The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.
Click here for free access to the 'Featured Articles' section, with new articles every week.
article Insights into social insects from the genome of the honeybee Apis mellifera
The Honeybee Genome Sequencing Consortium et al. Nature443, 931–949
(26 October 2006); doi:10.1038/nature05260
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news and views Genomics: How to make a social insect
Edward O. Wilson Nature443, 919–920
(26 October 2006); doi:10.1038/443919a
| Full Text (HTML / PDF) |
letter Regulatory constraints in the evolution of the tetrapod limb anterior-posterior polarity
Basile Tarchini, Denis Duboule and Marie Kmita Nature443, 985–988
(26 October 2006); doi:10.1038/nature05247
| First Paragraph | Full Text (HTML / PDF) |
letter Corneal avascularity is due to soluble VEGF receptor-1
Balamurali K. Ambati, Miho Nozaki, Nirbhai Singh, Atsunobu Takeda, Pooja D. Jani, Tushar Suthar, Romulo J. C. Albuquerque, Elizabeth Richter, Eiji Sakurai, Michael T. Newcomb, Mark E. Kleinman, Ruth B. Caldwell, Qing Lin, Yuichiro Ogura, Angela Orecchia, Don A. Samuelson, Dalen W. Agnew, Judy St. Leger, W. Richard Green, Parameshwar J. Mahasreshti, David T. Curiel, Donna Kwan, Helene Marsh, Sakae Ikeda, Lucy J. Leiper, J. Martin Collinson, Sasha Bogdanovich, Tejvir S. Khurana, Masabumi Shibuya, Megan E. Baldwin, Napoleone Ferrara, Hans-Peter Gerber, Sandro De Falco, Jassir Witta, Judit Z. Baffi, Brian J. Raisler and Jayakrishna Ambati Nature443, 993–997
(26 October 2006); doi:10.1038/nature05249
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letter Neddylation of a breast cancer-associated protein recruits a class III histone deacetylase that represses NFκB-dependent transcription
Fei Gao, Jinke Cheng, Tong Shi & Edward T. H. Yeh Nature Chemical Biology8, 1171–1177
(2006); doi:10.1038/ncb1483
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review Molecular mechanisms of muscular dystrophies: old and new players
Kay E Davies and Kristen J Nowak Nature Reviews Molecular Cell Biology7, 762–773
(2006); doi:10.1038/nrm2024
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article Transcription factors TFE3 and TFEB are critical for CD40 ligand expression and thymus-dependent humoral immunity
Chongmin Huan, Matthew L Kelly, Ryan Steele, Iuliana Shapira, Susan R S Gottesman, Christopher A J Roman Nature Immunology7, 1082–1091
(2006); doi:10.1038/ni1378
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review Receptor editing in lymphocyte development and central tolerance
David Nemazee Nature Reviews Immunology6, 728–740
(October 2006); doi:10.1038/nri1939
| Summary | Full Text (HTML / PDF) |
review Adipocytokines: mediators linking adipose tissue, inflammation and immunity
Herbert Tilg and Alexander R. Moschen Nature Reviews Immunology6, 772–783
(October 2006); doi:10.1038/nri1937
| Summary | Full Text (HTML / PDF) |
review Cysteine cathepsins: multifunctional enzymes in cancer
Mona Mostafa Mohamed and Bonnie F. Sloane Nature Reviews Cancer6, 764–775
(October 2006); doi:10.1038/nrc1949
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letter Indian hedgehog is a major mediator of progesterone signaling in the mouse uterus
Kevin Lee, JaeWook Jeong, Inseok Kwak, Cheng-Tai Yu, Beate Lanske, Desi W Soegiarto, Rune Toftgard, Ming-Jer Tsai, Sophia Tsai, John P Lydon & Francesco J DeMayo Nature Genetics38, 1204–1209
(September 2006); doi:10.1038/ng1874
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article Asymmetrical beta-actin mRNA translation in growth cones mediates attractive turning to netrin-1
Kin-Mei Leung, Francisca PG van Horck, Andrew C Lin, Rachel Allison, Nancy Standart & Christine E Holt Nature Neuroscience9, 1247–1256
(September 2006); doi:10.1038/nn1775
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article An essential role for β-actin mRNA localization and translation in Ca2+-dependent growth cone guidance
Jiaqi Yao, Yukio Sasaki, Zhexing Wen, Gary J Bassell & James Q Zheng Nature Neuroscience9, 1265–1273
(September 2006); doi:10.1038/nn1773
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news and views Turning by asymmetric actin
Guo-li Ming Nature Neuroscience9, 1201–1203
(September 2006); doi:10.1038/nn1006-1201
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article Soluble adenylyl cyclase is required for netrin-1 signaling in nerve growth cones
Karen Y Wu, Jonathan H Zippin, David R Huron, Margarita Kamenetsky, Ulrich Hengst, Jochen Buck, Lonny R Levin & Samie R Jaffrey Nature Neuroscience9, 1257–1264
(September 2006); doi:10.1038/nn1767
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article Meninges control tangential migration of hem-derived Cajal-Retzius cells via CXCL12/CXCR4 signaling
Víctor Borrell & Oscar Marín Nature Neuroscience9, 1284–1293
(September 2006); doi:10.1038/nn1764
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article Bergmann glia expression of polyglutamine-expanded ataxin-7 produces neurodegeneration by impairing glutamate transport
Sara K Custer, Gwenn A Garden, Nishi Gill, Udo Rueb, Randell T Libby, Christian Schultz, Stephan J Guyenet, Thomas Deller, Lesnick E Westrum, Bryce L Sopher & Albert R La Spada Nature Neuroscience9, 1302–1311
(September 2006); doi:10.1038/nn1750
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news and views Intercellular miscommunication in polyglutamine pathogenesis
Christopher A Ross & Don W Cleveland Nature Neuroscience9, 1205–1206
(September 2006); doi:10.1038/nn1006-1205
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review Morphogen to mitogen: the multiple roles of hedgehog signalling in vertebrate neural development
Marc Fuccillo, Alexandra L. Joyner and Gord Fishell Nature Reviews Neuroscience9, 772–783
(September 2006); doi:10.1038/nrn1990
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review Novel pharmacological targets for the treatment of Parkinson's disease
Anthony H. V. Schapira , Erwan Bezard, Jonathan Brotchie, Frédéric Calon, Graham L. Collingridge, Borris Ferger, Bastian Hengerer, Etienne Hirsch , Peter Jenner, Nicolas Le Novère, José A. Obeso, Michael A. Schwarzschild, Umberto Spampinato and Giora Davidai Nature Reviews Drug Discovery5, 845–854
(October 2006); doi:10.1038/nrd2087
| Summary | Full Text (HTML / PDF) |
perspective Channelrhodopsin-2 and optical control of excitable cells
Feng Zhang, Li-Ping Wang, Edward S Boyden & Karl Deisseroth Nature Methods5, 785–792
(October 2006); doi:10.1038/nmeth936
| Summary | Full Text (HTML / PDF) |
article State-based discovery: a multidimensional screen for small-molecule modulators of EGF signaling
Mark Sevecka & Gavin MacBeath Nature Methods5, 825–831
(October 2006); doi:10.1038/nmeth931
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article The Mg-chelatase H subunit is an abscisic acid receptor
Yuan-Yue Shen, Xiao-Fang Wang, Fu-Qing Wu, Shu-Yuan Du, Zheng Cao, Yi Shang, Xiu-Ling Wang, Chang-Cao Peng, Xiang-Chun Yu, Sai-Yong Zhu, Ren-Chun Fan, Yan-Hong Xu and Da-Peng Zhang Nature443, 823–826
(19 October 2006); doi:10.1038/nature05176
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article Spatially regulated ubiquitin ligation by an ER/nuclear membrane ligase
Min Deng and Mark Hochstrasser Nature443, 827–831
(19 October 2006); doi:10.1038/nature05170
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article Meiotic regulation of the CDK activator RINGO/Speedy by ubiquitin-proteasome-mediated processing and degradation
Gustavo J. Gutierrez, Andrea Vögtlin, Ana Castro, Ingvar Ferby, Giorgia Salvagiotto, Ze'ev Ronai, Thierry Lorca & Angel R. Nebreda Nature Cell Biology8, 1084–1094
(2006); doi:10.1038/ncb1472
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letter Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1
Jinqiu Zhang, Wai-Leong Tam, Guo Qing Tong, Qiang Wu, Hsiao-Yun Chan, Boon-Seng Soh, Yuefei Lou, Jianchang Yang, Yupo Ma, Li Chai, Huck-Hui Ng, Thomas Lufkin, Paul Robson & Bing Lim Nature Cell Biology8, 1114–1123
(2006); doi:10.1038/ncb1481
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opinion SUN-domain proteins: 'Velcro' that links the nucleoskeleton to the cytoskeleton
Yonatan B. Tzur, Katherine L. Wilson and Yosef Gruenbaum Nature Reviews Molecular Cell Biology7, 782–788
(2006); doi:10.1038/nrm2003
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article Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1
Kyung-Chul Choi, Youn Sook Lee, Seunghwan Lim, Hyo Kyoung Choi, Chang-Hun Lee, Eun-Kyung Lee, Suntaek Hong, In-Hoo Kim, Seong-Jin Kim & Seok Hee Park Nature Immunology7, 1057–1065
(2006); doi:10.1038/ni1383
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article Surface-bound chemokines capture and prime T cells for synapse formation
Rachel S Friedman, Jordan Jacobelli & Matthew F Krummel Nature Immunology7, 1101–1108
(2006); doi:10.1038/ni1384
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review Reciprocal regulation between natural killer cells and autoreactive T cells
Fu-Dong Shi and Luc Van Kaer Nature Reviews Immunology6, 751–760
(2006); doi:10.1038/nri1935
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letter LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia
Julia Skokowa, Gunnar Cario, Murat Uenalan, Axel Schambach, Manuela Germeshausen, Karin Battmer, Cornelia Zeidler, Ulrich Lehmann, Matthias Eder, Christopher Baum, Rudolf Grosschedl, Martin Stanulla, Michaela Scherr & Karl Welte Nature Medicine12, 1191–1197
(2006); doi:10.1038/nm1484
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article Decidual NK cells regulate key developmental processes at the human fetal-maternal interface
Jacob Hanna, Debra Goldman-Wohl, Yaron Hamani, Inbal Avraham, Caryn Greenfield, Shira Natanson-Yaron, Diana Prus, Leonor Cohen-Daniel, Tal I Arnon, Irit Manaster, Roi Gazit, Vladimir Yutkin, Daniel Benharroch, Angel Porgador, Eli Keshet, Simcha Yagel & Ofer Mandelboim Nature Medicine12, 1065–1074
( 2006); doi:10.1038/nm1452
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letter Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis
Murray C H Clarke, Nichola Figg, Janet J Maguire, Anthony P Davenport, Martin Goddard, Trevor D Littlewood & Martin R Bennett Nature Medicine12, 1075–1080
(2006); doi:10.1038/nm1459
| Summary | Full Text (HTML / PDF) |
review Ubiquitin and ubiquitin-like proteins in cancer pathogenesis
Daniela Hoeller, Christina-Maria Hecker and Ivan Dikic Nature Reviews Cancer6, 776–788
(2006); doi:10.1038/nrc1994
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article Focal adhesion kinase signaling at sites of integrin-mediated adhesion controls axon pathfinding
Estuardo Robles & Timothy M Gomez Nature Neurology9, 1274–1283
(2006); doi:10.1038/nn1762
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letter Human C5aR knock-in mice facilitate the production and assessment of anti-inflammatory monoclonal antibodies
Hyun Lee, David Zahra, Alexis Vogelzang, Rebecca Newton, Jenny Thatcher, Annie Quan, Trina So, Jörg Zwirner, Frank Koentgen, Søren B Padkjær, Fabienne Mackay, Peter L Whitfeld & Charles R Mackay Nature Biotechnology24, 1279–1284
(2006); doi:10.1038/nbt1248
| Summary | Full Text (HTML / PDF) |
news and views Complementary therapies for inflammation
Yi Wang Nature Biotechnology24, 1224–1226
(2006); doi:10.1038/nbt1006-1224
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news and views Signalling platforms that modulate the inflammatory response: new targets for drug development
Christopher. A. McCulloch, Gregory P. Downey and Hani El-Gabalawy Nature Reviews Drug Discovery5, 864–876
(2006); doi:10.1038/nrd2109
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news and views Evidence of off-target effects associated with long dsRNAs in Drosophila melanogaster cell-based assays
Meghana M Kulkarni, Matthew Booker, Serena J Silver, Adam Friedman, Pengyu Hong, Norbert Perrimon & Bernard Mathey-Prevot Nature Methods3, 833–838
(2006); doi:10.1038/nmeth935
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letter Fast neurotransmitter release triggered by Ca influx through AMPA-type glutamate receptors
Andrés E. Chávez, Joshua H. Singer and Jeffrey S. Diamond Nature443, 705–708
(12 October 2006); doi:10.1038/nature05123
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article Role of Bax and Bak in mitochondrial morphogenesis
Mariusz Karbowski, Kristi L. Norris, Megan M. Cleland, Seon-Yong Jeong and Richard J. Youle Nature443, 658–662
(12 October 2006); doi:10.1038/nature05111
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letter Bidirectional control of CNS capillary diameter by pericytes
Claire M. Peppiatt, Clare Howarth, Peter Mobbs and David Attwell Nature443, 700–704
(12 October 2006); doi:10.1038/nature05193
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article Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway
Christophe Denoyelle, George Abou-Rjaily, Vladimir Bezrookove, Monique Verhaegen, Timothy M. Johnson, Douglas R. Fullen, Jenny N. Pointer, Stephen B. Gruber, Lyndon D. Su, Mikhail A. Nikiforov, Randal J. Kaufman, Boris C. Bastian & Maria S. Soengas Nature Cell Biology8, 1053–1063
(2006); doi:10.1038/ncb1471
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review The ARP2/3 complex: an actin nucleator comes of age
Erin D. Goley and Matthew D. Welch Nature Reviews Molecular Cell Biology7, 713–726
(2006); doi:10.1038/nrm2026
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article The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling
Michael Carty, Rory Goodbody, Martina Schröder, Julianne Stack, Paul N Moynagh & Andrew G Bowie Nature Immunology7, 1074–1081
(2006); doi:10.1038/ni1382
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news and views DisSARMing Toll-like receptor signaling
Luke A J O'Neill Nature Immunology7, 1023–1025
(2006); doi:10.1038/ni1006-1023
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review Receptor editing in lymphocyte development and central tolerance
David Nemazee Nature Reviews Immunology7, 728–740
(2006); doi:10.1038/nri1939
| Summary | Full Text (HTML / PDF) |
article NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism
Liming Pei, Hironori Waki, Bhavapriya Vaitheesvaran, Damien C Wilpitz, Irwin J Kurland & Peter Tontonoz Nature Medicine12, 1048–1055
(2006); doi:10.1038/nm1471
| Summary | Full Text (HTML / PDF) |
letter Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis
Murray C H Clarke, Nichola Figg, Janet J Maguire, Anthony P Davenport, Martin Goddard, Trevor D Littlewood & Martin R Bennett Nature Medicine12, 1075–1080
(2006); doi:10.1038/nm1459
| Summary | Full Text (HTML / PDF) |
letter TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis
Carolyn G King, Takashi Kobayashi, Pedro J Cejas, Taesoo Kim, Kwiyeom Yoon, Gregory K Kim, Elise Chiffoleau, Somia P Hickman, Patrick T Walsh, Laurence A Turka & Yongwon Choi Nature Medicine12, 1088–1092
(2006); doi:10.1038/nm1449
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article Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule
Maria D Lalioti, Junhui Zhang, Heather M Volkman, Kristopher T Kahle, Kristin E Hoffmann, Hakan R Toka, Carol Nelson-Williams, David H Ellison, Richard Flavell, Carmen J Booth, Yin Lu, David S Geller & Richard P Lifton Nature Genetics38, 1124–1132
(2006); doi:10.1038/ng1877
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brief communication Local caspase activity directs engulfment of dendrites during pruning
Darren W Williams, Shu Kondo, Agnieszka Krzyzanowska, Yasushi Hiromi & James W Truman Nature Neuroscience9, 1234–1236
(2006); doi:10.1038/nn1774
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article Analyzing proteome topology and function by automated multidimensional fluorescence microscopy
Walter Schubert, Bernd Bonnekoh, Ansgar J Pommer, Lars Philipsen, Raik Böckelmann, Yanina Malykh, Harald Gollnick, Manuela Friedenberger, Marcus Bode & Andreas W M Dress Nature Biotechnology24, 1270–1278
(2006); doi:10.1038/nbt1250
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news and views Putting proteins on the map
Robert F Murphy Nature Biotechnology24, 1223–1224
(2006); doi:10.1038/nbt1006-1223
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commentary Minimizing the risk of reporting false positives in large-scale RNAi screens
Christophe J Echeverri, Philip A Beachy, Buzz Baum, Michael Boutros, Frank Buchholz, Sumit K Chanda, Julian Downward, Jan Ellenberg, Andrew G Fraser, Nir Hacohen, William C Hahn, Aimee L Jackson, Amy Kiger, Peter S Linsley, Lawrence Lum, Yong Ma, Bernard Mathey-Prévôt, David E Root, David M Sabatini, Jussi Taipale, Norbert Perrimon & René Bernards Nature Methods3, 777–779
(2006); doi:10.1038/nmeth1006-777
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article Genome-wide genetic analysis of polyploidy in yeast
Zuzana Storchová, Amanda Breneman, Jessica Cande, Joshua Dunn, Kendra Burbank, Eileen O'Toole and David Pellman Nature443, 541–547
(05 October 2006); doi:10.1038/nature05178
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article AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP
Adrienne W. Paton, Travis Beddoe, Cheleste M. Thorpe, James C. Whisstock, Matthew C. J. Wilce, Jamie Rossjohn, Ursula M. Talbot and James C. Paton Nature443, 548–552
(05 October 2006); doi:10.1038/nature05124
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letter Identification of a mammalian mitochondrial porphyrin transporter
Partha C. Krishnamurthy, Guoqing Du, Yu Fukuda, Daxi Sun, Janardhan Sampath, Kelly E. Mercer, Junfeng Wang, Beatriz Sosa-Pineda, K. Gopal Murti and John D. Schuetz Nature443, 586–589
(05 October 2006); doi:10.1038/nature05125
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letter Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis
Shida Yousefi, Remo Perozzo, Inès Schmid, Andrew Ziemiecki, Thomas Schaffner, Leonardo Scapozza, Thomas Brunner & Hans-Uwe Simon Nature Cell Biology8, 1124–1132
(October 2006); doi:10.1038/ncb1482
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news and views Atg5: more than an autophagy factor
Patrice Codogno & Alfred J. Meijer Nature Cell Biology8, 1045–1047
(October 2006); doi:10.1038/ncb1006-1045
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review The COPII cage: unifying principles of vesicle coat assembly
Cemal Gürkan, Scott M. Stagg, Paul LaPointe and William E. Balch Nature Reviews Molecular Cell Biology7, 727–738
(October 2006); doi:10.1038/nrm2025
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article Hematopoietic stem cell and multilineage defects generated by constitutive β-catenin activation
Marina Scheller, Joerg Huelsken, Frank Rosenbauer, Makoto M Taketo, Walter Birchmeier, Daniel G Tenen & Achim Leutz Nature Immunology7, 1037–1047
(October 2006); doi:10.1038/ni1387
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article Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block
Peggy Kirstetter, Kristina Anderson, Bo T Porse, Sten Eirik W Jacobsen & Claus Nerlov Nature Immunology7, 1048–1056
(October 2006); doi:10.1038/ni1381
| Summary | Full Text (HTML / PDF) |
news and views Hematopoietic stem cell biology: too much of a Wnt thing
Jennifer J Trowbridge, Randall T Moon & Mickie Bhatia Nature Immunology7, 1021–1023
(October 2006); doi:10.1038/ni1006-1021
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review Immunological mechanisms of allergen-specific immunotherapy
Mark Larché , Cezmi A. Akdis and Rudolf Valenta Nature Reviews Immunology6, 761–771
(October 2006); doi:10.1038/nri1934
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review Mechanisms of cutaneous toxicities to EGFR inhibitors
Mario E. Lacouture Nature Reviews Cancer6, 803–812
(October 2006); doi:10.1038/nrc1970
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article Lamin B1 duplications cause autosomal dominant leukodystrophy
Quasar S Padiath, Kazumasa Saigoh, Raphael Schiffmann, Hideaki Asahara, Takeshi Yamada, Anulf Koeppen, Kirk Hogan, Louis J Ptác caronek & Ying-Hui Fu Nature Genetics38, 1114–1123
(October 2006); doi:10.1038/ng1872
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article NGL family PSD-95-interacting adhesion molecules regulate excitatory synapse formation
Seho Kim, Alain Burette, Hye Sun Chung, Seok-Kyu Kwon, Jooyeon Woo, Hyun Woo Lee, Karam Kim, Hyun Kim, Richard J Weinberg & Eunjoon Kim Nature Neuroscience9, 1294–1301
(October 2006); doi:10.1038/nn1763
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news and views Hooking up new synapses
Thomas Biederer Nature Neuroscience9, 1203–1204
(October 2006); doi:10.1038/nn1006-1203
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review Non-conducting functions of voltage-gated ion channels
Leonard K. Kaczmarek Nature Reviews Neuroscience7, 761–771
(October 2006); doi:10.1038/nrn1988
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review Discovery and development of sorafenib: a multikinase inhibitor for treating cancer
Scott Wilhelm, Christopher Carter, Mark Lynch, Timothy Lowinger, Jacques Dumas, Roger A. Smith, Brian Schwartz, Ronit Simantov and Susan Kelley Nature Reviews Drug Discovery5, 835–844
(October 2006); doi:10.1038/nrd2130
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perspective Channelrhodopsin-2 and optical control of excitable cells
Feng Zhang, Li-Ping Wang, Edward S Boyden & Karl Deisseroth Nature Methods3, 785–792
(October 2006); doi:10.1038/nmeth936
| Summary | Full Text (HTML / PDF) |
