The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.
Click here for free access to the 'Featured Articles' section, with new articles every week.
article Thymosin β4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair
Ildiko Bock-Marquette , Ankur Saxena , Michael D. White, J. Michael DiMaio and Deepak Srivastava Nature432, 466–472
(25 November 2004); doi:10.1038/nature03000
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news and views Regenerative medicine: Prometheus unbound
Michael D. Schneider Nature432, 451–453
(25 November 2004); doi:10.1038/432451a
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letters to nature Mast cells promote homeostasis by limiting endothelin-1-induced toxicity
Marcus Maurer , Jochen Wedemeyer , Martin Metz , Adrian M. Piliponsky, Karsten Weller, Devavani Chatterjea, David E. Clouthier, Masashi M. Yanagisawa , Mindy Tsai and Stephen J. Galli Nature432, 512–516
(25 November 2004); doi:10.1038/nature03085
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letters to nature The yeast Rat1 exonuclease promotes transcription termination by RNA polymerase II
Minkyu Kim, Nevan J. Krogan, Lidia Vasiljeva, Oliver J. Rando, Eduard Nedea, Jack F. Greenblatt and Stephen Buratowski Nature432, 517–522
(25 November 2004); doi:10.1038/nature03041
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letters to nature Human 5′ → 3′ exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites
Steven West, Natalia Gromak and Nick J. Proudfoot Nature432, 522–525
(25 November 2004); doi:10.1038/nature03035
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letters to nature Autocatalytic RNA cleavage in the human β-globin pre-mRNA promotes transcription termination
Alexandre Teixeira, Abdessamad Tahiri-Alaoui, Steve West, Benjamin Thomas, Aroul Ramadass, Igor Martianov, Mick Dye, William James, Nick J. Proudfoot and Alexandre Akoulitchev Nature432, 526–530
(25 November 2004); doi:10.1038/nature03032
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news and views Molecular biology: Termination by torpedo
David Tollervey Nature432, 456–457
(25 November 2004); doi:10.1038/432456a
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letter Two anterograde intraflagellar transport motors cooperate to build sensory cilia on C. elegans neurons
Joshua J. Snow, Guangshuo Ou, Amy L. Gunnarson, M. Regina S. Walker, H. Mimi Zhou, Ingrid Brust-Mascher and Jonathan M. Scholey Nature Cell Biology6, 1109–1113
(November 2004); doi:10.1038/ncb1186
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letter A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1
Chikashi Obuse, Osamu Iwasaki, Tomomi Kiyomitsu, Gohta Goshima, Yusuke Toyoda and Mitsuhiro Yanagida Nature Cell Biology6, 1135–1141
(November 2004); doi:10.1038/ncb1187
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review article Subversion of phosphoinositide metabolism by intracellular bacterial pathogens
Javier Pizarro-Cerdá and Pascale Cossart Nature Cell Biology6, 1026–1033
(November 2004); doi:10.1038/ncb1104-1026
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review article Cell biology of protein misfolding: The examples of Alzheimer's and Parkinson's diseases
Dennis J. Selkoe Nature Cell Biology6, 1054–1061
(November 2004); doi:10.1038/ncb1104-1054
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review article Targeting Rab GTPases to distinct membrane compartments
Suzanne Pfeffer and Dikran Aivazian Nature Reviews Molecular Cell Biology5, 886–896
(November 2004); doi:10.1038/nrm1500
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article Amplification of IFN-α-induced STAT1 activation and inflammatory function by Syk and ITAM-containing adaptors
Ioannis Tassiulas, Xiaoyu Hu, Hao Ho, Yogita Kashyap, Paul Paik, Yongmei Hu, Clifford A Lowell and Lionel B Ivashkiv Nature Immunology5, 1181–1189
(November 2004); doi:10.1038/ni1126
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news and views Are dendritic cells end cells?
Ken Shortman and Li Wu Nature Immunology5, 1105–1106
(November 2004); doi:10.1038/ni1104-1105
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review article Intrinsic immunity: a front-line defense against viral attack
Paul D Bieniasz Nature Immunology5, 1109–1115
(November 2004); doi:10.1038/ni1125
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review article Forkhead-box transcription factors and their role in the immune system
Paul J. Coffer and Boudewijn M. T. Burgering Nature Reviews Immunology4, 889–899
(November 2004); doi:10.1038/nri1488
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article Enhanced insulin sensitivity, energy expenditure and thermogenesis in adipose-specific Pten suppression in mice
Nobuyasu Komazawa, Morihiro Matsuda, Gen Kondoh, Wataru Mizunoya, Masanori Iwaki, Toshiyuki Takagi, Yasuyuki Sumikawa, Kazuo Inoue, Akira Suzuki, Tak Wah Mak, Toru Nakano, Tohru Fushiki, Junji Takeda and Iichiro Shimomura Nature Medicine10, 1208–1215
(November 2004); doi:10.1038/nm1117
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news and views Turning up the heat in the fat cell
Domenico Accili and Luca Valenti Nature Medicine10, 1168–1169
(November 2004); doi:10.1038/nm1104-1168
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letter Cardiomyocyte-restricted peroxisome proliferator-activated receptor-δ deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy
Lihong Cheng, Guoliang Ding, Qianhong Qin, Yao Huang, William Lewis, Nu He, Ronald M Evans, Michael D Schneider, Florence A Brako, Yan Xiao, Yuqing E Chen and Qinglin Yang Nature Medicine10, 1245–1250
(November 2004); doi:10.1038/nm1116
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news and views Transporter of a malaria catastrophe
Thomas E Wellems Nature Medicine10, 1169–1171
(November 2004); doi:10.1038/nm1104-1169
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news and views From plankton to pathogen recognition
Robert L Modlin and Genhong Cheng Nature Medicine10, 1173–1174
(November 2004); doi:10.1038/nm1104-1173
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review article Why do cancers have high aerobic glycolysis?
Robert A. Gatenby and Robert J. Gillies Nature Reviews Cancer4, 891–899
(November 2004); doi:10.1038/nrc1478
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article Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway
Simon D Bamforth, José Bragança, Cassandra R Farthing, Jürgen E Schneider, Carol Broadbent, Anna C Michell, Kieran Clarke, Stefan Neubauer, Dominic Norris, Nigel A Brown, Robert H Anderson and Shoumo Bhattacharya Nature Genetics36, 1189–1196
(November 2004); doi:10.1038/ng1446
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article Par6α signaling controls glial-guided neuronal migration
David J Solecki, Lynn Model, Jedidiah Gaetz, Tarun M Kapoor and Mary E Hatten Nature Neuroscience7, 1195–1203
(November 2004); doi:10.1038/nn1332
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news and views Nucleokinesis illuminated
Benjamin Adam Samuels and Li-Huei Tsai Nature Neuroscience7, 1169–1170
(November 2004); doi:10.1038/nn1104-1169
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letter Engineered T-cell receptor tetramers bind MHC-peptide complexes with high affinity
Ramu A Subbramanian, Chikaya Moriya, Kristi L Martin, Fred W Peyerl, Atsuhiko Hasegawa, Akira Naoi, Heng Chhay, Patrick Autissier, Darci A Gorgone, Michelle A Lifton, Kristine Kuus-Reichel, Jörn E Schmitz, Norman L Letvin and Marcelo J Kuroda Nature Biotechnology22, 1429–1434
(December 2004); doi:10.1038/nbt1024
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review article Principles for modulation of the nuclear receptor superfamily
Hinrich Gronemeyer, Jan-Åke Gustafsson and Vincent Laudet Nature Reviews Drug Discovery3, 950–964
(November 2004); doi:10.1038/nrd1551
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article Intragenic DNA methylation alters chromatin structure and elongation efficiency in mammalian cells
Matthew C Lorincz, David R Dickerson, Mike Schmitt and Mark Groudine Nature Structural and Molecular Biology11, 1068–1075
(November 2004); doi:10.1038/nsmb840
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article PML bodies control the nuclear dynamics and function of the CHFR mitotic checkpoint protein
Matthew J Daniels, Alexander Marson and Ashok R Venkitaraman Nature Structural and Molecular Biology11, 1114–1121
(November 2004); doi:10.1038/nsmb837
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article RNAi living-cell microarrays for loss-of-function screens in Drosophila melanogaster cells
Douglas B Wheeler, Steve N Bailey, David A Guertin, Anne E Carpenter, Caitlin O Higgins and David M Sabatini Nature Methods1, 127–132
(November 2004); doi:10.1038/nmeth711
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news and views 5,000 RNAi experiments on a chip
Ben Lehner and Andrew G Fraser Nature Methods1, 103–104
(November 2004); doi:10.1038/nmeth1104-103
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meeting report ZOMES III: the interface between signalling and proteolysis
Eric C. Chang and Claus Schwechheimer EMBO reports5, 1041–1045
(November 2004); doi:10.1038/sj.embor.7400275
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article Regulation of p53 activity through lysine methylation
Sergei Chuikov, Julia K. Kurash, Jonathan R. Wilson, Bing Xiao, Neil Justin, Gleb S. Ivanov, Kristine McKinney, Paul Tempst, Carol Prives, Steven J. Gamblin, Nickolai A. Barlev and Danny Reinberg Nature432, 353–360
(18 November 2004); doi:10.1038/nature03117
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letters to nature A FADD-dependent innate immune mechanism in mammalian cells
Siddharth Balachandran, Emmanuel Thomas and Glen N. Barber Nature432, 401–405
(18 November 2004); doi:10.1038/nature03124
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letters to nature Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks
Yentram Huyen, Omar Zgheib, Richard A. DiTullio Jr, Vassilis G. Gorgoulis, Panayotis Zacharatos, Tom J. Petty, Emily A. Sheston, Hestia S. Mellert, Elena S. Stavridi and Thanos D. Halazonetis Nature432, 406–411
(18 November 2004); doi:10.1038/nature03114
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news and views Structural biology: Ion pump in the movies
C. Roy D. Lancaster Nature432, 286–287
(18 November 2004); doi:10.1038/432286a
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article Actin is part of pre-initiation complexes and is necessary for transcription by RNA polymerase II
Wilma A. Hofmann, Ljuba Stojiljkovic, Beata Fuchsova, Gabriela M. Vargas, Evangelos Mavrommatis, Vlada Philimonenko, Katarina Kysela, James A. Goodrich, James L. Lessard, Thomas J. Hope, Pavel Hozak and Primal de Lanerolle Nature Cell Biology6, 1094–1101
(November 2004); doi:10.1038/ncb1182
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news and views Actin's many actions start at the genes
Werner W. Franke Nature Cell Biology6, 1013–1014
(November 2004); doi:10.1038/ncb1104-1013
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letter Mapping the dynamic organization of the nuclear pore complex inside single living cells
Gwénaël Rabut, Valérie Doye and Jan Ellenberg Nature Cell Biology6, 1114–1121
(November 2004); doi:10.1038/ncb1184
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review article The many faces of filamin: A versatile molecular scaffold for cell motility and signalling
Yuanyi Feng and Christopher A. Walsh Nature Cell Biology6, 1034–1038
(November 2004); doi:10.1038/ncb1104-1034
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review article Molecular mechanisms of caspase regulation during apoptosis
Stefan J. Riedl and Yigong Shi Nature Reviews Molecular Cell Biology5, 897–907
(November 2004); doi:10.1038/nrm1496
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article Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells
Minghui Zhang, Hua Tang, Zhenhong Guo, Huazhang An, Xuejun Zhu, Wengang Song, Jun Guo, Xin Huang, Taoyong Chen, Jianli Wang and Xuetao Cao Nature Immunology5, 1124–1133
(November 2004); doi:10.1038/ni1130
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article Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island
Jérôme Viala, Catherine Chaput, Ivo G Boneca, Ana Cardona, Stephen E Girardin, Anthony P Moran, Rafika Athman, Sylvie Mémet, Michel R Huerre, Anthony J Coyle, Peter S DiStefano, Philippe J Sansonetti, Agnès Labigne, John Bertin, Dana J Philpott and Richard L Ferrero Nature Immunology5, 1166–1174
(November 2004); doi:10.1038/ni1131
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news and views Inside sensors detecting outside pathogens
Ennio De Gregorio and Rino Rappuoli Nature Immunology5, 1099–1100
(November 2004); doi:10.1038/ni1104-1099
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review article Retroviral restriction by APOBEC proteins
Reuben S. Harris and Mark T. Liddament Nature Reviews Immunology4, 868–877
(November 2004); doi:10.1038/nri1489
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review article Clinical strategies for expansion of haematopoietic stem cells
Brian P. Sorrentino Nature Reviews Immunology4, 878–888
(November 2004); doi:10.1038/nri1487
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article S-Glutathiolation by peroxynitrite activates SERCA during arterial relaxation by nitric oxide
Takeshi Adachi, Robert M Weisbrod, David R Pimentel, Jia Ying, Victor S Sharov, Christian Schöneich and Richard A Cohen Nature Medicine10, 1200–1207
(November 2004); doi:10.1038/nm1119
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letter TCR affinity and negative regulation limit autoimmunity
Matthew A Gronski, Jonathan M Boulter, Demetrius Moskophidis, Linh T Nguyen, Kaisa Holmberg, Alisha R Elford, Elissa K Deenick, Hee O Kim, Josef M Penninger, Bernhard Odermatt, Awen Gallimore, Nicholas R J Gascoigne and Pamela S Ohashi Nature Medicine10, 1234–1239
(November 2004); doi:10.1038/nm1114
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news and views H. pylori's inside job
Charlotte Schubert Nature Medicine10, 1164
(November 2004); doi:10.1038/nm1104-1164
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news and views Stem cells bank on ATM machine
Anthony D Whetton Nature Medicine10, 1166–1168
(November 2004); doi:10.1038/nm1104-1166
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review article Friends or foes — bipolar effects of the tumour stroma in cancer
Margareta M. Mueller and Norbert E. Fusenig Nature Reviews Cancer4, 839–849
(November 2004); doi:10.1038/nrc1477
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article RITS acts in cis to promote RNA interference-mediated transcriptional and post-transcriptional silencing
Ken-ichi Noma, Tomoyasu Sugiyama, Hugh Cam, Andre Verdel, Martin Zofall, Songtao Jia, Danesh Moazed and Shiv I S Grewal Nature Genetics36, 1174–1180
(November 2004); doi:10.1038/ng1452
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news and views RNA interference on chromosomes
R Kelly Dawe Nature Genetics36, 1141–1142
(November 2004); doi:10.1038/ng1104-1141
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perspectives Lifespan and mitochondrial control of neurodegeneration
Alan F Wright, Samuel G Jacobson, Artur V Cideciyan, Alejandro J Roman, Xinhua Shu, Dafni Vlachantoni, Roderick R McInnes and Rudolph A Riemersma Nature Genetics36, 1153–1158
(November 2004); doi:10.1038/ng1448
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review article Molecular genetics and genomics of heart failure
Choong-Chin Liew and Victor J. Dzau Nature Reviews Genetics5, 811–825
(November 2004); doi:10.1038/nrg1470
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article Hedgehog signaling from the ZLI regulates diencephalic regional identity
Clemens Kiecker and Andrew Lumsden Nature Neuroscience7, 1242–1249
(November 2004); doi:10.1038/nn1338
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brief communication A de novo mutation affecting human TrkB associated with severe obesity and developmental delay
Giles S H Yeo, Chiao-Chien Connie Hung, Justin Rochford, Julia Keogh, Juliette Gray, Shoba Sivaramakrishnan, Stephen O'Rahilly and I Sadaf Farooqi Nature Neuroscience7, 1187–1189
(November 2004); doi:10.1038/nn1336
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research article Photoswitchable cyan fluorescent protein for protein tracking
Dmitriy M Chudakov, Vladislav V Verkhusha, Dmitry B Staroverov, Ekaterina A Souslova, Sergey Lukyanov and Konstantin A Lukyanov Nature Biotechnology22, 1435–1439
(December 2004); doi:10.1038/nbt1025
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news and views Fluorescent proteins in a new light
Atsushi Miyawaki Nature Biotechnology22, 1374–1376
(November 2004); doi:10.1038/nbt1104-1374
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article Structural basis for the control of translation initiation during stress
Antòn Vila-Sanjurjo, Barbara-S Schuwirth, Cathy W Hau and Jamie H D Cate Nature Structural and Molecular Biology11, 1054–1059
(November 2004); doi:10.1038/nsmb850
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news and views The how and Y of cold shock
Daniel N Wilson and Knud H Nierhaus Nature Structural and Molecular Biology11, 1026–1028
(November 2004); doi:10.1038/nsmb1104-1026
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article Internal recognition through PDZ domain plasticity in the Par-6-Pals1 complex
Rhiannon R Penkert, Heather M DiVittorio and Kenneth E Prehoda Nature Structural and Molecular Biology11, 1122–1127
(November 2004); doi:10.1038/nsmb839
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article Microarray-based, high-throughput gene expression profiling of microRNAs
Peter T Nelson, Don A Baldwin, L Marie Scearce, J Carl Oberholtzer, John W Tobias and Zissimos Mourelatos Nature Methods1, 155–161
(November 2004); doi:10.1038/nmeth717
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news and views The age of high-throughput microRNA profiling
Aurora Esquela-Kerscher and Frank J Slack Nature Methods1, 106–107
(November 2004); doi:10.1038/nmeth1104-106
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review article Escherichia coli acid resistance: tales of an amateur acidophile
John W. Foster Nature Reviews Microbiology2, 898–907
(November 2004); doi:10.1038/nrmicro1021
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article Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
Jürgen Soutschek, Akin Akinc, Birgit Bramlage, Klaus Charisse, Rainer Constien, Mary Donoghue, Sayda Elbashir, Anke Geick, Philipp Hadwiger, Jens Harborth, Matthias John, Venkitasamy Kesavan, Gary Lavine, Rajendra K. Pandey, Timothy Racie, Kallanthottathil G. Rajeev, Ingo Röhl, Ivanka Toudjarska, Gang Wang, Silvio Wuschko, David Bumcrot, Victor Koteliansky, Stefan Limmer, Muthiah Manoharan and Hans-Peter Vornlocher Nature432, 173–178
(11 November 2004); doi:10.1038/nature03121
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article Crystal structure of RecBCD enzyme reveals a machine for processing DNA breaks
Martin R. Singleton, Mark S. Dillingham, Martin Gaudier, Stephen C. Kowalczykowski and Dale B. Wigley Nature432, 187–193
(11 November 2004); doi:10.1038/nature02988
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news and views DNA repair: Big engine finds small breaks
Anna Marie Pyle Nature432, 157–158
(11 November 2004); doi:10.1038/432157a
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letters to nature A pancreatic islet-specific microRNA regulates insulin secretion
Matthew N. Poy, Lena Eliasson, Jan Krutzfeldt, Satoru Kuwajima, Xiaosong Ma, Patrick E. MacDonald, Sébastien Pfeffer, Thomas Tuschl, Nikolaus Rajewsky, Patrik Rorsman and Markus Stoffel Nature432, 226–230
(11 November 2004); doi:10.1038/nature03076
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letters to nature Processing of primary microRNAs by the Microprocessor complex
Ahmet M. Denli, Bastiaan B. J. Tops, Ronald H. A. Plasterk, René F. Ketting and Gregory J. Hannon Nature432, 231–235
(11 November 2004); doi:10.1038/nature03049
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letters to nature The Microprocessor complex mediates the genesis of microRNAs
Richard I. Gregory, Kai-ping Yan, Govindasamy Amuthan, Thimmaiah Chendrimada, Behzad Doratotaj, Neil Cooch and Ramin Shiekhattar Nature432, 235–240
(11 November 2004); doi:10.1038/nature03120
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news and views Medicine: A cholesterol connection in RNAi
John J. Rossi Nature432, 155–156
(11 November 2004); doi:10.1038/432155a
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news and views Plant development: A bunch of leaves
Christopher Surridge Nature432, 161
(11 November 2004); doi:10.1038/432161a
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letter Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
Estela Jacinto, Robbie Loewith, Anja Schmidt, Shuo Lin, Markus A. Rüegg, Alan Hall and Michael N. Hall Nature Cell Biology6, 1122–1128
(November 2004); doi:10.1038/ncb1183
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brief communication Organization of a sterol-rich membrane domain by cdc15p during cytokinesis in fission yeast
Tetsuya Takeda, Toshimitsu Kawate and Fred Chang Nature Cell Biology6, 1142–1144
(November 2004); doi:10.1038/ncb1189
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news and views MRL proteins: Leading Ena/VASP to Ras GTPases
John A. Legg and Laura M. Machesky Nature Cell Biology6, 1015–1017
(November 2004); doi:10.1038/ncb1104-1015
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review article The RAF proteins take centre stage
Claudia Wellbrock, Maria Karasarides and Richard Marais Nature Reviews Molecular Cell Biology5, 875–885
(November 2004); doi:10.1038/nrm1498
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article Induction of T helper type 1-like regulatory cells that express Foxp3 and protect against airway hyper-reactivity
Philippe Stock, Omid Akbari, Gerald Berry, Gordon J Freeman, Rosemarie H DeKruyff and Dale T Umetsu Nature Immunology5, 1149–1156
(November 2004); doi:10.1038/ni1122
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article Conditional deletion of Gata3 shows its essential function in TH1-TH2 responses
Jinfang Zhu, Booki Min, Jane Hu-Li, Cynthia J Watson, Alex Grinberg, Qi Wang, Nigel Killeen, Joseph F Urban, Jr Liying Guo and William E Paul Nature Immunology5, 1157–1165
(November 2004); doi:10.1038/ni1128
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review article Regulatory T cells: friend or foe in immunity to infection?
Kingston H. G. Mills Nature Reviews Immunology4, 841–855
(November 2004); doi:10.1038/nri1485
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article Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis
Hong Wang, Hong Liao, Mahendar Ochani, Marilou Justiniani, Xinchun Lin, Lihong Yang, Yousef Al-Abed, Haichao Wang, Christine Metz, Edmund J Miller, Kevin J Tracey and Luis Ulloa Nature Medicine10, 1216–1221
(November 2004); doi:10.1038/nm1124
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letter The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers
Kwai Wa Cheng, John P Lahad, Wen-lin Kuo, Anna Lapuk, Kyosuke Yamada, Nelly Auersperg, Jinsong Liu, Karen Smith-McCune, Karen H Lu, David Fishman, Joe W Gray and Gordon B Mills Nature Medicine10, 1251–1256
(November 2004); doi:10.1038/nm1125
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technical report Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model
Lene Uhrbom, Edward Nerio and Eric C Holland Nature Medicine10, 1257–1260
(November 2004); doi:10.1038/nm1120
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review article The emerging roles of human tissue kallikreins in cancer
Carla A. Borgoño and Eleftherios P. Diamandis Nature Reviews Cancer4, 876–890
(November 2004); doi:10.1038/nrc1474
| Abstract | Full Text (HTML / PDF) |
letter X-linked inheritance of Fanconi anemia complementation group B
Amom Ruhikanta Meetei, Marieke Levitus, Yutong Xue, Annette L Medhurst, Michel Zwaan, Chen Ling, Martin A Rooimans, Patrick Bier, Maureen Hoatlin, Gerard Pals, Johan P de Winter, Weidong Wang and Hans Joenje Nature Genetics36, 1219–1224
(November 2004); doi:10.1038/ng1458
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news and views A new gene on the X involved in Fanconi anemia
Nazneen Rahman and Alan Ashworth Nature Genetics36, 1142–1143
(November 2004); doi:10.1038/ng1104-1142
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review article Human brain evolution: insights from microarrays
Todd M. Preuss , Mario Càceres , Michael C. Oldham and Daniel H. Geschwind Nature Reviews Genetics5, 850–860
(November 2004); doi:10.1038/nrg1469
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article Focal adhesion kinase in netrin-1 signaling
Xiu-rong Ren, Guo-li Ming, Yi Xie, Yan Hong, Dong-mei Sun, Zhong-qiu Zhao, Zhu Feng, Qiang Wang, Sangwoo Shim, Zhou-feng Chen, Hong-jun Song, Lin Mei and Wen-cheng Xiong Nature Neuroscience7, 1204–1212
(November 2004); doi:10.1038/nn1330
| Abstract | Full Text (HTML/PDF) |
article Activation of FAK and Src are receptor-proximal events required for netrin signaling
Weiquan Li, Jeeyong Lee, Haris G Vikis, Seung-Hee Lee, Guofa Liu, Jennifer Aurandt, Tang-Long Shen, Eric R Fearon, Jun-Lin Guan, Min Han, Yi Rao, Kyonsoo Hong and Kun-Liang Guan Nature Neuroscience7, 1213–1221
(November 2004); doi:10.1038/nn1329
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article Netrin requires focal adhesion kinase and Src family kinases for axon outgrowth and attraction
Guofa Liu, Hilary Beggs, Claudia Jürgensen, Hwan-Tae Park, Hao Tang, Jessica Gorski, Kevin R Jones, Louis F Reichardt, Jane Wu and Yi Rao Nature Neuroscience7, 1222–1232
(November 2004); doi:10.1038/nn1331
| Abstract | Full Text (HTML/PDF) |
review article Recombinant protein folding and misfolding in Escherichia coli
François Baneyx and Mirna Mujacic Nature Biotechnology22, 1399–1408
(November 2004); doi:10.1038/nbt1029
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article Centromeric chromatin exhibits a histone modification pattern that is distinct from both euchromatin and heterochromatin
Beth A Sullivan and Gary H Karpen Nature Structural and Molecular Biology11, 1076–1083
(November 2004); doi:10.1038/nsmb845
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article Regulated interactions of mtHsp70 with Tim44 at the translocon in the mitochondrial inner membrane
Patrick D'Silva, Qinglian Liu, William Walter and Elizabeth A Craig Nature Structural and Molecular Biology11, 1084–1091
(November 2004); doi:10.1038/nsmb846
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news and views Another piece in the transcription initiation puzzle
Francisco J Asturias Nature Structural and Molecular Biology11, 1031–1033
(November 2004); doi:10.1038/nsmb1104-1031
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article Cell-free protein production and labeling protocol for NMR-based structural proteomics
Dmitriy A Vinarov, Betsy L Lytle, Francis C Peterson, Ejan M Tyler, Brian F Volkman and John L Markley Nature Methods1, 149–153
(November 2004); doi:10.1038/nmeth716
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technology feature Bioinformatics—from genes to pathways
Laura Bonetta Nature Methods1, 169–176
(November 2004); doi:10.1038/nmeth1104-169
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review article Genome-scale models of microbial cells: evaluating the consequences of constraints
Nathan D. Price, Jennifer L. Reed and Bernhard Ø. Palsson Nature Reviews Microbiology2, 886–897
(November 2004); doi:10.1038/nrmicro1023
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article Regulation of Bin1 SH3 domain binding by phosphoinositides
Chie Kojima, Ari Hashimoto, Izumi Yabuta, Mayumi Hirose, Shigeru Hashimoto, Yasunori Kanaho, Hideki Sumimoto, Takahisa Ikegami and Hisataka Sabe The EMBO Journal23, 4413–4422
(November 2004); doi:10.1038/sj.emboj.7600442
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article Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics
Tsan Xiao, Junichi Takagi, Barry S. Coller, Jia-Huai Wang and Timothy A. Springer Nature432, 59–67
(04 November 2004); doi:10.1038/nature02976
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news and views Cell biology: Adhesion articulated
A. Paul Mould and Martin J. Humphries Nature432, 27–28
(04 November 2004); doi:10.1038/432027a
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article Insights into assembly from structural analysis of bacteriophage PRD1
Nicola G. A. Abrescia, Joseph J. B. Cockburn , Jonathan M. Grimes, Geoffrey C. Sutton, Jonathan M. Diprose, Sarah J. Butcher, Stephen D. Fuller, Carmen San Martín, Roger M. Burnett, David I. Stuart, Dennis H. Bamford and Jaana K. H. Bamford Nature432, 68–74
(04 November 2004); doi:10.1038/nature03056
| Abstract | Full Text (HTML / PDF) |
letters to nature Baf60c is essential for function of BAF chromatin remodelling complexes in heart development
Heiko Lickert, Jun K. Takeuchi , Ingo von Both, Johnathon R. Walls, Fionnuala McAuliffe, S. Lee Adamson , R. Mark Henkelman, Jeffrey L. Wrana, Janet Rossant and Benoit G. Bruneau Nature432, 107–112
(04 November 2004); doi:10.1038/nature03071
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letters to nature A faux 3′-UTR promotes aberrant termination and triggers nonsense- mediated mRNA decay
Nadia Amrani, Robin Ganesan, Stephanie Kervestin, David A. Mangus, Shubhendu Ghosh and Allan Jacobson Nature432, 112–118
(04 November 2004); doi:10.1038/nature03060
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article A dermal niche for multipotent adult skin-derived precursor cells
Karl J. L. Fernandes, Ian A. McKenzie, Pleasantine Mill, Kristen M. Smith, Mahnaz Akhavan, Fanie Barnabé-Heider, Jeff Biernaskie, Adrienne Junek, Nao R. Kobayashi, Jean G. Toma, David R. Kaplan, Patricia A. Labosky, Victor Rafuse, Chi-Chung Hui and Freda D. Miller Nature Cell Biology6, 1082–1093
(November 2004); doi:10.1038/ncb1181
| Abstract | Full Text (HTML/PDF) |
letter Nitric oxide induces coupling of mitochondrial signalling with the endoplasmic reticulum stress response
Weiming Xu, Lizhi Liu, Ian G. Charles and Salvador Moncada Nature Cell Biology6, 1129–1134
(November 2004); doi:10.1038/ncb1188
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review article RNA and microRNAs in fragile X mental retardation
Peng Jin, Reid S. Alisch and Stephen T. Warren Nature Cell Biology6, 1048–1053
(November 2004); doi:10.1038/ncb1104-1048
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review article A-type lamins: Guardians of the soma?
Chris J. Hutchison and Howard J. Worman Nature Cell Biology6, 1062–1067
(November 2004); doi:10.1038/ncb1104-1062
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review article The LIM domain: from the cytoskeleton to the nucleus
Julie L. Kadrmas and Mary C. Beckerle Nature Reviews Molecular Cell Biology5, 920–931
(November 2004); doi:10.1038/nrm1499
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article CD28 induces immunostimulatory signals in dendritic cells via CD80 and CD86
Ciriana Orabona, Ursula Grohmann, Maria Laura Belladonna, Francesca Fallarino, Carmine Vacca, Roberta Bianchi, Silvia Bozza, Claudia Volpi, Benoît L Salomon, Maria Cristina Fioretti, Luigina Romani and Paolo Puccetti Nature Immunology5, 1134–1142
(November 2004); doi:10.1038/ni1124
| Abstract | Full Text (HTML/PDF) |
news and views CD28-B7 bidirectional signaling: a two-way street to activation
Eric C Logue and William C Sha Nature Immunology5, 1103–1105
(November 2004); doi:10.1038/ni1104-1103
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review article Recent developments in the transcriptional regulation of cytolytic effector cells
Laurie H. Glimcher, Michael J. Townsend, Brandon M. Sullivan and Graham M. Lord Nature Reviews Immunology4, 900–911
(November 2004); doi:10.1038/nri1490
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review article Strategies to enhance T-cell reconstitution in immunocompromised patients
Marcel R. M. van den Brink, Önder Alpdogan and Richard L. Boyd Nature Reviews Immunology4, 856–867
(November 2004); doi:10.1038/nri1484
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article Salt-sensitive hypertension is triggered by Ca2+ entry via Na+/Ca2+ exchanger type-1 in vascular smooth muscle
Takahiro Iwamoto, Satomi Kita, Jin Zhang, Mordecai P Blaustein, Yuji Arai, Shigeru Yoshida, Koji Wakimoto, Issei Komuro and Takeshi Katsuragi Nature Medicine10, 1193–1199
(November 2004); doi:10.1038/nm1118
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news and views Hypertension with a grain of salt
Ursula Danilczyk and Josef Penninger Nature Medicine10, 1163–1164
(November 2004); doi:10.1038/nm1104-1163
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brief communication Short interfering RNA (siRNA) targeting the Lyn kinase induces apoptosis in primary, and drug-resistant, BCR-ABL1(+) leukemia cells
Andrzej Ptasznik, Yuji Nakata, Anna Kalota, Stephen G Emerson and Alan M. Gewirtz Nature Medicine10, 1187–1189
(November 2004); doi:10.1038/nm1127
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review article Antitumour effects of antiretroviral therapy
Paolo Monini, Cecilia Sgadari, Elena Toschi, Giovanni Barillari and Barbara Ensoli Nature Reviews Cancer4, 861–875
(November 2004); doi:10.1038/nrc1479
| Abstract | Full Text (HTML / PDF) |
letter Loss-of-function mutations in LEMD3 result in osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis
Jan Hellemans, Olena Preobrazhenska, Andy Willaert, Philippe Debeer, Peter C M Verdonk, Teresa Costa, Katrien Janssens, Bjorn Menten, Nadine Van Roy, Stefan J T Vermeulen, Ravi Savarirayan, Wim Van Hul, Filip Vanhoenacker, Danny Huylebroeck, Anne De Paepe, Jean-Marie Naeyaert, Jo Vandesompele, Frank Speleman, Kristin Verschueren, Paul J Coucke and Geert R Mortier Nature Genetics36, 1213–1218
(November 2004); doi:10.1038/ng1453
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brief communication Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B
Sandra Hanks, Kim Coleman, Sarah Reid, Alberto Plaja, Helen Firth, David FitzPatrick, Alexa Kidd, Károly Méhes, Richard Nash, Nathanial Robin, Nora Shannon, John Tolmie, John Swansbury, Alexandre Irrthum, Jenny Douglas and Nazneen Rahman Nature Genetics36, 1159–1161
(November 2004); doi:10.1038/ng1449
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news and views From spindle checkpoint to cancer
Christoph Lengauer and Zhenghe Wang Nature Genetics36, 1144–1145
(November 2004); doi:10.1038/ng1104-1144
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article Activity-dependent transcription regulation of PSD-95 by neuregulin-1 and Eos
Jianxin Bao, Hana Lin, Yannan Ouyang, Debin Lei, Abdullah Osman, Tae-Wan Kim, Lin Mei, Penggao Dai, Kevin K Ohlemiller and Richard T Ambron Nature Neuroscience7, 1250–1258
(November 2004); doi:10.1038/nn1342
| Abstract | Full Text (HTML/PDF) |
review article Iron, brain ageing and neurodegenerative disorders
Luigi Zecca, Moussa B. H. Youdim, Peter Riederer, James R. Connor and Robert R. Crichton Nature Reviews Neuroscience5, 863–873
(November 2004); doi:10.1038/nrn1537
| Abstract | Full Text (HTML / PDF) |
review article Functional genomics to new drug targets
Richard Kramer and Dalia Cohen Nature Reviews Drug Discovery3, 965–972
(November 2004); doi:10.1038/nrd1552
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article Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling
Saumendra N Sarkar, Kristi L Peters, Christopher P Elco, Shuji Sakamoto, Srabani Pal and Ganes C Sen Nature Structural and Molecular Biology11, 1060–1067
(November 2004); doi:10.1038/nsmb847
| Abstract | Full Text (HTML/PDF) |
news and views Another detour on the Toll road to the interferon antiviral response
John Hiscott Nature Structural and Molecular Biology11, 1028–1030
(November 2004); doi:10.1038/nsmb1104-1028
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news and views Opening the GAP
Michelle Montoya Nature Structural and Molecular Biology11, 1033
(November 2004); doi:10.1038/nsmb1104-1033
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article Identifying and quantifying in vivo methylation sites by heavy methyl SILAC
Shao-En Ong, Gerhard Mittler and Matthias Mann Nature Methods1, 119–126
(November 2004); doi:10.1038/nmeth715
| Abstract | Full Text (HTML/PDF) |
