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The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.
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article
A membrane protein required for dislocation of misfolded proteins from the ER
Brendan N. Lilley and Hidde L. Ploegh
Nature 429, 834–840
(24 June 2004); doi:10.1038/nature02592
| Abstract | Full Text (HTML / PDF) |
article
A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol
Yihong Ye, Yoko Shibata, Chi Yun, David Ron and Tom A. Rapoport
Nature 429, 841–847
(24 June 2004); doi:10.1038/nature02656
| Abstract | Full Text (HTML / PDF) |
news and views
Cell biology: A channel for protein waste
Randy Schekman
Nature 429, 817–818
(24 June 2004); doi:10.1038/429817a
| Full Text (HTML / PDF) |
letters to nature
A proteoglycan mediates inductive interaction during plant vascular development
Hiroyasu Motose, Munetaka Sugiyama and Hiroo Fukuda
Nature 429, 873–878
(24 June 2004); doi:10.1038/nature02613
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Rapid BDNF-induced retrograde synaptic modification in a developing retinotectal system
Jiu-lin Du and Mu-ming Poo
Nature 429, 878–883
(24 June 2004); doi:10.1038/nature02618
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Gene regulation and DNA damage in the ageing human brain
Tao Lu, Ying Pan, Shyan-Yuan Kao, Cheng Li, Isaac Kohane, Jennifer Chan and Bruce A. Yankner
Nature 429, 883–891
(24 June 2004); doi:10.1038/nature02661
| First Paragraph | Full Text (HTML / PDF) |
news and views
Heart disease: An ongoing genetic battle?
Deepak Srivastava
Nature 429, 819–822
(24 June 2004); doi:10.1038/429819a
| Full Text (HTML / PDF) |
letter
Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling
Sachiko Kamakura, Koji Oishi, Takeshi Yoshimatsu, Masato Nakafuku, Norihisa Masuyama and Yukiko Gotoh
Nature Cell Biology 6, 547–554
(June 2004); doi:10.1038/ncb1138
| First Paragraph | Full Text (HTML/PDF) |
news and views
Tip-ping off the COPs
Jon Reynolds
Nature Cell Biology 6, 478
(June 2004); doi:10.1038/ncb0604-478
| Full Text (HTML/PDF) |
review article
Juxtamembrane autoinhibition in receptor tyrosine kinases
Stevan R. Hubbard
Nature Reviews Molecular Cell Biology 5, 464–471
(June 2004); doi:10.1038/nrm1399
| Abstract | Full Text (HTML / PDF) |
article
A Bcl-2-dependent molecular timer regulates the lifespan and immunogenicity of dendritic cells
Wu-Shiun Hou and Luk Van Parijs
Nature Immunology 5, 583–589
(June 2004); doi:10.1038/ni1071
| Abstract | Full Text (HTML/PDF) |
news and views
Balancing life and death
Muriel Moser
Nature Immunology 5, 559–560
(June 2004); doi:10.1038/ni0604-559
| Full Text (HTML/PDF) |
article
Exacerbated graft-versus-host disease in Pirb−/− mice
Akira Nakamura, Eiji Kobayashi and Toshiyuki Takai
Nature Immunology 5, 623–629
(June 2004); doi:10.1038/ni1074
| Abstract | Full Text (HTML/PDF) |
review article
Elaborate interactions between the immune and nervous systems
Lawrence Steinman
Nature Immunology 5, 575–581
(June 2004); doi:10.1038/ni1078
| Abstract | Full Text (HTML/PDF) |
review article
Therapeutic potential of oral tolerance
Lloyd Mayer and Ling Shao
Nature Reviews Immunology 4, 407–419
(June 2004); doi:10.1038/nri1370
| Abstract | Full Text (HTML / PDF) |
article
Reversal of obesity by targeted ablation of adipose tissue
Mikhail G Kolonin, Pradip K Saha, Lawrence Chan, Renata Pasqualini and Wadih Arap
Nature Medicine 10, 625–632
(June 2004); doi:10.1038/nm1048
| Abstract | Full Text (HTML/PDF) |
news and views
Magic bullets melt fat
Marc L Reitman
Nature Medicine 10, 581–582
(June 2004); doi:10.1038/nm0604-581
| Full Text (HTML/PDF) |
letter
3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone
Thomas S Scanlan, Katherine L Suchland, Matthew E Hart, Grazia Chiellini, Yong Huang, Paul J Kruzich, Sabina Frascarelli, Dane A Crossley, II James R Bunzow, Simonetta Ronca-Testoni, Emil T Lin, Daniel Hatton, Riccardo Zucchi and David K Grandy
Nature Medicine 10, 638–642
(June 2004); doi:10.1038/nm1051
| First Paragraph | Full Text (HTML/PDF) |
news and views
The two-timing thyroid
Stephen B Liggett
Nature Medicine 10, 582–583
(June 2004); doi:10.1038/nm0604-582
| Full Text (HTML/PDF) |
news and views
Balancing muscle hypertrophy and atrophy
Eric P Hoffman and Gustavo A Nader
Nature Medicine 10, 584–585
(June 2004); doi:10.1038/nm0604-584
| Full Text (HTML/PDF) |
news and views
Tolerance tag team
Matthias von Herrath and Dirk Homann
Nature Medicine 10, 585–587
(June 2004); doi:10.1038/nm0604-585
| Full Text (HTML/PDF) |
review article
Exploiting tumour hypoxia in cancer treatment
J. Martin Brown and William R. Wilson
Nature Reviews Cancer 4, 437–447
(June 2004); doi:10.1038/nrc1367
| Abstract | Full Text (HTML / PDF) |
review article
Dissecting the metastatic cascade
Klaus Pantel and Ruud H. Brakenhoff
Nature Reviews Cancer 4, 448–456
(June 2004); doi:10.1038/nrc1370
| Abstract | Full Text (HTML / PDF) |
letter
Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1
Frank Rosenbauer, Katharina Wagner, Jeffery L Kutok, Hiromi Iwasaki, Michelle M Le Beau, Yutaka Okuno, Koichi Akashi, Steven Fiering and Daniel G Tenen
Nature Genetics 36, 624–630
(June 2004); doi:10.1038/ng1361
| First Paragraph | Full Text (HTML/PDF) |
news and views
Fine-tuning PU.1
Derek L Stirewalt
Nature Genetics 36, 550–551
(June 2004); doi:10.1038/ng0604-550
| Full Text (HTML/PDF) |
article
Ascl1/Mash1 is required for the development of central serotonergic neurons
Alexandre Pattyn, Nicolas Simplicio, J Hikke van Doorninck, Christo Goridis, François Guillemot and Jean-François Brunet
Nature Neuroscience 7, 589–595
(June 2004); doi:10.1038/nn1247
| Abstract | Full Text (HTML/PDF) |
article
Overexpression of type-1 adenylyl cyclase in mouse forebrain enhances recognition memory and LTP
Hongbing Wang, Gregory D Ferguson, Victor V Pineda, Paige E Cundiff and Daniel R Storm
Nature Neuroscience 7, 635–642
(June 2004); doi:10.1038/nn1248
| Abstract | Full Text (HTML/PDF) |
technical report
A new chemotaxis assay shows the extreme sensitivity of axons to molecular gradients
William J Rosoff, Jeffrey S Urbach, Mark A Esrick, Ryan G McAllister, Linda J Richards and Geoffrey J Goodhill
Nature Neuroscience 7, 678–682
(June 2004); doi:10.1038/nn1259
| Abstract | Full Text (HTML/PDF) |
news and views
Assaying axon sensitivity
Kalyani Narasimhan
Nature Neuroscience 7, 574
(June 2004); doi:10.1038/nn0604-574
| Full Text (HTML/PDF) |
review article
Serotonergic neurons as carbon dioxide sensors that maintain ph homeostasis
George B. Richerson
Nature Reviews Neuroscience 5, 449–461
(June 2004); doi:10.1038/nrn1409
| Abstract | Full Text (HTML / PDF) |
research article
Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues
Gerold Schmitt-Ulms, Kirk Hansen, Jialing Liu, Cynthia Cowdrey, Jian Yang, Stephen J DeArmond, Fred E Cohen, Stanley B Prusiner and Michael A Baldwin
Nature Biotechnology 22, 724–731
(June 2004); doi:10.1038/nbt969
| Abstract | Full Text (HTML/PDF) |
article
Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1
R Scott Williams, Megan S Lee, D Duong Hau and J N Mark Glover
Nature Structural and Molecular Biology 11, 519–525
(June 2004); doi:10.1038/nsmb776
| Abstract | Full Text (HTML/PDF) |
article
Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster
Jan Rehwinkel, Andrea Herold, Kerstin Gari, Thomas Köcher, Michaela Rode, Francesca L Ciccarelli, Matthias Wilm and Elisa Izaurralde
Nature Structural and Molecular Biology 11, 558–566
(June 2004); doi:10.1038/nsmb759
| Abstract | Full Text (HTML/PDF) |
article
Assembly of endocytic machinery around individual influenza viruses during viral entry
Michael J Rust, Melike Lakadamyali, Feng Zhang and Xiaowei Zhuang
Nature Structural and Molecular Biology 11, 567–573
(June 2004); doi:10.1038/nsmb769
| Abstract | Full Text (HTML/PDF) |
news and views
Opening the gate in potassium channels
Kenton J Swartz
Nature Structural and Molecular Biology 11, 499–501
(June 2004); doi:10.1038/nsmb0604-499
| Full Text (HTML/PDF) |
letters to nature
Enhanced partner preference in a promiscuous species by manipulating the expression of a single gene
Miranda M. Lim, Zuoxin Wang, Daniel E. Olazábal, Xianghui Ren, Ernest F. Terwilliger and Larry J. Young
Nature 429, 754–757
(17 June 2004); doi:10.1038/nature02539
| First Paragraph | Full Text (HTML / PDF) |
news and views
Neurobiology: Why voles stick together
Evan Balaban
Nature 429, 711–712
(17 June 2004); doi:10.1038/429711a
| Full Text (HTML / PDF) |
letters to nature
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
Frédéric Picard, Martin Kurtev, Namjin Chung, Acharawan Topark-Ngarm, Thanaset Senawong, Rita Machado de Oliveira, Mark Leid, Michael W. McBurney and Leonard Guarente
Nature 429, 771–776
(17 June 2004); doi:10.1038/nature02583
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Plant retinoblastoma homologues control nuclear proliferation in the female gametophyte
Chantal Ebel, Luisa Mariconti and Wilhelm Gruissem
Nature 429, 776–780
(17 June 2004); doi:10.1038/nature02637
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Structural basis of protein phosphatase 1 regulation
Mohammed Terrak, Frederic Kerff, Knut Langsetmo, Terence Tao and Roberto Dominguez
Nature 429, 780–784
(17 June 2004); doi:10.1038/nature02582
| First Paragraph | Full Text (HTML / PDF) |
letter
Memo mediates ErbB2-driven cell motility
Romina Marone, Daniel Hess, David Dankort, William J. Muller, Nancy E. Hynes and Ali Badache
Nature Cell Biology 6, 515–522
(June 2004); doi:10.1038/ncb1134
| First Paragraph | Full Text (HTML/PDF) |
news and views
Fusion has found its calcium sensor
Jacopo Meldolesi and Evelina Chieregatti
Nature Cell Biology 6, 476–478
(June 2004); doi:10.1038/ncb0604-476
| Full Text (HTML/PDF) |
review article
PI-loting membrane traffic
Maria Antonietta De Matteis and Anna Godi
Nature Cell Biology 6, 487–492
(June 2004); doi:10.1038/ncb0604-487
| Abstract | Full Text (HTML/PDF) |
perspectives
Opinion: γ-Secretase: proteasome of the membrane?
Raphael Kopan and Ma. Xenia G. Ilagan
Nature Reviews Molecular Cell Biology 5, 499–504
(June 2004); doi:10.1038/nrm1406
| Abstract | Full Text (HTML / PDF) |
article
Antigen-induced tolerance by intrathymic modulation of self-recognizing inhibitory receptors
Yoshihiro Hayakawa, Stuart P Berzins, Nadine Y Crowe, Dale I Godfrey and Mark J Smyth
Nature Immunology 5, 590–596
(June 2004); doi:10.1038/ni1069
| Abstract | Full Text (HTML/PDF) |
article
CD8+ T cells maintain tolerance to myelin basic protein by 'epitope theft'
Antoine Perchellet, Ingunn Stromnes, Jennifer M Pang and Joan Goverman
Nature Immunology 5, 606–614
(June 2004); doi:10.1038/ni1073
| Abstract | Full Text (HTML/PDF) |
article
Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo
Katsuto Hozumi, Naoko Negishi, Daisuke Suzuki, Natsumi Abe, Yusuke Sotomaru, Norikazu Tamaoki, Carolina Mailhos, David Ish-Horowicz, Sonoko Habu and Michael J Owen
Nature Immunology 5, 638–644
(June 2004); doi:10.1038/ni1075
| Abstract | Full Text (HTML/PDF) |
review article
Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40
Kazuo Sugamura, Naoto Ishii and Andrew D. Weinberg
Nature Reviews Immunology 4, 420–431
(June 2004); doi:10.1038/nri1371
| Abstract | Full Text (HTML / PDF) |
perspectives
Opinion: Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses
Seung-Yong Seong and Polly Matzinger
Nature Reviews Immunology 4, 469–478
(June 2004); doi:10.1038/nri1372
| Abstract | Full Text (HTML / PDF) |
article
Suramin inhibits death receptor-induced apoptosis in vitro and fulminant apoptotic liver damage in mice
Sören T Eichhorst, Andreas Krueger, Susanne Müerköster, Stefanie C Fas, Alexander Golks, Uwe Gruetzner, Louise Schubert, Christine Opelz, Manfred Bilzer, Alexander L Gerbes and Peter H Krammer
Nature Medicine 10, 602–609
(June 2004); doi:10.1038/nm1049
| Abstract | Full Text (HTML/PDF) |
news and views
Cheating death in the liver
M Eugenia Guicciardi and Gregory J Gores
Nature Medicine 10, 587–588
(June 2004); doi:10.1038/nm0604-587
| Full Text (HTML/PDF) |
letter
Insulin regulation of hepatic gluconeogenesis through phosphorylation of CREB-binding protein
Xiao Yan Zhou, Nobuyuki Shibusawa, Karuna Naik, Delia Porras, Karla Temple, Hesheng Ou, Kelly Kaihara, Michael W Roe, Matthew J Brady and Fredric E Wondisford
Nature Medicine 10, 633–637
(June 2004); doi:10.1038/nm1050
| First Paragraph | Full Text (HTML/PDF) |
technical report
Bioluminescent imaging of Cdk2 inhibition in vivo
Guo-Jun Zhang, Michal Safran, Wenyi Wei, Erik Sorensen, Peter Lassota, Nikolai Zhelev, Donna S Neuberg, Geoffrey Shapiro, and William G Kaelin Jr
Nature Medicine 10, 643–648
(June 2004); doi:10.1038/nm1047
| Abstract | Full Text (HTML/PDF) |
news and views
Targeting tumors: seeing the light
Charlotte Schubert
Nature Medicine 10, 580
(June 2004); doi:10.1038/nm0604-580
| Full Text (HTML/PDF) |
review article
The anti-angiogenic basis of metronomic chemotherapy
Robert S. Kerbel and Barton A. Kamen
Nature Reviews Cancer 4, 423–436
(June 2004); doi:10.1038/nrc1369
| Abstract | Full Text (HTML / PDF) |
letter
Cornelia de Lange syndrome is caused by mutations in NIPBL, the human homolog of Drosophila melanogaster Nipped-B
Ian D Krantz, Jennifer McCallum, Cheryl DeScipio, Maninder Kaur, Lynette A Gillis, Dinah Yaeger, Lori Jukofsky, Nora Wasserman, Armand Bottani, Colleen A Morris, Malgorzata J M Nowaczyk, Helga Toriello, Michael J Bamshad, John C Carey, Eric Rappaport, Shimako Kawauchi, Arthur D Lander, Anne L Calof, Hui-hua Li, Marcella Devoto and Laird G Jackson
Nature Genetics 36, 631–635
(June 2004); doi:10.1038/ng1364
| First Paragraph | Full Text (HTML/PDF) |
letter
NIPBL, encoding a homolog of fungal Scc2-type sister chromatid cohesion proteins and fly Nipped-B, is mutated in Cornelia de Lange syndrome
Emma T Tonkin, Tzu-Jou Wang, Steven Lisgo, Michael J Bamshad and Tom Strachan
Nature Genetics 36, 636–641
(June 2004); doi:10.1038/ng1363
| First Paragraph | Full Text (HTML/PDF) |
article
Dynein motors transport activated Trks to promote survival of target-dependent neurons
Heather M Heerssen, Maria F Pazyra and Rosalind A Segal
Nature Neuroscience 7, 596–604
(June 2004); doi:10.1038/nn1242
| Abstract | Full Text (HTML/PDF) |
article
The prepattern transcription factor Irx2, a target of the FGF8/MAP kinase cascade, is involved in cerebellum formation
Ken Matsumoto, Shigeki Nishihara, Mika Kamimura, Tomoki Shiraishi, Takao Otoguro, Masayuki Uehara, Yukiko Maeda, Keiko Ogura, Andrew Lumsden and Toshihiko Ogura
Nature Neuroscience 7, 605–612
(June 2004); doi:10.1038/nn1249
| Abstract | Full Text (HTML/PDF) |
article
Astrocytes contain a vesicular compartment that is competent for regulated exocytosis of glutamate
Paola Bezzi, Vidar Gundersen, José Luis Galbete, Gerald Seifert, Christian Steinhäuser, Ethel Pilati and Andrea Volterra
Nature Neuroscience 7, 613–620
(June 2004); doi:10.1038/nn1246
| Abstract | Full Text (HTML/PDF) |
review article
HIF1 and oxygen sensing in the brain
Frank R. Sharp and Myriam Bernaudin
Nature Reviews Neuroscience 5, 437–448
(June 2004); doi:10.1038/nrn1408
| Abstract | Full Text (HTML / PDF) |
research article
Chemical screening by mass spectrometry to identify inhibitors of anthrax lethal factor
Dal-Hee Min, Wei-Jen Tang and Milan Mrksich
Nature Biotechnology 22, 717–723
(June 2004); doi:10.1038/nbt973
| Abstract | Full Text (HTML/PDF) |
article
Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer
Julie A Clapperton, Isaac A Manke, Drew M Lowery, Timmy Ho, Lesley F Haire, Michael B Yaffe and Stephen J Smerdon
Nature Structural and Molecular Biology 11, 512–518
(June 2004); doi:10.1038/nsmb775
| Abstract | Full Text (HTML/PDF) |
article
Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1
R Scott Williams, Megan S Lee, D Duong Hau & J N Mark Glover
Nature Structural and Molecular Biology 11, 519–525
(June 2004); doi:10.1038/nsmb776
| Abstract | Full Text (HTML/PDF) |
brief communication
The stalk region of dynamin drives the constriction of dynamin tubes
Yen-Ju Chen, Peijun Zhang, Edward H Egelman and Jenny E Hinshaw
Nature Structural and Molecular Biology 11, 574–575
(June 2004); doi:10.1038/nsmb762
| First Paragraph | Full Text (HTML/PDF) |
article
Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy
Phil Oh, Yan Li, Jingyi Yu, Eberhard Durr, Karolina M. Krasinska, Lucy A. Carver, Jacqueline E. Testa and Jan E. Schnitzer
Nature 429, 629–635
(10 June 2004); doi:10.1038/nature02580
| Abstract | Full Text (HTML / PDF) |
news and views
Molecular medicine: The writing is on the vessel wall
Christopher H. Contag and Michael H. Bachmann
Nature 429, 618–619
(10 June 2004); doi:10.1038/429618a
| Full Text (HTML / PDF) |
letters to nature
Metabolic network analysis of the causes and evolution of enzyme dispensability in yeast
Balázs Papp, Csaba Pál and Laurence D. Hurst
Nature 429, 661–664
(10 June 2004); doi:10.1038/nature02636
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Myosin-dependent junction remodelling controls planar cell intercalation and axis elongation
Claire Bertet, Lawrence Sulak and Thomas Lecuit
Nature 429, 667–671
(10 June 2004); doi:10.1038/nature02590
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Structure of a complex between a voltage-gated calcium channel β-subunit and an α-subunit domain
Filip Van Petegem, Kimberly A. Clark, Franck C. Chatelain and Daniel L. Minor Jr
Nature 429, 671–675
(10 June 2004); doi:10.1038/nature02588
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Structural basis of the α1-β subunit interaction of voltage-gated Ca2+ channels
Yu-hang Chen, Ming-hui Li, Yun Zhang, Lin-ling He, Yoichi Yamada, Aileen Fitzmaurice, Yang Shen, Hailong Zhang, Liang Tong and Jian Yang
Nature 429, 675–680
(10 June 2004); doi:10.1038/nature02641
| First Paragraph | Full Text (HTML / PDF) |
article
Functional proteomic screens reveal an essential extracellular role for hsp90α in cancer cell invasiveness
Brenda K. Eustace, Takashi Sakurai, Jean K. Stewart, Dean Yimlamai, Christine Unger, Carol Zehetmeier, Blanca Lain, Claudia Torella, Stefan W. Henning, Gerald Beste, Bradley T. Scroggins, Len Neckers, Leodevico L. Ilag and Daniel G. Jay
Nature Cell Biology 6, 507–514
(June 2004); doi:10.1038/ncb1131
| Abstract | Full Text (HTML/PDF) |
news and views
Hsp90 invades the outside
Didier Picard
Nature Cell Biology 6, 479–480
(June 2004); doi:10.1038/ncb0604-479
| Full Text (HTML/PDF) |
letter
Myosin-X provides a motor-based link between integrins and the cytoskeleton
Hongquan Zhang, Jonathan S. Berg, Zhilun Li, Yunling Wang, Pernilla Lång, Aurea D. Sousa, Aparna Bhaskar, Richard E. Cheney and Staffan Strömblad
Nature Cell Biology 6, 523–531
(June 2004); doi:10.1038/ncb1136
| First Paragraph | Full Text (HTML/PDF) |
review article
Modulation of signalling by Sprouty: a developing story
Hong Joo Kim and Dafna Bar-Sagi
Nature Reviews Molecular Cell Biology 5, 441–450
(June 2004); doi:10.1038/nrm1400
| Abstract | Full Text (HTML / PDF) |
review article
Plant trichomes: a model for cell differentiation
Martin Hülskamp
Nature Reviews Molecular Cell Biology 5, 471–480
(June 2004); doi:10.1038/nrm1404
| Abstract | Full Text (HTML / PDF) |
article
Self-reactivity in thymic double-positive cells commits cells to a CD8αα lineage with characteristics of innate immune cells
Tetsuya Yamagata, Diane Mathis and Christophe Benoist
Nature Immunology 5, 597–605
(June 2004); doi:10.1038/ni1070
| Abstract | Full Text (HTML/PDF) |
news and views
Nondeletional pathways for the development of autoreactive thymocytes
Albert Bendelac
Nature Immunology 5, 557–558
(June 2004); doi:10.1038/ni0604-557
| Full Text (HTML/PDF) |
article
CD22 attenuates calcium signaling by potentiating plasma membrane calcium-ATPase activity
Jie Chen, Paul A McLean, Benjamin G Neel, Gbolahan Okunade, Gary E Shull and Henry H Wortis
Nature Immunology 5, 651–657
(June 2004); doi:10.1038/ni1072
| Abstract | Full Text (HTML/PDF) |
review article
Adhesion mechanisms regulating the migration of monocytes
Beat A. Imhof and Michel Aurrand-Lions
Nature Reviews Immunology 4, 432–444
(June 2004); doi:10.1038/nri1375
| Abstract | Full Text (HTML / PDF) |
article
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
Pradip K Majumder, Phillip G Febbo, Rachel Bikoff, Raanan Berger, Qi Xue, Louis M McMahon, Judith Manola, James Brugarolas, Timothy J McDonnell, Todd R Golub, Massimo Loda, Heidi A Lane and William R Sellers
Nature Medicine 10, 594–601
(June 2004); doi:10.1038/nm1052
| Abstract | Full Text (HTML/PDF) |
news and views
TORward AKTually useful mouse models
Ingo K Mellinghoff and Charles L Sawyers
Nature Medicine 10, 579–580
(June 2004); doi:10.1038/nm0604-579
| Full Text (HTML/PDF) |
review article
A renaissance for SRC
Timothy J. Yeatman
Nature Reviews Cancer 4, 470–480
(June 2004); doi:10.1038/nrc1366
| Abstract | Full Text (HTML / PDF) |
article
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
Brinda Ravikumar, Coralie Vacher, Zdenek Berger, Janet E Davies, Shouqing Luo, Lourdes G Oroz, Francesco Scaravilli, Douglas F Easton, Rainer Duden, Cahir J O'Kane and David C Rubinsztein
Nature Genetics 36, 585–595
(June 2004); doi:10.1038/ng1362
| Abstract | Full Text (HTML/PDF) |
news and views
Huntingtin aggregates ask to be eaten
Carson C Thoreen and David M Sabatini
Nature Genetics 36, 553–554
(June 2004); doi:10.1038/ng0604-553
| Full Text (HTML/PDF) |
brief communication
Frequency-dependent modulation of dopamine release by nicotine
Hui Zhang and David Sulzer
Nature Neuroscience 7, 581–582
(June 2004); doi:10.1038/nn1243
| First Paragraph | Full Text (HTML/PDF) |
brief communication
Nicotine amplifies reward-related dopamine signals in striatum
Margaret E Rice and Stephanie J Cragg
Nature Neuroscience 7, 583–584
(June 2004); doi:10.1038/nn1244
| First Paragraph | Full Text (HTML/PDF) |
perspectives
Neuregulin 1-erbB signaling and the molecular/cellular basis of schizophrenia
Gabriel Corfas, Kristine Roy and Joseph D Buxbaum
Nature Neuroscience 7, 575–580
(June 2004); doi:10.1038/nn1258
| Abstract | Full Text (HTML/PDF) |
research article
Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation
Ralph Brandenberger, Henry Wei, Sally Zhang, Shirley Lei, Jaji Murage, Gregory J Fisk, Yan Li, Chunhui Xu, Rixun Fang, Karl Guegler, Mahendra S Rao, Ramumkar Mandalam, Jane Lebkowski and Lawrence W Stanton
Nature Biotechnology 22, 707–716
(June 2004); doi:10.1038/nbt971
| Abstract | Full Text (HTML/PDF) |
news and views
A mightier mouse with human adaptive immunity
Marie H Kosco-Vilbois
Nature Biotechnology 22, 684–685
(June 2004); doi:10.1038/nbt0604-684
| Full Text (HTML/PDF) |
review article
GSK3 inhibitors: development and therapeutic potential
Philip Cohen and Michel Goedert
Nature Reviews Drug Discovery 3, 479–487
(June 2004); doi:10.1038/nrd1415
| Abstract | Full Text (HTML / PDF) |
article
Activity-dependent homeostatic specification of transmitter expression in embryonic neurons
Laura N. Borodinsky, Cory M. Root, Julia A. Cronin, Sharon B. Sann, Xiaonan Gu and Nicholas C. Spitzer
Nature 429, 523–530
(03 June 2004); doi:10.1038/nature02518
| Abstract | Full Text (HTML / PDF) |
news and views
Neurobiology: A matter of balance
Martyn Goulding
Nature 429, 515–517
(03 June 2004); doi:10.1038/429515a
| Full Text (HTML / PDF) |
letters to nature
Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body
Dae Sung Hwangbo, Boris Gersham, Meng-Ping Tu, Michael Palmer and Marc Tatar
Nature 429, 562–566
(03 June 2004); doi:10.1038/nature02549
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
The transcriptional programme of antibody class switching involves the repressor Bach2
Akihiko Muto, Satoshi Tashiro, Osamu Nakajima, Hideto Hoshino, Satoru Takahashi, Eiichirou Eakoda, Dai Ikebe, Masayuki Yamamoto & Kazuhiko Igarashi
Nature 429, 566–571
(03 June 2004); doi:10.1038/nature02596
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letters to nature
Intergenic transcription is required to repress the Saccharomyces cerevisiae SER3 gene
Joseph A. Martens, Lisa Laprade and Fred Winston
Nature 429, 571–574
(03 June 2004); doi:10.1038/nature02538
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news and views
Gene regulation: A reason for reading nonsense
Sabine Schmitt and Renato Paro
Nature 429, 510–511
(03 June 2004); doi:10.1038/429510a
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letters to nature
Cyclic electron flow around photosystem I is essential for photosynthesis
Yuri Munekage, Mihoko Hashimoto, Chikahiro Miyake, Ken-Ichi Tomizawa, Tsuyoshi Endo, Masao Tasaka and Toshiharu Shikanai
Nature 429, 579–582
(03 June 2004); doi:10.1038/nature02598
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article
Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II
Yunzeng Zou, Hiroshi Akazawa, Yingjie Qin, Masanori Sano, Hiroyuki Takano, Tohru Minamino, Noriko Makita, Koji Iwanaga, Weidong Zhu, Sumiyo Kudoh, Haruhiro Toko, Koichi Tamura, Minoru Kihara, Toshio Nagai, Akiyoshi Fukamizu, Satoshi Umemura, Taroh Iiri, Toshiro Fujita and Issei Komuro
Nature Cell Biology 6, 499–506
(June 2004); doi:10.1038/ncb1137
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letter
The endogenous ligand Stunted of the GPCR Methuselah extends lifespan in Drosophila
Svetlana Cvejic, Zheng Zhu, Sarah J. Felice, Yemiliya Berman and Xin-Yun Huang
Nature Cell Biology 6, 540–546
(June 2004); doi:10.1038/ncb1133
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news and views
Cdc14 phosphatase resolves the rDNA segregation delay
Gislene Pereira and Elmar Schiebel
Nature Cell Biology 6, 473–475
(June 2004); doi:10.1038/ncb0604-473
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review article
Polo-like kinases and the orchestration of cell division
Francis A. Barr, Herman H. W. Silljé and Erich A. Nigg
Nature Reviews Molecular Cell Biology 5, 429–441
(June 2004); doi:10.1038/nrm1401
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article
'Educated' dendritic cells act as messengers from memory to naive T helper cells
Oral Alpan, Eric Bachelder, Eda Isil, Heinz Arnheiter and Polly Matzinger
Nature Immunology 5, 615–622
(June 2004); doi:10.1038/ni1077
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news and views
Cutting into innate immunity
Astar Winoto
Nature Immunology 5, 563–564
(June 2004); doi:10.1038/ni0604-563
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review article
Mathematical and computational models of immune-receptor signalling
Byron Goldstein, James R. Faeder and William S. Hlavacek
Nature Reviews Immunology 4, 445–456
(June 2004); doi:10.1038/nri1374
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article
Selective inhibition of NF-kB blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo
Eijiro Jimi, Kazuhiro Aoki, Hiroaki Saito, Fulvio D'Acquisto, Michael J May, Ichiro Nakamura, Testuo Sudo, Takefumi Kojima, Fujio Okamoto, Hidefumi Fukushima, Koji Okabe, Keiichi Ohya and Sankar Ghosh
Nature Medicine 10, 617–624
(June 2004); doi:10.1038/nm1054
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article
cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury
Damien D Pearse, Francisco C Pereira, Alexander E Marcillo, Margaret L Bates, Yerko A Berrocal, Marie T Filbin and Mary Bartlett Bunge
Nature Medicine 10, 610–616
(June 2004); doi:10.1038/nm1056
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perspectives
Opinion: Yeast as a model system for anticancer drug discovery
Julian A. Simon and Antonio Bedalov
Nature Reviews Cancer 4, 481– 487
(June 2004); doi:10.1038/nrc1372
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letter
Hot-spot residue in small heat-shock protein 22 causes distal motor neuropathy
Joy Irobi, Katrien Van Impe, Pavel Seeman, Albena Jordanova, Ines Dierick, Nathalie Verpoorten, Andrej Michalik, Els De Vriendt, An Jacobs, Veerle Van Gerwen, Krist'l Vennekens, Radim Mazanec, Ivailo Tournev, David Hilton-Jones, Kevin Talbot, Ivo Kremensky, Ludo Van Den Bosch, Wim Robberecht, Joél Vandekerckhove, Christine Van Broeckhoven, Jan Gettemans, Peter De Jonghe and Vincent Timmerman
Nature Genetics 36, 597–601
(June 2004); doi:10.1038/ng1328
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letter
Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy
Oleg V Evgrafov, Irena Mersiyanova, Joy Irobi, Ludo Van Den Bosch, Ines Dierick, Conrad L Leung, Olga Schagina, Nathalie Verpoorten, Katrien Van Impe, Valeriy Fedotov, Elena Dadali, Michaela Auer-Grumbach, Christian Windpassinger, Klaus Wagner, Zoran Mitrovic, David Hilton-Jones, Kevin Talbot, Jean-Jacques Martin, Natalia Vasserman, Svetlana Tverskaya, Alexander Polyakov, Ronald K H Liem, Jan Gettemans, Wim Robberecht, Peter De Jonghe and Vincent Timmerman
Nature Genetics 36, 602–606
(June 2004); doi:10.1038/ng1354
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news and views
Shocking degeneration
Rainer Benndorf and Michael J Welsh
Nature Genetics 36, 547–548
(June 2004); doi:10.1038/ng0604-547
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article
Induction of PGE2 by estradiol mediates developmental masculinization of sex behavior
Stuart K Amateau and Margaret M McCarthy
Nature Neuroscience 7, 643–650
(June 2004); doi:10.1038/nn1254
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news and views
Brain gender: prostaglandins have their say
Erich N Ottem, Damian G Zuloaga and S Marc Breedlove
Nature Neuroscience 7, 570–572
(June 2004); doi:10.1038/nn0604-570
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review article
Merlin and the ERM proteins in Schwann cells, neurons and growth cones
Vijaya Ramesh
Nature Reviews Neuroscience 5, 462–470
(June 2004); doi:10.1038/nrn1407
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research article
Imaging the pharmacodynamics of HER2 degradation in response to Hsp90 inhibitors
Peter M Smith-Jones, David B Solit, Timothy Akhurst, Farzana Afroze, Neal Rosen and Steven M Larson
Nature Biotechnology 22, 701–706
(June 2004); doi:10.1038/nbt968
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news and views
An image worth a thousand lives?
Lisa A Hammond, Sean X Cavanaugh and Charles R Thomas Jr
Nature Biotechnology 22, 677–678
(June 2004); doi:10.1038/nbt0604-677
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review article
Targeted therapy for brain tumours
Maciej S. Lesniak and Henry Brem
Nature Reviews Drug Discovery 3, 499–508
(June 2004); doi:10.1038/nrd1414
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