The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.
Click here for free access to the 'Featured Articles' section, with new articles every week.
article A haplotype map of the human genome
The International HapMap Consortium Nature437, 1299–1320
(27 October 2005); doi:10.1038/nature04226
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letter Regulation of Lethal giant larvae by Dishevelled
Gretchen L. Dollar, Ursula Weber, Marek Mlodzik and Sergei Y. Sokol Nature437, 1376–1380
(27 October 2005); doi:10.1038/nature04116
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letter A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes
Yuko Hirano, Klavs B. Hendil, Hideki Yashiroda, Shun-ichiro Iemura, Ryoichi Nagane, Yusaku Hioki, Tohru Natsume, Keiji Tanaka and Shigeo Murata Nature437, 1381–1385
(27 October 2005); doi:10.1038/nature04106
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letter The histone H3.3 chaperone HIRA is essential for chromatin assembly in the male pronucleus
Benjamin Loppin, Emilie Bonnefoy, Caroline Anselme, Anne Laurençon, Timothy L. Karr and Pierre Couble Nature437, 1386–1390
(27 October 2005); doi:10.1038/nature04059
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letter Wnt signalling regulates adult hippocampal neurogenesis
Dieter-Chichung Lie, Sophia A. Colamarino, Hong-Jun Song, Laurent Désiré, Helena Mira, Antonella Consiglio, Edward S. Lein, Sebastian Jessberger, Heather Lansford, Alejandro R. Dearie and Fred H. Gage Nature437, 1370–1375
(27 October 2005); doi: 10.1038/nature04108
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news and views Cell biology: Helices sculpt membrane
Guillaume Drin and Bruno Antonny
Many proteins are carried within cells in bubble-like sacs. These are pinched off from membranes inside the cell, and it seems that the Sar1p protein is key in both starting and finishing this budding process. Nature437, 1247–1249
(27 October 2005); doi:10.1038/4371247a
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letter Genetic isolation of transport signals directing cell surface expression
Sojin Shikano, Brian Coblitz, Haiyan Sun and Min Li Nature Cell Biology7, 985–992
(October 2005); doi:10.1038/ncb1297
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letter Neddylation and deneddylation regulate Cul1 and Cul3 protein accumulation
June-Tai Wu, Hsiu-Chen Lin, Yen-Chen Hu and Cheng-Ting Chien Nature Cell Biology7, 1014–1020
(October 2005); doi:10.1038/ncb1301
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article Involvement of caspase-cleaved and intact adaptor protein 1 complex in endosomal remodeling in maturing dendritic cells
Laura Santambrogio, Ilaria Potolicchio, Shawn P Fessler, Siew-Heng Wong, Graça Raposo and Jack L Strominger Nature Immunology6, 1020–1028
(October 2005); doi:10.1038/ni1250
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news and views Dendritic cells: caspases keep them young
Peter E Jensen Nature Immunology6, 968–969
(October 2005); doi:10.1038/ni1005-968
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article BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells
Ryan T Phan, Masumichi Saito, Katia Basso, Huifeng Niu and Riccardo Dalla-Favera Nature Immunology6, 1054–1060
(October 2005); doi:10.1038/ni1245
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news and views A-Miz-ing BCL6
Xiaosheng Wu and Diane F Jelinek Nature Immunology6, 964–966
(October 2005); doi:10.1038/ni1005-964
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article Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms
Rei Shibata, Kaori Sato, David R Pimentel, Yukihiro Takemura, Shinji Kihara, Koji Ohashi, Tohru Funahashi, Noriyuki Ouchi and Kenneth Walsh Nature Medicine11, 1096–1103
(October 2005); doi:10.1038/nm1295
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news and views Fat, keeping the heart healthy?
Koh-ichi Yuhki, Jun-ichi Kawabe and Fumitaka Ushikubi Nature Medicine11, 1048–1049
(October 2005); doi:10.1038/nm1005-1048
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The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis
Rosa A. Cardone, Valeria Casavola and Stephan J. Reshkin Nature Reviews Cancer5, 786–795
(27 October 2005); doi:10.1038/nrc1713
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article XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer
Purificación Muñoz, Raquel Blanco, Juana M Flores and María A Blasco Nature Genetics37, 1063–1071
(October 2005); doi:10.1038/ng1633
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letter A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis
Matthew R Lincoln, Alexandre Montpetit, M Zameel Cader, Janna Saarela, David A Dyment, Milvi Tiislar, Vincent Ferretti, Pentti J Tienari, A Dessa Sadovnick, Leena Peltonen, George C Ebers and Thomas J Hudson Nature Genetics37, 1108–1112
(October 2005); doi:10.1038/ng1647
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letter A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility
David Reich, Nick Patterson, Philip L De Jager, Gavin J McDonald, Alicja Waliszewska, Arti Tandon, Robin R Lincoln, Cari DeLoa, Scott A Fruhan, Philippe Cabre, Odile Bera, Gilbert Semana, M Ann Kelly, David A Francis, Kristin Ardlie, Omar Khan, Bruce A C Cree, Stephen L Hauser, Jorge R Oksenberg and David A Hafler Nature Genetics37, 1113–1118
(October 2005); doi:10.1038/ng1646
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article Regulation of aversion to noxious food by Drosophila neuropeptide Y- and insulin-like systems
Qi Wu, Zhangwu Zhao and Ping Shen Nature Neuroscience8, 1350–1355
(October 2005); doi:10.1038/nn1540
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article Trapped in action: direct visualization of DNA methyltransferase activity in living cells
Lothar Schermelleh, Fabio Spada, Hariharan P Easwaran, Kourosh Zolghadr, Jean B Margot, M Cristina Cardoso and Heinrich Leonhardt Nature Methods8, 751–756
(October 2005); doi:10.1038/nmeth794
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news and views In living color: DNA methyltransferase caught in the act
Kornel Schuebel and Steve Baylin Nature Methods2, 736–738
(October 2005); doi:10.1038/nmeth1005-736
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article The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism
Seung-Hoi Koo, Lawrence Flechner, Ling Qi, Xinmin Zhang, Robert A. Screaton, Shawn Jeffries, Susan Hedrick, Wu Xu, Fayçal Boussouar, Paul Brindle, Hiroshi Takemori and Marc Montminy Nature437, 1109–11
(20 October 2005); doi:10.1038/nature03967
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article Rebuilt AAA + motors reveal operating principles for ATP-fuelled machines
Andreas Martin, Tania A. Baker and Robert T. Sauer Nature437, 1115–1120
(20 October 2005); doi:10.1038/nature04031
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letter Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
Etienne Meylan, Joseph Curran, Kay Hofmann, Darius Moradpour, Marco Binder, Ralf Bartenschlager and Jürg Tschopp Nature437, 1167–1172
(20 October 2005); doi:10.1038/nature04193
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letter Towards a proteome-scale map of the human protein-protein interaction network
Jean-François Rual, Kavitha Venkatesan, Tong Hao, Tomoko Hirozane-Kishikawa, Amélie Dricot, Ning Li, Gabriel F. Berriz, Francis D. Gibbons, Matija Dreze, Nono Ayivi-Guedehoussou, Niels Klitgord, Christophe Simon, Mike Boxem, Stuart Milstein, Jennifer Rosenberg, Debra S. Goldberg, Lan V. Zhang, Sharyl L. Wong, Giovanni Franklin, Siming Li, Joanna S. Albala, Janghoo Lim, Carlene Fraughton, Estelle Llamosas, Sebiha Cevik, Camille Bex, Philippe Lamesch, Robert S. Sikorski, Jean Vandenhaute, Huda Y. Zoghbi, Alex Smolyar, Stephanie Bosak, Reynaldo Sequerra, Lynn Doucette-Stamm, Michael E. Cusick, David E. Hill, Frederick P. Roth and Marc Vidal Nature437, 1173–1178
(20 October 2005); doi:10.1038/nature04209
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letter Photosystem II core phosphorylation and photosynthetic acclimation require two different protein kinases
Vera Bonardi, Paolo Pesaresi, Thomas Becker, Enrico Schleiff, Raik Wagner, Thomas Pfannschmidt, Peter Jahns and Dario Leister Nature437, 1179–1182
(20 October 2005); doi:10.1038/nature04016
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news and views Cell biology: A BID for the pathway
Michael B. Kastan Nature437, 1103
(20 October 2005); doi:10.1038/4371103a
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letter Ubx2 links the Cdc48 complex to ER-associated protein degradation
Oliver Neuber, Ernst Jarosch, Corinna Volkwein, Jan Walter and Thomas Sommer Nature Cell Biology7, 993–998
(October 2005); doi:10.1038/ncb1298
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letter Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation
Christian Schuberth and Alexander Buchberger Nature Cell Biology7, 999–1006
(October 2005); doi:10.1038/ncb1299
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review article Developmental Cell Biology: C. elegans cell cycles: invariance and stem cell divisions
Edward T. Kipreos Nature Reviews Molecular Cell Biology6, 766–776
(October 2005); doi:10.1038/nrm1738
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article Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor
Romain Roncagalli, James E R Taylor, Shaohua Zhang, Xiaochu Shi, Riyan Chen, Mario-Ernesto Cruz-Munoz, Luo Yin, Sylvain Latour and André Veillette Nature Immunology6, 1002–1010
(October 2005); doi:10.1038/ni1242
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news and views Fine-tuning NK cell responses: it's a family affair
Marco Colonna Nature Immunology6, 961–962
(October 2005); doi:10.1038/ni1005-961
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review article Regulation of MHC class II gene expression by the class II transactivator
Walter Reith, Salomé LeibundGut-Landmann and Jean-Marc Waldburger Nature Reviews Immunology5, 793–806
(October 2005); doi:10.1038/nri1708
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article 17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration
Masahiro Waza, Hiroaki Adachi, Masahisa Katsuno, Makoto Minamiyama, Chen Sang, Fumiaki Tanaka, Akira Inukai, Manabu Doyu and Gen Sobue Nature Medicine11, 1088–1095
(October 2005); doi:10.1038/nm1298
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letter Genomic alterations in cultured human embryonic stem cells
Anirban Maitra, Dan E Arking, Narayan Shivapurkar, Morna Ikeda, Victor Stastny, Keyaunoosh Kassauei, Guoping Sui, David J Cutler, Ying Liu, Sandii N Brimble, Karin Noaksson, Johan Hyllner, Thomas C Schulz, Xianmin Zeng, William J Freed, Jeremy Crook, Suman Abraham, Alan Colman, Peter Sartipy, Sei-Ichi Matsui, Melissa Carpenter, Adi F Gazdar, Mahendra Rao and Aravinda Chakravarti Nature Genetics37, 1099–1103
(October 2005); doi:10.1038/ng1631
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brief communication Homozygous HOXA1 mutations disrupt human brainstem, inner ear, cardiovascular and cognitive development
Max A Tischfield, Thomas M Bosley, Mustafa A M Salih, Ibrahim A Alorainy, Emin C Sener, Michael J Nester, Darren T Oystreck, Wai-Man Chan, Caroline Andrews, Robert P Erickson and Elizabeth C Engle Nature Genetics37, 1035–1037
(October 2005); doi:10.1038/ng1636
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review article The new cytogenetics: blurring the boundaries with molecular biology
Michael R. Speicher and Nigel P. Carter Nature Reviews Genetics6, 782–792
(October 2005); doi:10.1038/nrg1692
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article Patterned expression of Purkinje cell glutamate transporters controls synaptic plasticity
Jacques I Wadiche and Craig E Jahr Nature Neuroscience8, 1329–1334
(October 2005); doi:10.1038/nn1539
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research article Generation of functional ion-channel tools by E3 targeting
Shang-Zhong Xu, Fanning Zeng, Ming Lei, Jing Li, Bin Gao, Chenliang Xiong, Asipu Sivaprasadarao and David J Beech Nature Biotechnology23, 1289–1293
(October 2005); doi:10.1038/nbt1148
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news and views Simple recipe for blocking ion channels
Christopher D Benham Nature Biotechnology23, 1234–1235
(October 2005); doi:10.1038/nbt1005-1234
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article The N-end rule pathway as a nitric oxide sensor controlling the levels of multiple regulators
Rong-Gui Hu, Jun Sheng, Xin Qi, Zhenming Xu, Terry T. Takahashi and Alexander Varshavsky Nature437, 981–986
(13 October 2005); doi:10.1038/nature04027
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letter Vertebrate Smoothened functions at the primary cilium
Kevin C. Corbit, Pia Aanstad , Veena Singla, Andrew R. Norman, Didier Y. R. Stainier and Jeremy F. Reiter Nature437, 1018–1021
(13 October 2005); doi:10.1038/nature04117
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letter SERRATE coordinates shoot meristem function and leaf axial patterning in Arabidopsis
Stephen P. Grigg, Claudia Canales, Angela Hay and Miltos Tsiantis Nature437, 1022–1026
(13 October 2005); doi:10.1038/nature04052
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letter A network-based analysis of systemic inflammation in humans
Steve E. Calvano, Wenzhong Xiao, Daniel R. Richards, Ramon M. Felciano, Henry V. Baker, Raymond J. Cho, Richard O. Chen, Bernard H. Brownstein, J. Perren Cobb, S. Kevin Tschoeke, Carol Miller-Graziano, Lyle L. Moldawer, Michael N. Mindrinos, Ronald W. Davis, Ronald G. Tompkins, Stephen F. Lowry and Inflamm and Host Response to Injury Large Scale Collab. Res. Program Nature437, 1032–1037
(13 October 2005); doi:10.1038/nature03985
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letter Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells
Takeshi Fujiwara, Madhavi Bandi, Masayuki Nitta, Elena V. Ivanova, Roderick T. Bronson and David Pellman Nature437, 1043–1047
(13 October 2005); doi:10.1038/nature04217
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letter Calcium triggers exit from meiosis II by targeting the APC/C inhibitor XErp1 for degradation
Nadine R. Rauh, Andreas Schmidt, Jenny Bormann, Erich A. Nigg and Thomas U. Mayer Nature437, 1048–1052
(13 October 2005); doi:10.1038/nature04093
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letter Solution structure of a protein denatured state and folding intermediate
T. L. Religa, J. S. Markson, U. Mayor, S. M. V. Freund and A. R. Fersht Nature437, 1053–1056
(13 October 2005); doi:10.1038/nature04054
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letter Retraction: RNA-interference-directed chromatin modification coupled to RNA polymerase II transcription
Vera Schramke, Daniel M. Sheedy, Ahmet M. Denli, Carolina Bonila, Karl Ekwall, Gregory J. Hannon and Robin C. Allshire Nature437, 1057
(13 October 2005); doi:10.1038/nature04181
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news and views Developmental biology: Cell cycle unleashed
Takeo Kishimoto Nature437, 963–965
(13 October 2005); doi:10.1038/437963a
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letter Microtubule-dependent microtubule nucleation based on recruitment of γ-tubulin in higher plants
Takashi Murata, Seiji Sonobe, Tobias I. Baskin, Susumu Hyodo, Seiichiro Hasezawa, Toshiyuki Nagata, Tetsuya Horio and Mitsuyasu Hasebe Nature Cell Biology7, 961–968
(October 2005); doi:10.1038/ncb1306
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news and views How and Y plant microtubules branch
Richard Cyr Nature Cell Biology7, 927–929
(October 2005); doi:10.1038/ncb1005-927
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letter Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes
Metello Innocenti, Silke Gerboth, Klemens Rottner, Frank P. L. Lai, Maud Hertzog, Theresia E. B. Stradal, Emanuela Frittoli, Dominique Didry, Simona Polo, Andrea Disanza, Stefanie Benesch, Pier Paolo Di Fiore, Marie-France Carlier and Giorgio Scita Nature Cell Biology7, 969–976
(October 2005); doi:10.1038/ncb1304
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letter Abi activates WASP to promote sensory organ development
Sven Bogdan, Raiko Stephan, Christian Löbke, Alexandra Mertens and Christian Klämbt Nature Cell Biology7, 977–984
(October 2005); doi:10.1038/ncb1305
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article Carbohydrate-binding molecules inhibit viral fusion and entry by crosslinking membrane glycoproteins
Eugenia Leikina, Helene Delanoe-Ayari, Kamran Melikov, Myoung-Soon Cho, Andrew Chen, Alan J Waring, Wei Wang, Yongming Xie, Joseph A Loo, Robert I Lehrer and Leonid V Chernomordik Nature Immunology6, 995–1001
(October 2005); doi:10.1038/ni1248
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news and views Back to the past: new drugs from ancient molecules?
Rodney Phillips Nature Immunology6, 963–964
(October 2005); doi:10.1038/ni1005-963
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review article Cell-surface enzymes in control of leukocyte trafficking
Marko Salmi and Sirpa Jalkanen Nature Reviews Immunology5, 760–771
(October 2005); doi:10.1038/nri1705
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article Tumor-targeted, systemic delivery of therapeutic viral vectors using hitchhiking on antigen-specific T cells
Caroline Cole, Jian Qiao, Timothy Kottke, Rosa Maria Diaz, Atique Ahmed, Luis Sanchez-Perez, Gregory Brunn, Jill Thompson, John Chester and Richard G Vile Nature Medicine11, 1073–1081
(October 2005); doi:10.1038/nm1297
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news and views Hitchhiker's guide to the T cell
Cliona M Rooney Nature Medicine11, 1051–1052
(October 2005); doi:10.1038/nm1005-1051
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news and views Targeting toxic proteins for turnover
Albert R La Spada and Patrick Weydt Nature Medicine11, 1052–1053
(October 2005); doi:10.1038/nm1005-1052
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review article The multiple uses of fluorescent proteins to visualize cancer in vivo
Robert M. Hoffman Nature Reviews Cancer5, 796–806
(October 2005); doi:10.1038/nrc1717
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article Apoptosis induced by vitamin A signaling is crucial for connecting the ureters to the bladder
Ekatherina Batourina, Sheaumei Tsai, Sarah Lambert, Preston Sprenkle, Renata Viana, Sonia Dutta, Terry Hensle, Fengwei Wang, Karen Niederreither, Andrew P McMahon, Thomas J Carroll and Cathy L Mendelsohn Nature Genetics37, 1082–1089
(October 2005); doi:10.1038/ng1645
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article SFRP1 regulates the growth of retinal ganglion cell axons through the Fz2 receptor
Josana Rodriguez, Pilar Esteve, Christine Weinl, José María Ruiz, Yasmín Fermin, Françoise Trousse, Asha Dwivedy, Christine Holt and Paola Bovolenta Nature Neuroscience8, 1301–1309
(October 2005); doi:10.1038/nn1547
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news and views A no-Wnt situation: SFRPs as axon guidance molecules
Uwe Drescher Nature Neuroscience8, 1281–1282
(October 2005); doi:10.1038/nn1005-1281
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research article A human β-cell line for transplantation therapy to control type 1 diabetes
Michiki Narushima, Naoya Kobayashi, Teru Okitsu, Yoshihito Tanaka, Shun-Ai Li, Yong Chen, Atsushi Miki, Kimiaki Tanaka, Shuhei Nakaji, Kohji Takei, Alejandro Soto Gutierrez, Jorge David Rivas-Carrillo, Nalu Navarro-Álvarez, Hee-Sook Jun, Karen A Westerman, Hirofumi Noguchi, Jonathan R T Lakey, Philippe Leboulch, Noriaki Tanaka and Ji-Won Yoon Nature Biotechnology23, 1274–1282
(October 2005); doi:10.1038/nbt1145
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news and views Islets for all?
Hans E Hohmeier and Christopher B Newgard Nature Biotechnology23, 1231–1232
(October 2005); doi:10.1038/nbt1005-1231
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article Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans
Nieng Yan, Jijie Chai, Eui Seung Lee, Lichuan Gu, Qun Liu, Jiaqing He, Jia-Wei Wu, David Kokel, Huilin Li, Quan Hao, Ding Xue and Yigong Shi Nature437, 831–837
(06 October 2005); doi:10.1038/nature04002
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letter In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog
Sohyun Ahn and Alexandra L. Joyner Nature437, 894–897
(06 October 2005); doi:10.1038/nature03994
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letter STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane
Shenyuan L. Zhang, Ying Yu, Jack Roos, J. Ashot Kozak, Thomas J. Deerinck, Mark H. Ellisman, Kenneth A. Stauderman and Michael D. Cahalan Nature437, 902–905
(06 October 2005); doi:10.1038/nature04147
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letter Apolipoprotein-mediated pathways of lipid antigen presentation
Peter van den Elzen, Salil Garg, Luis León, Manfred Brigl, Elizabeth A. Leadbetter, Jenny E. Gumperz, Chris C. Dascher, Tan-Yun Cheng, Frank M. Sacks, Petr A. Illarionov, Gurdyal S. Besra, Sally C. Kent, D. Branch Moody and Michael B. Brenner Nature437, 906–910
(06 October 2005); doi:10.1038/nature04001
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article The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome
Elena N. Pugacheva and Erica A. Golemis Nature Cell Biology7, 937–946
(October 2005); doi:10.1038/ncb1309
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letter The extracellular matrix guides the orientation of the cell division axis
Manuel Théry, Victor Racine, Anne Pépin, Matthieu Piel, Yong Chen, Jean-Baptiste Sibarita and Michel Bornens Nature Cell Biology7, 947–953
(October 2005); doi:10.1038/ncb1307
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letter The endoplasmic reticulum gateway to apoptosis by Bcl-XL modulation of the InsP3R
Carl White, Chi Li, Jun Yang, Nataliya B. Petrenko, Muniswamy Madesh, Craig B. Thompson and J. Kevin Foskett Nature Cell Biology7, 1021–1028
(October 2005); doi:10.1038/ncb1302
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news and views Fog shapes up myosin for gastrulation Nature Cell Biology7, 935
(October 2005); doi:10.1038/ncb1005-935
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review article Tetraspanin functions and associated microdomains
Martin E. Hemler Nature Reviews Molecular Cell Biology6, 801–811
(October 2005); doi:10.1038/nrm1736
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article IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
Taro Kawai, Ken Takahashi, Shintaro Sato, Cevayir Coban, Himanshu Kumar, Hiroki Kato, Ken J Ishii, Osamu Takeuchi and Shizuo Akira Nature Immunology6, 981–988
(October 2005); doi:10.1038/ni1243
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article Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice
Baohua Zhou, Michael R Comeau, Thibaut De Smedt, H Denny Liggitt, Martin E Dahl, David B Lewis, Dora Gyarmati, Theingi Aye, Daniel J Campbell and Steven F Ziegler Nature Immunology6, 1047–1053
(October 2005); doi:10.1038/ni1247
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news and views 'PPAR'ting ways with inflammation
Shannon T Bailey and Sankar Ghosh Nature Immunology6, 966–967
(October 2005); doi:10.1038/ni1005-966
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review article NF-κB: linking inflammation and immunity to cancer development and progression
Michael Karin and Florian R. Greten Nature Reviews Immunology5, 749–759
(October 2005); doi:10.1038/nri1703
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article Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors
Guo-Min Deng, Lixin Zheng, Francis Ka-Ming Chan and Michael Lenardo Nature Medicine11, 1066–1072
(October 2005); doi:10.1038/nm1304
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letter Cdk5-dependent regulation of glucose-stimulated insulin secretion
Fan-Yan Wei, Kazuaki Nagashima, Toshio Ohshima, Yasunori Saheki, Yun-Fei Lu, Masayuki Matsushita, Yuichiro Yamada, Katsuhiko Mikoshiba, Yutaka Seino, Hideki Matsui and Kazuhito Tomizawa Nature Medicine11, 1104–1108
(October 2005); doi:10.1038/nm1299
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article Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity
Natasha L Harvey, R Sathish Srinivasan, Miriam E Dillard, Nicole C Johnson, Marlys H Witte, Kelli Boyd, Mark W Sleeman and Guillermo Oliver Nature Genetics37, 1072–1081
(October 2005); doi:10.1038/ng1642
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news and views Lymph makes you fat
Martin Schneider, Edward M Conway and Peter Carmeliet Nature Genetics37, 1023–1024
(October 2005); doi:10.1038/ng1005-1023
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letter Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster
Emmanuel Caussinus and Cayetano Gonzalez Nature Genetics37, 1125–1129
(October 2005); doi:10.1038/ng1632
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news and views Stem cells, asymmetric division and cancer
Hans Clevers Nature Genetics37, 1027–1028
(October 2005); doi:10.1038/ng1005-1027
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review article The role of chromatin structure in regulating the expression of clustered genes
Duncan Sproul, Nick Gilbert and Wendy A. Bickmore Nature Reviews Genetics6, 775–781
(October 2005); doi:10.1038/nrg1688
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article Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model
Oded Singer, Robert A Marr, Edward Rockenstein, Leslie Crews, Nicole G Coufal, Fred H Gage, Inder M Verma and Eliezer Masliah Nature Neuroscience8, 1343–1349
(October 2005); doi:10.1038/nn1531
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review article Metabotropic glutamate receptors in the basal ganglia motor circuit
P. Jeffrey Conn, Giuseppe Battaglia, Michael J. Marino and Ferdinando Nicoletti Nature Reviews Neuroscience6, 787–798
(October 2005); doi:10.1038/nrn1763
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article Caspase-specific and nonspecific in vivo protein processing during Fas-induced apoptosis
Petra Van Damme, Lennart Martens, Jozef Van Damme, Koen Hugelier, An Staes, Joël Vandekerckhove and Kris Gevaert Nature Methods2, 771–777
(October 2005); doi:10.1038/nmeth792
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brief communication Molecular dynamics imaging in micropatterned living cells
Kristiana Kandere-Grzybowska, Christopher Campbell, Yulia Komarova, Bartosz A Grzybowski and Gary G Borisy Nature Methods2, 739–741
(October 2005); doi:10.1038/nmeth796
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