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Research library: browse by date

September 2005

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The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.

Click here for free access to the 'Featured Articles' section, with new articles every week.

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article
GIBBERELLIN INSENSITIVE DWARF1 encodes a soluble receptor for gibberellin
Miyako Ueguchi-Tanaka, Motoyuki Ashikari, Masatoshi Nakajima, Hironori Itoh, Etsuko Katoh, Masatomo Kobayashi, Teh-yuan Chow, Yue-ie C. Hsing, Hidemi Kitano, Isomaro Yamaguchi and Makoto Matsuoka
Nature 437, 693–698
(29 September 2005); doi:10.1038/nature04028
| Abstract | Full Text (HTML / PDF) |

news and views
Plant biology: A receptor for gibberellin
Dario Bonetta and Peter McCourt
Nature 437, 627–628
(29 September 2005); doi:10.1038/437627a
| Full Text (HTML / PDF) |

article
Regulated cell-to-cell variation in a cell-fate decision system
Alejandro Colman-Lerner, Andrew Gordon, Eduard Serra, Tina Chin, Orna Resnekov, Drew Endy, C. Gustavo Pesce and Roger Brent
Nature 437, 699–706
(29 September 2005); doi:10.1038/nature03998
| First Paragraph | Full Text (HTML / PDF) |

letter
Ca2+/calmodulin is critical for brassinosteroid biosynthesis and plant growth
Liqun Du and B. W. Poovaiah
Nature 437, 741–745
(29 September 2005); doi:10.1038/nature03973
| First Paragraph | Full Text (HTML / PDF) |

letter
WntD is a feedback inhibitor of Dorsal/NF-κB in Drosophila development and immunity
Michael D. Gordon, Marc S. Dionne, David S. Schneider and Roel Nusse
Nature 437, 746–749
(29 September 2005); doi:10.1038/nature04073
| First Paragraph | Full Text (HTML / PDF) |

letter
Phosphatidylserine-dependent engulfment by macrophages of nuclei from erythroid precursor cells
Hideyuki Yoshida, Kohki Kawane , Masato Koike, Yoshimi Mori, Yasuo Uchiyama and Shigekazu Nagata
Nature 437, 754–758
(29 September 2005); doi:10.1038/nature03964
| First Paragraph | Full Text (HTML / PDF) |

letter
A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ
Gabriel Pascual, Amy L. Fong, Sumito Ogawa, Amir Gamliel, Andrew C. Li, Valentina Perissi, David W. Rose, Timothy M. Willson, Michael G. Rosenfeld and Christopher K. Glass
Nature 437, 759–763
(29 September 2005); doi:10.1038/nature03988
| First Paragraph | Full Text (HTML / PDF) |

letter
A non-haem iron centre in the transcription factor NorR senses nitric oxide
Benoît D'Autréaux, Nicholas P. Tucker, Ray Dixon and Stephen Spiro
Nature 437, 769–772
(29 September 2005); doi:10.1038/nature03953
| First Paragraph | Full Text (HTML / PDF) |

letter
Listeria hijacks the clathrin-dependent endocytic machinery to invade mammalian cells
Esteban Veiga and Pascale Cossart
Nature Cell Biology 7, 894–900
(September 2005); doi:10.1038/ncb1292
| First Paragraph | Full Text (HTML/PDF) |

letter
Phospho-caveolin-1 mediates integrin-regulated membrane domain internalization
Miguel A. del Pozo, Nagaraj Balasubramanian, Nazilla B. Alderson, William B. Kiosses, Araceli Grande-García, Richard G. W. Anderson and Martin A. Schwartz
Nature Cell Biology 7, 901–908
(September 2005); doi:10.1038/ncb1293
| First Paragraph | Full Text (HTML/PDF) |

review article
The Molecular Repertoire of the 'Almighty' Stem Cell
Craig E. Eckfeldt , Eric M. Mendenhall and Catherine M. Verfaillie
Nature Reviews Molecular Cell Biology 6, 726–737
(September 2005); doi:10.1038/nrm1713
| Abstract | Full Text (HTML / PDF) |

article
The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of drosophila
Catherine Dostert, Emmanuelle Jouanguy, Phil Irving, Laurent Troxler, Delphine Galiana-Arnoux, Charles Hetru, Jules A Hoffmann and Jean-Luc Imler
Nature Immunology 6, 946–953
(September 2005); doi:10.1038/ni1237
| Abstract | Full Text (HTML/PDF) |

news and views
Drosophila innate immunity goes viral
Y Tony Ip
Nature Immunology 6, 863–864
(September 2005); doi:10.1038/ni0905-863
| Full Text (HTML/PDF) |

review article
Regulation of immune cells by local-tissue oxygen tension: HIF1α and adenosine receptors
Michail Sitkovsky and Dmitriy Lukashev
Nature Reviews Immunology 5, 712–721
(September 2005); doi:10.1038/nri1685
Nature Reviews Immunology AOP published online
| Abstract | Full Text (HTML / PDF) |

article
An astrocytic basis of epilepsy
Guo-Feng Tian, Hooman Azmi, Takahiro Takano, Qiwu Xu, Weiguo Peng, Jane Lin, NancyAnn Oberheim, Nanhong Lou, Xiaohai Wang, H Ronald Zielke, Jian Kang and Maiken Nedergaard
Nature Medicine 11, 973–981
(September 2005); doi:10.1038/nm1277
| Abstract | Full Text (HTML/PDF) |

news and views
Astrocytes get in the act in epilepsy
Michael A Rogawski
Nature Medicine 11, 919–920
(September 2005); doi:10.1038/nm0905-919
| Full Text (HTML/PDF) |

review article
The role of autophagy in cancer development and response to therapy
Yasuko Kondo, Takao Kanzawa , Raymond Sawaya and Seiji Kondo
Nature Reviews Cancer 5, 726–734
(September 2005); doi:10.1038/nrc1692
| Abstract | Full Text (HTML / PDF) |

letter
Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway
Jianbo Wang, Sharayne Mark, Xiaohui Zhang, Dong Qian, Seung-Jong Yoo, Kristen Radde-Gallwitz, Yanping Zhang, Xi Lin, Andres Collazo, Anthony Wynshaw-Boris and Ping Chen
Nature Genetics 37, 980–985
(September 2005); doi:10.1038/ng1622
| First Paragraph | Full Text (HTML/PDF) |

brief communication
Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus
Judit K Makara, Marco Mor, Darren Fegley, Szilárd I Szabó, Satish Kathuria, Giuseppe Astarita, Andrea Duranti, Andrea Tontini, Giorgio Tarzia, Silvia Rivara, Tamás F Freund and Daniele Piomelli
Nature Neuroscience 8, 1139–1141
(September 2005); doi:10.1038/nn1521
| First Paragraph | Full Text (HTML/PDF) |

review article
Can we Develop Neurally Acting Drugs for the Treatment of Migraine?
Peter J. Goadsby
Nature Reviews Drug Discovery 4, 741–750
(September 2005); doi:10.1038/nrd1822
| Abstract | Full Text (HTML / PDF) |

article
A streamlined platform for high-content functional proteomics of primary human specimens
Nadim Jessani, Sherry Niessen, BinQing Q Wei, Monica Nicolau, Mark Humphrey, Youngran Ji, Wonshik Han, Dong-Young Noh, John R Yates, III Stefanie S Jeffrey and Benjamin F Cravatt
Nature Methods 2, 691–697
(September 2005); doi:10.1038/nmeth778
| Abstract | Full Text (HTML/PDF) |

article
Model for growth hormone receptor activation based on subunit rotation within a receptor dimer
Richard J Brown, Julian J Adams, Rebecca A Pelekanos, Yu Wan, William J McKinstry, Kathryn Palethorpe, Ruth M Seeber, Thea A Monks, Karin A Eidne, Michael W Parker and Michael J Waters
Nature Structural and Molecular Biology 12, 814–821
(September 2005); doi:10.1038/nsmb977
| Abstract | Full Text (HTML/PDF) |

review article
Pathophysiological consequences of VEGF-induced vascular permeability
Sara M. Weis and David A. Cheresh
Nature 437, 497–504
(22 September 2005); doi:10.1038/nature03987
| Abstract | Full Text (HTML / PDF) |

article
Structures of complement component C3 provide insights into the function and evolution of immunity
Bert J. C. Janssen, Eric G. Huizinga, Hans C. A. Raaijmakers, Anja Roos, Mohamed R. Daha, Kristina Nilsson-Ekdahl, Bo Nilsson and Piet Gros
Nature 437, 505–511
(22 September 2005); doi:10.1038/nature04005
| Abstract | Full Text (HTML / PDF) |

letter
Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation
Ignacio Varela, Juan Cadiñanos, Alberto M. Pendás, Ana Gutiérrez-Fernández, Alicia R. Folgueras, Luis M. Sánchez, Zhongjun Zhou, Francisco J. Rodríguez, Colin L. Stewart, José A Vega, Karl Tryggvason, José M. P. Freije and Carlos López-Otín
Nature 437, 564–568
(22 September 2005); doi:10.1038/nature04019
| First Paragraph | Full Text (HTML / PDF) |

letter
Insulin disrupts β-adrenergic signalling to protein kinase A in adipocytes
Jin Zhang , Christopher J. Hupfeld, Susan S. Taylor, Jerrold M. Olefsky and Roger Y. Tsien
Nature 437, 569–573
(22 September 2005); doi:10.1038/nature04140
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letter
The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways
Kimberly L. Dodge-Kafka, Joseph Soughayer, Genevieve C. Pare, Jennifer J. Carlisle Michel, Lorene K. Langeberg, Michael S. Kapiloff and John D. Scott
Nature 437, 574–578
(22 September 2005); doi:10.1038/nature03966
| First Paragraph | Full Text (HTML / PDF) |

letter
Clusterin inhibits apoptosis by interacting with activated Bax
Honglai Zhang, Jin Koo Kim, Chris A. Edwards, Zhaohui Xu, Russell Taichman and Cun-Yu Wang
Nature Cell Biology 7, 909–915
(September 2005); doi:10.1038/ncb1291
| First Paragraph | Full Text (HTML/PDF) |

review article
Proteomics of organelles and large cellular structures
John R. Yates III, Annalyn Gilchrist, Kathryn E. Howell and John J. M. Bergeron
Nature Reviews Molecular Cell Biology 6, 702–714
(September 2005); doi:10.1038/nrm1711
| Abstract | Full Text (HTML / PDF) |

article
Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance
David E Oppenheim, Scott J Roberts, Sarah L Clarke, Renata Filler, Julie M Lewis, Robert E Tigelaar, Michael Girardi and Adrian C Hayday
Nature Immunology 6, 928–937
(September 2005); doi:10.1038/ni1239
| Abstract | Full Text (HTML/PDF) |

brief communication
PI3Kγ inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus
Domingo F Barber, Almira Bartolomé, Carmen Hernandez, Juana M Flores, Clara Redondo, Cristina Fernandez-Arias, Montserrat Camps, Thomas Rückle, Matthias K Schwarz, Santiago Rodríguez, Carlos Martinez-A, Dimitrios Balomenos, Christian Rommel and Ana C Carrera
Nature Medicine 11, 933–935
(September 2005); doi:10.1038/nm1291
| First Paragraph | Full Text (HTML/PDF) |

article
Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis
Montserrat Camps, Thomas Rückle, Hong Ji, Vittoria Ardissone, Felix Rintelen, Jeffrey Shaw, Chiara Ferrandi, Christian Chabert, Corine Gillieron, Bernard Françon, Thierry Martin, Denise Gretener, Dominique Perrin, Didier Leroy, Pierre-Alain Vitte, Emilio Hirsch, Matthias P Wymann, Rocco Cirillo, Matthias K Schwarz and Christian Rommel
Nature Medicine 11, 936–943
(September 2005); doi:10.1038/nm1284
| Abstract | Full Text (HTML/PDF) |

news and views
Modulating autoimmunity: pick your PI3 kinase
Pamela S Ohashi and James R Woodgett
Nature Medicine 11, 924–925
(September 2005); doi:10.1038/nm0905-924
| Full Text (HTML/PDF) |

letter
Protein accumulation and neurodegeneration in the woozy mutant mouse is caused by disruption of SIL1, a cochaperone of BiP
Lihong Zhao, Chantal Longo-Guess, Belinda S Harris, Jeong-Woong Lee and Susan L Ackerman
Nature Genetics 37, 974–979
(September 2005); doi:10.1038/ng1620
| First Paragraph | Full Text (HTML/PDF) |

letter
Genome-wide analysis of mouse transcripts using exon microarrays and factor graphs
Brendan J Frey, Naveed Mohammad, Quaid D Morris, Wen Zhang, Mark D Robinson, Sanie Mnaimneh, Richard Chang, Qun Pan, Eric Sat, Janet Rossant, Benoit G Bruneau, Jane E Aubin, Benjamin J Blencowe and Timothy R Hughes
Nature Genetics 37, 991–996
(September 2005); doi:10.1038/ng1630
| First Paragraph | Full Text (HTML/PDF) |

article
Nonsynaptic GABA signaling in postnatal subventricular zone controls proliferation of GFAP-expressing progenitors
Xiuxin Liu, Qin Wang, Tarik F Haydar and Angélique Bordey
Nature Neuroscience 8, 1179–1187
(September 2005); doi:10.1038/nn1522
| Abstract | Full Text (HTML/PDF) |

news and views
GABA puts the brake on stem cells
Arnold R Kriegstein
Nature Neuroscience 8, 1132–1133
(September 2005); doi:10.1038/nn0905-1132
| Full Text (HTML/PDF) |

review article
The origin and development of glial cells in peripheral nerves
Kristjan R. Jessen and Rhona Mirsky
Nature Reviews Neuroscience 6, 671–682
(September 2005); doi:10.1038/nrn1746
| Abstract | Full Text (HTML / PDF) |

letter
Overexpression of an Arabidopsis thaliana ABC transporter confers kanamycin resistance to transgenic plants
Ayalew Mentewab, C Neal Stewart and Jr
Nature Biotechnology 23, 1177–1180
(September 2005); doi:10.1038/nbt1134
| First Paragraph | Full Text (HTML/PDF) |

news and views
A farewell to bacterial ARMs?
Philip A Rea
Nature Biotechnology 23, 1085–1087
(September 2005); doi:10.1038/nbt0905-1085
| Full Text (HTML/PDF) |

article
Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1
Handan Kaygun and William F Marzluff
Nature Structural and Molecular Biology 12, 794–800
(September 2005); doi:10.1038/nsmb972
| Abstract | Full Text (HTML/PDF) |

article
Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins
Rainer Zenz, Robert Eferl, Lukas Kenner, Lore Florin, Lars Hummerich, Denis Mehic, Harald Scheuch, Peter Angel, Erwin Tschachler and Erwin F. Wagner
Nature 437, 369–375
(15 September 2005); doi:10.1038/nature03963
| Abstract | Full Text (HTML / PDF) |

letter
WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature
Ivan B. Lobov, Sujata Rao, Thomas J. Carroll, Jefferson E. Vallance, Masataka Ito, Jennifer K. Ondr, Savita Kurup, Donald A. Glass, Millan S. Patel, Weiguo Shu, Edward E. Morrisey, Andrew P. McMahon, Gerard Karsenty and Richard A. Lang
Nature 437, 417–421
(15 September 2005); doi:10.1038/nature03928
| First Paragraph | Full Text (HTML / PDF) |

letter
Membrane vesicles traffic signals and facilitate group activities in a prokaryote
Lauren M. Mashburn and Marvin Whiteley
Nature 437, 422–425
(15 September 2005); doi:10.1038/nature03925
| First Paragraph | Full Text (HTML / PDF) |

letter
A mechanosensory complex that mediates the endothelial cell response to fluid shear stress
Eleni Tzima, Mohamed Irani-Tehrani, William B. Kiosses, Elizabetta Dejana, David A. Schultz, Britta Engelhardt, Gaoyuan Cao, Horace DeLisser and Martin Alexander Schwartz
Nature 437, 426–431
(15 September 2005); doi:10.1038/nature03952
| First Paragraph | Full Text (HTML / PDF) |

letter
An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation
Min Gyu Lee, Christopher Wynder, Neil Cooch and Ramin Shiekhattar
Nature 437, 432–435
(15 September 2005); doi:10.1038/nature04021
| First Paragraph | Full Text (HTML / PDF) |

letter
LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription
Eric Metzger, Melanie Wissmann, Na Yin, Judith M. Müller, Robert Schneider, Antoine H. F. M. Peters, Thomas Günther, Reinhard Buettner and Roland Schüle
Nature 437, 436–439
(15 September 2005); doi:10.1038/nature04020
| First Paragraph | Full Text (HTML / PDF) |

letter
Mesoscale conformational changes in the DNA-repair complex Rad50/Mre11/Nbs1 upon binding DNA
Fernando Moreno-Herrero, Martijn de Jager, Nynke H. Dekker, Roland Kanaar, Claire Wyman and Cees Dekker
Nature 437, 440–443
(15 September 2005); doi:10.1038/nature03927
| First Paragraph | Full Text (HTML / PDF) |

article
PDGFRβ+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival
Steven Song, Andrew J. Ewald, William Stallcup, Zena Werb and Gabriele Bergers
Nature Cell Biology 7, 870–879
(September 2005); doi:10.1038/ncb1288
| Abstract | Full Text (HTML/PDF) |

brief communication
Distinct roles of IκB proteins in regulating constitutive NF-kB activity
Vinay Tergaonkar, Ricardo G Correa, Masahito Ikawa and Inder M Verma
Nature Cell Biology 7, 921–923
(September 2005); doi:10.1038/ncb1296
| First Paragraph | Full Text (HTML/PDF) |

review article
Developmental Cell Biology: G Proteins in Development
Craig C. Malbon
Nature Reviews Molecular Cell Biology 6, 689–701
(September 2005); doi:10.1038/nrm1716
| Abstract | Full Text (HTML / PDF) |

article
Endothelial heparan sulfate deficiency impairs L-selectin- and chemokine-mediated neutrophil trafficking during inflammatory responses
Lianchun Wang, Mark Fuster, P Sriramarao and Jeffrey D Esko
Nature Immunology 6, 902–910
(September 2005); doi:10.1038/ni1233
| Abstract | Full Text (HTML/PDF) |

review article
Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation
Warren J. Leonard and Rosanne Spolski
Nature Reviews Immunology 5, 688–698
(September 2005); doi:10.1038/nri1688
| Abstract | Full Text (HTML / PDF) |

article
A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension
Songling Liu, Richard T Premont, Christopher D Kontos, Shoukang Zhu and Don C Rockey
Nature Medicine 11, 952–958
(September 2005); doi:10.1038/nm1289
| Abstract | Full Text (HTML/PDF) |

article
Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation
Stephen A Back, Therese M F Tuohy, Hanqin Chen, Nicholas Wallingford, Andrew Craig, Jaime Struve, Ning Ling Luo, Fatima Banine, Ying Liu, Ansi Chang, Bruce D Trapp, Bruce F Bebo,, Jr. Mahendra S Rao and Larry S Sherman
Nature Medicine 11, 966–972
(September 2005); doi:10.1038/nm1279
| Abstract | Full Text (HTML/PDF) |

letter
Induction of interleukin-8 preserves the angiogenic response in HIF-1α-deficient colon cancer cells
Yusuke Mizukami, Won-Seok Jo, Eva-Maria Duerr, Manish Gala, Jingnan Li, Xiaobo Zhang, Michael A Zimmer, Othon Iliopoulos, Lawrence R Zukerberg, Yutaka Kohgo, Maureen P Lynch, Bo R Rueda and Daniel C Chung
Nature Medicine 11, 992–997
(September 2005); doi:10.1038/nm1294
| First Paragraph | Full Text (HTML/PDF) |

review article
Urothelial tumorigenesis: a tale of divergent pathways
Xue-Ru Wu
Nature Reviews Cancer 5, 713–725
(September 2005); doi:10.1038/nrc1697
| Abstract | Full Text (HTML / PDF) |

letter
The BRIP1 helicase functions independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repair
Wendy L Bridge, Cassandra J Vandenberg, Roger J Franklin and Kevin Hiom
Nature Genetics 37, 953–957
(September 2005); doi:10.1038/ng1627
| First Paragraph | Full Text (HTML/PDF) |

letter
A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M
Amom Ruhikanta Meetei, Annette L Medhurst, Chen Ling, Yutong Xue, Thiyam Ramsing Singh, Patrick Bier, Jurgen Steltenpool, Stacie Stone, Inderjeet Dokal, Christopher G Mathew, Maureen Hoatlin, Hans Joenje, Johan P de Winter and Weidong Wang
Nature Genetics 37, 958–963
(September 2005); doi:10.1038/ng1626
| First Paragraph | Full Text (HTML/PDF) |

brief communication
The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia
Orna Levran, Claire Attwooll, Rashida T Henry, Kelly L Milton, Kornelia Neveling, Paula Rio, Sat Dev Batish, Reinhard Kalb, Eunike Velleuer, Sandra Barral, Jurg Ott, John Petrini, Detlev Schindler, Helmut Hanenberg and Arleen D Auerbach
Nature Genetics 37, 931–933
(September 2005); doi:10.1038/ng1624
| First Paragraph | Full Text (HTML/PDF) |

brief communication
The DNA helicase BRIP1 is defective in Fanconi anemia complementation group J
Marieke Levitus, Quinten Waisfisz, Barbara C Godthelp, Yne de Vries, Shobbir Hussain, Wouter W Wiegant, Elhaam Elghalbzouri-Maghrani, Jûrgen Steltenpool, Martin A Rooimans, Gerard Pals, Fré Arwert, Christopher G Mathew, Magorzata Z Zdzienicka, Kevin Hiom, Johan P De Winter and Hans Joenje
Nature Genetics 37, 934–935
(September 2005); doi:10.1038/ng1625
| First Paragraph | Full Text (HTML/PDF) |

article
Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells
Rudolf Götz, Stefan Wiese, Shinichi Takayama, Guadalupe C Camarero, Wilfried Rossoll, Ulrich Schweizer, Jakob Troppmair, Sibylle Jablonka, Bettina Holtmann, John C Reed, Ulf R Rapp and Michael Sendtner
Nature Neuroscience 8, 1169–1178
(September 2005); doi:10.1038/nn1524
| Abstract | Full Text (HTML/PDF) |

news and views
Toward a universal multistrain bacterial vaccine
Robert G Feldman
Nature Biotechnology 23, 1087–1088
(September 2005); doi:10.1038/nbt0905-1087
| Full Text (HTML/PDF) |

article
Determination of absolute protein numbers in single synapses by a GFP-based calibration technique
Yoshiko Sugiyama, Izumi Kawabata, Kenji Sobue and Shigeo Okabe
Nature Methods 2, 677–684
(September 2005); doi:10.1038/nmeth783
| Abstract | Full Text (HTML/PDF) |

article
The vertebrate Hef ortholog is a component of the Fanconi anemia tumor-suppressor pathway
Georgina Mosedale, Wojciech Niedzwiedz, Arno Alpi, Franco Perrina, Jose B Pereira-Leal, Mark Johnson, Frederic Langevin, Paul Pace and Ketan J Patel
Nature Structural and Molecular Biology 12, 763–771
(September 2005); doi:10.1038/nsmb981
| Abstract | Full Text (HTML/PDF) |

letter
The most infectious prion protein particles
Jay R. Silveira, Gregory J. Raymond, Andrew G. Hughson, Richard E. Race, Valerie L. Sim, Stanley F. Hayes and Byron Caughey
Nature 437, 257–261
(08 September 2005); doi:10.1038/nature03989
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letter
Prion protein remodelling confers an immediate phenotypic switch
Prasanna Satpute-Krishnan and Tricia R. Serio
Nature 437, 262–265
(08 September 2005); doi:10.1038/nature03981
| First Paragraph | Full Text (HTML / PDF) |

letter
Mutations in NOTCH1 cause aortic valve disease
Vidu Garg, Alecia N. Muth, Joshua F. Ransom, Marie K. Schluterman, Robert Barnes, Isabelle N. King , Paul D. Grossfeld and Deepak Srivastava
Nature 437, 270–274
(08 September 2005); doi:10.1038/nature03940
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letter
Asymmetric cell divisions promote stratification and differentiation of mammalian skin
Terry Lechler and Elaine Fuchs
Nature 437, 275–280
(08 September 2005); doi:10.1038/nature03922
| First Paragraph | Full Text (HTML / PDF) |

letter
Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development
Abdolrahman S. Nateri, Bradley Spencer-Dene and Axel Behrens
Nature 437, 281–285
(08 September 2005); doi:10.1038/nature03914
| First Paragraph | Full Text (HTML / PDF) |

news and views
Synthetic chemistry: Glycosylation with a twist
Sabine L. Flitsch
Nature 437, 201–202
(08 September 2005); doi:10.1038/437201a
| Full Text (HTML / PDF) |

letter
A GTPase-activating protein controls Rab5 function in endocytic trafficking
Alexander K. Haas, Evelyn Fuchs, Robert Kopajtich and Francis A. Barr
Nature Cell Biology 7, 887–893
(September 2005); doi:10.1038/ncb1290
| First Paragraph | Full Text (HTML/PDF) |

news and views
Filling the Rab GAP
Suzanne Pfeffer
Nature Cell Biology 7, 856–857
(September 2005); doi:10.1038/ncb0905-856
| Full Text (HTML/PDF) |

review article
Trashing the genome: the role of nucleases during apoptosis
Kumiko Samejima and William C. Earnshaw
Nature Reviews Molecular Cell Biology 6, 677–688
(September 2005); doi:10.1038/nrm1715
| Abstract | Full Text (HTML / PDF) |

article
Notch promotes survival of pre-T cells at the β-selection checkpoint by regulating cellular metabolism
Maria Ciofani and Juan Carlos Zúñiga-Pflücker
Nature Immunology 6, 881–888
(September 2005); doi:10.1038/ni1234
| Abstract | Full Text (HTML/PDF) |

article
An essential function for the calcium-promoted Ras inactivator in Fcγ receptor-mediated phagocytosis
Jun Zhang, Jian Guo, Ivan Dzhagalov and You-Wen He
Nature Immunology 6, 911–919
(September 2005); doi:10.1038/ni1232
| Abstract | Full Text (HTML/PDF) |

news and views
A CAPRIciously translocating Rac adaptor
Steven Greenberg
Nature Immunology 6, 864–866
(September 2005); doi:10.1038/ni0905-864
| Full Text (HTML/PDF) |

review article
The Yin and Yang of type I interferon activity in bacterial infection
Thomas Decker, Mathias Müller and Silvia Stockinger
Nature Reviews Immunology 5, 675–687
(September 2005); doi:10.1038/nri1684
| Abstract | Full Text (HTML / PDF) |

article
Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation
Xiaofeng Li, Peng Liu, Wenzhong Liu, Peter Maye, Jianghong Zhang, Yazhou Zhang, Marja Hurley, Caiying Guo, Adele Boskey, Le Sun, Stephen E Harris, David W Rowe, Hua Zhu Ke and Dianqing Wu
Nature Genetics 37, 945–952
(September 2005); doi:10.1038/ng1614
| Abstract | Full Text (HTML/PDF) |

letter
Intragenic tandem repeats generate functional variability
Kevin J Verstrepen, An Jansen, Fran Lewitter and Gerald R Fink
Nature Genetics 37, 986–990
(September 2005); doi:10.1038/ng1618
| First Paragraph | Full Text (HTML/PDF) |

review article
Molecular mechanisms of flower development: an armchair guide
Beth A. Krizek and Jennifer C. Fletcher
Nature Reviews Genetics 6, 688–698
(September 2005); doi:10.1038/nrg1675
| Abstract | Full Text (HTML / PDF) |

article
Activation of GPCRs modulates quantal size in chromaffin cells through Gβγ and PKC
Xiao-Ke Chen, Lie-Cheng Wang, Yang Zhou, Qian Cai, Murali Prakriya, Kai-Lai Duan, Zu-Hang Sheng, Christopher Lingle and Zhuan Zhou
Nature Neuroscience 8, 1160–1168
(September 2005); doi:10.1038/nn1529
| Abstract | Full Text (HTML/PDF) |

brief communication
Gene expression profiling in single cells within tissue
Paola Capodieci, Michael Donovan, Heidi Buchinsky, Yusuf Jeffers, Carlos Cordon-Cardo, William Gerald, Jon Edelson, Shailesh M Shenoy and Robert H Singer
Nature Methods 2, 663–665
(September 2005); doi:10.1038/nmeth786
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article
Translation elongation factor 1A is essential for regulation of the actin cytoskeleton and cell morphology
Stephane R Gross and Terri Goss Kinzy
Nature Structural and Molecular Biology 12, 772–778
(September 2005); doi:10.1038/nsmb979
| Abstract | Full Text (HTML/PDF) |

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