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Research library: browse by date

May 2005

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The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.

Click here for free access to the 'Featured Articles' section, with new articles every week.

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article
The F-box protein TIR1 is an auxin receptor
Nihal Dharmasiri, Sunethra Dharmasiri and Mark Estelle
Nature 435, 441–445
(26 May 2005); doi:10.1038/nature03543
| Summary | Full Text (HTML / PDF) |

article
The Arabidopsis F-box protein TIR1 is an auxin receptor
Stefan Kepinski and Ottoline Leyser
Nature 435, 446–451
(26 May 2005); doi:10.1038/nature03542
| Summary | Full Text (HTML / PDF) |

news and views
Plant biology: Auxin action
Judy Callis
Nature 435, 436–437
(26 May 2005); doi:10.1038/435436b
| Full Text (HTML / PDF) |

article
A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity
Carola G. Vinuesa, Matthew C. Cook, Constanza Angelucci, Vicki Athanasopoulos, Lixin Rui, Kim M. Hill, Di Yu, Heather Domaschenz, Belinda Whittle, Teresa Lambe, Ian S. Roberts, Richard R. Copley, John I. Bell, Richard J. Cornall and Christopher C. Goodnow
Nature 435, 452–458
(26 May 2005); doi:10.1038/nature03555
| Summary | Full Text (HTML / PDF) |

letter to nature
Allosteric modulation of the presynaptic Ca2+ sensor for vesicle fusion
Xuelin Lou, Volker Scheuss and Ralf Schneggenburger
Nature 435, 497–501
(26 May 2005); doi:10.1038/nature03568
| First Paragraph | Full Text (HTML / PDF) |

letter to nature
Polo kinase links the stress pathway to cell cycle control and tip growth in fission yeast
Janni Petersen and Iain M. Hagan
Nature 435, 507–512
(26 May 2005); doi:10.1038/nature03590
| First Paragraph | Full Text (HTML / PDF) |

letter to nature
Structural and mechanistic insights into the interaction between Rho and mammalian Dia
R. Rose, M. Weyand, M. Lammers, T. Ishizaki, M. R. Ahmadian and A. Wittinghofer
Nature 435, 513–518
(26 May 2005); doi:10.1038/nature03604
| First Paragraph | Full Text (HTML / PDF) |

letter to nature
Insights into microtubule nucleation from the crystal structure of human γ-tubulin
Hector Aldaz , Luke M. Rice, Tim Stearns and David A. Agard
Nature 435, 523–527
(26 May 2005); doi:10.1038/nature03586
| First Paragraph | Full Text (HTML / PDF) |

article
The KIF3 motor transports N-cadherin and organizes the developing neuroepithelium
Junlin Teng, Tatemitsu Rai, Yosuke Tanaka, Yosuke Takei, Takao Nakata, Motoyuki Hirasawa, Ashok B. Kulkarni and Nobutaka Hirokawa
Nature Cell Biology 7, 474–482
(May 2005); doi:10.1038/ncb1249
| Abstract | Full Text (HTML/PDF) |

news and views
When domestiques rebel: kinesins, cadherins and neuronal proliferation
Cara J. Gottardi, Nicole R. den Elzen and Alpha S. Yap
Nature Cell Biology 7, 445–447
(May 2005); doi:10.1038/ncb0505-445
| Full Text (HTML/PDF) |

article
T cell costimulation by chemokine receptors
Barbara Molon, Giorgia Gri, Monica Bettella, Concepción Gómez-Moutón, Antonio Lanzavecchia, Carlos Martínez-A, Santos Mañes and Antonella Viola
Nature Immunology 6, 465–471
(May 2005); doi:10.1038/ni1191
| Abstract | Full Text (HTML/PDF) |

article
Lineage infidelity of epithelial ovarian cancers is controlled by HOX genes that specify regional identity in the reproductive tract
Wenjun Cheng, Jinsong Liu, Hiroyuki Yoshida, Daniel Rosen and Honami Naora
Nature Medicine 11, 531–537
(May 2005); doi:10.1038/nm1230
| Abstract | Full Text (HTML/PDF) |

letter
Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action
Emilie A Bard-Chapeau, Andrea L Hevener, Shinong Long, Eric E Zhang, Jerrold M Olefsky and Gen-Sheng Feng
Nature Medicine 11, 567–571
(May 2005); doi:10.1038/nm1227
| First Paragraph | Full Text (HTML/PDF) |

review article
The RUNX genes: gain or loss of function in cancer
Karen Blyth, Ewan R. Cameron and James C. Neil
Nature Reviews Cancer 5, 376–387
(2005) doi:10.1038/nrc1607
| Summary | Full Text (HTML / PDF) |

letter
Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways
Matias Simons, Joachim Gloy, Athina Ganner, Axel Bullerkotte, Mikhail Bashkurov, Corinna Krönig, Bernhard Schermer, Thomas Benzing, Olga A Cabello, Andreas Jenny, Marek Mlodzik, Bozena Polok, Wolfgang Driever, Tomoko Obara and Gerd Walz
Nature Genetics 37, 537–543
(May 2005); doi:10.1038/ng1552
| First Paragraph | Full Text (HTML/PDF) |

news and views
Linking cilia to Wnts
Gregory G Germino
Nature Genetics 37, 455–457
(May 2005); doi:10.1038/ng0505-455
| Full Text (HTML/PDF) |

article
Asymmetric membrane ganglioside sialidase activity specifies axonal fate
Jorge Santos Da Silva, Takafumi Hasegawa, Taeko Miyagi, Carlos G Dotti and Jose Abad-Rodriguez
Nature Neuroscience 8, 606–615
(May 2005); doi:10.1038/nn1442
| Abstract | Full Text (HTML/PDF) |

news and views
Axon formation: fate versus growth
Hui Jiang and Yi Rao
Nature Neuroscience 8, 544–546
(May 2005); doi:10.1038/nn0505-544
| Full Text (HTML/PDF) |

research article
Quantitative mouse brain proteomics using culture-derived isotope tags as internal standards
Yasushi Ishihama, Toshitaka Sato, Tsuyoshi Tabata, Norimasa Miyamoto, Koji Sagane, Takeshi Nagasu and Yoshiya Oda
Nature Biotechnology 23, 617–621
(May 2005); doi:10.1038/nbt1086
| First Paragraph | Full Text (HTML/PDF) |

research article
Enzyme family-specific and activity-based screening of chemical libraries using enzyme microarrays
Daniel P Funeriu, Jörg Eppinger, Lucile Denizot, Masato Miyake and Jun Miyake
Nature Biotechnology 23, 622–627
(May 2005); doi:10.1038/nbt1090
| First Paragraph | Full Text (HTML/PDF) |

review article
Regulators of apoptosis: suitable targets for immune therapy of cancer
Mads Hald Andersen , Jürgen C. Becker and Per thor Straten
Nature Reviews Drug Discovery 4, 399–409
(May 2005); doi:10.1038/nrd1717
| Summary | Full Text (HTML / PDF) |

article
The Hop2 and Mnd1 proteins act in concert with Rad51 and Dmc1 in meiotic recombination
Galina V Petukhova, Roberto J Pezza, Filip Vanevski, Mickael Ploquin, Jean-Yves Masson and R Daniel Camerini-Otero
Nature Structural and Molecular Biology 12, 449–453
(May 2005); doi:10.1038/nsmb923
| Abstract | Full Text (HTML/PDF) |

news and views
An Achilles' heel for breast cancer?
Keith W Caldecott and Anthony Chalmers
Nature Structural and Molecular Biology 12, 387–388
(May 2005); doi:10.1038/nsmb0505-387
| Full Text (HTML/PDF) |

article
Quantitative analysis of gene expression in living adult neural stem cells by gene trapping
John R Scheel, Jasodhara Ray, Fred H Gage and Carrolee Barlow
Nature Methods 2, 363–370
(May 2005); doi:10.1038/nmeth755
| Abstract | Full Text (HTML/PDF) |

article
Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction
Kei Sakamoto, Afshan McCarthy, Darrin Smith, Kevin A Green, D Grahame Hardie, Alan Ashworth and Dario R Alessi
The EMBO Journal 24, 1810–1820
(May 2005); doi:10.1038/sj.emboj.7600667
| Abstract | Full Text (HTML/PDF) |

review article
Bacterial cytotoxins: targeting eukaryotic switches
Klaus Aktories and Joseph T. Barbieri
Nature Reviews Microbiology 12, 397–410
(May 2005); doi:10.1038/nrmicro1150
| Abstract | Full Text (HTML/PDF) |

letter
Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II
Min Hee Choi, In Kyung Lee, Gyung Whan Kim, Bang Ul Kim, Ying-Hao Han, Dae-Yeul Yu, Hye Sun Park, Kyung Yong Kim, Jong Seo Lee, Chulhee Choi, Yun Soo Bae, Byung In Lee, Sue Goo Rhee and Sang Won Kang
Nature 435, 347–353
(19 May 2005); doi:10.1038/nature03587
| First Paragraph | Full Text (HTML / PDF) |

letter
The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity
Mitsuru Morimoto, Yu Takahashi, Maho Endo and Yumiko Saga
Nature 435, 354–359
(19 May 2005); doi:10.1038/nature03591
| First Paragraph | Full Text (HTML / PDF) |

letter
Integrin-independent repression of cadherin transcription by talin during axis formation in Drosophila
Isabelle E. Bécam, Guy Tanentzapf, Jean-Antoine Lepesant, Nicholas H. Brown and Jean-René Huynh
Nature Cell Biology 7, 510–516
(May 2005); doi:10.1038/ncb1253
| First Paragraph | Full Text (HTML/PDF) |

news and views
Talin's second persona
Ulrich Tepass and Dorothea Godt
Nature Cell Biology 7, 443–444
(May 2005); doi:10.1038/ncb0505-443
| Full Text (HTML/PDF) |

news and views
Dpp gets in shape
Alison Schuldt
Nature Cell Biology 7, 456
(May 2005); doi:10.1038/ncb0505-456
| Full Text (HTML/PDF) |

perspectives
Phosphorylation-specific prolyl isomerization: is there an underlying theme?
Gerburg Wulf, Greg Finn, Futoshi Suizu and Kun Ping Lu
Nature Cell Biology 7, 435–441
(May 2005); doi:10.1038/ncb0505-435
| Abstract | Full Text (HTML/PDF) |

article
Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines
Revital Shamri, Valentin Grabovsky, Jean–Marc Gauguet, Sara Feigelson, Eugenia Manevich, Waldemar Kolanus, Martyn K Robinson, Donald E Staunton, Ulrich H von Andrian and Ronen Alon
Nature Immunology 6, 497–506
(May 2005); doi:10.1038/ni1194
| Abstract | Full Text (HTML/PDF) |

news and views
Integrin activation under flow: a local affair
Carlo Laudanna
Nature Immunology 6, 429–430
(May 2005); doi:10.1038/ni0505-429
| Full Text (HTML/PDF) |

article
Inhibition of the NKp30 activating receptor by pp65 of human cytomegalovirus
Tal I Arnon, Hagit Achdout, Ofer Levi, Gal Markel, Nivin Saleh, Gil Katz, Roi Gazit, Tsufit Gonen-Gross, Jacob Hanna, Efrat Nahari, Angel Porgador, Alik Honigman, Bodo Plachter, Dror Mevorach, Dana G Wolf and Ofer Mandelboim
Nature Immunology 6, 515–523
(May 2005); doi:10.1038/ni1190
| Abstract | Full Text (HTML/PDF) |

article
Lactadherin promotes VEGF-dependent neovascularization
Jean-Sébastien Silvestre, Clotilde Théry, Ghislaine Hamard, Jacques Boddaert, Barbara Aguilar, Alain Delcayre, Christophe Houbron, Radia Tamarat, Olivier Blanc-Brude, Sylvia Heeneman, Michel Clergue, Micheline Duriez, Régine Merval, Bernard Lévy, Alain Tedgui, Sebastian Amigorena and Ziad Mallat
Nature Medicine 11, 499–506
(May 2005); doi:10.1038/nm1233
| Abstract | Full Text (HTML/PDF) |

review article
ERBB receptors and cancer: the complexity of targeted inhibitors
Nancy E. Hynes and Heidi A. Lane
Nature Reviews Cancer 5, 341–354
(May 2005); doi:10.1038/nrc1609
| Summary | Full Text (HTML / PDF) |

letter
Combinatorial microRNA target predictions
Azra Krek, Dominic Grün, Matthew N Poy, Rachel Wolf, Lauren Rosenberg, Eric J Epstein, Philip MacMenamin, Isabelle da Piedade, Kristin C Gunsalus, Markus Stoffel and Nikolaus Rajewsky
Nature Genetics 37, 495–500
(May 2005); doi:10.1038/ng1536
| First Paragraph | Full Text (HTML/PDF) |

article
α-Synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease
Li Chen and Mel B Feany
Nature Neuroscience 8, 657–663
(May 2005); doi:10.1038/nn1443
| Abstract | Full Text (HTML/PDF) |

research article
Gene knockdown by large circular antisense for high-throughput functional genomics
Yun-Han Lee, Ik-Jae Moon, Bin Hur, Jeong-Hoh Park, Kil-Hwan Han, Seok-Yong Uhm, Yong-Joo Kim, Koo-Jeong Kang, Jong-Wook Park, Young-Bae Seu, Young-Ho Kim and Jong-Gu Park
Nature Biotechnology 23, 591–599
(May 2005); doi:10.1038/nbt1089
| Abstract | Full Text (HTML/PDF) |

research article
Migration and differentiation of neural precursors derived from human embryonic stem cells in the rat brain
Viviane Tabar, Georgia Panagiotakos, Edward D Greenberg, Bill K Chan, Michel Sadelain, Philip H Gutin and Lorenz Studer
Nature Biotechnology 23, 601–606
(May 2005); doi:10.1038/nbt1088
| First Paragraph | Full Text (HTML/PDF) |

research article
Transient inhibition of BMP signaling by Noggin induces cardiomyocyte differentiation of mouse embryonic stem cells
Shinsuke Yuasa, Yuji Itabashi, Uichi Koshimizu, Tomofumi Tanaka, Keijiro Sugimura, Masayoshi Kinoshita, Fumiyuki Hattori, Shin-ichi Fukami, Takuya Shimazaki, Hideyuki Okano, Satoshi Ogawa and Keiichi Fukuda
Nature Biotechnology 23, 607–611
(May 2005); doi:10.1038/nbt1093
| First Paragraph | Full Text (HTML/PDF) |

review article
Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors
Prakash Jagtap and Csaba Szabó
Nature Reviews Drug Discovery 4, 421–440
(May 2005); doi:10.1038/nrd1718
| Summary | Full Text (HTML / PDF) |

article
Hemifusion in SNARE-mediated membrane fusion
Yibin Xu, Fan Zhang, Zengliu Su, James A McNew and Yeon-Kyun Shin
Nature Structural and Molecular Biology 12, 417–422
(May 2005); doi:10.1038/nsmb921
| Abstract | Full Text (HTML/PDF) |

news and views
Searching for the silver lining
Judith M White and J David Castle
Nature Structural and Molecular Biology 12, 382–384
(May 2005); doi:10.1038/nsmb0505-382
| Full Text (HTML/PDF) |

article
Monitoring macromolecular complexes involved in the chaperonin-assisted protein folding cycle by mass spectrometry
Esther van Duijn, Patrick J Bakkes, Ron M A Heeren, Robert H H van den Heuvel, Harm van Heerikhuizen, Saskia M van der Vies and Albert J R Heck
Nature Methods 2, 371–376
(May 2005); doi:10.1038/nmeth753
| Abstract | Full Text (HTML/PDF) |

news and views
Watching and weighting—chaperone complexes in action
Carol V Robinson
Nature Methods 2, 331–332
(May 2005); doi:10.1038/nmeth0505-331
| Abstract | Full Text (HTML/PDF) |

review article
Making 'sense' of metabolism: autoinducer–2, luxs and pathogenic bacteria
Agnès Vendeville, Klaus Winzer, Karin Heurlier, Christoph M. Tang and Kim R. Hardie
Nature Reviews Microbiology 3, 383–396
(May 2005); doi:10.1038/nrmicro1146
| Summary | Full Text (HTML / PDF) |

article
Retinoic acid signalling links left-right asymmetric patterning and bilaterally symmetric somitogenesis in the zebrafish embryo
Yasuhiko Kawakami, Ángel Raya, R. Marina Raya, Concepción Rodríguez-Esteban and Juan Carlos Izpisúa Belmonte
Nature 435, 165–171
(12 May 2005); doi:10.1038/nature03512
| Summary | Full Text (HTML / PDF) |

news and views
Developmental biology: Asymmetrical threat averted
Eran Hornstein and Clifford J. Tabin
Nature 435, 155–156
(12 May 2005); doi:10.1038/435155a
| Full Text (HTML / PDF) |

article
FGF-induced vesicular release of Sonic hedgehog and retinoic acid in leftward nodal flow is critical for left-right determination
Yosuke Tanaka, Yasushi Okada and Nobutaka Hirokawa
Nature 435, 172–177
(12 May 2005); doi:10.1038/nature03494
| Summary | Full Text (HTML / PDF) |

letters to nature
Retinoic acid coordinates somitogenesis and left-right patterning in vertebrate embryos
Julien Vermot and Olivier Pourquié
′Nature 435, 215–220
(12 May 2005); doi:10.1038/nature03488
| First Paragraph | Full Text (HTML / PDF) |

article
Actin and Arf1-dependent recruitment of a cortactin-dynamin complex to the Golgi regulates post-Golgi transport
Hong Cao, Shaun Weller, James D. Orth, Jing Chen, Bing Huang, Ji-Long Chen, Mark Stamnes and Mark A. McNiven
Nature Cell Biology 7, 483–492
(May 2005); doi:10.1038/ncb1246
| Abstract | Full Text (HTML/PDF) |

news and views
Extending the court for cortactin: from the cortex to the Golgi
Michael M. Kessels and Britta Qualmann
Nature Cell Biology 7, 448–449
(May 2005); doi:10.1038/ncb0505-448
| Full Text (HTML/PDF) |

letter
EphrinB-EphB signalling regulates clathrin-mediated endocytosis through tyrosine phosphorylation of synaptojanin 1
Fumitoshi Irie, Misako Okuno, Elena B. Pasquale and Yu Yamaguchi
Nature Cell Biology 7, 501–509
(May 2005); doi:10.1038/ncb1252
| First Paragraph | Full Text (HTML/PDF) |

news and views
Ephrin tempers two-faced synaptojanin 1
Neil A. Hopper and Vincent O'Connor
Nature Cell Biology 7, 454–456
(May 2005); doi:10.1038/ncb0505-454
| Full Text (HTML/PDF) |

article
Egr-2 and Egr-3 are negative regulators of T cell activation
Meredith Safford, Samuel Collins, Michael A Lutz, Amy Allen, Ching-Tai Huang, Jeanne Kowalski, Amanda Blackford, Maureen R Horton, Charles Drake, Ronald H Schwartz and Jonathan D Powell
Nature Immunology 6, 472–480
(May 2005); doi:10.1038/ni1193
| Abstract | Full Text (HTML/PDF) |

review article
Mechanisms of type-I- and type-II-interferon-mediated signalling
Leonidas C. Platanias
Nature Reviews Immunology 5, 375–386
(May 2005); doi:10.1038/nri1604
| Summary | Full Text (HTML / PDF) |

article
Integrin αvβ3 is a coreceptor for human cytomegalovirus
Xin Wang, David Y Huang, Shu-Mei Huong and Eng-Shang Huang
Nature Medicine 11, 515–521
(June 2005); doi:10.1038/nm1236
| Abstract | Full Text (HTML/PDF) |

news and views
Do-all receptor takes on coagulation, inflammation
Charles Esmon
Nature Medicine 11, 475–477
(May 2005); doi:10.1038/nm0505-475
| Full Text (HTML/PDF) |

article
Epistasis analysis with global transcriptional phenotypes
Nancy Van Driessche, Janez Demsar, Ezgi O Booth, Paul Hill, Peter Juvan, Blaz Zupan, Adam Kuspa and Gad Shaulsky
Nature Genetics 37, 471–477
(May 2005); doi:10.1038/ng1545
| Abstract | Full Text (HTML/PDF) |

news and views
Universal epistasis analysis
Timothy R Hughes
Nature Genetics 37, 457–458
(May 2005); doi:10.1038/ng0505-457
| Full Text (HTML/PDF) |

article
Gβγ acts at the C terminus of SNAP-25 to mediate presynaptic inhibition
Tatyana Gerachshenko, Trillium Blackmer, Eun-Ja Yoon, Cheryl Bartleson, Heidi E Hamm and Simon Alford
Nature Neuroscience 8, 597–605
(May 2005); doi:10.1038/nn1439
| Abstract | Full Text (HTML/PDF) |

news and views
Finding the G spot on fusion machinery
Jane Sullivan
Nature Neuroscience 8, 542–544
(May 2005); doi:10.1038/nn0505-542
| Full Text (HTML/PDF) |

review article
WNTS in the vertebrate nervous system: from patterning to neuronal connectivity
Lorenza Ciani and Patricia C. Salinas
Nature Reviews Neuroscience 6, 351–362
(May 2005); doi:10.1038/nrn1665
| Summary | Full Text (HTML / PDF) |

analysis
Systematic interpretation of genetic interactions using protein networks
Ryan Kelley and Trey Ideker
Nature Biotechnology 23, 561–566
(May 2005); doi:10.1038/nbt1096
| Abstract | Full Text (HTML/PDF) |

research article
Baculovirus as versatile vectors for protein expression in insect and mammalian cells
Thomas A Kost, J Patrick Condreay and Donald L Jarvis
Nature Biotechnology 23, 567–575
(May 2005); doi:10.1038/nbt1095
| Abstract | Full Text (HTML/PDF) |

perspective
Neural stem cells and neurospheres — re-evaluating the relationship
Brent A Reynolds and Rodney L Rietze
Nature Methods 2, 333–336
(May 2005); doi:10.1038/nmeth758
| Abstract | Full Text (HTML/PDF) |

article
The genome of the social amoeba Dictyostelium discoideum
L.Eichinger, J. A. Pachebat, G. Glöckner, M.-A. Rajandream, R. Sucgang , M. Berriman , J. Song , R. Olsen , K. Szafranski , Q. Xu , B. Tunggal , S. Kummerfeld , M. Madera , B. A. Konfortov , F. Rivero , A. T. Bankier , R. Lehmann , N. Hamlin , R. Davies , P. Gaudet , P. Fey , K. Pilcher , G. Chen , D. Saunders , E. Sodergren , P. Davis , A. Kerhornou , X. Nie , N. Hall , C. Anjard , L. Hemphill , N. Bason , P. Farbrother , B. Desany , E. Just , T. Morio , R. Rost , C. Churcher , J. Cooper , S. Haydock , N. van Driessche , A. Cronin , I. Goodhead , D. Muzny , T. Mourier , A. Pain , M. Lu , D. Harper , R. Lindsay , H. Hauser , K. James , M. Quiles , M. Madan Babu , T. Saito , C. Buchrieser , A. Wardroper , M. Felder , M. Thangavelu , D. Johnson , A. Knights , H. Loulseged , K. Mungall , K. Oliver , C. Price , M. A. Quail , H. Urushihara , J. Hernandez , E. Rabbinowitsch , D. Steffen , M. Sanders , J. Ma , Y. Kohara , S. Sharp , M. Simmonds , S. Spiegler , A. Tivey , S. Sugano , B. White , D. Walker , J. Woodward , T. Winckler , Y. Tanaka , G. Shaulsky , M. Schleicher , G. Weinstock , A. Rosenthal , E. C. Cox , R. L. Chisholm , R. Gibbs , W. F. Loomis , M. Platzer , R. R. Kay , J. Williams , P. H. Dear , A. A. Noegel , B. Barrell and A. Kuspa
Nature 435, 43–57
(05 May 2005); doi:10.1038/nature03481
| Summary | Full Text (HTML / PDF) |

article
Lipoprotein particles are required for Hedgehog and Wingless signalling
Daniela Panáková, Hein Sprong, Eric Marois, Christoph Thiele and Suzanne Eaton
Nature 435, 58–65
(05 May 2005); doi:10.1038/nature03504
| Summary | Full Text (HTML / PDF) |

news and views
Developmental biology: Morphogens hitch a greasy ride
Richard S. Mann and Joaquim Culi
Nature 435, 30–33
(05 May 2005); doi:10.1038/435030a
| Full Text (HTML / PDF) |

letters to nature
Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity
Li-Ru You, Fu-Jung Lin, Christopher T. Lee, Francesco J. DeMayo, Ming-Jer Tsai and Sophia Y. Tsai
Nature 435, 98–104
(05 May 2005); doi:10.1038/nature03511
| First Paragraph | Full Text (HTML / PDF) |

letters to nature
The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks
Lukas C. Kapitein, Erwin J. G. Peterman, Benjamin H. Kwok, Jeffrey H. Kim, Tarun M. Kapoor and Christoph F. Schmidt
Nature 435, 114–118
(05 May 2005); doi:10.1038/nature03503
| First Paragraph | Full Text (HTML / PDF) |

article
APC is a component of an organizing template for cortical microtubule networks
Amy Reilein and W. James Nelson
Nature Cell Biology 7, 463–473
(May 2005); doi:10.1038/ncb1248
| Abstract | Full Text (HTML/PDF) |

article
Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase
Alan Lau, Karra M. Swinbank, Parvin S. Ahmed, Debra L. Taylor, Stephen P. Jackson, Graeme C. M. Smith and Mark J. O'Connor
Nature Cell Biology 7, 493–500
(May 2005); doi:10.1038/ncb1250
| Abstract | Full Text (HTML/PDF) |

news and views
ATM: HIV-1's Achilles heel?
René Daniel and Roger J. Pomerantz
Nature Cell Biology 7, 452–453
(May 2005); doi:10.1038/ncb0505-452
| Full Text (HTML/PDF) |

news and views
Tea for three: control of fission yeast polarity
Hilary A. Snaith and Kenneth E. Sawin
Nature Cell Biology 7, 450–451
(May 2005); doi:10.1038/ncb0505-450
| Full Text (HTML/PDF) |

news and views
IRF-7 triggers the interferon alarm
Myrto Raftopoulou
Nature Cell Biology 7, 459
(May 2005); doi:10.1038/ncb0505-459
| Full Text (HTML/PDF) |

article
TIM-1 induces T cell activation and inhibits the development of peripheral tolerance
Sarah E Umetsu, Wan-Ling Lee, Jennifer J McIntire, Laura Downey, Bharati Sanjanwala, Omid Akbari, Gerald J Berry, Haruo Nagumo, Gordon J Freeman, Dale T Umetsu and Rosemarie H DeKruyff
Nature Immunology 6, 447–454
(May 2005); doi:10.1038/ni1186
| Abstract | Full Text (HTML/PDF) |

article
TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation
Jennifer Hartt Meyers, Sumone Chakravarti, David Schlesinger, Zsolt Illes, Hanspeter Waldner, Sarah E Umetsu, James Kenny, Xin Xiao Zheng, Dale T Umetsu, Rosemarie H DeKruyff, Terry B Strom and Vijay K Kuchroo
Nature Immunology 6, 455–464
(May 2005); doi:10.1038/ni1185
| Abstract | Full Text (HTML/PDF) |

review article
Interactions of NF-κB with chromatin: the art of being at the right place at the right time
Gioacchino Natoli, Simona Saccani, Daniela Bosisio and Ivan Marazzi
Nature Immunology 6, 439–445
(May 2005); doi:10.1038/ni1196
| Abstract | Full Text (HTML/PDF) |

review article
A new self: MHC-class-I-independent Natural-killer-cell self-tolerance
Vinay Kumar and Megan E. McNerney
Nature Reviews Immunology 5, 363–374
(May 2005); doi:10.1038/nri1603
| Summary | Full Text (HTML / PDF) |

article
Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice
Irina Petrache, Viswanathan Natarajan, Lijie Zhen, Terry R Medler, Amy T Richter, Chung Cho, Walter C Hubbard, Evgeny V Berdyshev and Rubin M Tuder
Nature Medicine 11, 491–498
(June 2005); doi:10.1038/nm1238
| Abstract | Full Text (HTML/PDF) |

news and views
Lipid let loose in pulmonary emphysema
Jack A Elias and Chun Geun Lee
Nature Medicine 11, 471–472
(May 2005); doi:10.1038/nm0505-471
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article
PI 3-kinase p110β: a new target for antithrombotic therapy
Shaun P Jackson, Simone M Schoenwaelder, Isaac Goncalves, Warwick S Nesbitt, Cindy L Yap, Christine E Wright, Vijaya Kenche, Karen E Anderson, Sacha M Dopheide, Yuping Yuan, Sharelle A Sturgeon, Hishani Prabaharan, Philip E Thompson, Gregg D Smith, Peter R Shepherd, Nathalie Daniele, Suhasini Kulkarni, Belinda Abbott, Dilek Saylik, Catherine Jones, Lucy Lu, Simon Giuliano, Sascha C Hughan, James A Angus, Alan D Robertson and Hatem H Salem
Nature Medicine 11, 507–514
(May 2005); doi:10.1038/nm1232
| Abstract | Full Text (HTML/PDF) |

article
A positive autoregulatory loop of Jak-STAT signaling controls the onset of astrogliogenesis
Fei He, Weihong Ge, Keri Martinowich, Sara Becker-Catania, Volkan Coskun, Wenyu Zhu, Hao Wu, Diogo Castro, Francois Guillemot, Guoping Fan, Jean de Vellis and Yi E Sun
Nature Neuroscience 8, 616–625
(May 2005); doi:10.1038/nn1440
| Abstract | Full Text (HTML/PDF) |

article
The MAPK pathway and Egr-1 mediate stress-related behavioral effects of glucocorticoids
Jean-Michel Revest, Francesco Di Blasi, Pierre Kitchener, Françoise Rougé-Pont, Aline Desmedt, Marc Turiault, François Tronche and Pier Vincenzo Piazza
Nature Neuroscience 8, 664–672
(May 2005); doi:10.1038/nn1441
| Abstract | Full Text (HTML/PDF) |

review article
From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndrome
Claudia Bagni and William T. Greenough
Nature Reviews Neuroscience 6, 376–387
(May 2005); doi:10.1038/nrn1667
| Summary | Full Text (HTML / PDF) |

review article
Rho kinase, a promising drug target for neurological disorders
Bernhard K. Mueller, Helmut Mack and Nicole Teusch
Nature Reviews Drug Discovery 4, 387–398
(May 2005); doi:10.1038/nrd1719
| Summary | Full Text (HTML / PDF) |

article
The Rad50 hook domain is a critical determinant of Mre11 complex functions
Jed J W Wiltzius, Marcel Hohl, James C Fleming and John H J Petrini
Nature Structural and Molecular Biology 12, 403–407
(May 2005); doi:10.1038/nsmb928
| Abstract | Full Text (HTML/PDF) |

news and views
Rad50 connects by hook or by crook
Michael Lichten
Nature Structural and Molecular Biology 12, 392–393
(May 2005); doi:10.1038/nsmb0505-392
| Full Text (HTML/PDF) |

news and views
Spindly clathrin
Evelyn Jabri
Nature Structural and Molecular Biology 12, 384
(May 2005); doi:10.1038/nsmb0505-384
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article
Independence and reproducibility across microarray platforms
Jennie E Larkin, Bryan C Frank, Haralambos Gavras, Razvan Sultana and John Quackenbush
Nature Methods 2, 337–344
(May 2005); doi:10.1038/nmeth757
| Abstract | Full Text (HTML/PDF) |

article
Multiple-laboratory comparison of microarray platforms
Rafael A Irizarry, Daniel Warren, Forrest Spencer, Irene F Kim, Shyam Biswal, Bryan C Frank, Edward Gabrielson, Joe G N Garcia, Joel Geoghegan, Gregory Germino, Constance Griffin, Sara C Hilmer, Eric Hoffman, Anne E Jedlicka, Ernest Kawasaki, Francisco Martínez-Murillo, Laura Morsberger, Hannah Lee, David Petersen, John Quackenbush, Alan Scott, Michael Wilson, Yanqin Yang, Shui Qing Ye and Wayne Yu
Nature Methods 2, 345–350
(May 2005); doi:10.1038/nmeth756
| Abstract | Full Text (HTML/PDF) |

article
Standardizing global gene expression analysis between laboratories and across platforms
Members of the Toxicogenomics Research Consortium: B.K. Weis
Nature Methods 2, 351–356
(May 2005); doi:10.1038/nmeth754
| Abstract | Full Text (HTML/PDF) |

news and views
Of fish and chips
Gavin Sherlock
Nature Methods 2, 329–330
(May 2005); doi:10.1038/nmeth0505-329
| Abstract | Full Text (HTML/PDF) |

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