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December 2004
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The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.
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article
Genome-wide survey of protein kinases required for cell cycle progression
M. Bettencourt-Dias, R. Giet, R. Sinka, A. Mazumdar, W. G. Lock, F. Balloux, P. J. Zafiropoulos, S. Yamaguchi, S. Winter, R. W. Carthew, M. Cooper, D. Jones, L. Frenz and D. M. Glover
Nature 432, 980–987
(23 December 2004); doi:10.1038/nature03160
| Abstract | Full Text (HTML / PDF) |
letters to nature
Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes
Christian Wolfrum, Esra Asilmaz, Edlira Luca, Jeffrey M. Friedman and Markus Stoffel
Nature 432, 1027–1032
(23 December 2004); doi:10.1038/nature03047
| First Paragraph | Full Text (HTML / PDF) |
news and views
Diabetes: Outfoxing insulin resistance?
Marc Montminy and Seung-Hoi Koo
Nature 432, 958–959
(23 December 2004); doi:10.1038/432958a
| Full Text (HTML / PDF) |
letters to nature
Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages
Antonio Iavarone , Emerson R. King, Xu-Ming Dai, Gustavo Leone, E. Richard Stanley and Anna Lasorella
Nature 432, 1040–1045
(23 December 2004); doi:10.1038/nature03068
| First Paragraph | Full Text (HTML / PDF) |
news and views
Developmental biology: No red cell is an island
James Palis
Nature 432, 964–965
(23 December 2004); doi:10.1038/432964a
| Full Text (HTML / PDF) |
letters to nature
An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division
Ralf Kittler, Gabriele Putz, Laurence Pelletier, Ina Poser, Anne-Kristin Heninger, David Drechsel, Steffi Fischer, Irena Konstantinova, Bianca Habermann, Hannes Grabner, Marie-Laure Yaspo, Heinz Himmelbauer, Bernd Korn, Karla Neugebauer, Maria Teresa Pisabarro and Frank Buchholz
Nature 432, 1036–1040
(23 December 2004); doi:10.1038/nature03159
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I
Jianhang Jia, Chao Tong, Bing Wang, Liping Luo and Jin Jiang
Nature 432, 1045–1050
(23 December 2004); doi:10.1038/nature03179
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Accurate multiplex gene synthesis from programmable DNA microchips
Jingdong Tian, Hui Gong, Nijing Sheng, Xiaochuan Zhou, Erdogan Gulari, Xiaolian Gao and George Church
Nature 432, 1050–1054
(23 December 2004); doi:10.1038/nature03151
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
The transcription factor Ifh1 is a key regulator of yeast ribosomal protein genes
Joseph T. Wade, Daniel B. Hall and Kevin Struhl
Nature 432, 1054–1058
(23 December 2004); doi:10.1038/nature03175
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Growth-regulated recruitment of the essential yeast ribosomal protein gene activator Ifh1
Stephan B. Schawalder, Mehdi Kabani, Isabelle Howald, Urmila Choudhury, Michel Werner and David Shore
Nature 432, 1058–1061
(23 December 2004); doi:10.1038/nature03200
| First Paragraph | Full Text (HTML / PDF) |
letter
Guidance of myocardial patterning in cardiac development by Sema6D reverse signalling
Toshihiko Toyofuku, Hong Zhang, Atsushi Kumanogoh, Noriko Takegahara, Masanori Yabuki, Koichiro Harada, Masatsugu Hori and Hitoshi Kikutani
Nature Cell Biology 6, 1204–1211
(December 2004); doi:10.1038/ncb1193
| First Paragraph | Full Text (HTML/PDF) |
news and views
Invasive growth: A two-way street for semaphorin signalling
Paolo M. Comoglio, Luca Tamagnone and Silvia Giordano
Nature Cell Biology 6, 1155–1157
(December 2004); doi:10.1038/ncb1204-1155
| Full Text (HTML/PDF) |
letter
Rab27A-binding protein Slp2-a is required for peripheral melanosome distribution and elongated cell shape in melanocytes
Taruho S. Kuroda and Mitsunori Fukuda
Nature Cell Biology 6, 1195–1203
(December 2004); doi:10.1038/ncb1197
| First Paragraph | Full Text (HTML/PDF) |
news and views
Progressing actin: Formin as a processive elongation machine
David R. Kovar and Thomas D. Pollard
Nature Cell Biology 6, 1158–1159
(December 2004); doi:10.1038/ncb1204-1158
| Full Text (HTML/PDF) |
review article
The complex architecture of oxygenic photosynthesis
Nathan Nelson and Adam Ben-Shem
Nature Reviews Molecular Cell Biology 5, 971–982
(December 2004); doi:10.1038/nrm1525
| Abstract | Full Text (HTML / PDF) |
article
Distinct T cell dynamics in lymph nodes during the induction of tolerance and immunity
Stéphanie Hugues, Luc Fetler, Laura Bonifaz, Julie Helft, François Amblard and Sebastian Amigorena
Nature Immunology 5, 1235–1242
(December 2004); doi:10.1038/ni1134
| Abstract | Full Text (HTML/PDF) |
article
Visualizing dendritic cell networks in vivo
Randall L Lindquist, Guy Shakhar, Diana Dudziak, Hedda Wardemann, Thomas Eisenreich, Michael L Dustin and Michel C Nussenzweig
Nature Immunology 5, 1243–1250
(December 2004); doi:10.1038/ni1139
| Abstract | Full Text (HTML/PDF) |
news and views
Lead and follow: the dance of the dendritic cell and T cell
Antonio Lanzavecchia and Federica Sallusto
Nature Immunology 5, 1201–1202
(December 2004); doi:10.1038/ni1204-1201
| Full Text (HTML/PDF) |
review article
A BAF-centred view of the immune system
Tian Chi
Nature Reviews Immunology 4, 965–977
(December 2004); doi:10.1038/nri1501
| Abstract | Full Text (HTML / PDF) |
article
Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors
Natalia Issaeva, Przemyslaw Bozko, Martin Enge, Marina Protopopova, Lisette G G C Verhoef, Maria Masucci, Aladdin Pramanik and Galina Selivanova
Nature Medicine 10, 1321–1328
(December 2004); doi:10.1038/nm1146
| Abstract | Full Text (HTML/PDF) |
news and views
Cancer drug discovery: the wisdom of imprecision
Andrei V Gudkov
Nature Medicine 10, 1298–1299
(December 2004); doi:10.1038/nm1204-1298
| Full Text (HTML/PDF) |
letter
Role of ISG15 protease UBP43 (USP18) in innate immunity to viral infection
Kenneth J Ritchie, Chang S Hahn, Keun Il Kim, Ming Yan, Dabralee Rosario, Li Li, Juan Carlos de la Torre and Dong-Er Zhang
Nature Medicine 10, 1374–1378
(December 2004); doi:10.1038/nm1133
| First Paragraph | Full Text (HTML/PDF) |
news and views
Vitamin A helps gut T cells find their way in the dark
Bengt Johansson-Lindbom and William W Agace
Nature Medicine 10, 1300–1301
(December 2004); doi:10.1038/nm1204-1300
| Full Text (HTML/PDF) |
perspectives
Timeline: Gefitinib — a novel targeted approach to treating cancer
Roy S. Herbst, Masahiro Fukuoka and José Baselga
Nature Reviews Cancer 4, 956–965
(December 2004); doi:10.1038/nrc1506
| Abstract | Full Text (HTML / PDF) |
news and views
PTPN22 and autoimmune disease
Katherine A Siminovitch
Nature Genetics 36, 1248–1249
(December 2004); doi:10.1038/ng1204-1248
| Full Text (HTML/PDF) |
review article
When sugars guide axons: insights from heparan sulphate proteoglycan mutants
Jeong-Soo Lee and Chi-Bin Chien
Nature Reviews Genetics 5, 923–935
(December 2004); doi:10.1038/nrg1490
| Abstract | Full Text (HTML / PDF) |
article
The neurotoxic MEC-4(d) DEG/ENaC sodium channel conducts calcium: implications for necrosis initiation
Laura Bianchi, Beate Gerstbrein, Christian Frøkjær-Jensen, Dewey C Royal, Gargi Mukherjee, Mary Anne Royal, Jian Xue, William R Schafer and Monica Driscoll
Nature Neuroscience 7, 1337–1344
(December 2004); doi:10.1038/nn1347
| Abstract | Full Text (HTML/PDF) |
brief communication
Baz, Par-6 and aPKC are not required for axon or dendrite specification in Drosophila
Melissa M Rolls and Chris Q Doe
Nature Neuroscience 7, 1293–1295
(December 2004); doi:10.1038/nn1346
| First Paragraph | Full Text (HTML/PDF) |
research article
Baculovirus expression system for heterologous multiprotein complexes
Imre Berger, Daniel J Fitzgerald and Timothy J Richmond
Nature Biotechnology 22, 1583–1587
(December 2004); doi:10.1038/nbt1036
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news and views
Baculovirus solves a complex problem
Polly Roy
Nature Biotechnology 22, 1527–1528
(December 2004); doi:10.1038/nbt1204-1527
| Full Text (HTML/PDF) |
research article
Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein
Nathan C Shaner, Robert E Campbell, Paul A Steinbach, Ben N G Giepmans, Amy E Palmer and Roger Y Tsien
Nature Biotechnology 22, 1567–1572
(December 2004); doi:10.1038/nbt1037
| First Paragraph | Full Text (HTML/PDF) |
news and views
A new harvest of fluorescent proteins
George H Patterson
Nature Biotechnology 22, 1524–1525
(December 2004); doi:10.1038/nbt1204-1524
| Full Text (HTML/PDF) |
article
Escherichia coli Hfq has distinct interaction surfaces for DsrA, rpoS and poly(A) RNAs
Peter J Mikulecky, Meenakshi K Kaw, Cristin C Brescia, Jennifer C Takach, Darren D Sledjeski and Andrew L Feig
Nature Structural and Molecular Biology 11, 1206–1214
(December 2004); doi:10.1038/nsmb858
| Abstract | Full Text (HTML/PDF) |
news and views
Rec-ing DNA
Michelle Montoya
Nature Structural and Molecular Biology 11, 1162
(December 2004); doi:10.1038/nsmb1204-1162
| Full Text (HTML/PDF) |
article
Three-chromophore FRET microscopy to analyze multiprotein interactions in living cells
Emilia Galperin, Vladislav V Verkhusha and Alexander Sorkin
Nature Methods 1, 209–217
(December 2004); doi:10.1038/nmeth720
| Abstract | Full Text (HTML/PDF) |
review article
Bacterial redox sensors
Jeffrey Green and Mark S. Paget
Nature Reviews Microbiology 2, 954–966
(December 2004); doi:10.1038/nrmicro1022
| Abstract | Full Text (HTML/PDF) |
article
Structural basis for the assembly of a nuclear export complex
Yoshiyuki Matsuura and Murray Stewart
Nature 432, 872–877
(16 December 2004); doi:10.1038/nature03144
| Abstract | Full Text (HTML / PDF) |
news and views
Cell biology: Popping out of the nucleus
André Hoelz and Günter Blobel
Nature 432, 815–816
(16 December 2004); doi:10.1038/432815a
| Full Text (HTML / PDF) |
letters to nature
Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron
Trude H. Flo , Kelly D. Smith , Shintaro Sato, David J. Rodriguez, Margaret A. Holmes, Roland K. Strong, Shizuo Akira and Alan Aderem
Nature 432, 917–921
(16 December 2004); doi:10.1038/nature03104
| First Paragraph | Full Text (HTML / PDF) |
news and views
Cell biology: Iron thievery
Jonathan Barasch and Kiyoshi Mori
Nature 432, 811–813
(16 December 2004); doi:10.1038/432811a
| Full Text (HTML / PDF) |
article
Nuclear actin and myosin I are required for RNA polymerase I transcription
Vlada V. Philimonenko, Jian Zhao, Sebastian Iben, Hana Dingová, Katarína Kyselá, Michal Kahle, Hanswalter Zentgraf, Wilma A. Hofmann, Primal de Lanerolle, Pavel Hozák and Ingrid Grummt
Nature Cell Biology 6, 1165–1172
(December 2004); doi:10.1038/ncb1190
| Abstract | Full Text (HTML/PDF) |
letter
Sorting signals can direct receptor-mediated export of soluble proteins into COPII vesicles
Stefan Otte and Charles Barlowe
Nature Cell Biology 6, 1189–1194
(December 2004); doi:10.1038/ncb1195
| First Paragraph | Full Text (HTML/PDF) |
letter
Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27Kip1 at G1 phase
Takumi Kamura, Taichi Hara, Masaki Matsumoto, Noriko Ishida, Fumihiko Okumura, Shigetsugu Hatakeyama, Minoru Yoshida, Keiko Nakayama and Keiichi I. Nakayama
Nature Cell Biology 6, 1229–1235
(December 2004); doi:10.1038/ncb1194
| First Paragraph | Full Text (HTML/PDF) |
news and views
A second RING to destroy p27Kip1
Ludger Hengst
Nature Cell Biology 6, 1153–1155
(December 2004); doi:10.1038/ncb1204-1153
| Full Text (HTML/PDF) |
review article
Making sense of it all: bacterial chemotaxis
George H. Wadhams and Judith P. Armitage
Nature Reviews Molecular Cell Biology 5, 1024–1037
(December 2004); doi:10.1038/nrm1524
| Abstract | Full Text (HTML / PDF) |
article
Bone marrow plasmacytoid dendritic cells can differentiate into myeloid dendritic cells upon virus infection
Elina I Zuniga, Dorian B McGavern, Jose L Pruneda-Paz, Chao Teng and Michael B A Oldstone
Nature Immunology 5, 1227–1234
(December 2004); doi:10.1038/ni1136
| Abstract | Full Text (HTML/PDF) |
news and views
Are dendritic cells afraid of commitment?
Anne O'Garra and Giorgio Trinchieri
Nature Immunology 5, 1206–1208
(December 2004); doi:10.1038/ni1204-1206
| Full Text (HTML/PDF) |
review article
Plasmacytoid dendritic cells in immunity
Marco Colonna, Giorgio Trinchieri and Yong-Jun Liu
Nature Immunology 5, 1219–1226
(December 2004); doi:10.1038/ni1141
| Abstract | Full Text (HTML/PDF) |
review article
War and peace at mucosal surfaces
Philippe J. Sansonetti
Nature Reviews Immunology 4, 953–964
(December 2004); doi:10.1038/nri1499
| Abstract | Full Text (HTML / PDF) |
article
Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells
Jose M Polo, Tania Dell'Oso, Stella Maris Ranuncolo, Leandro Cerchietti, David Beck, Gustavo F Da Silva, Gilbert G Prive, Jonathan D Licht and Ari Melnick
Nature Medicine 10, 1329–1335
(December 2004); doi:10.1038/nm1134
| Abstract | Full Text (HTML/PDF) |
letter
Adiponectin-mediated modulation of hypertrophic signals in the heart
Rei Shibata, Noriyuki Ouchi, Masahiro Ito, Shinji Kihara, Ichiro Shiojima, David R Pimentel, Masahiro Kumada, Kaori Sato, Stephan Schiekofer, Koji Ohashi, Tohru Funahashi, Wilson S Colucci and Kenneth Walsh
Nature Medicine 10, 1384–1389
(December 2004); doi:10.1038/nm1137
| First Paragraph | Full Text (HTML/PDF) |
technical report
Protein microarrays for multiplex analysis of signal transduction pathways
Steven M Chan, Joerg Ermann, Leon Su, C Garrison Fathman and Paul J Utz
Nature Medicine 10, 1390–1396
(December 2004); doi:10.1038/nm1139
| Abstract | Full Text (HTML/PDF) |
review article
Regulation of the cytoskeleton: an oncogenic function for cdk inhibitors?
Arnaud Besson, Richard K. Assoian and James M. Roberts
Nature Reviews Cancer 4, 948–955
(December 2004); doi:10.1038/nrc1501
| Abstract | Full Text (HTML / PDF) |
letter
Mutations in PTF1A cause pancreatic and cerebellar agenesis
Gabrielle S Sellick, Karen T Barker, Irene Stolte-Dijkstra, Christina Fleischmann, Richard J Coleman, Christine Garrett, Anna L Gloyn, Emma L Edghill, Andrew T Hattersley, Peter K Wellauer, Graham Goodwin and Richard S Houlston
Nature Genetics 36, 1301–1305
(December 2004); doi:10.1038/ng1475
| First Paragraph | Full Text (HTML/PDF) |
article
Math1 regulates development of the sensory epithelium in the mammalian cochlea
Chad Woods, Mireille Montcouquiol and Matthew W Kelley
Nature Neuroscience 7, 1310–1318
(December 2004); doi:10.1038/nn1349
| Abstract | Full Text (HTML/PDF) |
article
Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain
E S Anton, H T Ghashghaei, Janet L Weber, Corey McCann, Tobias M Fischer, Isla D Cheung, Martin Gassmann, Albee Messing, Rudiger Klein, Markus H Schwab, K C Kent Lloyd and Cary Lai
Nature Neuroscience 7, 1319–1328
(December 2004); doi:10.1038/nn1345
| Abstract | Full Text (HTML/PDF) |
review article
Biochemical mechanisms for translational regulation in synaptic plasticity
Eric Klann and Thomas E. Dever
Nature Reviews Neuroscience 5, 931–942
(December 2004); doi:10.1038/nrn1557
| Abstract | Full Text (HTML / PDF) |
research article
Silencing of SOCS1 enhances antigen presentation by dendritic cells and antigen-specific anti-tumor immunity
Lei Shen, Kevin Evel-Kabler, Randy Strube and Si-Yi Chen
Nature Biotechnology 22, 1546–1553
(December 2004); doi:10.1038/nbt1035
| Abstract | Full Text (HTML/PDF) |
news and views
A new harvest of fluorescent proteins
George H Patterson
Nature Biotechnology 22, 1524–1525
(December 2004); doi:10.1038/nbt1204-1524
| Full Text (HTML/PDF) |
research article
Negative feedback inhibition of HIV-1 by TAT-inducible expression of siRNA
Hoshang J Unwalla, Ming-Jie Li, James D Kim, Hai Tang Li, Ali Ehsani, Jessica Alluin and John J Rossi
Nature Biotechnology 22, 1573–1578
(December 2004); doi:10.1038/nbt1040
| First Paragraph | Full Text (HTML/PDF) |
review article
Strategies to overcome resistance to targeted protein kinase inhibitors
Henrik Daub, Katja Specht and Axel Ullrich
Nature Reviews Drug Discovery 3, 1001–1010
(December 2004); doi:10.1038/nrd1579
| Abstract | Full Text (HTML / PDF) |
article
Cell cycle-dependent regulation of yeast telomerase by Ku
Timothy S Fisher, Andrew K P Taggart and Virginia A Zakian
Nature Structural and Molecular Biology 11, 1198–1205
(December 2004); doi:10.1038/nsmb854
| Abstract | Full Text (HTML/PDF) |
news and views
Doing more with less in bacterial DNA repair
Geoffrey R Weller, Vicky L Brandt and David B Roth
Nature Structural and Molecular Biology 11, 1158–1159
(December 2004); doi:10.1038/nsmb1204-1158
| Full Text (HTML/PDF) |
article
Real-time monitoring of ubiquitination in living cells by BRET
Julie Perroy, Stephanie Pontier, Pascale G Charest, Muriel Aubry and Michel Bouvier
Nature Methods 1, 203–208
(December 2004); doi:10.1038/nmeth722
| Abstract | Full Text (HTML/PDF) |
news and views
Resonating to the music of ubiquitination
Sudha K Shenoy and Robert J Lefkowitz
Nature Methods 1, 191–193
(December 2004); doi:10.1038/nmeth1204-191
| Full Text (HTML/PDF) |
article
Scaffolding by ERK3 regulates MK5 in development
Stefanie Schumacher, Kathrin Laaß, Shashi Kant, Yu Shi, Axel Visel, Achim D Gruber, Alexey Kotlyarov and Matthias Gaestel
EMBO Journal 23, 4770–4779
(December 2004); doi:10.1038/sj.emboj.7600467
| Abstract | Full Text (HTML/PDF) |
article
Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway
Ole-Morten Seternes, Theresa Mikalsen, Bjarne Johansen, Espen Michaelsen, Chris G Armstrong, Nick A Morrice, Benjamin Turgeon, Sylvain Meloche, Ugo Moens and Stephen M Keyse
EMBO Journal 23, 4780–4791
(December 2004); doi:10.1038/sj.emboj.7600489
| Abstract | Full Text (HTML/PDF) |
article
TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells
David P. Corey , Jaime García-Añoveros, Jeffrey R. Holt, Kelvin Y. Kwan , Shuh-Yow Lin , Melissa A. Vollrath , Andrea Amalfitano, Eunice L.-M. Cheung, Bruce H. Derfler, Anne Duggan, Gwénaëlle S. G. Géléoc, Paul A. Gray, Matthew P. Hoffman, Heidi L. Rehm, Daniel Tamasauskas and Duan-Sun Zhang
Nature 432, 723–730
(09 December 2004); doi:10.1038/nature03066
| Abstract | Full Text (HTML / PDF) |
news and views
Hearing: Channel at the hair's end
Jonathan Ashmore
Nature 432, 685–686
(09 December 2004); doi:10.1038/432685a
| Full Text (HTML / PDF) |
letters to nature
Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene
Jian-Hua Mao, Jesus Perez-losada, Di Wu, Reyno DelRosario, Ryosuke Tsunematsu, Keiichi I. Nakayama, Ken Brown, Sheila Bryson and Allan Balmain
Nature 432, 775–779
(09 December 2004); doi:10.1038/nature03155
| First Paragraph | Full Text (HTML / PDF) |
letter
Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin
Si Wan Kim, Jae-Il Park, Christopher M. Spring, Amy K. Sater, Hong Ji, Abena A. Otchere, Juliet M. Daniel and Pierre D. McCrea
Nature Cell Biology 6, 1212–1220
(December 2004); doi:10.1038/ncb1191
| First Paragraph | Full Text (HTML/PDF) |
brief communication
Intra-nuclear microtubules and a mitotic spindle orientation checkpoint
Sabina Zimmerman, Rafael R. Daga and Fred Chang
Nature Cell Biology 6, 1245–1246
(December 2004); doi:10.1038/ncb1200
| First Paragraph | Full Text (HTML/PDF) |
news and views
PINOID pinpoints auxin
Myrto Raftopoulou
Nature Cell Biology 6, 1149
(December 2004); doi:10.1038/ncb1204-1149
| Full Text (HTML/PDF) |
news and views
Tudor domains track down DNA breaks
Manuel Stucki and Stephen P. Jackson
Nature Cell Biology 6, 1150–1152
(December 2004); doi:10.1038/ncb1204-1150
| Full Text (HTML/PDF) |
review article
Meiosis: cell-cycle controls shuffle and deal
Adèle L. Marston and Angelika Amon
Nature Reviews Molecular Cell Biology 5, 983–997
(December 2004); doi:10.1038/nrm1526
| Abstract | Full Text (HTML / PDF) |
review article
Viral hijacking of G-protein-coupled-receptor signalling networks
Akrit Sodhi, Silvia Montaner and J. Silvio Gutkind
Nature Reviews Molecular Cell Biology 5, 998–1012
(December 2004); doi:10.1038/nrm1529
| Abstract | Full Text (HTML / PDF) |
article
Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity
K Mark Ansel, Rebecca J Greenwald, Suneet Agarwal, Craig H Bassing, Silvia Monticelli, Jeneen Interlandi, Ivana M Djuretic, Dong U Lee, Arlene H Sharpe, Frederick W Alt and Anjana Rao
Nature Immunology 5, 1251–1259
(December 2004); doi:10.1038/ni1135
| Abstract | Full Text (HTML/PDF) |
hypothesis
Labeled antigens and antibodies: the evolution of magic markers and magic bullets
Arthur M Silverstein
Nature Immunology 5, 1211–1217
(December 2004); doi:10.1038/ni1140
| Abstract | Full Text (HTML/PDF) |
review article
Mechanisms and functional significance of tumour-induced dendritic-cell defects
Dmitry Gabrilovich
Nature Reviews Immunology 4, 941–952
(December 2004); doi:10.1038/nri1498
| Abstract | Full Text (HTML / PDF) |
review article
The immunogenetics of asthma and eczema: a new focus on the epithelium
William Cookson
Nature Reviews Immunology 4, 978–988
(December 2004); doi:10.1038/nri1500
| Abstract | Full Text (HTML / PDF) |
article
Mice lacking calsarcin-1 are sensitized to calcineurin signaling and show accelerated cardiomyopathy in response to pathological biomechanical stress
Norbert Frey, Tomasa Barrientos, John M Shelton, Derk Frank, Hartmut Rütten, Doris Gehring, Christian Kuhn, Matthias Lutz, Beverly Rothermel, Rhonda Bassel-Duby, James A Richardson, Hugo A Katus, Joseph A Hill and Eric N Olson
Nature Medicine 10, 1336–1343
(December 2004); doi:10.1038/nm1132
| Abstract | Full Text (HTML/PDF) |
article
Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins
Weijia Kong, Jing Wei, Parveen Abidi, Meihong Lin, Satoru Inaba, Cong Li, Yanling Wang, Zizheng Wang, Shuyi Si, Huaining Pan, Shukui Wang, Jingdan Wu, Yue Wang, Zhuorong Li, Jingwen Liu and Jian-Dong Jiang
Nature Medicine 10, 1344–1351
(December 2004); doi:10.1038/nm1135
| Abstract | Full Text (HTML/PDF) |
article
Prevention of cholesterol gallstone disease by FXR agonists in a mouse model
Antonio Moschetta, Angie L Bookout and David J Mangelsdorf
Nature Medicine 10, 1352–1358
(December 2004); doi:10.1038/nm1138
| Abstract | Full Text (HTML/PDF) |
news and views
Chipping away at gallstones
Kerry B Goralski and Christopher J Sinal
Nature Medicine 10, 1301–1302
(December 2004); doi:10.1038/nm1204-1301
| Full Text (HTML/PDF) |
news and views
Micromanaging insulin secretion
Craig C Mello and Michael P Czech
Nature Medicine 10, 1297–1298
(December 2004); doi:10.1038/nm1204-1297
| Full Text (HTML/PDF) |
review article
Aurora-kinase inhibitors as anticancer agents
Nicholas Keen and Stephen Taylor
Nature Reviews Cancer 4, 927–936
(December 2004); doi:10.1038/nrc1502
| Abstract | Full Text (HTML / PDF) |
review article
Targeting the mitogen-activated protein kinase cascade to treat cancer
Judith S. Sebolt-Leopold and Roman Herrera
Nature Reviews Cancer 4, 937–947
(December 2004); doi:10.1038/nrc1503
| Abstract | Full Text (HTML / PDF) |
article
Insulin regulation of heart function in aging fruit flies
Robert J Wessells, Erin Fitzgerald, James R Cypser, Marc Tatar and Rolf Bodmer
Nature Genetics 36, 1275–1281
(December 2004); doi:10.1038/ng1476
| Abstract | Full Text (HTML/PDF) |
technical report
Rapid analysis of the DNA-binding specificities of transcription factors with DNA microarrays
Sonali Mukherjee, Michael F Berger, Ghil Jona, Xun S Wang, Dale Muzzey, Michael Snyder, Richard A Young and Martha L Bulyk
Nature Genetics 36, 1331–1339
(December 2004); doi:10.1038/ng1473
| Abstract | Full Text (HTML/PDF) |
brief communication
Adapter protein 14-3-3 is required for a presynaptic form of LTP in the cerebellum
Fatma Simsek-Duran, David J Linden and György Lonart
Nature Neuroscience 7, 1296–1298
(December 2004); doi:10.1038/nn1348
| First Paragraph | Full Text (HTML/PDF) |
review article
Stress, cognitive impairment and cell adhesion molecules
Carmen Sandi
Nature Reviews Neuroscience 5, 917–939
(December 2004); doi:10.1038/nrn1555
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research article
Lack of interferon response in animals to naked siRNAs
Jeremy D Heidel, Siwen Hu, Xian Fang Liu, Timothy J Triche and Mark E Davis
Nature Biotechnology 22, 1579–1582
(December 2004); doi:10.1038/nbt1038
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research article
Antisense and siRNA as agonists of Toll-like receptors
Sudhir Agrawal and Ekambar R Kandimalla
Nature Biotechnology 22, 1533–1537
(December 2004); doi:10.1038/nbt1042
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review article
Development of TGF-β signalling inhibitors for cancer therapy
Jonathan M. Yingling, Kerry L. Blanchard and J. Scott Sawyer
Nature Reviews Drug Discovery 3, 1011–1022
(December 2004); doi:10.1038/nrd1580
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article
Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition
Jeffrey F Ohren, Huifen Chen, Alexander Pavlovsky, Christopher Whitehead, Erli Zhang, Peter Kuffa, Chunhong Yan, Patrick McConnell, Cindy Spessard, Craig Banotai, W Thomas Mueller, Amy Delaney, Charles Omer, Judith Sebolt-Leopold, David T Dudley, Iris K Leung, Cathlin Flamme, Joseph Warmus, Michael Kaufman, Stephen Barrett, Haile Tecle and Charles A Hasemann
Nature Structural and Molecular Biology 11, 1192–1197
(December 2004); doi:10.1038/nsmb859
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Shortcuts to the end
Alberto R Kornblihtt
Nature Structural and Molecular Biology 11, 1156–1157
(December 2004); doi:10.1038/nsmb1204-1156
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Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas
Akira Watahiki, Kazunori Waki, Norihito Hayatsu, Toshiyuki Shiraki, Shinji Kondo, Mari Nakamura, Daisuke Sasaki, Takahiro Arakawa, Jun Kawai, Matthias Harbers, Yoshihide Hayashizaki1 and Piero Carninci
Nature Methods 1, 233–239
(December 2004); doi:10.1038/nmeth719
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review article
Large-scale database searching using tandem mass spectra: Looking up the answer in the back of the book
Rovshan G Sadygov, Daniel Cociorva and John R Yates III
Nature Methods 1, 195–202
(December 2004); doi:10.1038/nmeth725
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A synaptic laminin-calcium channel interaction organizes active zones in motor nerve terminals
Hiroshi Nishimune, Joshua R. Sanes and Steven S. Carlson
Nature 432, 580–587
(02 December 2004); doi:10.1038/nature03112
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article
Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry
Michael Rape and Marc W. Kirschner
Nature 432, 588–595
(02 December 2004); doi:10.1038/nature03023
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Cell division: The heart of the cycle
Jiri Lukas and Jiri Bartek
Nature 432, 564–567
(02 December 2004); doi:10.1038/432564a
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letters to nature
The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells
Ryan T. Phan and Riccardo Dalla-Favera
Nature 432, 635–639
(02 December 2004); doi:10.1038/nature03147
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letters to nature
Regulation of cellular response to oncogenic and oxidative stress by Seladin-1
Chaowei Wu, Irene Miloslavskaya, Silvia Demontis, Roberta Maestro and Konstantin Galaktionov
Nature 432, 640–645
(02 December 2004); doi:10.1038/nature03173
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letters to nature
Poly(ADP-ribose) is required for spindle assembly and structure
Paul Chang, Myron K. Jacobson and Timothy J. Mitchison
Nature 432, 645–649
(02 December 2004); doi:10.1038/nature03061
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news and views
Cytoskeleton: Spindle saga
Eric Karsenti
Nature 432, 563–564
(02 December 2004); doi:10.1038/432563a
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letters to nature
Structure of an auxilin-bound clathrin coat and its implications for the mechanism of uncoating
Alexander Fotin, Yifan Cheng, Nikolaus Grigorieff, Thomas Walz, Stephen C. Harrison and Tomas Kirchhausen
Nature 432, 649–653
(02 December 2004); doi:10.1038/nature03078
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Cell biology: Clathrin's Achilles' ankle
Frances M. Brodsky
Nature 432, 568–569
(02 December 2004); doi:10.1038/432568a
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A novel actin barbed-end-capping activity in EPS-8 regulates apical morphogenesis in intestinal cells of Caenorhabditis elegans
Assunta Croce, Giuseppe Cassata, Andrea Disanza, Maria Cristina Gagliani, Carlo Tacchetti, Maria Grazia Malabarba, Marie-France Carlier, Giorgio Scita, Ralf Baumeister and Pier Paolo Di Fiore
Nature Cell Biology 6, 1173–1179
(December 2004); doi:10.1038/ncb1198
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Eps8 controls actin-based motility by capping the barbed ends of actin filaments
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Nature Cell Biology 6, 1180–1188
(December 2004); doi:10.1038/ncb1199
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There goes the neighbourhood: Eps8 joins the barbed-end crowd
Henry N. Higgs
Nature Cell Biology 6, 1147–1149
(December 2004); doi:10.1038/ncb1204-1147
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The Williams syndrome transcription factor interacts with PCNA to target chromatin remodelling by ISWI to replication foci
Raymond A. Poot, Ludmila Bozhenok, Debbie L.C. van den Berg, Søren Steffensen, Fernando Ferreira, Margaret Grimaldi, Nick Gilbert, Joao Ferreira and Patrick D. Varga-Weisz
Nature Cell Biology 6, 1236–1244
(December 2004); doi:10.1038/ncb1196
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review article
AKAP signalling complexes: focal points in space and time
Wei Wong and John D. Scott
Nature Reviews Molecular Cell Biology 5, 959–970
(December 2004); doi:10.1038/nrm1527
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The double-stranded-RNA-binding motif: interference and much more
Bin Tian, Philip C. Bevilacqua, Amy Diegelman-Parente and Michael B. Mathews
Nature Reviews Molecular Cell Biology 5, 1013–1023
(December 2004); doi:10.1038/nrm1528
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Induced recruitment of NK cells to lymph nodes provides IFN-γ for TH1 priming
Alfonso Martín-Fontecha, Lindy L Thomsen, Sara Brett, Craig Gerard, Martin Lipp, Antonio Lanzavecchia and Federica Sallusto
Nature Immunology 5, 1260–1265
(December 2004); doi:10.1038/ni1138
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Disruption of Erk-dependent type I interferon induction breaks the myxoma virus species barrier
Fuan Wang, Yiyue Ma, John W Barrett, Xiujuan Gao, Joy Loh, Erik Barton, Herbert W Virgin and IV Grant McFadden
Nature Immunology 5, 1266–1274
(December 2004); doi:10.1038/ni1132
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Why are rabbits uniquely sensitive to myxoma virus? Cherchez l'interferon!
Jan Vilček
Nature Immunology 5, 1205–1206
(December 2004); doi:10.1038/ni1204-1205
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Consequences of regulated pre-mRNA splicing in the immune system
Kristen W. Lynch
Nature Reviews Immunology 4, 931–940
(December 2004); doi:10.1038/nri1497
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Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis
Tian Wang, Terrence Town, Lena Alexopoulou, John F Anderson, Erol Fikrig and Richard A Flavell
Nature Medicine 10, 1366–1373
(December 2004); doi:10.1038/nm1140
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West Nile virus: crossing the blood-brain barrier
Michael S Diamond and Robyn S Klein
Nature Medicine 10, 1294–1295
(December 2004); doi:10.1038/nm1204-1294
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Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C
Dong Liu, Tong Cheng, Huang Guo, José A Fernández, John H Griffin, Xiaomei Song and Berislav V Zlokovic
Nature Medicine 10, 1379–1383
(December 2004); doi:10.1038/nm1122
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Combination stroke therapy: easy as APC?
Eng H Lo
Nature Medicine 10, 1295–1296
(December 2004); doi:10.1038/nm1204-1295
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The role of the unfolded protein response in tumour development: friend or foe?
Yanjun Ma and Linda M. Hendershot
Nature Reviews Cancer 4, 966–977
(December 2004); doi:10.1038/nrc1505
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Netrin-1 and its receptors in tumorigenesis
Hirofumi Arakawa
Nature Reviews Cancer 4, 978–987
(December 2004); doi:10.1038/nrc1504
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Imprinting on distal chromosome 7 in the placenta involves repressive histone methylation independent of DNA methylation
Annabelle Lewis, Kohzoh Mitsuya, David Umlauf, Paul Smith, Wendy Dean, Joern Walter, Michael Higgins, Robert Feil and Wolf Reik
Nature Genetics 36, 1291–1295
(December 2004); doi:10.1038/ng1468
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Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes
David Umlauf, Yuji Goto, Ru Cao, Frédérique Cerqueira, Alexandre Wagschal, Yi Zhang and Robert Feil
Nature Genetics 36, 1296–1300
(December 2004); doi:10.1038/ng1467
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The genetics of cell death: approaches, insights and opportunities in Drosophila
Bruce A. Hay, Jun R. Huh and Ming Guo
Nature Reviews Genetics 5, 911–922
(December 2004); doi:10.1038/nrg1491
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Zebrafish unplugged reveals a role for muscle-specific kinase homologs in axonal pathway choice
Jing Zhang, Julie L Lefebvre, Shuxia Zhao & Michael Granato
Nature Neuroscience 7, 1303–1309
(December 2004); doi:10.1038/nn1350
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technical review
Light-activated ion channels for remote control of neuronal firing
Matthew Banghart, Katharine Borges, Ehud Isacoff, Dirk Trauner and Richard H Kramer
Nature Neuroscience 7, 1381–1386
(December 2004); doi:10.1038/nn1356
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A molecular light switch turns off neural activity
Cara Allen
Nature Neuroscience 7, 1291
(December 2004); doi:10.1038/nn1204-1291
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Receptor trafficking and synaptic plasticity
Graham L. Collingridge , John T. R. Isaac and Yu Tian Wang
Nature Reviews Neuroscience 5, 952–962
(December 2004); doi:10.1038/nrn1556
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Making protein interactions druggable: targeting PDZ domains
Kumlesh K. Dev
Nature Reviews Drug Discovery 3, 1047–1056
(December 2004); doi:10.1038/nrd1578
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Human CD59 is a receptor for the cholesterol-dependent cytolysin intermedilysin
Kara S Giddings, Ji Zhao, Peter J Sims and Rodney K Tweten
Nature Structural and Molecular Biology 11, 1173–1178
(December 2004); doi:10.1038/nsmb862
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Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection
Ming Lei, Elaine R Podell and Thomas R Cech
Nature Structural and Molecular Biology 11, 1223–1229
(December 2004); doi:10.1038/nsmb867
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A bacterial big-MAC attack
Ioan Iacovache and F Gisou van der Goot
Nature Structural and Molecular Biology 11, 1163–1164
(December 2004); doi:10.1038/nsmb1204-1163
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Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection
Ming Lei, Elaine R Podell and Thomas R Cech
Nature Structural and Molecular Biology 11, 1223–1229
(December 2004); doi:10.1038/nsmb867
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High-throughput localization of functional elements by quantitative chromatin profiling
Michael O Dorschner, Michael Hawrylycz, Richard Humbert, James C Wallace, Anthony Shafer, Janelle Kawamoto, Joshua Mack, Robert Hall, Jeff Goldy, Peter J Sabo, Ajay Kohli, Qiliang Li, Michael McArthur and John A Stamatoyannopoulos
Nature Methods 1, 219–225
(December 2004); doi:10.1038/nmeth721
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review
The evolution of chronic infection strategies in the α-proteobacteria
Jacques Batut, Siv G. E. Andersson and David O'Callaghan
Nature Reviews Microbiology 2, 933–945
(December 01 2004); doi:10.1038/nrmicro1044
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