The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.
Click here for free access to the 'Featured Articles' section, with new articles every week.
article RecA acts in trans to allow replication of damaged DNA by DNA polymerase V
Katharina Schlacher, Michael M. Cox, Roger Woodgate and Myron F. Goodman Nature442, 883–887
(24 August 2006); doi:10.1038/nature05042
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letter Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17
Matt Baker, Ian R. Mackenzie, Stuart M. Pickering-Brown , Jennifer Gass, Rosa Rademakers, Caroline Lindholm, Julie Snowden, Jennifer Adamson, A. Dessa Sadovnick, Sara Rollinson, Ashley Cannon, Emily Dwosh, David Neary, Stacey Melquist, Anna Richardson, Dennis Dickson, Zdenek Berger, Jason Eriksen, Todd Robinson, Cynthia Zehr, Chad A. Dickey, Richard Crook, Eileen McGowan, David Mann, Bradley Boeve, Howard Feldman and Mike Hutton Nature442, 916–919
(24 August 2006); doi:10.1038/nature05016
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letter Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21
Marc Cruts , Ilse Gijselinck , Julie van der Zee , Sebastiaan Engelborghs , Hans Wils , Daniel Pirici , Rosa Rademakers , Rik Vandenberghe, Bart Dermaut, Jean-Jacques Martin, Cornelia van Duijn, Karin Peeters , Raf Sciot, Patrick Santens, Tim De Pooter , Maria Mattheijssens , Marleen Van den Broeck , Ivy Cuijt , Krist'l Vennekens , Peter P. De Deyn , Samir Kumar-Singh and Christine Van Broeckhoven Nature442, 920–924
(24 August 2006); doi:10.1038/nature05017
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letter NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus
Ayumu Tashiro, Vladislav M. Sandler, Nicolas Toni, Chunmei Zhao and Fred H. Gage Nature442, 929–933
(24 August 2006); doi:10.1038/nature05028
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letter Signal sequence directs localized secretion of bacterial surface proteins
Fredric Carlsson, Margaretha Stålhammar-Carlemalm, Klas Flärdh, Charlotta Sandin, Eric Carlemalm and Gunnar Lindahl Nature442, 943–946
(24 August 2006); doi:10.1038/nature05021
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letter Mechanism limiting centrosome duplication to once per cell cycle
Meng-Fu Bryan Tsou and Tim Stearns Nature442, 947–951
(24 August 2006); doi:10.1038/nature04985
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letter A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signalling
Lara Fallon, Catherine M.L. Bélanger, Amadou T. Corera, Maria Kontogiannea, Elsa Regan-Klapisz, France Moreau, Jarno Voortman, Michael Haber, Geneviève Rouleau, Thorhildur Thorarinsdottir, Alexis Brice, Paul M.P. van Bergen en Henegouwen & Edward A. Fon Nature Cell Biology8, 834–842
(August 2006); doi:10.1038/ncb1441
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news and views EGFR trafficking: parkin' in a jam
Koraljka Husnjak & Ivan Dikic Nature Cell Biology8, 787–788
(August 2006); doi:10.1038/ncb0806-787
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letter Critical role for Daxx in regulating Mdm2
Jun Tang, Li-Ke Qu, Jianke Zhang, Wenge Wang, Jennifer S. Michaelson, Yan Y. Degenhardt, Wafik S. El-Deiry & Xiaolu Yang Nature Cell Biology8, 855–862
(August 2006); doi:10.1038/ncb1442
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news and views Balancing Mdm2 — a Daxx-HAUSP matter
Ze'ev Ronai Nature Cell Biology8, 790–791
(August 2006); doi:10.1038/ncb0806-790
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perspective Proteome chips for whole-organism assays
Li A. Kung and Michael Snyder Nature Reviews Molecular Cell Biology7, 617–622
(August 2006); doi:10.1038/nrm1941
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article The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function
Yisong Y Wan, Hongbo Chi, Min Xie, Michael D Schneider & Richard A Flavell Nature Immunology7, 851–858
(August 2006); doi:10.1038/ni1355
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letter Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma
Premal H Thaker, Liz Y Han, Aparna A Kamat, Jesusa M Arevalo, Rie Takahashi, Chunhua Lu, Nicholas B Jennings, Guillermo Armaiz-Pena, James A Bankson, Murali Ravoori, William M Merritt, Yvonne G Lin, Lingegowda S Mangala, Tae Jin Kim, Robert L Coleman, Charles N Landen, Yang Li, Edward Felix, Angela M Sanguino, Robert A Newman, Mary Lloyd, David M Gershenson, Vikas Kundra, Gabriel Lopez-Berestein, Susan K Lutgendorf, Steven W Cole & Anil K Sood Nature Medicine12, 939–954
(August 2006); doi:10.1038/nm1447
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letter Connexin37 protects against atherosclerosis by regulating monocyte adhesion
Cindy W Wong, Thomas Christen, Isabelle Roth, Christos E Chadjichristos, Jean-Paul Derouette, Bernard F Foglia, Marc Chanson, Daniel A Goodenough & Brenda R Kwak Nature Medicine12, 950–954
(August 2006); doi:10.1038/nm1441
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letter ErbB2 receptor tyrosine kinase signaling mediates early demyelination induced by leprosy bacilli
Nikos Tapinos, Makoto Ohnishi & Anura Rambukkana Nature Medicine12, 961–966
(August 2006); doi:10.1038/nm1433
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letter Probing long-distance regulatory interactions in the Drosophila melanogaster bithorax complex using Dam identification
Fabienne Cléard, Yuri Moshkin, François Karch & Robert K Maeda Nature Genetics12, 931–935
(August 2006); doi:10.1038/ng1833
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article BDNF-mediated neurotransmission relies upon a myosin VI motor complex
Hiroko Yano, Ipe Ninan, Hong Zhang, Teresa A Milner, Ottavio Arancio & Moses V Chao Nature Neuroscience12, 1009–1018
(August 2006); doi:10.1038/nn1730
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review Chemical labeling strategies for cell biology
Kevin M Marks & Garry P Nolan Nature Methods12, 591–596
(August 2006); doi:10.1038/nmeth906
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article PML inhibits HIF-1α translation and neoangiogenesis through repression of mTOR
Rosa Bernardi, Ilhem Guernah, David Jin, Silvia Grisendi, Andrea Alimonti, Julie Teruya-Feldstein, Carlos Cordon-Cardo, M. Celeste Simon, Shahin Rafii and Pier Paolo Pandolfi Nature442, 779–785
(10 August 2006); doi:10.1038/nature05029
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letter Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology
Yong Kim, Jee Young Sung, Ilaria Ceglia, Ko-Woon Lee, Jung-Hyuck Ahn, Jonathan M. Halford, Amie M. Kim, Seung P. Kwak, Jong Bae Park, Sung Ho Ryu, Annette Schenck, Barbara Bardoni, John D. Scott, Angus C. Nairn and Paul Greengard Nature442, 814–817
(10 August 2006); doi:10.1038/nature04976
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letter Transformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9
Andrei V. Krivtsov, David Twomey, Zhaohui Feng, Matthew C. Stubbs, Yingzi Wang, Joerg Faber, Jason E. Levine, Jing Wang, William C. Hahn, D. Gary Gilliland, Todd R. Golub and Scott A. Armstrong Nature442, 818–822
(10 August 2006); doi:10.1038/nature04976
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letter Notch signalling regulates stem cell numbers in vitro and in vivo
Andreas Androutsellis-Theotokis, Ronen R. Leker, Frank Soldner, Daniel J. Hoeppner, Rea Ravin, Steve W. Poser, Maria A. Rueger, Soo-Kyung Bae, Raja Kittappa and Ronald D. G. McKay Nature442, 823–826
(10 August 2006); doi:10.1038/nature04940
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article FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling
Yasutaka Ohta, John H. Hartwig & Thomas P. Stossel Nature Cell Biology8, 803–814
(10 August 2006); doi:10.1038/ncb1437
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news and views Front and back by Rho and Rac
Keith Burridge & Renee Doughman Nature Cell Biology8, 781–782
(10 August 2006); doi:10.1038/ncb0806-781
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review Bacterial elicitation and evasion of plant innate immunity
Robert B. Abramovitch, Jeffrey C. Anderson and Gregory B. Martin Nature Review Molecular Cell Biology7, 601–611
(10 August 2006); doi:10.1038/nrm1984
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article Signaling protein SWAP-70 is required for efficient B cell homing to lymphoid organs
Glen Pearce, Veronique Angeli, Gwendalyn J Randolph, Tobias Junt, Ulrich von Andrian, Hans-Joachim Schnittler & Rolf Jessberger Nature Immunology7, 827–834
(10 August 2006); doi:10.1038/ni1365
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review Tracking STAT nuclear traffic
Nancy C. Reich and Ling Liu Nature Review Immunology6, 602–612
(10 August 2006); doi:10.1038/nri1885
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article Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness
Jolanta M Topczewska, Lynne-Marie Postovit, Naira V Margaryan, Anthony Sam, Angela R Hess, William W Wheaton, Brian J Nickoloff, Jacek Topczewski & Mary J C Hendrix Nature Medicine12, 925–932
(10 August 2006); doi:10.1038/nm1448
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news and views Embryogenesis meets tumorigenesis
John T Lee & Meenhard Herlyn Nature Medicine12, 882–884
(10 August 2006); doi:10.1038/nm0806-882
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letter Interaction of KAI1 on tumor cells with DARC on vascular endothelium leads to metastasis suppression
Sucharita Bandyopadhyay, Rui Zhan, Asok Chaudhuri, Misako Watabe, Sudha K Pai, Shigeru Hirota, Sadahiro Hosobe, Taisei Tsukada, Kunio Miura, Yukio Takano, Ken Saito, Mary E Pauza, Sunao Hayashi, Ying Wang, Sonia Mohinta, Tomoyuki Mashimo, Megumi Iiizumi, Eiji Furuta & Kounosuke Watabe Nature Medicine12, 933–938
(10 August 2006); doi:10.1038/nm1444
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news and views Stopping cancer before it colonizes
Carrie W Rinker-Schaeffer & Jonathan A Hickson Nature Medicine12, 887–888
(10 August 2006); doi:10.1038/nm0806-887
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article Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice
Pengyuan Liu, Yian Wang, Haris Vikis, Anna Maciag, Daolong Wang, Yan Lu, Yan Liu & Ming You Nature Genetics38, 888–895
(10 August 2006); doi:10.1038/ng1849
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review The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
Jeffrey A. Engelman, Ji Luo and Lewis C. Cantley Nature Review Genetics7, 606–619
(10 August 2006); doi:10.1038/nrg1879
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article Vesicular proteins exocytosed and subsequently retrieved by compensatory endocytosis are nonidentical
Martin Wienisch & Jurgen Klingauf Nature Neurosceince9, 1019–1027
(10 August 2006); doi:10.1038/nn1739
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article Proteasome-dependent degradation of Est1p regulates the cell cycle–restricted assembly of telomerase in Saccharomyces cerevisiae
Jennifer L Osterhage, Jennell M Talley & Katherine L Friedman Nature Strcutural & Molecular Biology9, 720–728
(10 August 2006); doi:10.1038/nsmb1125
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article A second class of chemosensory receptors in the olfactory epithelium
Stephen D. Liberles and Linda B. Buck Nature442, 645–650
(10 August 2006); doi:10.1038/nature05066
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news and views Neuroscience: An extra dimension to olfaction
John Ngai Nature442, 637–638
(10 August 2006); doi:10.1038/nature05001
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article Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity
Olaf Gross, Andreas Gewies, Katrin Finger, Martin Schäfer, Tim Sparwasser, Christian Peschel, Irmgard Förster and Jürgen Ruland Nature442, 651–656
(10 August 2006); doi:10.1038/nature04926
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letter Mesodermal Wnt2b signalling positively regulates liver specification
Elke A. Ober, Heather Verkade, Holly A. Field and Didier Y. R. Stainier Nature442, 688–691
(10 August 2006); doi:10.1038/nature04888
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letter Enzymatic activation of voltage-gated potassium channels
Yajamana Ramu, Yanping Xu and Zhe Lu Nature442, 696–699
(10 August 2006); doi:10.1038/nature04880
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letter An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis
Fajun Yang , Bryan W. Vought, John S. Satterlee, Amy K. Walker, Z.-Y. Jim Sun, Jennifer L. Watts, Rosalie DeBeaumont, R. Mako Saito , Sven G. Hyberts, Shaosong Yang , Christine Macol , Lakshmanan Iyer, Robert Tjian, Sander van den Heuvel , Anne C. Hart, Gerhard Wagner and Anders M. Näär Nature442, 700–704
(10 August 2006); doi:10.1038/nature04942
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article The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl–Crk pathway
Nicole K. Noren, Gabriele Foos, Craig A. Hauser & Elena B. Pasquale Nature Cell Biology8, 815–825
(10 August 2006); doi:10.1038/ncb1438
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news and views Eph tumour suppression: the dark side of Gleevec
Jean Y. J. Wang Nature Cell Biology8, 785–786
(10 August 2006); doi:10.1038/ncb0806-785
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letter SPPL2a and SPPL2b promote intramembrane proteolysis of TNFα in activated dendritic cells to trigger IL-12 production
Elena Friedmann, Ehud Hauben, Kerstin Maylandt, Simone Schleeger, Sarah Vreugde, Stefan F. Lichtenthaler, Peer-Hendrik Kuhn, Daniela Stauffer, Giorgio Rovelli & Bruno Martoglio Nature Cell Biology8, 843–848
(10 August 2006); doi:10.1038/ncb1440
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review Regulation of cardiac hypertrophy by intracellular signalling pathways
Joerg Heineke and Jeffery D. Molkentin Nature Reviews Molecular Cell Biology7, 589–600
(August 2006); doi:10.1038/nrm1983
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article Herpes simplex virus evades natural killer T cell recognition by suppressing CD1d recycling
Weiming Yuan, Anindya Dasgupta & Peter Cresswell Nature Immunology7, 835–842
(August 2006); doi:10.1038/ni1364
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news and views Viral evasion of antigen presentation: not just for peptides anymore
Luc Van Kaer & Sebastian Joyce Nature Immunology7, 795–797
(August 2006); doi:10.1038/ni0806-795
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article Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways
Ben Lehner, Catriona Crombie, Julia Tischler, Angelo Fortunato & Andrew G Fraser Nature Genetics38, 896–903
(August 2006); doi:10.1038/ng1844
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news and views From worm genetic networks to complex human diseases
Howard Bussey, Brenda Andrews & Charles Boone Nature Genetics38, 862–863
(August 2006); doi:10.1038/ng0806-862
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reviews Standards for systems biology
Alvis Brazma, Maria Krestyaninova and Ugis Sarkans Nature Review Genetics7, 593–605
(August 2006); doi:10.1038/nrg1922
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article G(o) signaling is required for Drosophila associative learning
Jacob Ferris, Hong Ge, Lingzhi Liu & Gregg Roman Nature Review Genetics9, 1036–1040
(August 2006); doi:10.1038/nn1738
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article Enrichment of regulatory CD4+CD25+ T cells by inhibition of phospholipase D signaling
Nagendra Singh, Yoichi Seki, Mariko Takami, Babak Baban, Phil R Chandler, Davood Khosravi, Xiangjian Zheng, Mayuko Takezaki, Jeffrey R Lee, Andrew L Mellor, Wendy B Bollag & Makio Iwashima Nature Methods3, 629–636
(August 2006); doi:10.1038/nmeth903
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review P2X receptors as cell-surface ATP sensors in health and disease
Baljit S. Khakh and R. Alan North Nature442, 527–532
(02 August 2006); doi:10.1038/nature04886
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article Dissecting self-renewal in stem cells with RNA interference
Natalia Ivanova, Radu Dobrin, Rong Lu, Iulia Kotenko, John Levorse, Christina DeCoste, Xenia Schafer, Yi Lun and Ihor R. Lemischka Nature442, 533–538
(02 August 2006); doi:10.1038/nature04915
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letter Tumorigenic transformation by CPI-17 through inhibition of a merlin phosphatase
Hongchuan Jin, Tobias Sperka, Peter Herrlich and Helen Morrison Nature442, 576–579
(02 August 2006); doi:10.1038/nature04856
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letter Spatial control of actin organization at adherens junctions by a synaptotagmin–like protein
Fanny Pilot, Jean-Marc Philippe, Céline Lemmers and Thomas Lecuit Nature442, 580–584
(02 August 2006); doi:10.1038/nature04935
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letter Negative regulation of ERK activity by VRK3-mediated activation of VHR phosphatase
Tae-Hong Kang & Kyong-Tai Kim Nature Cell Biology8, 863–869
(27 July 2006); doi:10.1038/ncb1447
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article The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing
Maria-Carla Saleh, Ronald P. van Rij, Armin Hekele, Amethyst Gillis, Edan Foley, Patrick H. O'Farrell & Raul Andino Nature Cell Biology7, 793–802
(27 July 2006); doi:10.1038/ncb1439
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review Retrograde transport from endosomes to the trans-Golgi network
Juan S. Bonifacino and Raul Rojas Nature Reviews Molecular Cell Biology7, 568–579
(August 2006); doi:10.1038/nrm1985
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article Auxiliary splice factor U2AF26 and transcription factor Gfi1 cooperate directly in regulating CD45 alternative splicing
Florian Heyd, Gerdy ten Dam & Tarik Möröy Nature Immunology7, 859–867
(August 2006); doi:10.1038/ni1361
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article Foxp1 is an essential transcriptional regulator of B cell development
Hui Hu, Bin Wang, Madhuri Borde, Julie Nardone, Shan Maika, Laura Allred, Philip W Tucker & Anjana Rao Nature Immunology7, 819–826
(August 2006); doi:10.1038/ni1358
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news and views FOXtrot and RAGtime in B cells
Fabio Savarese & Rudolf Grosschedl Nature Immunology7, 793–794
(August 2006); doi:10.1038/ni0806-793
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review The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design
Thomas A. Waldmann Nature Reviews Immunology6, 595–601
(August 2006); doi:10.1038/nri1901
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review Targeting the mechanisms of tumoral immune tolerance with small-molecule inhibitors
Alexander J. Muller and Peggy A. Scherle Nature Reviews Cancer6, 613–625
(August 2006); doi:10.1038/nrc1929
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article Genome-wide genetic association of complex traits in heterogeneous stock mice
William Valdar, Leah C Solberg, Dominique Gauguier, Stephanie Burnett, Paul Klenerman, William O Cookson, Martin S Taylor, J Nicholas P Rawlins, Richard Mott & Jonathan Flint Nature Genetics38, 879–887
(August 2006); doi:10.1038/ng1840
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brief communication UNC5A promotes neuronal apoptosis during spinal cord development independent of netrin-1
Megan E Williams, Xiaowei Lu, William L McKenna, Raesha Washington, Adam Boyette, Phyllis Strickland, Allison Dillon, Zaven Kaprielian, Marc Tessier-Lavigne & Lindsay Hinck Nature Neuroscience9, 996–998
(August 2006); doi:10.1038/nn1736
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article A comprehensive library of fluorescent transcriptional reporters for Escherichia coli
Alon Zaslaver, Anat Bren, Michal Ronen, Shalev Itzkovitz, Ilya Kikoin, Seagull Shavit, Wolfram Liebermeister, Michael G Surette & Uri Alon Nature Methods3, 623–638
(August 2006); doi:10.1038/nmeth895
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article High-throughput screening methodology for the directed evolution of glycosyltransferases
Amir Aharoni, Karena Thieme, Cecilia P C Chiu, Sabrina Buchini, Luke L Lairson, Hongming Chen, Natalie C J Strynadka, Warren W Wakarchuk & Stephen G Withers Nature Methods3, 609–614
(August 2006); doi:10.1038/nmeth899
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