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The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.
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article
Structure of the bacterial flagellar hook and implication for the molecular universal joint mechanism
Fadel A. Samatey , Hideyuki Matsunami , Katsumi Imada , Shigehiro Nagashima, Tanvir R. Shaikh, Dennis R. Thomas, James Z. Chen, David J. DeRosier, Akio Kitao and Keiichi Namba
Nature 431, 1062–1068
(28 October 2004); doi:10.1038/nature02997
| Abstract | Full Text (HTML / PDF) |
news and views
Molecular motors: Smooth coupling in Salmonella
Christopher Surridge
Nature 431, 1047
(28 October 2004); doi:10.1038/4311047b
| Full Text (HTML / PDF) |
letters to nature
MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer
Catherine M. Shachaf, Andrew M. Kopelman, Constadina Arvanitis, Åsa Karlsson, Shelly Beer, Stefanie Mandl, Michael H. Bachmann, Alexander D. Borowsky, Boris Ruebner, Robert D. Cardiff, Qiwei Yang, J. Michael Bishop, Christopher H. Contag and Dean W. Felsher
Nature 431, 1112–1117
(28 October 2004); doi:10.1038/nature03043
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Phosphorylation-dependent binding of mitotic cyclins to Cdc6 contributes to DNA replication control
Satoru Mimura, Takashi Seki, Seiji Tanaka and John F. X. Diffley
Nature 431, 1118–1123
(28 October 2004); doi:10.1038/nature03024
| First Paragraph | Full Text (HTML / PDF) |
letter
DNA demethylation is necessary for the epigenetic reprogramming of somatic cell nuclei
Stina Simonsson and John Gurdon
Nature Cell Biology 6, 984–990
(October 2004); doi:10.1038/ncb1176
| First Paragraph | Full Text (HTML/PDF) |
news and views
Nuclear transfer: Epigenetics pays a visit
Naoyuki Fujita and Paul A. Wade
Nature Cell Biology 6, 920–922
(October 2004); doi:10.1038/ncb1004-920
| Full Text (HTML/PDF) |
letter
Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage
Jian Hu, Chad M. McCall, Tomohiko Ohta and Yue Xiong
Nature Cell Biology 6, 1003–1009
(October 2004); doi:10.1038/ncb1172
| First Paragraph | Full Text (HTML/PDF) |
review article
Liver regeneration: from myth to mechanism
Rebecca Taub
Nature Reviews Molecular Cell Biology 5, 836–847
(October 2004); doi:10.1038/nrm1489
| Abstract | Full Text (HTML / PDF) |
article
Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes
Elmar Jaeckel, Myra A Lipes and Harald von Boehmer
Nature Immunology 5, 1028–1035
(October 2004); doi:10.1038/ni1120
| Abstract | Full Text (HTML/PDF) |
review article
Toll-like receptor control of the adaptive immune responses
Akiko Iwasaki and Ruslan Medzhitov
Nature Immunology 5, 987–995
(October 2004); doi:10.1038/ni1112
| Abstract | Full Text (HTML/PDF) |
review article
Gene therapy for autoimmune diseases: quo vadis?
Yuti Chernajovsky, David J. Gould and Osvaldo L. Podhajcer
Nature Reviews Immunology 4, 800–811
(October 2004); doi:10.1038/nri1459
| Abstract | Full Text (HTML / PDF) |
article
Selective inactivation or reconstitution of adenosine A2A receptors in bone marrow cells reveals their significant contribution to the development of ischemic brain injury
Liqun Yu, Zhihong Huang, Juliana Mariani, Yumei Wang, Michael Moskowitz and Jiang-Fan Chen
Nature Medicine 10, 1081–1087
(October 2004); doi:10.1038/nm1103
| Abstract | Full Text (HTML/PDF) |
news and views
Bone marrow spawns brain killers
Costantino Iadecola
Nature Medicine 10, 1044–1045
(October 2004); doi:10.1038/nm1004-1044
| Full Text (HTML/PDF) |
brief communication
Nonsteroidal anti-inflammatory drugs lower Aβ42 and change presenilin 1 conformation
Alberto Lleó, Oksana Berezovska, Lauren Herl, Susan Raju, Amy Deng, Brian J Bacskai, Matthew P Frosch, Michael Irizarry and Bradley T Hyman
Nature Medicine 10, 1065–1066
(October 2004); doi:10.1038/nm1112
| First Paragraph | Full Text (HTML/PDF) |
review article
High interstitial fluid pressure — an obstacle in cancer therapy
Carl-Henrik Heldin, Kristofer Rubin, Kristian Pietras and Arne Östman
Nature Reviews Cancer 4, 806–813
(October 2004); doi:10.1038/nrc1456
| Abstract | Full Text (HTML / PDF) |
brief communication
Regulatory evolution across the protein interaction network
Bernardo Lemos, Colin D Meiklejohn and Daniel L Hartl
Nature Genetics 36, 1059–1060
(October 2004); doi:10.1038/ng1427
| First Paragraph | Full Text (HTML/PDF) |
news and views
Antisense inhibition of reward learning
Gregory D Horwitz and Edward M Callaway
Nature Neuroscience 7, 1023–1024
(October 2004); doi:10.1038/nn1004-1023
| Full Text (HTML/PDF) |
review article
Sexual differentiation of the vertebrate nervous system
John A Morris, Cynthia L Jordan and S Marc Breedlove
Nature Neuroscience 7, 1034–1039
(October 2004); doi:10.1038/nn1325
| Abstract | Full Text (HTML/PDF) |
review article
PDZ domain proteins of synapses
Eunjoon Kim and Morgan Sheng
Nature Reviews Neuroscience 5, 771–781
(October 2004); doi:10.1038/nrn1517
| Abstract | Full Text (HTML / PDF) |
letter
Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins
Ana-Maria Fernandez-Escamilla, Frederic Rousseau, Joost Schymkowitz and Luis Serrano
Nature Biotechnology 22, 1302–1306
(October 2004); doi:10.1038/nbt1012
| First Paragraph | Full Text (HTML/PDF) |
news and views
A universal TANGO?
Vijay S Pande
Nature Biotechnology 22, 1240–1241
(October 2004); doi:10.1038/nbt1004-1240
| Full Text (HTML/PDF) |
review article
Glycomics: a pathway to a class of new and improved therapeutics
Zachary Shriver, S. Raguram and Ram Sasisekharan
Nature Reviews Drug Discovery 3, 863–873
(October 2004); doi:10.1038/nrd1521
| Abstract | Full Text (HTML / PDF) |
article
Linkage between dynamics and catalysis in a thermophilic-mesophilic enzyme pair
Magnus Wolf-Watz, Vu Thai, Katherine Henzler-Wildman, Georgia Hadjipavlou, Elan Z Eisenmesser and Dorothee Kern
Nature Structural and Molecular Biology 11, 945–949
(October 2004); doi:10.1038/nsmb821
| Abstract | Full Text (HTML/PDF) |
news and views
Out of hot water
Mikael Akke
Nature Structural and Molecular Biology 11, 912–913
(October 2004); doi:10.1038/nsmb1004-912
| Full Text (HTML/PDF) |
article
Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo
Axel Nimmerjahn, Frank Kirchhoff, Jason N D Kerr and Fritjof Helmchen
Nature Methods 1, 31–37
(October 2004); doi:10.1038/nmeth706
| Abstract | Full Text (HTML/PDF) |
article
A custom microarray platform for analysis of microRNA gene expression
J Michael Thomson, Joel Parker, Charles M Perou and Scott M Hammond
Nature Methods 1, 47–53
(October 2004); doi:10.1038/nmeth704
| Abstract | Full Text (HTML/PDF) |
review article
Antimicrobial reactive oxygen and nitrogen species: concepts and controversies
Ferric C. Fang
Nature Reviews Microbiology 2, 820–832
(October 2004); doi:10.1038/nrmicro1004
| Abstract | Full Text (HTML/PDF) |
letters to nature
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
Keisuke Ito , Atsushi Hirao, Fumio Arai, Sahoko Matsuoka, Keiyo Takubo, Isao Hamaguchi, Kana Nomiyama, Kentaro Hosokawa, Kazuhiro Sakurada, Naomi Nakagata, Yasuo Ikeda, Tak W. Mak and Toshio Suda
Nature 431, 997–1002
(21 October 2004); doi:10.1038/nature02989
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells
Hanno Hock , Melanie J. Hamblen, Heather M. Rooke, Jeffrey W. Schindler, Shireen Saleque, Yuko Fujiwara and Stuart H. Orkin
Nature 431, 1002–1007
(21 October 2004); doi:10.1038/nature02994
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Essential role for the p110δ phosphoinositide 3-kinase in the allergic response
Khaled Ali, Antonio Bilancio, Matthew Thomas, Wayne Pearce, Alasdair M. Gilfillan, Christine Tkaczyk, Nicolas Kuehn, Alexander Gray, June Giddings, Emma Peskett, Roy Fox, Ian Bruce, Christoph Walker, Carol Sawyer, Klaus Okkenhaug, Peter Finan and Bart Vanhaesebroeck
Nature 431, 1007–1011
(21 October 2004); doi:10.1038/nature02991
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1
Grzegorz Ira, Achille Pellicioli, Alitukiriza Balijja, Xuan Wang, Simona Fiorani, Walter Carotenuto, Giordano Liberi, Debra Bressan, Lihong Wan, Nancy M. Hollingsworth, James E. Haber and Marco Foiani
Nature 431, 1011–1017
(21 October 2004); doi:10.1038/nature02964
| First Paragraph | Full Text (HTML / PDF) |
news and views
Cancer: Negative feedback for B cells
Louis M. Staudt
The discovery of a protein that regulates the production of antibody-generating B cells has implications for our understanding of how cancers of the immune system develop — and how they might be treated.
Nature 431, 919–920
(21 October 2004); doi:10.1038/431919a
| Full Text (HTML / PDF) |
article
Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial-mesenchymal transition
Binhua P. Zhou, Jiong Deng, Weiya Xia, Jihong Xu, Yan M. Li, Mehmet Gunduz and Mien-Chie Hung
Nature Cell Biology 6, 931–940
(October 2004); doi:10.1038/ncb1173
| Abstract | Full Text (HTML/PDF) |
news and views
GSK-3β sets Snail's pace
Karni Schlessinger and Alan Hall
Nature Cell Biology 6, 913–915
(October 2004); doi:10.1038/ncb1004-913
| Full Text (HTML/PDF) |
letter
Recruitment of Xenopus Scc2 and cohesin to chromatin requires the pre-replication complex
Tatsuro S. Takahashi, Pannyun Yiu, Michael F. Chou, Steven Gygi and Johannes C. Walter
Nature Cell Biology 6, 991–996
(October 2004); doi:10.1038/ncb1177
| First Paragraph | Full Text (HTML/PDF) |
review article
Checking on DNA damage in S phase
Jiri Bartek, Claudia Lukas and Jiri Lukas
Nature Reviews Molecular Cell Biology 5, 792–804
(October 2004); doi:10.1038/nrm1493
| Abstract | Full Text (HTML / PDF) |
article
Long-range intrachromosomal interactions in the T helper type 2 cytokine locus
Charalampos G Spilianakis and Richard A Flavell
Nature Immunology 5, 1017–1027
(October 2004); doi:10.1038/ni1115
| Abstract | Full Text (HTML/PDF) |
article
Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6
Taro Kawai, Shintaro Sato, Ken J Ishii, Cevayir Coban, Hiroaki Hemmi, Masahiro Yamamoto, Kenta Terai, Michiyuki Matsuda, Jun-ichiro Inoue, Satoshi Uematsu, Osamu Takeuchi and Shizuo Akira
Nature Immunology 5, 1061–1068
(October 2004); doi:10.1038/ni1118
| Abstract | Full Text (HTML/PDF) |
news and views
A polarizing situation
Tasha N Sims and Michael L Dustin
Nature Immunology 5, 1012–1013
(October 2004); doi:10.1038/ni1004-1012
| Full Text (HTML/PDF) |
review article
Interplay of natural killer cells and their receptors with the adaptive immune response
David H Raulet
Nature Immunology 5, 996–1002
(October 2004); doi:10.1038/ni1114
| Abstract | Full Text (HTML/PDF) |
review article
The multifaceted roles of TRAFs in the regulation of B-cell function
Gail A. Bishop
Nature Reviews Immunology 4, 775–786
(October 2004); doi:10.1038/nri1462
| Abstract | Full Text (HTML / PDF) |
review article
Immune responses to Listeria monocytogenes
Eric G. Pamer
Nature Reviews Immunology 4, 812–823
(October 2004); doi:10.1038/nri1461
| Abstract | Full Text (HTML / PDF) |
article
Aberrant cannabinoid signaling impairs oviductal transport of embryos
Haibin Wang, Yong Guo, Dingzhi Wang, Philip J Kingsley, Lawrence J Marnett, Sanjoy K Das, Raymond N DuBois and Sudhansu K Dey
Nature Medicine 10, 1074–1080
(October 2004); doi:10.1038/nm1104
| Abstract | Full Text (HTML/PDF) |
article
4-1BB-mediated immunotherapy of rheumatoid arthritis
Su K Seo, Jae H Choi, Young H Kim, Woo J Kang, Hye Y Park, Jae H Suh, Beom K Choi, Dass S Vinay and Byoung S Kwon
Nature Medicine 10, 1088–1094
(October 2004); doi:10.1038/nm1107
| Abstract | Full Text (HTML/PDF) |
news and views
Suppressing the self in rheumatoid arthritis
Robert S Mittler
Nature Medicine 10, 1047–1049
(October 2004); doi:10.1038/nm1004-1047
| Full Text (HTML/PDF) |
review article
Epstein-Barr virus: 40 years on
Lawrence S. Young and Alan B. Rickinson
Nature Reviews Cancer 4, 757–768
(October 2004); doi:10.1038/nrc1452
| Abstract | Full Text (HTML / PDF) |
letter
A specific requirement for PDGF-C in palate formation and PDGFR-α signaling
Hao Ding, Xiaoli Wu, Hans Boström, Injune Kim, Nicole Wong, Bonny Tsoi, Meredith O'Rourke, Gou Young Koh, Philippe Soriano, Christer Betsholtz, Thomas C Hart, Mary L Marazita, L L Field, Patrick P L Tam and Andras Nagy
Nature Genetics 36, 1111–1116
(October 2004); doi:10.1038/ng1415
| First Paragraph | Full Text (HTML/PDF) |
article
Rolling blackout, a newly identified PIP2-DAG pathway lipase required for Drosophila phototransduction
Fu-De Huang, Heinrich J G Matthies, Sean D Speese, Mark A Smith and Kendal Broadie
Nature Neuroscience 7, 1070–1078
(October 2004); doi:10.1038/nn1313
| Abstract | Full Text (HTML/PDF) |
review article
The neurobiology of pair bonding
Larry J Young and Zuoxin Wang
Nature Neuroscience 7, 1048–1054
(October 2004); doi:10.1038/nn1327
| Abstract | Full Text (HTML/PDF) |
review article
Ca2+-activated K+ channels: molecular determinants and function of the SK family
Martin Stocker
Nature Reviews Neuroscience 5, 758–770
(October 2004); doi:10.1038/nrn1516
| Abstract | Full Text (HTML / PDF) |
news and views
Engineering sweet targets for magic bullets
Ten Feizi
Nature Biotechnology 22, 1244–1245
(October 2004); doi:10.1038/nbt1004-1244
| Full Text (HTML/PDF) |
review article
Exploiting biological complexity for strain improvement through systems biology
Gregory Stephanopoulos, Hal Alper and Joel Moxley
Nature Biotechnology 22, 1261–1267
(October 2004); doi:10.1038/nbt1016
| Abstract | Full Text (HTML/PDF) |
review article
Bradykinin receptor ligands: therapeutic perspectives
François Marceau and Domenico Regoli
Nature Reviews Drug Discovery 3, 845–852
(October 2004); doi:10.1038/nrd1522
| Abstract | Full Text (HTML / PDF) |
article
A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8
Danny T Huang, David W Miller, Rose Mathew, Robert Cassell, James M Holton, Martine F Roussel and Brenda A Schulman
Nature Structural and Molecular Biology 11, 927–935
(October 2004); doi:10.1038/nsmb826
| Abstract | Full Text (HTML/PDF) |
news and views
Grabbing E2 by the tail
Andrew P VanDemark and Christopher P Hill
Nature Structural and Molecular Biology 11, 908–909
(October 2004); doi:10.1038/nsmb1004-908
| Full Text (HTML/PDF) |
brief communication
A rapid method for determining protein kinase phosphorylation specificity
Jessica E Hutti, Emily T Jarrell, James D Chang, Derek W Abbott, Peter Storz, Alex Toker, Lewis C Cantley and Benjamin E Turk
Nature Methods 1, 27–29
(October 2004); doi:10.1038/nmeth708
| Abstract | Full Text (HTML/PDF) |
news and views
Novel at the library
Michael B Yaffe
Nature Methods 1, 13–14
(October 2004); doi:10.1038/nmeth1004-13
| Full Text (HTML/PDF) |
article
Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition
Leonardo H Travassos, Stephen E Girardin, Dana J Philpott, Didier Blanot, Marie-Anne Nahori, Catherine Werts and Ivo G Boneca
EMBO Reports 5, 1000–1006
(October 2004); doi:10.1038/sj.embor.7400248
| Abstract | Full Text (HTML/PDF) |
article
Structure of a glutamate transporter homologue from Pyrococcus horikoshii
Dinesh Yernool, Olga Boudker, Yan Jin and Eric Gouaux
Nature 431, 811–818
(14 October 2004); doi:10.1038/nature03018
| Abstract | Full Text (HTML / PDF) |
news and views
Accessing a transporter structure
Michael P. Kavanaugh
Nature 431, 752–753
(14 October 2004); doi:10.1038/431752a
| Full Text (HTML / PDF) |
letters to nature
Hedgehog signalling controls eye degeneration in blind cavefish
Yoshiyuki Yamamoto, David W. Stock and William R. Jeffery
Nature 431, 844–847
(14 October 2004); doi:10.1038/nature02864
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
A relative signalling model for the formation of a topographic neural map
Michaël Reber, Patrick Burrola and Greg Lemke
Nature 431, 847–853
(14 October 2004); doi:10.1038/nature02957
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
A single population of olfactory sensory neurons mediates an innate avoidance behaviour in Drosophila
Greg S. B. Suh, Allan M. Wong, Anne C. Hergarden, Jing W. Wang, Anne F. Simon, Seymour Benzer, Richard Axel and David J. Anderson
Nature 431, 854–859
(14 October 2004); doi:10.1038/nature02980
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Role of histone H2A ubiquitination in Polycomb silencing
Hengbin Wang, Liangjun Wang, Hediye Erdjument-Bromage, Miguel Vidal, Paul Tempst, Richard S. Jones and Yi Zhang
Nature 431, 873–878
(14 October 2004); doi:10.1038/nature02985
| First Paragraph | Full Text (HTML / PDF) |
article
Identification of BRCA1-IRIS, a BRCA1 locus product
Wael M. ElShamy and David M. Livingston
Nature Cell Biology 6, 954–967
(October 2004); doi:10.1038/ncb1171
| Abstract | Full Text (HTML/PDF) |
news and views
Refocusing on BRCA1
Alan Ashworth
Nature Cell Biology 6, 916–917
(October 2004); doi:10.1038/ncb1004-916
| Full Text (HTML/PDF) |
letter
Hog1 mediates cell-cycle arrest in G1 phase by the dual targeting of Sic1
Xavier Escoté, Meritxell Zapater, Josep Clotet and Francesc Posas
Nature Cell Biology 6, 997–1002
(October 2004); doi:10.1038/ncb1174
| Abstract | Full Text (HTML/PDF) |
review article
Connecting proliferation and apoptosis in development and disease
David R. Hipfner and Stephen M. Cohen
Nature Reviews Molecular Cell Biology 5, 805–815
(October 2004); doi:10.1038/nrm1491
| Abstract | Full Text (HTML / PDF) |
review article
Molecular mechanisms of translational control
Fátima Gebauer and Matthias W. Hentze
Nature Reviews Molecular Cell Biology 5, 827–835
(October 2004); doi:10.1038/nrm1488
| Abstract | Full Text (HTML / PDF) |
article
Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription
Holly Maier, Rachel Ostraat, Hua Gao, Scott Fields, Susan A Shinton, Kay L Medina, Tomokatsu Ikawa, Cornelis Murre, Harinder Singh, Richard R Hardy and James Hagman
Nature Immunology 5, 1069–1077
(October 2004); doi:10.1038/ni1119
| Abstract | Full Text (HTML/PDF) |
article
CD22 regulates B lymphocyte function in vivo through both ligand-dependent and ligand-independent mechanisms
Jonathan C Poe, Yoko Fujimoto, Minoru Hasegawa, Karen M Haas, Ann S Miller, Isaac G Sanford, Cheryl B Bock, Manabu Fujimoto and Thomas F Tedder
Nature Immunology 5, 1078–1087
(October 2004); doi:10.1038/ni1121
| Abstract | Full Text (HTML/PDF) |
news and views
Unmasking connections in transmembrane immune signaling
Jamey D Marth
Nature Immunology 5, 1008–1010
(October 2004); doi:10.1038/ni1004-1008
| Full Text (HTML/PDF) |
review article
The complement system in regulation of adaptive immunity
Michael C Carroll
Nature Immunology 5, 981–986
(October 2004); doi:10.1038/ni1113
| Abstract | Full Text (HTML/PDF) |
review article
Mast-cell responses to pathogens
Jean S. Marshall
Nature Reviews Immunology 4, 787–799
(October 2004); doi:10.1038/nri1460
| Abstract | Full Text (HTML / PDF) |
letter
Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide
Hideaki Kaneto, Yoshihisa Nakatani, Takeshi Miyatsuka, Dan Kawamori, Taka-aki Matsuoka, Munehide Matsuhisa, Yoshitaka Kajimoto, Hidenori Ichijo, Yoshimitsu Yamasaki and Masatsugu Hori
Nature Medicine 10, 1128–1132
(October 2004); doi:10.1038/nm1111
| First Paragraph | Full Text (HTML/PDF) |
news and views
Hematopoietic stem cells get closer to the bone
Connie Eaves
Nature Medicine 10, 1042–1044
(October 2004); doi:10.1038/nm1004-1042
| Full Text (HTML/PDF) |
review article
Polyamines and cancer: old molecules, new understanding
Eugene W. Gerner and Frank L. Meyskens Jr
Nature Reviews Cancer 4, 781–792
(January 2004); doi:10.1038/nrc1454
| Abstract | Full Text (HTML / PDF) |
letter
Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia
C. Graux, J. Cools, C. Melotte, H. Quentmeier, A. Ferrando, R. Levine, J.R. Vermeesch, M. Stul, B. Dutta, N. Boeckx, A. Bosly, P. Heimann, A. Uyttebroeck, N. Mentens, R. Somers, R.A.F. MacLeod, H.G. Drexler, A.T. Look, D.G. Gilliland, L. Michaux, P. Vandenberghe, I. Wlodarska, Peter Marynen and Anne Hagemeijer
Nature Genetics 36, 1084–1089
(October 2004); doi:10.1038/ng1425
| First Paragraph | Full Text (HTML/PDF) |
review article
Genetic predisposition to cancer — insights from population genetics
Steven A. Frank
Nature Reviews Genetics 5, 764–772
(October 2004); doi:10.1038/nrg1450
| Abstract | Full Text (HTML / PDF) |
article
Mechanism of extrasynaptic dopamine signaling in Caenorhabditis elegans
Daniel L Chase, Judy S Pepper and Michael R Koelle
Nature Neuroscience 7, 1096–1103
(October 2004); doi:10.1038/nn1316
| Abstract | Full Text (HTML/PDF) |
news and views
Dopamine: should I stay or should I go now?
Erik M Jorgensen
Nature Neuroscience 7, 1019–1021
(October 2004); doi:10.1038/nn1004-1019
| Full Text (HTML/PDF) |
review article
The neural basis of puberty and adolescence
Cheryl L Sisk and Douglas L Foster
Nature Neuroscience 7, 1040–1047
(October 2004); doi:10.1038/nn1326
| Abstract | Full Text (HTML/PDF) |
perspectives
Opinion: Mechanisms of roof plate formation in the vertebrate CNS
Victor V. Chizhikov and Kathleen J. Millen
Nature Reviews Neuroscience 5, 808–812
(October 2004); doi:10.1038/nrn1520
| Abstract | Full Text (HTML / PDF) |
article
The site-specific incorporation of p-iodo-L-phenylalanine into proteins for structure determination
Jianming Xie, Lei Wang, Ning Wu, Ansgar Brock, Glen Spraggon and Peter G Schultz
Nature Biotechnology 22, 1297–1301
(October 2004); doi:10.1038/nbt1013
| First Paragraph | Full Text (HTML/PDF) |
news and views
Phasing in iodine for structure determination
Zbigniew Dauter
Nature Biotechnology 22, 1239–1240
(October 2004); doi:10.1038/nbt1004-1239
| Full Text (HTML/PDF) |
article
A phenylalanine zipper mediates APS dimerization
Sirano Dhe-Paganon, Eric D Werner, Masahiro Nishi, Lone Hansen, Young-In Chi and Steven E Shoelson
Nature Structural and Molecular Biology 11, 968–974
(October 2004); doi:10.1038/nsmb829
| Abstract | Full Text (HTML/PDF) |
article
The RanBP2 SUMO E3 ligase is neither HECT- nor RING-type
Andrea Pichler, Puck Knipscheer, Hisato Saitoh, Titia K Sixma and Frauke Melchior
Nature Structural and Molecular Biology 11, 984–991
(October 2004); doi:10.1038/nsmb834
| Abstract | Full Text (HTML/PDF) |
news and views
Arginine methylation signals mRNA export
Kiven E Lukong and Stéphane Richard
Nature Structural and Molecular Biology 11, 914–915
(October 2004); doi:10.1038/nsmb1004-914
| Full Text (HTML/PDF) |
article
Automated approach for quantitative analysis of complex peptide mixtures from tandem mass spectra
John D Venable, Meng-Qiu Dong, James Wohlschlegel, Andrew Dillin and John R Yates III
Nature Methods 1, 39–45
(October 2004); doi:10.1038/nmeth705
| Abstract | Full Text (HTML/PDF) |
news and views
Shotgun mass spec goes independent
Daniel C Liebler
Nature Methods 1, 16–17
(October 2004); doi:10.1038/nmeth1004-16
| Abstract | Full Text (HTML/PDF) |
review article
Chlamydia and apoptosis: life and death decisions of an intracellular pathogen
Gerald I. Byrne and David M. Ojcius
Nature Reviews Microbiology 2, 802–808
(October 2004); doi:10.1038/nrmicro1007
| Abstract | Full Text (HTML/PDF) |
article
Surface mechanics mediate pattern formation in the developing retina
Takashi Hayashi and Richard W. Carthew
Nature 431, 647–652
(07 October 2004); doi:10.1038/nature02952
| Abstract | Full Text (HTML / PDF) |
news and views
Developmental biology: Holding it together in the eye
Paul A. Janmey and Dennis E Discher
Nature 431, 635–636
(07 October 2004); doi:10.1038/431635a
| Full Text (HTML / PDF) |
article
Direct integration of Hox and segmentation gene inputs during Drosophila development
Brian Gebelein, Daniel J. McKay and Richard S. Mann
Nature 431, 653–659
(07 October 2004); doi:10.1038/nature02946
| Abstract | Full Text (HTML / PDF) |
letters to nature
Migratory neural crest-like cells form body pigmentation in a urochordate embryo
William R. Jeffery, Allen G. Strickler and Yoshiyuki Yamamoto
Nature 431, 696–699
(07 October 2004); doi:10.1038/nature02975
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letters to nature
Hedgehog signalling in prostate regeneration, neoplasia and metastasis
Sunil S. Karhadkar, G. Steven Bova , Nadia Abdallah, Surajit Dhara, Dale Gardner, Anirban Maitra, John T. Isaacs, David M. Berman and Philip A. Beachy
Nature 431, 707–712
(07 October 2004); doi:10.1038/nature02962
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letters to nature
p19ARF directly and differentially controls the functions of c-Myc independently of p53
Ying Qi, Mark A. Gregory, Zhaoliang Li, Jeffrey P. Brousal, Kimberly West and Stephen R. Hann
Nature 431, 712–717
(07 October 2004); doi:10.1038/nature02958
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news and views
Molecular biology: No exception to reversibility
Yi Zhang
Nature 431, 637–639
(07 October 2004); doi:10.1038/431637a
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news and views
Cell biology: Light on pits
Elizabeth Smythe
Nature 431, 641–642
(07 October 2004); doi:10.1038/431641a
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article
Syntabulin is a microtubule-associated protein implicated in syntaxin transport in neurons
Qingning Su, Qian Cai, Claudia Gerwin, Carolyn L. Smith and Zu-Hang Sheng
Nature Cell Biology 6, 941–953
(October 2004); doi:10.1038/ncb1169
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news and views
Hauling t-SNAREs on the microtubule highway
R. Grace Zhai and Hugo J. Bellen
Nature Cell Biology 6, 918–919
(October 2004); doi:10.1038/ncb1004-918
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article
A new effector pathway links ATM kinase with the DNA damage response
Constantinos Demonacos, Marija Krstic-Demonacos, Linda Smith, Danmei Xu, Darran P. O'Connor, Martin Jansson and Nicholas B. La Thangue
Nature Cell Biology 6, 968–976
(October 2004); doi:10.1038/ncb1170
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review article
Pathways of chaperone-mediated protein folding in the cytosol
Jason C. Young, Vishwas R. Agashe, Katja Siegers and F. Ulrich Hartl
Nature Reviews Molecular Cell Biology 5, 781–791
(October 2004); doi:10.1038/nrm1492
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perspectives
Innovation: Imaging gene expression in single living cells
Yaron Shav-Tal, Robert H. Singer and Xavier Darzacq
Nature Reviews Molecular Cell Biology 5, 855–862
(October 2004); doi:10.1038/nrm1494
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article
GA binding protein regulates interleukin 7 receptor α-chain gene expression in T cells
Hai-Hui Xue, Julie Bollenbacher, Valentina Rovella, Radhika Tripuraneni, Yu-Bin Du, Cheng-Yu Liu, Ann Williams, J Philip McCoy and Warren J Leonard
Nature Immunology 5, 1036–1044
(October 2004); doi:10.1038/ni1117
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article
The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses
David L Boone, Emre E Turer, Eric G Lee, Regina-Celeste Ahmad, Matthew T Wheeler, Colleen Tsui, Paula Hurley, Marcia Chien, Sophia Chai, Osamu Hitotsumatsu, Elizabeth McNally, Cecile Pickart and Averil Ma
Nature Immunology 5, 1052–1060
(October 2004); doi:10.1038/ni1110
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news and views
DUBbing down innate immunity
Neal Silverman and Katherine Fitzgerald
Nature Immunology 5, 1010–1012
(October 2004); doi:10.1038/ni1004-1010
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review article
A stepwise epigenetic process controls immunoglobulin allelic exclusion
Yehudit Bergman and Howard Cedar
Nature Reviews Immunology 4, 753–761
(October 2004); doi:10.1038/nri1458
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article
Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway
Reiko Hanada, Hitoshi Teranishi, James Todd Pearson, Mamoru Kurokawa, Hiroshi Hosoda, Nobuhiro Fukushima, Yoshihiko Fukue, Ryota Serino, Hiroaki Fujihara, Yoichi Ueta, Masahito Ikawa, Masaru Okabe, Noboru Murakami, Mikiyasu Shirai, Hironobu Yoshimatsu, Kenji Kangawa and Masayasu Kojima
Nature Medicine 10, 1067–1073
(October 2004); doi:10.1038/nm1106
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technical report
Volumetric computed tomography (VCT): a new technology for noninvasive, high-resolution monitoring of tumor angiogenesis
Fabian Kiessling, Susanne Greschus, Matthias P Lichy, Michael Bock, Christian Fink, Silvia Vosseler, Jens Moll, Margareta M Mueller, Norbert E. Fusenig, Horst Traupe and Wolfhard Semmler
Nature Medicine 10, 1133–1138
(October 2004); doi:10.1038/nm1101
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news and views
Nutrient sensor links obesity with diabetes risk
Mary-Elizabeth Patti and Barbara B Kahn
Nature Medicine 10, 1049–1050
(October 2004); doi:10.1038/nm1004-1049
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review article
Genetic predisposition to colorectal cancer
Albert de la Chapelle
Nature Reviews Cancer 4, 769–780
(October 2004); doi:10.1038/nrc1453
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review article
Post-translational modification of p53 in tumorigenesis
Ann M. Bode and Zigang Dong
Nature Reviews Cancer 4, 793–805
(October 2004); doi:10.1038/nrc1455
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letter
A module map showing conditional activity of expression modules in cancer
Eran Segal, Nir Friedman, Daphne Koller and Aviv Regev
Nature Genetics 36, 1090–1098
(October 2004); doi:10.1038/ng1434
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article
Rapid and persistent modulation of actin dynamics regulates postsynaptic reorganization underlying bidirectional plasticity
Ken-Ichi Okamoto, Takeharu Nagai, Atsushi Miyawaki and Yasunori Hayashi
Nature Neuroscience 7, 1104–1112
(October 2004); doi:10.1038/nn1311
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review article
Interneurons of the neocortical inhibitory system
Henry Markram, Maria Toledo-Rodriguez, Yun Wang, Anirudh Gupta, Gilad Silberberg and Caizhi Wu
Nature Reviews Neuroscience 5, 793–807
(October 2004); doi:10.1038/nrn1519
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review article
Targeting of host-cell ubiquitin-like pathways by bacterial factors
Laurent Boyer and Emmanuel Lemichez
Nature Reviews Microbiology 2, 779–788
(October 2004); doi:10.1038/nrmicro1005
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research article
Protein sequencing by mass analysis of polypeptide ladders after controlled protein hydrolysis
Hongying Zhong, Ying Zhang, Zhihui Wen and Liang Li
Nature Biotechnology 22, 1291–1296
(October 2004); doi:10.1038/nbt1011
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news and views
Climbing the protein ladder
Norman J Dovichi
Nature Biotechnology 22, 1242–1243
(October 2004); doi:10.1038/nbt1004-1242
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historical perspective
The evolution of molecular biology into systems biology
Hans V Westerhoff and Bernhard O Palsson
Nature Biotechnology 22, 1249–1252
(October 2004); doi:10.1038/nbt1020
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article
Identification of the versatile scaffold protein RACK1 on the eukaryotic ribosome by cryo-EM
Jayati Sengupta, Jakob Nilsson, Richard Gursky, Christian M T Spahn, Poul Nissen and Joachim Frank
Nature Structural and Molecular Biology 11, 957–962
(October 2004); doi:10.1038/nsmb822
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article
Structural basis of Rab5-Rabaptin5 interaction in endocytosis
Guangyu Zhu, Peng Zhai, Jian Liu, Simon Terzyan, Guangpu Li and Xuejun C Zhang
Nature Structural and Molecular Biology 11, 975–983
(October 2004); doi:10.1038/nsmb832
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article
In vitro selection and prediction of TIP47 protein-interaction interfaces
Alondra Schweizer Burguete, Pehr B Harbury and Suzanne R Pfeffer
Nature Methods 1, 55–60
(October 2004); doi:10.1038/nmeth702
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article
Exploiting the 21st amino acid — purifying and labeling proteins by selenolate targeting
Linda Johansson, Chunying Chen, Jan-Olov Thorell, Anna Fredriksson, Sharon Stone-Elander, Guro Gafvelin & Elias S J Arnér1
Nature Methods 1, 61–66
(October 2004); doi:10.1038/nmeth707
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article
A role for the immunological synapse in lineage commitment of CD4 lymphocytes
Roberto A. Maldonado, Darrell J. Irvine, Robert Schreiber and Laurie H. Glimcher
Nature 431, 527–532
(30 September 2004); doi:10.1038/nature02916
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letters to nature
A transmembrane protein required for acetylcholine receptor clustering in Caenorhabditis elegans
Christelle Gally, Stefan Eimer, Janet E. Richmond and Jean-Louis Bessereau
Nature 431, 578–582
(30 September 2004); doi:10.1038/nature02893
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brief communication
Lung cancer: Intragenic ERBB2 kinase mutations in tumours
Philip Stephens, Chris Hunter, Graham Bignell, Sarah Edkins, Helen Davies, Jon Teague, Claire Stevens, Sarah O'Meara, Raffaella Smith, Adrian Parker, Andy Barthorpe, Matthew Blow, Lisa Brackenbury, Adam Butler, Oliver Clarke, Jennifer Cole, Ed Dicks, Angus Dike, Anja Drozd, Ken Edwards, Simon Forbes, Rebecca Foster, Kristian Gray, Chris Greenman, Kelly Halliday, Katy Hills, Vivienne Kosmidou, Richard Lugg, Andy Menzies, Janet Perry, Robert Petty, Keiran Raine, Lewis Ratford, Rebecca Shepherd, Alexandra Small, Yvonne Stephens, Calli Tofts, Jennifer Varian, Sofie West, Sara Widaa, Andrew Yates, Francis Brasseur, Colin S. Cooper, Adrienne M. Flanagan, Margaret Knowles, Suet Y. Leung, David N. Louis, Leendert H. J. Looijenga, Bruce Malkowicz, Marco A. Pierotti, Bin Teh, Georgia Chenevix-Trench, Barbara L. Weber, Siu T. Yuen, Grace Harris, Peter Goldstraw, Andrew G. Nicholson, P. Andrew Futreal, Richard Wooster and Michael R. Stratton
Nature 431, 525–526
(30 September 2004); doi:10.1038/431525b
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technology feature
RNA interference: The silent treatment
Julie Clayton
Nature 431, 599–605
(30 September 2004); doi:10.1038/431599a
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letter
Calpain-mediated proteolysis of talin regulates adhesion dynamics
Santos J. Franco, Mary A. Rodgers, Benjamin J. Perrin, Jaewon Han, David A. Bennin, David R. Critchley and Anna Huttenlocher
Nature Cell Biology 6, 977–983
(October 2004); doi:10.1038/ncb1175
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news and views
Crossing the tracks
Jon Reynolds
Nature Cell Biology 6, 915
(October 2004); doi:10.1038/ncb1004-915
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review article
Integrin signalling during tumour progression
Wenjun Guo and Filippo G. Giancotti
Nature Reviews Molecular Cell Biology 5, 816–826
(October 2004); doi:10.1038/nrm1490
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article
Crucial functions of the Rap1 effector molecule RAPL in lymphocyte and dendritic cell trafficking
Koko Katagiri, Noriko Ohnishi, Kenji Kabashima, Tomonori Iyoda, Naoki Takeda, Yoichi Shinkai, Kayo Inaba and Tatsuo Kinashi
Nature Immunology 5, 1045–1051
(October 2004); doi:10.1038/ni1111
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news and views
RAPL: taking the Rap in immunity
Leo S Price and Johannes L Bos
Nature Immunology 5, 1007–1008
(October 2004); doi:10.1038/ni1004-1007
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review article
Ido expression by dendritic cells: tolerance and tryptophan catabolism
Andrew L. Mellor and David H. Munn
Nature Reviews Immunology 4, 762–774
(October 2004); doi:10.1038/nri1457
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article
Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung
Chun Geun Lee, Holger Link, Peter Baluk, Robert J Homer, Svetlana Chapoval, Vineet Bhandari, Min Jong Kang, Lauren Cohn, Yoon Keun Kim, Donald M McDonald and Jack A Elias
Nature Medicine 10, 1095–1103
(October 2004); doi:10.1038/nm1105
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news and views
VEGF obstructs the lungs
Marc E Rothenberg
Nature Medicine 10, 1041–1042
(October 2004); doi:10.1038/nm1004-1041
| Full Text (HTML/PDF) |
brief communication
Nonsteroidal anti-inflammatory drugs lower Aβ42 and change presenilin 1 conformation
Alberto Lleó, Oksana Berezovska, Lauren Herl, Susan Raju, Amy Deng, Brian J Bacskai, Matthew P Frosch, Michael Irizarry and Bradley T Hyman
Nature Medicine 10, 1065–1066
(October 2004); doi:10.1038/nm1112
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perspectives
Opinion: Hallmarks of 'BRCAness' in sporadic cancers
Nicholas Turner, Andrew Tutt and Alan Ashworth
Nature Reviews Cancer 4, 814–819
(October 2004); doi:10.1038/nrc1457
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letter
BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-β-catenin signaling
Xi C He, Jiwang Zhang, Wei-Gang Tong, Ossama Tawfik, Jason Ross, David H Scoville, Qiang Tian, Xin Zeng, Xi He, Leanne M Wiedemann, Yuji Mishina and Linheng Li
Nature Genetics 36, 1117–1121
(October 2004); doi:10.1038/ng1430
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news and views
Linking pathways in colorectal cancer
Gijs R van den Brink
Nature Genetics 36, 1038–1039
(October 2004); doi:10.1038/ng1004-1038
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review article
Genetic predisposition to cancer — insights from population genetics
Steven A. Frank
Nature Reviews Genetics 5, 764–772
(October 2004); doi:10.1038/nrg1450
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article
Control of axonal branching and synapse formation by focal adhesion kinase
Beatriz Rico, Hilary E Beggs, Dorreyah Schahin-Reed, Nikole Kimes, Andrea Schmidt and Louis F Reichardt
Nature Neuroscience 7, 1059–1069
(October 2004); doi:10.1038/nn1317
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article
Essential role of Ca2+-binding protein 4, a Cav1.4 channel regulator, in photoreceptor synaptic function
Françoise Haeseleer, Yoshikazu Imanishi, Tadao Maeda, Daniel E Possin, Akiko Maeda, Amy Lee, Fred Rieke and Krzysztof Palczewski
Nature Neuroscience 7, 1079–1087
(October 2004); doi:10.1038/nn1320
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review article
PDZ domain proteins of synapses
Eunjoon Kim and Morgan Sheng
Nature Reviews Neuroscience 5, 771–781
(October 2004); doi:10.1038/nrn1517
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article
Control of human potassium channel inactivation by editing of a small mRNA hairpin
Tarun Bhalla, Joshua J C Rosenthal, Miguel Holmgren and Robert Reenan
Nature Structural and Molecular Biology 11, 950–956
(October 2004); doi:10.1038/nsmb825
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news and views
RNA editing of a human potassium channel modifies its inactivation
Francisco Bezanilla
Nature Structural and Molecular Biology 11, 915–916
(October 2004); doi:10.1038/nsmb1004-915
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review article
New drugs for asthma
Peter J. Barnes
Nature Reviews Drug Discovery 3, 831–844
(October 2004); doi:10.1038/nrd1524
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