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The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.
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article
Summing up the noise in gene networks
Johan Paulsson
Nature 427, 415–418
(29 January 2004); doi:10.1038/nature02257
| Abstract | Full Text (HTML / PDF) |
article
fgf8 mRNA decay establishes a gradient that couples axial elongation to patterning in the vertebrate embryo
Julien Dubrulle and Olivier Pourquié
Nature 427, 419–422
(29 January 2004); doi:10.1038/nature02216
| Abstract | Full Text (HTML / PDF) |
news and views
Developmental biology: Tail of decay
Alexander F. Schier
Nature 427, 403–404
(29 January 2004); doi:10.1038/427403a
| Full Text (HTML / PDF) |
letters to nature
SOL-1 is a CUB-domain protein required for GLR-1 glutamate receptor function in C. elegans
Yi Zheng, Jerry E. Mellem, Penelope J. Brockie, David M. Madsen and Andres V. Maricq
Nature 427, 451–457
(29 January 2004); doi:10.1038/nature02244
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
The RickA protein of Rickettsia conorii activates the Arp2/3 complex
Edith Gouin, Coumaran Egile, Pierre Dehoux, Véronique Villiers, Josephine Adams, Frank Gertler, Rong Li and Pascale Cossart
Nature 427, 457–461
(29 January 2004); doi:10.1038/nature02318
| First Paragraph | Full Text (HTML / PDF) |
news and views
Cell biology: Pathogen propulsion
Deepa Nath
Nature 427, 407
(29 January 2004); doi:10.1038/427407a
| Full Text (HTML / PDF) |
letters to nature
The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore
Jason E. Kokoszka , Katrina G. Waymire, Shawn E. Levy, James E. Sligh, Jiyang Cai, Dean P. Jones, Grant R. MacGregor and Douglas C. Wallace
Nature 427, 461–465
(29 January 2004); doi:10.1038/nature02229
| First Paragraph | Full Text (HTML / PDF) |
letter
Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization
Ajamete Kaykas, Julia Yang-Snyder, Madeleine Héroux, Kavita V. Shah, Michel Bouvier and Randall T. Moon
Nature Cell Biology 6, 52–58
(January 2004); doi:10.1038/ncb1081
| First Paragraph | Full Text (HTML/PDF) |
letter
Late-G1 cyclin-CDK activity is essential for control of cell morphogenesis in budding yeast
Jason Moffat and Brenda Andrews
Nature Cell Biology 6, 59–66
(January 2004); doi:10.1038/ncb1078
| First Paragraph | Full Text (HTML/PDF) |
perspectives
Controlling Abl: auto-inhibition and co-inhibition?
Jean Y. J. Wang
Nature Cell Biology 6, 3–7
(January 2004); doi:10.1038/ncb0104-3
| Abstract | Full Text (HTML/PDF) |
review article
The GGA proteins: adaptors on the move
Juan S. Bonifacino
Nature Reviews Molecular Cell Biology 5, 23–32
(January 2004); doi:10.1038/nrm1279
| Abstract | Full Text (HTML / PDF) |
article
An essential function for the nuclear receptor RORγt in the generation of fetal lymphoid tissue inducer cells
Gérard Eberl, Shana Marmon, Mary-Jean Sunshine, Paul D Rennert, Yongwon Choi and Dan R Littman
Nature Immunology 5, 64–73
(January 2004); doi:10.1038/ni1022
| Abstract | Full Text (HTML/PDF) |
news and views
Lymphoid organogenesis: getting the green light from RORγt
Martin Lipp and Gerd Müller
Nature Immunology 5, 12–14
(January 2004); doi:10.1038/ni0104-12
| Full Text (HTML/PDF) |
article
Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3
Qiaojia Huang, Jianhua Yang, Yong Lin, Christopher Walker, Jinke Cheng, Zheng-gang Liu and Bing Su
Nature Immunology 5, 98–103
(January 2004); doi:10.1038/ni1014
| Abstract | Full Text (HTML/PDF) |
news and views
How resting T cells deMURR HIV infection
Warner C Greene
Nature Immunology 5, 18–19
(January 2004); doi:10.1038/ni0104-18
| Full Text (HTML/PDF) |
review article
Dendritic cells: emerging pharmacological targets of immunosuppressive drugs
Holger Hackstein and Angus W. Thomson
Nature Reviews Immunology 4, 24–35
(January 2004); doi:10.1038/nri1256
| Abstract | Full Text (HTML / PDF) |
article
Molecular determinants of resistance to antiandrogen therapy
Charlie D Chen, Derek S Welsbie, Chris Tran, Sung Hee Baek, Randy Chen, Robert Vessella, Michael G Rosenfeld and Charles L Sawyers
Nature Medicine 10, 33–39
(January 2004); doi:10.1038/nm972
| Abstract | Full Text (HTML/PDF) |
news and views
Androgen receptor outwits prostate cancer drugs
John T Isaacs and William B Isaacs
Nature Medicine 10, 26–27
(January 2004); doi:10.1038/nm0104-26
| Full Text (HTML/PDF) |
brief communication
Modifying quinolone antibiotics yields new anxiolytics
Timothy B C Johnstone, Derk J Hogenkamp, Leanne Coyne, Jiping Su, Robert F Halliwell, Minhtam B Tran, Ryan F Yoshimura, Wen-Yen Li, Jeff Wang and Kelvin W Gee
Nature Medicine 10, 31–32
(January 2004); doi:10.1038/nm967
| First Paragraph | Full Text (HTML/PDF) |
technical report
A transgenic mouse model for monitoring endoplasmic reticulum stress
Takao Iwawaki, Ryoko Akai, Kenji Kohno and Masayuki Miura
Nature Medicine 10, 98–102
(January 2004); doi:10.1038/nm970
| Abstract | Full Text (HTML/PDF) |
news and views
HTLV-1 sweet-talks its way into cells
Julie Overbaugh
Nature Medicine 10, 20–21
(January 2004); doi:10.1038/nm0104-20
| Full Text (HTML/PDF) |
review article
Mucins in cancer: protection and control of the cell surface
Michael A. Hollingsworth and Benjamin J. Swanson
Nature Reviews Cancer 4, 45–60
(January 2004); doi:10.1038/nrc1251
| Abstract | Full Text (HTML / PDF) |
perspectives
Opinion: Impact of race/ethnicity on molecular pathways in human cancer
John K. Wiencke
Nature Reviews Cancer 4, 79–84
(January 2004); doi:10.1038/nrc1257
| Abstract | Full Text (HTML / PDF) |
letter
Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex
Volney L Sheen, Vijay S Ganesh, Meral Topcu, Guillaume Sebire, Adria Bodell, R Sean Hill, P Ellen Grant, Yin Yao Shugart, Jaime Imitola, Samia J Khoury, Renzo Guerrini and Christopher A Walsh
Nature Genetics 36, 69–76
(January 2004); doi:10.1038/ng1276
| First Paragraph | Full Text (HTML/PDF) |
letter
Conversion of biliary system to pancreatic tissue in Hes1-deficient mice
Ryo Sumazaki, Nobuyoshi Shiojiri, Shigemi Isoyama, Masayuki Masu, Kazuko Keino-Masu, Mitsujiro Osawa, Hiromitsu Nakauchi, Ryoichiro Kageyama and Akira Matsui
Nature Genetics 36, 83–87
(January 2004); doi:10.1038/ng1273
| First Paragraph | Full Text (HTML/PDF) |
article
Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways
Ainslie B Parsons, Renée L Brost, Huiming Ding, Zhijian Li, Chaoying Zhang, Bilal Sheikh, Grant W Brown, Patricia M Kane, Timothy R Hughes & Charles Boone
Nature Biotechnology 22, 62–69
(January 2004); doi:10.1038/nbt919
| Abstract | Full Text (HTML/PDF) |
news and views
The biological magic behind the bullets
Brent R Stockwell
Nature Biotechnology 22, 37–38
(January 2004); doi:10.1038/nbt0104-37
| Full Text (HTML/PDF) |
article
Principles of transcriptional control in the metabolic network of Saccharomyces cerevisiae
Jan Ihmels, Ronen Levy & Naama Barkai
Nature Biotechnology 22, 86–92
(January 2004); doi:10.1038/nbt918
| Abstract | Full Text (HTML/PDF) |
article
A conformational switch in the Piccolo C2A domain regulated by alternative splicing
Jesus Garcia, Stefan H Gerber, Shuzo Sugita, Thomas C Südhof and Josep Rizo
Nature Structural and Molecular Biology 11, 45–53
(January 2004); doi:10.1038/nsmb707
| Abstract | Full Text (HTML/PDF) |
news and views
Sculpting a domain by splicing
Bazbek Davletov and José L Jiménez
Nature Structural and Molecular Biology 11, 4–5
(January 2004); doi:10.1038/nsmb0104-4
| Full Text (HTML/PDF) |
article
The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor
Benjamin E Turk, Thiang Yian Wong, Robert Schwarzenbacher, Emily T Jarrell, Stephen H Leppla, R John Collier, Robert C Liddington and Lewis C Cantley
Nature Structural and Molecular Biology 11, 60–66
(January 2004); doi:10.1038/nsmb708
| Abstract | Full Text (HTML/PDF) |
article
Identification of small molecule inhibitors of anthrax lethal factor
Rekha G Panchal, Ann R Hermone, Tam Luong Nguyen, Thiang Yian Wong, Robert Schwarzenbacher, James Schmidt, Douglas Lane, Connor McGrath, Benjamin E Turk, James Burnett, M Javad Aman, Stephen Little, Edward A Sausville, Daniel W Zaharevitz, Lewis C Cantley, Robert C Liddington, Rick Gussio and Sina Bavari
Nature Structural and Molecular Biology 11, 67–72
(January 2004); doi:10.1038/nsmb711
| Abstract | Full Text (HTML/PDF) |
article
Structural basis for recruitment of GRIP domain golgin-245 by small GTPase Arl1
Mousheng Wu, Lei Lu, Wanjin Hong and Haiwei Song
Nature Structural and Molecular Biology 11, 86–94
(January 2004); doi:10.1038/nsmb714
| Abstract | Full Text (HTML/PDF) |
review article
Fluorescent probes for proteolysis: Tools for drug discovery
Jacques Neefjes and Nico P. Dantuma
Nature Reviews Drug Discovery 3, 58–69
(January 2004); doi:10.1038/nrd1282
| Abstract | Full Text (HTML / PDF) |
article
Structure of the dengue virus envelope protein after membrane fusion
Yorgo Modis, Steven Ogata, David Clements and Stephen C. Harrison
Nature 427, 313–319
(22 January 2004); doi:10.1038/nature02165
| Summary | Full Text (HTML / PDF) |
article
Conformational change and protein-protein interactions of the fusion protein of Semliki Forest virus
Don L. Gibbons, Marie-Christine Vaney, Alain Roussel, Armelle Vigouroux, Brigid Reilly, Jean Lepault, Margaret Kielian and Félix A. Rey
Nature 427, 320–325
(22 January 2004); doi:10.1038/nature02239
| Summary | Full Text (HTML / PDF) |
news and views
Virology: A class act
Theodore S. Jardetzky and Robert A. Lamb
Nature 427, 307–308
(22 January 2004); doi:10.1038/427307a
| Full Text (HTML / PDF) |
letters to nature
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
Mehrdad Matloubian, Charles G. Lo, Guy Cinamon, Matthew J. Lesneski, Ying Xu, Volker Brinkmann, Maria L. Allende, Richard L. Proia and Jason G. Cyster
Nature 427, 355–360
(22 January 2004); doi:10.1038/nature02284
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
The mitochondrial calcium uniporter is a highly selective ion channel
Yuriy Kirichok, Grigory Krapivinsky and David E. Clapham
Nature 427, 360–364
(22 January 2004); doi:10.1038/nature02246
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
The MAPK Hog1 recruits Rpd3 histone deacetylase to activate osmoresponsive genes
Eulália de Nadal, Meritxell Zapater, Paula M. Alepuz, Lauro Sumoy, Glòria Mas and Francesc Posas
Nature 427, 370–374
(22 January 2004); doi:10.1038/nature02258
| First Paragraph | Full Text (HTML / PDF) |
letter
An NDPase links ADAM protease glycosylation with organ morphogenesis in C. elegans
Kiyoji Nishiwaki, Yukihiko Kubota, Yuko Chigira, Samir Kumar Roy, Maho Suzuki, Mara Schvarzstein, Yoshifumi Jigami, Naoki Hisamoto and Kunihiro Matsumoto
Nature Cell Biology 6, 31–37
(January 2004); doi:10.1038/ncb1079
| First Paragraph | Full Text (HTML/PDF) |
news and views
Sweet control of cell migration, cytokinesis and organogenesis
Benjamin Podbilewicz
Nature Cell Biology 6, 9–11
(January 2004); doi:10.1038/ncb0104-9
| Full Text (HTML/PDF) |
letter
The transmembrane protein XFLRT3 forms a complex with FGF receptors and promotes FGF signalling
Ralph T. Böttcher, Nicolas Pollet, Hajo Delius and Christof Niehrs
Nature Cell Biology 6, 38–44
(January 2004); doi:10.1038/ncb1082
| First Paragraph | Full Text (HTML/PDF) |
review article
Regulation of the c-Abl and Bcr-Abl Tyrosine Kinases
Oliver Hantschel and Giulio Superti-Furga
Nature Reviews Molecular Cell Biology 5, 33–44
(January 2004); doi:10.1038/nrm1280
| Summary | Full Text (HTML / PDF) |
article
Gadd45β is important for perpetuating cognate and inflammatory signals in T cells
Binfeng Lu, Anthony F Ferrandino and Richard A Flavell
Nature Immunology 5, 38–44
(January 2004); doi:10.1038/ni1020
| Abstract | Full Text (HTML/PDF) |
article
Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins
Marika J Karkkainen, Paula Haiko, Kirsi Sainio, Juha Partanen, Jussi Taipale, Tatiana V Petrova, Michael Jeltsch, David G Jackson, Marja Talikka, Heikki Rauvala, Christer Betsholtz and Kari Alitalo
Nature Immunology 5, 74–80
(January 2004); doi:10.1038/ni1013
| Abstract | Full Text (HTML/PDF) |
news and views
Genes tell lymphatics to sprout or not
Judah Folkman and Arja Kaipainen
Nature Immunology 5, 11–12
(January 2004); doi:10.1038/ni0104-11
| Full Text (HTML/PDF) |
review article
Immunity to fungal infections
Luigina Romani
Nature Reviews Immunology 4, 11–24
(January 2004); doi:10.1038/nri1255
| Summary | Full Text (HTML / PDF) |
article
Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor
Noboru Sato, Laurent Meijer, Leandros Skaltsounis, Paul Greengard and Ali H Brivanlou
Nature Medicine 10, 55–63
(January 2004); doi:10.1038/nm979
| Abstract | Full Text (HTML/PDF) |
news and views
Embryonic stem cells: staying plastic on plastic
Kinichi Nakashima, Sophia Colamarino and Fred H Gage
Nature Medicine 10, 23–24
(January 2004); doi:10.1038/nm0104-23
| Full Text (HTML/PDF) |
news and views
THC: moderation during implantation
Daniele Piomelli
Nature Medicine 10, 19–20
(January 2004); doi:10.1038/nm0104-19
| Full Text (HTML/PDF) |
review article
Peroxisome-proliferator-activated receptors and cancers: complex stories
Liliane Michalik, Béatrice Desvergne and Walter Wahli
Nature Reviews Cancer 4, 61–70
(January 2004); doi:10.1038/nrc1254
| Summary | Full Text (HTML / PDF) |
article
Developmental switch from GABA to glycine release in single central synaptic terminals
Junichi Nabekura, Shutaro Katsurabayashi, Yasuhiro Kakazu, Shumei Shibata, Atsushi Matsubara, Shozo Jinno, Yoshito Mizoguchi, Akira Sasaki and Hitoshi Ishibashi
Nature Neuroscience 7, 17–23
(January 2004); doi:10.1038/nn1170
| Abstract | Full Text (HTML/PDF) |
news and views
Developing neurons make the switch
Anthony N van den Pol
Nature Neuroscience 7, 7–8
(January 2004); doi:10.1038/nn0104-7
| Full Text (HTML/PDF) |
review article
Structural plasticity and memory
Raphael Lamprecht and Joseph LeDoux
Nature Reviews Neuroscience 5, 45–54
(January 2004); doi:10.1038/nrn1301
| Summary | Full Text (HTML / PDF) |
letter
Unraveling protein interaction networks with near-optimal efficiency
Michael Lappe & Liisa Holm
Nature Structural Biology 22, 98–103
(January 2004); doi:10.1038/nbt921
| Abstract | Full Text (HTML/PDF) |
perspective
The use of nanocrystals in biological detection
Paul Alivisatos
Nature Biotechnology 22, 47–52
(January 2004); doi:10.1038/nbt927
| Abstract | Full Text (HTML/PDF) |
review article
Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model
Anthony W. Norman , Mathew T. Mizwicki and Derek P. G. Norman
Nature Reviews Drug Discovery 3, 27–41
(January 2004); doi:10.1038/nrd1283
| Summary | Full Text (HTML / PDF) |
article
Substrate twinning activates the signal recognition particle and its receptor
Pascal F. Egea, Shu-ou Shan, Johanna Napetschnig, David F. Savage, Peter Walter and Robert M. Stroud
Nature 427, 215–221
(15 January 2004); doi:10.1038/nature02250
| Abstract | Full Text (HTML / PDF) |
letters to nature
Immune recognition of a human renal cancer antigen through post-translational protein splicing
Ken-ichi Hanada, Jonathan W. Yewdell and James C. Yang
Nature 427, 252–256
(15 January 2004); doi:10.1038/nature02240
| First Paragraph | Full Text (HTML / PDF) |
news and views
Immunology: Protein surgery
Hans-Georg Rammensee
Nature 427, 203–204
(15 January 2004); doi:10.1038/427203a
| Full Text (HTML / PDF) |
letters to nature
Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP
Sharon A. Matheny, Chiyuan Chen, Robert L. Kortum, Gina L. Razidlo, Robert E. Lewis and Michael A. White
Nature 427, 256–260
(15 January 2004); doi:10.1038/nature02237
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letters to nature
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
Sven-Eric Jordt, Diana M. Bautista, Huai-hu Chuang, David D. McKemy, Peter M. Zygmunt, Edward D. Högestätt, Ian D. Meng and David Julius
Nature 427, 260–265
(15 January 2004); doi:10.1038/nature02282
| First Paragraph | Full Text (HTML / PDF) |
letter
Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway
Angeles Almeida, Salvador Moncada and Juan P. Bolaños
Nature Cell Biology 6, 45–51
(January 2004); doi:10.1038/ncb1080
| First Paragraph | Full Text (HTML/PDF) |
news and views
No glial death with NO
Solomon H. Snyder and Sangwon Kim
Nature Cell Biology 6, 17–18
(January 2004); doi:10.1038/ncb0104-17
| Full Text (HTML/PDF) |
letter
Polycomb CBX7 has a unifying role in cellular lifespan
Jesús Gil, David Bernard, Dolores Martínez and David Beach
Nature Cell Biology 6, 67–72
(January 2004); doi:10.1038/ncb1077
| First Paragraph | Full Text (HTML/PDF) |
review article
Tubby proteins: the plot thickens
Kilpatrick Carroll, Carlos Gomez and Lawrence Shapiro
Nature Reviews Molecular Cell Biology 5, 55–64
(January 2004); doi:10.1038/nrm1278
| Abstract | Full Text (HTML / PDF) |
article
High expression of active CDK6 in the cytoplasm of CD8 memory cells favors rapid division
Henrique Veiga-Fernandes and Benedita Rocha
Nature Immunology 5, 31–37
(January 2004); doi:10.1038/ni1015
| Abstract | Full Text (HTML/PDF) |
article
Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-γ and RelA
Denise Kelly, Jamie I Campbell, Timothy P King, George Grant, Emmelie A Jansson, Alistair G P Coutts, Sven Pettersson and Shaun Conway
Nature Immunology 5, 104–112
(January 2004); doi:10.1038/ni1018
| Abstract | Full Text (HTML/PDF) |
news and views
ComPPARtmentalizing NF-kB in the gut
Amer A Beg
Nature Immunology 5, 14–16
(January 2004); doi:10.1038/ni0104-14
| Full Text (HTML/PDF) |
review article
The human model: a genetic dissection of immunity to infection in natural conditions
Jean-Laurent Casanova and Laurent Abel
Nature Reviews Immunology 4, 55–66
(January 2004); doi:10.1038/nri1264
| Abstract | Full Text (HTML / PDF) |
perspectives
Innovation: T-cell development made simple
Juan Carlos Zúñiga-Pflücker
Nature Reviews Immunology 4, 67–72
(January 2004); doi:10.1038/nri1257
| Abstract | Full Text (HTML / PDF) |
article
Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells
Tianhong Wang, Guilian Niu, Marcin Kortylewski, Lyudmila Burdelya, Kenneth Shain, Shumin Zhang, Raka Bhattacharya, Dmitry Gabrilovich, Richard Heller, Domenico Coppola, William Dalton, Richard Jove, Drew Pardoll and Hua Yu
Nature Medicine 10, 48–54
(January 2004); doi:10.1038/nm976
| Abstract | Full Text (HTML/PDF) |
article
Overexpression of CNP in chondrocytes rescues achondroplasia through a MAPK-dependent pathway
Akihiro Yasoda, Yasato Komatsu, Hideki Chusho, Takashi Miyazawa, Ami Ozasa, Masako Miura, Tatsuya Kurihara, Tomohiro Rogi, Shoji Tanaka, Michio Suda, Naohisa Tamura, Yoshihiro Ogawa and Kazuwa Nakao
Nature Medicine 10, 80–86
(January 2004); doi:10.1038/nm971
| Abstract | Full Text (HTML/PDF) |
news and views
Learning to take a deep breath—with BDNF
George B Richerson and John M Bekkers
Nature Medicine 10, 25–26
(January 2004); doi:10.1038/nm0104-25
| Full Text (HTML/PDF) |
review article
Cytokines in cancer pathogenesis and cancer therapy
Glenn Dranoff
Nature Reviews Cancer 4, 11–22
(January 2004); doi:10.1038/nrc1252
| Abstract | Full Text (HTML / PDF) |
article
Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53
Hiroshi Katayama, Kaori Sasai, Hidehiko Kawai, Zhi-Min Yuan, Jolanta Bondaruk, Fumio Suzuki, Satoshi Fujii, Ralph B Arlinghaus, Bogdan A Czerniak and Subrata Sen
Nature Genetics 36, 55–62
(January 2004); doi:10.1038/ng1279
| Abstract | Full Text (HTML/PDF) |
letter
Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice
Geng Liu, John M Parant, Gene Lang, Patty Chau, Arturo Chavez-Reyes, Adel K El-Naggar, Asha Multani, Sandy Chang and Guillermina Lozano
Nature Genetics 36, 63–68
(January 2004); doi:10.1038/ng1282
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news and views
Conquering the complexity of p53
Laura D Attardi and Ronald A DePinho
Nature Genetics 36, 7–8
(January 2004); doi:10.1038/ng0104-7
| Full Text (HTML/PDF) |
review article
The neurobiology of nicotine addiction: bridging the gap from molecules to behaviour
Steven R. Laviolette and Derek van der Kooy
Nature Reviews Neuroscience 5, 55–65
(January 2004); doi:10.1038/nrn1298
| Abstract | Full Text (HTML / PDF) |
article
Gaining confidence in high-throughput protein interaction networks
Joel S Bader, Amitabha Chaudhuri, Jonathan M Rothberg & John Chant
Nature Biotechnology 22, 78–85
(14 December 2003); doi:10.1038/nbt924
| Abstract |
| Full Text (HTML/PDF) |
news and views
Protein interaction maps on the fly
Peter Uetz & Michael J Pankratz
Nature Biotechnology 22, 43–44
(January 2004); doi:10.1038/nbt0104-43
| Full Text (HTML/PDF) |
review article
The IKK NF-kB system: a treasure trove for drug development
Michael Karin, Yumi Yamamoto and Q. May Wang
Nature Reviews Drug Discovery 3, 17–26
(January 2004); doi:10.1038/nrd1279
| Abstract | Full Text (HTML / PDF) |
article
A mechanical unfolding intermediate in an actin-crosslinking protein
Ingo Schwaiger, Angelika Kardinal, Michael Schleicher, Angelika A Noegel & Matthias Rief
Nature Structural and Molecular Biology 11, 81–85
(29 December 2003); doi:10.1038/nsmb705
| Abstract |
| Full Text (HTML/PDF) |
news and views
Taking Drosophila Rad51 for a SPiN
Sarah J Radford & Jeff J Sekelsky
Nature Structural and Molecular Biology 11, 9–10
(January 2004); doi:10.1038/nsmb0104-9
| Abstract |
Full Text (HTML/PDF) |
article
X-ray structure of a protein-conducting channel
Bert van den Berg, William M. Clemons Jr, Ian Collinson, Yorgo Modis, Enno Hartmann, Stephen C. Harrison and Tom A. Rapoport
Nature 427, 36–44
(01 January 2004); doi:10.1038/nature02218
| Abstract | Full Text (HTML / PDF) |
news and views
Cell biology: Shape-shifting protein channel
Jordi Benach and John F. Hunt
Nature 427, 24–26
(01 January 2004); doi:10.1038/427024a
| Full Text (HTML / PDF) |
letters to nature
Defects in RGS9 or its anchor protein R9AP in patients with slow photoreceptor deactivation
Koji M. Nishiguchi, Michael A. Sandberg, Aart C. Kooijman, Kirill A. Martemyanov, Jan W. R. Pott, Stephanie A. Hagstrom, Vadim Y. Arshavsky, Eliot L. Berson and Thaddeus P. Dryja
Nature 427, 75–78
(01 January 2004); doi:10.1038/nature02170
| First Paragraph | Full Text (HTML / PDF) |
news and views
Vision: The need for speed
Kendall J. Blumer
Nature 427, 20–21
(01 January 2004); doi:10.1038/427020a
| Full Text (HTML / PDF) |
letters to nature
Expression and function of orphan nuclear receptor TLX in adult neural stem cells
Yanhong Shi, D. Chichung Lie, Philippe Taupin, Kinichi Nakashima, Jasodhara Ray, Ruth T. Yu, Fred H. Gage and Ronald M. Evans
Nature 427, 78–83
(01 January 2004); doi:10.1038/nature02211
| First Paragraph | Full Text (HTML / PDF) |
article
Notch activity acts as a sensor for extracellular calcium during vertebrate left-right determination
Ángel Raya, Yasuhiko Kawakami, Concepción Rodríguez-Esteban, Marta Ibañes, Diego Rasskin-Gutman, Joaquín Rodríguez-León, Dirk Büscher, José A. Feijó and Juan Carlos Izpisúa Belmonte
Nature 427, 121–128
(08 January 2004); doi:10.1038/nature02190
| Abstract | Full Text (HTML / PDF) |
news and views
Developmental biology: Asymmetric fixation
Nick Monk
Nature 427, 111–112
(08 January 2004); doi:10.1038/427111a
| Full Text (HTML / PDF) |
letters to nature
T-cell priming by dendriticcells in lymph nodes occurs in three distinct phases
Thorsten R. Mempel, Sarah E. Henrickson and Ulrich H. von Andrian
Nature 427, 154–159
(08 January 2004); doi:10.1038/nature02238
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Vernalization in Arabidopsis thaliana is mediated by the PHD finger protein VIN3
Sibum Sung and Richard M. Amasino
Nature 427, 159–164
(08 January 2004); doi:10.1038/nature02195
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letters to nature
Vernalization requires epigenetic silencing of FLC by histone methylation
Ruth Bastow, Joshua S. Mylne, Clare Lister, Zachary Lippman, Robert A. Martienssen and Caroline Dean
Nature 427, 164–167
(08 January 2004); doi:10.1038/nature02269
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Plant development: The flowers that bloom in the spring
Christopher Surridge
Nature 427, 112
(08 January 2004); doi:10.1038/427112a
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letters to nature
Bcl10 activates the NF-kB pathway through ubiquitination of NEMO
Honglin Zhou, Ingrid Wertz, Karen O'Rourke, Mark Ultsch, Somasekar Seshagiri, Michael Eby, Wei Xiao and Vishva M. Dixit
Nature 427, 167–171
(08 January 2004); doi:10.1038/nature02273
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letters to nature
Vinculin activation by talin through helical bundle conversion
Tina Izard, Gwyndaf Evans, Robert A. Borgon, Christina L. Rush, Gerard Bricogne and Philippe R. J. Bois
Nature 427, 171–175
(08 January 2004); doi:10.1038/nature02281
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Cancer: Guarding the guardian?
Henning F. Horn and Karen H. Vousden
Nature 427, 110–111
(08 January 2004); doi:10.1038/427110a
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article
Mammalian formin-1 participates in adherens junctions and polymerization of linear actin cables
Agnieszka Kobielak, H. Amalia Pasolli and Elaine Fuchs
Nature Cell Biology 6, 21–30
(January 2004); doi:10.1038/ncb1075
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Formin' adherens junctions
Sally Zigmond
Nature Cell Biology 6, 12–14
(January 2004); doi:10.1038/ncb0104-12
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review article
Plant cell biology: Microtubules and the shape of plants to come
Clive Lloyd and Jordi Chan
Nature Reviews Molecular Cell Biology 5, 13–23
(January 2004); doi:10.1038/nrm1277
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article
The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens
You-Wen He, Hong Li, Jun Zhang, Chia-Lin Hsu, Emily Lin, Nu Zhang, Jian Guo, Katherine A Forbush and Michael J Bevan
Nature Immunology 5, 88–97
(January 2004); doi:10.1038/ni1021
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Mindin the fort
Christine McDonald and Gabriel Nuñez
Nature Immunology 5, 16–18
(January 2004); doi:10.1038/ni0104-16
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review article
Lymphatic vasculature development
Guillermo Oliver
Nature Reviews Immunology 4, 35–45
(January 2004); doi:10.1038/nri1258
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article
Suppression of breast cancer by chemical modulation of vulnerable zinc fingers in estrogen receptor
Li Hua Wang, Xiao Yi Yang, Xiaohu Zhang, Kelly Mihalic, Ying-Xin Fan, Weihua Xiao, O M Zack Howard, Ettore Appella, Andrew T Maynard and William L Farrar
Nature Medicine 10, 40–47
(January 2004); doi:10.1038/nm969
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article
Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis
Scott T Avecilla, Koichi Hattori, Beate Heissig, Rafael Tejada, Fang Liao, Koji Shido, David K Jin, Sergio Dias, Fan Zhang, Travis E Hartman, Neil R Hackett, Ronald G Crystal, Larry Witte, Daniel J. Hicklin, Peter Bohlen, Dan Eaton, David Lyden, Fredric de Sauvage and Shahin Rafii
Nature Medicine 10, 64–71
(January 2004); doi:10.1038/nm973
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Notch, the new muscle booster
Charlotte Schubert
Nature Medicine 10, 24
(January 2004); doi:10.1038/nm0104-24
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review article
Prevention of non-melanoma skin cancer by targeting ultraviolet-B-light signalling
G. Tim Bowden
Nature Reviews Cancer 4, 23–35
(January 2004); doi:10.1038/nrc1253
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letter
The B-cell maturation factor Blimp-1 specifies vertebrate slow-twitch muscle fiber identity in response to Hedgehog signaling
Sarah Baxendale, Claire Davison, Claire Muxworthy, Christian Wolff, Philip W Ingham and Sudipto Roy
Nature Genetics 36, 88–93
(January 2004); doi:10.1038/ng1280
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White meat or dark?
Ava E Brent and Clifford J Tabin
Nature Genetics 36, 8–10
(January 2004); doi:10.1038/ng0104-8
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article
Synaptic signaling between GABAergic interneurons and oligodendrocyte precursor cells in the hippocampus
Shih-chun Lin and Dwight E Bergles
Nature Neuroscience 7, 24–32
(January 2004); doi:10.1038/nn1162
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article
Hippocampal plasticity requires postsynaptic ephrinBs
Ilona C Grunwald, Martin Korte, Giselind Adelmann, Anne Plueck, Klas Kullander, Ralf H Adams, Michael Frotscher, Tobias Bonhoeffer and Rüdiger Klein
Nature Neuroscience 7, 33–40
(January 2004); doi:10.1038/nn1164
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article
PIP2 increases the speed of response of synaptotagmin and steers its membrane-penetration activity toward the plasma membrane
Jihong Bai, Ward C Tucker & Edwin R Chapman
Nature Structural & Molecular Biology 11, 36–44
(January 2004); doi:10.1038/nsmb709
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E3 ligase activity and suppression of breast cancer
Angela K Eggleston
Nature Structural & Molecular Biology 11, 8–9
(January 2004); doi:10.1038/nsmb0104-8
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