The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.
Click here for free access to the 'Featured Articles' section, with new articles every week.
letters to nature Regulation of ethylene gas biosynthesis by the Arabidopsis ETO1 protein
Kevin L.-C. Wang , Hitoshi Yoshida , Claire Lurin and Joseph R. Ecker Nature428, 945–950
(29 April 2004); doi:10.1038/nature02516
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letters to nature Cadherin 23 is a component of the tip link in hair-cell stereocilia
Jan Siemens, Concepcion Lillo, Rachel A. Dumont, Anna Reynolds, David S. Williams, Peter G. Gillespie and Ulrich Müller Nature428, 950–955
(29 April 2004); doi:10.1038/nature02483
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letters to nature Mutations in cadherin 23 affect tip links in zebrafish sensory hair cells
Christian Söllner, Gerd-Jörg Rauch, Jan Siemens, Robert Geisler, Stephan C. Schuster, the Tübingen 2000 Screen Consortium, Ulrich Müller and Teresa Nicolson Nature428, 955–959
(29 April 2004); doi:10.1038/nature02484
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news and views Hearing: Tightrope act
David P. Corey and Marcos Sotomayor Nature428, 901–903
(29 April 2004); doi:10.1038/428901a
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letters to nature Splicing of oskar RNA in the nucleus is coupled to its cytoplasmic localization
Olivier Hachet and Anne Ephrussi Nature428, 959–963
(29 April 2004); doi:10.1038/nature02521
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letter Gating of CFTR by the STAS domain of SLC26 transporters
Shigeru B.H. Ko, Weizhong Zeng, Michael R. Dorwart, Xiang Luo, Kil Hwan Kim, Linda Millen, Hidemi Goto, Satoru Naruse, Abigail Soyombo, Philip J. Thomas and Shmuel Muallem Nature Cell Biology6, 343–350
(April 2004); doi:10.1038/ncb1115
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news and views Bicarbonate secretion: it takes two to tango
Michael A. Gray Nature Cell Biology6, 292–294
(April 2004); doi:10.1038/ncb0404-292
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news and views New neurons?
Jack Horne Nature Cell Biology6, 287
(April 2004); doi:10.1038/ncb0404-287
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perspectives Opinion: The biogenesis of multivesicular endosomes
Jean Gruenberg and Harald Stenmark Nature Reviews Molecular Cell Biology5, 317–323
(April 2004); doi:10.1038/nrm1360
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article Fas ligation on macrophages enhances IL-1R1-Toll-like receptor 4 signaling and promotes chronic inflammation
Yingyu Ma, Hongtao Liu, Hoang Tu-Rapp, Hans-Juergen Thiesen, Saleh M Ibrahim, Shawn M Cole and Richard M Pope Nature Immunology5, 380–387
(April 2004); doi:10.1038/ni1054
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article Continued maturation of thymic emigrants in the periphery
Tamar E Boursalian, Jonathan Golob, David M Soper, Cristine J Cooper and Pamela J Fink Nature Immunology5, 418–425
(April 2004); doi:10.1038/ni1049
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review article Membranes as messengers in T cell adhesion signaling
Michael L Dustin, Trever G Bivona and Mark R Philips Nature Immunology5, 363–372
(April 2004); doi:10.1038/ni1057
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review article Feedback regulation of lymphocyte signalling
Michael Reth and Tilman Brummer Nature Reviews Immunology4, 269–278
(April 2004); doi:10.1038/nri1335
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letter Human lupus T cells resist inactivation and escape death by upregulating COX-2
Luting Xu, Li Zhang, Yajun Yi, Hee-Kap Kang and Syamal K Datta Nature Medicine10, 411–415
(April 2004); doi:10.1038/nm1005
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news and views Sporadic ALS: blame it on the editor
Stuart A Lipton Nature Medicine10, 347
(April 2004); doi:10.1038/nm0404-347
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review article Molecular targets in pituitary tumours
Anthony P. Heaney and Shlomo Melmed Nature Reviews Cancer4, 285–295
(April 2004); doi:10.1038/nrc1320
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perspectives Timeline: The evolution of thalidomide and its IMiD derivatives as anticancer agents
J. Blake Bartlett, Keith Dredge and Angus G. Dalgleish Nature Reviews Cancer4, 314–322
(April 2004); doi:10.1038/nrc1323
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article Rb regulates proliferation and rod photoreceptor development in the mouse retina
Jiakun Zhang, Jonathan Gray, Lizhao Wu, Gustavo Leone, Sheldon Rowan, Constance L Cepko, Xuemei Zhu, Cheryl M Craft and Michael A Dyer Nature Genetics36, 351–360
(April 2004); doi:10.1038/ng1318
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letter Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein
Giles D J Watts, Jill Wymer, Margaret J Kovach, Sarju G Mehta, Steven Mumm, Daniel Darvish, Alan Pestronk, Michael P Whyte and Virginia E Kimonis Nature Genetics36, 377–381
(April 2004); doi:10.1038/ng1332
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letter Mutations in VPS33B, encoding a regulator of SNARE-dependent membrane fusion, cause arthrogryposis-renal dysfunction-cholestasis (ARC) syndrome
Paul Gissen, Colin A Johnson, Neil V Morgan, Janneke M Stapelbroek, Tim Forshew, Wendy N Cooper, Patrick J McKiernan, Leo W J Klomp, Andrew A M Morris, James E Wraith, Patricia McClean, Sally A Lynch, Richard J Thompson, Bryan Lo, Oliver W Quarrell, Maja Di Rocco, Richard C Trembath, Hanna Mandel, S Wali, Fiona E Karet, A S Knisely, Roderick H J Houwen, Deirdre A Kelly and Eamonn R Maher Nature Genetics36, 400–404
(April 2004); doi:10.1038/ng1325
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news and views A plethora of sites
Ghia Euskirchen and Michael Snyder Nature Genetics36, 325–326
(April 2004); doi:10.1038/ng0404-325
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article The X-linked mental retardation protein oligophrenin-1 is required for dendritic spine morphogenesis
Eve-Ellen Govek, Sarah E Newey, Colin J Akerman, Justin R Cross, Lieven Van der Veken and Linda Van Aelst Nature Neuroscience7, 364–372
(April 2004); doi:10.1038/nn1210
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research article Reversible site-selective labeling of membrane proteins in live cells
Emmanuel G Guignet, Ruud Hovius and Horst Vogel Nature Biotechnology22, 440–444
(April 2004); doi:10.1038/nbt954
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news and views Finding needles in haystacks
Jonathan A Javitch Nature Biotechnology22, 394–396
(April 2004); doi:10.1038/nbt0404-394
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review article Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia
Bryan L. Roth, Douglas J. Sheffler & Wesley K. Kroeze Nature Reviews Drug Discovery3, 353–359
(April 2004); doi:10.1038/nrd1346
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article Structural basis of sugar-recognizing ubiquitin ligase
Tsunehiro Mizushima, Takeshi Hirao, Yukiko Yoshida, Soo Jae Lee, Tomoki Chiba, Kazuhiro Iwai, Yoshiki Yamaguchi, Koichi Kato, Tomitake Tsukihara and Keiji Tanaka Nature Structural and Molecular Biology11, 365–370
(April 2004); doi:10.1038/nsmb732
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review article Cell-cycle progression and the gerneration of asymmetry in Caulobacter Crescentus
Jeffrey M. Skerker & Michael T. Laub Nature Reviews Microbiology2, 325–337
(April 2004); doi:10.1038/nrmicro864
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article GADD45β/GADD45γ and MEKK 4 comprise a genetic pathway mediating STAT4-independent IFN-γ production in T cells
Hongbo Chi, Binfeng Lu, Mutsuhiro Takekawa, Roger J Davis and Richard A Flavell EMBO journal23, 1576–1586
(April 2004); doi: 10.1038/sj.emboj.7600173
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letters to nature Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges
Sarah M. Webster, Donato del Camino, John P. Dekker and Gary Yellen Nature428, 864–868
(22 April 2004); doi:10.1038/nature02468
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letters to nature Programmed population control by cell-cell communication and regulated killing
Lingchong You, Robert Sidney Cox III, Ron Weiss and Frances H. Arnold Nature428, 868–871
(22 April 2004); doi:10.1038/nature02491
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news and views Cancer: Enzymes play molecular tag
Deborah K. Morrison Nature428, 813–815
(22 April 2004); doi:10.1038/428813a
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article Delivery of raft-associated, GPI-anchored proteins to the apical surface of polarized MDCK cells by a transcytotic pathway
Roman Polishchuk, Alessio Di Pentima and Jennifer Lippincott-Schwartz Nature Cell Biology6, 297–307
(April 2004); doi:10.1038/ncb1109
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news and views Unravelling protein sorting
W. James Nelson and Enrique Rodriguez-Boulan Nature Cell Biology6, 282–284
(April 2004); doi:10.1038/ncb0404-282
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letter Dynamin 2 binds γ-tubulin and participates in centrosome cohesion
Heather M. Thompson, Hong Cao, Jing Chen, Ursula Euteneuer and Mark A. McNiven Nature Cell Biology6, 335–342
(April 2004); doi:10.1038/ncb1112
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review article Plant cell biology: Controlled cell death, plant survival and development
Eric Lam Nature Reviews Molecular Cell Biology5, 305–315
(April 2004); doi:10.1038/nrm1358
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article ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance
Elizabeth K Brint, Damo Xu, Haiying Liu, Aisling Dunne, Andrew N J McKenzie, Luke A J O'Neill and Foo Y Liew Nature Immunology5, 373–379
(April 2004); doi:10.1038/ni1050
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article Locomotion of monocytes on endothelium is a critical step during extravasation
Alan R Schenkel, Zahra Mamdouh and William A Muller Nature Immunology5, 393–400
(April 2004); doi:10.1038/ni1051
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news and views Crawling and INTEGRating apical cues
Ronen Alon and Francis W Luscinskas Nature Immunology5, 351–353
(April 2004); doi:10.1038/ni0404-351
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review article Developing a new paradigm for thymus organogenesis
C. Clare Blackburn and Nancy R. Manley Nature Reviews Immunology4, 278–289
(April 2004); doi:10.1038/nri1331
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review article Immunotherapeutic uses of CpG oligodeoxynucleotides
Dennis M. Klinman Nature Reviews Immunology4, 249–259
(April 2004); doi:10.1038/nri1329
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brief communication Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease
Vicente E Torres, Xiaofang Wang, Qi Qian, Stefan Somlo, Peter C Harris, Vincent H Gattone and II Nature Medicine10, 363–364
(April 2004); doi:10.1038/nm1004
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letter Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways
Harry Björkbacka, Vidya V Kunjathoor, Kathryn J Moore, Stephanie Koehn, Christine M Ordija, Melinda A Lee, Terry Means, Kristen Halmen, Andrew D Luster, Douglas T Golenbock and Mason W Freeman Nature Medicine10, 416–421
(April 2004); doi:10.1038/nm1008
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review article Tracing the network connecting brca and fanconi anaemia proteins
Ashok R. Venkitaraman Nature Reviews Cancer4, 266–276
(April 2004); doi:10.1038/nrc1321
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brief communication A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes
Nunzio Bottini, Lucia Musumeci, Andres Alonso, Souad Rahmouni, Konstantina Nika, Masoud Rostamkhani, James MacMurray, Gian Franco Meloni, Paola Lucarelli, Maurizio Pellecchia, George S Eisenbarth, David Comings and Tomas Mustelin Nature Genetics36, 337–338
(April 2004); doi:10.1038/ng1323
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letter Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1)
Päivi Pajukanta, Heidi E Lilja, Janet S Sinsheimer, Rita M Cantor, Aldons J Lusis, Massimiliano Gentile, Xiaoqun Joyce Duan, Aino Soro-Paavonen, Jussi Naukkarinen, Janna Saarela, Markku Laakso, Christian Ehnholm, Marja-Riitta Taskinen and Leena Peltonen Nature Genetics36, 371–376
(April 2004); doi:10.1038/ng1320
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news and views USF1 on trial
Carol C Shoulders Nature Genetics36, 322–323
(April 2004); doi:10.1038/ng0404-322
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article Tenascin-R mediates activity-dependent recruitment of neuroblasts in the adult mouse forebrain
Armen Saghatelyan, Antoine de Chevigny, Melitta Schachner and Pierre-Marie Lledo Nature Neuroscience7, 347–356
(April 2004); doi:10.1038/nn1211
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review article Src kinases: a hub for NMDA receptor regulation
Michael W. Salter and Lorraine V. Kalia Nature Reviews Neuroscience5, 317–328
(April 2004); doi:10.1038/nrn1368
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research article The plasma membrane-bound phospholipase Dd enhances freezing tolerance in Arabidopsis thaliana
Weiqi Li, Maoyin Li, Wenhua Zhang, Ruth Welti and Xuemin Wang Nature Biotechnology22, 427–433
(April 2004); doi:10.1038/nbt949
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research article Differential quantitative analysis of MHC ligands by mass spectrometry using stable isotope labeling
Claudia Lemmel, Steffen Weik, Ute Eberle, Jörn Dengjel, Thomas Kratt, Horst-Dieter Becker, Hans-Georg Rammensee and Stefan Stevanovic; Nature Biotechnology22, 450–454
(April 2004); doi:10.1038/nbt947
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review article siRNAs: applications in functional genomics and potential as therapeutics
Yair Dorsett and Thomas Tuschl Nature Reviews Drug Discovery3, 318–329
(April 2004); doi:10.1038/nrd1345
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brief communication A receptor for green tea polyphenol EGCG
Hirofumi Tachibana, Kiyoshi Koga, Yoshinori Fujimura and Koji Yamada Nature Structural and Molecular Biology11, 380–381
(April 2004); doi:10.1038/nsmb743
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meeting report Calcineurin: a central controller of signalling in eukaryotes
José Aramburu, Joseph Heitman & Gerald R. Crabtree EMBO reports11, 343–348
(April 2004); doi:10.1038/sj.embor.7400133
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letters to nature The endothelial-cell-derived secreted factor Egfl7 regulates vascular tube formation
Leon H. Parker, Maike Schmidt, Suk-Won Jin, Alane M. Gray, Dimitris Beis, Thinh Pham, Gretchen Frantz, Susan Palmieri, Kenneth Hillan, Didier Y. R. Stainier, Frederic J. de Sauvage and Weilan Ye Nature428, 754–758
(15 April 2004); doi:10.1038/nature02416
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letters to nature Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis
Takako Koga , Masanori Inui, Kazuya Inoue, Sunhwa Kim, Ayako Suematsu, Eiji Kobayashi, Toshio Iwata, Hiroshi Ohnishi, Takashi Matozaki, Tatsuhiko Kodama, Tadatsugu Taniguchi, Hiroshi Takayanagi and Toshiyuki Takai Nature428, 758–763
(15 April 2004); doi:10.1038/nature02444
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letters to nature Bacterial disease resistance in Arabidopsis through flagellin perception
Cyril Zipfel, Silke Robatzek, Lionel Navarro, Edward J. Oakeley, Jonathan D. G. Jones, Georg Felix and Thomas Boller Nature428, 764–767
(15 April 2004); doi:10.1038/nature02485
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letters to nature Cdc42 and mDia3 regulate microtubule attachment to kinetochores
Shingo Yasuda, Fabian Oceguera-Yanez, Takayuki Kato, Muneo Okamoto, Shigenobu Yonemura, Yasuhiko Terada, Toshimasa Ishizaki and Shuh Narumiya Nature428, 767–771
(15 April 2004); doi:10.1038/nature02452
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news and views Cancer: Kip moving
John G. Collard Nature428, 705–708
(15 April 2004); doi:10.1038/428705a
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article A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells
Elizabeth Yeh, Melissa Cunningham, Hugh Arnold, Dawn Chasse, Teresa Monteith, Giovanni Ivaldi, William C. Hahn, P. Todd Stukenberg, Shirish Shenolikar, Takafumi Uchida, Christopher M. Counter, Joseph R. Nevins, Anthony R. Means and Rosalie Sears Nature Cell Biology6, 308–318
(April 2004); doi:10.1038/ncb1110
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news and views PINning down the c-Myc oncoprotein
David Dominguez-Sola and Riccardo Dalla-Favera Nature Cell Biology6, 288–289
(April 2004); doi:10.1038/ncb0404-288
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letter Role of the PAR-3-KIF3 complex in the establishment of neuronal polarity
Takashi Nishimura, Katsuhiro Kato, Tomoya Yamaguchi, Yuko Fukata, Shigeo Ohno and Kozo Kaibuchi Nature Cell Biology6, 328–334
(April 2004); doi:10.1038/ncb1118
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review article Biology, structure and mechanism of P-type ATPases
Werner Kühlbrandt Nature Reviews Molecular Cell Biology5, 282–295
(April 2004); doi:10.1038/nrm1354
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article Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway
Christopher L Karp, Leah M Flick, Kiwon W Park, Samir Softic, Todd M Greer, Raquel Keledjian, Rong Yang, Jasim Uddin, William B Guggino, Sowsan F Atabani, Yasmine Belkaid, Yan Xu, Jeffrey A Whitsett, Frank J Accurso, Marsha Wills-Karp and Nicos A Petasis Nature Immunology5, 388–392
(April 2004); doi:10.1038/ni1056
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news and views New therapeutic key for cystic fibrosis: a role for lipoxins
Daiya Takai, Takahide Nagase and Takao Shimizu Nature Immunology5, 357–358
(April 2004); doi:10.1038/ni0404-357
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review article Acquired and natural memory T cells join forces at the mucosal front line
Hilde Cheroutre and Loui Madakamutil Nature Reviews Immunology4, 290–300
(April 2004); doi:10.1038/nri1333
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article A new role for Nogo as a regulator of vascular remodeling
Lisette Acevedo, Jun Yu, Hediye Erdjument-Bromage, Robert Qing Miao, Ji-Eun Kim, David Fulton, Paul Tempst, Stephen M Strittmatter and William C Sessa Nature Medicine10, 382–388
(April 2004); doi:10.1038/nm1020
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news and views Nogo puts the brake on vascular lesions
Elaine W Raines Nature Medicine10, 348–349
(April 2004); doi:10.1038/nm0404-348
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news and views Cocaine's long run
Pietro Paolo Sanna and George F Koob Nature Medicine10, 340–341
(April 2004); doi:10.1038/nm0404-340
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review article The pathobiology of mucositis
Stephen T. Sonis Nature Reviews Cancer4, 277–284
(April 2004); doi:10.1038/nrc1318
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news and views Shutting down Wnt signal-activated cancer
M Mark Taketo Nature Genetics36, 320–322
(April 2004); doi:10.1038/ng0404-320
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letter Mutations in the gene encoding filamin B disrupt vertebral segmentation, joint formation and skeletogenesis
Deborah Krakow, Stephen P Robertson, Lily M King, Timothy Morgan, Eiman T Sebald, Cristina Bertolotto, Sebastian Wachsmann-Hogiu, Dora Acuna, Sandor S Shapiro, Toshiro Takafuta, Salim Aftimos, Chong Ae Kim, Helen Firth, Carlos E Steiner, Valerie Cormier-Daire, Andrea Superti-Furga, Luisa Bonafe, John M Graham, Jr Arthur Grix, Carlos A Bacino, Judith Allanson, Martin G Bialer, Ralph S Lachman, David L Rimoin and Daniel H Cohn Nature Genetics36, 405–410
(April 2004); doi:10.1038/ng1319
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news and views Phenotype matters
Leslie G Biesecker Nature Genetics36, 323–324
(April 2004); doi:10.1038/ng0404-323
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brief communication Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system
Wei Fan, Kate L J Ellacott, Ilia G Halatchev, Kanji Takahashi, Pinxuan Yu and Roger D Cone Nature Neuroscience7, 335–336
(April 2004); doi:10.1038/nn1214
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review article Neural activity and the dynamics of central nervous system development
Jackie Yuanyuan Hua and Stephen J Smith Nature Neuroscience7, 327–332
(April 2004); doi:10.1038/nn1218
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research article Capturing and profiling adult hair follicle stem cells
Rebecca J Morris, Yaping Liu, Lee Marles, Zaixin Yang, Carol Trempus, Shulan Li, Jamie S Lin, Janet A Sawicki and George Cotsarelis Nature Biotechnology22, 411–417
(April 2004); doi:10.1038/nbt950
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news and views Profiling epithelial stem cells
Paul A Khavari Nature Biotechnology22, 393–394
(April 2004); doi:10.1038/nbt0404-393
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review article Small-molecule inhibitors of protein-protein interactions: progressing towards the dream
Michelle R. Arkin and James A. Wells Nature Reviews Drug Discovery3, 301–317
(April 2004); doi:10.1038/nrd1343
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article Regulation of the p300 HAT domain via a novel activation loop
Paul R Thompson, Dongxia Wang, Ling Wang, Marcella Fulco, Natalia Pediconi, Dianzheng Zhang, Woojin An, Qingyuan Ge, Robert G Roeder, Jiemin Wong, Massimo Levrero, Vittorio Sartorelli, Robert J Cotter and Philip A Cole Nature Structural and Molecular Biology11, 308–315
(April 2004); doi:10.1038/nsmb740
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news and views Is acetylation the key to opening locked gates?
B Franklin Pugh Nature Structural and Molecular Biology11, 298–300
(April 2004); doi:10.1038/nsmb0404-298
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letters to nature IkB kinase-α acts in the epidermis to control skeletal and craniofacial morphogenesis
Alok K. Sil, Shin Maeda, Yuji Sano, Dennis R. Roop and Michael Karin Nature428, 660–664
(08 April 2004); doi:10.1038/nature02421
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letters to nature Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts
Charles E. Murry, Mark H. Soonpaa, Hans Reinecke, Hidehiro Nakajima, Hisako O. Nakajima, Michael Rubart, Kishore B. S. Pasumarthi, Jitka Ismail Virag, Stephen H. Bartelmez, Veronica Poppa, Gillian Bradford, Joshua D. Dowell, David A. Williams and Loren J. Field Nature428, 664–668
(08 April 2004); doi:10.1038/nature02446
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letters to nature Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium
Leora B. Balsam, Amy J. Wagers, Julie L. Christensen, Theo Kofidis, Irving L. Weissman and Robert C. Robbins Nature428, 668–673
(08 April 2004); doi:10.1038/nature02460
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news and views Stem cells: Lost in translation
Kenneth R. Chien Nature428, 607–608
(08 April 2004); doi:10.1038/nature02500
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news and views Cell biology: Competitive edge
Amanda Tromans Nature428, 609
(08 April 2004); doi:10.1038/428609a
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letter PKB/Akt modulates TGF-β signalling through a direct interaction with Smad3
Ingrid Remy, Annie Montmarquette and Stephen W. Michnick Nature Cell Biology6, 358–365
(April 2004); doi:10.1038/ncb1113
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letter Akt interacts directly with Smad3 to regulate the sensitivity to TGF-β-induced apoptosis
Andrew R. Conery, Yanna Cao, E. Aubrey Thompson, Courtney M. Townsend, Jr Tien C. Ko and Kunxin Luo Nature Cell Biology6, 366–372
(April 2004); doi:10.1038/ncb1117
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news and views Getting connected
Alison Schuldt Nature Cell Biology6, 281
(April 2004); doi:10.1038/ncb0404-281
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review article Working out the strength and flexibility of desmosomes
Spiro Getsios, Arthur C. Huen and Kathleen J. Green Nature Reviews Molecular Cell Biology5, 271–281
(April 2004); doi:10.1038/nrm1356
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article Distinct regions in the CD28 cytoplasmic domain are required for T helper type 2 differentiation
Pietro G Andres, Kimberly C Howland, Ajay Nirula, Lawrence P Kane, Luke Barron, Douglas Dresnek, Ali Sadra, John Imboden, Arthur Weiss and Abul K Abbas Nature Immunology5, 435–442
(April 2004); doi:10.1038/ni1044
| Abstract | Full Text (HTML/PDF) |
article Human thymic stromal lymphopoietin promotes dendritic cell-mediated CD4+ T cell homeostatic expansion
Norihiko Watanabe, Shino Hanabuchi, Vassili Soumelis, Wei Yuan, Stephen Ho, Rene de Waal Malefyt and Yong-Jun Liu Nature Immunology5, 426–434
(April 2004); doi:10.1038/ni1048
| Abstract | Full Text (HTML/PDF) |
review article Clinical islet transplantation: advances and immunological challenges
Camillo Ricordi and Terry B. Strom Nature Reviews Immunology4, 259–268
(April 2004); doi:10.1038/nri1332
| Abstract | Full Text (HTML / PDF) |
article CDC91L1 (PIG-U) is a newly discovered oncogene in human bladder cancer
Zhongmin Guo, Jürgen F. Linn, Guojun Wu, Sarah L Anzick, Claus F Eisenberger, Sarel Halachmi, Yoram Cohen, Alexey Fomenkov, Mohammad Obaidul Hoque, Kenji Okami, Gabriel Steiner, James M Engles, Motonabu Osada, Chulso Moon, Edward Ratovitski, Jeffrey M Trent, Paul S Meltzer, William H Westra, Lambertus A Kiemeney, Mark P Schoenberg, David Sidransky and Barry Trink Nature Medicine10, 374–381
(April 2004); doi:10.1038/nm1010
| Abstract | Full Text (HTML/PDF) |
news and views Embedding T cells in the matrix
Liisa K Selin and Markus Cornberg Nature Medicine10, 343–345
(April 2004); doi:10.1038/nm0404-343
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perspectives Opinion: Rules of evidence for cancer molecular-marker discovery and validation
David F. Ransohoff Nature Reviews Cancer4, 309–314
(April 2004); doi:10.1038/nrc1322
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article Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16Ink4a-p19Arf pathway
Dmitry V Bulavin, Crissy Phillips, Bonnie Nannenga, Oleg Timofeev, Larry A Donehower, Carl W Anderson, Ettore Appella and Albert J Fornace Jr. Nature Genetics36, 343–350
(April 2004); doi:10.1038/ng1317
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news and views Wip-ing out cancer
René Bernards Nature Genetics36, 319–320
(April 2004); doi:10.1038/ng0404-319
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perspectives Science and society: Shaping science policy in the age of genomics
Richard R. Sharp, Michael A. Yudell and Samuel H. Wilson Nature Reviews Genetics5, 311–315
(April 2004); doi:10.1038/nrg1320
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article Dopamine neurons release transmitter via a flickering fusion pore
Roland G W Staal, Eugene V Mosharov and David Sulzer Nature Neuroscience7, 341–346
(April 2004); doi:10.1038/nn1205
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news and views Synaptic vesicles really do kiss and run
R Mark Wightman and Christy L Haynes Nature Neuroscience7, 321–322
(April 2004); doi:10.1038/nn0404-321
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review article Genes and ligands for odorant, vomeronasal and taste receptors
Peter Mombaerts Nature Reviews Neuroscience5, 263–278
(April 2004); doi:10.1038/nrn1365
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news and views Unshackling expression profiling arrays
Darrell P Chandler Nature Biotechnology22, 396–397
(April 2004); doi:10.1038/nbt0404-396
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research article An improved cyan fluorescent protein variant useful for FRET
Mark A Rizzo, Gerald H Springer, Butch Granada and David W Piston Nature Biotechnology22, 445–449
(April 2004); doi:10.1038/nbt945
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review article Targeting IL-1 in inflammatory disease: new opportunities for therapeutic intervention
Martin Braddock and Anthony Quinn Nature Reviews Drug Discovery3, 330–340
(April 2004); doi:10.1038/nrd1342
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article The Mad2 spindle checkpoint protein has two distinct natively folded states
Xuelian Luo, Zhanyun Tang, Guohong Xia, Katja Wassmann, Tomohiro Matsumoto, Josep Rizo and Hongtao Yu Nature Structural and Molecular Biology11, 338–345
(April 2004); doi:10.1038/nsmb748
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letters to nature Differentiating germ cells can revert into functional stem cells in Drosophila melanogaster ovaries
Toshie Kai and Allan Spradling Nature428, 564–569
(01 April 2004); doi:10.1038/nature02436
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letters to nature AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
Yasuhiko Minokoshi, Thierry Alquier, Noboru Furukawa, Young-Bum Kim, Anna Lee, Bingzhong Xue, James Mu, Fabienne Foufelle, Pascal Ferré, Morris J. Birnbaum, Bettina J. Stuck and Barbara B. Kahn Nature428, 569–574
(01 April 2004); doi:10.1038/nature02440
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letters to nature From molecular noise to behavioural variability in a single bacterium
Ekaterina Korobkova, Thierry Emonet, Jose M. G. Vilar, Thomas S. Shimizu and Philippe Cluzel Nature428, 574–578
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review article Designing materials for biology and medicine
Robert Langer and David A. Tirrell Nature428, 487–492
(01 April 2004); doi:10.1038/nature02388
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letter Abi1 is essential for the formation and activation of a WAVE2 signalling complex
Metello Innocenti, Adriana Zucconi, Andrea Disanza, Emanuela Frittoli, Liliana B. Areces, Anika Steffen, Theresia E. B. Stradal, Pier Paolo Di Fiore, Marie-France Carlier and Giorgio Scita Nature Cell Biology6, 319–327
(April 2004); doi:10.1038/ncb1105
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news and views Solving the WAVE function
Simone L. Blagg and Robert H. Insall Nature Cell Biology6, 279–281
(April 2004); doi:10.1038/ncb0404-279
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letter SREBPs suppress IRS-2-mediated insulin signalling in the liver
Tomohiro Ide, Hitoshi Shimano, Naoya Yahagi, Takashi Matsuzaka, Masanori Nakakuki, Takashi Yamamoto, Yoshimi Nakagawa, Akimitsu Takahashi, Hiroaki Suzuki, Hirohito Sone, Hideo Toyoshima, Akiyoshi Fukamizu and Nobuhiro Yamada Nature Cell Biology6, 351–357
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review article Endothelial cell-cell junctions: happy together
Elisabetta Dejana Nature Reviews Molecular Cell Biology5, 261–270
(April 2004); doi:10.1038/nrm1357
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article Induction of T cell development and establishment of T cell competence from embryonic stem cells differentiated in vitro
Thomas M Schmitt, Renée F de Pooter, Matthew A Gronski, Sarah K Cho, Pamela S Ohashi and Juan Carlos Zúñga-Pflücker Nature Immunology5, 410–417
(April 2004); doi:10.1038/ni1055
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news and views From totipotency to T in a dish
Ellen V Rothenberg Nature Immunology5, 359–360
(April 2004); doi:10.1038/ni0404-359
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article The STAT3 isoforms α and β have unique and specific functions
Diego Maritano, Michelle L Sugrue, Silvia Tininini, Sarah Dewilde, Birgit Strobl, XinPing Fu, Victoria Murray-Tait, Roberto Chiarle and Valeria Poli Nature Immunology5, 401–409
(April 2004); doi:10.1038/ni1052
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perspectives Timeline: Jurkat T cells and development of the T-cell receptor signalling paradigm
Robert T. Abraham and Arthur Weiss Nature Reviews Immunology4, 301–308
(April 2004); doi:10.1038/nri1330
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article Neutralization of CD95 ligand promotes regeneration and functional recovery after spinal cord injury
Deana Demjen, Stefan Klussmann, Susanne Kleber, Cecilia Zuliani, Bram Stieltjes, Corinna Metzger, Ulrich A Hirt, Henning Walczak, Werner Falk, Marco Essig, Lutz Edler, Peter H Krammer and Ana Martin-Villalba Nature Medicine10, 389–395
(April 2004); doi:10.1038/nm1007
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news and views Spinal cord alive and kicking
Catherine Barthélémy and Christopher E Henderson Nature Medicine10, 339–340
(April 2004); doi:10.1038/nm0404-339
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news and views Cancer's sphere of influence
Charlotte Schubert Nature Medicine10, 349
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review article Microtubules as a target for anticancer drugs
Mary Ann Jordan and Leslie Wilson Nature Reviews Cancer4, 253–265
(April 2004); doi:10.1038/nrc1317
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letter Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer
Hiromu Suzuki, D Neil Watkins, Kam-Wing Jair, Kornel E Schuebel, Sanford D Markowitz, Wei Dong Chen, Theresa P Pretlow, Bin Yang, Yoshimitsu Akiyama, Manon van Engeland, Minoru Toyota, Takashi Tokino, Yuji Hinoda, Kohzoh Imai, James G Herman and Stephen B Baylin Nature Genetics36, 417–422
(April 2004); doi:10.1038/ng1330
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letter ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating
Martin Bienengraeber, Timothy M Olson, Vitaliy A Selivanov, Eva C Kathmann, Fearghas O'Cochlain, Fan Gao, Amy B Karger, Jeffrey D Ballew, Denice M Hodgson, Leonid V Zingman, Yuan-Ping Pang, Alexey E Alekseev and Andre Terzic Nature Genetics36, 382–387
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review article Chemogenomics: an emerging strategy for rapid target and drug discovery
Markus Bredel and Edgar Jacoby Nature Reviews Genetics5, 262–275
(April 2004)
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article Stability of dendritic spines and synaptic contacts is controlled by αN-catenin
Kentaro Abe, Osamu Chisaka, Frans van Roy and Masatoshi Takeichi Nature Neuroscience7, 357–363
(April 2004); doi:10.1038/nn1212
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news and views Stiffening the spines
Annette Markus Nature Neuroscience7, 322
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research article Expression profiling using a hexamer-based universal microarray
Matthew E Roth, Li Feng, Kevin J McConnell, Paul J Schaffer, Cesar E Guerra, Jason P Affourtit, Kevin R Piper, Lorri Guccione, Jayashree Hariharan, Maura J Ford, Stephen W Powell, Harish Krishnaswamy, Jennifer Lane, Lisa Guccione, Gino Intrieri, Jane S Merkel, Clotilde Perbost, Anthony Valerio, Brenda Zolla, Carol D Graham, Jonathan Hnath, Chris Michaelson, Rixin Wang, Baoge Ying, Conrad Halling, Craig E Parman, Debasish Raha, Brent Orr, Barbara Jedrzkiewicz, Ji Liao, Anton Tevelev, Martin J Mattessich, David M Kranz, Michelle Lacey, Joseph C Kaufman, Junhyong Kim, Darin R Latimer and Paul M Lizardi Nature Biotechnology22, 418–426
(April 2004); doi:10.1038/nbt948
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review article AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome
Neil Ruderman and Marc Prentki Nature Reviews Drug Discovery3, 340–351
(April 2004); doi:10.1038/nrd1344
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article p27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding
Eilyn R Lacy, Igor Filippov, William S Lewis, Steve Otieno, Limin Xiao, Sonja Weiss, Ludger Hengst and Richard W Kriwacki Nature Structural and Molecular Biology11, 358–364
(April 2004); doi:10.1038/nsmb746
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