The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.
Click here for free access to the 'Featured Articles' section, with new articles every week.
letter Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites
Alastair M. Hosie, Megan E. Wilkins, Helena M. A. da Silva and Trevor G. Smart Nature444, 486–489
(23 November 2006); doi:10.1038/nature05324
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letter Self-incompatibility in Papaver targets soluble inorganic pyrophosphatases in pollen
Barend H. J. de Graaf, Jason J. Rudd, Michael J. Wheeler, Ruth M. Perry, Elizabeth M. Bell, Kim Osman, F. Christopher H. Franklin and Vernonica E. Franklin-Tong Nature444, 490–493
(23 November 2006); doi:10.1038/nature05311
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letter CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation
Leigh Ann Higa, Min Wu, Tao Ye, Ryuji Kobayashi, Hong Sun & Hui Zhang Nature Cell Biology8, 1277–1283
(November 2006); doi:10.1038/ncb1490
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review Auxin in action: signalling, transport and the control of plant growth and development
William D. Teale, Ivan A. Paponov and Klaus Palme Nature Reviews Molecular Cell Biology7, 847–859
(November 2006); doi:10.1038/nrm2020
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article Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expression
Amiram Ariel, Gabrielle Fredman, Yee-Ping Sun, Alpdogan Kantarci, Thomas E Van Dyke, Andrew D Luster & Charles N Serhan Nature Immunology7, 1209–1216
(November 2006); doi:10.1038/ni1392
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review Toll-like receptors in systemic autoimmune disease
Ann Marshak-Rothstein Nature Reviews Immunology6, 823–835
(November 2006); doi:10.1038/nri1957
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article Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes
Neeta S Roy, Carine Cleren, Shashi K Singh, Lichuan Yang, M Flint Beal & Steven A Goldman Nature Medicine12, 1259–1268
(November 2006); doi:10.1038/nm1495
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brief communication DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis
Bettina Lorenz-Depiereux, Murat Bastepe, Anna Benet-Pagès, Mustapha Amyere, Janine Wagenstaller, Ursula Müller-Barth, Klaus Badenhoop, Stephanie M Kaiser, Roger S Rittmaster, Alan H Shlossberg, José L Olivares, César Loris, Feliciano J Ramos, Francis Glorieux, Miikka Vikkula, Harald Jüppner & Tim M Strom Nature Genetics38, 1248–1250
(November 2006); doi:10.1038/ng1868
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news and views Bone talk
Susan C Schiavi Nature Genetics38, 1230–1231
(November 2006); doi:10.1038/ng1106-1230
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article Genome-wide analysis of estrogen receptor binding sites
Jason S Carroll, Clifford A Meyer, Jun Song, Wei Li, Timothy R Geistlinger, Jérôme Eeckhoute, Alexander S Brodsky, Erika Krasnickas Keeton, Kirsten C Fertuck, Giles F Hall, Qianben Wang, Stefan Bekiranov, Victor Sementchenko, Edward A Fox, Pamela A Silver, Thomas R Gingeras, X Shirley Liu & Myles Brown Nature Genetics38, 1289–1297
(November 2006); doi:10.1038/ng1901
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article Local potassium signaling couples neuronal activity to vasodilation in the brain
Jason S Carroll, Clifford A Meyer, Jun Song, Wei Li, Timothy R Geistlinger, Jérôme Eeckhoute, Alexander S Brodsky, Erika Krasnickas Keeton, Kirsten C Fertuck, Giles F Hall, Qianben Wang, Stefan Bekiranov, Victor Sementchenko, Edward A Fox, Pamela A Silver, Thomas R Gingeras, X Shirley Liu & Myles Brown Nature Neuroscience9, 1397–1403
(November 2006); doi:10.1038/nn1779
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review The obesity pipeline: current strategies in the development of anti-obesity drugs
Dunstan Cooke and Steve Bloom Nature Revies Drug Discovery5, 919–931
(November 2006); doi:10.1038/nrd2159
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article Three-dimensional structure of the KChIP1-Kv4.3 T1 complex reveals a cross-shaped octamer
Marta Pioletti, Felix Findeisen, Greg L Hura & Daniel L Minor, Jr Nature Structural and Molecular Biology13, 987–995
(November 2006); doi:10.1038/nsmb1164
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article An efficient tandem affinity purification procedure for interaction proteomics in mammalian cells
Tilmann Bürckstümmer, Keiryn L Bennett, Adrijana Preradovic, Gregor Schütze, Oliver Hantschel, Giulio Superti-Furga & Angela Bauch Nature Methods3, 1013–1019
(November 2006); doi:10.1038/nmeth968
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article IGF-I specifically enhances axon outgrowth of corticospinal motor neurons
P Hande Özdinler & Jeffrey D Macklis Nature Neuroscience9, 1371–1381
(November 2006); doi:10.1038/nn1789
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letter A protein interaction network for pluripotency of embryonic stem cells
Jianlong Wang, Sridhar Rao, Jianlin Chu, Xiaohua Shen, Dana N. Levasseur, Thorold W. Theunissen and Stuart H. Orkin Nature444, 364–368
(16 November 2006); doi:10.1038/nature05284
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letter Boc is a receptor for sonic hedgehog in the guidance of commissural axons
Ami Okada , Frédéric Charron , Steves Morin, David S. Shin, Karen Wong, Pierre J. Fabre, Marc Tessier-Lavigne and Susan K. McConnell Nature444, 369–373
(16 November 2006); doi:10.1038/nature05246
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letter Visualization of transient encounter complexes in protein-protein association
Chun Tang, Junji Iwahara and G. Marius Clore Nature444, 383–386
(16 November 2006); doi:10.1038/nature05201
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Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control
Victoria Aranda, Teresa Haire, Marissa E. Nolan, Joseph P. Calarco, Avi Z. Rosenberg, James P. Fawcett, Tony Pawson & Senthil K. Muthuswamy Nature Cell Biology8, 1235–1245
(November 2006); doi:10.1038/ncb1485
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letter Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence
Akiko Takahashi, Naoko Ohtani, Kimi Yamakoshi, Shin-ichi Iida, Hidetoshi Tahara, Keiko Nakayama, Keiichi I. Nakayama, Toshinori Ide, Hideyuki Saya & Eiji Hara Nature Cell Biology8, 1291–1297
(November 2006); doi:10.1038/ncb1491
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news and views ROS as a tumour suppressor?
Matthew R. Ramsey & Norman E. Sharpless Nature Cell Biology8, 1213–1215
(November 2006); doi:10.1038/ncb1106-1213
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article RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development
Yi Gu, Hee-Don Chae, Jamie E Siefring, Aparna C Jasti, David A Hildeman & David A Williams Nature Immunology7, 1182–1190
(November 2006); doi:10.1038/ni1396
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article A pathway regulated by cell cycle inhibitor p27Kip1 and checkpoint inhibitor Smad3 is involved in the induction of T cell tolerance
Lequn Li, Yoshiko Iwamoto, Alla Berezovskaya & Vassiliki A Boussiotis Nature Immunology7, 1157–1165
(November 2006); doi:10.1038/ni1398
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review Apoptosis and caspases regulate death and inflammation in sepsis
Richard S. Hotchkiss and Donald W. Nicholson Nature Reviews Immunology6, 813–822
(November 2006); doi:10.1038/nri1943
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article Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage
Tong Cheng, Anthony L Petraglia, Zhang Li, Meenakshisundaram Thiyagarajan, Zhihui Zhong, Zhenhua Wu, Dong Liu, Sanjay B Maggirwar, Rashid Deane, José A Fernández, Barbra LaRue, John H Griffin, Michael Chopp & Berislav V Zlokovic Nature Medicine12, 1278–1285
(November 2006); doi:10.1038/nm1498
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letter R-spondin1 is essential in sex determination, skin differentiation and malignancy
Pietro Parma, Orietta Radi, Valerie Vidal, Marie Christine Chaboissier, Elena Dellambra, Stella Valentini, Liliana Guerra, Andreas Schedl & Giovanna Camerino Nature Genetics38, 1304–1309
(November 2006); doi:10.1038/ng1907
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brief communication The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychia
Diana C Blaydon, Yoshiyuki Ishii, Edel A O'Toole, Harriet C Unsworth, Muy-Teck Teh, Franz Rüschendorf, Claire Sinclair, Väinö K Hopsu-Havu, Nicholas Tidman, Celia Moss, Rosemarie Watson, David de Berker, Muhammad Wajid, Angela M Christiano & David P Kelsell Nature Genetics38, 1245–1247
(November 2006); doi:10.1038/ng1883
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news and views R-spondin1 tips the balance in sex determination
Blanche Capel Nature Genetics38, 1233–1234
(November 2006); doi:10.1038/ng1106-1233
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review Orchestrating ontogenesis: variations on a theme by sonic hedgehog
Philip W. Ingham and Marysia Placzek Nature Reviews Genetics7, 841–850
(November 2006); doi:10.1038/nrg1969
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review Reelin, lipoprotein receptors and synaptic plasticity
Joachim Herz and Ying Chen Nature Reviews Neuroscience7, 850–859
(November 2006); doi:10.1038/nrn2009
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review Regulation of cell fate in the sensory epithelia of the inner ear
Matthew W. Kelley Nature Reviews Neuroscience7, 837–849
(November 2006); doi:10.1038/nrn1987
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article BMP-4 is required for hepatic specification of mouse embryonic stem cell-derived definitive endoderm
Valerie Gouon-Evans, Lise Boussemart, Paul Gadue, Dirk Nierhoff, Christoph I Koehler, Atsushi Kubo, David A Shafritz & Gordon Keller Nature Biotechnology24, 1402–1411
(November 2006); doi:10.1038/nbt1258
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letter Retinal repair by transplantation of photoreceptor precursors
R. E. MacLaren , R. A. Pearson, A. MacNeil, R. H. Douglas, T. E. Salt, M. Akimoto, A. Swaroop, J. C. Sowden and R. R. Ali Nature444, 203–207
(09 November 2006); doi:10.1038/nature05161
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news and views Neurobiology: Right timing for retina repair
Thomas A. Reh Nature444, 156–157
(09 November 2006); doi:10.1038/444156a
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letter Spider toxins activate the capsaicin receptor to produce inflammatory pain
Jan Siemens, Sharleen Zhou, Rebecca Piskorowski, Tetsuro Nikai, Ellen A. Lumpkin, Allan I. Basbaum, David King and David Julius Nature444, 208–212
(09 November 2006); doi:10.1038/nature05285
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news and views Physiology: Channelled pain
Lesley Anson Nature444, 156
(09 November 2006); doi:10.1038/444156b
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letter Structure of C3b reveals conformational changes that underlie complement activity
Bert J. C. Janssen, Agni Christodoulidou, Andrew McCarthy, John D. Lambris and Piet Gros Nature444, 213–216
(09 November 2006); doi:10.1038/nature05172
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letter Structure of C3b in complex with CRIg gives insights into regulation of complement activation
Christian Wiesmann, Kenneth J. Katschke, JianPing Yin, Karim Y. Helmy, Micah Steffek, Wayne J. Fairbrother, Scott A. McCallum, Lizette Embuscado, Laura DeForge, Philip E. Hass and Menno van Lookeren Campagne Nature444, 217–220
(09 November 2006); doi:10.1038/nature05263
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letter The structure of complement C3b provides insights into complement activation and regulation
A. Abdul Ajees , K. Gunasekaran , John E. Volanakis , Sthanam. V. L. Narayana , Girish J. Kotwal and H. M. Krishna Murthy Nature444, 221–225
(09 November 2006); doi:10.1038/nature05258
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news and views Immunology: Exposure of an executioner
Michael Carroll Nature444, 159–160
(09 November 2006); doi:10.1038/nature05307
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letter Wza the translocon for E. coli capsular polysaccharides defines a new class of membrane protein
Changjiang Dong, Konstantinos Beis , Jutta Nesper, Anne L. Brunkan-LaMontagne, Bradley R. Clarke, Chris Whitfield and James H. Naismith Nature444, 226–229
(09 November 2006); doi:10.1038/nature05267
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letter A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling
Adam Friedman and Norbert Perrimon Nature444, 230–234
(09 November 2006); doi:10.1038/nature05280
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letter CD28 interaction with filamin-A controls lipid raft accumulation at the T-cell immunological synapse
Regina Tavano, Rita Lucia Contento, Sonia Jimenez Baranda, Marzia Soligo, Loretta Tuosto, Santos Manes & Antonella Viola Nature Cell Biology8, 1270–1276
(November 2006); doi:10.1038/ncb1492
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review Protein tyrosine phosphatases: from genes, to function, to disease
Nicholas K. Tonks Nature Reviews Molecular Cell Biology7, 833–846
(November 2006); doi:10.1038/nrm2039
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article T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase-α
Yuanyuan Zha, Reinhard Marks, Allen W Ho, Amy C Peterson, Sujit Janardhan, Ian Brown, Kesavannair Praveen, Stacey Stang, James C Stone & Thomas F Gajewski Nature Immunology7, 1166–1173
(November 2006); doi:10.1038/ni1394
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article Disruption of diacylglycerol metabolism impairs the induction of T cell anergy
Benjamin A Olenchock, Rishu Guo, Jeffery H Carpenter, Martha Jordan, Matthew K Topham, Gary A Koretzky & Xiao-Ping Zhong Nature Immunology7, 1174–1181
(November 2006); doi:10.1038/ni1400
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news and views Linking diacylglycerol kinase to T cell anergy
Daniel L Mueller Nature Immunology7, 1132–1134
(November 2006); doi:10.1038/ni1106-1132
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article Interleukin-10 determines viral clearance or persistence in vivo
David G Brooks, Matthew J Trifilo, Kurt H Edelmann, Luc Teyton, Dorian B McGavern & Michael B A Oldstone Nature Medicine12, 1301–1309
(November 2006); doi:10.1038/nm1492
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review MicroRNA signatures in human cancers
George A. Calin and Carlo M. Croce Nature Reviews Cancer6, 857–866
(November 2006); doi:10.1038/nrc1997
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article The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychia
Diana C Blaydon, Yoshiyuki Ishii, Edel A O'Toole, Harriet C Unsworth, Muy-Teck Teh, Franz Rüschendorf, Claire Sinclair, Väinö K Hopsu-Havu, Nicholas Tidman, Celia Moss, Rosemarie Watson, David de Berker, Muhammad Wajid, Angela M Christiano & David P Kelsell Nature Genetics12, 1301–1309
(November 2006); doi:10.1038/ng1883
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letter Regulation of primary cilia formation and left-right patterning in zebrafish by a noncanonical Wnt signaling mediator, duboraya
Isao Oishi, Yasuhiko Kawakami, Ángel Raya, Carles Callol-Massot & Juan Carlos Izpisúa Belmonte Nature Genetics38, 1316–1322
(November 2006); doi:10.1038/ng1892
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article A new strategy for structure determination of large proteins in solution without deuteration
Yingqi Xu, Yu Zheng, Jing-Song Fan & Daiwen Yang Nature Methods3, 931–937
(November 2006); doi:10.1038/nmeth938
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review PI3K γ inhibition: towards an 'aspirin of the 21st century'?
Thomas Rückle, Matthias K. Schwarz and Christian Rommel Nature Reviews Drug Discovery6, 903–918
(November 2006); doi:10.1038/nrd2145
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article Inactivation of the p53 pathway in retinoblastoma
Nikia A. Laurie, Stacy L. Donovan, Chie-Schin Shih, Jiakun Zhang, Nicholas Mills, Christine Fuller, Amina Teunisse, Suzanne Lam, Yolande Ramos, Adithi Mohan, Dianna Johnson, Matthew Wilson, Carlos Rodriguez-Galindo, Micaela Quarto, Sarah Francoz, Susan M. Mendrysa, R. Kiplin Guy, Jean-Christophe Marine, Aart G. Jochemsen and Michael A. Dyer Nature444, 61–66
(02 November 2006); doi:10.1038/nature05194
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news and views Cancer biology: Second step to retinal tumours
Valerie A. Wallace Nature444, 45–46
(02 November 2006); doi:10.1038/444045a Full Text (HTML / PDF) |
letter Two modes of fusion pore opening revealed by cell-attached recordings at a synapse
Liming He, Xin-Sheng Wu, Raja Mohan and Ling-Gang Wu Nature444, 102–105
(02 November 2006); doi:10.1038/nature05250
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letter Movement of 'gating charge' is coupled to ligand binding in a G-protein-coupled receptor
Yair Ben-Chaim, Baron Chanda, Nathan Dasca, Francisco Bezanilla, Itzchak Parnas and Hanna Parnas Nature444, 106–109
(02 November 2006); doi:10.1038/nature05259
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letter Surface expression of MHC class II in dendritic cells is controlled by regulated ubiquitination
Jeoung-Sook Shin, Melanie Ebersold, Marc Pypaert, Lelia Delamarre, Adam Hartley and Ira Mellman Nature444 115–118
(02 November 2006); doi:10.1038/nature05261
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article Molecular mechanisms of coupled monoubiquitination
Tanja Woelk, Barbara Oldrini, Elena Maspero, Stefano Confalonieri, Elena Cavallaro, Pier Paolo Di Fiore, & Simona Polo Nature Cell Biology8, 1246–1254
(November 2006); doi:10.1038/ncb1484
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news and views Working out coupled monoubiquitination
Kaisa Haglund & Harald Stenmark Nature Cell Biology8, 1218–1219
(November 2006); doi:10.1038/ncb1106-1218
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article Signals mediated by transforming growth factor-β initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease
Marc Veldhoen, Richard J Hocking, Richard A Flavell & Brigitta Stockinger Nature Immunology7, 1151–1156
(November 2006); doi:10.1038/ni1391
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review The CARMA1 signalosome links the signalling machinery of adaptive and innate immunity in lymphocytes
David J. Rawlings, Karen Sommer and Miguel E. Moreno-García Nature Reviews Immunology6, 799–812
(November 2006); doi:10.1038/nri1944
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review Polycomb silencers control cell fate, development and cancer
Anke Sparmann and Maarten van Lohuizen Nature Reviews Cancer6, 846–856
(November 2006); doi:10.1038/nrc1991
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article Activation of a presynaptic glutamate transporter regulates synaptic transmission through electrical signaling
Margaret Lin Veruki, Svein Harald Mørkve & Espen Hartveit Nature Neuroscience11, 1388–1396
(November 2006); doi:10.1038/nn1793
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news and views Long-distance signaling via presynaptic glutamate transporters
Jacques I Wadiche & Henrique von Gersdorff Nature Neuroscience11, 1352–1353
(November 2006); doi:10.1038/nn1106-1352
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article Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch
Rebecca J Richardson, Jill Dixon, Saimon Malhotra, Matthew J Hardman, Lynnette Knowles, Ray P Boot-Handford, Paul Shore, Alan Whitmarsh & Michael J Dixon Nature Genetics38, 1329–1334
(November 2006); doi:10.1038/ng1894
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