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Research library: browse by date

March 2005

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The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.

Click here for free access to the 'Featured Articles' section, with new articles every week.

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letters to nature
Leptin regulation of bone resorption by the sympathetic nervous system and CART
Florent Elefteriou , Jong Deok Ahn, Shu Takeda , Michael Starbuck, Xiangli Yang, Xiuyun Liu, Hisataka Kondo, William G. Richards, Tony W. Bannon, Masaki Noda, Karine Clement, Christian Vaisse and Gerard Karsenty
Nature 434, 514–520
(24 March 2005); doi:10.1038/nature03398
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news and views
Physiology: Do neural signals remodel bone?
Joel K. Elmquist and Gordon J. Strewler
Nature 434, 447–448
(24 March 2005); doi:10.1038/434447a
| Full Text (HTML / PDF) |

letters to nature
Recognition of bacterial glycosphingolipids by natural killer T cells
Yuki Kinjo, Douglass Wu, Gisen Kim, Guo-Wen Xing, Michael A. Poles, David D. Ho, Moriya Tsuji, Kazuyoshi Kawahara, Chi-Huey Wong and Mitchell Kronenberg
Nature 434, 520–525
(24 March 2005); doi:10.1038/nature03407
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letters to nature
Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections
Jochen Mattner, Kristin L. DeBord, Nahed Ismail, Randal D. Goff, Carlos Cantu III, Dapeng Zhou, Pierre Saint-Mezard, Vivien Wang, Ying Gao, Ning Yin, Kasper Hoebe, Olaf Schneewind, David Walker, Bruce Beutler, Luc Teyton, Paul B. Savage and Albert Bendelac
Nature 434, 525–529
(24 March 2005); doi:10.1038/nature03408
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letters to nature
Fission yeast Mes1p ensures the onset of meiosis II by blocking degradation of cyclin Cdc13p
Daisuke Izawa, Masuo Goto, Akira Yamashita, Hiroyuki Yamano and Masayuki Yamamoto
Nature 434, 529–533
(24 March 2005); doi:10.1038/nature03406
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letters to nature
Recruitment of Drosophila Polycomb group proteins to chromatin by DSP1
Jérôme Déjardin, Aurélien Rappailles, Olivier Cuvier, Charlotte Grimaud, Martine Decoville, Daniel Locker and Giacomo Cavalli
Nature 434, 533–538
(24 March 2005); doi:10.1038/nature03386
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article
Functionally distinct kinesin-13 family members cooperate to regulate microtubule dynamics during interphase
Vito Mennella, Gregory C. Rogers, Stephen L. Rogers, Daniel W. Buster, Ronald D. Vale and David J. Sharp
Nature Cell Biology 7, 235–245
(March 2005); doi:10.1038/ncb1222
| Abstract | Full Text (HTML/PDF) |

letter
Atrophy of S6K1−/− skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control
Mickaël Ohanna, Andrew K. Sobering, Thomas Lapointe, Lazaro Lorenzo, Christophe Praud, Emmanuel Petroulakis, Nahum Sonenberg, Paul A. Kelly, Athanassia Sotiropoulos and Mario Pende
Nature Cell Biology 7, 286–294
(March 2005); doi:10.1038/ncb1231
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review article
The mitochondrial uncoupling-protein homologues
Stefan Krauss, Chen-Yu Zhang and Bradford B. Lowell
Nature Reviews Molecular Cell Biology 6, 248–261
(March 2005); doi:10.1038/nrm1592
| Summary | Full Text (HTML / PDF) |

article
A cytosolic pathway for MHC class II-restricted antigen processing that is proteasome and TAP dependent
Mona K Tewari, Gomathinayagam Sinnathamby, Deepa Rajagopal and Laurence C Eisenlohr
Nature Immunology 6, 287–294
(March 2005); doi:10.1038/ni1171
| Abstract | Full Text (HTML/PDF) |

article
G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes
Mutsuo Harada, Yingjie Qin, Hiroyuki Takano, Tohru Minamino, Yunzeng Zou, Haruhiro Toko, Masashi Ohtsuka, Katsuhisa Matsuura, Masanori Sano, Jun-ichiro Nishi, Koji Iwanaga, Hiroshi Akazawa, Takeshige Kunieda, Weidong Zhu, Hiroshi Hasegawa, Keita Kunisada, Toshio Nagai, Haruaki Nakaya, Keiko Yamauchi-Takihara and Issei Komuro
Nature Medicine 11, 305–311
(March 2005); doi:10.1038/nm1199
| Abstract | Full Text (HTML/PDF) |

article
Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy
Alexander J Muller, James B DuHadaway, P Scott Donover, Erika Sutanto-Ward and George C Prendergast
Nature Medicine 11, 312–319
(March 2005); doi:10.1038/nm1196
| Abstract | Full Text (HTML/PDF) |

review article
Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia
Ruibao Ren
Nature Reviews Cancer 5, 172–183
(March 2005); doi:10.1038/nrc1567
| Summary | Full Text (HTML / PDF) |

article
Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing
Harikrishnan K N, Maggie Z Chow, Emma K Baker, Sharmistha Pal, Sahar Bassal, Daniella Brasacchio, Li Wang, Jeff M Craig, Peter L Jones, Saïd Sif and Assam El-Osta
Nature Genetics 37, 254–264
(March 2005); doi:10.1038/ng1516
| Abstract | Full Text (HTML/PDF) |

news and views
SWItching off methylated DNA
Paul A Wade
Nature Genetics 37, 212–213
(March 2005); doi:10.1038/ng0305-212
| Full Text (HTML/PDF) |

article
Directed differentiation of telencephalic precursors from embryonic stem cells
Kiichi Watanabe, Daisuke Kamiya, Ayaka Nishiyama, Tomoko Katayama, Satoshi Nozaki, Hiroshi Kawasaki, Yasuyoshi Watanabe, Kenji Mizuseki and Yoshiki Sasai
Nature Neuroscience 8, 288–296
(March 2005); doi:10.1038/nn1402
| Abstract | Full Text (HTML/PDF) |

review article
The floor plate: multiple cells, multiple signals
Marysia Placzek and James Briscoe
Nature Reviews Neuroscience 6, 230–240
(March 2005); doi:10.1038/nrn1628
| Summary | Full Text (HTML / PDF) |

research article
Evolutionary optimization of fluorescent proteins for intracellular FRET
Annalee W Nguyen and Patrick S Daugherty
Nature Biotechnology 23, 355–360
(March 2005); doi:10.1038/nbt1066
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news and views
Some assembly required
Mark L Mayer
Nature Structural and Molecular Biology 12, 208–209
(March 2005); doi:10.1038/nsmb0305-208
| Full Text (HTML/PDF) |

news and views
Rings around kinetochore microtubules in yeast
J Richard McIntosh
Nature Structural and Molecular Biology 12, 210–212
(March 2005); doi:10.1038/nsmb0305-210
| Full Text (HTML/PDF) |

research article
Protein photo-cross-linking in mammalian cells by site-specific incorporation of a photoreactive amino acid
Nobumasa Hino, Yuko Okazaki, Takatsugu Kobayashi, Akiko Hayashi, Kensaku Sakamoto and Shigeyuki Yokoyama
Nature Methods 2, 201–206
(March 2005); doi:10.1038/nmeth739
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review article
Poxvirus tropism
Grant McFadden
Nature Reviews Microbiology 3, 201–213
(March 2005); doi:10.1038/nrmicro1099
| Summary | Full Text (HTML / PDF) |

letters to nature
The MET oncogene drives a genetic programme linking cancer to haemostasis
Carla Boccaccio, Gabriella Sabatino, Enzo Medico, Flavia Girolami, Antonia Follenzi, Gigliola Reato, Antonino Sottile, Luigi Naldini and Paolo M. Comoglio
Nature 434, 396–400
(17 March 2005); doi:10.1038/nature03357
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letters to nature
The vacuolar Ca2+-activated channel TPC1 regulates germination and stomatal movement
Edgar Peiter, Frans J. M. Maathuis, Lewis N. Mills, Heather Knight, Jérôme Pelloux, Alistair M. Hetherington and Dale Sanders
Nature 434, 404–408
(17 March 2005); doi:10.1038/nature03381
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letter
Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development
Savraj S. Grewal, Ling Li, Amir Orian, Robert N. Eisenman and Bruce A. Edgar
Nature Cell Biology 7, 295–302
(March 2005); doi:10.1038/ncb1223
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letter
c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription
Azadeh Arabi, Siqin Wu, Karin Ridderstråle, Holger Bierhoff, Chiounan Shiue, Karoly Fatyol, Sara Fahlén, Per Hydbring, Ola Söderberg, Ingrid Grummt, Lars-Gunnar Larsson and Anthony P. H. Wright
Nature Cell Biology 7, 303–310
(March 2005); doi:10.1038/ncb1225
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letter
c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I
Carla Grandori, Natividad Gomez-Roman, Zoe A. Felton-Edkins, Celine Ngouenet, Denise A. Galloway, Robert N. Eisenman and Robert J. White
Nature Cell Biology 7, 311–318
(March 2005); doi:10.1038/ncb1224
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news and views
The Myc trilogy: lord of RNA polymerases
Thordur Oskarsson and Andreas Trumpp
Nature Cell Biology 7, 215–217
(March 2005); doi:10.1038/ncb0305-215
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review article
Organization of vesicular trafficking in epithelia
Enrique Rodriguez-Boulan, Geri Kreitzer and Anne Müsch
Nature Reviews Molecular Cell Biology 6, 233–247
(March 2005); doi:10.1038/nrm1593
| Summary | Full Text (HTML / PDF) |

article
Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase
Catherine van Vliet, Patricia E Bukczynska, Michelle A Puryer, Christine M Sadek, Benjamin J Shields, Michel L Tremblay and Tony Tiganis
Nature Immunology 6, 253–260
(March 2005); doi:10.1038/ni1169
| Abstract | Full Text (HTML/PDF) |

article
Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4
Hans Christian Probst, Kathy McCoy, Taku Okazaki, Tasuku Honjo and Maries van den Broek
Nature Immunology 6, 280–286
(March 2005); doi:10.1038/ni1165
| Abstract | Full Text (HTML/PDF) |

news and views
Dendritic cells giveth and taketh away
Abul K Abbas and Arlene H Sharpe
Nature Immunology 6, 227–228
(March 2005); doi:10.1038/ni0305-227
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review article
Regulation of plasma-cell development
Miriam Shapiro-Shelef and Kathryn Calame
Nature Reviews Immunology 5, 230–242
(March 2005); doi:10.1038/nri1572
| Summary | Full Text (HTML / PDF) |

article
The fibrin-derived peptide Bβ15-42 protects the myocardium against ischemia-reperfusion injury
Peter Petzelbauer, Paula A Zacharowski, Yasuhiro Miyazaki, Peter Friedl, Georg Wickenhauser, Francis J Castellino, Marion Gröger, Klaus Wolff and Kai Zacharowski
Nature Medicine 11, 298–304
(March 2005); doi:10.1038/nm1198
| Abstract | Full Text (HTML/PDF) |

letter
Conservation and diversification of Wnt signaling function during the evolution of nematode vulva development
Min Zheng, Daniel Messerschmidt, Benno Jungblut and Ralf J Sommer
Nature Genetics 37, 300–304
(March 2005); doi:10.1038/ng1512
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article
Histone deacetylase 9 couples neuronal activity to muscle chromatin acetylation and gene expression
Alexandre Méjat, Francis Ramond, Rhonda Bassel-Duby, Saadi Khochbin, Eric N Olson and Laurent Schaeffer
Nature Neuroscience 8, 313–321
(March 2005); doi:10.1038/nn1408
| Abstract | Full Text (HTML/PDF) |

review article
Molecular motors and mechanisms of directional transport in neurons
Nobutaka Hirokawa and Reiko Takemura
Nature Reviews Neuroscience 26, 201–214
(2005); doi:10.1038/nrn1624
| Summary | Full Text (HTML / PDF) |

research article
Programmable ligand-controlled riboregulators of eukaryotic gene expression
Travis S Bayer and Christina D Smolke
Nature Biotechnology 23, 337–343
(March 2005); doi:10.1038/nbt1069
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news and views
Plug-and-play with RNA
Farren J Isaacs and James J Collins
Nature Biotechnology 23, 306–307
(March 2005); doi:10.1038/nbt0305-306
| Full Text (HTML/PDF) |

article
SUMO modification of the ubiquitin-conjugating enzyme E2-25K
Andrea Pichler, Puck Knipscheer, Edith Oberhofer, Willem J van Dijk, Roman Körner, Jesper Velgaard Olsen, Stefan Jentsch, Frauke Melchior and Titia K Sixma
Nature Structural and Molecular Biology 12, 264–269
(March 2005); doi:10.1038/nsmb903
| Abstract | Full Text (HTML/PDF) |

brief communication
Stem cell proliferative history in tissue revealed by temporal halogenated thymidine analog discrimination
Christopher J Vega and Daniel A Peterson
Nature Methods 2, 167–169
(March 2005); doi:10.1038/nmeth741
| Abstract | Full Text (HTML/PDF) |

article
Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells
Ren-He Xu, Ruthann M Peck, Dong S Li, Xuezhu Feng, Tenneille Ludwig and James A Thomson
Nature Methods 2, 185–190
(March 2005); doi:10.1038/nmeth744
| Abstract | Full Text (HTML/PDF) |

news and views
Stem cell culture, one step at a time
Martin F Pera
Nature Methods 2, 164–165
(March 2005); doi:10.1038/nmeth0305-164
| Abstract | Full Text (HTML/PDF) |

news and views
Global conformational rearrangements during the activation of the GDP/GTP exchange factor Vav3
Óscar Llorca, Ernesto Arias-Palomo, José L Zugaza and Xosé R Bustelo
EMBO Journal AOP,
(10 March 2005); doi:10.1038/sj.emboj.7600617
| Abstract | Full Text (HTML/PDF) |

letters to nature
Spatial bistability of Dpp-receptor interactions during Drosophila dorsal-ventral patterning
Yu-Chiun Wang and Edwin L. Ferguson
Nature 434, 229–234
(10 March 2005); doi:10.1038/nature03318
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letters to nature
Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity
Michelle Krogsgaard, Qi-jing Li, Cenk Sumen, Johannes B. Huppa, Morgan Huse and Mark M. Davis
Nature 434, 238–243
(10 March 2005); doi:10.1038/nature03391
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letters to nature
Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors
Akinori Takaoka, Hideyuki Yanai, Seiji Kondo, Gordon Duncan, Hideo Negishi, Tatsuaki Mizutani, Shin-ichi Kano, Kenya Honda, Yusuke Ohba, Tak W. Mak and Tadatsugu Taniguchi
Nature 434, 243–249
(10 March 2005); doi:10.1038/nature03308
| First Paragraph | Full Text (HTML / PDF) |

letter
Par-3 controls tight junction assembly through the Rac exchange factor Tiam1
Xinyu Chen and Ian G. Macara
Nature Cell Biology 7, 262–269
(March 2005); doi:10.1038/ncb1226
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letter
PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1
Takashi Nishimura, Tomoya Yamaguchi, Katsuhiro Kato, Masato Yoshizawa, Yo-ichi Nabeshima, Shigeo Ohno, Mikio Hoshino and Kozo Kaibuchi
Nature Cell Biology 7, 270–277
(March 2005); doi:10.1038/ncb1227
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news and views
Pars and polarity: taking control of Rac
Toby W. Hurd and Ben Margolis
Nature Cell Biology 7, 205–207
(March 2005); doi:10.1038/ncb0305-205
| Full Text (HTML/PDF) |

review article
Lipid traffic: floppy drives and a superhighway
Joost C. M. Holthuis and Tim P. Levine
Nature Reviews Molecular Cell Biology 6, 209–220
(March 2005); doi:10.1038/nrm1591
| Summary | Full Text (HTML / PDF) |

article
STAT5 regulates the self-renewal capacity and differentiation of human memory B cells and controls Bcl-6 expression
Ferenc A Scheeren, Marianne Naspetti, Sean Diehl, Remko Schotte, Maho Nagasawa, Erwin Wijnands, Ramon Gimeno, Florry A Vyth-Dreese, Bianca Blom and Hergen Spits
Nature Immunology 6, 303–313
(March 2005); doi:10.1038/ni1172
| Abstract | Full Text (HTML/PDF) |

review article
MHC class I molecules and kirs in human history, health and survival
Peter Parham
Nature Reviews Immunology 5, 201–214
(March 2005); doi:10.1038/nri1570
| Summary | Full Text (HTML / PDF) |

article
Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy
Hiromu Ito, Mette Koefoed, Prarop Tiyapatanaputi, Kirill Gromov, J Jeffrey Goater, Jonathan Carmouche, Xinping Zhang, Paul T Rubery, Joseph Rabinowitz, R Jude Samulski, Takashi Nakamura, Kjeld Soballe, Regis J O'Keefe, Brendan F Boyce and Edward M Schwarz
Nature Medicine 11, 291–297
(March 2005); doi:10.1038/nm1190
| Abstract | Full Text (HTML/PDF) |

article
Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'
Leonid Bystrykh, Ellen Weersing, Bert Dontje, Sue Sutton, Mathew T Pletcher, Tim Wiltshire, Andrew I Su, Edo Vellenga, Jintao Wang, Kenneth F Manly, Lu Lu, Elissa J Chesler, Rudi Alberts, Ritsert C Jansen, Robert W Williams, Michael P Cooke and Gerald de Haan
Nature Genetics 37, 225–232
(March 2005); doi:10.1038/ng1497
| Abstract | Full Text (HTML/PDF) |

news and views
Mapping expression in randomized rodent genomes
Karl W Broman
Nature Genetics 37, 209–210
(March 2005); doi:10.1038/ng0305-209
| Full Text (HTML/PDF) |

letter
Nephrocystin-5, a ciliary IQ domain protein, is mutated in Senior-Loken syndrome and interacts with RPGR and calmodulin
Edgar A Otto, Bart Loeys, Hemant Khanna, Jan Hellemans, Ralf Sudbrak, Shuling Fan, Ulla Muerb, John F O'Toole, Juliana Helou, Massimo Attanasio, Boris Utsch, John A Sayer, Concepcion Lillo, David Jimeno, Paul Coucke, Anne De Paepe, Richard Reinhardt, Sven Klages, Motoyuki Tsuda, Isao Kawakami, Takehiro Kusakabe, Heymut Omran, Anita Imm, Melissa Tippens, Pamela A Raymond, Jo Hill, Phil Beales, Shirley He, Andreas Kispert, Benjamin Margolis, David S Williams, Anand Swaroop and Friedhelm Hildebrandt
Nature Genetics 37, 282–288
(March 2005); doi:10.1038/ng1520
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article
Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification
Scott Pegan, Christine Arrabit, Wei Zhou, Witek Kwiatkowski, Anthony Collins, Paul A Slesinger and Senyon Choe
Nature Neuroscience 8, 279–287
(March 2005); doi:10.1038/nn1411
| Abstract | Full Text (HTML/PDF) |

article
Soluble CPG15 expressed during early development rescues cortical progenitors from apoptosis
Ulrich Putz, Corey Harwell and Elly Nedivi
Nature Neuroscience 8, 322–331
(March 2005); doi:10.1038/nn1407
| Abstract | Full Text (HTML/PDF) |

review article
Variations on an inhibitory theme: phasic and tonic activation of GABAA receptors
Mark Farrant and Zoltan Nusser
Nature Reviews Neuroscience 6, 215–229
(March 2005); doi:10.1038/nrn1625
| Summary | Full Text (HTML / PDF) |

review article
HDL as a target in the treatment of atherosclerotic cardiovascular disease
Patrick Linsel-Nitschke and Alan R. Tall
Nature Reviews Drug Discovery 4, 193–205
(March 2005); doi:10.1038/nrd1658
| Summary | Full Text (HTML / PDF) |

article
Nucleotide-dependent substrate recognition by the AAA+ HslUV protease
Randall E Burton, Tania A Baker and Robert T Sauer
Nature Structural and Molecular Biology 12, 245–251
(March 2005); doi:10.1038/nsmb898
| Abstract | Full Text (HTML/PDF) |

article
A FlAsH-based FRET approach to determine G protein-coupled receptor activation in living cells
Carsten Hoffmann, Guido Gaietta, Moritz Bünemann, Stephen R Adams, Silke Oberdorff-Maass, Björn Behr, Jean-Pierre Vilardaga, Roger Y Tsien, Mark H Ellisman and Martin J Lohse
Nature Methods 2, 171–176
(2005); doi:10.1038/nmeth742
| Abstract | Full Text (HTML/PDF) |

article
Real-time monitoring of receptor and G-protein interactions in living cells
Céline Galés, R Victor Rebois, Mireille Hogue, Phan Trieu, Andreas Breit, Terence E Hébert, 3 and Michel Bouvier
Nature Methods 2, 177–184
(March 2005); doi:10.1038/nmeth743
| Abstract | Full Text (HTML/PDF) |

news and views
New eyes to see texture in ligand efficacy
Terry P Kenakin
Nature Methods 2, 163–164
(March 2005); doi:10.1038/nmeth0305-163
| Abstract | Full Text (HTML/PDF) |

article
Bcr-Abl-mediated suppression of normal hematopoiesis in leukemia
Randall E Burton, Tania A Baker and Robert T Sauer
Oncogene
(AOP 28 February 2005); doi:10.1038/c
| Abstract | Full Text (HTML/PDF) |

letters to nature
Cross-presentation by intercellular peptide transfer through gap junctions
Joost Neijssen, Carla Herberts, Jan Wouter Drijfhout, Eric Reits, Lennert Janssen and Jacques Neefjes
Nature 434, 83–88
(03 March 2005); doi:10.1038/nature03290
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news and views
Coupling and cross-presentation
William R. Heath and Francis R. Carbone
Nature 434, 27–28
(03 March 2005); doi:10.1038/434027a
| Full Text (HTML / PDF) |

letters to nature
CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death
Edith M. Janssen, Nathalie M. Droin, Edward E. Lemmens, Michael J. Pinkoski, Steven J. Bensinger, Benjamin D. Ehst, Thomas S. Griffith, Douglas R. Green and Stephen P. Schoenberger
Nature 434, 88–93
(03 March 2005); doi:10.1038/nature03337
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letters to nature
Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans
Jason M. Kinchen , Juan Cabello, Doris Klingele, Kelvin Wong, Richard Feichtinger, Heinke Schnabel, Ralf Schnabel and Michael O. Hengartner
Nature 434, 93–99
(03 March 2005); doi:10.1038/nature03263
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letters to nature
Phospholipase Cγ1 controls surface expression of TRPC3 through an intermolecular PH domain
Damian B. van Rossum, Randen L. Patterson, Sumit Sharma, Roxanne K. Barrow, Michael Kornberg, Donald L. Gill and Solomon H. Snyder
Nature 434, 99–104
(03 March 2005); doi:10.1038/nature03340
| First Paragraph | Full Text (HTML / PDF) |

letters to nature
Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates
Mart Loog and David O. Morgan
Nature 434, 104–108
(03 March 2005); doi:10.1038/nature03329
| First Paragraph | Full Text (HTML / PDF) |

news and views
Cell cycle: Cyclin guides the way
Curt Wittenberg
Nature 434, 34–35
(03 March 2005); doi:10.1038/434034a
| Full Text (HTML / PDF) |

letters to nature
Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1
Sherif F. El-Khamisy, Gulam M. Saifi, Michael Weinfeld, Fredrik Johansson, Thomas Helleday, James R. Lupski and Keith W. Caldecott
Nature 434, 108–113
(03 March 2005); doi:10.1038/nature03314
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letters to nature
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
Joseph T. Rodgers, Carlos Lerin, Wilhelm Haas, Steven P. Gygi, Bruce M. Spiegelman and Pere Puigserver
Nature 434, 113–118
(03 March 2005); doi:10.1038/nature03354
| First Paragraph | Full Text (HTML / PDF) |

letter
Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion
Simon Wilkinson, Hugh F. Paterson and Christopher J. Marshall
Nature Cell Biology 7, 255–261
(March 2005); doi:10.1038/ncb1230
| First Paragraph | Full Text (HTML/PDF) |

news and views
Cdc48-Ufd2-Rad23: the road less ubiquitinated?
Omar A. Bazirgan and Randolph Y. Hampton
Nature Cell Biology 7, 207–209
(March 2005); doi:10.1038/ncb0305-207
| Full Text (HTML/PDF) |

perspectives
Spindle assembly: asters part their separate ways
Jody Rosenblatt
Nature Cell Biology 7, 219–222
(March 2005); doi:10.1038/ncb0305-219
| Abstract | Full Text (HTML/PDF) |

review article
Intrinsically unstructured proteins and their functions
H. Jane Dyson and Peter E. Wright
Nature Reviews Molecular Cell Biology 6, 197–208
(March 2005); doi:10.1038/nrm1589
| Summary | Full Text (HTML / PDF) |

article
Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse
Timothy S Gomez, Michael J Hamann, Sean McCarney, Doris N Savoy, Casey M Lubking, Michael P Heldebrant, Christine M Labno, David J McKean, Mark A McNiven, Janis K Burkhardt and Daniel D Billadeau
Nature Immunology 6, 261–270
(March 2005); doi:10.1038/ni1168
| Abstract | Full Text (HTML/PDF) |

review article
The role of BH3-only proteins in the immune system
Andreas Strasser
Nature Reviews Immunology 5, 189–200
(March 2005); doi:10.1038/nri1568
| Summary | Full Text (HTML / PDF) |

article
Sequence-specific potent induction of IFN-α by short interfering RNA in plasmacytoid dendritic cells through TLR7
Veit Hornung, Margit Guenthner-Biller, Carole Bourquin, Andrea Ablasser, Martin Schlee, Satoshi Uematsu, Anne Noronha, Muthiah Manoharan, Shizuo Akira, Antonin de Fougerolles, Stefan Endres and Gunther Hartmann
Nature Medicine 11, 263–270
(March 2005); doi:10.1038/nm1191
| Abstract | Full Text (HTML/PDF) |

news and views
Sensing the danger in RNA
Marjorie A Robbins and John J Rossi
Nature Medicine 11, 250–251
(March 2005); doi:10.1038/nm0305-250
| Full Text (HTML/PDF) |

article
Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis
Melanie Greter, Frank L Heppner, Maria P Lemos, Bernhard M Odermatt, Norbert Goebels, Terri Laufer, Randolph J Noelle and Burkhard Becher
Nature Medicine 11, 328–334
(March 2005); doi:10.1038/nm1197
| Abstract | Full Text (HTML/PDF) |

letter
Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis
Eileen J McMahon, Samantha L Bailey, Carol Vanderlugt Castenada, Hanspeter Waldner and Stephen D Miller
Nature Medicine 11, 335–339
(March 2005); doi:10.1038/nm1202
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news and views
Multiple sclerosis: trapped in deadly glue
Michael Platten and Lawrence Steinman
Nature Medicine 11, 252–253
(March 2005); doi:10.1038/nm0305-252
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letter
A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2
Bart L Loeys, Junji Chen, Enid R Neptune, Daniel P Judge, Megan Podowski, Tammy Holm, Jennifer Meyers, Carmen C Leitch, Nicholas Katsanis, Neda Sharifi, F Lauren Xu, Loretha A Myers, Philip J Spevak, Duke E Cameron, Julie De Backer, Jan Hellemans, Yan Chen, Elaine C Davis, Catherine L Webb, Wolfram Kress, Paul Coucke, Daniel B Rifkin, Anne M De Paepe and Harry C Dietz
Nature Genetics 37, 275–281
(March 2005); doi:10.1038/ng1511
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technical report
MAGIC, an in vivo genetic method for the rapid construction of recombinant DNA molecules
Mamie Z Li and Stephen J Elledge
Nature Genetics 37, 311–319
(March 2005); doi:10.1038/ng1505
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review article
The centrosome in human genetic disease
Jose L. Badano, Tanya M. Teslovich and Nicholas Katsanis
Nature Reviews Genetics 6, 194–205
(March 2005); doi:10.1038/nrg1557
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review article
Expression and functions of neuronal gap junctions
Goran Söhl, Stephan Maxeiner and Klaus Willecke
Nature Reviews Neuroscience 6, 191–200
(March 2005); doi:10.1038/nrn1627
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article
Actin and hnRNP U cooperate for productive transcription by RNA polymerase II
Alexander Kukalev, Ylva Nord, Carina Palmberg, Tomas Bergman and Piergiorgio Percipalle
Nature Structural and Molecular Biology 12, 238–244
(March 2005); doi:10.1038/nsmb904
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article
A new method for C-terminal sequence analysis in the proteomic era
Bart Samyn, Kjell Sergeant, Pedro Castanheira, Carlos Faro and Jozef Van Beeumen
Nature Methods 2, 193–200
(March 2005); doi:10.1038/nmeth738
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review article
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
Kim A. Brogden
Nature Reviews Microbiology 3, 238–250
(March 2005); doi:10.1038/nrmicro1098
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