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Research library: browse by date

September 2006

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The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.

Click here for free access to the 'Featured Articles' section, with new articles every week.

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article
Evolution of alternative transcriptional circuits with identical logic
Annie E. Tsong , Brian B. Tuch , Hao Li and Alexander D. Johnson
Nature 443, 415–420
(28 September 2006); doi:10.1038/nature05099
| Summary | Full Text (HTML / PDF) |

letter
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing
Anna V. Molofsky, Shalom G. Slutsky, Nancy M. Joseph, Shenghui He, Ricardo Pardal, Janakiraman Krishnamurthy, Norman E. Sharpless and Sean J. Morrison
Nature 443, 448–452
(28 September 2006); doi:10.1038/nature05091
| First Paragraph | Full Text (HTML / PDF) |

letter
p16INK4a induces an age-dependent decline in islet regenerative potential
Janakiraman Krishnamurthy, Matthew R. Ramsey, Keith L. Ligon, Chad Torrice, Angela Koh, Susan Bonner-Weir and Norman E. Sharpless
Nature 443, 453–457
(28 September 2006); doi:10.1038/nature05092
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news and views
Ageing: Balancing regeneration and cancer
Christian M Beausejour and Judith Campisi
Nature AOP (27 September 2006); doi:10.1038/nature05221
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letter
BRX mediates feedback between brassinosteroid levels and auxin signalling in root growth
Céline F. Mouchel, Karen S. Osmont and Christian S. Hardtke
Nature 443, 458–461
(28 September 2006); doi:10.1038/nature05130
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letter
Centrosome polarization delivers secretory granules to the immunological synapse
Jane C. Stinchcombe, Endre Majorovits, Giovanna Bossi, Stephen Fuller and Gillian M. Griffiths
Nature 443, 462–465
(28 September 2006); doi:10.1038/nature05071
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letter
Ion permeation through the Na+,K+-ATPase
Nicolás Reyes and David C. Gadsby
Nature 443, 470–474
(28 September 2006); doi:10.1038/nature05129
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letter
Sequential functioning of the ECT-2 RhoGEF, RHO-1 and CDC-42 establishes cell polarity in Caenorhabditis elegans embryos
Fumio Motegi & Asako Sugimoto
Nature Cell Biology 8, 978–985
(September 2006); doi:10.1038/ncb1459
| First Paragraph | Full Text (HTML / PDF) |

letter
Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1
Tingting Yao, Ling Song, Wei Xu, George N. DeMartino, Laurence Florens, Selene K. Swanson, Michael P. Washburn, Ronald C. Conaway, Joan Weliky Conaway & Robert E. Cohen
Nature Cell Biology 8, 994–1002
(September 2006); doi:10.1038/ncb1460
| First Paragraph | Full Text (HTML / PDF) |

perspective
High-throughput fluorescence microscopy for systems biology
Rainer Pepperkok and Jan Ellenberg
Nature Reviews Molecular Cell Biology 7, 690–696
(September 2006); doi:10.1038/nrm1979
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review
IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors
Kenya Honda and Tadatsugu Taniguchi
Nature Reviews Immunology 6, 644–658
(September 2006); doi:10.1038/nri1900
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article
Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis
Adriano G Rossi, Deborah A Sawatzky, Annemieke Walker, Carol Ward, Tara A Sheldrake, Nicola A Riley, Alison Caldicott, Magdalena Martinez-Losa, Trevor R Walker, Rodger Duffin, Mohini Gray, Elvira Crescenzi, Morag C Martin, Hugh J Brady, John S Savill, Ian Dransfield & Christopher Haslett
Nature Medicine 12, 1056–1064
(September 2006); doi:10.1038/nm1468
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letter
TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis
Carolyn G King, Takashi Kobayashi, Pedro J Cejas, Taesoo Kim, Kwiyeom Yoon, Gregory K Kim, Elise Chiffoleau, Somia P Hickman, Patrick T Walsh, Laurence A Turka & Yongwon Choi
Nature Medicine 12, 1088–1092
(September 2006); doi:10.1038/nm1449
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news and views
Supressing the supressors
Pamela S Ohashi & Wen Chen Yeh
Nature Medicine 12, 1000–1002
(September 2006); doi:10.1038/nm0906-1000
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article
Molecular analysis of flies selected for aggressive behavior
Herman A Dierick & Ralph J Greenspan
Nature Genetics 38, 1023–1031
(September 2006); doi:10.1038/ng1864
| Summary | Full Text (HTML / PDF) |

analysis
JmjC-domain-containing proteins and histone demethylation
Robert J. Klose , Eric M. Kallin and Yi Zhang
Nature Reviews Genetics 7, 715–727
(September 2006); doi:10.1038/nrg1945
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article
The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface
Silvia Cappello, Alessio Attardo, Xunwei Wu, Takuji Iwasato, Shigeyoshi Itohara, Michaela Wilsch-Bräuninger, Hanna M Eilken, Michael A Rieger, Timm T Schroeder, Wieland B Huttner, Cord Brakebusch & Magdalena Götz
Nature Neuroscience 9, 1099–1107
(September 2006); doi:10.1038/nn1744
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review
Model organisms: The mighty mouse: genetically engineered mouse models in cancer drug development
Norman E. Sharpless and Ronald A. DePinho
Nature Reviews Drug Discovery 7, 741–754
(September 2006); doi:10.1038/nrd2110
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article
Crystal structure of an H/ACA box ribonucleoprotein particle
Ling Li and Keqiong Ye
Nature 443, 302–307
(21 September 2006); doi:10.1038/nature05151
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letter
A common progenitor for haematopoietic and endothelial lineages in the zebrafish gastrula
Kevin M. Vogeli, Suk-Won Jin, Gail R. Martin and Didier Y. R. Stainier
Nature 443, 337–339
(21 September 2006); doi:10.1038/nature05045
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letter
Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning
John A. D'Orazio, Tetsuji Nobuhisa, Rutao Cui, Michelle Arya, Malinda Spry, Kazumasa Wakamatsu, Vivien Igras, Takahiro Kunisada, Scott R. Granter, Emi K. Nishimura, Shosuke Ito and David E. Fisher
Nature 443, 340–344
(21 September 2006); doi:10.1038/nature05098
| Summary | Full Text (HTML / PDF) |

letter
Calcineurin/NFAT signalling regulates pancreatic β-cell growth and function
Jeremy J. Heit, Åsa A. Apelqvist, Xueying Gu, Monte M. Winslow, Joel R. Neilson, Gerald R. Crabtree and Seung K. Kim
Nature 443, 345–349
(21 September 2006); doi:10.1038/nature05097
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letter
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
Cheryl L. Day, Daniel E. Kaufmann, Photini Kiepiela, Julia A. Brown, Eshia S. Moodley, Sharon Reddy, Elizabeth W. Mackey, Joseph D. Miller, Alasdair J. Leslie, Chantal DePierres, Zenele Mncube, Jaikumar Duraiswamy, Baogong Zhu, Quentin Eichbaum, Marcus Altfeld, E. John Wherry, Hoosen M. Coovadia, Philip J. R. Goulder, Paul Klenerman, Rafi Ahmed, Gordon J. Freeman and Bruce D. Walker
Nature 443, 350–354
(21 September 2006); doi:10.1038/nature05115
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letter
Prevalence of off-target effects in Drosophila RNA interference screens
Yong Ma, Adrian Creanga, Lawrence Lum and Philip A. Beachy
Nature 443, 359–363
(21 September 2006); doi:10.1038/nature05179
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letter
Phosphatidylinositol-3,4,5-trisphosphate regulates the formation of the basolateral plasma membrane in epithelial cells
Ama Gassama-Diagne, Wei Yu, Martin ter Beest, Fernando Martin-Belmonte, Arlinet Kierbel, Joanne Engel & Keith Mostov
Nature Cell Biology 8, 963–970
(2006); doi:10.1038/ncb1461
| Summary | Full Text (HTML / PDF) |

letter
PIASy mediates NEMO sumoylation and NF-κB activation in response to genotoxic stress
Angela M. Mabb, Shelly M. Wuerzberger-Davis & Shigeki Miyamoto
Nature Cell Biology 8, 986–993
(2006); doi:10.1038/ncb1458
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review
Notch signalling: a simple pathway becomes complex
Sarah J. Bray
Nature Reviews Molecular Cell Biology 7, 678–689
(September 2006); doi:10.1038/nrm2009
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article
Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion
Koko Katagiri, Masashi Imamura & Tatsuo Kinashi
Nature Immunology 7, 919–928
(September 2006); doi:10.1038/ni1374
| Summary | Full Text (HTML / PDF) |

article
NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism
Liming Pei, Hironori Waki, Bhavapriya Vaitheesvaran, Damien C Wilpitz, Irwin J Kurland & Peter Tontonoz
Nature Medicine 12, 1048–1055
(2006); doi:10.1038/nm1471
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letter
Loss of the tumor suppressor Vhlh leads to upregulation of Cxcr4 and rapidly progressive glomerulonephritis in mice
Mei Ding, Shiying Cui, Chengjin Li, Serge Jothy, Volker Haase, Brent M Steer, Philip A Marsden, Jeffrey Pippin, Stuart Shankland, Maria Pia Rastaldi, Clemens D Cohen, Matthias Kretzler & Susan E Quaggin
Nature Medicine 12, 1081–1087
(2006); doi:10.1038/nm1460
| Summary | Full Text (HTML / PDF) |

news and views
Hypoxia pathway linked to kidney failure
Gregg L Semenza
Nature Medicine 12, 996–997
(2006); doi:10.1038/nm0906-996
| Summary | Full Text (HTML / PDF) |

letter
JAK signaling globally counteracts heterochromatic gene silencing
Song Shi, Healani C Calhoun, Fan Xia, Jinghong Li, Long Le & Willis X Li
Nature Genetics 38, 1071–1076
(2006); doi:10.1038/ng1860
| Summary | Full Text (HTML / PDF) |

news and views
A Hopscotch-chromatin connection
Aurel Betz & James E Darnell Jr
Nature Genetics 38, 977–979
(2006); doi:10.1038/ng0906-977
| Summary | Full Text (HTML / PDF) |

article
Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype
Catherine Heurteaux, Guillaume Lucas, Nicolas Guy, Malika El Yacoubi, Susanne Thümmler, Xiao-Dong Peng, Florence Noble, Nicolas Blondeau, Catherine Widmann, Marc Borsotto, Gabriella Gobbi, Jean-Marie Vaugeois, Guy Debonnel & Michel Lazdunski
Nature Neuroscience 9, 1134–1141
(2006); doi:10.1038/nn1749
| Summary | Full Text (HTML / PDF) |

news and views
TREKing toward new antidepressants
Joshua A Gordon & Rene Hen
Nature Neuroscience 9, 1081–1083
(2006); doi:10.1038/nn0906-1081
| Summary | Full Text (HTML / PDF) |

article
Crystal structures of a multidrug transporter reveal a functionally rotating mechanism
Satoshi Murakami , Ryosuke Nakashima, Eiki Yamashita, Takashi Matsumoto and Akihito Yamaguchi
Nature 443, 173–179
(14 September 2006); doi:10.1038/nature05076
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article
Structure of a bacterial multidrug ABC transporter
Roger J. P. Dawson and Kaspar P. Locher
Nature 443, 180–185
(14 September 2006); doi:10.1038/nature05155
| Summary | Full Text (HTML / PDF) |

letter
The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenance
Kazuo Emoto, Jay Z. Parrish, Lily Yeh Jan and Yuh-Nung Jan
Nature 443, 210–213
(14 September 2006); doi:10.1038/nature05090
| First Paragraph | Full Text (HTML / PDF) |

letter
The pathological response to DNA damage does not contribute to p53-mediated tumour suppression
M. A. Christophorou, I. Ringshausen, A. J. Finch, L. Brown Swigart and G. I. Evan
Nature 443, 214–217
(14 September 2006); doi:10.1038/nature05077
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letter
Structure of the insulin receptor ectodomain reveals a folded-over conformation
Neil M. McKern, Michael C. Lawrence, Victor A. Streltsov, Mei-Zhen Lou, Timothy E. Adams, George O. Lovrecz, Thomas C. Elleman, Kim M. Richards, John D. Bentley, Patricia A. Pilling, Peter A. Hoyne, Kellie A. Cartledge, Tam M. Pham, Jennifer L. Lewis, Sonia E. Sankovich, Violet Stoichevska, Elizabeth Da Silva, Christine P. Robinson, Maurice J. Frenkel, Lindsay G. Sparrow, Ross T. Fernley, V. Chandana Epa and Colin W. Ward
Nature 443, 218–221
(14 September 2006); doi:10.1038/nature05106
| First Paragraph | Full Text (HTML / PDF) |

letter
Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo
Manuela Pellegrini, Arkady Celeste, Simone Difilippantonio, Rong Guo, Weidong Wang, Lionel Feigenbaum and André Nussenzweig
Nature 443, 222–225
(14 September 2006); doi:10.1038/nature05112
| First Paragraph | Full Text (HTML / PDF) |

letter
Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai
Andriy V. Yeromin, Shenyuan L. Zhang, Weihua Jiang, Ying Yu, Olga Safrina and Michael D. Cahalan
Nature 443, 226–229
(14 September 2006); doi:10.1038/nature05108
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letter
Orai1 is an essential pore subunit of the CRAC channel
Murali Prakriya, Stefan Feske, Yousang Gwack, Sonal Srikanth, Anjana Rao and Patrick G. Hogan
Nature 443, 230–233
(14 September 2006); doi:10.1038/nature05122
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article
Plus end-specific depolymerase activity of Kip3, a kinesin-8 protein, explains its role in positioning the yeast mitotic spindle
Mohan L. Gupta Jr., Pedro Carvalho, David M. Roof and David Pellman
Nature Cell Biology 8, 913–923
(2006); doi:10.1038/ncb1457
| Summary | Full Text (HTML / PDF) |

letter
Yeast kinesin-8 depolymerizes microtubules in a length-dependent manner
Vladimir Varga, Jonne Helenius, Kozo Tanaka, Anthony A. Hyman, Tomoyuki U. Tanaka and Jonathon Howard
Nature Cell Biology 8, 957–962
(2006); doi:10.1038/ncb1462
| First Paragraph | Full Text (HTML / PDF) |

review
Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all
Jesús Gil1 and Gordon Peters
Nature Reviews Molecular Cell Biology 7, 667–677
(2006); doi:10.1038/nrm1987
| Summary | Full Text (HTML / PDF) |

article
Inhibition of transcription factor NF-κB in the central nervous system ameliorates autoimmune encephalomyelitis in mice
Geert van Loo, Rossana De Lorenzi, Hauke Schmidt, Marion Huth, Alexander Mildner, Marc Schmidt-Supprian, Hans Lassmann, Marco R Prinz and Manolis Pasparakis
Nature Immunology 7, 954–961
(2006); doi:10.1038/ni1372
| Summary | Full Text (HTML / PDF) |

news and views
At once harmful and beneficial: the dual properties of NF-κB
Sawsan Youssef & Lawrence Steinman
Nature Immunology 7, 901–902
(2006); doi:10.1038/ni0906-901
| Summary | Full Text (HTML / PDF) |

opinion
Toll-like receptors as molecular switches
Nicholas J. Gay, Monique Gangloff and Alexander N. R. Weber
Nature Reviews Immunology 6, 693–698
(September 2006); doi:10.1038/nri1916
| Summary | Full Text (HTML / PDF) |

article
Adoptive transfer of T-cell precursors enhances T-cell reconstitution after allogeneic hematopoietic stem cell transplantation
Johannes L Zakrzewski, Adam A Kochman, Sydney X Lu, Theis H Terwey, Theo D Kim, Vanessa M Hubbard, Stephanie J Muriglan, David Suh, Odette M Smith, Jeremy Grubin, Neel Patel, Andrew Chow, Javier Cabrera-Perez, Radhika Radhakrishnan, Adi Diab, Miguel-Angel Perales, Gabrielle Rizzuto, Ewa Menet, Eric G Pamer, Glen Heller, Juan Carlos Zúñiga-Pflücker, Õnder Alpdogan & Marcel R M van den Brink
Nature Medicine 12, 1039–1047
(2006); doi:10.1038/nm1463
| Summary | Full Text (HTML / PDF) |

letter
Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis
Murray C H Clarke, Nichola Figg, Janet J Maguire, Anthony P Davenport, Martin Goddard, Trevor D Littlewood & Martin R Bennett
Nature Medicine 12, 1075–1080
(2006); doi:10.1038/nm1459
| First Paragraph | Full Text (HTML / PDF) |

letter
Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster
Michael Dews, Asal Homayouni, Duonan Yu, Danielle Murphy, Cinzia Sevignani, Erik Wentzel, Emma E Furth, William M Lee, Greg H Enders, Joshua T Mendell & Andrei Thomas-Tikhonenko
Nature Genetics 12, 1060–1065
(2006); doi:10.1038/ng1855
| First Paragraph | Full Text (HTML / PDF) |

article
The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design
Rupert J. Russell, Lesley F. Haire, David J. Stevens, Patrick J. Collins, Yi Pu Lin, G. Michael Blackburn, Alan J. Hay, Steven J. Gamblin and John J. Skehel
Nature 443, 45–49
(7 September 2006); doi:10.1038/nature05114
| Summary | Full Text (HTML / PDF) |

news and views
Structural biology: Antiviral drugs fit for a purpose
Ming Luo
Nature 443, 37–38
(7 September 2006); doi:10.1038/nature05003
| Full Text (HTML / PDF) |

article
Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration
Jeong Woong Lee, Kirk Beebe, Leslie A. Nangle, Jaeseon Jang, Chantal M. Longo-Guess, Susan A. Cook, Muriel T. Davisson, John P. Sundberg, Paul Schimmel and Susan L. Ackerman
Nature 443, 50–55
(7 September 2006); doi:10.1038/nature05096
| Summary | Full Text (HTML / PDF) |

news and views
Molecular biology: Sticky end in protein synthesis
Hervé Roy and Michael Ibba
Nature 443, 41–42
(7 September 2006); doi:10.1038/nature05002
| Full Text (HTML / PDF) |

letter
Soma-germline interactions coordinate homeostasis and growth in the Drosophila gonad
Lilach Gilboa and Ruth Lehmann
Nature 443, 97–100
(7 September 2006); doi:10.1038/nature05068
| Summary | Full Text (HTML / PDF) |

letter
AtSNX1 defines an endosome for auxin-carrier trafficking in Arabidopsis
Yvon Jaillais, Isabelle Fobis-Loisy, Christine Miège, Claire Rollin and Thierry Gaude
Nature 443, 106–109
(7 September 2006); doi:10.1038/nature05046
| Summary | Full Text (HTML / PDF) |

letter
Unravelling the dynamics of RNA degradation by ribonuclease II and its RNA-bound complex
Carlos Frazão, Colin E. McVey, Mónica Amblar, Ana Barbas, Clemens Vonrhein, Cecília M. Arraiano and Maria A. Carrondoe
Nature 443, 110–114
(7 September 2006); doi:10.1038/nature05080
| Summary | Full Text (HTML / PDF) |

article
CFTR regulates phagosome acidification in macrophages and alters bactericidal activity
Anke Di, Mary E. Brown, Ludmila V. Deriy, Chunying Li, Frances L. Szeto, Yimei Chen, Ping Huang, Jiankun Tong, Anjaparavanda P. Naren, Vytautas Bindokas, H. Clive Palfrey & Deborah J. Nelson
Nature Cell Biology 8, 933–934
(20 August 2006); doi:10.1038/ncb1456
| Summary | Full Text (HTML / PDF) |

news and views
CFTR: helping to acidify macrophage lysosomes
Joel Swanson
Nature Cell Biology 8, 908–909
(2006); doi:10.1038/ncb0906-908
| Summary | Full Text (HTML / PDF) |

letter
Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage
Chuangui Wang, Lihong Chen, Xinghua Hou, Zhenyu Li, Neha Kabra, Yihong Ma, Shino Nemoto, Toren Finkel, Wei Gu, W. Douglas Cress & Jiandong Chen
Nature Cell Biology 8, 1025–1031
(6 August 2006); doi:10.1038/ncb1468
| Summary | Full Text (HTML / PDF) |

review
The anaphase promoting complex/cyclosome: a machine designed to destroy
Jan-Michael Peters
Nature Reviews Molecular Cell Biology 7, 644–656
(September 2006); doi:10.1038/nrm1988
| Summary | Full Text (HTML / PDF) |

article
Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells
Marcel Batten, Ji Li, Sothy Yi, Noelyn M Kljavin, Dimitry M Danilenko, Sophie Lucas, James Lee, Frederic J de Sauvage & Nico Ghilardi
Nature Immunology 7, 929–936
(13 August 2006); doi:10.1038/ni1375
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article
Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system
Jason S Stumhofer, Arian Laurence, Emma H Wilson, Elaine Huang, Cristina M Tato, Leanne M Johnson, Alejandro V Villarino, Qiulong Huang, Akihiko Yoshimura, David Sehy, Christiaan J M Saris, John J O'Shea, Lothar Hennighausen, Matthias Ernst & Christopher A Hunter
Nature Immunology 7, 937–945
(13 August 2006); doi:10.1038/ni1376
| Summary | Full Text (HTML / PDF) |

news and views
All in the family: IL-27 suppression of TH-17 cells
John Colgan & Paul Rothmanr
Nature Immunology 7, 899–901
(2006); doi:10.1038/ni0906-899
| Summary | Full Text (HTML / PDF) |

review
Insulators: exploiting transcriptional and epigenetic mechanisms
Miklos Gaszner and Gary Felsenfeld
Nature Reviews Genetics 7, 703–713
(September 2006); doi:10.1038/nrg1925
| Summary | Full Text (HTML / PDF) |

article
Quantitative multiplexed profiling of cellular signaling networks using phosphotyrosine-specific DNA-tagged SH2 domains
Kevin Dierck, Kazuya Machida, Anja Voigt, Julian Thimm, Martin Horstmann, Walter Fiedler, Bruce J Mayer & Peter Nollau
Nature Methods 3, 737–744
(23 August 2006); doi:10.1038/nmeth917
| Summary | Full Text (HTML / PDF) |


article
Mast cells are essential intermediaries in regulatory T-cell tolerance
Li-Fan Lu, Evan F. Lind, David C. Gondek, Kathy A. Bennett, Michael W. Gleeson, Karina Pino-Lagos, Zachary A. Scott, Anthony J. Coyle, Jennifer L. Reed, Jacques Van Snick, Terry B. Strom, Xin Xiao Zheng and Randolph J. Noelle
Nature 442, 997–1002
(31 August 2006); doi:10.1038/nature05010
| Summary | Full Text (HTML / PDF) |

news and views
Immunology: Protection and privilege
Herman Waldmann
Nature 442, 987–988
(31 August 2006); doi:10.1038/nature05165
| Full Text (HTML / PDF) |

article
Karyopherin-mediated import of integral inner nuclear membrane proteins
Megan C. King, C. Patrick Lusk and Günter Blobel
Nature 442, 1003–1007
(31 August 2006); doi:10.1038/nature05075
| Summary | Full Text (HTML / PDF) |

news and views
Cell biology: Taking a turn into the nucleus
Ulrike Kutay and Petra Mühlhäusser
Nature 442, 991–992
(31 August 2006); doi:10.1038/nature05173
| Full Text (HTML / PDF) |

letter
Transgeneration memory of stress in plants
Jean Molinier, Gerhard Ries, Cyril Zipfel and Barbara Hohn
Nature 442, 1046–1049
(31 August 2006); doi:10.1038/nature05022
| First Paragraph | Full Text (HTML / PDF) |

letter
Proteolytic turnover of the Gal4 transcription factor is not required for function in vivo
Kip Nalley, Stephen Albert Johnston and Thomas Kodadek
Nature 442, 1054–1057
(31 August 2006); doi:10.1038/nature05067
| First Paragraph | Full Text (HTML / PDF) |

letter
In situ structure of the complete Treponema primitia flagellar motor
Gavin E. Murphy, Jared R. Leadbetter and Grant J. Jensen
Nature 442, 1062–1064
(31 August 2006); doi:10.1038/nature05015
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article
Cool-1 functions as an essential regulatory node for EGFreceptor- and Src-mediated cell growth
Qiyu Feng, Dan Baird, Xu Peng, Jianbin Wang, Thi Ly, Jun-Lin Guan & Richard A. Cerione
Nature Cell Biology 8, 945–956
(September 2006); doi:10.1038/ncb1453
| Summary | Full Text (HTML / PDF) |

news and views
Src transforms in a Cool way
Jeffrey R. Peterson & Jonathan Chernoff
Nature Cell Biology 8, 905–907
(September 2006); doi:10.1038/ncb0906-905
| Summary | Full Text (HTML / PDF) |

letter
Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5
Alex von Kriegsheim, Andrew Pitt, G. Joan Grindlay, Walter Kolch & Amardeep S. Dhillon
Nature Cell Biology 8, 1011–1016
(September 2006); doi:10.1038/ncb1465
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review
SNAREs - engines for membrane fusion
Reinhard Jahn and Richard H. Scheller
Nature Reviews Molecular Cell Biology 7, 631–643
(September 2006); doi:10.1038/nrm2002
| Summary | Full Text (HTML / PDF) |

article
Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling
Masahiro Yamamoto, Toru Okamoto, Kiyoshi Takeda, Shintaro Sato, Hideki Sanjo, Satoshi Uematsu, Tatsuya Saitoh, Naoki Yamamoto, Hiroaki Sakurai, Ken J Ishii, Shoji Yamaoka, Taro Kawai, Yoshiharu Matsuura, Osamu Takeuchi & Shizuo Akirar
Nature Immunology 7, 962–970
(September 2006); doi:10.1038/ni1367
| Summary | Full Text (HTML / PDF) |

news and views
E2 enzymes: expanding the 'ubi-verse' of immune signaling
Averil Ma & Emre Turer
Nature Immunology 7, 903–904
(September 2006); doi:10.1038/ni0906-903
| Summary | Full Text (HTML / PDF) |

review
Divorcing ARF and p53: an unsettled case
Charles J. Sherr
Nature Reviews Cancer 7, 663–673
(September 2006); doi:10.1038/nrc1954
| Summary | Full Text (HTML / PDF) |

article
C-terminal modulator controls Ca2+-dependent gating of Cav1.4 L-type Ca2+ channels
Anamika Singh, Daniel Hamedinger, Jean-Charles Hoda, Mathias Gebhart, Alexandra Koschak, Christoph Romanin & Jörg Striessnig
Nature Neuroscience 9, 1108–1116
(September 2006); doi:10.1038/nn1751
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