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The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.
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letters to nature
VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model
Mimoun Azzouz, G. Scott Ralph, Erik Storkebaum, Lucy E. Walmsley, Kyriacos A. Mitrophanous, Susan M. Kingsman, Peter Carmeliet and Nicholas D. Mazarakis
Nature 429, 413–417
(27 May 2004); doi:10.1038/nature02544
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letters to nature
Premature ageing in mice expressing defective mitochondrial DNA polymerase
Aleksandra Trifunovic, Anna Wredenberg, Maria Falkenberg, Johannes N. Spelbrink, Anja T. Rovio, Carl E. Bruder, Mohammad Bohlooly-Y, Sebastian Gidlöf, Anders Oldfors, Rolf Wibom, Jan Törnell, Howard T. Jacobs and Nils-Göran Larsson
Nature 429, 417–423
(27 May 2004); doi:10.1038/nature02517
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news and views
Ageing: Mice and mitochondria
George M. Martin and Lawrence A. Loeb
Nature 429, 357–359
(27 May 2004); doi:10.1038/429357a
| Full Text (HTML / PDF) |
letters to nature
An autonomous molecular computer for logical control of gene expression
Yaakov Benenson, Binyamin Gil, Uri Ben-Dor, Rivka Adar and Ehud Shapiro
Nature 429, 423–429
(27 May 2004); doi:10.1038/nature02551
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news and views
Automata make antisense
Anne Condon
Nature 429, 351–352
(27 May 2004); doi:10.1038/429351a
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letters to nature
Human meiotic recombinase Dmc1 promotes ATP-dependent homologous DNA strand exchange
Michael G. Sehorn, Stefan Sigurdsson, Wendy Bussen, Vinzenz M. Unger and Patrick Sung
Nature 429, 433–437
(27 May 2004); doi:10.1038/nature02563
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article
FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P
Anna Godi, Antonella Di Campli, Athanasios Konstantakopoulos, Giuseppe Di Tullio, Dario R. Alessi, Gursant S. Kular, Tiziana Daniele, Pierfrancesco Marra, John M. Lucocq and M. Antonietta De Matteis
Nature Cell Biology 6, 393–404
(May 2004); doi:10.1038/ncb1119
| Abstract | Full Text (HTML/PDF) |
news and views
New candidates for vesicle coat proteins
Michael Roth
Nature Cell Biology 6, 384–385
(May 2004); doi:10.1038/ncb0504-384
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letter
PtdIns(3,4,5)P3 binding is necessary for WAVE2-induced formation of lamellipodia
Tsukasa Oikawa, Hideki Yamaguchi, Toshiki Itoh, Masayoshi Kato, Takeshi Ijuin, Daisuke Yamazaki, Shiro Suetsugu and Tadaomi Takenawa
Nature Cell Biology 6, 420–426
(May 2004); doi:10.1038/ncb1125
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news and views
A Bit-role for integrins in apoptosis
Dwayne G. Stupack and David A. Cheresh
Nature Cell Biology 6, 388–389
(May 2004); doi:10.1038/ncb0504-388
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review article
Oxygen sensing by HIF hydroxylases
Christopher J. Schofield and Peter J. Ratcliffe
Nature Reviews Molecular Cell Biology 5, 343–354
(May 2004); doi:10.1038/nrm1366
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review article
A means to a DNA end: the many roles of Ku
Jessica A. Downs and Stephen P. Jackson
Nature Reviews Molecular Cell Biology 5, 367–378
(May 2004); doi:10.1038/nrm1367
| Abstract | Full Text (HTML / PDF) |
perspectives
Opinion: Actin up in the nucleus
Blaine T. Bettinger, David M. Gilbert and David C. Amberg
Nature Reviews Molecular Cell Biology 5, 410–415
(May 2004); doi:10.1038/nrm1370
| Abstract | Full Text (HTML / PDF) |
article
53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination
John P Manis, Julio C Morales, Zhenfang Xia, Jeffery L Kutok, Frederick W Alt and Phillip B Carpenter
Nature Immunology 5, 481–487
(May 2004); doi:10.1038/ni1067
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news and views
Paradigm switching in the germinal center
Jennifer E Posey, Vicky L Brandt and David B Roth
Nature Immunology 5, 476–477
(May 2004); doi:10.1038/ni0504-476
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article
Analysis of regulatory CD8 T cells in Qa-1-deficient mice
Dan Hu, Koichi Ikizawa, Linrong Lu, Marie E Sanchirico, Mari L Shinohara and Harvey Cantor
Nature Immunology 5, 516–523
(May 2004); doi:10.1038/ni1063
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news and views
Resurrecting CD8+ suppressor T cells
Leonard Chess and Hong Jiang
Nature Immunology 5, 469–471
(May 2004); doi:10.1038/ni0504-469
| Full Text (HTML/PDF) |
article
The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development
Heather J Hinton, Dario R Alessi and Doreen A Cantrell
Nature Immunology 5, 539–545
(May 2004); doi:10.1038/ni1062
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review article
CARMA1, BCL-10 and MALT1 in lymphocyte development and activation
Margot Thome
Nature Reviews Immunology 4, 348–359
(May 2004); doi:10.1038/nri1352
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review article
Lymphocyte trafficking across high endothelial venules: dogmas and enigmas
Masayuki Miyasaka and Toshiyuki Tanaka
Nature Reviews Immunology 4, 360–370
(May 2004); doi:10.1038/nri1354
| Abstract | Full Text (HTML / PDF) |
brief communication
The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis
Davide Ruggero, Lorenzo Montanaro, Li Ma, Wei Xu, Paola Londei, Carlos Cordon-Cardo and Pier Paolo Pandolfi
Nature Medicine 10, 484–486
(May 2004); doi:10.1038/nm1042
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article
Regulation of angiogenesis by tissue factor cytoplasmic domain signaling
Mattias Belting, Michael I Dorrell, Staffan Sandgren, Edith Aguilar, Jasimuddin Ahamed, Andrea Dorfleutner, Peter Carmeliet, Barbara M Mueller, Martin Friedlander and Wolfram Ruf
Nature Medicine 10, 502–509
(May 2004); doi:10.1038/nm1037
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article
Adiponectin acts in the brain to decrease body weight
Yong Qi, Nobuhiko Takahashi, Stanley M Hileman, Hiralben R Patel, Anders H Berg, Utpal B Pajvani, Philipp E Scherer and Rexford S Ahima
Nature Medicine 10, 524–529
(May 2004); doi:10.1038/nm1029
| Abstract | Full Text (HTML/PDF) |
news and views
Fat hormones pull their weight in the CNS
Randy J Seeley, David A D'Alessio and Stephen C Woods
Nature Medicine 10, 454–455
(May 2004); doi:10.1038/nm0504-454
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letter
PGC-1 promotes insulin resistance in liver through PPAR-α-dependent induction of TRB-3
Seung-Hoi Koo, Hiroaki Satoh, Stephan Herzig, Chih-Hao Lee, Susan Hedrick, Rohit Kulkarni, Ronald M Evans, Jerrold Olefsky and Marc Montminy
Nature Medicine 10, 530–534
(May 2004); doi:10.1038/nm1044
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review article
Molecules and mechanisms of the graft-versus-leukaemia effect
Marie Bleakley and Stanley R. Riddell
Nature Reviews Cancer 4, 371–380
(May 2004); doi:10.1038/nrc1365
| Abstract | Full Text (HTML / PDF) |
review article
C/EBPα mutations in acute myeloid leukaemias
Claus Nerlov
Nature Reviews Cancer 4, 394–400
(May 2004); doi:10.1038/nrc1363
| Abstract | Full Text (HTML / PDF) |
article
Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia
Yiguo Hu, Yuhua Liu, Shawn Pelletier, Elisabeth Buchdunger, Markus Warmuth, Doriano Fabbro, Michael Hallek, Richard A Van Etten and Shaoguang Li
Nature Genetics 36, 453–461
(May 2004); doi:10.1038/ng1343
| Abstract | Full Text (HTML/PDF) |
news and views
Src kinases in Ph+ lymphoblastic leukemia
Michael Deininger
Nature Genetics 36, 440–441
(May 2004); doi:10.1038/ng0504-440
| Full Text (HTML/PDF) |
letter
Oligo-astheno-teratozoospermia in mice lacking Cnot7, a regulator of retinoid X receptor beta
Takahisa Nakamura, Ryoji Yao, Takehiko Ogawa, Toru Suzuki, Chizuru Ito, Naoki Tsunekawa, Kimiko Inoue, Rieko Ajima, Takashi Miyasaka, Yutaka Yoshida, Atsuo Ogura, Kiyotaka Toshimori, Toshiaki Noce, Tadashi Yamamoto and Tetsuo Noda
Nature Genetics 36, 528–533
(May 2004); doi:10.1038/ng1344
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article
Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling
Juha-Pekka Himanen, Michael J Chumley, Martin Lackmann, Chen Li, William A Barton, Phillip D Jeffrey, Christopher Vearing, Detlef Geleick, David A Feldheim, Andrew W Boyd, Mark Henkemeyer and Dimitar B Nikolov
Nature Neuroscience 7, 501–509
(May 2004); doi:10.1038/nn1237
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news and views
Eph-ephrin promiscuity is now crystal clear
Elena B Pasquale
Nature Neuroscience 7, 417–418
(May 2004); doi:10.1038/nn0504-417
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review article
Cellular and molecular mechanisms of presynaptic assembly
Noam E. Ziv and Craig C. Garner
Nature Reviews Neuroscience 5, 385–399
(May 2004); doi:10.1038/nrn1370
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review article
Genetic mechanisms that underlie epilepsy
Ortrud K. Steinlein
Nature Reviews Neuroscience 5, 400–408
(May 2004); doi:10.1038/nrn1388
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article
Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim
Nieng Yan, Jia-Wei Wu, Jijie Chai, Wenyu Li and Yigong Shi
Nature Structural and Molecular Biology 11, 420–428
(May 2004); doi:10.1038/nsmb764
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news and views
A fine balance for life and death decisions
Barbara A Schreader and John R Nambu
Nature Structural and Molecular Biology 11, 386–388
(May 2004); doi:10.1038/nsmb0504-386
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letters to nature
Zinc transporter LIVI controls epithelial-mesenchymal transition in zebrafish gastrula organizer
Susumu Yamashita , Chiemi Miyagi, Toshiyuki Fukada, Naofumi Kagara, Yong-Suk Che and Toshio Hirano
Nature 429, 298–302
(20 May 2004); doi:10.1038/nature02545
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letters to nature
Identification of the pollen determinant of S-RNase-mediated self-incompatibility
Paja Sijacic, Xi Wang, Andrea L. Skirpan, Yan Wang, Peter E. Dowd, Andrew G. McCubbin, Shihshieh Huang and Teh-hui Kao
Nature 429, 302–305
(20 May 2004); doi:10.1038/nature02523
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letters to nature
Self-incompatibility triggers programmed cell death in Papaver pollen
Steven G. Thomas and Vernonica E. Franklin-Tong
Nature 429, 305–309
(20 May 2004); doi:10.1038/nature02540
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news and views
Reproductive biology: Pillow talk in plants
Bruce McClure
Nature 429, 249–250
(20 May 2004); doi:10.1038/429249a
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letters to nature
Rab5 is a signalling GTPase involved in actin remodelling by receptor tyrosine kinases
Letizia Lanzetti, Andrea Palamidessi, Liliana Areces, Giorgio Scita and Pier Paolo Di Fiore
Nature 429, 309–314
(20 May 2004); doi:10.1038/nature02542
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letters to nature
Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain
Jin-Biao Ma, Keqiong Ye and Dinshaw J. Patel
Nature 429, 318–322
(20 May 2004); doi:10.1038/nature02519
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news and views
Malaria: The calcium connection
Amanda Tromans
Nature 429, 253
(20 May 2004); doi:10.1038/429253a
| Full Text (HTML / PDF) |
letter
Egalitarian binds dynein light chain to establish oocyte polarity and maintain oocyte fate
Caryn Navarro, Hamsa Puthalakath, Jerry M. Adams, Andreas Strasser and Ruth Lehmann
Nature Cell Biology 6, 427–435
(May 2004); doi:10.1038/ncb1122
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news and views
Egalitarian and the case of the missing link
John Pearson and Acaimo González-Reyes
Nature Cell Biology 6, 381–383
(May 2004); doi:10.1038/ncb0504-381
| Full Text (HTML/PDF) |
letter
Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex
J. I-Ju Leu, Patrick Dumont, Michael Hafey, Maureen E. Murphy and Donna L. George
Nature Cell Biology 6, 443–450
(May 2004); doi:10.1038/ncb1123
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news and views
Fatal liaisons of p53 with Bax and Bak
Jean-Luc Perfettini, Romano T. Kroemer and Guido Kroemer
Nature Cell Biology 6, 386–388
(May 2004); doi:10.1038/ncb0504-386
| Full Text (HTML/PDF) |
review article
RAS and RHO GTPases in G1-phase cell-cycle regulation
Mathew L. Coleman, Christopher J. Marshall and Michael F. Olson
Nature Reviews Molecular Cell Biology 5, 355–366
(May 2004); doi:10.1038/nrm1365
| Abstract | Full Text (HTML / PDF) |
perspectives
Opinion: Regulatory diversity among metazoan co-activator complexes
Dylan J. Taatjes, Michael T. Marr and Robert Tjian
Nature Reviews Molecular Cell Biology 5, 403–410
(May 2004); doi:10.1038/nrm1369
| Abstract | Full Text (HTML / PDF) |
article
RIP1 is an essential mediator of Toll-like receptor 3-induced NF-κB activation
Etienne Meylan, Kim Burns, Kay Hofmann, Vincent Blancheteau, Fabio Martinon, Michelle Kelliher and Jürg Tschopp
Nature Immunology 5, 503–507
(May 2004); doi:10.1038/ni1061
| Abstract | Full Text (HTML/PDF) |
news and views
Toll signaling: RIPping off the TNF pathway
Gregory M Barton and Ruslan Medzhitov
Nature Immunology 5, 472–474
(May 2004); doi:10.1038/ni0504-472
| Full Text (HTML/PDF) |
article
Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance
Yiping Yang, Ching-Tai Huang, Xiaopei Huang and Drew M Pardoll
Nature Immunology 5, 508–515
(May 2004); doi:10.1038/ni1059
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article
T cell killing does not require the formation of a stable mature immunological synapse
Marco A Purbhoo, Darrell J Irvine, Johannes B Huppa and Mark M Davis
Nature Immunology 5, 524–530
(May 2004); doi:10.1038/ni1058
| Abstract | Full Text (HTML/PDF) |
article
A single class II myosin modulates T cell motility and stopping, but not synapse formation
Jordan Jacobelli, Stephen A Chmura, Denis B Buxton, Mark M Davis and Matthew F Krummel
Nature Immunology 5, 531–538
(May 2004); doi:10.1038/ni1065
| Abstract | Full Text (HTML/PDF) |
review article
Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity
Lieping Chen
Nature Reviews Immunology 4, 336–347
(May 2004); doi:10.1038/nri1349
| Abstract | Full Text (HTML / PDF) |
article
Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease
Miriam Merad, Petra Hoffmann, Erik Ranheim, Sarah Slaymaker, Markus G Manz, Sergio A Lira, Israel Charo, Donald N Cook, Irving L Weissman, Samuel Strober and Edgar G Engleman
Nature Medicine 10, 510–517
(May 2004); doi:10.1038/nm1038
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news and views
Tanning before transplant: lancing the Langerhans cell
Stephen G Emerson
Nature Medicine 10, 451–452
(May 2004); doi:10.1038/nm0504-451
| Full Text (HTML/PDF) |
article
Mutation of the COG complex subunit gene COG7 causes a lethal congenital disorder
Xiaohua Wu, Richard A Steet, Ognian Bohorov, Jaap Bakker, John Newell, Monty Krieger, Leo Spaapen, Stuart Kornfeld and Hudson H Freeze
Nature Medicine 10, 518–523
(May 2004); doi:10.1038/nm1041
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news and views
A COG in the sugar machine
Thorsten Marquardt
Nature Medicine 10, 457–458
(May 2004); doi:10.1038/nm0504-457
| Full Text (HTML/PDF) |
letter
Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responses
Ram Kumar Mathur, Amit Awasthi, Pallavi Wadhone, B Ramanamurthy and Bhaskar Saha
Nature Medicine 10, 540–544
(May 2004); doi:10.1038/nm1045
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review article
Searching for the hereditary causes of renal-cell carcinoma
Christian P. Pavlovich and Laura S. Schmidt
Nature Reviews Cancer 4, 381–393
(May 2004); doi:10.1038/nrc1364
| Abstract | Full Text (HTML / PDF) |
perspectives
Timeline: The discovery of receptor tyrosine kinases: targets for cancer therapy
Andreas Gschwind, Oliver M. Fischer and Axel Ullrich
Nature Reviews Cancer 4, 361–370
(May 2004); doi:10.1038/nrc1360
| Abstract | Full Text (HTML / PDF) |
letter
Functional variants of OCTN cation transporter genes are associated with Crohn disease
Vanya D Peltekova, Richard F Wintle, Laurence A Rubin, Christopher I Amos, Qiqing Huang, Xiangjun Gu, Bill Newman, Mark Van Oene, David Cescon, Gordon Greenberg, Anne M Griffiths, Peter H St George-Hyslop and Katherine A Siminovitch
Nature Genetics 36, 471–475
(May 2004); doi:10.1038/ng1339
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letter
Gene regulatory network growth by duplication
Sarah A Teichmann and M Madan Babu
Nature Genetics 36, 492–496
(May 2004); doi:10.1038/ng1340
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letter
SUMO modification is required for in vivo Hox gene regulation by the Caenorhabditis elegans Polycomb group protein SOP-2
Hong Zhang, Gromoslaw A Smolen, Rachel Palmer, Andrea Christoforou, Sander van den Heuvel and Daniel A Haber
Nature Genetics 36, 507–511
(May 2004); doi:10.1038/ng1336
| First Paragraph | Full Text (HTML/PDF) |
brief communication
Circadian regulation of GABAA receptor function by CKIε-CKIδ in the rat suprachiasmatic nuclei
Ke Ning, Lei Li, Mingxia Liao, Baosong Liu, John G Mielke, Yonghong Chen, Ying Duan, Youssef H El-Hayek and Qi Wan
Nature Neuroscience 7, 489–490
(May 2004); doi:10.1038/nn1236
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brief communication
Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus
Marco van den Top, Kevin Lee, Andrew D Whyment, Andrew M Blanks and David Spanswick
Nature Neuroscience 7, 493–494
(May 2004); doi:10.1038/nn1226
| First Paragraph | Full Text (HTML/PDF) |
perspectives
Proteomics in postgenomic neuroscience: the end of the beginning
Jyoti Choudhary and Seth G N Grant
Nature Neuroscience 7, 440–445
(May 2004); doi:10.1038/nn1240
| Abstract | Full Text (HTML/PDF) |
review article
Glial specification in the vertebrate neural tube
David H. Rowitch
Nature Reviews Neuroscience 5, 409–419
(May 2004); doi:10.1038/nrn1389
| Abstract | Full Text (HTML / PDF) |
compbio
Microarray reality checks in the context of a complex disease
George L Gabor Miklos and Ryszard Maleszka
Nature Biotechnology 22, 615–621
(May 2004); doi:10.1038/nbt965
| Abstract | Full Text (HTML/PDF) |
letters to nature
Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors
Weihai He, Frederick J.-P. Miao, Daniel C.-H. Lin, Ralf T. Schwandner, Zhulun Wang, Jinhai Gao, Jin-Long Chen, Hui Tian and Lei Ling
Nature 429, 188–193
(13 May 2004); doi:10.1038/nature02488
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news and views
Physiology: Orphan detectors of metabolism
Steven C. Hebert
Nature 429, 143–145
(13 May 2004); doi:10.1038/429143a
| Full Text (HTML / PDF) |
letters to nature
Aquaporin-0 membrane junctions reveal the structure of a closed water pore
Tamir Gonen, Piotr Sliz, Joerg Kistler, Yifan Cheng and Thomas Walz
Nature 429, 193–197
(13 May 2004); doi:10.1038/nature02503
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letters to nature
The GTPase-activating protein Rap1GAP uses a catalytic asparagine
Oliver Daumke, Michael Weyand, Partha P. Chakrabarti, Ingrid R. Vetter and Alfred Wittinghofer
Nature 429, 197–201
(13 May 2004); doi:10.1038/nature02505
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news and views
Signal transduction: Thumbs up for inactivation
Holger Rehmann and Johannes L. Bos
Nature 429, 138–139
(13 May 2004); doi:10.1038/429138a
| Full Text (HTML / PDF) |
news and views
Membrane trafficking: Dual-key strategy
Toshiki Itoh and Pietro De Camilli
Nature 429, 141–143
(13 May 2004); doi:10.1038/429141a
| Full Text (HTML / PDF) |
news and views
Muscle: The sliding filament at 50
Maxine Clarke
Nature 429, 145
(13 May 2004); doi:10.1038/429145a
| Full Text (HTML / PDF) |
news and views feature
Ageing and the mystery at Arles
Shino Nemoto and Toren Finkel
Nature 429, 149–152
(13 May 2004); doi:10.1038/429149a
| Full Text (HTML / PDF) |
article
Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p
Rudy Behnia, Bojana Panic, James R. C. Whyte and Sean Munro
Nature Cell Biology 6, 405–413
(May 2004); doi:10.1038/ncb1120
| Abstract | Full Text (HTML/PDF) |
article
Golgi targeting of ARF-like GTPase Arl3p requires its Nα-acetylation and the integral membrane protein Sys1p
Subba Rao Gangi Setty, Todd I. Strochlic, Amy Hin Yan Tong, Charles Boone and Christopher G. Burd
Nature Cell Biology 6, 414–419
(May 2004); doi:10.1038/ncb1121
| Abstract | Full Text (HTML/PDF) |
news and views
N-terminal acetylation targets GTPases to membranes
Catherine L. Jackson
Nature Cell Biology 6, 379–380
(May 2004); doi:10.1038/ncb0504-379
| Full Text (HTML/PDF) |
review article
Shaping the nuclear action of NF-kB
Lin-Feng Chen and Warner C. Greene
Nature Reviews Molecular Cell Biology 5, 392–401
(May 2004); doi:10.1038/nrm1368
| Abstract | Full Text (HTML / PDF) |
perspectives
Opinion: Actin up in the nucleus
Blaine T. Bettinger, David M. Gilbert and David C. Amberg
Nature Reviews Molecular Cell Biology 5, 410–415
(May 2004); doi:10.1038/nrm1370
| Abstract | Full Text (HTML / PDF) |
article
TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM
Carole Couillault, Nathalie Pujol, Jérôme Reboul, Laurence Sabatier, Jean-François Guichou, Yuji Kohara and Jonathan J Ewbank
Nature Immunology 5, 488–494
(May 2004); doi:10.1038/ni1060
| Abstract | Full Text (HTML/PDF) |
news and views
Dissecting worm immunity
Jonathan Hodgkin
Nature Immunology 5, 471–472
(May 2004); doi:10.1038/ni0504-471
| Full Text (HTML/PDF) |
review article
Selectins in T-cell recruitment to non-lymphoid tissues and sites of inflammation
Klaus Ley and Geoffrey S. Kansas
Nature Reviews Immunology 4, 325–336
(May 2004); doi:10.1038/nri1351
| Abstract | Full Text (HTML / PDF) |
article
Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice
Marcus Mall, Barbara R Grubb, Jack R Harkema, Wanda K O'Neal and Richard C Boucher
Nature Medicine 10, 487–493
(May 2004); doi:10.1038/nm1028
| Abstract | Full Text (HTML/PDF) |
news and views
Finally, mice with CF lung disease
Raymond A Frizzell and Joseph M Pilewski
Nature Medicine 10, 452–454
(May 2004); doi:10.1038/nm0504-452
| Full Text (HTML/PDF) |
news and views
Arming the osteoclast
Roland Baron
Nature Medicine 10, 458–460
(May 2004); doi:10.1038/nm0504-458
| Full Text (HTML/PDF) |
review article
The TOR pathway: a target for cancer therapy
Mary-Ann Bjornsti and Peter J. Houghton
Nature Reviews Cancer 4, 335–348
(May 2004); doi:10.1038/nrc1362
| Abstract | Full Text (HTML / PDF) |
article
The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression
Jun Chul Kim, Jose L Badano, Sonja Sibold, Muneer A Esmail, Josephine Hill, Bethan E Hoskins, Carmen C Leitch, Kerrie Venner, Stephen J Ansley, Alison J Ross, Michel R Leroux, Nicholas Katsanis and Philip L Beales
Nature Genetics 36, 462–470
(May 2004); doi:10.1038/ng1352
| Abstract | Full Text (HTML/PDF) |
review article
Time to draw breath: asthma-susceptibility genes are identified
Marsha Wills-Karp and Susan L. Ewart
Nature Reviews Genetics 5, 376–387
(May 2004); doi:10.1038/nrg1326
| Abstract | Full Text (HTML / PDF) |
article
Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates
Leping Cheng, Akiko Arata, Rumiko Mizuguchi, Ying Qian, Asanka Karunaratne, Paul A Gray, Satoru Arata, Senji Shirasawa, Maxime Bouchard, Ping Luo, Chih-Li Chen, Meinrad Busslinger, Martyn Goulding, Hiroshi Onimaru and Qiufu Ma
Nature Neuroscience 7, 510–517
(May 2004); doi:10.1038/nn1221
| Abstract | Full Text (HTML/PDF) |
news and views
Tlx genes make an exciting choice
Stewart Anderson
Nature Neuroscience 7, 421–422
(May 2004); doi:10.1038/nn0504-421
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review article
Experimental therapeutics in transgenic mouse models of Huntington's disease
M. Flint Beal and Robert J. Ferrante
Nature Reviews Neuroscience 5, 373–384
(May 2004); doi:10.1038/nrn1386
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news and views
Encoded self-assembly chemical libraries
Samu Melkko, Jörg Scheuermann, Christoph E Dumelin & Dario Neri
Nature Biotechnology 7, 568–574
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Communication between ClpX and ClpP during substrate processing and degradation
Shilpa A Joshi, Greg L Hersch, Tania A Baker and Robert T Sauer
Nature Structural and Molecular Biology 11, 404–411
(May 2004); doi:10.1038/nsmb752
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review article
Type IV pilus structure and bacterial pathogenicity
Lisa Craig, Michael E. Pique and John A. Tainer
Nature Reviews Microbiology 2, 363–378
(May 2004); doi:10.1038/nrmicro885
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Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
Yuval Dor, Juliana Brown, Olga I. Martinez and Douglas A. Melton
Nature 429, 41–46
(06 May 2004); doi:10.1038/nature02520
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Regenerative medicine: Self-help for insulin cells
Ken Zaret
Nature 429, 30–31
(06 May 2004); doi:10.1038/429030a
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letters to nature
Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-α secretion in vitro
Kouichi Ozaki, Katsumi Inoue, Hiroshi Sato, Aritoshi Iida, Yozo Ohnishi, Akihiro Sekine, Hideyuki Sato, Keita Odashiro, Masakiyo Nobuyoshi, Masatsugu Hori, Yusuke Nakamura and Toshihiro Tanaka
Nature 429, 72–75
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letters to nature
Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms
Maya Saleh, John P. Vaillancourt, Rona K. Graham, Matthew Huyck, Srinivasa M. Srinivasula, Emad S. Alnemri, Martin H. Steinberg, Vikki Nolan, Clinton T. Baldwin, Richard S. Hotchkiss, Timothy G. Buchman, Barbara A. Zehnbauer, Michael R. Hayden, Lindsay A. Farrer, Sophie Roy and Donald W. Nicholson
Nature 429, 75–79
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Human genetics: An inflammatory issue
Kevin J. Tracey and H. Shaw Warren
Nature 429, 35–37
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letters to nature
Nitration of a peptide phytotoxin by bacterial nitric oxide synthase
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Nature 429, 79–82
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letters to nature
Mechanotransduction through growth-factor shedding into the extracellular space
Daniel J. Tschumperlin, Guohao Dai, Ivan V. Maly, Tadashi Kikuchi, Lily H. Laiho, Anna K. McVittie, Kathleen J. Haley, Craig M. Lilly, Peter T. C. So, Douglas A. Lauffenburger, Roger D. Kamm and Jeffrey M. Drazen
Nature 429, 83–86
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letters to nature
The ubiquitin ligase COP1 is a critical negative regulator of p53
David Dornan, Ingrid Wertz, Harumi Shimizu, David Arnott, Gretchen D. Frantz, Patrick Dowd, Karen O' Rourke, Hartmut Koeppen and Vishva M. Dixit
Nature 429, 86–92
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letters to nature
Integrating high-throughput and computational data elucidates bacterial networks
Markus W. Covert, Eric M. Knight, Jennifer L. Reed, Markus J. Herrgard and Bernhard O. Palsson
Nature 429, 92–96
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In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the early G1-phase inhibitor, p18INK4C
Youzhong Yuan, Hongmei Shen, David S. Franklin, David T. Scadden and Tao Cheng
Nature Cell Biology 6, 436–442
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An epididymis-specific β-defensin is important for the initiation of sperm maturation
Chen Xi Zhou, Yong-Lian Zhang, Liqing Xiao, Min Zheng, Ka Man Leung, Man Yee Chan, Pui Shan Lo, Lai Ling Tsang, Hau Yan Wong, Lok Sze Ho, Yiu Wa Chung and Hsiao Chang Chan
Nature Cell Biology 6, 458–464
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Actin dynamics: re-drawing the map
Phillip R. Gordon-Weeks
Nature Cell Biology 6, 390–391
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review article
Plant cell biology: Signals that control plant vascular cell differentiation
Hiroo Fukuda
Nature Reviews Molecular Cell Biology 5, 379–391
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Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors
Tsung-Hsien Chuang and Richard J Ulevitch
Nature Immunology 5, 495–502
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Nature's fortress against infection
Steven A Wasserman
Nature Immunology 5, 474–475
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The weight of leptin in immunity
Antonio La Cava and Giuseppe Matarese
Nature Reviews Immunology 4, 371–379
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Innovation: Novel ChIP-based strategies to uncover transcription factor target genes in the immune system
Amy S. Weinmann
Nature Reviews Immunology 4, 381–386
(May 2004); doi:10.1038/nri1353
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brief communication
Peroxisome proliferator-activated receptor-δ attenuates colon carcinogenesis
Fred S Harman, Christopher J Nicol, Holly E Marin, Jerrold M Ward, Frank J Gonzalez and Jeffrey M Peters
Nature Medicine 10, 481–483
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The proteasome: a suitable antineoplastic target
Julian Adams
Nature Reviews Cancer 4, 349–360
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Genetic variation in DLG5 is associated with inflammatory bowel disease
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Nature Genetics 36, 476–480
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Just-in-time transcription program in metabolic pathways
Alon Zaslaver, Avi E Mayo, Revital Rosenberg, Pnina Bashkin, Hila Sberro, Miri Tsalyuk, Michael G Surette and Uri Alon
Nature Genetics 36, 486–491
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Improving the efficiency of RNA interference in mammals
Vivek Mittal
Nature Reviews Genetics 5, 355–365
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Retrograde activation of presynaptic NMDA receptors enhances GABA release at cerebellar interneuron-Purkinje cell synapses
Ian C Duguid and Trevor G Smart
Nature Neuroscience 7, 525–533
(May 2004); doi:10.1038/nn1227
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Presynaptic NMDA receptors get into the act
Anastassios V Tzingounis and Roger A Nicoll
Nature Neuroscience 7, 419–420
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NMDA receptors, place cells and hippocampal spatial memory
Kazu Nakazawa , Thomas J. McHugh , Matthew A. Wilson and Susumu Tonegawa
Nature Reviews Neuroscience 5, 361–372
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research article
High-affinity binders selected from designed ankyrin repeat protein libraries
H Kaspar Binz, Patrick Amstutz, Andreas Kohl, Michael T Stumpp, Christophe Briand, Patrik Forrer, Markus G Grütter and Andreas Plückthun
Nature Biotechnology 22, 575–582
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Next-generation protein drugs
Ian M Tomlinson
Nature Biotechnology 22, 521–522
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Molecular recognition of BMP-2 and BMP receptor IA
Sascha Keller, Joachim Nickel, Jin-Li Zhang, Walter Sebald and Thomas D Mueller
Nature Structural and Molecular Biology 11, 481–488
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