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Research library: browse by date

June 2006

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The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.

Click here for free access to the 'Featured Articles' section, with new articles every week.

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article
Ovulated oocytes in adult mice derive from non-circulating germ cells
Kevin Eggan, Sara Jurga, Roger Gosden, Irene M. Min and Amy J. Wagers
Nature 441, 1109–1114
(29 June 2006); doi:10.1038/nature04929
| Summary | Full Text (HTML / PDF) |

letter
Activity-dependent dynamics and sequestration of proteasomes in dendritic spines
Baris Bingol and Erin M. Schuman
Nature 441, 1144–1148
(29 June 2006); doi:10.1038/nature04769
| First Paragraph | Full Text (HTML / PDF) |

letter
Nodulation independent of rhizobia induced by a calcium-activated kinase lacking autoinhibition
Cynthia Gleason, Shubho Chaudhuri, Tianbao Yang, Alfonso Muñoz, B. W. Poovaiah and Giles E. D. Oldroyd
Nature 441, 1149–1152
(29 June 2006); doi:10.1038/nature04812
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letter
Deregulation of a Ca2+/calmodulin-dependent kinase leads to spontaneous nodule development
Leïla Tirichine, Haruko Imaizumi-Anraku, Satoko Yoshida, Yasuhiro Murakami, Lene H. Madsen, Hiroki Miwa, Tomomi Nakagawa, Niels Sandal, Anita S. Albrektsen, Masayoshi Kawaguchi, Allan Downie, Shusei Sato, Satoshi Tabata, Hiroshi Kouchi, Martin Parniske, Shinji Kawasaki and Jens Stougaard
Nature 441, 1153–1156
(29 June 2006); doi:10.1038/nature04862
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letter
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
Jeehye Park , Sung Bae Lee , Sungkyu Lee, Yongsung Kim, Saera Song, Sunhong Kim, Eunkyung Bae, Jaeseob Kim, Minho Shong, Jin-Man Kim and Jongkyeong Chung
Nature 441, 1157–1161
(29 June 2006); doi:10.1038/nature04788
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letter
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
Ira E. Clark, Mark W. Dodson, Changan Jiang, Joseph H. Cao, Jun R. Huh, Jae Hong Seol, Soon Ji Yoo, Bruce A. Hay and Ming Guo
Nature 441, 1162–1166
(29 June 2006); doi:10.1038/nature04779
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news and views
Neurodegenerative disease: Pink, parkin and the brain
Leo Pallanck and J. Timothy Greenamyre
Nature 441, 1058
(29 June 2006); doi:10.1038/4411058a
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letter
Structural basis for gene regulation by a thiamine pyrophosphate-sensing riboswitch
Alexander Serganov, Anna Polonskaia, Anh Tuân Phan, Ronald R. Breaker and Dinshaw J. Patel
Nature 441, 1167–1171
(29 June 2006); doi:10.1038/nature04740
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letter
Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C
Michelle J. Hayes, Yuu Kimata, Samantha L. Wattam, Catherine Lindon, Guojie Mao, Hiroyuki Yamano & Andrew M. Fry
Nature Cell Biology 8, 607 - 614
(June 2006); doi:10.1038/ncb1410
| First Paragraph | Full Text (HTML / PDF) |

review article
New insights into cystic fibrosis: molecular switches that regulate CFTR
William B. Guggino and Bruce A. Stanton
Nature Reviews Molecular Cell Biology 7, 426–436
(June 2006); doi:10.1038/nrm1949
| Summary | Full Text (HTML / PDF) |

article
ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses
Stamatia Papoutsopoulou, Antony Symons, Tharsana Tharmalingham, Monica P Belich, Frank Kaiser, Dimitris Kioussis, Anne O'Garra, Victor Tybulewicz & Steven C Ley
Nature Immunology 7, 606 - 615
(June 2006); doi:10.1038/ni1334
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review article
CEACAM1: contact-dependent control of immunity
Scott D. Gray-Owen and Richard S. Blumberg
Nature Reviews Immunology 6, 433–446
(June 2006); doi:10.1038/nri1864
| Summary | Full Text (HTML / PDF) |

article
Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance
Mihai G Netea, Leo A B Joosten, Eli Lewis, Dalan R Jensen, Peter J Voshol, Bart Jan Kullberg, Cees J Tack, Han van Krieken, Soo-Hyun Kim, Anton F Stalenhoef, Fons A van de Loo, Ineke Verschueren, Leslie Pulawa, Shizuo Akira, Robert H Eckel, Charles A Dinarello, Wim van den Berg & Jos W M van der Meer
Nature Medicine 12, 650 - 656
(June 2006); doi:10.1038/nm1415
| Summary | Full Text (HTML / PDF) |

technical report
Live imaging of lymphatic development in the zebrafish
Karina Yaniv, Sumio Isogai, Daniel Castranova, Louis Dye, Jiro Hitomi & Brant M Weinstein
Nature Medicine 12, 711 - 716
(June 2006); doi:10.1038/nm1427
| Summary | Full Text (HTML / PDF) |

review article
Brain tumour stem cells
Angelo L. Vescovi, Rossella Galli and Brent A. Reynolds
Nature Reviews Cancer 6, 425–436
(June 2006); doi:10.1038/nrc1889
| Summary | Full Text (HTML / PDF) |

article
Midline radial glia translocation and corpus callosum formation require FGF signaling
Karen Müller Smith, Yasushi Ohkubo, Maria Elisabetta Maragnoli, Mladen-Roko Ras caronin, Michael L Schwartz, Nenad S caronestan & Flora M Vaccarino
Nature Neuroscience 9, 787 - 797
(June 2006); doi:10.1038/nn1705
| Summary | Full Text (HTML / PDF) |

review article
Purinergic signalling in neuron-glia interactions
R. Douglas Fields and Geoffrey Burnstock
Nature Reviews Neuroscience 7, 423–436
(June 2006); doi:10.1038/nrn1928
| Summary | Full Text (HTML / PDF) |

review article
Therapeutic potential of Toll-like receptor 9 activation
Arthur M. Krieg
Nature Reviews Drug Discovery 5, 471–484
(June 2006); doi:10.1038/nrd2059
| Summary | Full Text (HTML / PDF) |

letter
Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells
Patricia M. White, Angelika Doetzlhofer, Yun Shain Lee, Andrew K. Groves and Neil Segil
Nature 441, 984–987
(22 June 2006); doi:10.1038/nature04849
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letter
Clonal analysis reveals a common progenitor for thymic cortical and medullary epithelium
Simona W. Rossi, William E. Jenkinson, Graham Anderson and Eric J. Jenkinson
Nature 441, 988–991
(22 June 2006); doi:10.1038/nature04813
| First Paragraph | Full Text (HTML / PDF) |

letter
Nanog promotes transfer of pluripotency after cell fusion
José Silva, Ian Chambers, Steven Pollard and Austin Smith
Nature 441, 997–1001
(22 June 2006); doi:10.1038/nature04914
| First Paragraph | Full Text (HTML / PDF) |

letter
Golgi maturation visualized in living yeast
Eugene Losev, Catherine A. Reinke, Jennifer Jellen, Daniel E. Strongin, Brooke J. Bevis and Benjamin S. Glick
Nature 441, 1002–1006
(22 June 2006); doi:10.1038/nature04717
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letter
Live imaging of yeast Golgi cisternal maturation
Kumi Matsuura-Tokita, Masaki Takeuchi, Akira Ichihara, Kenta Mikuriya and Akihiko Nakano
Nature 441, 1007–1010
(22 June 2006); doi:10.1038/nature04737
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letter
Smad4 signalling in T cells is required for suppression of gastrointestinal cancer
Byung-Gyu Kim, Cuiling Li, Wenhui Qiao, Mizuko Mamura, Barbara Kasperczak, Miriam Anver, Lawrence Wolfraim, Suntaek Hong, Elizabeth Mushinski, Michael Potter, Seong-Jin Kim, Xin-Yuan Fu, Chuxia Deng and John J. Letterio
Nature 441, 1015–1019
(22 June 2006); doi:10.1038/nature04846
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letter
Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis
Noriko Takegahara, Hyota Takamatsu, Toshihiko Toyofuku, Tohru Tsujimura, Tatsusada Okuno, Kazunori Yukawa, Masayuki Mizui, Midori Yamamoto, Durbaka V.R. Prasad, Kazuhiro Suzuki, Masaru Ishii, Kenta Terai, Masayuki Moriya, Yuji Nakatsuji, Saburo Sakoda, Shintaro Sato, Shizuo Akira, Kiyoshi Takeda, Masanori Inui, Toshiyuki Takai, Masahito Ikawa, Masaru Okabe, Atsushi Kumanogoh & Hitoshi Kikutani
Nature Cell Biology 8, 615 - 622
(June 2006); doi:10.1038/ncb1416
| Summary | Full Text (HTML / PDF) |

news and views
Semaphorin pathways orchestrate osteogenesis
Luca Tamagnone & Silvia Giordano
Nature Cell Biology 8, 545 - 547
(June 2006); doi:10.1038/ncb0606-545
| Summary | Full Text (HTML / PDF) |

news and views
TGF-ß, a 'double agent' in the immune pathology war
Daniel J Cua & Robert A Kastelein
Nature Immunology 7, 557 - 559
(June 2006); doi:10.1038/ni0606-557
| Summary | Full Text (HTML / PDF) |

letter
Generation of C5a in the absence of C3: a new complement activation pathway
Markus Huber-Lang, J Vidya Sarma, Firas S Zetoune, Daniel Rittirsch, Thomas A Neff, Stephanie R McGuire, John D Lambris, Roscoe L Warner, Michael A Flierl, Laszlo M Hoesel, Florian Gebhard, John G Younger, Scott M Drouin, Rick A Wetsel & Peter A Ward
Nature Medicine 12, 682 - 687
(June 2006); doi:10.1038/nm1419
| Summary | Full Text (HTML / PDF) |

letter
Synaptic scaffolding protein Homer1a protects against chronic inflammatory pain
Anke Tappe, Matthias Klugmann, Ceng Luo, David Hirlinger, Nitin Agarwal, Justus Benrath, Markus U Ehrengruber, Matthew J During & Rohini Kuner
Nature Medicine 12, 677 - 681
(June 2006); doi:10.1038/nm1406
| Summary | Full Text (HTML / PDF) |

review article
p21-activated kinases in cancer
Rakesh Kumar, Anupama E. Gururaj and Christopher J. Barnes
Nature Reviews Cancer 6, 459–471
(June 2006); doi:10.1038/nrc1892
| Summary | Full Text (HTML / PDF) |

article
Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism
Valérie Senée, Claude Chelala, Sabine Duchatelet, Daorong Feng, Hervé Blanc, Jack-Christophe Cossec, Céline Charon, Marc Nicolino, Pascal Boileau, Douglas R Cavener, Pierre Bougnères, Doris Taha & Cécile Julier
Nature Genetics 38, 682 - 687
(June 2006); doi:10.1038/ng1802
| Summary | Full Text (HTML / PDF) |

article
Synapse-specific plasticity and compartmentalized signaling in cerebellar stellate cells
Markus Huber-Lang, J Vidya Sarma, Firas S Zetoune, Daniel Rittirsch, Thomas A Neff, Stephanie R McGuire, John D Lambris, Roscoe L Warner, Michael A Flierl, Laszlo M Hoesel, Florian Gebhard, John G Younger, Scott M Drouin, Rick A Wetsel & Peter A Ward
Nature Neuroscience 9, 798 - 806
(June 2006); doi:10.1038/nn1698
| Summary | Full Text (HTML / PDF) |

news and views
Biochemical confinements without walls in aspiny neurons
Pablo E Castillo & Kamran Khodakhah
Nature Neuroscience 9, 719 - 720
(June 2006); doi:10.1038/nn0606-719
| Summary | Full Text (HTML / PDF) |

letter
A microengraving method for rapid selection of single cells producing antigen-specific antibodies
J Christopher Love, Jehnna L Ronan, Gijsbert M Grotenbreg, Annemarthe G van der Veen & Hidde L Ploegh
Nature Biotechnology 24, 703 - 707
(June 2006); doi:10.1038/nbt1210
| Summary | Full Text (HTML / PDF) |

article
Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise
John R. S. Newman, Sina Ghaemmaghami , Jan Ihmels, David K. Breslow, Matthew Noble, Joseph L. DeRisi and Jonathan S. Weissman
Nature 441, 840–846
(15 June 2006); doi:10.1038/nature04785
| Summary | Full Text (HTML / PDF) |

article
Distribution and three-dimensional structure of AIDS virus envelope spikes
Ping Zhu, Jun Liu, Julian Bess Jr, Elena Chertova, Jeffrey D. Lifson, Henry Grisé, Gilad A. Ofek, Kenneth A. Taylor and Kenneth H. Roux
Nature 441, 847–852
(15 June 2006); doi:10.1038/nature04817
| Summary | Full Text (HTML / PDF) |

news and views
Structural biology: Images from the surface of HIV
Dennis R. Burton
Nature 441, 817–818
(15 June 2006); doi:10.1038/441817a
| Full Text (HTML / PDF) |

letter
Loss of autophagy in the central nervous system causes neurodegeneration in mice
Masaaki Komatsu, Satoshi Waguri, Tomoki Chiba, Shigeo Murata, Jun-ichi Iwata, Isei Tanida, Takashi Ueno, Masato Koike, Yasuo Uchiyama, Eiki Kominami and Keiji Tanaka
Nature 441, 880–884
(15 June 2006); doi:10.1038/nature04723
| First Paragraph | Full Text (HTML / PDF) |

letter
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Taichi Hara, Kenji Nakamura, Makoto Matsui, Akitsugu Yamamoto, Yohko Nakahara, Rika Suzuki-Migishima, Minesuke Yokoyama, Kenji Mishima, Ichiro Saito, Hideyuki Okano and Noboru Mizushima
Nature 441, 885–889
(15 June 2006); doi:10.1038/nature04724
| First Paragraph | Full Text (HTML / PDF) |

news and views
Neurodegeneration: Good riddance to bad rubbish
Daniel J. Klionsky
Nature 441, 819–820
(15 June 2006); doi:10.1038/441819a
| Full Text (HTML / PDF) |

letter
Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells
Matthew A. Williams, Aaron J. Tyznik and Michael J. Bevan
Nature 441, 890–893
(15 June 2006); doi:10.1038/nature04790
| First Paragraph | Full Text (HTML / PDF) |

letter
CRD-BP mediates stabilization of ßTrCP1 and c-myc mRNA in response to ß-catenin signalling
Felicite K. Noubissi, Irina Elcheva, Neehar Bhatia, Abbas Shakoori, Andrei Ougolkov, Jianghuai Liu, Toshinari Minamoto, Jeff Ross, Serge Y. Fuchs and Vladimir S. Spiegelman
Nature 441, 898–901
(15 June 2006); doi:10.1038/nature04839
| First Paragraph | Full Text (HTML / PDF) |

letter
Drosophila Pins-binding protein Mud regulates spindle-polarity coupling and centrosome organization
Yasushi Izumi, Nao Ohta, Kanako Hisata, Thomas Raabe & Fumio Matsuzaki
Nature Cell Biology 8, 586–593
(June 2006); doi:10.1038/ncb1409
| First Paragraph | Full Text (HTML / PDF) |

letter
The NuMA-related Mud protein binds Pins and regulates spindle orientation in Drosophila neuroblasts
Karsten H. Siller, Clemens Cabernard & Chris Q. Doe
Nature Cell Biology 8, 594–600
(June 2006); doi:10.1038/ncb1412
| First Paragraph | Full Text (HTML / PDF) |

article
Quantitative proteomic analysis of B cell lipid rafts reveals that ezrin regulates antigen receptor-mediated lipid raft dynamics
Neetu Gupta, Bernd Wollscheid, Julian D Watts, Barbara Scheer, Ruedi Aebersold & Anthony L DeFranco
Nature Immunology 7, 625–633
(June 2006); doi:10.1038/ni1337
| First Paragraph | Full Text (HTML / PDF) |

brief communication
Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke
Thiruma V Arumugam, Sic L Chan, Dong-Gyu Jo, Gokhan Yilmaz, Sung-Chun Tang, Aiwu Cheng, Marc Gleichmann, Eitan Okun, Vishwa D Dixit, Srinivasulu Chigurupati, Mohamed R Mughal, Xin Ouyang, Lucio Miele, Tim Magnus, Suresh Poosala, D Neil Granger & Mark P Mattson
Nature Medicine 12, 621–623
(June 2006); doi:10.1038/nm1403
| First Paragraph | Full Text (HTML / PDF) |

letter
The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4
John A Sayer, Edgar A Otto, John F O'Toole, Gudrun Nurnberg, Michael A Kennedy, Christian Becker, Hans Christian Hennies, Juliana Helou, Massimo Attanasio, Blake V Fausett, Boris Utsch, Hemant Khanna, Yan Liu, Iain Drummond, Isao Kawakami, Takehiro Kusakabe, Motoyuki Tsuda, Li Ma, Hwankyu Lee, Ronald G Larson, Susan J Allen, Christopher J Wilkinson, Erich A Nigg, Chengchao Shou, Concepcion Lillo, David S Williams, Bernd Hoppe, Markus J Kemper, Thomas Neuhaus, Melissa A Parisi, Ian A Glass, Marianne Petry, Andreas Kispert, Joachim Gloy, Athina Ganner, Gerd Walz, Xueliang Zhu, Daniel Goldman, Peter Nurnberg, Anand Swaroop, Michel R Leroux & Friedhelm Hildebrandt
Nature Genetics 38, 674–681
(June 2006); doi:10.1038/ng1786
| First Paragraph | Full Text (HTML / PDF) |

article
Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells
Yuqin Yin, Michael T Henzl, Barbara Lorber, Toru Nakazawa, Tommy T Thomas, Fan Jiang, Robert Langer & Larry I Benowitz
Nature Neuroscience 9, 843–852
(June 2006); doi:10.1038/nn1701
| First Paragraph | Full Text (HTML / PDF) |

news and views
How inflammation promotes regeneration
Marie T Filbin
Nature Neuroscience 9, 715–717
(June 2006); doi:10.1038/nn0606-715
| First Paragraph | Full Text (HTML / PDF) |

letter
Dual selection enhances the signaling specificity of a variant of the quorum-sensing transcriptional activator LuxR
Cynthia H Collins, Jared R Leadbetter & Frances H Arnold
Nature Biotechnology 24, 708–712
(June 2006); doi:10.1038/nbt1209
| First Paragraph | Full Text (HTML / PDF) |

news and views
A luxRury of synthetic signals
Stephen W Michnick
Nature Biotechnology 24, 658–660
(June 2006); doi:10.1038/nbt0606-658
| First Paragraph | Full Text (HTML / PDF) |

article
Noise-resistant and synchronized oscillation of the segmentation clock
Kazuki Horikawa, Kana Ishimatsu, Eiichi Yoshimoto, Shigeru Kondo and Hiroyuki Takeda
Nature 441, 719–723
(08 June 2006); doi:10.1038/nature04861
| Summary | Full Text (HTML / PDF) |

letter
Social interactions among epithelial cells during tracheal branching morphogenesis
Amin S. Ghabrial and Mark A. Krasnow
Nature 441, 746–749
(08 June 2006); doi:10.1038/nature04829
| First Paragraph | Full Text (HTML / PDF) |

letter
Modulation of intracortical synaptic potentials by presynaptic somatic membrane potential
Yousheng Shu, Andrea Hasenstaub, Alvaro Duque, Yuguo Yu and David A. McCormick
Nature 441, 761–765
(08 June 2006); doi:10.1038/nature04720
| First Paragraph | Full Text (HTML / PDF) |

news and views
Neurobiology: Extending influence
Eve Marder
Nature 441, 702–703
(08 June 2006); doi:10.1038/441702a
| Full Text (HTML / PDF) |

letter
Nuclear pore association confers optimal expression levels for an inducible yeast gene
Angela Taddei, Griet Van Houwe, Florence Hediger, Veronique Kalck, Fabien Cubizolles, Heiko Schober and Susan M. Gasser
Nature 441, 774–778
(08 June 2006); doi:10.1038/nature04845
| First Paragraph | Full Text (HTML / PDF) |

article
p63 regulates an adhesion programme and cell survival in epithelial cells
Danielle K. Carroll, Jason S. Carroll, Chee-Onn Leong, Fang Cheng, Myles Brown, Alea. A. Mills, Joan S. Brugge and Leif W. Ellisen
Nature Cell Biology 8, 551–561
(June 2006); doi:10.1038/ncb1420
| First Paragraph | Full Text (HTML / PDF) |

article
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1ß via Ipaf
Edward A Miao, Celia M Alpuche-Aranda, Monica Dors, April E Clark, Martin W Bader, Samuel I Miller and Alan Aderem
Nature Immunology 7, 569–575
(June 2006); doi:10.1038/ni1344
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article
Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1ß in salmonella-infected macrophages
Luigi Franchi, Amal Amer, Mathilde Body-Malapel, Thirumala-Devi Kanneganti, Nesrin Özören, Rajesh Jagirdar, Naohiro Inohara, Peter Vandenabeele, John Bertin, Anthony Coyle, Ethan P Grant and Gabriel Núñez
Nature Immunology 7, 576–582
(June 2006); doi:10.1038/ni1346
| First Paragraph | Full Text (HTML / PDF) |

article
Lysophospholipid sensing triggers secretion of flagellin from pathogenic salmonella
Naeha Subramanian and Ayub Qadri
Nature Immunology 7, 583–589
(June 2006); doi:10.1038/ni1336
| First Paragraph | Full Text (HTML / PDF) |

news and views
Cytosolic detection of flagellin: a deadly twist
Craig R Roy and Dario S Zamboni
Nature Immunology 7, 549–551
(08 June 2006); doi:10.1038/ni0606-549
| First Paragraph | Full Text (HTML / PDF) |

review article
The SIRP family of receptors and immune regulation
A. Neil Barclay and Marion H. Brown
(June 2006); doi:10.1038/nri1859
| Summary | Full Text (HTML / PDF) |

review article
Metastasis: a question of life or death
Patrick Mehlen and Alain Puisieux
Nature Reviews Cancer 6, 449–458
(June 2006); doi:10.1038/nrc1886
| Summary | Full Text (HTML / PDF) |

article
Noise in protein expression scales with natural protein abundance
Arren Bar-Even, Johan Paulsson, Narendra Maheshri, Miri Carmi, Erin O'Shea, Yitzhak Pilpel and Naama Barkai
Nature Genetics 38, 636–643
(June 2006); doi:10.1038/ng1807
| First Paragraph | Full Text (HTML / PDF) |

news and views
Predictable trends in protein noise
Craig R Roy and Dario S Zamboni
Nature Genetics 38, 610–611
(June 2006); doi:10.1038/ng0606-610
| First Paragraph | Full Text (HTML / PDF) |

article
Eph receptors are negatively controlled by protein tyrosine phosphatase receptor type O
Takafumi Shintani, Masaru Ihara, Hiraki Sakuta, Hiroo Takahashi, Ikuko Watakabe and Masaharu Noda
Nature Neuroscience 9, 761–769
(08 June 2006); doi:10.1038/nn1697
| First Paragraph | Full Text (HTML / PDF) |

article
NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21
Joseph R. Arron, Monte M. Winslow, Alberto Polleri, Ching-Pin Chang, Hai Wu, Xin Gao, Joel R. Neilson, Lei Chen, Jeremy J. Heit, Seung K. Kim, Nobuyuki Yamasaki, Tsuyoshi Miyakawa, Uta Francke, Isabella A. Graef and Gerald R. Crabtree
Nature 441, 595–600
(01 June 2006); doi:10.1038/nature04678
| Summary | Full Text (HTML / PDF) |

letter
A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT
Yousang Gwack, Sonia Sharma, Julie Nardone, Bogdan Tanasa, Alina Iuga, Sonal Srikanth, Heidi Okamura, Diana Bolton, Stefan Feske, Patrick G. Hogan and Anjana Rao
Nature 441, 646–650
(01 June 2006); doi:10.1038/nature04631
| First Paragraph | Full Text (HTML / PDF) |

news and views
Down's syndrome: Critical genes in a critical region
Charles J. Epstein
Nature 441, 582–583
(01 June 2006); doi:10.1038/441582a
| Full Text (HTML / PDF) |

letter
The inner-nuclear-envelope protein emerin regulates HIV-1 infectivity
Jean-Marc Jacque and Mario Stevenson
Nature 441, 641–645
(01 June 2006); doi:10.1038/nature04682
| First Paragraph | Full Text (HTML / PDF) |

news and views
Virology: HIV goes nuclear
Min Li and Robert Craigie
Nature 441, 581–582
(01 June 2006); doi:10.1038/441581a
| Full Text (HTML / PDF) |

letter
Hrr25-dependent phosphorylation state regulates organization of the pre-40S subunit
Thorsten Schäfer, Bohumil Maco, Elisabeth Petfalski, David Tollervey, Bettina Böttcher, Ueli Aebi and Ed Hurt
Nature 441, 651–655
(01 June 2006); doi:10.1038/nature04840
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letter
Computational redesign of endonuclease DNA binding and cleavage specificity
Justin Ashworth, James J. Havranek, Carlos M. Duarte, Django Sussman, Raymond J. Monnat Jr, Barry L. Stoddard and David Baker
Nature 441, 656–659
(01 June 2006); doi:10.1038/nature04818
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letter
Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells
Katia Ancelin, Ulrike C. Lange, Petra Hajkova, Robert Schneider, Andrew J. Bannister, Tony Kouzarides & M. Azim Surani
Published online: 14 May 2006
doi:10.1038/ncb1413
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review article
Interpreting the protein language using proteomics
Ole N. Jensen
Nature Reviews Molecular Cell Biology 7, 391–403
(June 2006); doi:10.1038/nrm1939
| Summary | Full Text (HTML / PDF) |

article
Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1
Tatsuya Saitoh, Adrian Tun-Kyi, Akihide Ryo, Masahiro Yamamoto, Greg Finn, Takashi Fujita, Shizuo Akira, Naoki Yamamoto, Kun Ping Lu & Shoji Yamaoka
Nature Immunology 7, 598–605
(June 2006); doi:10.1038/ni1347
| Summary | Full Text (HTML / PDF) |

news and views
Pin-ning down immune responses to RNA viruses
Nadege Goutagny, Martina Severa & Katherine A Fitzgerald
Nature Immunology 7, 555–557
(June 2006); doi:10.1038/ni0606-555
| Summary | Full Text (HTML / PDF) |

review article
Defensins in innate antiviral immunity
Mary E. Klotman and Theresa L. Chang
Nature Reviews Immunology 6, 447–456
(June 2006); doi:10.1038/nri1860
| Summary | Full Text (HTML / PDF) |

brief communication
Mutations in the gene encoding the PML nuclear body protein Sp110 are associated with immunodeficiency and hepatic veno-occlusive disease
Tony Roscioli, Simon T Cliffe, Donald B Bloch, Christopher G Bell, Glenda Mullan, Peter J Taylor, Maria Sarris, Joanne Wang, Jennifer A Donald, Edwin P Kirk, John B Ziegler, Ulrich Salzer, George B McDonald, Melanie Wong, Robert Lindeman & Michael F Buckley
Nature Genetics 38, 620–622
(June 2006); doi:10.1038/ng1780
| Summary | Full Text (HTML / PDF) |

review article
Addressing the problems with life-science databases for traditional uses and systems biology
Stephan Philippi and Jacob Köhler
Nature Reviews Genetics 7, 482–488
(June 2006); doi:10.1038/nrg1872
| Summary | Full Text (HTML / PDF) |

article
Syndapin I is the phosphorylation-regulated dynamin I partner in synaptic vesicle endocytosis
Victor Anggono, Karen J Smillie, Mark E Graham, Valentina A Valova, Michael A Cousin & Phillip J Robinson
Nature Neuroscience 9, 752–760
(June 2006); doi:10.1038/nn1695
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article
Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo
Xiaohai Wang, Nanhong Lou, Qiwu Xu, Guo-Feng Tian, Wei Guo Peng, Xiaoning Han, Jian Kang, Takahiro Takano & Maiken Nedergaard
Nature Neuroscience 9, 816–823
(June 2006); doi:10.1038/nn1703
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