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February 2005
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The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.
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article
The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment
Xiao He, Xi He, Vibhuti P. Dave, Yi Zhang, Xiang Hua, Emmanuelle Nicolas, Weihong Xu, Bruce A. Roe and Dietmar J. Kappes
Nature 433, 826–833
(24 February 2005); doi:10.1038/nature03338
| Summary | Full Text (HTML / PDF) |
letters to nature
CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains
Paola Vergani, Steve W. Lockless, Angus C. Nairn and David C. Gadsby
Nature 433, 876–880
(24 February 2005); doi:10.1038/nature03313
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Pax3 functions at a nodal point in melanocyte stem cell differentiation
Deborah Lang, Min Min Lu, Li Huang, Kurt A. Engleka, Maozhen Zhang, Emily Y. Chu, Shari Lipner, Arthur Skoultchi, Sarah E. Millar and Jonathan A. Epstein
Nature 433, 884–887
(24 February 2005); doi:10.1038/nature03292
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Toll-like receptor 3 promotes cross-priming to virus-infected cells
Oliver Schulz, Sandra S. Diebold, Margaret Chen, Tanja I. Näslund, Martijn A. Nolte, Lena Alexopoulou, Yasu-Taka Azuma, Richard A. Flavell, Peter Liljeström and Caetano Reis e Sousa
Nature 433, 887–892
(24 February 2005); doi:10.1038/nature03326
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
State transitions and light adaptation require chloroplast thylakoid protein kinase STN7
Stéphane Bellafiore, Frédy Barneche, Gilles Peltier and Jean-David Rochaix
Nature 433, 892–895
(24 February 2005); doi:10.1038/nature03286
| First Paragraph | Full Text (HTML / PDF) |
news and views
Immunology: Guide for a cell-fate decision
Ellen A. Robey
Nature 433, 813–814
(24 February 2005); doi:10.1038/433813a
| Full Text (HTML / PDF) |
news and views
Human immunodeficiency virus: Refolding the envelope
Peter D. Kwong
Nature 433, 815–816
(24 February 2005); doi:10.1038/433815a
| Full Text (HTML / PDF) |
letter
Basic mechanism of three-dimensional collagen fibre transport by fibroblasts
Adam S. Meshel, Qize Wei, Robert S. Adelstein and Michael P. Sheetz
Nature Cell Biology 7, 157–164
(February 2005); doi:10.1038/ncb1216
| First Paragraph | Full Text (HTML/PDF) |
letter
Negative cell-cycle regulators cooperatively control self-renewal and differentiation of haematopoietic stem cells
Carl R. Walkley, Matthew L. Fero, Wei-Ming Chien, Louise E. Purton and Grant A. McArthur
Nature Cell Biology 7, 172–178
(February 2005); doi:10.1038/ncb1214
| First Paragraph | Full Text (HTML/PDF) |
letter
OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes
Shinichi Kondo, Tomohiko Murakami, Kouko Tatsumi, Maiko Ogata, Soshi Kanemoto, Kumi Otori, Ken Iseki, Akio Wanaka and Kazunori Imaizumi
Nature Cell Biology 7, 186–194
(February 2005); doi:10.1038/ncb1213
| First Paragraph | Full Text (HTML/PDF) |
review article
Assembly and function of RNA silencing complexes
Erik J. Sontheimer
Nature Reviews Molecular Cell Biology 6, 127–138
(February 2005); doi:10.1038/nrm1568
| Summary | Full Text (HTML / PDF) |
article
Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141
Peter Tomasec, Eddie C Y Wang, Andrew J Davison, Borivoj Vojtesek, Melanie Armstrong, Cora Griffin, Brian P McSharry, Rebecca J Morris, Sian Llewellyn-Lacey, Carole Rickards, Akio Nomoto, Christian Sinzger and Gavin W G Wilkinson
Nature Immunology 6, 181–188
(February 2005); doi:10.1038/ni1156
| Abstract | Full Text (HTML/PDF) |
review article
Roles of interferon-regulatory factors in T-helper-cell differentiation
Michael Lohoff and Tak W. Mak
Nature Reviews Immunology 5, 125–135
(February 2005); doi:10.1038/nri1552
| Summary | Full Text (HTML / PDF) |
article
Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
Dongsheng Cai, Minsheng Yuan, Daniel F Frantz, Peter A Melendez, Lone Hansen, Jongsoon Lee and Steven E Shoelson
Nature Medicine 11, 183–190
(February 2005); doi:10.1038/nm1166
| Abstract | Full Text (HTML/PDF) |
article
IKK-β links inflammation to obesity-induced insulin resistance
Melek C Arkan, Andrea L Hevener, Florian R Greten, Shin Maeda, Zhi-Wei Li, Jeffrey M Long, Anthony Wynshaw-Boris, Giuseppe Poli, Jerrold Olefsky and Michael Karin
Nature Medicine 11, 191–198
(February 2005); doi:10.1038/nm1185
| Abstract | Full Text (HTML/PDF) |
article
Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity
Mark W Sleeman, Katherine E Wortley, Ka-Man V Lai, Lori C Gowen, Jennifer Kintner, William O Kline, Karen Garcia, Trevor N Stitt, George D Yancopoulos, Stanley J Wiegand and David J Glass
Nature Medicine 11, 199–205
(February 2005); doi:10.1038/nm1178
| Abstract | Full Text (HTML/PDF) |
news and views
Staying in SHIP shape
Stuart J Decker and Alan R Saltiel
Nature Medicine 11, 123–124
(February 2005); doi:10.1038/nm0205-123
| Full Text (HTML/PDF) |
letter
An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas
Paul Roepman, Lodewyk F A Wessels, Nienke Kettelarij, Patrick Kemmeren, Antony J Miles, Philip Lijnzaad, Marcel G J Tilanus, Ronald Koole, Gert-Jan Hordijk, Peter C van der Vliet, Marcel J T Reinders, Piet J Slootweg and Frank C P Holstege
Nature Genetics 37, 182–186
(February 2005); doi:10.1038/ng1502
| First Paragraph | Full Text (HTML/PDF) |
letter
Polyglutamine expansion of huntingtin impairs its nuclear export
Jonathan Cornett, Fengli Cao, Chuan-En Wang, Christopher A Ross, Gillian P Bates, Shi-Hua Li and Xiao-Jiang Li
Nature Genetics 37, 198–204
(February 2005); doi:10.1038/ng1503
| First Paragraph | Full Text (HTML/PDF) |
review article
Lipid regulation of the synaptic vesicle cycle
Jeffrey Rohrbough and Kendal Broadie
Nature Reviews Neuroscience 6, 139–150
(February 2005); doi:10.1038/nrn1608
| Summary | Full Text (HTML / PDF) |
research article
Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy
Dong-Ho Kim, Mark A Behlke, Scott D Rose, Mi-Sook Chang, Sangdun Choi and John J Rossi
Nature Biotechnology 23, 222–226
(February 2005); doi:10.1038/nbt1051
| First Paragraph | Full Text (HTML/PDF) |
letter
Synthetic shRNAs as potent RNAi triggers
Despina Siolas, Cara Lerner, Julja Burchard, Wei Ge, Peter S Linsley, Patrick J Paddison, Gregory J Hannon and Michele A Cleary
Nature Biotechnology 23, 227–231
(February 2005); doi:10.1038/nbt1052
| First Paragraph | Full Text (HTML/PDF) |
news and views
Dicing with siRNA
Bryan R.G. Williams
Nature Biotechnology 23, 181–182
(February 2005); doi:10.1038/nbt0205-181
| Full Text (HTML/PDF) |
article
Structure of the p115RhoGEF rgRGS domain-Gα13/i1 chimera complex suggests convergent evolution of a GTPase activator
Zhe Chen, William D Singer, Paul C Sternweis and Stephen R Sprang
Nature Structural and Molecular Biology 12, 191–197
(February 2005); doi:10.1038/nsmb888
| Abstract | Full Text (HTML/PDF) |
news and views
ACEing GPI release
Satyajit Mayor
Nature Structural and Molecular Biology 12, 107–108
(February 2005); doi:10.1038/nsmb0205-107
| Full Text (HTML/PDF) |
article
Localized transfection on arrays of magnetic beads coated with PCR products
Mark Isalan, Maria Isabel Santori, Cayetano Gonzalez and Luis Serrano
Nature Methods 2, 113–118
(February 2005); doi:10.1038/nmeth732
| Abstract | Full Text (HTML/PDF) |
review article
Promoters in the environment: transcriptional regulation in its natural context
Ildefonso Cases and Víctor de Lorenzo
Nature Reviews Microbiology 3, 105–118
(February 2005); doi:10.1038/nrmicro1084
| Summary | Full Text (HTML / PDF) |
review article
The multifarious, multireplicon burkholderia cepacia complex
Eshwar Mahenthiralingam, Teresa A. Urban and Joanna B. Goldberg
Nature Reviews Microbiology 3, 144–156
(February 2005); doi:10.1038/nrmicro1085
| Summary | Full Text (HTML / PDF) |
article
ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and β-catenin nuclear signalling
Karina Reiss, Thorsten Maretzky, Andreas Ludwig, Thomas Tousseyn, Bart de Strooper, Dieter Hartmann and Paul Saftig
EMBO Journal 24, 742–752
(February 2005); doi:10.1038/sj.emboj.7600548
| Abstract | Full Text (HTML/PDF) |
article
Ras binding opens c-Raf to expose the docking site for mitogen-activated protein kinase kinase
Kenta Terai and Michiyuki Matsuda
EMBO Reports AOP
(11 February 2005); doi:10.1038/sj.embor.7400349
| Abstract | Full Text (HTML/PDF) |
letters to nature
DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans
Ravi Jagasia , Phillip Grote, Benedikt Westermann and Barbara Conradt
Nature 433, 754–760
(17 February 2005); doi:10.1038/nature03316
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
Irina M. Conboy , Michael J. Conboy, Amy J. Wagers, Eric R. Girma, Irving L. Weissman and Thomas A. Rando
Nature 433, 760–764
(17 February 2005); doi:10.1038/nature03260
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letters to nature
Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression
Suzanne Carreira, Jane Goodall, Isil Aksan, S. Anna La Rocca, Marie-Dominique Galibert, Laurence Denat, Lionel Larue and Colin R. Goding
Nature 433, 764–769
(17 February 2005); doi:10.1038/nature03269
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
Lee P. Lim, Nelson C. Lau, Philip Garrett-Engele, Andrew Grimson, Janell M. Schelter, John Castle, David P. Bartel, Peter S. Linsley and Jason M. Johnson
Nature 433, 769–773
(17 February 2005); doi:10.1038/nature03315
| First Paragraph | Full Text (HTML / PDF) |
article
SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells
Sebastian Leidel, Marie Delattre, Lorenzo Cerutti, Karine Baumer and Pierre Gönczy
Nature Cell Biology 7, 115–125
(February 2005); doi:10.1038/ncb1220
| Abstract | Full Text (HTML/PDF) |
letter
Myosin-XVa is required for tip localization of whirlin and differential elongation of hair-cell stereocilia
Inna A. Belyantseva, Erich T. Boger, Sadaf Naz, Gregory I. Frolenkov, James R. Sellers, Zubair M. Ahmed, Andrew J. Griffith and Thomas B. Friedman
Nature Cell Biology 7, 148–156
(February 2005); doi:10.1038/ncb1219
| First Paragraph | Full Text (HTML/PDF) |
letter
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair
Claus Storgaard Sørensen, Lasse Tengbjerg Hansen, Jaroslaw Dziegielewski, Randi G. Syljuåsen, Cecilia Lundin, Jiri Bartek and Thomas Helleday
Nature Cell Biology 7, 195–201
(February 2005); doi:10.1038/ncb1212
| First Paragraph | Full Text (HTML/PDF) |
news and views
Expanding dynamin: from fission to fusion
Karolina Peplowska and Christian Ungermann
Nature Cell Biology 7, 103–104
(February 2005); doi:10.1038/ncb0205-103
| Full Text (HTML/PDF) |
review article
Reconstruction of cellular signalling networks and analysis of their properties
Jason A. Papin , Tony Hunter, Bernhard O. Palsson and Shankar Subramaniam
Nature Reviews Molecular Cell Biology 6, 99–111
(2005); doi:10.1038/nrm1570
| Summary | Full Text (HTML / PDF) |
article
CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2
Xuguang Tai, Michelle Cowan, Lionel Feigenbaum and Alfred Singer
Nature Immunology 6, 152–162
(February 2005); doi:10.1038/ni1160
| Abstract | Full Text (HTML/PDF) |
review article
Close encounters of different kinds: Dendritic cells and NK cells take centre stage
Mariapia A. Degli-Esposti and Mark J. Smyth
Nature Reviews Immunology 5, 112–124
(February 2005); doi:10.1038/nri1549
| Summary | Full Text (HTML / PDF) |
article
Cathepsin L is required for endothelial progenitor cell-induced neovascularization
Carmen Urbich, Christopher Heeschen, Alexandra Aicher, Ken-ichiro Sasaki, Thomas Bruhl, Mohammad R Farhadi, Peter Vajkoczy, Wolf K Hofmann, Christoph Peters, Len A Pennacchio, Nasreddin D Abolmaali, Emmanouil Chavakis, Thomas Reinheckel, Andreas M Zeiher and Stefanie Dimmeler
Nature Medicine 11, 206–213
(February 2005); doi:10.1038/nm1182
| Abstract | Full Text (HTML/PDF) |
article
Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy
Eiki Takimoto, Hunter C Champion, Manxiang Li, Diego Belardi, Shuxun Ren, E Rene Rodriguez, Djahida Bedja, Kathleen L Gabrielson, Yibin Wang and David A Kass
Nature Medicine 11, 214–222
(February 2005); doi:10.1038/nm1175
| Abstract | Full Text (HTML/PDF) |
news and views
Viagra: now mending hearts
Michael E Mendelsohn
Nature Medicine 11, 115–116
(February 2005); doi:10.1038/nm0205-115
| Full Text (HTML/PDF) |
letter
Uridine adenosine tetraphosphate: a novel endothelium- derived vasoconstrictive factor
Vera Jankowski, Markus Tölle, Raymond Vanholder, Gilbert Schönfelder, Markus van der Giet, Lars Henning, Hartmut Schlüter, Martin Paul, Walter Zidek and Joachim Jankowski
Nature Medicine 11, 223–227
(February 2005); doi:10.1038/nm1188
| First Paragraph | Full Text (HTML/PDF) |
letter
Human telomeric protein TRF2 associates with genomic double-strand breaks as an early response to DNA damage
Paul S Bradshaw, Dimitrios J Stavropoulos and M Stephen Meyn
Nature Genetics 37, 193–197
(February 2005); doi:10.1038/ng1506
| First Paragraph | Full Text (HTML/PDF) |
news and views
Telomere-binding factors and general DNA repair
Woodring E Wright and Jerry W Shay
Nature Genetics 37, 116–118
(February 2005); doi:10.1038/ng0205-116
| Full Text (HTML/PDF) |
article
An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis
Hideki Kizawa, Ikuyo Kou, Aritoshi Iida, Akihiro Sudo, Yoshinari Miyamoto, Akira Fukuda, Akihiko Mabuchi, Akihiro Kotani, Akira Kawakami, Seizo Yamamoto, Atsumasa Uchida, Kozo Nakamura, Kohei Notoya, Yusuke Nakamura and Shiro Ikegawa
Nature Genetics 37, 138–144
(February 2005); doi:10.1038/ng1496
| Abstract | Full Text (HTML/PDF) |
article
Endocytosis-dependent desensitization and protein synthesis-dependent resensitization in retinal growth cone adaptation
Michael Piper, Saif Salih, Christine Weinl, Christine E Holt and William A Harris
Nature Neuroscience 8, 179–186
(February 2005); doi:10.1038/nn1380
| Abstract | Full Text (HTML/PDF) |
review article
The organization of recent and remote memories
Paul W. Frankland and Bruno Bontempi
Nature Reviews Neuroscience 6, 119–130
(February 2005); doi:10.1038/nrn1607
| Summary | Full Text (HTML / PDF) |
research article
Specification of motoneurons from human embryonic stem cells
Xue-Jun Li, Zhong-Wei Du, Ewa D Zarnowska, Matthew Pankratz, Lauren O Hansen, Robert A Pearce and Su-Chun Zhang
Nature Biotechnology 23, 215–221
(February 2005); doi:10.1038/nbt1063
| First Paragraph | Full Text (HTML/PDF) |
research article
Biosynthetic labeling of RNA with uracil phosphoribosyltransferase allows cell-specific microarray analysis of mRNA synthesis and decay
Michael D Cleary, Christopher D Meiering, Eric Jan, Rebecca Guymon and John C Boothroyd
Nature Biotechnology 23, 232–237
(February 2005); doi:10.1038/nbt1061
| First Paragraph | Full Text (HTML/PDF) |
news and views
A window on the dynamics of biological switches
Michael Bittner
Nature Biotechnology 23, 183–184
(February 2005); doi:10.1038/nbt0205-183
| Full Text (HTML/PDF) |
article
The yeast DASH complex forms closed rings on microtubules
JJ L Miranda, Peter De Wulf, Peter K Sorger and Stephen C Harrison
Nature Structural and Molecular Biology 12, 138–143
(February 2005); doi:10.1038/nsmb896
| Abstract | Full Text (HTML/PDF) |
article
Dissection of COPII subunit-cargo assembly and disassembly kinetics during Sar1p-GTP hydrolysis
Ken Sato and Akihiko Nakano
Nature Structural and Molecular Biology 12, 167–174
(February 2005); doi:10.1038/nsmb893
| Abstract | Full Text (HTML/PDF) |
news and views
Illuminating COPII coat dynamics
Wei Liu and Jennifer Lippincott-Schwartz
Nature Structural and Molecular Biology 12, 106–107
(February 2005); doi:10.1038/nsmb0205-106
| Full Text (HTML/PDF) |
article
An extracellular matrix microarray for probing cellular differentiation
Christopher J Flaim, Shu Chien and Sangeeta N Bhatia
Nature Methods 2, 119–125
(February 2005); doi:10.1038/nmeth736
| Abstract | Full Text (HTML/PDF) |
review article
DNA supercoiling — a global transcriptional regulator for enterobacterial growth?
Andrew Travers and Georgi Muskhelishvili
Nature Reviews Microbiology 3, 157–169
(February 2005); doi:10.1038/nrmicro1088
| Summary | Full Text (HTML / PDF) |
letters to nature
Gene transfer to plants by diverse species of bacteria
Wim Broothaerts, Heidi J. Mitchell, Brian Weir, Sarah Kaines, Leon M. A. Smith, Wei Yang, Jorge E. Mayer, Carolina Roa-Rodríguez and Richard A. Jefferson
Nature 433, 629–633
(10 February 2005); doi:10.1038/nature03309
| First Paragraph | Full Text (HTML / PDF) |
news and views
Agricultural biotechnology: Gene exchange by design
Stanton B. Gelvin
Nature 433, 583–584
(10 February 2005); doi:10.1038/433583a
| Full Text (HTML / PDF) |
letters to nature
The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction
Haijuan Yang, Qiubai Li, Jie Fan, William K. Holloman and Nikola P. Pavletich
Nature 433, 653–657
(10 February 2005); doi:10.1038/nature03234
| First Paragraph | Full Text (HTML / PDF) |
news and views
Cancer: Catalyst of a catalyst
Stephen C. Kowalczykowski
Nature 433, 591–592
(10 February 2005); doi:10.1038/433591a
| Full Text (HTML / PDF) |
letters to nature
Structural basis for substrate binding, cleavage and allostery in the tRNA maturase RNase Z
Inés Li De La Sierra-Gallay, Olivier Pellegrini and Ciarán Condon
Nature 433, 657–661
(10 February 2005); doi:10.1038/nature03284
| First Paragraph | Full Text (HTML / PDF) |
article
FoxM1 is required for execution of the mitotic programme and chromosome stability
Jamila Laoukili, Matthijs R. H. Kooistra, Alexandra Brás, Jos Kauw, Ron M. Kerkhoven, Ashby Morrison, Hans Clevers and René H. Medema
Nature Cell Biology 7, 126–136
(February 2005); doi:10.1038/ncb1217
| Abstract | Full Text (HTML/PDF) |
news and views
FoxM1 dances with mitosis
Robert H. Costa
Nature Cell Biology 7, 108–110
(February 2005); doi:10.1038/ncb0205-108
| Full Text (HTML/PDF) |
letter
p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression
Tongxiang Lin, Connie Chao, Shin'ichi Saito, Sharlyn J. Mazur, Maureen E. Murphy, Ettore Appella and Yang Xu
Nature Cell Biology 7, 165–171
(February 2005); doi:10.1038/ncb1211
| First Paragraph | Full Text (HTML/PDF) |
review article
Histone variants meet their match
Kavitha Sarma and Danny Reinberg
Nature Reviews Molecular Cell Biology 6, 139–149
(February 2005); doi:10.1038/nrm1567
| Summary | Full Text (HTML / PDF) |
review article
GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors
Kent L. Rossman , Channing J. Der and John Sondek
Nature Reviews Molecular Cell Biology 6, 167–180
(February 2005); doi:10.1038/nrm1587
| Summary | Full Text (HTML / PDF) |
article
Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4+ T cell populations lacking helper function
Roman Spörri and Caetano Reis e Sousa
Nature Immunology 6, 163–170
(February 2005); doi:10.1038/ni1162
| Abstract | Full Text (HTML/PDF) |
news and views
No driving without a license
William R Heath and Jose A Villadangos
Nature Immunology 6, 125–126
(February 2005); doi:10.1038/ni0205-125
| Full Text (HTML/PDF) |
review article
Host persistence: exploitation of anti-inflammatory pathways by Toxoplasma GONDII
Julio Aliberti
Nature Reviews Immunology 5, 162–170
(February 2005); doi:10.1038/nri1547
| Summary | Full Text (HTML / PDF) |
article
Re-engineered CD40 receptor enables potent pharmacological activation of dendritic-cell cancer vaccines in vivo
Brent A Hanks, Jianghong Jiang, Rana A K Singh, Weitao Song, Michael Barry, Mary H Huls, Kevin M Slawin and David M Spencer
Nature Medicine 11, 130–137
(February 2005); doi:10.1038/nm1183
| Abstract | Full Text (HTML/PDF) |
article
Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice
Tohru Uchida, Takehiro Nakamura, Naoko Hashimoto, Tomokazu Matsuda, Ko Kotani, Hiroshi Sakaue, Yoshiaki Kido, Yoshitake Hayashi, Keiichi I Nakayama, Morris F White and Masato Kasuga
Nature Medicine 11, 175–182
(February 2005); doi:10.1038/nm1187
| Abstract | Full Text (HTML/PDF) |
article
Accelerated re-epithelialization in β3-integrin-deficient- mice is associated with enhanced TGF-β1 signaling
L E Reynolds, F J Conti, M Lucas, R Grose, S Robinson, M Stone, G Saunders, C Dickson, R O Hynes, A Lacy-Hulbert and K Hodivala-Dilke
Nature Medicine 11, 167–174
(February 2005); doi:10.1038/nm1165
| Abstract | Full Text (HTML/PDF) |
article
Angiotensin-converting enzyme is a GPI-anchored protein releasing factor crucial for fertilization
Gen Kondoh, Hiromasa Tojo, Yuka Nakatani, Nobuyasu Komazawa, Chie Murata, Kazuo Yamagata, Yusuke Maeda, Taroh Kinoshita, Masaru Okabe, Ryo Taguchi and Junji Takeda
Nature Medicine 11, 160–166
(February 2005); doi:10.1038/nm1179
| Abstract | Full Text (HTML/PDF) |
news and views
ACE sets up fertilization
Pierre Corvol
Nature Medicine 11, 118–119
(February 2005); doi:10.1038/nm0205-118
| Full Text (HTML/PDF) |
review article
Bleomycins: towards better therapeutics
Jingyang Chen and JoAnne Stubbe
Nature Reviews Cancer 5, 102–112
(February 2005); doi:10.1038/nrc1547
| Summary | Full Text (HTML / PDF) |
article
The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality
Thomas M Johnson, Ester M Hammond, Amato Giaccia and Laura D Attardi
Nature Genetics 37, 145–152
(February 2005); doi:10.1038/ng1498
| Abstract | Full Text (HTML/PDF) |
article
Activity-dependent liberation of synaptic neuropeptide vesicles
Dinara Shakiryanova, Arvonn Tully, Randall S Hewes, David L Deitcher and Edwin S Levitan
Nature Neuroscience 8, 173–178
(February 2005); doi:10.1038/nn1377
| Abstract | Full Text (HTML/PDF) |
article
Cyclic AMP controls BDNF-induced TrkB phosphorylation and dendritic spine formation in mature hippocampal neurons
Yuanyuan Ji, Petti T Pang, Linyin Feng and Bai Lu
Nature Neuroscience 8, 164–172
(February 2005); doi:10.1038/nn1381
| Abstract | Full Text (HTML/PDF) |
research article
Functional annotation and network reconstruction through cross-platform integration of microarray data
Xianghong Jasmine Zhou, Ming-Chih J Kao, Haiyan Huang, Angela Wong, Juan Nunez-Iglesias, Michael Primig, Oscar M Aparicio, Caleb E Finch, Todd E Morgan and Wing Hung Wong
Nature Biotechnology 23, 238–243
(February 2005); doi:10.1038/nbt1058
| First Paragraph | Full Text (HTML/PDF) |
research article
A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design
Graeme L Card, Landy Blasdel, Bruce P England, Chao Zhang, Yoshihisa Suzuki, Sam Gillette, Daniel Fong, Prabha N Ibrahim, Dean R Artis, Gideon Bollag, Michael V Milburn, Sung-Hou Kim, Joseph Schlessinger and Kam Y J Zhang
Nature Biotechnology 23, 201–207
(February 2005); doi:10.1038/nbt1059
| Abstract | Full Text (HTML/PDF) |
news and views
A new school for screening
Harren Jhoti
Nature Biotechnology 23, 184–186
(February 2005); doi:10.1038/nbt0205-184
| Full Text (HTML/PDF) |
review article
Metabotropic glutamate receptors as novel targets for anxiety and stress disorders
Chad J. Swanson, Mark Bures, Michael P. Johnson, Anni-Maija Linden, James A. Monn and Darryle D. Schoepp
Nature Reviews Drug Discovery 4, 131–144
(February 2005); doi:10.1038/nrd1630
| Summary | Full Text (HTML / PDF) |
article
Specific and potent RNAi in the nucleus of human cells
G Brett Robb, Kirk M Brown, Jaspreet Khurana and Tariq M Rana
Nature Structural and Molecular Biology 12, 133–137
(February 2005); doi:10.1038/nsmb886
| Abstract | Full Text (HTML/PDF) |
research article
Gene identification signature (GIS) analysis for transcriptome characterization and genome annotation
Patrick Ng, Chia-Lin Wei, Wing-Kin Sung, Kuo Ping Chiu, Leonard Lipovich, Chin Chin Ang, Sanjay Gupta, Atif Shahab, Azmi Ridwan, Chee Hong Wong, Edison T Liu and Yijun Ruan
Nature Methods 2, 105–111
(February 2005); doi:10.1038/nmeth733
| Abstract | Full Text (HTML/PDF) |
news and views
Transcriptome PETs: A genome's best friends
Brock A Peters and Victor E Velculescu
Nature Methods 2, 93–94
(February 2005); doi:10.1038/nmeth0205-93
| Abstract | Full Text (HTML/PDF) |
review article
The humanization of N-glycosylation pathways in yeast
Stefan Wildt and Tilllman U. Gerngross
Nature Reviews Microbiology 3, 119–128
(February 2005); doi:10.1038/nrmicro1087
| Abstract | Full Text (HTML / PDF) |
article
Structural basis of actin filament nucleation and processive capping by a formin homology 2 domain
Takanori Otomo, Diana R. Tomchick, Chinatsu Otomo, Sanjay C. Panchal, Mischa Machius and Michael K. Rosen
Nature 433, 488–494
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letters to nature
CD36 is a sensor of diacylglycerides
Kasper Hoebe, Philippe Georgel, Sophie Rutschmann, Xin Du, Suzanne Mudd, Karine Crozat, Sosathya Sovath, Louis Shamel, Thomas Hartung, Ulrich Zähringer and Bruce Beutler
Nature 433, 523–527
(03 February 2005); doi:10.1038/nature03253
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letters to nature
Interaction network containing conserved and essential protein complexes in Escherichia coli
Gareth Butland, José Manuel Peregrín-Alvarez, Joyce Li, Wehong Yang, Xiaochun Yang, Veronica Canadien, Andrei Starostine, Dawn Richards, Bryan Beattie, Nevan Krogan, Michael Davey, John Parkinson , Jack Greenblatt and Andrew Emili
Nature 433, 531–537
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letters to nature
Structure and different conformational states of native AMPA receptor complexes
Terunaga Nakagawa, Yifan Cheng, Elizabeth Ramm, Morgan Sheng and Thomas Walz
Nature 433, 545–549
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Bcl-2 expression suppresses mismatch repair activity through inhibition of E2F transcriptional activity
Cha-Kyung Youn, Hyun-Ju Cho, Soo-Hyun Kim, Hong-Beum Kim, Mi-Hwa Kim, In-Youb Chang, Jung-Sup Lee, Myung-Hee Chung, Kyung-Soo Hahm and Ho Jin You
Nature Cell Biology 7, 137–147
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news and views
A mismatched role for Bcl-2
Nicholas B. La Thangue
Nature Cell Biology 7, 101–102
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TRPC1 forms the stretch-activated cation channel in vertebrate cells
Rosario Maroto, Albert Raso, Thomas G. Wood, Alex Kurosky, Boris Martinac and Owen P. Hamill
Nature Cell Biology 7, 179–185
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review article
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling
Christine Le Roy and Jeffrey L. Wrana
Nature Reviews Molecular Cell Biology 6, 112–126
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review article
Protein S-nitrosylation: purview and parameters
Douglas T. Hess, Akio Matsumoto, Sung-Oog Kim, Harvey E. Marshall and Jonathan S. Stamler
Nature Reviews Molecular Cell Biology 6, 150–166
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A leucine zipper in the N terminus confers membrane association to SLP-65
Fabian Köhler, Bettina Storch, Yogesh Kulathu, Sebastian Herzog, Stephan Kuppig, Michael Reth and Hassan Jumaa
Nature Immunology 6, 204–210
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Downregulation of lipopolysaccharide response in drosophila by negative crosstalk between the AP1 and NF-κB signaling modules
Taeil Kim, Joonsun Yoon, Hwansung Cho, Wook-bin Lee, Joon Kim, Young-Hwa Song, Se Nyun Kim, Jeong Ho Yoon, Jeongsil Kim-Ha and Young-Joon Kim
Nature Immunology 6, 211–218
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review article
Mast cells in the development of adaptive immune responses
Stephen J Galli, Susumu Nakae and Mindy Tsai
Nature Immunology 6, 135–142
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review article
The tetraspanin web modulates immune-signalling complexes
Shoshana Levy and Tsipi Shoham
Nature Reviews Immunology 5, 136–148
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perspectives
Innovation: Control of DNA replication and its potential clinical exploitation
Michael A. Gonzalez, Kiku-e K. Tachibana, Ronald A. Laskey and Nicholas Coleman
Nature Reviews Cancer AOP published online 20 January 2005; doi:10.1038/nrc1548
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Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2
Louise A Metherell, J Paul Chapple, Sadani Cooray, Alessia David, Christian Becker, Franz Rüschendorf, Danielle Naville, Martine Begeot, Bernard Khoo, Peter Nürnberg, Angela Huebner, Michael E Cheetham and Adrian J L Clark
Nature Genetics 37, 166–170
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Comm function in commissural axon guidance: cell-autonomous sorting of Robo in vivo
Krystyna Keleman, Carlos Ribeiro and Barry J Dickson
Nature Neuroscience 8, 156–163
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Comm-ing across the midline
Catherine E Krull
Nature Neuroscience 8, 131–132
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review article
The histamine H3 receptor: from gene cloning to H3 receptor drugs
Rob Leurs, Remko A. Bakker, Henk Timmerman and Iwan J. P. de Esch
Nature Reviews Drug Discovery AOP published online 24 January 2005; doi:10.1038/nrd1631
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Surface charge and hydrophobicity determine ErbB2 binding to the Hsp90 chaperone complex
Wanping Xu, Xitong Yuan, Zhexin Xiang, Edward Mimnaugh, Monica Marcu and Len Neckers
Nature Structural and Molecular Biology 12, 120–126
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Site-specific labeling of cell surface proteins with biophysical probes using biotin ligase
Irwin Chen, Mark Howarth, Weiying Lin & Alice Y Ting
Nature Methods 2, 99–104
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