The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.
Click here for free access to the 'Featured Articles' section, with new articles every week.
article Impaired PtdIns(4,5)P2 synthesis in nerve terminals produces defects in synaptic vesicle trafficking
Gilbert Di Paolo, Howard S. Moskowitz, Keith Gipson, Markus R. Wenk, Sergey Voronov, Masanori Obayashi, Richard Flavell, Reiko M. Fitzsimonds, Timothy A. Ryan and Pietro De Camilli Nature431, 415–422
(23 September 2004); doi:10.1038/nature02896
| Abstract | Full Text (HTML / PDF) |
letters to nature Regulation of B-cell survival by BAFF-dependent PKCδ-mediated nuclear signalling
Ingrid Mecklenbräuker, Susan L. Kalled, Michael Leitges, Fabienne Mackay and Alexander Tarakhovsky Nature431, 456–461
(23 September 2004); doi:10.1038/nature02955
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letters to nature NF-κB functions as a tumour promoter in inflammation-associated cancer
Eli Pikarsky, Rinnat M. Porat, Ilan Stein , Rinat Abramovitch, Sharon Amit, Shafika Kasem, Elena Gutkovich-Pyest, Simcha Urieli-Shoval, Eithan Galun and Yinon Ben-Neriah Nature431, 461–466
(23 September 2004); doi:10.1038/nature02924
| First Paragraph | Full Text (HTML / PDF) |
news and views Cancer: An inflammatory link
Fran Balkwill and Lisa M. Coussens Nature431, 405–406
(23 September 2004); doi:10.1038/431405a
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letters to nature Mrf4 determines skeletal muscle identity in Myf5:Myod double-mutant mice
Lina Kassar-Duchossoy, Barbara Gayraud-Morel, Danielle Gomès, Didier Rocancourt, Margaret Buckingham, Vasily Shinin and Shahragim Tajbakhsh Nature431, 466–471
(23 September 2004); doi:10.1038/nature02876
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letters to nature Exogenous control of mammalian gene expression through modulation of RNA self-cleavage
Laising Yen, Jennifer Svendsen, Jeng-Shin Lee, John T. Gray, Maxime Magnier, Takashi Baba, Robert J. D'Amato and Richard C. Mulligan Nature431, 471–476
(23 September 2004); doi:10.1038/nature02844
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news and views Biological techniques: Tailor-made riboswitches
Angela K. Eggleston Nature431, 409
(23 September 2004); doi:10.1038/431409a
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article Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function
Yanyan Hao, Keiko Sekine, Atsushi Kawabata, Hitoshi Nakamura, Toshiyasu Ishioka, Hirokazu Ohata, Ryohei Katayama, Chizuko Hashimoto, Xiaodong Zhang, Tetsuo Noda, Takashi Tsuruo and Mikihiko Naito Nature Cell Biology6, 849–860
(September 2004); doi:10.1038/ncb1159
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news and views An Apollon vista of death and destruction
Seamus J. Martin Nature Cell Biology6, 804–806
(September 2004); doi:10.1038/ncb0904-804
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letter Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase
Alwin Krämer, Niels Mailand, Claudia Lukas, Randi G. Syljuåsen, Christopher J. Wilkinson, Erich A. Nigg, Jiri Bartek and Jiri Lukas Nature Cell Biology6, 884–891
(September 2004); doi:10.1038/ncb1165
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news and views Stretching cell fate
Donald McDonald Nature Cell Biology6, 803
(September 2004); doi:10.1038/ncb0904-803
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review article The abc's (and xyz's) of peptide sequencing
Hanno Steen and Matthias Mann Nature Reviews Molecular Cell Biology5, 699–711
(September 2004); doi:10.1038/nrm1468
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review article The SCF ubiquitin ligase: insights into a molecular machine
Timothy Cardozo and Michele Pagano Nature Reviews Molecular Cell Biology5, 739–751
(September 2004); doi:10.1038/nrm1471
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article RhoH is required to maintain the integrin LFA-1 in a nonadhesive state on lymphocytes
Lisa K Cherry, Xiaoyu Li, Pascale Schwab, Bing Lim and Lloyd B Klickstein Nature Immunology5, 961–967
(September 2004); doi:10.1038/ni1103
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review article T-cell trafficking in asthma: lipid mediators grease the way
Andrew D. Luster and Andrew M. Tager Nature Reviews Immunology4, 711–724
(September 2004); doi:10.1038/nri1438
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article Role of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunity
Juan E Moyron-Quiroz, Javier Rangel-Moreno, Kim Kusser, Louise Hartson, Frank Sprague, Stephen Goodrich, David L Woodland, Frances E Lund and Troy D Randall Nature Medicine10, 927–934
(September 2004); doi:10.1038/nm1091
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news and views Lung immunity: necessity is the mother of induction
Max Corbett and Jean-Pierre Kraehenbuhl Nature Medicine10, 904–905
(September 2004); doi:10.1038/nm0904-904
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article Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
Tyler J Curiel, George Coukos, Linhua Zou, Xavier Alvarez, Pui Cheng, Peter Mottram, Melina Evdemon-Hogan, Jose R Conejo-Garcia, Lin Zhang, Matthew Burow, Yun Zhu, Shuang Wei, Ilona Kryczek, Ben Daniel, Alan Gordon, Leann Myers, Andrew Lackner, Mary L Disis, Keith L Knutson, Lieping Chen and Weiping Zou Nature Medicine10, 942–949
(September 2004); doi:10.1038/nm1093
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news and views Fatal attraction: tumors beckon regulatory T cells
Ethan M Shevach Nature Medicine10, 900–901
(September 2004); doi:10.1038/nm0904-900
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article Tumor-infiltrating dendritic cell precursors recruited by a β-defensin contribute to vasculogenesis under the influence of Vegf-A
Jose R Conejo-Garcia, Fabian Benencia, Maria-Cecilia Courreges, Eugene Kang, Alisha Mohamed-Hadley, Ronald J Buckanovich, David O Holtz, Ann Jenkins, Hana Na, Lin Zhang, Daniel S Wagner, Dionyssios Katsaros, Richard Caroll and George Coukos Nature Medicine10, 950–958
(September 2004); doi:10.1038/nm1097
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article Reticulon family members modulate BACE1 activity and amyloid-β peptide generation
Wanxia He, Yifeng Lu, Isam Qahwash, Xiang-You Hu, Ansi Chang and Riqiang Yan Nature Medicine10, 959–965
(September 2004); doi:10.1038/nm1088
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news and views Epithelial cells pay a Toll for protection
Warren Strober Nature Medicine10, 898–900
(September 2004); doi:10.1038/nm0904-898
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news and views Mutated matrix gene mars macula
Charlotte Schubert Nature Medicine10, 903
(September 2004); doi:10.1038/nm0904-903
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news and views Maiming mitochondria in familial ALS
Valina L Dawson Nature Medicine10, 905–906
(September 2004); doi:10.1038/nm0904-905
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review article Oncogenic mechanisms of the Helicobacter pylori CagA protein
Masanori Hatakeyama Nature Reviews Cancer4, 688–694
(September 2004); doi:10.1038/nrc1433
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review article Gallbladder cancer: lessons from a rare tumour
Ignacio I. Wistuba and Adi F. Gazdar Nature Reviews Cancer4, 695–706
(September 2004); doi:10.1038/nrc1429
| Abstract | Full Text (HTML / PDF) |
perspectives Opinion: Transcription — guarding the genome by sensing DNA damage
Mats Ljungman and David P. Lane Nature Reviews Cancer4, 727–737
(September 2004); doi:10.1038/nrc1435
| Abstract | Full Text (HTML / PDF) |
news and views From mRNA to tumor suppressor
Dan Mercola and John Welsh Nature Genetics36, 937–938
(September 2004); doi:10.1038/ng0904-937
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letter Loss of BBS proteins causes anosmia in humans and defects in olfactory cilia structure and function in the mouse
Heather M Kulaga, Carmen C Leitch, Erica R Eichers, Jose L Badano, Alysa Lesemann, Bethan E Hoskins, James R Lupski, Philip L Beales, Randall R Reed and Nicholas Katsanis Nature Genetics36, 994–998
(September 2004); doi:10.1038/ng1418
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letter Mutations in SLC6A19, encoding B0AT1, cause Hartnup disorder
Robert Kleta, Elisa Romeo, Zorica Ristic, Toshihiro Ohura, Caroline Stuart, Mauricio Arcos-Burgos, Mital H Dave, Carsten A Wagner, Simone R M Camargo, Sumiko Inoue, Norio Matsuura, Amanda Helip-Wooley, Detlef Bockenhauer, Richard Warth, Isa Bernardini, Gepke Visser, Thomas Eggermann, Philip Lee, Arthit Chairoungdua, Promsuk Jutabha, Ellappan Babu, Sirinun Nilwarangkoon, Naohiko Anzai, Yoshikatsu Kanai, Francois Verrey, William A Gahl and Akio Koizumi Nature Genetics36, 999–1002
(September 2004); doi:10.1038/ng1405
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letter Hartnup disorder is caused by mutations in the gene encoding the neutral amino acid transporter SLC6A19
Heng F Seow, Stefan Bröer, Angelika Bröer, Charles G Bailey, Simon J Potter, Juleen A Cavanaugh and John E J Rasko Nature Genetics36, 1003–1007
(September 2004); doi:10.1038/ng1406
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letter Evidence for a fruit fly hemangioblast and similarities between lymph-gland hematopoiesis in fruit fly and mammal aorta-gonadal-mesonephros mesoderm
Lolitika Mandal, Utpal Banerjee and Volker Hartenstein Nature Genetics36, 1019–1023
(September 2004); doi:10.1038/ng1404
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article The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity
Jens C Schwamborn and Andreas W Püschel Nature Neuroscience7, 923–929
(September 2004); doi:10.1038/nn1295
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technical report Differentiation of mouse embryonic stem cells into a defined neuronal lineage
Miriam Bibel, Jens Richter, Katrin Schrenk, Kerry Lee Tucker, Volker Staiger, Martin Korte, Magdalena Goetz and Yves-Alain Barde Nature Neuroscience7, 1003–1009
(September 2004); doi:10.1038/nn1301
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brief communication Lateral organization of endocytic machinery in dendritic spines
Bence Rácz, Thomas A Blanpied, Michael D Ehlers and Richard J Weinberg Nature Neuroscience7, 917–918
(September 2004); doi:10.1038/nn1303
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review article Molecular and neuronal substrates for general anaesthetics
Uwe Rudolph and Bernd Antkowiak Nature Reviews Neuroscience5, 709–720
(September 2004); doi:10.1038/nrn1496
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research article Temporal analysis of phosphotyrosine-dependent signaling networks by quantitative proteomics
Blagoy Blagoev, Shao-En Ong, Irina Kratchmarova and Matthias Mann Nature Biotechnology22, 1139–1145
(September 2004); doi:10.1038/nbt1005
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news and views Phosphoproteomics finds its timing
Sam A Johnson and Tony Hunter Nature Biotechnology22, 1093–1094
(September 2004); doi:10.1038/nbt0904-1093
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research article Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages
Raewyn M Seaberg, Simon R Smukler, Timothy J Kieffer, Grigori Enikolopov, Zeenat Asghar, Michael B Wheeler, Gregory Korbutt and Derek van der Kooy Nature Biotechnology22, 1115–1124
(September 2004); doi:10.1038/nbt1004
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news and views β-cell precursors—a work in progress
Gordon C Weir and Susan Bonner-Weir Nature Biotechnology22, 1095–1096
(September 2004); doi:10.1038/nbt0904-1095
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article Mechanochemical coupling of two substeps in a single myosin V motor
Sotaro Uemura, Hideo Higuchi, Adrian O Olivares, Enrique M De La Cruz and Shin'ichi Ishiwata Nature Structural and Molecular Biology11, 877–883
(September 2004); doi:10.1038/nsmb806
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article Myosin VI walks hand-over-hand along actin
Zeynep Ökten, L Stirling Churchman, Ronald S Rock and James A Spudich Nature Structural and Molecular Biology11, 884–887
(September 2004); doi:10.1038/nsmb815
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review article The endocannabinoid system and its therapeutic exploitation
Vincenzo Di Marzo, Maurizio Bifulco and Luciano De Petrocellis Nature Reviews Drug Discovery3, 771–784
(September 2004); doi:10.1038/nrd1495
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letters to nature Genomic analysis of regulatory network dynamics reveals large topological changes
Nicholas M. Luscombe, M. Madan Babu, Haiyuan Yu, Michael Snyder, Sarah A. Teichmann and Mark Gerstein Nature431, 308–312
(16 September 2004); doi:10.1038/nature02782
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letters to nature Long-lasting self-inhibition of neocortical interneurons mediated by endocannabinoids
Alberto Bacci, John R. Huguenard and David A. Prince Nature431, 312–316
(16 September 2004); doi:10.1038/nature02913
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letters to nature Conserved mechanisms of glucose sensing and regulation by Drosophila corpora cardiaca cells
Seung K. Kim and Eric J. Rulifson Nature431, 316–320
(16 September 2004); doi:10.1038/nature02897
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letters to nature Spermatid differentiation requires the assembly of a cell polarity complex downstream of junctional adhesion molecule-C
Georgia Gliki, Klaus Ebnet, Michel Aurrand-Lions, Beat A. Imhof and Ralf H. Adams Nature431, 320–324
(16 September 2004); doi:10.1038/nature02877
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letters to nature A microtubule-binding myosin required for nuclear anchoring and spindle assembly
Kari L. Weber, Anna M. Sokac , Jonathan S. Berg, Richard E. Cheney and William M. Bement Nature431, 325–329
(16 September 2004); doi:10.1038/nature02834
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news and views Cell biology: Myosins meet microtubules
Margaret A. Titus Nature431, 252–253
(16 September 2004); doi:10.1038/431252a
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letters to nature Direct charging of tRNACUA with pyrrolysine in vitro and in vivo
Sherry K. Blight, Ross C. Larue, Anirban Mahapatra, David G. Longstaff, Edward Chang, Gang Zhao, Patrick T. Kang, Kari B. Green-Church, Michael K. Chan and Joseph A. Krzycki Nature431, 333–335
(16 September 2004); doi:10.1038/nature02895
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news and views Molecular biology: Genetic code seizes pyrrolysine
Paul Schimmel and Kirk Beebe Nature431, 257–258
(16 September 2004); doi:10.1038/431257a
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article Control of vesicle fusion by a tyrosine phosphatase
Huong Huynh, Nunzio Bottini, Scott Williams, Vera Cherepanov, Lucia Musumeci, Kan Saito, Shane Bruckner, Eric Vachon, Xiaodong Wang, Joshua Kruger, Chung-Wai Chow, Maurizio Pellecchia, Edvard Monosov, Peter A. Greer, William Trimble, Gregory P. Downey and Tomas Mustelin Nature Cell Biology6, 831–839
(September 2004); doi:10.1038/ncb1164
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article Dynactin is involved in a checkpoint to monitor cell wall synthesis in Saccharomyces cerevisiae
Masaya Suzuki, Ryoji Igarashi, Mizuho Sekiya, Takahiko Utsugi, Shinichi Morishita, Masashi Yukawa and Yoshikazu Ohya Nature Cell Biology6, 861–871
(September 2004); doi:10.1038/ncb1162
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news and views A new checkpoint takes shape
M. Andrew Hoyt Nature Cell Biology6, 801–803
(September 2004); doi:10.1038/ncb0904-801
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review article From structure to disease: the evolving tale of aquaporin biology
Landon S. King, David Kozono and Peter Agre Nature Reviews Molecular Cell Biology5, 687–698
(September 2004); doi:10.1038/nrm1469
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article MHC class II expression is differentially regulated in plasmacytoid and conventional dendritic cells
Salomé LeibundGut-Landmann, Jean-Marc Waldburger, Caetano Reis e Sousa, Hans Acha-Orbea and Walter Reith Nature Immunology5, 899–908
(September 2004); doi:10.1038/ni1109
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article Upregulation of the CLIP self peptide on mature dendritic cells antagonizes T helper type 1 polarization
Till A Röhn, Marianne Boes, Dirk Wolters, Sebastian Spindeldreher, Bernd Müller, Hanno Langen, Hidde Ploegh, Anne B Vogt and Harald Kropshofer Nature Immunology5, 909–918
(September 2004); doi:10.1038/ni1108
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review article E3 ubiquitin ligases as T cell anergy factors
Daniel L Mueller Nature Immunology5, 883–890
(September 2004); doi:10.1038/ni1106
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review article TCR ζ-chain downregulation: curtailing an excessive inflammatory immune response
Michal Baniyash Nature Reviews Immunology4, 675–687
(September 2004); doi:10.1038/nri1434
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article Degenerate self-reactive human T-cell receptor causes spontaneous autoimmune disease in mice
Sonia Quaratino, Ester Badami, Yun Yun Pang, Istvan Bartok, Julian Dyson, Dimitris Kioussis, Marco Londei and Luigi Maiuri Nature Medicine10, 920–926
(September 2004); doi:10.1038/nm1092
| Abstract | Full Text (HTML/PDF) |
news and views Autoimmune hypothyroidism: T cells caught in the act
Sandra M McLachlan and Basil Rapoport Nature Medicine10, 895–896
(September 2004); doi:10.1038/nm0904-895
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article Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis
Tatiana V Petrova, Terhi Karpanen, Camilla Norrmén, Russell Mellor, Tomoki Tamakoshi, David Finegold, Robert Ferrell, Dontscho Kerjaschki, Peter Mortimer, Seppo Ylä-Herttuala, Naoyuki Miura and Kari Alitalo Nature Medicine10, 974–981
(September 2004); doi:10.1038/nm1094
| Abstract | Full Text (HTML/PDF) |
technical report Tracking metastatic tumor cell extravasation with quantum dot nanocrystals and fluorescence emission-scanning microscopy
Evelyn B Voura, Jyoti K Jaiswal, Hedi Mattoussi and Sanford M Simon Nature Medicine10, 993–998
(September 2004); doi:10.1038/nm1096
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review article Gene-promoter hypermethylation as a biomarker in lung cancer
Steven A. Belinsky Nature Reviews Cancer4, 707–717
(September 2004); doi:10.1038/nrc1432
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article Abnormal TNF activity in Timp3−/− mice leads to chronic hepatic inflammation and failure of liver regeneration
Fazilat F Mohammed, David S Smookler, Suzanne E M Taylor, Barbara Fingleton, Zamaneh Kassiri, Otto H Sanchez, Jane L English, Lynn M Matrisian, Billie Au, Wen-Chen Yeh and Rama Khokha Nature Genetics36, 969–977
(September 2004); doi:10.1038/ng1413
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news and views TIMP3 checks inflammation
Roy A Black Nature Genetics36, 934–935
(September 2004); doi:10.1038/ng0904-934
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perspectives Opinion: Genetically modified mouse models for pharmacogenomic research
Stephen B. Liggett Nature Reviews Genetics5, 657–663
(September 2004); doi:10.1038/nrg1429
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news and views From neurotoxin to neurotrophin
Christian Mirescu and Elizabeth Gould Nature Neuroscience7, 899–900
(September 2004); doi:10.1038/nn0904-899
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article PI3K promotes voltage-dependent calcium channel trafficking to the plasma membrane
Patricia Viard, Adrian J Butcher, Guillaume Halet, Anthony Davies, Bernd Nürnberg, Fay Heblich and Annette C Dolphin Nature Neuroscience7, 939–946
(September 2004); doi:10.1038/nn1300
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review article Adult neuron survival strategies — slamming on the brakes
Susanna C. Benn and Clifford J. Woolf Nature Reviews Neuroscience5, 686–700
(September 2004); doi:10.1038/nrn1477
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news and views High-throughput biochemistry heats up
F Raymond Salemme Nature Biotechnology22, 1100–1101
(September 2004); doi:10.1038/nbt0904-1100
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article CBFβ allosterically regulates the Runx1 Runt domain via a dynamic conformational equilibrium
Jiangli Yan, Yizhou Liu, Stephen M Lukasik, Nancy A Speck and John H Bushweller Nature Structural and Molecular Biology11, 901–906
(September 2004); doi:10.1038/nsmb819
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article Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton
Anjon Audhya, Robbie Loewith, Ainslie B Parsons, Lu Gao, Mitsuaki Tabuchi1, Huilin Zhou, Charles Boone, Michael N Hall and Scott D Emr The EMBO Journal Advanced Online Publication
(September 2004); doi:10.1038/sj.emboj.7600384
| Abstract | Full Text (HTML/PDF) |
letters to nature Calcium transients in astrocyte endfeet cause cerebrovascular constrictions
Sean J. Mulligan and Brian A. MacVicar Nature431, 195–199
(09 September 2004); doi:10.1038/nature02827
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news and views Neurobiology: Feeding the brain
Claire Peppiatt and David Attwell Nature431, 137–138
(09 September 2004); doi:10.1038/431137a
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letters to nature Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
Sung Hee Um, Francesca Frigerio, Mitsuhiro Watanabe, Frédéric Picard, Manel Joaquin, Melanie Sticker, Stefano Fumagalli, Peter R. Allegrini, Sara C. Kozma, Johan Auwerx and George Thomas Nature431, 200–205
(09 September 2004); doi:10.1038/nature02866
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letters to nature Cytoplasmic PML function in TGF-β signalling
Hui-Kuan Lin, Stephan Bergmann and Pier Paolo Pandolfi Nature431, 205–211
(09 September 2004); doi:10.1038/nature02783
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news and views Cell biology: An unexpected social servant
Christine Le Roy and Jeffrey L. Wrana Nature431, 142
(09 September 2004); doi:10.1038/431142a
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letters to nature Structure of the ESCRT-II endosomal trafficking complex
Aitor Hierro, Ji Sun, Alexander S. Rusnak, Jaewon Kim, Gali Prag, Scott D. Emr and James H. Hurley Nature431, 221–226
(09 September 2004); doi:10.1038/nature02914
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article Yeast centrin Cdc31 is linked to the nuclear mRNA export machinery
Tamás Fischer, Susana Rodríguez-Navarro, Gislene Pereira, Attila Rácz, Elmar Schiebel and Ed Hurt Nature Cell Biology6, 840–848
(September 2004); doi:10.1038/ncb1163
| Abstract | Full Text (HTML/PDF) |
news and views Spindle checkpoint protein links Rb pathway to aneuploidy
Bernd Pulverer Nature Cell Biology6, 806
(September 2004); doi:10.1038/ncb0904-806
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review article Plasmodesmata as a supracellular control network in plants
William J. Lucas and Jung-Youn Lee Nature Reviews Molecular Cell Biology5, 712–726
(September 2004); doi:10.1038/nrm1470
| Abstract | Full Text (HTML / PDF) |
review article Cell signalling and the control of pre-mRNA splicing
Chanseok Shin and James L. Manley Nature Reviews Molecular Cell Biology5, 727–738
(September 2004); doi:10.1038/nrm1467
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article PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity
Bin Liu, Sheldon Mink, Kelly A Wong, Natalie Stein, Crescent Getman, Paul W Dempsey, Hong Wu and Ke Shuai Nature Immunology5, 891–898
(September 2004); doi:10.1038/ni1104
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news and views A peek at PIAS
John J O'Shea and Wendy Watford Nature Immunology5, 875–876
(September 2004); doi:10.1038/ni0904-875
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review article Nalt- versus peyer's-patch-mediated mucosal immunity
Hiroshi Kiyono and Satoshi Fukuyama Nature Reviews Immunology4, 699–710
(September 2004); doi:10.1038/nri1439
| Abstract | Full Text (HTML / PDF) |
letter CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation
Jill R Crittenden, Wolfgang Bergmeier, Yanyu Zhang, Crystal L Piffath, Yuqiong Liang, Denisa D Wagner, David E Housman and Ann M Graybiel Nature Medicine10, 982–986
(September 2004); doi:10.1038/nm1098
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brief communication The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer
Héctor G Pálmer, María Jesús Larriba, José Miguel García, Paloma Ordóñez-Morán, Cristina Peña, Sandra Peiró, Isabel Puig, Rufo Rodríguez, Ricardo de la Fuente, Antonio Bernad, Marina Pollán, Félix Bonilla, Carlos Gamallo, Antonio García de Herreros and Alberto Muñoz Nature Medicine10, 917–919
(September 2004); doi:10.1038/nm1095
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review article BRCA1 and BRCA2: 1994 and beyond
Steven A. Narod and William D. Foulkes Nature Reviews Cancer4, 665–676
(September 2004); doi:10.1038/nrc1431
| Abstract | Full Text (HTML / PDF) |
article Effects of G-protein mutations on skin color
Catherine D Van Raamsdonk, Karen R Fitch, Helmut Fuchs, Martin Hrabé de Angelis and Gregory S Barsh Nature Genetics36, 961–968
(September 2004); doi:10.1038/ng1412
| Abstract | Full Text (HTML/PDF) |
news and views The G-netics of dark skin
Ian J Jackson Nature Genetics36, 935–936
(September 2004); doi:10.1038/ng0904-935
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review article WNT and β-catenin signalling: diseases and therapies
Randall T. Moon, Aimee D. Kohn, Giancarlo V. De Ferrari and Ajamete Kaykas Nature Reviews Genetics5, 691–701
(September 2004); doi:10.1038/nrg1427
| Abstract | Full Text (HTML / PDF) |
article Aβ is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis
Martin C Herzig, David T Winkler, Patrick Burgermeister, Michelle Pfeifer, Esther Kohler, Stephen D Schmidt, Simone Danner, Dorothee Abramowski, Christine Stürchler-Pierrat, Kurt Bürki, Sjoerd G van Duinen, Marion L C Maat-Schieman, Matthias Staufenbiel, Paul M Mathews and Mathias Jucker Nature Neuroscience7, 954–960
(September 2004); doi:10.1038/nn1302
| Abstract | Full Text (HTML/PDF) |
news and views An animal model of vascular amyloidosis
Jorge Ghiso and Thomas Wisniewski Nature Neuroscience7, 902–904
(September 2004); doi:10.1038/nn0904-902
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review article Strategies for disease modification in Alzheimer's disease
Martin Citron Nature Reviews Neuroscience5, 677–685
(September 2004); doi:10.1038/nrn1495
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research article A simple method to cure established tumors by inflammatory killing of normal cells
Gregory A Daniels, Luis Sanchez-Perez, Rosa Maria Diaz, Timothy Kottke, Jill Thompson, Maoyi Lai, Michael Gough, Mahzuz Karim, Andrew Bushell, Heung Chong, Alan Melcher, Kevin Harrington and Richard G Vile Nature Biotechnology22, 1125–1132
(September 2004); doi:10.1038/nbt1007
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news and views Immunotherapy dispenses with tumor antigens
Soldano Ferrone Nature Biotechnology22, 1096–1098
(September 2004); doi:10.1038/nbt0904-1096
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article Structural basis for the evolutionary inactivation of Ca2+ binding to synaptotagmin 4
Han Dai, Ok-Ho Shin, Mischa Machius, Diana R Tomchick, Thomas C Südhof and Josep Rizo Nature Structural and Molecular Biology11, 844–849
(September 2004); doi:10.1038/nsmb817
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letters to nature Reading the Hedgehog morphogen gradient by measuring the ratio of bound to unbound Patched protein
Andreu Casali and Gary Struhl Nature431, 76–80
(02 September 2004); doi:10.1038/nature02835
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letters to nature Netrin–1 controls colorectal tumorigenesis by regulating apoptosis
Laetitia Mazelin, Agnès Bernet, Christelle Bonod–Bidaud, Laurent Pays, Ségolène Arnaud, Christian Gespach, Dale E Bredesen, Jean–Yves Scoazec and Patrick Mehlen Nature431, 80–84
(02 September 2004); doi:10.1038/nature02788
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news and views Cancer: Cell survival guide
Eric R. Fearon and Kathleen R. Cho Nature431, 35–36
(02 September 2004); doi:10.1038/431035a
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letters to nature A glycolipid of hypervirulent tuberculosis strains that inhibits the innate immune response
Michael B. Reed, Pilar Domenech, Claudia Manca, Hua Su, Amy K. Barczak, Barry N. Kreiswirth, Gilla Kaplan and Clifton E. Barry III Nature431, 84–87
(02 September 2004); doi:10.1038/nature02837
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letters to nature Involvement of targeted proteolysis in plant genetic transformation by Agrobacterium
Tzvi Tzfira, Manjusha Vaidya and Vitaly Citovsky Nature431, 87–92
(02 September 2004); doi:10.1038/nature02857
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letters to nature Centrosomes direct cell polarity independently of microtubule assembly in C. elegans embryos
Carrie R. Cowan and Anthony A. Hyman Nature431, 92–96
(02 September 2004); doi:10.1038/nature02825
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letters to nature Transcriptional regulatory code of a eukaryotic genome
Christopher T. Harbison, D. Benjamin Gordon, Tong Ihn Lee, Nicola J. Rinaldi, Kenzie D. Macisaac, Timothy W. Danford, Nancy M. Hannett, Jean–Bosco Tagne, David B. Reynolds, Jane Yoo, Ezra G. Jennings, Julia Zeitlinger, Dmitry K. Pokholok, Manolis Kellis, P. Alex Rolfe, Ken T. Takusagawa, Eric S. Lander, David K. Gifford, Ernest Fraenkel and Richard A. Young Nature431, 99–104
(02 September 2004); doi:10.1038/nature02800
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news and views Cell biology: Regulated self–cannibalism
Daniel J. Klionsky Nature431, 31–32
(02 September 2004); doi:10.1038/431031a
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article EB1 and APC bind to mDia to stabilize microtubules downstream of Rho and promote cell migration
Ying Wen, Christina H. Eng, Jan Schmoranzer, Noemi Cabrera–Poch, Edward J. S. Morris, Michael Chen, Bradley J. Wallar, Arthur S. Alberts and Gregg G. Gundersen Nature Cell Biology6, 820–830
(September 2004); doi:10.1038/ncb1160
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news and views Unravelling Ras signals in cardiovascular disease
Kenneth R. Chien and Masahiko Hoshijima Nature Cell Biology6, 807–808
(September 2004); doi:10.1038/ncb0904–807
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review article Apoptosis and genomic instability
Boris Zhivotovsky and Guido Kroemer Nature Reviews Molecular Cell Biology5, 752–762
(September 2004); doi:10.1038/nrm1443
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article Serine protease inhibitor 2A is a protective factor for memory T cell development
Ni Liu, Tiphanie Phillips, Manling Zhang, Yue Wang, Joseph T Opferman, Ramila Shah and Philip G Ashton–Rickardt Nature Immunology5, 919–926
(September 2004); doi:10.1038/ni1107
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article Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5
Christopher D C Allen, K Mark Ansel, Caroline Low, Robin Lesley, Hirokazu Tamamura, Nobutaka Fujii and Jason G Cyster Nature Immunology5, 943–952
(September 2004); doi:10.1038/ni1100
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review article Tolerance, not immunity, crucially depends on IL–2
Thomas R. Malek and Allison L. Bayer Nature Reviews Immunology4, 665–674
(September 2004); doi:10.1038/nri1435
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article The 5–lipoxygenase pathway promotes pathogenesis of hyperlipidemia–dependent aortic aneurysm
Lei Zhao, Michael P W Moos, Rolf Gräbner, Frédérique Pédrono, Jinjin Fan, Brigitte Kaiser, Nicole John, Sandra Schmidt, Rainer Spanbroek, Katharina Lötzer, Li Huang, Jisong Cui, Daniel J Rader, Jilly F Evans, Andreas J R Habenicht and Colin D Funk Nature Medicine10, 966–973
(September 2004); doi:10.1038/nm1099
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news and views Aneurysms: leukotrienes weaken aorta from the outside
Wulf Palinski Nature Medicine10, 896–898
(September 2004); doi:10.1038/nm0904–896
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perspectives Opinion: Switching on kinases: oncogenic activation of BRAF and the PDGFR family
Nick J. Dibb, Stephen M. Dilworth and Clifford D. Mol Nature Reviews Cancer4, 718–727
(September 2004); doi:10.1038/nrc1434
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letter Mutations in a member of the Ras superfamily of small GTP–binding proteins causes Bardet–Biedl syndrome
Yanli Fan, Muneer A Esmail, Stephen J Ansley, Oliver E Blacque, Keith Boroevich, Alison J Ross, Susan J Moore, Jose L Badano, Helen May–Simera, Deanna S Compton, Jane S Green, Richard Alan Lewis, Mieke M van Haelst, Patrick S Parfrey, David L Baillie, Philip L Beales, Nicholas Katsanis, William S Davidson and Michel R Leroux Nature Genetics36, 989–993
(September 2004); doi:10.1038/ng1414
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letter Nonsense–mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer
Pia Huusko, Damaris Ponciano–Jackson, Maija Wolf, Jeff A Kiefer, David O Azorsa, Sukru Tuzmen, Don Weaver, Christiane Robbins, Tracy Moses, Minna Allinen, Sampsa Hautaniemi, Yidong Chen, Abdel Elkahloun, Mark Basik, G Steven Bova, Lukas Bubendorf, Alessandro Lugli, Guido Sauter, Johanna Schleutker, Hilmi Ozcelik, Sabine Elowe, Tony Pawson, Jeffrey M Trent, John D Carpten, Olli–P Kallioniemi and Spyro Mousses Nature Genetics36, 979–983
(September 2004); doi:10.1038/ng1408
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article Restructuring the neuronal stress response with anti–glucocorticoid gene delivery
D Kaufer, W O Ogle, Z S Pincus, K L Clark, A C Nicholas, K M Dinkel, T C Dumas, D Ferguson, A L Lee, M A Winters and R M Sapolsky Nature Neuroscience7, 947–953
(September 2004); doi:10.1038/nn1296
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research article Rapid and ultra–sensitive determination of enzyme activities using surface–enhanced resonance Raman scattering
Barry D Moore, Lorna Stevenson, Alan Watt, Sabine Flitsch, Nicolas J Turner, Chris Cassidy and Duncan Graham Nature Biotechnology22, 1133–1138
(September 2004); doi:10.1038/nbt1003
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news and views Finding enzymatic gold on silver surfaces
Uwe T Bornscheuer Nature Biotechnology22, 1098–1099
(September 2004); doi:10.1038/nbt0904–1098
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article An unstructured initiation site is required for efficient proteasome–mediated degradation
Sumit Prakash, Lin Tian, Kevin S Ratliff, Rebecca E Lehotzky and Andreas Matouschek Nature Structural and Molecular Biology11, 830–837
(September 2004); doi:10.1038/nsmb814
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news and views Signaling degradation
Jon A Kenniston and Robert T Sauer Nature Structural and Molecular Biology11, 800–802
(September 2004); doi:10.1038/nsmb0904–800
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