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Research library: browse by date

November 2005

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The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.

Click here for free access to the 'Featured Articles' section, with new articles every week.

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letter
Direct observation of base-pair stepping by RNA polymerase
Elio A. Abbondanzieri, William J. Greenleaf, Joshua W. Shaevitz, Robert Landick and Steven M. Block
Nature 438, 460–465
(24 November 2005); doi:10.1038/nature04268
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Design principles of a bacterial signalling network
Markus Kollmann, Linda Løvdok, Kilian Bartholomé, Jens Timmer and Victor Sourjik
Nature 438, 504–507
(24 November 2005); doi:10.1038/nature04228
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The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation
Uttiya Basu, Jayanta Chaudhuri , Craig Alpert, Shilpee Dutt, Sheila Ranganath, Gang Li, Jason Patrick Schrum, John P. Manis and Frederick W. Alt
Nature 438, 508–511
(24 November 2005); doi:10.1038/nature04255
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Spatial regulation of β-actin translation by Src-dependent phosphorylation of ZBP1
Stefan Hüttelmaier, Daniel Zenklusen, Marcell Lederer, Jason Dictenberg, Mike Lorenz, XiuHua Meng, Gary J. Bassell, John Condeelis and Robert H. Singer
Nature 438, 512–515
(24 November 2005); doi:10.1038/nature04115
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Structures of ParB bound to DNA reveal mechanism of partition complex formation
Maria A. Schumacher and Barbara E. Funnell
Nature 438, 516–519
(24 November 2005); doi:10.1038/nature04149
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news and views
Obesity: Aquaporin enters the picture
Gema Frühbeck
Nature 438, 436–437
(24 November 2005); doi:10.1038/438436b
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Phosphatidylinositol transfer protein-α in netrin-1-induced PLC signalling and neurite outgrowth
Yi Xie, Yu-Qiang Ding, Yan Hong, Zhu Feng, Sammy Navarre, Cai-Xia Xi, Xiao-Juan Zhu, Chun-Lei Wang, S. L. Ackerman, David Kozlowski, Lin Mei and Wen-Cheng Xiong
Nature Cell Biology 7, 1124–1132
(November 2005); doi:10.1038/ncb1321
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news and views
Netrin PIPes up
Patrick Mehlen and Agnès Bernet
Nature Cell Biology 7, 1052–1053
(November 2005); doi:10.1038/ncb1105-1052
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review article
Prion domains: sequences, structures and interactions
Eric D. Ross, Allen Minton and Reed B. Wickner
Nature Cell Biology 7, 1039–1044
(November 2005); doi:10.1038/ncb1105-1039
| Abstract | Full Text (HTML/PDF) |

article
Essential function for the kinase TAK1 in innate and adaptive immune responses
Shintaro Sato, Hideki Sanjo, Kiyoshi Takeda, Jun Ninomiya-Tsuji, Masahiro Yamamoto, Taro Kawai, Kunihiro Matsumoto, Osamu Takeuchi and Shizuo Akira
Nature Immunology 6, 1087–1095
(November 2005); doi:10.1038/ni1255
| Abstract | Full Text (HTML/PDF) |

article
Maintenance of B cell anergy requires constant antigen receptor occupancy and signaling
Stephen B Gauld, Robert J Benschop, Kevin T Merrell and John C Cambier
Nature Immunology 6, 1160–1167
(November 2005); doi:10.1038/ni1256
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article
The initiation of antigen-induced B cell antigen receptor signaling viewed in living cells by fluorescence resonance energy transfer
Pavel Tolar, Hae Won Sohn and Susan K Pierce
Nature Immunology 6, 1168–1176
(November 2005); doi:10.1038/ni1262
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news and views
Unraveling B cell receptor mechanics
Jürgen Wienands
Nature Immunology 6, 1072–1074
(November 2005); doi:10.1038/ni1105-1072
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review article
Molecular defects in T- and B-cell primary immunodeficiency diseases
Charlotte Cunningham-Rundles and Prashant P. Ponda
Nature Reviews Immunology 5, 880–892
(November 2005); doi:10.1038/nri1713
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article
Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo
Juhua Chen, Payaningal R Somanath, Olga Razorenova, William S Chen, Nissim Hay, Paul Bornstein and Tatiana V Byzova
Nature Medicine 11, 1188–1196
(November 2005); doi:10.1038/nm1307
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article
Sonic hedgehog myocardial gene therapy: tissue repair through transient reconstitution of embryonic signaling
Kengo F Kusano, Roberto Pola, Toshinori Murayama, Cynthia Curry, Atsuhiko Kawamoto, Atsushi Iwakura, Satoshi Shintani, Masaaki Ii, Jun Asai, Tengiz Tkebuchava, Tina Thorne, Hideya Takenaka, Ryuichi Aikawa, David Goukassian, Patrick von Samson, Hiromichi Hamada, Young-sup Yoon, Marcy Silver, Elizabeth Eaton, Hong Ma, Lindsay Heyd, Marianne Kearney, William Munger, Jeffery A Porter, Raj Kishore and Douglas W Losordo
Nature Medicine 11, 1197–1204
(November 2005); doi:10.1038/nm1313
| Abstract | Full Text (HTML/PDF) |

review article
Lysosomes and autophagy in cell death control
Guido Kroemer and Marja Jäättelä
Nature Reviews Cancer 5, 886–897
(November 2005); doi:10.1038/nrc1738
| Summary | Full Text (HTML / PDF) |

letter
Negative epistasis between the malaria-protective effects of α+-thalassemia and the sickle cell trait
Thomas N Williams, Tabitha W Mwangi, Sammy Wambua, Timothy E A Peto, David J Weatherall, Sunetra Gupta, Mario Recker, Bridget S Penman, Sophie Uyoga, Alex Macharia, Jedidah K Mwacharo, Robert W Snow and Kevin Marsh
Nature Genetics 37, 1253–1257
(November 2005); doi:10.1038/ng1660
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review article
Genotyping errors: causes, consequences and solutions
François Pompanon, Aurélie Bonin, Eva Bellemain and Pierre Taberlet
Nature Reviews Genetics 6, 847–846
(November 2005); doi:10.1038/nrg1707
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news and views
Senseless makes sense for spinocerebellar ataxia-1
Vikram Khurana, Tudor A Fulga and Mel B Feany
Nature Neuroscience 8, 1422–1424
(November 2005); doi:10.1038/nn1105-1422
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review article
Axon degeneration mechanisms: commonality amid diversity
Michael Coleman
Nature Reviews Neuroscience 6, 889–898
(November 2005); doi:10.1038/nrn1788
| Summary | Full Text (HTML / PDF) |

article
Structure of the E. coli protein-conducting channel bound to a translating ribosome
Kakoli Mitra, Christiane Schaffitzel, Tanvir Shaikh, Florence Tama, Simon Jenni, Charles L. Brooks III, Nenad Ban and Joachim Frank
Nature 438, 318–324
(17 November 2005); doi:10.1038/nature04133
| Summary | Full Text (HTML / PDF) |

news and views
Cell biology: Two pores better than one?
Arnold J. M. Driessen
Nature 438, 299–300
(17 November 2005); doi:10.1038/438299a
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article
A light-sensing knot revealed by the structure of the chromophore-binding domain of phytochrome
Jeremiah R. Wagner, Joseph S. Brunzelle, Katrina T. Forest and Richard D. Vierstra
Nature 438, 325–331
(17 November 2005); doi:10.1038/nature04118
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Specification of astrocytes by bHLH protein SCL in a restricted region of the neural tube
Yuko Muroyama, Yuko Fujiwara, Stuart H. Orkin and David H. Rowitch
Nature 438, 360–363
(17 November 2005); doi:10.1038/nature04139
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Control of B-cell responses by Toll-like receptors
Chandrashekhar Pasare and Ruslan Medzhitov
Nature 438, 364–368
(17 November 2005); doi:10.1038/nature04267
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Evidence for de novo imprinted X-chromosome inactivation independent of meiotic inactivation in mice
Ikuhiro Okamoto, Danielle Arnaud, Patricia Le Baccon, Arie P. Otte, Christine M. Disteche, Philip Avner and Edith Heard
Nature 438, 369–373
(17 November 2005); doi:10.1038/nature04155
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A histone H3 methyltransferase controls epigenetic events required for meiotic prophase
Katsuhiko Hayashi , Kayo Yoshida and Yasuhisa Matsui
Nature 438, 374–378
(17 November 2005); doi:10.1038/nature04112
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Chromatin remodelling at a DNA double-strand break site in Saccharomyces cerevisiae
Toyoko Tsukuda, Alastair B. Fleming, Jac A. Nickoloff and Mary Ann Osley
Nature 438, 379–383
(17 November 2005); doi:10.1038/nature04148
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article
Distinct enzyme combinations in AKAP signalling complexes permit functional diversity
Naoto Hoshi, Lorene K. Langeberg and John D. Scott
Nature Cell Biology 7, 1066–1073
(November 2005); doi:10.1038/ncb1315
| Abstract | Full Text (HTML/PDF) |

news and views
A-kinase anchoring proteins: different partners, different dance
Lei Chen and Robert S. Kass
Nature Cell Biology 7, 1050–1051
(November 2005); doi:10.1038/ncb1105-1050
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news and views
Autophagy: to die or not to die
Myrto Raftopoulou
Nature Cell Biology 7, 1056
(November 2005); doi:10.1038/ncb1105-1056
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review article
Developmental cell biology: Regulatory networks in embryo-derived pluripotent stem cells
Michele Boiani and Hans R. Schöler
Nature Reviews Molecular Cell Biology 6, 872–881
(November 2005); doi:10.1038/nrm1744
| Summary | Full Text (HTML / PDF) |

article
Essential function for the kinase TAK1 in innate and adaptive immune responses
Shintaro Sato, Hideki Sanjo, Kiyoshi Takeda, Jun Ninomiya-Tsuji, Masahiro Yamamoto, Taro Kawai, Kunihiro Matsumoto, Osamu Takeuchi and Shizuo Akira
Nature Immunology 6, 1087–1095
(November 2005); doi:10.1038/ni1255
| Abstract | Full Text (HTML/PDF) |

review article
Follicular B helper T cells in antibody responses and autoimmunity
Carola G. Vinuesa, Stuart G. Tangye, Bernhard Moser and Charles R. Mackay
Nature Reviews Immunology 5, 853–865
(November 2005); doi:10.1038/nri1714
| Summary | Full Text (HTML / PDF) |

article
Regulation of lung injury and repair by Toll-like receptors and hyaluronan
Dianhua Jiang, Jiurong Liang, Juan Fan, Shuang Yu, Suping Chen, Yi Luo, Glenn D Prestwich, Marcella M Mascarenhas, Hari G Garg, Deborah A Quinn, Robert J Homer, Daniel R Goldstein, Richard Bucala, Patty J Lee, Ruslan Medzhitov and Paul W Noble
Nature Medicine 11, 1173–1179
(November 2005); doi:10.1038/nm1315
| Abstract | Full Text (HTML/PDF) |

news and views
TLRs play good cop, bad cop in the lung
Luke A J O'Neill
Nature Medicine 11, 1161–1162
(November 2005); doi:10.1038/nm1105-1161
| Full Text (HTML/PDF) |

review article
Promoting apoptosis as a strategy for cancer drug discovery
Stephen W. Fesik
Nature Reviews Cancer 5, 876–885
(November 2005); doi:10.1038/nrc1736
| Summary | Full Text (HTML / PDF) |

article
Genetic variation in selenoprotein S influences inflammatory response
Joanne E Curran, Jeremy B M Jowett, Kate S Elliott, Yuan Gao, Kristi Gluschenko, Jianmin Wang, Dalia M Abel Azim, Guowen Cai, Michael C Mahaney, Anthony G Comuzzie, Thomas D Dyer, Ken R Walder, Paul Zimmet, Jean W MacCluer, Greg R Collier, Ahmed H Kissebah and John Blangero
Nature Genetics 37, 1234–1241
(November 2005); doi:10.1038/ng1655
| Abstract | Full Text (HTML/PDF) |

letter
Monovalent cation leaks in human red cells caused by single amino-acid substitutions in the transport domain of the band 3 chloride-bicarbonate exchanger, AE1
Lesley J Bruce, Hannah C Robinson, Hélène Guizouarn, Franck Borgese, Penny Harrison, May-Jean King, Jeroen S Goede, Suzanne E Coles, Daniel M Gore, Hans U Lutz, Romina Ficarella, D Mark Layton, Achille Iolascon, J Clive Ellory and Gordon W Stewart
Nature Genetics 37, 1258–1263
(November 2005); doi:10.1038/ng1656
| First Paragraph | Full Text (HTML/PDF) |

review article
Building the mammalian heart from two sources of myocardial cells
Margaret Buckingham, Sigolène Meilhac and Stéphane Zaffran
Nature Reviews Genetics 6, 826–837
(November 2005); doi:10.1038/nrg1710
| Summary | Full Text (HTML / PDF) |

article
Drosophila melanogaster homolog of Down syndrome critical region 1 is critical for mitochondrial function
Karen T Chang and Kyung-Tai Min
Nature Neuroscience 8, 1577–1585
(November 2005); doi:10.1038/nn1564
| Abstract | Full Text (HTML/PDF) |

article
Evanescent-field fluorescence-assisted lectin microarray: a new strategy for glycan profiling
Atsushi Kuno, Noboru Uchiyama, Shiori Koseki-Kuno, Youji Ebe, Seigo Takashima, Masao Yamada and Jun Hirabayashi
Nature Methods 2, 851–856
(November 2005); doi:10.1038/nmeth803
| Abstract | Full Text (HTML/PDF) |

article
Subunit arrangement and function in NMDA receptors
Hiroyasu Furukawa, Satinder K Singh, Romina Mancusso and Eric Gouaux
Nature 438, 185–192
(10 November 2005); doi:10.1038/nature04089
| Summary | Full Text (HTML / PDF) |

letter
Gigaxonin-controlled degradation of MAP1B light chain is critical to neuronal survival
Elizabeth Allen, Jianqing Ding, Wei Wang, Suneet Pramanik, Jonathan Chou, Vincent Yau and Yanmin Yang
Nature 438, 224–228
(10 November 2005); doi:10.1038/nature04256
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letter
Fruitless specifies sexually dimorphic neural circuitry in the Drosophila brain
Ken-Ichi Kimura, Manabu Ote, Tatsunori Tazawa and Daisuke Yamamoto
Nature 438, 229–233
(10 November 2005); doi:10.1038/nature04229
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Suppression of Polycomb group proteins by JNK signalling induces transdetermination in Drosophila imaginal discs
Nara Lee, Cédric Maurange, Leonie Ringrose and Renato Paro
Nature 438, 234–237
(10 November 2005); doi:10.1038/nature04120
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A resetting signal between Drosophila pacemakers synchronizes morning and evening activity
Dan Stoleru, Ying Peng, Pipat Nawathean and Michael Rosbash
Nature 438, 238–242
(10 November 2005); doi:10.1038/nature04192
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Principal pathway coupling agonist binding to channel gating in nicotinic receptors
Won Yong Lee and Steven M. Sine
Nature 438, 243–247
(10 November 2005); doi:10.1038/nature04156
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Cis-trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel
Sarah C. R. Lummis, Darren L. Beene, Lori W. Lee, Henry A. Lester, R. William Broadhurst and Dennis A. Dougherty
Nature 438, 248–252
(10 November 2005); doi:10.1038/nature04130
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A quantitative protein interaction network for the ErbB receptors using protein microarrays
Richard B. Jones, Andrew Gordus, Jordan A. Krall and Gavin MacBeath
Nature Advance online publication
(6 November 2005); doi:10.1038/nature04177
| Abstract | Full Text (HTML / PDF) |

news and views
Unleash the messenger
Asis K. Das and Gordon G. Carmichael
Nature Cell Biology 7, 1054–1055
(November 2005); doi:10.1038/ncb1105-1054
| Full Text (HTML/PDF) |

article
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
Laurie E Harrington, Robin D Hatton, Paul R Mangan, Henrietta Turner, Theresa L Murphy, Kenneth M Murphy and Casey T Weaver
Nature Immunology 6, 1123–1132
(November 2005); doi:10.1038/ni1254
| Abstract | Full Text (HTML/PDF) |

article
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Heon Park, Zhaoxia Li, Xuexian O Yang, Seon Hee Chang, Roza Nurieva, Yi-Hong Wang, Ying Wang, Leroy Hood, Zhou Zhu, Qiang Tian and Chen Dong
Nature Immunology 6, 1133–1141
(November 2005); doi:10.1038/ni1261
| Abstract | Full Text (HTML/PDF) |

news and views
TH-17: a giant step from TH1 and TH2
Thomas A Wynn
Nature Immunology 6, 1069–1070
(November 2005); doi:10.1038/ni1105-1069
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review article
Fuel feeds function: energy metabolism and the T-cell response
Casey J. Fox , Peter S. Hammerman and Craig B. Thompson
Nature Reviews Immunology 5, 844–852
(November 2005); doi:10.1038/nri1710
| Summary | Full Text (HTML / PDF) |

article
Dopamine covalently modifies and functionally inactivates parkin
Matthew J LaVoie, Beth L Ostaszewski, Andreas Weihofen, Michael G Schlossmacher and Dennis J Selkoe
Nature Medicine 11, 1214–1221
(November 2005); doi:10.1038/nm1314
| Abstract | Full Text (HTML/PDF) |

news and views
Neurons inflict self-harm
Mark R Cookson
Nature Medicine 11, 1159–1161
(November 2005); doi:10.1038/nm1105-1159
| Full Text (HTML/PDF) |

letter
Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells
Robert S Ohgami, Dean R Campagna, Eric L Greer, Brendan Antiochos, Alice McDonald, Jing Chen, John J Sharp, Yuko Fujiwara, Jane E Barker and Mark D Fleming
Nature Genetics 37, 1264–1269
(November 2005); doi:10.1038/ng1658
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news and views
A ferrireductase fills the gap in the transferrin cycle
Andrew T McKie
Nature Genetics 37, 1159–1160
(November 2005); doi:10.1038/ng1105-1159
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review article
The organization and inheritance of the mitochondrial genome
Xin Jie Chen and Ronald A. Butow
Nature Reviews Genetics 6, 815–825
(November 2005); doi:10.1038/nrg1708
Nature Reviews Genetics AOP published online
| Summary | Full Text (HTML / PDF) |

article
MPS-1 is a K+ channel β-subunit and a serine/threonine kinase
Shi-Qing Cai, Leonardo Hernandez, Yi Wang, Ki Ho Park and Federico Sesti
Nature Neuroscience 8, 1503–1509
(November 2005); doi:10.1038/nn1557
| Abstract | Full Text (HTML/PDF) |

review article
Mitochondrial uncoupling proteins in the CNS: in support of function and survival
Zane B. Andrews, Sabrina Diano and Tamas L. Horvath
Nature Reviews Neuroscience 6, 829–840
(November 2005); doi:10.1038/nrn1767
| Summary | Full Text (HTML / PDF) |

article
Correlative microscopy and electron tomography of GFP through photooxidation
Markus Grabenbauer, Willie J C Geerts, Julia Fernadez-Rodriguez, Andreas Hoenger, Abraham J Koster and Tommy Nilsson
Nature Methods 2, 857–862
(November 2005); doi:10.1038/nmeth806
| Abstract | Full Text (HTML/PDF) |

article
The yeast Pif1p helicase removes telomerase from telomeric DNA
Jean-Baptiste Boulé, Leticia R. Vega and Virginia A. Zakian
Nature 438, 57–61
(03 November 2005); doi:10.1038/nature04091
| Summary | Full Text (HTML / PDF) |

letter
The transcription factor Engrailed-2 guides retinal axons
Isabelle Brunet, Christine Weinl, Michael Piper, Alain Trembleau, Michel Volovitch, William Harris, Alain Prochiantz and Christine Holt
Nature 438, 94–98
(03 November 2005); doi:10.1038/nature04110
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letter
A protein interaction network of the malaria parasite Plasmodium falciparum
Douglas J. LaCount , Marissa Vignali, Rakesh Chettier, Amit Phansalkar, Russell Bell, Jay R. Hesselberth, Lori W. Schoenfeld, Irene Ota, Sudhir Sahasrabudhe, Cornelia Kurschner, Stanley Fields and Robert E. Hughes
Nature 438, 103–107
(03 November 2005); doi:10.1038/nature04104
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letter
A putative stimulatory role for activator turnover in gene expression
J. Russell Lipford, Geoffrey T. Smith, Yong Chi and Raymond J. Deshaies
Nature 438, 113–116
(03 November 2005); doi:10.1038/nature04098
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news and views
Structural biology: Proteins flex to function
Yuanpeng J. Huang and Gaetano T. Montelione
Nature 438, 36–37
(03 November 2005); doi:10.1038/438036a
| Full Text (HTML / PDF) |

letter
Regulation of cholesterol and sphingomyelin metabolism by amyloid-β and presenilin
Marcus O. W. Grimm, Heike S. Grimm, Andreas J. Pätzold, Eva G. Zinser, Riikka Halonen, Marco Duering, Jakob-A. Tschäpe, Bart De Strooper, Ulrike Müller, Jie Shen and Tobias Hartmann
Nature Cell Biology 7, 1118–1123
(November 2005); doi:10.1038/ncb1313
| Abstract | Full Text (HTML / PDF) |

news and views
Alzheimer peptides perturb lipid-regulating enzymes
Mark P. Mattson, Roy G. Cutler and Dong-Gyu Jo
Nature Cell Biology 7, 1045–1047
(November 2005); doi:10.1038/ncb1105-1045
| Full Text (HTML / PDF) |

letter
Drosophila Ric-8 regulates Gαi cortical localization to promote Gαi-dependent planar orientation of the mitotic spindle during asymmetric cell division
Nicolas B. David, Charlotte A. Martin, Marion Segalen, François Rosenfeld, François Schweisguth and Yohanns Bellaïche
Nature Cell Biology 7, 1083–1090
(November 2005); doi:10.1038/ncb1319
| Abstract | Full Text (HTML / PDF) |

letter
Ric-8 controls Drosophila neural progenitor asymmetric division by regulating heterotrimeric G proteins
Hongyan Wang, Kian Hong Ng, Hongliang Qian, David P. Siderovski, William Chia and Fengwei Yu
Nature Cell Biology 7, 1091–1098
(November 2005); doi:10.1038/ncb1317
| Abstract | Full Text (HTML / PDF) |

letter
Drosophila Ric-8 is essential for plasma-membrane localization of heterotrimeric G proteins
Bernhard Hampoelz, Oliver Hoeller, Sarah K. Bowman, Dara Dunican and Juergen A. Knoblich
Nature Cell Biology 7, 1099–1105
(November 2005); doi:10.1038/ncb1318
| Abstract | Full Text (HTML / PDF) |

news and views
Drosophila G-protein signalling: intricate roles for Ric-8?
Fumio Matsuzaki
Nature Cell Biology 7, 1047–1049
(November 2005); doi:10.1038/ncb1105-1047
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review article
Coordinating ERK/MAPK signaling through scaffolds and inhibitors
Walter Kolch
Nature Reviews Molecular Cell Biology 6, 827–837
(November 2005); doi:10.1038/nrm1743
| Abstract | Full Text (HTML / PDF) |

news and views
Hitching RIG to action
Ganes C Sen and Saumendra N Sarkar
Nature Immunology 6, 1074–1076
(November 2005); doi:10.1038/ni1105-1074
| Full Text (HTML / PDF) |

review article
NK cells in HIV infection: Paradigm for protection or targets for ambush
Anthony S. Fauci, Domenico Mavilio and Shyam Kottilil
Nature Reviews Immunology 5, 835–843
(November 2005); doi:10.1038/nri1711
| Abstract | Full Text (HTML / PDF) |

article
CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection
Jeffrey W Tyner, Osamu Uchida, Naohiro Kajiwara, Edy Y Kim, Anand C Patel, Mary P O'Sullivan, Michael J Walter, Reto A Schwendener, Donald N Cook, Theodore M Danoff and Michael J Holtzman
Nature Medicine 11, 1080–1087
(November 2005); doi:10.1038/nm1303
| Abstract | Full Text (HTML / PDF) |

review article
Mitochondrial tumour suppressors: a genetic and biochemical update
Eyal Gottlieb and Ian P. M. Tomlinson
Nature Reviews Cancer 5, 857–866
(November 2005); doi:10.1038/nrc1737
| Abstract | Full Text (HTML / PDF) |

article
Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits
Margarete Mehrabian, Hooman Allayee, Jirina Stockton, Pek Yee Lum, Thomas A Drake, Lawrence W Castellani, Michael Suh, Christopher Armour, Stephen Edwards, John Lamb, Aldons J Lusis and Eric E Schadt
Nature Genetics 37, 1224–1233
(November 2005); doi:10.1038/ng1619
| Abstract | Full Text (HTML / PDF) |

technical report
Second-generation shRNA libraries covering the mouse and human genome
Jose M Silva, Mamie Z Li, Ken Chang, Wei Ge, Michael C Golding, Richard J Rickles, Despina Siolas, Guang Hu, Patrick J Paddison, Michael R Schlabach, Nihar Sheth, Jeff Bradshaw, Julia Burchard, Amit Kulkarni, Guy Cavet, Ravi Sachidanandam, W Richard McCombie, Michele A Cleary, Stephen J Elledge and Gregory J Hannon
Nature Genetics 37, 1281–1288
(November 2005); doi:10.1038/ng1650
| Abstract | Full Text (HTML / PDF) |

technical report
Probing tumor phenotypes using stable and regulated synthetic microRNA precursors
Ross A Dickins, Michael T Hemann, Jack T Zilfou, David R Simpson, Ingrid Ibarra, Gregory J Hannon and Scott W Lowe
Nature Genetics 37, 1289–1295
(November 2005); doi:10.1038/ng1651
| Abstract | Full Text (HTML / PDF) |

news and views
RNAi the natural way
Bryan R Cullen
Nature Genetics 37, 1163–1165
(November 2005); doi:10.1038/ng1105-1163
| Full Text (HTML / PDF) |

article
Cbln1 is essential for synaptic integrity and plasticity in the cerebellum
Hirokazu Hirai, Zhen Pang, Dashi Bao, Taisuke Miyazaki, Leyi Li, Eriko Miura, Jennifer Parris, Yongqi Rong, Masahiko Watanabe, Michisuke Yuzaki and James I Morgan
Nature Neuroscience 8, 1534–1541
(November 2005); doi:10.1038/nn1576
| Abstract | Full Text (HTML / PDF) |

news and views
How neurons keep in touch
Fekrije Selimi and Nathaniel Heintz
Nature Neuroscience 8, 1417–1418
(November 2005); doi:10.1038/nn1105-1417
| Full Text (HTML / PDF) |

review article
Pathways modulating neural KCNQ/M (Kv7) potassium channels
Patrick Delmas and David A. Brown
Nature Reviews Neuroscience 6, 850–862
(November 2005); doi:10.1038/nrn1785
| Abstract | Full Text (HTML / PDF) |

brief communication
One-step analysis of protein complexes in microliters of cell lysate
Oda Stoevesandt, Karsten Köhler, Rainer Fischer, Ian C D Johnston and Roland Brock
Nature Methods 2, 833–835
(November 2005); doi:10.1038/nmeth802
| Abstract | Full Text (HTML / PDF) |

article
Phosphorylation of ephrin-B1 via the interaction with claudin following cell–cell contact formation
Masamitsu Tanaka, Reiko Kamata and Ryuichi Sakai
The EMBO Journal 24, 3700–3711
(2 November 2005); doi:10.1038/sj.emboj.7600831
| Abstract | Full Text (HTML / PDF) |

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