The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.
Click here for free access to the 'Featured Articles' section, with new articles every week.
letters to nature IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation
Toby Lawrence , Magali Bebien, George Y. Liu, Victor Nizet and Michael Karin Nature434, 1138–1143
(28 April 2005); doi:10.1038/nature03491
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letters to nature A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
Chloé James, Valérie Ugo, Jean-Pierre Le Couédic, Judith Staerk, François Delhommeau, Catherine Lacout, Loïc Garçon, Hana Raslova, Roland Berger, Annelise Bennaceur-Griscelli, Jean Luc Villeval, Stefan N.Constantinescu, Nicole Casadevall and William Vainchenker Nature434, 1144–1148
(28 April 2005); doi:10.1038/nature03546
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letters to nature Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells Qingsheng Li, Lijie Duan, Jacob D.Estes, Zhong-Min Ma, Tracy Rourke, Yichuan Wang, Cavan Reilly, John Carlis, Christopher J.Miller and Ashley T.Haase Nature434, 1148–1152
(28 April 2005); doi:10.1038/nature03513
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letters to nature Clathrin is required for the function of the mitotic spindle
Stephen J. Royle, Nicholas A. Bright and Leon Lagnado Nature434, 1152–1157
(28 April 2005); doi:10.1038/nature03502
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article An α4 integrin-paxillin-Arf-GAP complex restricts Rac activation to the leading edge of migrating cells
Naoyuki Nishiya, William B. Kiosses, Jaewon Han and Mark H. Ginsberg Nature Cell Biology7, 343–352
(April 2005); doi:10.1038/ncb1234
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news and views Cell polarization mechanisms during directed cell migration
Anna Huttenlocher Nature Cell Biology7, 336–337
(April 2005); doi:10.1038/ncb0405-336
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letter CSN facilitates Cullin-RING ubiquitin ligase function by counteracting autocatalytic adapter instability
Susan Wee, Rory K. Geyer, Takashi Toda and Dieter A. Wolf Nature Cell Biology7, 387–391
(April 2005); doi:10.1038/ncb1241
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letter Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors
Xinhua Wang, Weizhong Zeng, Abigail A. Soyombo, Wei Tang, Elliott M. Ross, Anthony P. Barnes, Sharon L. Milgram, Josef M. Penninger, Patrick B. Allen, Paul Greengard and Shmuel Muallem Nature Cell Biology7, 405–411
(April 2005); doi:10.1038/ncb1237
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review article Calorie restriction, sirt1 and metabolism: understanding longevity
Laura Bordone and Leonard Guarente Nature Reviews Molecular Cell Biology6, 298–305
(April 2005); doi:10.1038/nrm1616
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article Immune activation modulates hematopoiesis through interactions between CD27 and CD70
Martijn A Nolte, Ramon Arens, Ronald van Os, Michiel van Oosterwijk, Berend Hooibrink, René A W van Lier and Marinus H J van Oers Nature Immunology6, 412–418
(April 2005); doi:10.1038/ni1174
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review article Natural regulatory T cells in infectious disease
Yasmine Belkaid and Barry T Rouse Nature Immunology6, 353–360
(April 2005); doi:10.1038/ni1181
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review article Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self
Shimon Sakaguchi Nature Immunology6, 345–352
(April 2005); doi:10.1038/ni1178
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review article TEC-family kinases: regulators of T-helper-cell differentiation
Pamela L. Schwartzberg, Lisa D. Finkelstein and Julie A. Readinger Nature Reviews Immunology5, 284–295
(April 2005); doi:10.1038/nri1591
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article The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis
Teiji Wada, Tomoki Nakashima, Antonio J Oliveira-dos-Santos, Juerg Gasser, Hiromitsu Hara, Georg Schett and Josef M Penninger Nature Medicine11, 394–399
(April 2005); doi:10.1038/nm1203
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review article Nuclear factor-κB inhibitors as sensitizers to anticancer drugs
Chikashi Nakanishi and Masakazu Toi Nature Reviews Cancer5, 297–309
(April 2005); doi:10.1038/nrc1588
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letter Chfr is required for tumor suppression and Aurora A regulation
Xiaochun Yu, Katherine Minter-Dykhouse, Liviu Malureanu, Wei-Meng Zhao, Dongwei Zhang, Carolin J Merkle, Irene M Ward, Hideyuki Saya, Guowei Fang, Jan van Deursen and Junjie Chen Nature Genetics37, 401–406
(April 2005); doi:10.1038/ng1538
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research article Enrichment and analysis of peptide subsets using fluorous affinity tags and mass spectrometry
Scott M Brittain, Scott B Ficarro, Ansgar Brock and Eric C Peters Nature Biotechnology23, 463–468
(April 2005); doi:10.1038/nbt1076
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review article Model organisms: Chemistry-to-gene screens in Caenorhabditis elegans
Andrew K. Jones, Steven D. Buckingham and David B. Sattelle Nature Reviews Drug Discovery4, 321–330
(April 2005); doi:10.1038/nrd1692
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article Essential role for the second extracellular loop in C5a receptor activation
Jeffery M Klco, Christina B Wiegand, Kirk Narzinski and Thomas J Baranski Nature Structural and Molecular Biology12, 320–326
(April 2005); doi:10.1038/nsmb913
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news and views The second extracellular loop: a damper for G protein-coupled receptors?
Dominique Massotte and Brigitte L Kieffer Nature Structural and Molecular Biology12, 287–288
(April 2005); doi:10.1038/nsmb0405-287
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article In vivo protein biotinylation for identification of organ-specific antigens accessible from the vasculature
Jascha-N Rybak, Anna Ettorre, Brigitte Kaissling, Raffaella Giavazzi, Dario Neri and Giuliano Elia Nature Methods2, 291–298
(April 2005); doi:10.1038/nmeth745
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article Molecular mechanisms of kinetochore capture by spindle microtubules
Kozo Tanaka, Naomi Mukae, Hilary Dewar, Mark van Breugel, Euan K. James, Alan R. Prescott, Claude Antony and Tomoyuki U. Tanaka Nature434, 987–994
(21 April 2005); doi:10.1038/nature03483
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letters to nature Regulation of axon growth in vivo by activity-based competition
Jackie Yuanyuan Hua, Matthew C. Smear, Herwig Baier and Stephen J. Smith Nature434, 1022–1026
(21 April 2005); doi:10.1038/nature03409
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news and views Neurobiology: Sculpted by competition
Ole Petter Ottersen Nature434, 969
(21 April 2005); doi:10.1038/434969a
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letters to nature Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction
Kenya Honda, Yusuke Ohba, Hideyuki Yanai, Hideo Negishi, Tatsuaki Mizutani, Akinori Takaoka, Choji Taya and Tadatsugu Taniguchi Nature434, 1035–1040
(21 April 2005); doi:10.1038/nature03547
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letters to nature Visualizing the mechanical activation of Src
Yingxiao Wang, Elliot L. Botvinick, Yihua Zhao, Michael W. Berns , Shunichi Usami, Roger Y. Tsien and Shu Chien Nature434, 1040–1045
(21 April 2005); doi:10.1038/nature03469
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article Prediction and validation of the distinct dynamics of transient and sustained ERK activation
Satoru Sasagawa, Yu-ichi Ozaki, Kazuhiro Fujita and Shinya Kuroda Nature Cell Biology7, 365–373
(April 2005); doi:10.1038/ncb1233
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news and views Directing NGF's actions: it's a Rap
Philip J. S. Stork Nature Cell Biology7, 338–339
(April 2005); doi:10.1038/ncb0405-338
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letter Wnt signalling induces maturation of Paneth cells in intestinal crypts
Johan H. van Es, Philippe Jay, Alex Gregorieff, Marielle E. van Gijn, Suzanne Jonkheer, Pantelis Hatzis, Andrea Thiele, Maaike van den Born, Harry Begthel, Thomas Brabletz, Makoto M. Taketo and Hans Clevers Nature Cell Biology7, 381–386
(April 2005); doi:10.1038/ncb1240
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letter Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin
Susana Gonzalo, Marta García-Cao, Mario F. Fraga, Gunnar Schotta, Antoine H.F.M. Peters, Shane E. Cotter, Raúl Eguía, Douglas C. Dean, Manel Esteller, Thomas Jenuwein and María A. Blasco Nature Cell Biology7, 420–428
(April 2005); doi:10.1038/ncb1235
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review article Translational control in stress and apoptosis
Martin Holcik and Nahum Sonenberg Nature Reviews Molecular Cell Biology6, 318–327
(April 2005); doi:10.1038/nrm1618
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article The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection
Guangping Sun, Xiaolong Liu, Peter Mercado, S Rhiannon Jenkinson, Magdalini Kypriotou, Lionel Feigenbaum, Philippe Galéra and Rémy Bosselut Nature Immunology6, 373–381
(April 2005); doi:10.1038/ni1183
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news and views Switching sides: transcriptional control of CD4 thymocyte lineage commitment
Rose Zamoyska Nature Immunology6, 363–364
(April 2005); doi:10.1038/ni0405-363
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review article Heat-shock proteins induce T-cell regulation of chronic inflammation
Willem van Eden, Ruurd van der Zee and Berent Prakken Nature Reviews Immunology5, 318–330
(April 2005); doi:10.1038/nri1593
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article Calmodulin kinase II inhibition protects against structural heart disease
Rong Zhang, Michelle S C Khoo, Yuejin Wu, Yingbo Yang, Chad E Grueter, Gemin Ni, Edward E Price, Jr. William Thiel, Silvia Guatimosim, Long-Sheng Song, Ernest C Madu, Anisha N Shah, Tatiana A Vishnivetskaya, James B Atkinson, Vsevolod V Gurevich, Guy Salama, W J Lederer, Roger J Colbran and Mark E Anderson Nature Medicine11, 409–417
(April 2005); doi:10.1038/nm1215
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news and views Beyond beta blockers
Donald M Bers Nature Medicine11, 379–380
(April 2005); doi:10.1038/nm0405-379
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news and views MET orchestrates cancer and blood coagulation
Olga I Stenina and Edward F Plow Nature Medicine11, 376–377
(April 2005); doi:10.1038/nm0405-376
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review article Immunosuppressive networks in the tumour environment and their therapeutic relevance
Weiping Zou Nature Reviews Cancer5, 263–274
(April 2005); doi:10.1038/nrc1586
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article Reverse engineering of regulatory networks in human B cells
Katia Basso, Adam A Margolin, Gustavo Stolovitzky, Ulf Klein, Riccardo Dalla-Favera and Andrea Califano Nature Genetics37, 382–390
(April 2005); doi:10.1038/ng1532
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article Drosophila N-cadherin mediates an attractive interaction between photoreceptor axons and their targets
Saurabh Prakash, Jason C Caldwell, Daniel F Eberl and Thomas R Clandinin Nature Neuroscience8, 443–450
(April 2005); doi:10.1038/nn1415
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news and views Photoreceptor axons play hide and seek
Javier Morante and Claude Desplan Nature Neuroscience8, 401–402
(April 2005); doi:10.1038/nn0405-401
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article LAR receptor protein tyrosine phosphatases in the development and maintenance of excitatory synapses
Anthone W Dunah, Emily Hueske, Michael Wyszynski, Casper C Hoogenraad, Jacek Jaworski, Daniel T Pak, Alyson Simonetta, Guosong Liu and Morgan Sheng Nature Neuroscience8, 458–467
(April 2005); doi:10.1038/nn1416
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research article Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA
Adam D Judge, Vandana Sood, Janet R Shaw, Dianne Fang, Kevin McClintock and Ian MacLachlan Nature Biotechnology23, 457–462
(April 2005); doi:10.1038/nbt1081
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review article Cellular processing of platinum anticancer drugs
Dong Wang and Stephen J. Lippard Nature Reviews Drug Discovery4, 307–320
(April 2005); doi:10.1038/nrd1691
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article The HEAT repeat protein Blm10 regulates the yeast proteasome by capping the core particle
Marion Schmidt, Wilhelm Haas, Bernat Crosas, Patricia G Santamaria, Steven P Gygi, Thomas Walz and Daniel Finley Nature Structural and Molecular Biology12, 294–303
(April 2005); doi:10.1038/nsmb914
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news and views Staufen does double duty
Erika L Meyer and Elizabeth R Gavis Nature Structural and Molecular Biology12, 291–292
(April 2005); doi:10.1038/nsmb0405-291
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brief communication In vivo protein labeling with trimethoprim conjugates: a flexible chemical tag
Lawrence W Miller, Yunfei Cai, Michael P Sheetz and Virginia W Cornish Nature methods2, 255–357
(April 2005); doi:10.1038/nmeth749
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brief communication The hESC line Envy expresses high levels of GFP in all differentiated progeny
Magdaline Costa, Mirella Dottori, Elizabeth Ng, Susan M Hawes, Koula Sourris, Pegah Jamshidi, Martin F Pera, Andrew G Elefanty and Edouard G Stanley Nature Methods2, 259–260
(April 2005); doi:10.1038/nmeth748
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review article Cell entry machines: A common theme in nature?
Michèle A. Barocchi, Vega Masignani and Rino Rappuoli Nature Reviews Microbiology3, 349–358
(April 2005); doi:10.1038/nrmicro1131
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article Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis
Edward J McManus, Kei Sakamoto, Laura J Armit, Leah Ronaldson, Natalia Shpiro, Rodolfo Marquez and Dario R Alessi The EMBO Journal24, 1571–1583
(April 2005); doi:10.1038/7600633a
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article DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
Jirina Bartkova, Zuzana Hoejí, Karen Koed, Alwin Krämer, Frederic Tort, Karsten Zieger, Per Guldberg, Maxwell Sehested, Jahn M. Nesland, Claudia Lukas, Torben Ørntoft, Jiri Lukas and Jiri Bartek Nature434, 864–870
(14 April 2005); doi:10.1038/nature03482
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news and views Medicine: Aborting the birth of cancer
Ashok R. Venkitaraman Nature434, 829–830
(14 April 2005); doi:10.1038/434829a
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letters to nature Essential role of TRPC channels in the guidance of nerve growth cones by brain-derived neurotrophic factor
Yan Li , Yi-Chang Jia , Kai Cui , Ning Li, Zai-Yu Zheng, Yi-zheng Wang and Xiao-bing Yuan Nature434, 894–898
(14 April 2005); doi:10.1038/nature03477
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letters to nature Requirement of TRPC channels in netrin-1-induced chemotropic turning of nerve growth cones
Gordon X. Wang and Mu-ming Poo Nature434, 898–904
(14 April 2005); doi:10.1038/nature03478
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news and views Neurobiology: Channels for pathfinding
Timothy Gomez Nature434, 835–838
(14 April 2005); doi:10.1038/434835a
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letters to nature Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
Helen E. Bryant, Niklas Schultz, Huw D. Thomas, Kayan M. Parker, Dan Flower, Elena Lopez, Suzanne Kyle, Mark Meuth, Nicola J. Curtin and Thomas Helleday Nature434, 913–917
(14 April 2005); doi:10.1038/nature03443
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letters to nature Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
Hannah Farmer , Nuala McCabe , Christopher J. Lord, Andrew N. J. Tutt, Damian A. Johnson, Tobias B. Richardson, Manuela Santarosa, Krystyna J. Dillon, Ian Hickson, Charlotte Knights, Niall M. B. Martin, Stephen P. Jackson, Graeme C. M. Smith and Alan Ashworth Nature434, 917–921
(14 April 2005); doi:10.1038/nature03445
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letters to nature Transcriptional regulation of a metastasis suppressor gene by Tip60 and β-catenin complexes
Jung Hwa Kim, Bogyou Kim, Ling Cai, Hee June Choi, Kenneth A. Ohgi, Chris Tran, Charlie Chen, Chin Ha Chung, Otmar Huber, David W. Rose, Charles L. Sawyers, Michael G. Rosenfeld and Sung Hee Baek Nature434, 921–926
(14 April 2005); doi:10.1038/nature03452
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letters to nature Structure of the apoptotic protease-activating factor 1 bound to ADP
Stefan J. Riedl, Wenyu Li, Yang Chao, Robert Schwarzenbacher and Yigong Shi Nature434, 926–933
(14 April 2005); doi:10.1038/nature03465
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review article Wnt signalling in stem cells and cancer
Tannishtha Reya and Hans Clevers Nature434, 843–850
(14 April 2005); doi:10.1038/nature03319
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letter Plant formin AtFH5 is an evolutionarily conserved actin nucleator involved in cytokinesis
Mathieu Ingouff, Jonathan N. Fitz Gerald, Christophe Guérin, Hélène Robert, Mikael Blom Sørensen, Daniel Van Damme, Danny Geelen, Laurent Blanchoin and Frédéric Berger Nature Cell Biology7, 374–380
(April 2005); doi:10.1038/ncb1238
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letter Stat3-induced apoptosis requires a molecular switch in PI(3)K subunit composition
Kathrine Abell, Antonio Bilancio, Richard W. E. Clarkson, Paul G. Tiffen, Anton I. Altaparmakov, Thomas G. Burdon, Tomoichiro Asano, Bart Vanhaesebroeck and Christine J. Watson Nature Cell Biology7, 392–398
(April 2005); doi:10.1038/ncb1242
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review article Developmental Cell Biology: Communicating with Hedgehogs
Joan E. Hooper and Matthew P. Scott Nature Reviews Molecular Cell Biology6, 306–317
(April 2005); doi:10.1038/nrm1612
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article Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases
Jesus M Salvador, Paul R Mittelstadt, Tad Guszczynski, Terry D Copeland, Hiroshi Yamaguchi, Ettore Appella, Albert J Fornace and Jr Jonathan D Ashwell Nature Immunology6, 390–395
(April 2005); doi:10.1038/ni1177
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article The autoimmune suppressor Gadd45α inhibits the T cell alternative p38 activation pathway
Jesus M Salvador, Paul R Mittelstadt, Galina I Belova, Albert J Fornace and Jr Jonathan D Ashwell Nature Immunology6, 396–402
(April 2005); doi:10.1038/ni1176
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news and views MAPK p38: alternative and nonstressful in T cells
Christopher E Rudd Nature Immunology6, 368–370
(April 2005); doi:10.1038/ni0405-368
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review article Mechanisms of suppression by suppressor T cells
Harald von Boehmer Nature Immunology6, 338–344
(April 2005); doi:10.1038/ni1180
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review article Dendritic cells as therapeutic vaccines against cancer
Jacques Banchereau and A. Karolina Palucka Nature Reviews Immunology5, 296–306
(April 2005); doi:10.1038/nri1592
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review article High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal
Michael T. Lotze and Kevin J. Tracey Nature Reviews Immunology5, 331–342
(April 2005); doi:10.1038/nri1594
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article Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease
Jingmei Lin, Sanjeevkumar R Patel, Xu Cheng, Eun Ah Cho, Inna Levitan, Matthew Ullenbruch, Sem H Phan, John M Park and Gregory R Dressler Nature Medicine11, 387–393
(April 2005); doi:10.1038/nm1217
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news and views Setting a trap for tissue fibrosis
Eric G Neilson Nature Medicine11, 373–374
(April 2005); doi:10.1038/nm0405-373
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news and views The shear stress of keeping arteries clear
David G Harrison Nature Medicine11, 375–376
(April 2005); doi:10.1038/nm0405-375
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review article Mechanisms of B-cell lymphoma pathogenesis
Ralf Küppers Nature Reviews Cancer5, 251–262
(April 2005); doi:10.1038/nrc1589
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article Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities
Beth A Firulli, Dayana Krawchuk, Victoria E Centonze, Neil Vargesson, David M Virshup, Simon J Conway, Peter Cserjesi, Ed Laufer and Anthony B Firulli Nature Genetics37, 373–381
(April 2005); doi:10.1038/ng1525
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article A tctex1-Ca2+ channel complex for selective surface expression of Ca2+ channels in neurons
Meizan Lai, Fushun Wang, Joyce G Rohan, Yuka Maeno-Hikichi, Yuan Chen, Yi Zhou, Guangping Gao, William A Sather and Ji-fang Zhang Nature Neuroscience8, 435–442
(April 2005); doi:10.1038/nn1418
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article Protocadherin Celsr3 is crucial in axonal tract development
Fadel Tissir, Isabelle Bar, Yves Jossin and Andre M Goffinet Nature Neuroscience8, 451–457
(April 2005); doi:10.1038/nn1428
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review article The role of calmodulin as a signal integrator for synaptic plasticity
Zhengui Xia and Daniel R. Storm Nature Reviews Neuroscience6, 267–276
(April 2005); doi:10.1038/nrn1647
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research article Extracellular secretion of polypeptides using a modified Escherichia coli flagellar secretion apparatus
Katariina Majander, Lena Anton, Jenni Antikainen, Hannu Lång, Mirko Brummer, Timo K Korhonen and Benita Westerlund-Wikström Nature Biotechnology23, 475–481
(April 2005); doi:10.1038/nbt1077
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article β-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation
Danette L Daniels and William I Weis Nature Structural and Molecular Biology12, 364–371
(April 2005); doi:10.1038/nsmb912
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article Essential Cavβ modulatory properties are AID-independent
Janet M Maltez, Deborah A Nunziato, James Kim and Geoffrey S Pitt Nature Structural and Molecular Biology12, 372–377
(April 2005); doi:10.1038/nsmb909
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article A multiplexed homogeneous fluorescence-based assay for protein kinase activity in cell lysates
Melissa D Shults, Kevin A Janes, Douglas A Lauffenburger and Barbara Imperiali Nature Methods2, 277–284
(April 2005); doi:10.1038/nmeth747
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news and views Measuring kinase activity: finding needles in a haystack
Benjamin E Turk Nature Methods2, 251–252
(April 2005); doi:10.1038/nmeth0405-251
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letters to nature Ipr1 gene mediates innate immunity to tuberculosis
Hui Pan, Bo-Shiun Yan, Mauricio Rojas , Yuriy V. Shebzukhov, Hongwei Zhou, Lester Kobzik, Darren E. Higgins, Mark J. Daly, Barry R. Bloom and Igor Kramnik Nature434, 767–772
(07 April 2005); doi:10.1038/nature03419
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news and views Tuberculosis: The genetics of vulnerability
Nada Jabado and Philippe Gros Nature434, 709–711
(07 April 2005); doi:10.1038/434709a
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letters to nature IRF-7 is the master regulator of type-I interferon-dependent immune responses
Kenya Honda, Hideyuki Yanai, Hideo Negishi, Masataka Asagiri, Mitsuharu Sato, Tatsuaki Mizutani, Naoya Shimada, Yusuke Ohba, Akinori Takaoka, Nobuaki Yoshida and Tadatsugu Taniguchi Nature434, 772–777
(07 April 2005); doi:10.1038/nature03464
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letters to nature Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption
Samira Saadoun, Marios C. Papadopoulos, Mariko Hara-Chikuma and A. S. Verkman Nature434, 786–792
(07 April 2005); doi:10.1038/nature03460
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article Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics
Thierry Dubois, Olivia Paléotti, Alexander A. Mironov, Jr Vincent Fraisier, Theresia E. B. Stradal, Maria Antonietta De Matteis, Michel Franco and Philippe Chavrier Nature Cell Biology7, 353–364
(April 2005); doi:10.1038/ncb1244
| Abstract | Full Text (HTML/PDF) |
letter Regulation of PTEN by Rho small GTPases
Zhong Li, Xiemei Dong, Zhenglong Wang, Wenzhong Liu, Ning Deng, Yu Ding, Liuya Tang, Tim Hla, Rong Zeng, Lin Li and Dianqing Wu Nature Cell Biology7, 399–404
(April 2005); doi:10.1038/ncb1236
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news and views Rho Rocks PTEN
Ruedi Meili, Atsuo T. Sasaki and Richard A. Firtel Nature Cell Biology7, 334–335
(April 2005); doi:10.1038/ncb0405-334
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letter SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions
Jordi Torres-Rosell, Félix Machín, Sarah Farmer, Adam Jarmuz, Trevor Eydmann, Jacob Z. Dalgaard and Luis Aragón Nature Cell Biology7, 412–419
(April 2005); doi:10.1038/ncb1239
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news and views The importance of being Smc5/6
Yoshinori Watanabe Nature Cell Biology7, 329–331
(April 2005); doi:10.1038/ncb0405-329
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review article IAPs, RINGs and ubiquitylation
David L. Vaux and John Silke Nature Reviews Molecular Cell Biology6, 287–297
(April 2005); doi:10.1038/nrm1621
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article The chemokine receptor D6 limits the inflammatory response in vivo
Thomas Jamieson, Donald N Cook, Robert J B Nibbs, Antal Rot, Colin Nixon, Pauline Mclean, Antonio Alcami, Sergio A Lira, Maria Wiekowski and Gerard J Graham Nature Immunology6, 403–411
(April 2005); doi:10.1038/ni1182
| Abstract | Full Text (HTML/PDF) |
news and views Inflammatory chemokines: tuned in, turned on, dropped out
Craig Gerard Nature Immunology6, 366–368
(April 2005); doi:10.1038/ni0405-366
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review article A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3
Jason D Fontenot and Alexander Y Rudensky Nature Immunology6, 331–337
(April 2005); doi:10.1038/ni1179
| Abstract | Full Text (HTML/PDF) |
review article Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma
C. M. Hawrylowicz and A. O'Garra Nature Reviews Immunology5, 271–283
(2005); doi:10.1038/nri1589
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letter A chimeric human-cat fusion protein blocks cat-induced allergy
Daocheng Zhu, Christopher L Kepley, Ke Zhang, Tetsuya Terada, Takechiyo Yamada and Andrew Saxon Nature Medicine11, 446–449
(April 2005); doi:10.1038/nm1219
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news and views Nipping cat allergy with fusion proteins
Janet Kalesnikoff and Stephen J Galli Nature Medicine11, 381–382
(April 2005); doi:10.1038/nm0405-381
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perspectives Timeline: Leukaemia stem cells and the evolution of cancer-stem-cell research
Brian J. P. Huntly and D. Gary Gilliland Nature Reviews Cancer5, 311–321
(April 2005); doi:10.1038/nrc1592
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brief communication A centrosomal mechanism involving CDK5RAP2 and CENPJ controls brain size
Jacquelyn Bond, Emma Roberts, Kelly Springell, Sophia Lizarraga, Sheila Scott, Julie Higgins, Daniel J Hampshire, Ewan E Morrison, Gabriella F Leal, Elias O Silva, Suzana M R Costa, Diana Baralle, Michela Raponi, Gulshan Karbani, Yasmin Rashid, Hussain Jafri, Christopher Bennett, Peter Corry, Christopher A Walsh and C Geoffrey Woods Nature Genetics37, 353–355
(April 2005); doi:10.1038/ng1539
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review article Nuclear receptors — a perspective from Drosophila
Kirst King-Jones and Carl S. Thummel Nature Reviews Genetics6, 311–323
(April 2005); doi:10.1038/nrg1581
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article G protein βγ directly regulates SNARE protein fusion machinery for secretory granule exocytosis
Trillium Blackmer, Eric C Larsen, Cheryl Bartleson, Judith A Kowalchyk, Eun-Ja Yoon, Anita M Preininger, Simon Alford, Heidi E Hamm and Thomas F J Martin Nature Neuroscience8, 421–425
(April 2005); doi:10.1038/nn1423
| Abstract | Full Text (HTML/PDF) |
article Crystal structure of archaeal toxin-antitoxin RelE-RelB complex with implications for toxin activity and antitoxin effects
Hisanori Takagi, Yoshimitsu Kakuta, Takahiro Okada, Min Yao, Isao Tanaka and Makoto Kimura Nature Structural and Molecular Biology12, 327–331
(April 2005); doi:10.1038/nsmb911
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news and views RelBE or not to be
Daniel N Wilson and Knud H Nierhaus Nature Structural and Molecular Biology12, 282–284
(April 2005); doi:10.1038/nsmb0405-282
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article Purified Argonaute2 and an siRNA form recombinant human RISC
Fabiola V Rivas, Niraj H Tolia, Ji-Joon Song, Juan P Aragon, Jidong Liu, Gregory J Hannon and Leemor Joshua-Tor Nature Structural and Molecular Biology12, 340–349
(April 2005); doi:10.1038/nsmb918
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article Photo-leucine and photo-methionine allow identification of protein-protein interactions in living cells
Monika Suchanek, Anna Radzikowska and Christoph Thiele Nature Methods2, 261–268
(April 2005); doi:10.1038/nmeth752
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article Identification of microRNAs of the herpesvirus family
Sébastien Pfeffer, Alain Sewer, Mariana Lagos-Quintana, Robert Sheridan, Chris Sander, Friedrich A Grässer, Linda F van Dyk, C Kiong Ho, Stewart Shuman, Minchen Chien, James J Russo, Jingyue Ju, Glenn Randall, Brett D Lindenbach, Charles M Rice, Viviana Simon, David D Ho, Mihaela Zavolan and Thomas Tuschl Nature Methods2, 269–276
(April 2005); doi:10.1038/nmeth746
| Abstract | Full Text (HTML/PDF) |
news and views Herpesviruses throw a curve ball: new insights into microRNA biogenesis and evolution
Joel R Neilson & Phillip A Sharp Nature Methods2, 252–254
(April 2005); doi:10.1038/nmeth0405-252
| Abstract | Full Text (HTML/PDF) |
review article Insights into host responses against pathogens from transcriptional profiling
Richard G. Jenner and Richard A. Young Nature Reviews Microbiology3, 281–294
(April 2005); doi:10.1038/nrmicro1126
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article CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair
Fumiko Esashi, Nicole Christ, Julian Gannon, Yilun Liu, Tim Hunt, Maria Jasin and Stephen C. West Nature434, 598–604
(31 March 2005); doi:10.1038/nature03404
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article Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
Jacob Falck, Julia Coates and Stephen P. Jackson Nature434, 605–611
(31 March 2005); doi:10.1038/nature03442
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letters to nature Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death
Takashi Nakagawa , Shigeomi Shimizu, Tetsuya Watanabe, Osamu Yamaguchi, Kinya Otsu, Hirotaka Yamagata, Hidenori Inohara, Takeshi Kubo and Yoshihide Tsujimoto Nature434, 652–658
(31 March 2005); doi:10.1038/nature03317
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letters to nature Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death
Christopher P. Baines, Robert A. Kaiser, Nicole H. Purcell, N. Scott Blair, Hanna Osinska, Michael A. Hambleton, Eric W. Brunskill, M. Richard Sayen, Roberta A. Gottlieb, Gerald W. Dorn II, Jeffrey Robbins and Jeffery D. Molkentin Nature434, 658–662
(31 March 2005); doi:10.1038/nature03434
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letters to nature Structural insights into mRNA recognition from a PIWI domain-siRNA guide complex
James S. Parker, S. Mark Roe and David Barford Nature434, 663–666
(31 March 2005); doi:10.1038/nature03462
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letters to nature Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein
Jin-Biao Ma, Yu-Ren Yuan, Gunter Meister, Yi Pei, Thomas Tuschl and Dinshaw J. Patel Nature434, 666–670
(31 March 2005); doi:10.1038/nature03514
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letter Phosphoregulation of Arp2/3-dependent actin assembly during receptor-mediated endocytosis
Jiro Toshima, Junko Y. Toshima, Adam C. Martin and David G. Drubin Nature Cell Biology7, 246–254
(March 2005); doi:10.1038/ncb1229
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news and views An endocytic Prk-ing brake
Mara C. Duncan and Gregory S. Payne Nature Cell Biology7, 210–212
(March 2005); doi:10.1038/ncb0305-210
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review article Thinking quantitatively about transcriptional regulation
Sandra J. Greive and Peter H. von Hippel Nature Reviews Molecular Cell Biology6, 221–232
(March 2005); doi:10.1038/nrm1588
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article Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance
Andrew W Duncan, Frédérique M Rattis, Leah N DiMascio, Kendra L Congdon, Gregory Pazianos, Chen Zhao, Keejung Yoon, J Michael Cook, Karl Willert, Nicholas Gaiano and Tannishtha Reya Nature Immunology6, 314–322
(March 2005); doi:10.1038/ni1164
| Abstract | Full Text (HTML/PDF) |
news and views Defining 'stemness': Notch and Wnt join forces?
Sten Eirik W Jacobsen Nature Immunology6, 234–236
(March 2005); doi:10.1038/ni0305-234
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article Vav3 regulates osteoclast function and bone mass
Roberta Faccio, Steven L Teitelbaum, Keiko Fujikawa, Jean Chappel, Alberta Zallone, Victor L Tybulewicz, F Patrick Ross and Wojciech Swat Nature Medicine11, 284–290
(March 2005); doi:10.1038/nm1194
| Abstract | Full Text (HTML/PDF) |
letter Regulation of NKT cell development by SAP, the protein defective in XLP
Kim E Nichols, Jamie Hom, Shun-You Gong, Arupa Ganguly, Cindy S Ma, Jennifer L Cannons, Stuart G Tangye, Pamela L Schwartzberg, Gary A Koretzky and Paul L Stein Nature Medicine11, 340–345
(March 2005); doi:10.1038/nm1189
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news and views The need for natural killer T cells
H Robson MacDonald and Jens Schümann Nature Medicine11, 256–257
(March 2005); doi:10.1038/nm0305-256
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review article The promise of genetically engineered mice for cancer prevention studies
Jeffrey E. Green and Tamaro Hudson Nature Reviews Cancer5, 184–198
(March 2005); doi:10.1038/nrc1565
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brief communication Mutations of the catalytic subunit of RAB3GAP cause Warburg Micro syndrome
Irene A Aligianis, Colin A Johnson, Paul Gissen, Dongrong Chen, Daniel Hampshire, Katrin Hoffmann, Esther N Maina, Neil V Morgan, Louise Tee, Jenny Morton, John R Ainsworth, Denise Horn, Elisabeth Rosser, Trevor R P Cole, Irene Stolte-Dijkstra, Karen Fieggen, Jill Clayton-Smith, André Mégarbané, Julian P Shield, Ruth Newbury-Ecob, William B Dobyns, John M Graham, Jr Klaus W Kjaer, Mette Warburg, Jacqueline Bond, Richard C Trembath, Laura W Harris, Yoshimi Takai, Stefan Mundlos, David Tannahill, C Geoffery Woods and Eamonn R Maher Nature Genetics37, 221–224
(March 2005); doi:10.1038/ng1517
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review article Induction and suppression of RNA silencing: insights from viral infections
Olivier Voinnet Nature Reviews Genetics6, 206–220
(March 2005); doi:10.1038/nrg1555
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article Sonic hedgehog guides commissural axons along the longitudinal axis of the spinal cord
Dimitris Bourikas, Vladimir Pekarik, Thomas Baeriswyl, Åsa Grunditz, Rejina Sadhu, Michele Nardó and Esther T Stoeckli Nature Neuroscience8, 297–304
(March 2005); doi:10.1038/nn1396
| Abstract | Full Text (HTML/PDF) |
research article A small molecule-kinase interaction map for clinical kinase inhibitors
Miles A Fabian, William H Biggs, III Daniel K Treiber, Corey E Atteridge, Mihai D Azimioara, Michael G Benedetti, Todd A Carter, Pietro Ciceri, Philip T Edeen, Mark Floyd, Julia M Ford, Margaret Galvin, Jay L Gerlach, Robert M Grotzfeld, Sanna Herrgard, Darren E Insko, Michael A Insko, Andiliy G Lai, Jean-Michel Lélias, Shamal A Mehta, Zdravko V Milanov, Anne Marie Velasco, Lisa M Wodicka, Hitesh K Patel, Patrick P Zarrinkar and David J Lockhart Nature Biotechnology23, 329–336
(March 2005); doi:10.1038/nbt1068
| Abstract | Full Text (HTML/PDF) |
news and views Interaction maps for kinase inhibitors
James D Griffin Nature Biotechnology23, 308–309
(March 2005); doi:10.1038/nbt0305-308
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news and views RecA kicks Pol V into gear
Joann B Sweasy Nature Structural and Molecular Biology12, 215–216
(March 2005); doi:10.1038/nsmb0305-215
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research article Pulse proteolysis: A simple method for quantitative determination of protein stability and ligand binding
Chiwook Park and Susan Marqusee Nature Methods2, 207–212
(March 2005); doi:10.1038/nmeth740
| Abstract | Full Text (HTML/PDF) |
ej
í, Karen Koed, Alwin Krämer, Frederic Tort, Karsten Zieger, Per Guldberg, Maxwell Sehested, Jahn M. Nesland, Claudia Lukas, Torben Ørntoft, Jiri Lukas and Jiri Bartek