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Research library: browse by date

January 2006

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The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.

Click here for free access to the 'Featured Articles' section, with new articles every week.

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article
Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing
Dolors Ferres-Marco, Irene Gutierrez-Garcia, Diana M. Vallejo, Jorge Bolivar, Francisco J. Gutierrez-Aviño and Maria Dominguez
Nature 439, 430–436
(26 January 2006); doi:10.1038/nature04376
| Summary | Full Text (HTML / PDF) |

letter
The adult Drosophila posterior midgut is maintained by pluripotent stem cells
Benjamin Ohlstein and Allan Spradling
Nature 439, 470–474
(26 January 2006); doi:10.1038/nature04333
| First Paragraph | Full Text (HTML / PDF) |

letter
Evidence that stem cells reside in the adult Drosophila midgut epithelium
Craig A. Micchelli and Norbert Perrimon
Nature 439, 475–479
(26 January 2006); doi:10.1038/nature04371
| First Paragraph | Full Text (HTML / PDF) |

letter
Pregnenolone stabilizes microtubules and promotes zebrafish embryonic cell movement
Hwei-Jan Hsu, Ming-Ren Liang, Chao-Tsen Chen and Bon-chu Chung
Nature 439, 480–483
(26 January 2006); doi:10.1038/nature04436
| First Paragraph | Full Text (HTML / PDF) |

letter
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
Mitsuhiro Watanabe, Sander M. Houten, Chikage Mataki, Marcelo A. Christoffolete, Brian W. Kim, Hiroyuki Sato, Nadia Messaddeq, John W. Harney, Osamu Ezaki, Tatsuhiko Kodama, Kristina Schoonjans, Antonio C. Bianco and Johan Auwerx
Nature 439, 484–489
(26 January 2006); doi:10.1038/nature04330
| First Paragraph | Full Text (HTML / PDF) |

letter
Chromatin organization and cell fate switch respond to positional information in Arabidopsis
Silvia Costa and Peter Shaw
Nature 439, 493–496
(26 January 2006); doi:10.1038/nature04269
| First Paragraph | Full Text (HTML / PDF) |

letter
A phosphatase complex that dephosphorylates γH2AX regulates DNA damage checkpoint recovery
Michael-Christopher Keogh, Jung-Ae Kim, Michael Downey , Jeffrey Fillingham, Dipanjan Chowdhury, Jacob C. Harrison, Megumi Onishi, Nira Datta, Sarah Galicia, Andrew Emili, Judy Lieberman, Xuetong Shen, Stephen Buratowski, James E. Haber, Daniel Durocher, Jack F. Greenblatt and Nevan J. Krogan
Nature 439, 497–501
(26 January 2006); doi:10.1038/nature04384
| First Paragraph | Full Text (HTML / PDF) |

article
Cdk5 phosphorylates and stabilizes p27kip1 contributing to actin organization and cortical neuronal migration
Takeshi Kawauchi, Kaori Chihama, Yo-ichi Nabeshima and Mikio Hoshino
Nature Cell Biology 8, 17–26
(January 2006); doi:10.1038/ncb1338
| Abstract | Full Text (HTML/PDF) |

news and views
Cdk5 checks p27kip1 in neuronal migration
Orly Reiner and Tamar Sapir
Nature Cell Biology 8, 11–13
(January 2006); doi:10.1038/ncb0106-11
| Full Text (HTML/PDF) |

review article
Function and regulation of Rnd proteins
Pierre Chardin
Nature Reviews Molecular Cell Biology 7, 54–62
(January 2006); doi:10.1038/nrm1788
| Summary | Full Text (HTML / PDF) |

article
Impaired assembly of the major histocompatibility complex class I peptide-loading complex in mice deficient in the oxidoreductase ERp57
Natalio Garbi, Satoshi Tanaka, Frank Momburg and Günter J Hämmerling
Nature Immunology 7, 93–102
(January 2006); doi:10.1038/ni1288
| Abstract | Full Text (HTML/PDF) |

article
The aminopeptidase ERAAP shapes the peptide repertoire displayed by major histocompatibility complex class I molecules
Gianna Elena Hammer, Federico Gonzalez, Marine Champsaur, Dragana Cado and Nilabh Shastri
Nature Immunology 7, 103–112
(January 2006); doi:10.1038/ni1286
| Abstract | Full Text (HTML/PDF) |

news and views
The 'chop-and-change' of MHC class I assembly
Tim Elliott
Nature Immunology 7, 7–9
(January 2006); doi:10.1038/ni0106-7
| Full Text (HTML/PDF) |

review article
Signalling pathways and molecular interactions of NOD1 and NOD2
Warren Strober, Peter J. Murray, Atsushi Kitani and Tomohiro Watanabe
Nature Reviews Immunology 6, 9–20
(January 2006); doi:10.1038/nri1747
| Summary | Full Text (HTML / PDF) |

article
TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes
Yoshimi Nakagawa, Hitoshi Shimano, Tomohiro Yoshikawa, Tomohiro Ide, Mariko Tamura, Mika Furusawa, Takashi Yamamoto, Noriyuki Inoue, Takashi Matsuzaka, Akimitsu Takahashi, Alyssa H Hasty, Hiroaki Suzuki, Hirohito Sone, Hideo Toyoshima, Naoya Yahagi and Nobuhiro Yamada
Nature Medicine 12, 107–113
(January 2006); doi:10.1038/nm1334
| Abstract | Full Text (HTML/PDF) |

review article
KLF4, p21 and context-dependent opposing forces in cancer
Benjamin D. Rowland and Daniel S. Peeper
Nature Reviews Cancer 6, 11–23
(January 2006); doi:10.1038/nrc1780
| Summary | Full Text (HTML / PDF) |

article
Calcium-dependent interaction of Lis1 with IQGAP1 and Cdc42 promotes neuronal motility
Stanislav S Kholmanskikh, Hajira B Koeller, Anthony Wynshaw-Boris, Timothy Gomez, Paul C Letourneau and M Elizabeth Ross
Nature Neuroscience 9, 50–57
(January 2006); doi:10.1038/nn1619
| Abstract | Full Text (HTML/PDF) |

brief communication
Production of a recombinant bacterial lipoprotein in higher plant chloroplasts
Karin Glenz, Bernadette Bouchon, Thomas Stehle, Reinhard Wallich, Markus M Simon and Heribert Warzecha
Nature Biotechnology 24, 76–77
(January 2006); doi:10.1038/nbt1170
| First Paragraph | Full Text (HTML/PDF) |

news and views
Kinase cogs go forward and reverse in the Wnt signaling machine
Trevor Dale
Nature Structural and Molecular Biology 13, 9–11
(January 2006); doi:10.1038/nsmb0106-9
| Full Text (HTML/PDF) |

article
A brain-specific microRNA regulates dendritic spine development
Gerhard M. Schratt , Fabian Tuebing, Elizabeth A. Nigh , Christina G. Kane , Mary E. Sabatini, Michael Kiebler and Michael E. Greenberg
Nature 439, 283–289
(19 January 2006); doi:10.1038/nature04367
| Summary | Full Text (HTML / PDF) |

article
The RNA-binding protein FCA is an abscisic acid receptor
Fawzi A. Razem, Ashraf El-Kereamy, Suzanne R. Abrams and Robert D. Hill
Nature 439, 290–294
(19 January 2006); doi:10.1038/nature04373
| Summary | Full Text (HTML / PDF) |

letter
Constant darkness is a circadian metabolic signal in mammals
Jianfa Zhang, Krista Kaasik, Michael R. Blackburn and Cheng Chi Lee
Nature 439, 340–343
(19 January 2006); doi:10.1038/nature04368
| First Paragraph | Full Text (HTML / PDF) |

letter
Oscillations of cyclic AMP in hormone-stimulated insulin-secreting β-cells
Oleg Dyachok, Yegor Isakov, Jenny Sågetorp and Anders Tengholm
Nature 439, 349–352
(19 January 2006); doi:10.1038/nature04410
| First Paragraph | Full Text (HTML / PDF) |

letter
Oncogenic pathway signatures in human cancers as a guide to targeted therapies
Andrea H. Bild, Guang Yao, Jeffrey T. Chang, Quanli Wang, Anil Potti, Dawn Chasse, Mary-Beth Joshi, David Harpole, Johnathan M. Lancaster, Andrew Berchuck, John A. Olson Jr, Jeffrey R. Marks, Holly K. Dressman, Mike West and Joseph R. Nevins
Nature 439, 353–357
(February 2006); doi:10.1038/nature04296
| First Paragraph | Full Text (HTML / PDF) |

letter
BRAF mutation predicts sensitivity to MEK inhibition
David B. Solit, Levi A. Garraway, Christine A. Pratilas, Ayana Sawai, Gad Getz, Andrea Basso, Qing Ye, Jose M. Lobo, Yuhong She, Iman Osman, Todd R. Golub, Judith Sebolt-Leopold, William R. Sellers and Neal Rosen
Nature 439, 358–362
(February 2006); doi:10.1038/nature04304
| First Paragraph | Full Text (HTML / PDF) |

letter
Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells
Oleg O. Glebov, Nicholas A. Bright and Benjamin J. Nichols
Nature Cell Biology 8, 46–54
(January 2006); doi:10.1038/ncb1342
| First Paragraph | Full Text (HTML/PDF) |

letter
In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis
Shine Tu, Gavin P. McStay, Louis-Martin Boucher, Tak Mak, Helen M. Beere and Douglas R. Green
Nature Cell Biology 8, 72–77
(January 2006); doi:10.1038/ncb1340
| First Paragraph | Full Text (HTML/PDF) |

review article
Developmental cell biology: Making digit patterns in the vertebrate limb
Cheryll Tickle
Nature Reviews Molecular Cell Biology 7, 45–53
(January 2006); doi:10.1038/nrm1830
| Summary | Full Text (HTML / PDF) |

article
Src-like adaptor protein regulates TCR expression on thymocytes by linking the ubiquitin ligase c-Cbl to the TCR complex
Margaret D Myers, Tomasz Sosinowski, Leonard L Dragone, Carmen White, Hamid Band, Hua Gu and Arthur Weiss
Nature Immunology 7, 57–66
(January 2006); doi:10.1038/ni1291
| Abstract | Full Text (HTML/PDF) |

review article
SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond
Gary A. Koretzky, Farhad Abtahian and Michael A. Silverman
Nature Reviews Immunology 6, 67–78
(January 2006); doi:10.1038/nri1750
| Summary | Full Text (HTML / PDF) |

article
A role for the scaffolding adapter GAB2 in breast cancer
Mohamed Bentires-Alj, Susana G Gil, Richard Chan, Zhigang C Wang, Yongping Wang, Naoko Imanaka, Lyndsay N Harris, Andrea Richardson, Benjamin G Neel and Haihua Gu
Nature Medicine 12, 114–121
(January 2006); doi:10.1038/nm1341
| Abstract | Full Text (HTML/PDF) |

letter
Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer
George V Thomas, Chris Tran, Ingo K Mellinghoff, Derek S Welsbie, Emily Chan, Barbara Fueger, Johannes Czernin and Charles L Sawyers
Nature Medicine 12, 122–127
(January 2006); doi:10.1038/nm1337
| First Paragraph | Full Text (HTML/PDF) |

article
A positive signal from the fertilization of the egg cell sets off endosperm proliferation in angiosperm embryogenesis
Moritz K Nowack, Paul E Grini, Marc J Jakoby, Marcel Lafos, Csaba Koncz and Arp Schnittger
Nature Genetics 38, 63–67
(January 2006); doi:10.1038/ng1694
| Abstract | Full Text (HTML/PDF) |

review article
Microarray data analysis: from disarray to consolidation and consensus
David B. Allison , Xiangqin Cui, Grier P. Page and Mahyar Sabripour
Nature Reviews Genetics 7, 55–65
(January 2006); doi:10.1038/nrg1749
| Summary | Full Text (HTML / PDF) |

article
DWnt4 regulates the dorsoventral specificity of retinal projections in the Drosophila melanogaster visual system
Makoto Sato, Daiki Umetsu, Satoshi Murakami, Tetsuo Yasugi and Tetsuya Tabata
Nature Neuroscience 9, 67–75
(January 2006); doi:10.1038/nn1604
| Abstract | Full Text (HTML/PDF) |

article
Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis
Makoto Urushitani, Attila Sik, Takashi Sakurai, Nobuyuki Nukina, Ryosuke Takahashi and Jean-Pierre Julien
Nature Neuroscience 9, 108–118
(January 2006); doi:10.1038/nn1603
| Abstract | Full Text (HTML/PDF) |

news and views
Damaging secretions: chromogranins team up with mutant SOD1
Michael Sendtner
Nature Neuroscience 9, 12–14
(January 2006); doi:10.1038/nn0106-12
| Full Text (HTML/PDF) |

protocol
Strategies for protein coexpression in Escherichia coli
Niraj H Tolia and Leemor Joshua-Tor
Nature Methods 3, 55–64
(January 2006); doi:10.1038/nmeth0106-55
| Full Text (HTML/PDF) |

classic protocol
Transfection of mammalian cells by electroporation
Nature Methods 3, 67–68
(January 2006); doi:10.1038/nmeth0106-67
| Full Text (HTML/PDF) |

letter
A genetic strategy to treat sickle cell anemia by coregulating globin transgene expression and RNA interference
Selda Samakoglu, Leszek Lisowski, Tulin Budak-Alpdogan, Yelena Usachenko, Santina Acuto, Rosalba Di Marzo, Aurelio Maggio, Ping Zhu, John F. Tisdale, Isabelle Rivière and Michel Sadelain
Nature Biotechnology 24, 89–94
(January 2006); doi:10.1038/nbt1176
| First Paragraph | Full Text (HTML/PDF) |

article
Structure of an RNA polymerase II-RNA inhibitor complex elucidates transcription regulation by noncoding RNAs
Hubert Kettenberger, Alexander Eisenführ, Florian Brueckner, Mirko Theis, Michael Famulok and Patrick Cramer
Nature Structural and Molecular Biology 13, 44–48
(January 2006); doi:10.1038/nsmb1032
| Abstract | Full Text (HTML/PDF) |

letter
Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6
Hans Häcker, Vanessa Redecke, Blagoy Blagoev, Irina Kratchmarova, Li-Chung Hsu, Gang G. Wang, Mark P. Kamps, Eyal Raz, Hermann Wagner, Georg Häcker, Matthias Mann and Michael Karin
Nature 439, 204–207
(12 January 2006); doi:10.1038/nature04369
| First Paragraph | Full Text (HTML / PDF) |

letter
Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response
Gagik Oganesyan, Supriya K. Saha, Beichu Guo, Jeannie Q. He, Arash Shahangian, Brian Zarnegar, Andrea Perry and Genhong Cheng
Nature 439, 208–211
(12 January 2006); doi:10.1038/nature04374
| First Paragraph | Full Text (HTML / PDF) |

letter
Generation of nuclear transfer-derived pluripotent ES cells from cloned Cdx2-deficient blastocysts
Alexander Meissner and Rudolf Jaenisch
Nature 439, 212–215
(12 January 2006); doi:10.1038/nature04257
| First Paragraph | Full Text (HTML / PDF) |

letter
Embryonic and extraembryonic stem cell lines derived from single mouse blastomeres
Young Chung, Irina Klimanskaya, Sandy Becker, Joel Marh, Shi-Jiang Lu, Julie Johnson, Lorraine Meisner and Robert Lanza
Nature 439, 216–219
(12 January 2006); doi:10.1038/nature04277
| First Paragraph | Full Text (HTML / PDF) |

news and views
Medicine: Politic stem cells
Irving L. Weissman
Nature 439, 145–147
(12 January 2006); doi:10.1038/439145a
| Full Text (HTML / PDF) |

letter
Planar cell polarity signalling couples cell division and morphogenesis during neurulation
Brian Ciruna, Andreas Jenny, Diana Lee, Marek Mlodzik and Alexander F. Schier
Nature 439, 220–224
(12 January 2006); doi:10.1038/nature04375
| First Paragraph | Full Text (HTML / PDF) |

letter
Structure of the Sec13/31 COPII coat cage
Scott M. Stagg , Cemal Gürkan, Douglas M. Fowler, Paul LaPointe, Ted R. Foss, Clinton S. Potter, Bridget Carragher and William E. Balch
Nature 439, 234–238
(12 January 2006); doi:10.1038/nature04339
| First Paragraph | Full Text (HTML / PDF) |

article
The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis
Fisun Hamaratoglu, Maria Willecke, Madhuri Kango-Singh, Riitta Nolo, Eric Hyun, Chunyao Tao, Hamed Jafar-Nejad and Georg Halder
Nature Cell Biology 8, 27–36
(January 2006); doi:10.1038/ncb1339
| Abstract | Full Text (HTML/PDF) |

letter
The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores
Benjamin A. Pinsky, Charles Kung, Kevan M. Shokat and Sue Biggins
Nature Cell Biology 8, 78–83
(January 2006); doi:10.1038/ncb1341
| First Paragraph | Full Text (HTML/PDF) |

news and views
A SAGA of proteasomal ATPases
Sowmya Swaminathan
Nature Cell Biology 8, 13
(January 2006); doi:10.1038/ncb0106-13
| Full Text (HTML/PDF) |

review article
ILK, PINCH and parvin: the tIPP of integrin signalling
Kyle R. Legate, Eloi Montañez, Oliver Kudlacek and Reinhard Fässler
Nature Reviews Molecular Cell Biology 7, 20
| Summary | Full Text (HTML / PDF) |

article
Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity
Jennifer E Fenner, Robyn Starr, Ann L Cornish, Jian-Guo Zhang, Donald Metcalf, Robert D Schreiber, Kathleen Sheehan, Douglas J Hilton, Warren S Alexander and Paul J Hertzog
Nature Immunology 7, 33–39
(January 2006); doi:10.1038/ni1287
| Abstract | Full Text (HTML/PDF) |

review article
Dectin-1: a signalling non-TLR pattern-recognition receptor
Gordon D. Brown
Nature Reviews Immunology 6, 33–43
(January 2006); doi:10.1038/nri1745
| Summary | Full Text (HTML / PDF) |

article
IL-13 signaling through the IL-13α2 receptor is involved in induction of TGF-β1 production and fibrosis
Stefan Fichtner-Feigl, Warren Strober, Koji Kawakami, Raj K Puri and Atsushi Kitani
Nature Medicine 12, 99–106
(January 2006); doi:10.1038/nm1332
| Abstract | Full Text (HTML/PDF) |

technical report
Lipid microarrays identify key mediators of autoimmune brain inflammation
Jennifer L Kanter, Sirisha Narayana, Peggy P Ho, Ingrid Catz, Kenneth G Warren, Raymond A Sobel, Lawrence Steinman and William H Robinson
Nature Medicine 12, 138–143
(January 2006); doi:10.1038/nm1344
| Abstract | Full Text (HTML/PDF) |

review article
A PANorama of PAX genes in cancer and development
Ewan J. D. Robson, Shu-Jie He and Michael R. Eccles
Nature Reviews Cancer 6, 52–62
(January 2006); doi:10.1038/nrc1778
| Summary | Full Text (HTML / PDF) |

article
Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1
Frank Rosenbauer, Bronwyn M Owens, Li Yu, Joseph R Tumang, Ulrich Steidl, Jeffery L Kutok, Linda K Clayton, Katharina Wagner, Marina Scheller, Hiromi Iwasaki, Chunhui Liu, Björn Hackanson, Koichi Akashi, Achim Leutz, Thomas L Rothstein, Christoph Plass and Daniel G Tenen
Nature Genetics 38, 27–37
(January 2006); doi:10.1038/ng1679
| Abstract | Full Text (HTML/PDF) |

review article
Filtering transcriptional noise during development: concepts and mechanisms
Alfonso Martinez Arias and Penelope Hayward
Nature Reviews Genetics 7, 34–44
(January 2006); doi:10.1038/nrg1750
| Summary | Full Text (HTML / PDF) |

article
CaM kinase II phosphorylation of slo Thr107 regulates activity and ethanol responses of BK channels
Jianxi Liu, Maria Asuncion-Chin, Pengchong Liu and Alejandro M Dopico
Nature Neuroscience 9, 41–49
(January 2006); doi:10.1038/nn1602
| Abstract | Full Text (HTML/PDF) |

review article
Astrocyte-endothelial interactions at the blood-brain barrier
N. Joan Abbott, Lars Rönnbäck and Elisabeth Hansson
Nature Reviews Neuroscience 7, 41–53
(January 2006); doi:10.1038/nrn1824
| Summary | Full Text (HTML / PDF) |

article
A single-molecule method for the quantitation of microRNA gene expression
Lori A Neely, Sonal Patel, Joanne Garver, Michael Gallo, Maria Hackett, Stephen McLaughlin, Mark Nadel, John Harris, Steve Gullans and Jenny Rooke
Nature Methods 3, 41–46
(January 2006); doi:10.1038/nmeth825
| Abstract | Full Text (HTML/PDF) |

brief communication
In situ detection of miRNAs in animal embryos using LNA-modified oligonucleotide probes
Wigard P Kloosterman, Erno Wienholds, Ewart de Bruijn, Sakari Kauppinen and Ronald H A Plasterk
Nature Methods 3, 27–29
(January 2006); doi:10.1038/nmeth843
| First Paragraph | Full Text (HTML/PDF) |

news and views
microRNA detection comes of age
Scott M Hammond
Nature Methods 3, 12–13
(January 2006); doi:10.1038/nmeth0106-12
| Full Text (HTML/PDF) |

review article
COX isoforms in the cardiovascular system: understanding the activities of non-steroidal anti-inflammatory drugs
Jane A. Mitchell and Timothy D. Warner
Nature Reviews Drug Discovery 5, 75–86
(January 2006); doi:10.1038/nrd1929
| Summary | Full Text (HTML / PDF) |

article
Wnt-Ryk signalling mediates medial-lateral retinotectal topographic mapping
Adam M. Schmitt, Jun Shi, Alex M. Wolf, Chin-Chun Lu, Leslie A. King and Yimin Zou
Nature 439, 31–37
(05 January 2006); doi:10.1038/nature04334
| Summary | Full Text (HTML / PDF) |

letter
Generation of a functional mammary gland from a single stem cell
Mark Shackleton, François Vaillant, Kaylene J. Simpson, John Stingl, Gordon K. Smyth, Marie-Liesse Asselin-Labat, Li Wu, Geoffrey J. Lindeman and Jane E. Visvader
Nature 439, 84–88
(05 January 2006); doi:10.1038/nature04372
| First Paragraph | Full Text (HTML / PDF) |

letter
An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection
Deborah Palliser, Dipanjan Chowdhury, Qing-Yin Wang, Sandra J. Lee, Roderick T. Bronson, David M. Knipe and Judy Lieberman
Nature 439, 89–94
(05 January 2006); doi:10.1038/nature04263
| First Paragraph | Full Text (HTML / PDF) |

letter
Potentiation of neuroblastoma metastasis by loss of caspase-8
Dwayne G. Stupack, Tal Teitz, Matthew D. Potter, David Mikolon, Peter J. Houghton, Vincent J. Kidd, Jill M. Lahti and David A. Cheresh
Nature 439, 95–99
(05 January 2006); doi:10.1038/nature04323
| First Paragraph | Full Text (HTML / PDF) |

letter
RNA translocation and unwinding mechanism of HCV NS3 helicase and its coordination by ATP
Sophie Dumont, Wei Cheng, Victor Serebrov, Rudolf K. Beran, Ignacio Tinoco Jr, Anna Marie Pyle and Carlos Bustamante
Nature 439, 105–108
(05 January 2006); doi:10.1038/nature04331
| First Paragraph | Full Text (HTML / PDF) |

letter
Dishevelled mediates ephrinB1 signalling in the eye field through the planar cell polarity pathway
Hyun-Shik Lee, Yong-Sik Bong, Kathryn B. Moore, Kathleen Soria, Sally A. Moody and Ira O. Daar
Nature Cell Biology 8, 55–63
(January 2006); doi:10.1038/ncb1344
| First Paragraph | Full Text (HTML/PDF) |

news and views
Ephrins make eyes with planar cell polarity
Alexei Poliakov and David G. Wilkinson
Nature Cell Biology 8, 7–8
(January 2006); doi:10.1038/ncb0106-7
| Full Text (HTML/PDF) |

review article
Life of a clathrin coat: insights from clathrin and AP structures
Melissa A. Edeling, Corinne Smith and David Owen
Nature Reviews Molecular Cell Biology 7, 32–44
(January 2006); doi:10.1038/nrm1786
| Summary | Full Text (HTML / PDF) |

review article
Lymphocyte calcium signaling from membrane to nucleus
Elena M Gallo, Kirsten Canté-Barrett and Gerald R Crabtree
Nature Immunology 7, 25–32
(January 2006); doi:10.1038/ni1295
| Abstract | Full Text (HTML/PDF) |

article
Mechanistic basis of pre-T cell receptor–mediated autonomous signaling critical for thymocyte development
Sho Yamasaki, Eri Ishikawa, Machie Sakuma, Koji Ogata, Kumiko Sakata-Sogawa, Michio Hiroshima, David L Wiest, Makio Tokunaga and Takashi Saito
Nature Immunology 7, 67–75
(January 2006); doi:10.1038/ni1290
| Abstract | Full Text (HTML/PDF) |

review article
Immune regulation by SLAM family receptors and SAP-related adaptors
André Veillette
Nature Reviews Immunology 6, 56–66
(January 2006); doi:10.1038/nri1761
| Summary | Full Text (HTML / PDF) |

article
Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation
Jennifer J Trowbridge, Anargyros Xenocostas, Randall T Moon and Mickie Bhatia
Nature Medicine 12, 89–98
(January 2006); doi:10.1038/nm1339
| Abstract | Full Text (HTML/PDF) |

brief communication
APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy
Anne Rovelet-Lecrux, Didier Hannequin, Gregory Raux, Nathalie Le Meur, Annie Laquerrière, Anne Vital, Cécile Dumanchin, Sébastien Feuillette, Alexis Brice, Martine Vercelletto, Frédéric Dubas, Thierry Frebourg and Dominique Campion
Nature Genetics 38, 24–26
(January 2006); doi:10.1038/ng1718
| First Paragraph | Full Text (HTML/PDF) |

review article
The epigenetic progenitor origin of human cancer
Andrew P. Feinberg, Rolf Ohlsson and Steven Henikoff
Nature Reviews Genetics 7, 21–33
(January 2006); doi:10.1038/nrg1748
| Summary | Full Text (HTML / PDF) |

article
ORL1 receptor-mediated internalization of N-type calcium channels
Christophe Altier, Houman Khosravani, Rhian M Evans, Shahid Hameed, Jean B Peloquin, Brian A Vartian, Lina Chen, Aaron M Beedle, Stephen S G Ferguson, Alexandre Mezghrani, Stefan J Dubel, Emmanuel Bourinet, John E McRory and Gerald W Zamponi
Nature Neuroscience 9, 31–40
(January 2006); doi:10.1038/nn1605
| Abstract | Full Text (HTML/PDF) |

news and views
Internalizing channels: a mechanism to control pain?
Diane Lipscombe and Jesica Raingo
Nature Neuroscience 9, 8–10
(January 2006); doi:10.1038/nn0106-8
| Full Text (HTML/PDF) |

article
The nitrodibenzofuran chromophore: a new caging group for ultra-efficient photolysis in living cells
Atsuya Momotake, Nicolas Lindegger, Ernst Niggli, Robert J Barsotti and Graham C R Ellis-Davies
Nature Methods 3, 35–40
(January 2006); doi:10.1038/nmeth821
| Abstract | Full Text (HTML/PDF) |

news and views
Crafting new cages
Wen-Hong Li
Nature Methods 3, 13–15
(January 2006); doi:10.1038/nmeth0106-13
| Full Text (HTML/PDF) |

article
The human SWI/SNF subunit Brm is a regulator of alternative splicing
Eric Batsché, Moshe Yaniv and Christian Muchardt
Nature Structural and Molecular Biology 13, 22–29
(January 2006); doi:10.1038/nsmb1030
| Abstract | Full Text (HTML/PDF) |

news and views
Chromatin, transcript elongation and alternative splicing
Alberto R Kornblihtt
Nature Structural and Molecular Biology 13, 5–7
(January 2006); doi:10.1038/nsmb0106-5
| Full Text (HTML/PDF) |

brief communication
Conservation of gene expression signatures between zebrafish and human liver tumors and tumor progression
Siew Hong Lam, Yi Lian Wu, Vinsensius B Vega, Lance D Miller, Jan Spitsbergen, Yan Tong, Huiqing Zhan, Kunde R Govindarajan, Serene Lee, Sinnakarupan Mathavan, Karuturi R Krishna Murthy, Donald R Buhler, Edison T Liu and Zhiyuan Gong
Nature Biotechnology 24, 73–75
(January 2006); doi:10.1038/nbt1169
| First Paragraph | Full Text (HTML/PDF) |

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