya Endo
Nature Structural Biology 10, 988–994
(December 2003); doi:10.1038/nsb1008
| Abstract | Full Text (HTML/PDF) |
news and views
Tom40: more than just a channel
Wolfgang Voos
Nature Structural Biology 10, 981–982
(December 2003); doi:10.1038/nsb1203-981
| Full Text (HTML/PDF) |
article
Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor
Louis Renault, Bernard Guibert and Jacqueline Cherfils
Nature 426, 525–530
(04 December 2003); doi:10.1038/nature02197
| Abstract | Full Text (HTML / PDF) |
letters to nature
Delta-promoted filopodia mediate long-range lateral inhibition in Drosophila
Cyrille de Joussineau, Jonathan Soulé, Marianne Martin, Christelle Anguille, Philippe Montcourrier and Daniel Alexandre
Nature 426, 555–559
(04 December 2003); doi:10.1038/nature02157
| First Paragraph | Full Text (HTML / PDF) |
news and views
Developmental biology: Long-range signalling by touch
Stephen M. Cohen
Nature 426, 503–504
(04 December 2003); doi:10.1038/426503a
| Full Text (HTML / PDF) |
letters to nature
Synaptotagmin I is necessary for compensatory synaptic vesicle endocytosis in vivo
Kira E. Poskanzer, Kurt W. Marek, Sean T. Sweeney and Graeme W. Davis
Nature 426, 559–563
(04 December 2003); doi:10.1038/nature02184
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Lipid packing sensed by ArfGAP1 couples COPI coat disassembly to membrane bilayer curvature
Joëlle Bigay, Pierre Gounon, Sylviane Robineau and Bruno Antonny
Nature 426, 563–566
(04 December 2003); doi:10.1038/nature02108
| First Paragraph | Full Text (HTML / PDF) |
news and views
Membrane trafficking: Coat control by curvature
Jennifer Lippincott-Schwartz and Wei Liu
Nature 426, 507–508
(04 December 2003); doi:10.1038/426507a
| Full Text (HTML / PDF) |
letters to nature
Targeted degradation of TOC1 by ZTL modulates circadian function in Arabidopsis thaliana
Paloma Más, Woe-Yeon Kim, David E. Somers and Steve A. Kay
Nature 426, 567–570
(04 December 2003); doi:10.1038/nature02163
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2
Kristina Lorenz, Martin J. Lohse and Ursula Quitterer
Nature 426, 574–579
(04 December 2003); doi:10.1038/nature02158
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Release of eIF6 (p27BBP) from the 60S subunit allows 80S ribosome assembly
Marcello Ceci, Cristina Gaviraghi, Chiara Gorrini, Leonardo A. Sala, Nina Offenhäuser, Pier Carlo Marchisio and Stefano Biffo
Nature 426, 579–584
(04 December 2003); doi:10.1038/nature02160
| First Paragraph | Full Text (HTML / PDF) |
news and views
Medicine: Taking apart a cancer protein
Pier Paolo Scaglioni and Pier Paolo Pandolfi
Nature 426, 512–513
(04 December 2003); doi:10.1038/426512a
| Full Text (HTML / PDF) |
review article
TRP channels as cellular sensors
David E. Clapham
Nature 426, 517–524
(04 December 2003); doi:10.1038/nature02196
| Abstract | Full Text (HTML / PDF) |
article
Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis
Darren Boehning, Randen L. Patterson, Leela Sedaghat, Natalia O. Glebova, Tomohiro Kurosaki and Solomon H. Snyder
Nature Cell Biology 5, 1051–1061
(December 2003); doi:10.1038/ncb1063
| Abstract | Full Text (HTML/PDF) |
news and views
Calcium orchestrates apoptosis
Mark P. Mattson and Sic L. Chan
Nature Cell Biology 5, 1041–1043
(December 2003); doi:10.1038/ncb1203-1041
| Full Text (HTML/PDF) |
letter
Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock
Mark T. Uhlik, Amy N. Abell, Nancy L. Johnson, Weiyong Sun, Bruce D. Cuevas, Katherine E. Lobel-Rice, Eric A. Horne, Mark L. Dell'Acqua and Gary L. Johnson
Nature Cell Biology 5, 1104–1110
(December 2003); doi:10.1038/ncb1071
| First Paragraph | Full Text (HTML/PDF) |
letter
A new sperm-specific Na+/H+ Exchanger required for sperm motility and fertility
Dan Wang, Shelby M. King, Timothy A. Quill, Lynda K. Doolittle and David L. Garbers
Nature Cell Biology 5, 1117–1122
(December 2003); doi:10.1038/ncb1072
| First Paragraph | Full Text (HTML/PDF) |
review article
Syndecans: proteoglycan regulators of cell-surface microdomains?
John R. Couchman
Nature Reviews Molecular Cell Biology 4, 926–938
(December 2003); doi:10.1038/nrm1257
| Abstract | Full Text (HTML / PDF) |
article
Deletion of β-catenin impairs T cell development
Youyuan Xu, Daliya Banerjee, Joerg Huelsken, Walter Birchmeier and Jyoti Misra Sen
Nature Immunology 4, 1177–1182
(December 2003); doi:10.1038/ni1008
| Abstract | Full Text (HTML/PDF) |
article
Active recruitment of DNA methyltransferases regulates interleukin 4 in thymocytes and T cells
Karen W Makar, Mercedes Pérez-Melgosa, Maria Shnyreva, William M Weaver, David R Fitzpatrick and Christopher B Wilson
Nature Immunology 4, 1183–1190
(December 2003); doi:10.1038/ni1004
| Abstract | Full Text (HTML/PDF) |
article
Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility
Kelly D Smith, Erica Andersen-Nissen, Fumitaka Hayashi, Katie Strobe, Molly A Bergman, Sara L Rassoulian Barrett, Brad T Cookson and Alan Aderem
Nature Immunology 4, 1247–1253
(December 2003); doi:10.1038/ni1011
| Abstract | Full Text (HTML/PDF) |
news and views
TLR5 takes aim at bacterial propeller
Jean-Marc Reichhart
Nature Immunology 4, 1159–1160
(December 2003); doi:10.1038/ni1203-1159
| Full Text (HTML/PDF) |
review article
Human CD8+ T-cell differentiation in response to viruses
René A. W. van Lier, Ineke J. M. ten Berge and Laila E. Gamadia
Nature Reviews Immunology 3, 931–939
(December 2003); doi:10.1038/nri1254
| Abstract | Full Text (HTML / PDF) |
article
Hsp70 promotes antigen-presenting cell function and converts T-cell tolerance to autoimmunity in vivo
Douglas G Millar, Kristine M Garza, Bernhard Odermatt, Alisha R Elford, Nobuyuki Ono, Zihai Li and Pamela S Ohashi
Nature Medicine 9, 1469–1476
(December 2003); doi:10.1038/nm962
| Abstract | Full Text (HTML/PDF) |
news and views
Autoimmunity heats up
Andrew E Gelman and Laurence A Turka
Nature Medicine 9, 1465–1466
(December 2003); doi:10.1038/nm1203-1465
| Full Text (HTML/PDF) |
article
Muscle-specific Pparg deletion causes insulin resistance
Andrea L Hevener, Weimin He, Yaacov Barak, Jamie Le, Gautam Bandyopadhyay, Peter Olson, Jason Wilkes, Ronald M Evans and Jerrold Olefsky
Nature Medicine 9, 1491–1497
(December 2003); doi:10.1038/nm956
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JAKing up immunosuppression
Megan Sykes
Nature Medicine 9, 1458–1459
(December 2003); doi:10.1038/nm1203-1458
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review article
Cancer pharmacogenetics: polymorphisms, pathways and beyond
Cornelia M. Ulrich, Kim Robien and Howard L. McLeod
Nature Reviews Cancer 3, 912–920
(December 2003); doi:10.1038/nrc1233
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perspectives
Opinion: Searching for the elusive targets of farnesyltransferase inhibitors
Saïd M. Sebti and Channing J. Der
Nature Reviews Cancer 3, 945–951
(December 2003); doi:10.1038/nrc1234
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letter
Mitochondrial dysfunction and apoptosis in myopathic mice with collagen VI deficiency
William A Irwin, Natascha Bergamin, Patrizia Sabatelli, Carlo Reggiani, Aram Megighian, Luciano Merlini, Paola Braghetta, Marta Columbaro, Dino Volpin, Giorgio M Bressan, Paolo Bernardi and Paolo Bonaldo
Nature Genetics 35, 367–371
(December 2003); doi:10.1038/ng1270
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The collagen-mitochondria connection
Rosario Rizzuto
Nature Genetics 35, 300–301
(December 2003); doi:10.1038/ng1203-300
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review article
The diverse roles of ubiquitin and the 26S proteasome in the life of plants
James A. Sullivan, Ken Shirasu and Xing Wang Deng
Nature Reviews Genetics 4, 948–958
(December 2003); doi:10.1038/nrg1228
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article
Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development
Akihiro Nishida, Akiko Furukawa, Chieko Koike, Yasuo Tano, Shinichi Aizawa, Isao Matsuo and Takahisa Furukawa
Nature Neuroscience 6, 1255–1263
(December 2003); doi:10.1038/nn1155
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article
Layering defect in p35 deficiency is linked to improper neuronal-glial interaction in radial migration
Amitabh Gupta, Kamon Sanada, David T Miyamoto, Susan Rovelstad, Bagirathy Nadarajah, Alan L Pearlman, Jan Brunstrom and Li-Huei Tsai
Nature Neuroscience 6, 1284–1291
(December 2003); doi:10.1038/nn1151
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Folding the cortex
Annette Markus
Nature Neuroscience 6, 1249
(December 2003); doi:10.1038/nn1203-1249
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review article
The local differentiation of myelinated axons at nodes of Ranvier
Sebastian Poliak and Elior Peles
Nature Reviews Neuroscience 4, 968–980
(December 2003); doi:10.1038/nrn1253
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review article
The developmental role of serotonin: news from mouse molecular genetics
Patricia Gaspar, Olivier Cases and Luc Maroteaux
Nature Reviews Neuroscience 4, 1002–1012
(December 2003); doi:10.1038/nrn1256
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letters
Analyzing antibody specificity with whole proteome microarrays
Gregory A Michaud, Michael Salcius, Fang Zhou, Rhonda Bangham, Jaclyn Bonin, Hong Guo, Michael Snyder, Paul F Predki & Barry I Schweitzer
Nature Biotechnology 4, 1509–1512
(December 2003); doi:10.1038/nbt910
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Cloning by numbers
Louis-Marie Houdebine
Nature Biotechnology 21, 1451–1452
(December 2003); doi:10.1038/nbt1203-1451
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review article
Tissue microarrays in drug discovery
Guido Sauter, Ronald Simon and Kenneth Hillan
Nature Reviews Drug Discovery 2, 962–972
(December 2003); doi:10.1038/nrd1254
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article
Bistable regulation of integrin adhesiveness by a bipolar metal ion cluster
JianFeng Chen, Azucena Salas and Timothy A Springer
Nature Structural Biology 10, 995–1001
(December 2003); doi:10.1038/nsb1011
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Histone H1.2 as a trigger for apoptosis
Nieng Yan and Yigong Shi
Nature Structural Biology 10, 983–985
(December 2003); doi:10.1038/nsb1203-983
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