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Research library: browse by date

December 2006

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The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.

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article
Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis
Irene Noguera-Troise, Christopher Daly, Nicholas J. Papadopoulos, Sandra Coetzee, Pat Boland, Nicholas W. Gale, Hsin Chieh Lin, George D. Yancopoulos and Gavin Thurston
Nature 444, 1032–1037
(21 December 2006); doi:10.1038/nature05355
| Summary | Full Text (HTML / PDF) |

letter
Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis
John Ridgway, Gu Zhang, Yan Wu, Scott Stawicki, Wei-Ching Liang, Yvan Chanthery, Joe Kowalski, Ryan J. Watts, Christopher Callahan, Ian Kasman, Mallika Singh, May Chien, Christine Tan, Jo-Anne S. Hongo, Fred de Sauvage, Greg Plowman and Minhong Yan
Nature 444, 1083–1087
(21 December 2006); doi:10.1038/nature05313
| First Paragraph | Full Text (HTML / PDF) |

article
A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis
Laura J. Niedernhofer, George A. Garinis, Anja Raams, Astrid S. Lalai, Andria Rasile Robinson, Esther Appeldoorn, Hanny Odijk, Roos Oostendorp, Anwaar Ahmad, Wibeke van Leeuwen, Arjan F. Theil, Wim Vermeulen, Gijsbertus T. J. van der Horst, Peter Meinecke, Wim J. Kleijer, Jan Vijg, Nicolaas G. J. Jaspers and Jan H. J. Hoeijmakers
Nature 444, 1038–1043
(21 December 2006); doi:10.1038/nature05456
| Summary | Full Text (HTML / PDF) |

letter
Early events in the thymus affect the balance of effector and regulatory T cells
Daniel J. Pennington, Bruno Silva-Santos, Tobias Silberzahn, Mónica Escórcio-Correia, Martin J. Woodward, Scott J. Roberts, Adrian L. Smith, P. Julian Dyson and Adrian C. Hayday
Nature 444, 1073–1077
(21 December 2006); doi:10.1038/nature05368
| First Paragraph | Full Text (HTML / PDF) |

letter
Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity
Rongsheng Jin, Andreas Rummel, Thomas Binz and Axel T. Brunger
Nature 444, 1092–1095
(21 December 2006); doi:10.1038/nature05387
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letter
Structural basis of cell surface receptor recognition by botulinum neurotoxin B
Qing Chai, Joseph W. Arndt, Min Dong, William H. Tepp, Eric A. Johnson, Edwin R. Chapman and Raymond C. Stevens
Nature 444, 1096–1100
(21 December 2006); doi:10.1038/nature05411
| First Paragraph | Full Text (HTML / PDF) |

article
Tyrosine phosphorylation controls PCNA function through protein stability
Shao-Chun Wang, Yusuke Nakajima, Yung-Luen Yu, Weiya Xia, Chun-Te Chen, Cheng-Chieh Yang, Eric W. McIntush, Long-Yuan Li, David H. Hawke, Ryuji Kobayashi & Mien-Chie Hung
Nature Cell Biology 8, 1359–1368
(December 2006); doi:10.1038/ncb1501
| Summary | Full Text (HTML / PDF) |

letter
Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination
Lucia Di Marcotullio, Elisabetta Ferretti, Azzura Greco, Enrico De Smaele, Agnese Po, Maria Anna Sico, Maurizio Alimandi, Giuseppe Giannini, Marella Maroder, Isabella Screpanti & Alberto Gulino
Nature Cell Biology 8, 1415–1423
(December 2006); doi:10.1038/ncb1510
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letter
SUMO-specific protease SUSP4 positively regulates p53 by promoting Mdm2 self-ubiquitination
Moon Hee Lee, Sung Won Lee, Eun Joo Lee, Soo Joon Choi, Sung Soo Chung, Jae Il Lee, Joong Myung Cho, Jae Hong Seol, Sung Hee Baek, Keun Il Kim, Tomoki Chiba, Keiji Tanaka, Ok Sun Bang & Chin Ha Chung
Nature Cell Biology 8, 1424–1431
(December 2006); doi:10.1038/ncb1512
| First Paragraph | Full Text (HTML / PDF) |

review
Membrane-protein topology
Gunnar von Heijne
Nature Reviews Molecular Cell Biology 7, 909–918
(December 2006); doi:10.1038/nrm2063
| Summary | Full Text (HTML / PDF) |

review
Tuning inflammation and immunity by chemokine sequestration: decoys and more
Alberto Mantovani, Raffaella Bonecchi and Massimo Locati
Nature Reviews Immunology 7, 907–918
(December 2006); doi:10.1038/nri1964
| Summary | Full Text (HTML / PDF) |

letter
Regulation of osteoclast differentiation and function by the CaMK-CREB pathway
Kojiro Sato, Ayako Suematsu, Tomoki Nakashima, Sayaka Takemoto-Kimura, Kazuhiro Aoki, Yasuyuki Morishita, Hiroshi Asahara, Keiichi Ohya, Akira Yamaguchi, Toshiyuki Takai, Tatsuhiko Kodama, Talal A Chatila, Haruhiko Bito & Hiroshi Takayanagi
Nature Medicine 12, 1410–1416
(December 2006); doi:10.1038/nm1515
| First Paragraph | Full Text (HTML / PDF) |

letter
v-ATPase V0 subunit d2-deficient mice exhibit impaired osteoclast fusion and increased bone formation
Seoung-Hoon Lee, Jaerang Rho, Daewon Jeong, Jai-Yoon Sul, Taesoo Kim, Nacksung Kim, Ju-Seob Kang, Takeshi Miyamoto, Toshio Suda, Sun-Kyeong Lee, Robert J Pignolo, Boguslawa Koczon-Jaremko, Joseph Lorenzo & Yongwon Choi
Nature Medicine 12, 1403–1409
(December 2006); doi:10.1038/nm1514
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letter
A chromatin-mediated mechanism for specification of conditional transcription factor targets
Michael J Buck & Jason D Lieb
Nature Genetics 38, 1446–1451
(December 2006); doi:10.1038/ng1917
| First Paragraph | Full Text (HTML / PDF) |

review
How flies get their size: genetics meets physiology
Bruce A. Edgar
Nature Reviews Genetics 7, 907–916
(December 2006); doi:10.1038/nrg1989
| Summary | Full Text (HTML / PDF) |

letter
Bace1 modulates myelination in the central and peripheral nervous system
Xiangyou Hu, Caitlin W Hicks, Wanxia He, Philip Wong, Wendy B Macklin, Bruce D Trapp & Riqiang Yan
Nature Neuroscience 9, 1520–1525
(December 2006); doi:10.1038/nn1797
| First Paragraph | Full Text (HTML / PDF) |

review
High-conductance potassium channels of the SLO family
Lawrence Salkoff, Alice Butler, Gonzalo Ferreira, Celia Santi and Aguan Wei
Nature Reviews Neuroscience 7, 1520–1525
(December 2006); doi:10.1038/nrn1992
| Summary | Full Text (HTML / PDF) |

review
Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies
Robert E W Hancock & Hans-Georg Sahl
Nature Biotechnology 24, 1551–1557
(December 2006); doi:10.1038/nbt1267
| Summary | Full Text (HTML / PDF) |

news and analysis
Panitumumab
Leonard Saltz, Chris Easley and Peter Kirkpatrick
Nature Reviews Drug Discovery 5, 987–988
(December 2006); doi:10.1038/nrd2204
| Summary | Full Text (HTML / PDF) |

review
Targeting the Hedgehog pathway in cancer
Lee L. Rubin and Frederic J. de Sauvage
Nature Reviews Drug Discovery 5, 1026–1033
(December 2006); doi:10.1038/nrd2086
| Summary | Full Text (HTML / PDF) |

news and views
Of Fat flies and Hippos, or the magic of animal size
Fernando Casares, Carlos M Luque & Maria J Tavares
Nature Structural & Molecular Biology 13, 1051–1053
(December 2006); doi:10.1038/nsmb1206-1051
| Summary | Full Text (HTML / PDF) |

article
Large movement in the C terminus of CLC-0 chloride channel during slow gating
Ekaterina A Bykova, Xiao-Dong Zhang, Tsung-Yu Chen & Jie Zheng
Nature Structural & Molecular Biology 13, 1115–1119
(December 2006); doi:10.1038/nsmb1176
| Summary | Full Text (HTML / PDF) |

article
Conformational restriction blocks glutamate receptor desensitization
Matthew C Weston, Peter Schuck, Alokesh Ghosal, Christian Rosenmund & Mark L Mayer
Nature Structural & Molecular Biology 13, 1120–1127
(December 2006); doi:10.1038/nsmb1178
| Summary | Full Text (HTML / PDF) |

article
CDK1 and calcineurin regulate Maskin association with eIF4E and translational control of cell cycle progression
Quiping Cao, Jong Heon Kim & Joel D Richter
Nature Structural & Molecular Biology 13, 1128–1134
(December 2006); doi:10.1038/nsmb1169
| Summary | Full Text (HTML / PDF) |

article
Monitoring regulated protein-protein interactions using split TEV
Michael C Wehr, Rico Laage, Ulrike Bolz, Tobias M Fischer, Sylvia Grünewald, Sigrid Scheek, Alfred Bach, Klaus-Armin Nave & Moritz J Rossner
Nature Methods 3, 1128–1134
(December 2006); doi:10.1038/nmeth967
| Summary | Full Text (HTML / PDF) |

news and views
Complementary methods for studies of protein interactions in living cells
Tom K Kerppola
Nature Methods 3, 969–971
(December 2006); doi:10.1038/nmeth1206-969
| Summary | Full Text (HTML / PDF) |

article
Two-chamber AFM: probing membrane proteins separating two aqueous compartments
Rui Pedro Gonçalves, Guillaume Agnus, Pierre Sens, Christine Houssin, Bernard Bartenlian & Simon Scheuring
Nature Methods 3, 1007–1012
(December 2006); doi:10.1038/nmeth965
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article
Atomic force microscopy of membrane proteins separating two aqueous compartments
Yves F Dufrêne
Nature Methods 3, 973–975
(December 2006); doi:10.1038/nmeth1206-973
| Summary | Full Text (HTML / PDF) |

article
An efficient tandem affinity purification procedure for interaction proteomics in mammalian cells
Tilmann Bürckstümmer, Keiryn L Bennett, Adrijana Preradovic, Gregor Schütze, Oliver Hantschel, Giulio Superti-Furga & Angela Bauch
Nature Methods 3, 1013–1019
(December 2006); doi:10.1038/nmeth968
| Summary | Full Text (HTML / PDF) |

article
An SCN9A channelopathy causes congenital inability to experience pain
James J. Cox, Frank Reimann, Adeline K. Nicholas, Gemma Thornton, Emma Roberts, Kelly Springell, Gulshan Karbani, Hussain Jafri, Jovaria Mannan, Yasmin Raashid, Lihadh Al-Gazali, Henan Hamamy, Enza Maria Valente, Shaun Gorman, Richard Williams, Duncan P. McHale, John N. Wood, Fiona M. Gribble and C. Geoffrey Woods
Nature 444, 894–898
(14 December 2006); doi:10.1038/nature05413
| Summary | Full Text (HTML / PDF) |

news and views
Neurobiology: A channel sets the gain on pain
Stephen G. Waxman
Nature 444, 831–832
(14 December 2006); doi:10.1038/444831a
| Summary | Full Text (HTML / PDF) |

letter
Inhibition of cytohesins by SecinH3 leads to hepatic insulin resistance
Markus Hafner, Anton Schmitz, Imke Grüne, Seergazhi G. Srivatsan, Bianca Paul, Waldemar Kolanus, Thomas Quast, Elisabeth Kremmer, Inga Bauer and Michael Famulok
Nature 444, 941–944
(14 December 2006); doi:10.1038/nature05415
| First Paragraph | Full Text (HTML / PDF) |

letter
The cytohesin Steppke is essential for insulin signalling in Drosophila
Bernhard Fuss, Thomas Becker, Ingo Zinke and Michael Hoch
Nature 444, 945–948
(14 December 2006); doi:10.1038/nature05412
| First Paragraph | Full Text (HTML / PDF) |

news and views
Diabetes: Kicking off the insulin cascade
Catherine Jackson
Nature 444, 833–834
(14 December 2006); doi:10.1038/444833a
| Summary | Full Text (HTML / PDF) |

letter
Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitine
Nikolay O. Bukanov, Laurie A. Smith, Katherine W. Klinger, Steven R. Ledbetter and Oxana Ibraghimov-Beskrovnaya
Nature 444, 949–952
(14 December 2006); doi:10.1038/nature05348
| First Paragraph | Full Text (HTML / PDF) |

article
Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies
Hyungjin Kim, Mubina Rafiuddin-Shah, Ho-Chou Tu, John R. Jeffers, Gerard P. Zambetti, James J.-D. Hsieh & Emily H.-Y. Cheng
Nature Cell Biology 8, 1348–1358
(December 2006); doi:10.1038/ncb1499
| Summary | Full Text (HTML / PDF) |

news and views
Upgrading the BCL-2 Network
Heidi L. Galonek & J. Marie Hardwick
Nature Cell Biology 8, 1317–1319
(December 2006); doi:10.1038/ncb1206-1317
| Summary | Full Text (HTML / PDF) |

letter
A Wnt-Axin2-GSK3β cascade regulates Snail1 activity in breast cancer cells
Jong In Yook, Xiao-Yan Li, Ichiro Ota, Casey Hu, Hyun Sil Kim, Nam Hee Kim, So Young Cha, Joo Kyung Ryu, Yoon Jung Choi, Jin Kim, Eric R. Fearon & Stephen J. Weiss
Nature Cell Biology 8, 1398–1406
(December 2006); doi:10.1038/ncb1508
| First Paragraph | Full Text (HTML / PDF) |

article
Fever-range thermal stress promotes lymphocyte trafficking across high endothelial venules via an interleukin 6 trans-signaling mechanism
Qing Chen, Daniel T Fisher, Kristen A Clancy, Jean-Marc M Gauguet, Wan-Chao Wang, Emily Unger, Stefan Rose-John, Ulrich H von Andrian, Heinz Baumann & Sharon S Evans
Nature Immunology 7, 1293–1298
(December 2006); doi:10.1038/ni1406
| Summary | Full Text (HTML / PDF) |

review
Regulating the p53 pathway: in vitro hypotheses, in vivo veritas
Franck Toledo and Geoffrey M. Wahl
Nature Reviews Cancer 6, 906–923
(December 2006); doi:10.1038/nrc2012
| Summary | Full Text (HTML / PDF) |

article
A diacylglycerol kinase modulates long-term thermotactic behavioral plasticity in C. elegans
David Biron, Mayumi Shibuya, Christopher Gabel, Sara M Wasserman, Damon A Clark, Adam Brown, Piali Sengupta & Aravinthan D T Samuel
Nature Neuroscience 9, 1499–1505
(December 2006); doi:10.1038/nn1796
| Summary | Full Text (HTML / PDF) |

article
Dynorphin A activates bradykinin receptors to maintain neuropathic pain
Josephine Lai, Miaw-Chyi Luo, Qingmin Chen, Shouwu Ma, Luis R Gardell, Michael H Ossipov & Frank Porreca
Nature Neuroscience 9, 1534–1540
(December 2006); doi:10.1038/nn1804
| Summary | Full Text (HTML / PDF) |

brief communication
Blue fluorescent proteins with enhanced brightness and photostability from a structurally targeted library
Marco A Mena, Thomas P Treynor, Stephen L Mayo & Patrick S Daugherty
Nature Biotechnology 24, 1569–1571
(December 2006); doi:10.1038/nbt1264
| Summary | Full Text (HTML / PDF) |

opinion
How many drug targets are there?
John P. Overington, Bissan Al-Lazikani and Andrew L. Hopkins
Nature Reviews Drug Discovery 5, 993–996
(December 2006); doi:10.1038/nrd2199
| Summary | Full Text (HTML / PDF) |

article
Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells
Karin Loser, Annette Mehling, Stefanie Loeser, Jenny Apelt, Annegret Kuhn, Stephan Grabbe, Thomas Schwarz, Josef M Penninger & Stefan Beissert
Nature Medicine 12, 1372–1379
(December 2006); doi:10.1038/nm1518
| Summary | Full Text (HTML / PDF) |

news and views
Skin controls immune regulators
Tomoyuki Yamaguchi & Shimon Sakaguchi
Nature Medicine 12, 1358–1359
(December 2006); doi:10.1038/nm1206-1358
| Summary | Full Text (HTML / PDF) |

article
Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling
Mark A. Daniels, Emma Teixeiro, Jason Gill, Barbara Hausmann, Dominique Roubaty, Kaisa Holmberg, Guy Werlen, Georg A. Holländer, Nicholas R. J. Gascoigne and Ed Palmer
Nature 444, 724–729
(7 December 2006); doi:10.1038/nature05269
| Summary | Full Text (HTML / PDF) |

letter
Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells
S. G. M. Piccirillo, B. A. Reynolds, N. Zanetti, G. Lamorte, E. Binda, G. Broggi, H. Brem, A. Olivi, F. Dimeco and A. L. Vescovi
Nature 444, 761–765
(7 December 2006); doi:10.1038/nature05349
| First Paragraph | Full Text (HTML / PDF) |

letter
Klotho converts canonical FGF receptor into a specific receptor for FGF23
Itaru Urakawa, Yuji Yamazaki, Takashi Shimada, Kousuke Iijima, Hisashi Hasegawa, Katsuya Okawa, Toshiro Fujita, Seiji Fukumoto and Takeyoshi Yamashita
Nature 444, 770–774
(7 December 2006); doi:10.1038/nature05315
| First Paragraph | Full Text (HTML / PDF) |

letter
Phospholipids and the origin of cationic gating charges in voltage sensors
Daniel Schmidt, Qiu-Xing Jiang and Roderick MacKinnon
Nature 444, 775–779
(7 December 2006); doi:10.1038/nature05416
| First Paragraph | Full Text (HTML / PDF) |

article
Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells
Jongdae Lee, Ji-Hun Mo, Kyoko Katakura, Irit Alkalay, Adam N. Rucker, Yu-Tsueng Liu, Hyun-Ku Lee, Carol Shen, Gady Cojocaru, Steve Shenouda, Martin Kagnoff, Lars Eckmann, Yinon Ben-Neriah & Eyal Raz
Nature Cell Biology 8, 1327–1336
(December 2006); doi:10.1038/ncb1500
| Summary | Full Text (HTML / PDF) |

letter
Phospholipase Cγ1 negatively regulates growth hormone signalling by forming a ternary complex with Jak2 and protein tyrosine phosphatase-1B
Jang Hyun Choi, Hyeon Soo Kim, Sun-Hee Kim, Yong Ryoul Yang, Yun Soo Bae, Jong-Soo Chang, H. Moo Kwon, Sung Ho Ryu & Pann-Ghill Suh
Nature Cell Biology 8, 1389–1397
(December 2006); doi:10.1038/ncb1509
| First Paragraph | Full Text (HTML / PDF) |

letter
The armadillo protein p0071 regulates Rho signalling during cytokinesis
Annika Wolf, Rene Keil, Oliver Götzl, Andrej Mun, Katrin Schwarze, Marcell Lederer, Stefan Hüttelmaier & Mechthild Hatzfeld
Nature Cell Biology 8, 1432–1440
(December 2006); doi:10.1038/ncb1504
| First Paragraph | Full Text (HTML / PDF) |

review
Powering membrane traffic in endocytosis and recycling
Thierry Soldati and Manfred Schliwa
Nature Reviews Molecular Cell Biology 7, 897–908
(December 2006); doi:10.1038/nrm2060
| Summary | Full Text (HTML / PDF) |

review
Protozoan encounters with Toll-like receptor signalling pathways: implications for host parasitism
Ricardo T. Gazzinelli and Eric Y. Denkers
Nature Reviews Immunology 6, 895–906
(December 2006); doi:10.1038/nri1978
| Summary | Full Text (HTML / PDF) |

letter
Genomic and functional evolution of the Drosophila melanogaster sperm proteome
Steve Dorus, Scott A Busby, Ursula Gerike, Jeffrey Shabanowitz, Donald F Hunt & Timothy L Karr
Nature Genetics 38, 1440–1445
(December 2006); doi:10.1038/ng1915
| First paragraph | Full Text (HTML / PDF) |

review
Genetics of autoimmune diseases — disorders of immune homeostasis
Peter K. Gregersen and Timothy W. Behrens
Nature Reviews Genetics 7, 917–928
(December 2006); doi:10.1038/nrg1944
| Summary | Full Text (HTML / PDF) |

article
The P2Y12 receptor regulates microglial activation by extracellular nucleotides
Sharon E Haynes, Gunther Hollopeter, Guang Yang, Dana Kurpius, Michael E Dailey, Wen-Biao Gan & David Julius
Nature Neuroscience 9, 1512–1519
(December 2006); doi:10.1038/nn1805
| Summary | Full Text (HTML / PDF) |

news and views
Triggering the brain's pathology sensor
Helmut Kettenmann
Nature Neuroscience 9, 1463–1464
(December 2006); doi:10.1038/nn1206-1463
| Summary | Full Text (HTML / PDF) |

review
Mining the Wnt pathway for cancer therapeutics
Nick Barker and Hans Clevers
Nature Reviews Drug Discovery 5, 997–1014
(December 2006); doi:10.1038/nrd2154
| Summary | Full Text (HTML / PDF) |

article
Direct observation of individual endogenous protein complexes in situ by proximity ligation
Ola Söderberg, Mats Gullberg, Malin Jarvius, Karin Ridderstråle, Karl-Johan Leuchowius, Jonas Jarvius, Kenneth Wester, Per Hydbring, Fuad Bahram, Lars-Gunnar Larsson & Ulf Landegren
Nature Methods 3, 995–1000
(December 2006); doi:10.1038/nrd2154
| Summary | Full Text (HTML / PDF) |

news and views
Single protein complex visualization: Seeing is believing
Sam Lievens & Jan Tavernier
Nature Methods 3, 971–972
(December 2006); doi:10.1038/nmeth1206-971
| Summary | Full Text (HTML / PDF) |

article
A rigorous experimental framework for detecting protein oligomerization using bioluminescence resonance energy transfer
John R James, Marta I Oliveira, Alexandre M Carmo, Andrea Iaboni & Simon J Davis
Nature Methods 3, 1001–1006
(December 2006); doi:10.1038/nmeth978
| Summary | Full Text (HTML / PDF) |

news and views
G protein—coupled receptors: too many dimers?
Martin J Lohse
Nature Methods 3, 972–973
(December 2006); doi:10.1038/nmeth1206-972
| Summary | Full Text (HTML / PDF) |

letter
Centriole assembly in Caenorhabditis elegans
Alastair M. Hosie, Megan E. Wilkins, Helena M. A. da Silva and Trevor G. Smart
Nature 444, 619–623
(30 November 2006); doi:10.1038/nature05318
| First Paragraph | Full Text (HTML / PDF) |

letter
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
Jirina Bartkova, Nousin Rezaei, Michalis Liontos, Panagiotis Karakaidos, Dimitris Kletsas, Natalia Issaeva, Leandros-Vassilios F. Vassiliou, Evangelos Kolettas, Katerina Niforou, Vassilis C. Zoumpourlis, Munenori Takaoka, Hiroshi Nakagawa, Frederic Tort, Kasper Fugger, Fredrik Johansson, Maxwell Sehested, Claus L. Andersen, Lars Dyrskjot, Torben Ørntoft, Jiri Lukas, Christos Kittas, Thomas Helleday, Thanos D. Halazonetis, Jiri Bartek and Vassilis G. Gorgoulis
Nature 444, 633–637
(30 November 2006); doi:10.1038/nature05268
| First Paragraph | Full Text (HTML / PDF) |

article
Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex
Andrea Disanza, Sara Mantoani, Maud Hertzog, Silke Gerboth, Emanuela Frittoli, Anika Steffen, Kerstin Berhoerster, Hans-Juergen Kreienkamp, Francesca Milanesi, Pier Paolo Di Fiore, Andrea Ciliberto, Theresia E. B. Stradal & Giorgio Scita
Nature Cell Biology 8, 1337–1347
(December 2006); doi:10.1038/ncb1502
| Summary | Full Text (HTML / PDF) |

letter
Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis
Sachie Hiratsuka, Akira Watanabe, Hiroyuki Aburatani & Yoshiro Maru
Nature Cell Biology 8, 1369–1375
(December 2006); doi:10.1038/ncb1507
| First Paragraph | Full Text (HTML / PDF) |

news and views
S100 chemokines mediate bookmarking of premetastatic niches
Shahin Rafii & David Lyden
Nature Cell Biology 8, 1321–1323
(December 2006); doi:10.1038/ncb1206-1321
| Summary | Full Text (HTML / PDF) |

review
Adipocyte differentiation from the inside out
Evan D. Rosen and Ormond A. MacDougald
Nature Reviews Molecular Cell Biology 7, 885–896
(December 2006); doi:10.1038/nrm2066
| Summary | Full Text (HTML / PDF) |

article
Control of thymocyte development and recombination-activating gene expression by the zinc finger protein Zfp608
Feng Zhang, Lance R Thomas, Eugene M Oltz & Thomas M Aune
Nature Immunology 7, 1309–1316
(December 2006); doi:10.1038/ni1397
| Summary | Full Text (HTML / PDF) |

news and views
Fetal thymocyte development: putting a zinc finger on it?
Andrea C Carpenter & Craig H Bassing
Nature Immunology 7, 1285–1286
(December 2006); doi:10.1038/ni1206-1285
| Summary | Full Text (HTML / PDF) |

article
Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs
Attila Mócsai, Clare L Abram, Zoltán Jakus, Yongmei Hu, Lewis L Lanier & Clifford A Lowell
Nature Immunology 7, 1326–1333
(December 2006); doi:10.1038/ni1407
| Summary | Full Text (HTML / PDF) |

news and views
Integrins and ITAMs: more than just good neighbors
Mark L Kahn & Gary A Koretzky
Nature Immunology 7, 1286–1288
(December 2006); doi:10.1038/ni1206-1286
| Summary | Full Text (HTML / PDF) |

review
Perforin-mediated target-cell death and immune homeostasis
Ilia Voskoboinik, Mark J. Smyth and Joseph A. Trapani
Nature Reviews Immunology 6, 940–952
(December 2006); doi:10.1038/nri1983
| Summary | Full Text (HTML / PDF) |

review
SNAREing immunity: the role of SNAREs in the immune system
Jennifer L. Stow, Anthony P. Manderson and Rachael Z. Murray
Nature Reviews Immunology 6, 919–929
(December 2006); doi:10.1038/nri1980
| Summary | Full Text (HTML / PDF) |

review
The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis
Daniel W. Nebert and Timothy P. Dalton
Nature Reviews Cancer 6, 947–960
(December 2006); doi:10.1038/nrc2015
| Summary | Full Text (HTML / PDF) |

article
SYD-2 Liprin-alpha organizes presynaptic active zone formation through ELKS
Ya Dai, Hidenori Taru, Scott L Deken, Brock Grill, Brian Ackley, Michael L Nonet & Yishi Jin
Nature Neuroscience 9, 1479–1487
(December 2006); doi:10.1038/nn1808
| Summary | Full Text (HTML / PDF) |

review
Axonal conduction and injury in multiple sclerosis: the role of sodium channels
Stephen G. Waxman
Nature Reviews Neuroscience 7, 932–941
(December 2006); doi:10.1038/nrn2023
| Summary | Full Text (HTML / PDF) |

letter
BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing
Kunikazu Tsuji, Amitabha Bandyopadhyay, Brian D Harfe, Karen Cox, Sanjeev Kakar, Louis Gerstenfeld, Thomas Einhorn, Clifford J Tabin & Vicki Rosen
Nature Genetics 38, 1424–1429
(December 2006); doi:10.1038/ng1916
| First Paragraph | Full Text (HTML / PDF) |

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