The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.
Click here for free access to the 'Featured Articles' section, with new articles every week.
letter Strategies for mitigating an influenza pandemic
Neil M. Ferguson, Derek A. T. Cummings, Christophe Fraser, James C. Cajka, Philip C. Cooley and Donald S. Burke Nature442, 448–452
(27 July 2006); doi:10.1038/nature04795
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letter Endothelial tubes assemble from intracellular vacuoles in vivo
Makoto Kamei, W. Brian Saunders, Kayla J. Bayless, Louis Dye, George E. Davis and Brant M. Weinstein Nature442, 453–456
(27 July 2006); doi:10.1038/nature04923
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news and views Developmental biology: The hole picture
Keith Mostov and Fernando Martin-Belmonte Nature442, 363–364
(27 July 2006); doi:10.1038/442363a
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letter Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTEN
Min Zhao, Bing Song, Jin Pu, Teiji Wada, Brian Reid, Guangping Tai, Fei Wang, Aihua Guo, Petr Walczysko, Yu Gu, Takehiko Sasaki, Akira Suzuki, John V. Forrester, Henry R. Bourne, Peter N. Devreotes, Colin D. McCaig and Josef M. Penninger Nature442, 457–460
(27 July 2006); doi:10.1038/nature04925
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letter IL-23 promotes tumour incidence and growth
John L. Langowski, Xueqing Zhang, Lingling Wu, Jeanine D. Mattson, Taiying Chen, Kathy Smith, Beth Basham, Terrill McClanahan, Robert A. Kastelein and Martin Oft Nature442, 461–465
(27 July 2006); doi:10.1038/nature04808
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letter ATM stabilizes DNA double-strand-break complexes during V(D)J recombination
Andrea L. Bredemeyer, Girdhar G. Sharma, Ching-Yu Huang, Beth A. Helmink, Laura M. Walker, Katrina C. Khor, Beth Nuskey, Kathleen E. Sullivan, Tej K. Pandita, Craig H. Bassing and Barry P. Sleckman Nature442, 466–470
(27 July 2006); doi:10.1038/nature04866
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letter Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth
Anna Lasorella , Judith Stegmüller, Daniele Guardavaccaro, Guangchao Liu, Maria S. Carro, Gerson Rothschild, Luis de la Torre-Ubieta, Michele Pagano, Azad Bonni and Antonio Iavarone Nature442, 471–474
(27 July 2006); doi:10.1038/nature04895
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news and views Developmental neurobiology: A destructive switch for neurons
Peter K. Jackson Nature442, 365–366
(27 July 2006); doi:10.1038/442365a
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article Activation of the DExD/H-box protein Dbp5 by the nuclear-pore protein Gle1 and its coactivator InsP6 is required for mRNA export
Christine S. Weirich, Jan P. Erzberger, Jeffrey S. Flick, James M. Berger, Jeremy Thorner & Karsten Weis Nature Cell Biology8, 668–676
(June 2006); doi:10.1038/ncb1424
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news and views Unravelling mRNA export
Charles N. Cole & John J. Scarcelli Nature Cell Biology8, 645–647
(July 2006); doi:10.1038/ncb0706-645
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article Neutrophil direction sensing and superoxide production linked by the GTPase-activating protein GIT2
Yuichi Mazaki, Shigeru Hashimoto, Tohru Tsujimura, Masaki Morishige, Ari Hashimoto, Kosuke Aritake, Atsuko Yamada, Jin-Min Nam, Hiroshi Kiyonari, Kazuki Nakao & Hisataka Sabe Nature Immunology7, 724–731
(June 2006); doi:10.1038/ni1349
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article Natural killer cell differentiation driven by Tyro3 receptor tyrosine kinases
Anouk Caraux, Qingxian Lu, Nadine Fernandez, Sylvain Riou, James P Di Santo, David H Raulet, Greg Lemke & Claude Roth Nature Immunology7, 747–754
(June 2006); doi:10.1038/ni1353
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news and views NK cell development: Gas matters
Thierry Walzer & Eric Vivier Nature Immunology7, 702–704
(July 2006); doi:10.1038/ni0706-702
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article E2-EPF UCP targets pVHL for degradation and associates with tumor growth and metastasis
Cho-Rok Jung, Kyung-Sun Hwang, Jinsang Yoo, Won-Kyung Cho, Jin-Man Kim, Woo Ho Kim & Dong-Soo Im Nature Medicine12, 809–816
(July 2006); doi:10.1038/nm1440
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review The role of nitric oxide in tumour progression
Dai Fukumura, Satoshi Kashiwagi and Rakesh K. Jain Nature Reviews Cancer6, 521–534
(July 2006); doi:10.1038/nrc1910
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article JNK mediates pathogenic effects of polyglutamine-expanded androgen receptor on fast axonal transport
Gerardo Morfini, Gustavo Pigino, Györgyi Szebenyi, Yimei You, Sarah Pollema & Scott T Brady Nature Neuroscience9, 907–916
(June 2006); doi:10.1038/nn1717
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review Variability, compensation and homeostasis in neuron and network function
Eve Marder and Jean-Marc Goaillard Nature Neuroscience7, 563–574
(July 2006); doi:10.1038/nrn1949
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technology feature Microarrays: branching out from expression analysis
Laura Bonetta Nature Methods3, 571–578
(July 2006); doi:10.1038/nmeth0706-571
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letter Suppression of vascular permeability and inflammation by targeting of the transcription factor c-Jun
Roger G Fahmy, Alla Waldman, Guishui Zhang, Ainslie Mitchell, Nicodemus Tedla, Hong Cai, Carolyn R Geczy, Colin N Chesterman, Michael Perry & Levon M Khachigian Nature Biotechnology24, 856–863
(July 2006); doi:10.1038/nbt1225
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letter Kruppel-like factor 2 regulates thymocyte and T-cell migration
Corey M. Carlson, Bart T. Endrizzi, Jinghai Wu, Xiaojie Ding, Michael A. Weinreich, Elizabeth R. Walsh, Maqsood A. Wani, Jerry B. Lingrel, Kristin A. Hogquist and Stephen C. Jameson Nature442, 299–302
(20 July 2006); doi:10.1038/nature04882
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letter TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism
Xiaojing Pan, Sudharshan Eathiraj, Mary Munson and David G. Lambright Nature442, 303–306
(20 July 2006); doi:10.1038/nature04847
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letter The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3
Paul A. C. Cloos, Jesper Christensen, Karl Agger, Alessio Maiolica, Juri Rappsilber, Torben Antal, Klaus H. Hansen and Kristian Helin Nature442, 307–311
(20 July 2006); doi:10.1038/nature04837
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letter The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36
Robert J. Klose, Kenichi Yamane, Yangjin Bae, Dianzheng Zhang, Hediye Erdjument-Bromage, Paul Tempst, Jiemin Wong and Yi Zhang Nature442, 312–316
(20 July 2006); doi:10.1038/nature04853
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letter Atom-by-atom analysis of global downhill protein folding
Mourad Sadqi, David Fushman and Victor Muñoz Nature442, 317–321
(20 July 2006); doi:10.1038/nature04859
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article Asymmetric division and cosegregation of template DNA strands in adult muscle satellite cells
Vasily Shinin, Barbara Gayraud-Morel, Danielle Gomès & Shahragim Tajbakhsh Nature Cell Biology8, 677–682
(July 2006); doi:10.1038/ncb1425
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review EGF-ERBB signalling: towards the systems level
Ami Citri and Yosef Yarden Nature Reviews Molecular Cell Biology7, 505–516
(July 2006); doi:10.1038/nrm1962
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article Interleukin 15-dependent crosstalk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation
Seiichi Kuwajima, Taku Sato, Kazuto Ishida, Hiroyuki Tada, Hiroyuki Tezuka & Toshiaki Ohteki Nature Immunology7, 740–746
(July 2006); doi:10.1038/ni1348
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news and views Division of labor and cooperation between dendritic cells
Bali Pulendran Nature Immunology7, 699–700
(July 2006); doi:10.1038/ni0706-699
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review Neutrophil serine proteases: specific regulators of inflammation
Christine T. N. Pham Nature Reviews Immunology6, 541–550
(July 2006); doi:10.1038/nri1841
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article VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis
Betty Y Y Tam, Kevin Wei, John S Rudge, Jana Hoffman, Joceyln Holash, Sang-ki Park, Jenny Yuan, Colleen Hefner, Cecile Chartier, Jeng-Shin Lee, Shelly Jiang, Nihar R Niyak, Frans A Kuypers, Lisa Ma, Uma Sundram, Grace Wu, Joseph A Garcia, Stanley L Schrier, Jacquelyn J Maher, Randall S Johnson, George D Yancopoulos, Richard C Mulligan & Calvin J Kuo Nature Medicine7, 793–800
(July 2006); doi:10.1038/nm1428
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news and views VEGF inhibitors make blood
Christian Fischer, Peter Carmeliet & Edward M Conway Nature Medicine7, 732–734
(July 2006); doi:10.1038/nm0706-732
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letter Altered neuregulin 1-erbB4 signaling contributes to NMDA> receptor hypofunction in schizophrenia
Chang-Gyu Hahn, Hoau-Yan Wang, Dan-Sung Cho, Konrad Talbot, Raquel E Gur, Wade H Berrettini, Kalindi Bakshi, Joshua Kamins, Karin E Borgmann-Winter, Steven J Siegel, Robert J Gallop & Steven E Arnold Nature Medicine442, 824–828
(July 2006); doi:10.1038/nm1418
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news and views Schizophrenia: signals from the other side
Gerald D Fischbach Nature Medicine7, 734–1735
(July 2006); doi:10.1038/nm0706-734
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letter CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer
Daniel J Weisenberger, Kimberly D Siegmund, Mihaela Campan, Joanne Young, Tiffany I Long, Mark A Faasse, Gyeong Hoon Kang, Martin Widschwendter, Deborah Weener, Daniel Buchanan, Hoey Koh, Lisa Simms, Melissa Barker, Barbara Leggett, Joan Levine, Myungjin Kim, Amy J French, Stephen N Thibodeau, Jeremy Jass, Robert Haile & Peter W Laird Nature Genetics7, 787–793
(July 2006); doi:10.1038/ng1834
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news and views CIMPle origin for promoter hypermethylation in colorectal cancer?
Kornel Schuebel, Wei Chen & Stephen B Baylin Nature Genetics7, 738–740
(July 2006); doi:10.1038/ng0706-738
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article Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis
Min-Seon Kim, Youngmi K Pak, Pil-Geum Jang, Cherl Namkoong, Yon-Sik Choi, Jong-Chul Won, Kyung-Sup Kim, Seung-Whan Kim, Hyo-Soo Kim, Joong-Yeol Park, Young-Bum Kim, Ki-Up Lee Nature Neuroscience49, 901–906
(July 2006); doi:10.1038/nn1731
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review The distribution and targeting of neuronal voltage-gated ion channels
Helen C. Lai and Lily Y. Jan Nature Reviews Neuroscience7, 548–562
(July 2006); doi:10.1038/nrn1938
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article Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins
Alex Sigal, Ron Milo, Ariel Cohen, Naama Geva-Zatorsky, Yael Klein, Inbal Alaluf, Naamah Swerdlin, Natalie Perzov, Tamar Danon, Yuvalal Liron, Tal Raveh, Anne E Carpenter, Galit Lahav & Uri Alon Nature Methods7, 525–531
(July 2006); doi:10.1038/nmeth892
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review Targeting signal transduction as a strategy to treat inflammatory diseases
Luke A. J. O'Neill Nature Reviews Drug Discovery7, 549–563
(July 2006); doi:10.1038/nrd2070
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review Clarifying the mechanics of DNA strand exchange in meiotic recombination
Matthew J. Neale and Scott Keeney Nature442, 153–158
(13 July 2006); doi:10.1038/nature04885
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letter A germline-specific class of small RNAs binds mammalian Piwi proteins
Angélique Girard, Ravi Sachidanandam, Gregory J. Hannon and Michelle A. Carmell Nature442, 199–202
(13 July 2006); doi:10.1038/nature04917
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letter A novel class of small RNAs bind to MILI protein in mouse testes
Alexei Aravin , Dimos Gaidatzis, Sébastien Pfeffer, Mariana Lagos-Quintana, Pablo Landgraf, Nicola Iovino, Patricia Morris, Michael J. Brownstein, Satomi Kuramochi-Miyagawa, Toru Nakano, Minchen Chien, James J. Russo, Jingyue Ju, Robert Sheridan, Chris Sander, Mihaela Zavolan and Thomas Tuschl Nature442, 203–207
(13 July 2006); doi:10.1038/nature04916
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letter Three-dimensional structure of the myosin V inhibited state by cryoelectron tomography
Jun Liu, Dianne W. Taylor, Elena B. Krementsova, Kathleen M. Trybus and Kenneth A. Taylor Nature442, 208–211
(13 July 2006); doi:10.1038/nature04719
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letter The cargo-binding domain regulates structure and activity of myosin 5
Kavitha Thirumurugan, Takeshi Sakamoto, John A. Hammer III, James R. Sellers and Peter J. Knight Nature442, 212–215
(13 July 2006); doi:10.1038/nature04865
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letter Regulation of mitotic entry by microcephalin and its overlap with ATR signalling
Gemma K. Alderton, Laura Galbiati, Elen Griffith, Katharina H. Surinya, Heidemarie Neitzel, Andrew P. Jackson, Penny A. Jeggo & Mark O'Driscoll Nature Cell Biology8, 725–733
(18 June 2006); doi:10.1038/ncb1431
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letter Regulation of RNA-polymerase-II-dependent transcription by N-WASP and its nuclear-binding partners
Xiaoyang Wu, Youngdong Yoo, Nataly N. Okuhama, Philip W. Tucker, Gang Liu & Jun-Lin Guan Nature Cell Biology8, 756–753
(11 June 2006); doi:10.1038/ncb1433
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news and views Actin's latest act: polymerizing to facilitate transcription?
Erwann Vieu & Nouria Hernandez Nature Cell Biology8, 650–651
(2006); doi:10.1038/ncb0706-650
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article Fas ligand-mediated paracrine T cell regulation by the receptor NKG2D in tumor immunity
Veronika Groh, Kimberly Smythe, Zhenpeng Dai & Thomas Spies Nature Immunology7, 755–762
(28 May 2006); doi:10.1038/ni1350
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review The many paths to p38 mitogen-activated protein kinase activation in the immune system
Jonathan D. Ashwell Nature Reviews Immunology6, 532–540
(July 2006); doi:10.1038/nri1865
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article E2-EPF UCP targets pVHL for degradation and associates with tumor growth and metastasis
Cho-Rok Jung, Kyung-Sun Hwang, Jinsang Yoo, Won-Kyung Cho, Jin-Man Kim, Woo Ho Kim & Dong-Soo Im Nature Medicine12, 755–762
(02 July 2006); doi:10.1038/nm1440
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review Tumour microenvironment: TGFβ: the molecular Jekyll and Hyde of cancer
Brian Bierie and Harold L. Moses Nature Reviews Cancer6, 506–520
(July 2006); doi:10.1038/nrc1926
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article The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome
Mohammed Sebaihia, Brendan W Wren, Peter Mullany, Neil F Fairweather, Nigel Minton, Richard Stabler, Nicholas R Thomson, Adam P Roberts, Ana M Cerdeño-Tárraga, Hongmei Wang, Matthew TG Holden, Anne Wright, Carol Churcher, Michael A Quail, Stephen Baker, Nathalie Bason, Karen Brooks, Tracey Chillingworth, Ann Cronin, Paul Davis, Linda Dowd, Audrey Fraser, Theresa Feltwell, Zahra Hance, Simon Holroyd, Kay Jagels, Sharon Moule, Karen Mungall, Claire Price, Ester Rabbinowitsch, Sarah Sharp, Mark Simmonds, Kim Stevens, Louise Unwin, Sally Whithead, Bruno Dupuy, Gordon Dougan, Bart Barrell & Julian Parkhill Nature Genetics38, 779–786
(25 June 2006); doi:10.1038/ng1830
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review The neurobiology of itch
Akihiko Ikoma, Martin Steinhoff, Sonja Ständer, Gil Yosipovitch and Martin Schmelz Nature Reviews Neuroscience7, 535–547
(25 June 2006); doi:10.1038/nrn1950
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article Automated identification of SUMOylation sites using mass spectrometry and SUMmOn pattern recognition software
Patrick G A Pedrioli, Brian Raught, Xiang-Dong Zhang, Richard Rogers, John Aitchison, Michael Matunis & Ruedi Aebersold Nature Methods3, 533–539
(21 June 2006); doi:10.1038/nmeth891
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review Intracellular pattern recognition receptors in the host response
Etienne Meylan, Jürg Tschopp and Michael Karin Nature442, 39–44
(06 July 2006); doi:10.1038/nature04946
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article Selective elimination of messenger RNA prevents an incidence of untimely meiosis
Yuriko Harigaya, Hirotsugu Tanaka, Soichiro Yamanaka, Kayoko Tanaka, Yoshinori Watanabe, Chihiro Tsutsumi, Yuji Chikashige, Yasushi Hiraoka, Akira Yamashita and Masayuki Yamamoto Nature442, 45–50
(06 July 2006); doi:10.1038/nature04881
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letter Anti-apoptotic function of a microRNA encoded by the HSV-1 latency-associated transcript
A. Gupta, J. J. Gartner, P. Sethupathy, A. G. Hatzigeorgiou and N. W. Fraser Nature442, 82–85
(06 July 2006); doi:10.1038/nature04836
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letter A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling
Joanna Wysocka, Tomek Swigut, Hua Xiao, Thomas A. Milne, So Yeon Kwon, Joe Landry, Monika Kauer, Alan J. Tackett, Brian T. Chait, Paul Badenhorst, Carl Wu and C. David Allis Nature442, 86–90
(06 July 2006); doi:10.1038/nature04815
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letter Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF
Haitao Li, Serge Ilin, Wooikoon Wang, Elizabeth M. Duncan, Joanna Wysocka, C. David Allis and Dinshaw J. Patel Nature442, 91–95
(06 July 2006); doi:10.1038/nature04802
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article A conserved GTPase-containing complex is required for intracellular sorting of the general amino-acid permease in yeast
Minggeng Gao & Chris A. Kaiser Nature Cell Biology8, 657–667
(06 July 2006); doi:10.1038/ncb1419
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news and views Endosome sorting: GSE complex minds the Gap
Matthew N. J. Seaman Nature Cell Biology8, 648–649
(06 July 2006); doi:10.1038/ncb0706-648
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review article Reading protein modifications with interaction domains
Bruce T. Seet, Ivan Dikic, Ming-Ming Zhou and Tony Pawson Nature Reviews Molecular Cell Biology7, 473–483
(July 2006); doi:10.1038/nrm1960
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article Regulation of naive T cell function by the NF-κB2 pathway
Naozumi Ishimaru, Hidehiro Kishimoto, Yoshio Hayashi & Jonathan Sprent Nature Immunology7, 763–772
(July 2006); doi:10.1038/ni1351
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review article Genetic defects in the human glycome
Hudson H. Freeze Nature Reviews Genetics7, 537–551
(July 2006); doi:10.1038/nrg1894
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article AMPA receptors regulate transcription of the plasticity-related immediate-early gene Arc
Vikram R Rao, Sean A Pintchovski, Jeannie Chin, Carol L Peebles, Siddhartha Mitra & Steven Finkbeiner Nature Neuroscience7, 887–895
(July 2006); doi:10.1038/nn1708
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article Monitoring dynamic protein interactions with photoquenching FRET
Ignacio A Demarco, Ammasi Periasamy, Cynthia F Booker & Richard N Day Nature Methods3, 519–524
(July 2006); doi:10.1038/nmeth889
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