The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.
Click here for free access to the 'Featured Articles' section, with new articles every week.
article Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter
Olga Boudker, Renae M. Ryan, Dinesh Yernool, Keiko Shimamoto and Eric Gouaux Nature445, 387–393
(25 January 2007); doi:10.1038/nature05455
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article Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity
Danny T. Huang, Harold W. Hunt, Min Zhuang, Melanie D. Ohi, James M. Holton and Brenda A. Schulman Nature445, 394–398
(25 January 2007); doi:10.1038/nature05490
| Summary | Full Text (HTML / PDF) |
letter 'Infotaxis' as a strategy for searching without gradients
Massimo Vergassola, Emmanuel Villermaux and Boris I. Shraiman Nature445, 406–409
(25 January 2007); doi:10.1038/nature05464
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letter Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin
Fan Pan, Luo Sun, David B. Kardian, Katharine A. Whartenby, Drew M. Pardoll and Jun O. Liu Nature445, 433–436
(25 January 2007); doi:10.1038/nature05476
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letter Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3
Natalia V. Sergina, Megan Rausch, Donghui Wang, Jimmy Blair, Byron Hann, Kevan M. Shokat and Mark M. Moasser Nature445, 437–441
(25 January 2007); doi:10.1038/nature05474
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letter Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2
Daniel W. Young, Mohammad Q. Hassan, Jitesh Pratap, Mario Galindo, Sayyed K. Zaidi, Suk-hee Lee, Xiaoqing Yang, Ronglin Xie, Amjad Javed, Jean M. Underwood, Paul Furcinitti, Anthony N. Imbalzano, Sheldon Penman, Jeffrey A. Nickerson, Martin A. Montecino, Jane B. Lian, Janet L. Stein, Andre J. van Wijnen and Gary S. Stein Nature445, 442–446
(25 January 2007); doi:10.1038/nature05473
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letter Cdk and APC activities limit the spindle-stabilizing function of Fin1 to anaphase
Erika L. Woodbury & David O. Morgan Nature Cell Biology9, 106–112
(January 2007); doi:10.1038/ncb1523
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review The WASP-WAVE protein network: connecting the membrane to the cytoskeleton
Tadaomi Takenawa and Shiro Suetsugu Nature Reviews Molecular Cell Biology8, 37–48
(January 2007); doi:10.1038/nrm2069
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review The kinases aurora B and mTOR regulate the G1-S cell cycle progression of T lymphocytes
Jianxun Song, Shahram Salek-Ardakani, Takanori So & Michael Croft Nature Immunology8, 64–73
(January 2007); doi:10.1038/ni1413
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article NF-κB in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF
Bae Keun Park, Honglai Zhang, Qinghua Zeng, Jinlu Dai, Evan T Keller, Thomas Giordano, Keni Gu, Veena Shah, Lei Pei, Richard J Zarbo, Laurie McCauley, Songtao Shi, Shaoqiong Chen & Cun-Yu Wang Nature Medicine13, 62–69
(January 2007); doi:10.1038/nm1519
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article Calreticulin exposure dictates the immunogenicity of cancer cell death
Michel Obeid, Antoine Tesniere, François Ghiringhelli, Gian Maria Fimia, Lionel Apetoh, Jean-Luc Perfettini, Maria Castedo, Grégoire Mignot, Theoharis Panaretakis, Noelia Casares, Didier Métivier, Nathanael Larochette, Peter van Endert, Fabiola Ciccosanti, Mauro Piacentini, Laurence Zitvogel & Guido Kroemer Nature Medicine13, 54–61
(January 2007); doi:10.1038/nm1523
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perspective The Connectivity Map: a new tool for biomedical research
Justin Lamb Nature Reviews Cancer7, 54–60
(January 2007); doi:10.1038/nrc2044
| Summary | Full Text (HTML / PDF) |
article PDGF signaling specificity is mediated through multiple immediate early genes
Jennifer Schmahl, Christopher S Raymond & Philippe Soriano Nature Genetics39, 52–60
(January 2007); doi:10.1038/ng1922
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article Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism
Wing-Yu Fu, Yu Chen, Mustafa Sahin, Xiao-Su Zhao, Lei Shi, Jay B Bikoff, Kwok-On Lai, Wing-Ho Yung, Amy K Y Fu, Michael E Greenberg & Nancy Y Ip Nature Neuroscience10, 67–76
(January 2007); doi:10.1038/nn1811
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article Isolation of amniotic stem cell lines with potential for therapy
Paolo De Coppi, Georg Bartsch Jr, M Minhaj Siddiqui, Tao Xu, Cesar C Santos, Laura Perin, Gustavo Mostoslavsky, Angéline C Serre, Evan Y Snyder, James J Yoo, Mark E Furth, Shay Soker & Anthony Atala Nature Biotechnology25, 100–106
(January 2007); doi:10.1038/nbt1274
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brief communication Fast manipulation of cellular cAMP level by light in vivo
Saskia Schröder-Lang, Martin Schwärzel, Reinhard Seifert, Timo Strünker, Suneel Kateriya, Jens Looser, Masakatsu Watanabe, U Benjamin Kaupp, Peter Hegemann & Georg Nagel Nature Methods4, 39–42
(January 2007); doi:10.1038/nmeth975
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article Efficient T-cell receptor signaling requires a high-affinity interaction between the Gads C-SH3 domain and the SLP-76 RxxK motif
Bruce T Seet, Donna M Berry, Jonathan S Maltzman, Jacob Shabason, Monica Raina, Gary A Koretzky, C Jane McGlade and Tony Pawson The EMBO JournalAOP,
(18 January 2007); doi:10.1038/sj.emboj.7601535
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letter Sonic hedgehog function in chondrichthyan fins and the evolution of appendage patterning
Randall D. Dahn, Marcus C. Davis, William N. Pappano and Neil H. Shubin Nature445, 311–314
(18 January 2007); doi:10.1038/nature05436
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article Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast
Philip Zegerman and John F. X. Diffley Nature445, 281–285
(18 January 2007); doi:10.1038/nature05432
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article Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1
Miki Nishio, Ken-ichi Watanabe, Junko Sasaki, Choji Taya, Shunsuke Takasuga, Ryota Iizuka, Tamas Balla, Masakazu Yamazaki, Hiroshi Watanabe, Reietsu Itoh, Shoko Kuroda, Yasuo Horie, Irmgard Förster, Tak W. Mak, Hiromichi Yonekawa, Josef M. Penninger, Yasunori Kanaho, Akira Suzuki & Takehiko Sasaki Nature Cell Biology9, 36–44
(January 2007); doi:10.1038/ncb1515
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news and views Leading-edge research: PtdIns(3,4,5)P3 and directed migration
Jonathan Franca-Koh, Yoichiro Kamimura & Peter N. Devreotes Nature Cell Biology9, 15–17
(January 2007); doi:10.1038/ncb0107-15
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letter PI(3)Kγ has an important context-dependent role in neutrophil chemokinesis
G. John Ferguson, Laura Milne, Suhasini Kulkarni, Takehiko Sasaki, Simon Walker, Simon Andrews, Tom Crabbe, Peter Finan, Gareth Jones, Shaun Jackson, Montserrat Camps, Christian Rommel, Matthias Wymann, Emilio Hirsch, Phillip Hawkins & Len Stephens Nature Cell Biology9, 86–91
(January 2007); doi:10.1038/ncb1517
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review Illuminating the silence: understanding the structure and function of small RNAs
Tariq M. Rana Nature Reviews Molecular Cell Biology8, 23–36
(January 2007); doi:10.1038/nrm2085
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article Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production
Ewen Gallagher, Thomas Enzler, Atsushi Matsuzawa, Amy Anzelon-Mills, Dennis Otero, Ryan Holzer, Edith Janssen, Min Gao & Michael Karin Nature Immunology8, 57–63
(January 2007); doi:10.1038/ni1421
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review T-cell regulation: with complements from innate immunity
Claudia Kemper and John P. Atkinson Nature Reviews Immunology7, 9–18
(January 2007); doi:10.1038/nri1994
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article Targeting the NF-κB signaling pathway in Notch1-induced T-cell leukemia
Tomas Vilimas, Joaquina Mascarenhas, Teresa Palomero, Malay Mandal, Silvia Buonamici, Fanyong Meng, Benjamín Thompson, Christina Spaulding, Sami Macaroun, Maria-Luisa Alegre, Barbara L Kee, Adolfo Ferrando, Lucio Miele & Iannis Aifantis Nature Medicine13, 70–77
(January 2007); doi:10.1038/nm1524
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opinion Chemoprevention of breast cancer with selective oestrogen-receptor modulators
V. Craig Jordan Nature Reviews Cancer7, 46–53
(January 2007); doi:10.1038/nrc2048
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letter Wnt-β-catenin signaling initiates taste papilla development
Fei Liu, Shoba Thirumangalathu, Natalie M Gallant, Steven H Yang, Cristi L Stoick-Cooper, Seshamma T Reddy, Thomas Andl, Makoto M Taketo, Andrzej A Dlugosz, Randall T Moon, Linda A Barlow & Sarah E Millar Nature Genetics39, 106–112
(January 2007); doi:10.1038/ng1932
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article PKC-1 regulates secretion of neuropeptides
Derek Sieburth, Jon M Madison & Joshua M Kaplan Nature Neuroscience10, 49–57
(January 2007); doi:10.1038/nn1810
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review How to make a mesodiencephalic dopaminergic neuron
Marten P. Smidt and J. Peter H. Burbach Nature Reviews Neuroscience8, 21–32
(January 2007); doi:10.1038/nrn2039
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article Absolute protein expression profiling estimates the relative contributions of transcriptional and translational regulation
Peng Lu, Christine Vogel, Rong Wang, Xin Yao & Edward M Marcotte Nature Biotechnology25, 117–124
(January 2007); doi:10.1038/nbt1270
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letter Computational prediction of proteotypic peptides for quantitative proteomics
Parag Mallick, Markus Schirle, Sharon S Chen, Mark R Flory, Hookeun Lee, Daniel Martin, Jeffrey Ranish, Brian Raught, Robert Schmitt, Thilo Werner, Bernhard Kuster & Ruedi Aebersold Nature Biotechnology25, 125–131
(January 2007); doi:10.1038/nbt1275
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news and views Peptides you can count on
John JM Bergeron & Michael Hallett Nature Biotechnology25, 61–62
(January 2007); doi:10.1038/nbt0107-61
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brief communication Sensitive and specific method for detecting G protein-coupled receptor mRNAs
Arne Hansen, Yidong Chen, Jason M Inman, Quang N Phan, Zhi-Qing Qi, Charlie C Xiang, Miklos Palkovits, Natasha Cherman, Sergei A Kuznetsov, Pamela G Robey, Eva Mezey & Michael J Brownstein Nature Methods4, 35–37
(January 2007); doi:10.1038/nmeth977
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article Imaging cellular network dynamics in three dimensions using fast 3D laser scanning
Werner Göbel, Björn M Kampa & Fritjof Helmchen Nature Methods4, 73–79
(January 2007); doi:10.1038/nmeth989
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article Genome-wide atlas of gene expression in the adult mouse brain
Ed S. Lein et al. Nature445, 168–176
(11 January 2007); doi:10.1038/nature05453
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letter The nuclear receptor LXR is a glucose sensor
Nico Mitro, Puiying A. Mak, Leo Vargas, Cristina Godio, Eric Hampton, Valentina Molteni, Andreas Kreusch and Enrique Saez Nature445, 219–223
(11 January 2007); doi:10.1038/nature05449
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letter PGC7/Stella protects against DNA demethylation in early embryogenesis
Toshinobu Nakamura, Yoshikazu Arai, Hiroki Umehara, Masaaki Masuhara, Tohru Kimura, Hisaaki Taniguchi, Toshihiro Sekimoto, Masahito Ikawa, Yoshihiro Yoneda, Masaru Okabe, Satoshi Tanaka, Kunio Shiota & Toru Nakano Nature Cell Biology9, 64–71
(January 2007); doi:10.1038/ncb1519
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letter Dynein is required for receptor sorting and the morphogenesis of early endosomes
Owen J. Driskell, Aleksandr Mironov, Victoria J. Allan & Philip G. Woodman Nature Cell Biology9, 113–120
(January 2007); doi:10.1038/ncb1525
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review Palmitoylation: policing protein stability and traffic
Maurine E. Linder and Robert J. Deschenes Nature Reviews Molecular Cell Biology8, 74–84
(January 2007); doi:10.1038/nrm2084
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article An injected bacterial effector targets chromatin access for transcription factor NF-κB to alter transcription of host genes involved in immune responses
Laurence Arbibe, Dong Wook Kim, Eric Batsche, Thierry Pedron, Bogdan Mateescu, Christian Muchardt, Claude Parsot & Philippe J Sansonetti Nature Immunology8, 47–56
(January 2007); doi:10.1038/ni1423
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article Hematopoietic progenitor kinase 1 negatively regulates T cell receptor signaling and T cell-mediated immune responses
Jr-Wen Shui, Jonathan S Boomer, Jin Han, Jun Xu, Gregory A Dement, Guisheng Zhou & Tse-Hua Tan Nature Immunology8, 84–91
(January 2007); doi:10.1038/ni1416
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review Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment
Hua Yu, Marcin Kortylewski and Drew Pardoll Nature Reviews Immunology7, 41–51
(January 2007); doi:10.1038/nri1995
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review Cancer phenomics: RET and PTEN as illustrative models
Kevin M. Zbuk and Charis Eng Nature Reviews Cancer7, 35–45
(January 2007); doi:10.1038/nrc2037
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letter A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice
Naoko Shima, Ana Alcaraz, Ivan Liachko, Tavanna R Buske, Catherine A Andrews, Robert J Munroe, Suzanne A Hartford, Bik K Tye & John C Schiment Nature Genetics39, 93–98
(January 2007); doi:10.1038/ng1936
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news and views Chaotic license for genetic instability and cancer
Anindya Dutta Nature Genetics39, 10–11
(January 2007); doi:10.1038/ng0107-10
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article IRS2-Akt pathway in midbrain dopamine neurons regulates behavioral and cellular responses to opiates
Scott J Russo, Carlos A Bolanos, David E Theobald, Nathan A DeCarolis, William Renthal, Arvind Kumar, Catharine A Winstanley, Nora E Renthal, Matthew D Wiley, David W Self, David S Russell, Rachael L Neve, Amelia J Eisch & Eric J Nestler Nature Neuroscience10, 93–99
(January 2007); doi:10.1038/nn1812
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news and views Tolerance to opiate reward: role of midbrain IRS2-Akt pathway
Brandon K Harvey, Bruce T Hope & Yavin Shaham Nature Neuroscience10, 9–10
(January 2007); doi:10.1038/nn0107-9
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letter Forward chemical genetic approach identifies new role for GAPDH in insulin signaling
Jaeki Min, Yun Kyung Kim, Patricia G Cipriani, Mira Kang, Sonya M Khersonsky, Daniel P Walsh, Ji-Young Lee, Sherry Niessen, John R Yates, III, Kristin Gunsalus, Fabio Piano and Young-Tae Chang Nature Chemical Biology3, 55–59
(January 2007); doi:10.1038/nchembio833
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letter Post-translational enzyme activation in an animal via optimized conditional protein splicing
Edmund C Schwartz, Lino Saez, Michael W Young and Tom W Muir Nature Chemical Biology3, 50–54
(January 2007); doi:10.1038/nchembio832
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news and views Shining a light on protein expression in living organisms
Francine B Perler Nature Chemical Biology3, 17–18
(January 2007); doi:10.1038/nchembio0107-17
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letter Two chemosensory receptors together mediate carbon dioxide detection in Drosophila
Walton D. Jones, Pelin Cayirlioglu, Ilona Grunwald Kadow and Leslie B. Vosshall Nature445, 86–90
(4 January 2007); doi:10.1038/nature05466
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news and views Neurobiology: Scent secrets of insects
Rachel I. Wilson Nature445, 30–31
(4 January 2007); doi:10.1038/445030a
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article Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme
Uhn Soo Cho and Wenqing Xu Nature445, 53–57
(4 January 2007); doi:10.1038/nature05351
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letter A systems biology analysis of the Drosophila phagosome
L. M. Stuart, J. Boulais, G. M. Charriere, E. J. Hennessy, S. Brunet, I. Jutras, G. Goyette, C. Rondeau, S. Letarte, H. Huang, P. Ye, F. Morales, C. Kocks, J. S. Bader, M. Desjardins and R. A. B. Ezekowitz Nature445, 95–101
(4 January 2007); doi:10.1038/nature05380
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letter Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1
Jean-Antoine Ribeil, Yael Zermati, Julie Vandekerckhove, Severine Cathelin, Joelle Kersual, Michaël Dussiot, Séverine Coulon, Ivan Cruz Moura, Ann Zeuner, Thomas Kirkegaard-Sørensen, Bruno Varet, Eric Solary, Carmen Garrido and Olivier Hermine Nature445, 102–105
(4 January 2007); doi:10.1038/nature05378
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letter A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
Catherine A. O'Brien, Aaron Pollett, Steven Gallinger and John E. Dick Nature445, 106–110
(4 January 2007); doi:10.1038/nature05372
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letter Identification and expansion of human colon-cancer-initiating cells
Lucia Ricci-Vitiani, Dario G. Lombardi, Emanuela Pilozzi, Mauro Biffoni, Matilde Todaro, Cesare Peschle and Ruggero De Maria Nature445, 111–115
(4 January 2007); doi:10.1038/nature05384
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letter A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family
Nicolas Bocquet, Lia Prado de Carvalho, Jean Cartaud, Jacques Neyton, Chantal Le Poupon, Antoine Taly, Thomas Grutter, Jean-Pierre Changeux and Pierre-Jean Corringer Nature445, 116–119
(4 January 2007); doi:10.1038/nature05371
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article Functional interaction between PML and SATB1 regulates chromatin-loop architecture and transcription of the MHC class I locus
Pavan Kumar P., Oliver Bischof, Prabhat Kumar Purbey, Dimple Notani, Henning Urlaub, Anne Dejean & Sanjeev Galande Nature Cell Biology9, 45–56
(January 2007); doi:10.1038/ncb1516
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letter Sharp boundaries of Dpp signalling trigger local cell death required for Drosophila leg morphogenesis
Cristina Manjón, Ernesto Sánchez-Herrero & Magali Suzanne Nature Cell Biology9, 57–63
(January 2007); doi:10.1038/ncb1518
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news and views Sculpting a fly leg: BMP boundaries and cell death
Marco Milán Nature Cell Biology9, 17–18
(January 2007); doi:10.1038/ncb0107-17
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review Integrating cell-signalling pathways with NF-κB and IKK function
Neil D. Perkins Nature Reviews Molecular Cell Biology8, 49–62
(January 2007); doi:10.1038/nrm2083
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article Dectin-1 is required for β-glucan recognition and control of fungal infection
Philip R Taylor, S Vicky Tsoni, Janet A Willment, Kevin M Dennehy, Marcela Rosas, Helen Findon, Ken Haynes, Chad Steele, Marina Botto, Siamon Gordon & Gordon D Brown Nature Immunology8, 31–38
(January 2007); doi:10.1038/ni1408
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article Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans
Shinobu Saijo, Noriyuki Fujikado, Takahisa Furuta, Soo-hyun Chung, Hayato Kotaki, Keisuke Seki, Katsuko Sudo, Shizuo Akira, Yoshiyuki Adachi, Naohito Ohno, Takeshi Kinjo, Kiwamu Nakamura, Kazuyoshi Kawakami & Yoichiro Iwakura Nature Immunology8, 39–46
(January 2007); doi:10.1038/ni1425
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news and views DEteCTINg fungal pathogens
Catherine Dostert & Jürg Tschopp Nature Immunology8, 17–18
(January 2007); doi:10.1038/ni0107-17
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review Notch signalling during peripheral T-cell activation and differentiation
Barbara A. Osborne and Lisa M. Minter Nature Reviews Immunology7, 64–75
(January 2007); doi:10.1038/nri1998
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review Computational prediction of cancer-gene function
Pingzhao Hu, Gary Bader, Dennis A. Wigle and Andrew Emili Nature Reviews Cancer7, 23–34
(January 2007); doi:10.1038/nrc2036
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letter Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation
Aaheli Roy Choudhury, Zhenyu Ju, Meta W Djojosubroto, Andrea Schienke, Andre Lechel, Sonja Schaetzlein, Hong Jiang, Anna Stepczynska, Chunfang Wang, Jan Buer, Han-Woong Lee, Thomas von Zglinicki, Arnold Ganser, Peter Schirmacher, Hiromitsu Nakauchi & K Lenhard Rudolph Nature Genetics39, 99–105
(January 2007); doi:10.1038/ng1937
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news and views Telomeres, p21 and the cancer-aging hypothesis
Jessica F Bell & Norman E Sharpless Nature Genetics39, 11–12
(January 2007); doi:10.1038/ng0107-11
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review The mouse as a model for human biology: a resource guide for complex trait analysis
Luanne L. Peters, Raymond F. Robledo, Carol J. Bult, Gary A. Churchill, Beverly J. Paigen and Karen L. Svenso Nature Reviews Genetics8, 58–69
(January 2007); doi:10.1038/nrg2025
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article Essential function of HIPK2 in TGFβ-dependent survival of midbrain dopamine neurons
Jiasheng Zhang, Vanee Pho, Stephen J Bonasera, Jed Holzmann, Amy T Tang, Joanna Hellmuth, Siuwah Tang, Patricia H Janak, Laurence H Tecott & Eric J Huang Nature Neuroscience10, 77–86
(January 2007); doi:10.1038/nn1816
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news and views How dopamine neurons survive
Annette Markus Nature Neuroscience10, 12
(January 2007); doi:10.1038/nn0107-12
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review Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
Michelle L. Block, Luigi Zecca and Jau-Shyong Hong Nature Reviews Neuroscience8, 57–69
(January 2007); doi:10.1038/nrn2038
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article CDK1 and calcineurin regulate Maskin association with eIF4E and translational control of cell cycle progression
Quiping Cao, Jong Heon Kim & Joel D Richter Nature Structural & Molecular Biology13, 1128–1134
(January 2007); doi:10.1038/nsmb1169
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brief communication Disentangling conformational states of macromolecules in 3D-EM through likelihood optimization
Sjors H W Scheres, Haixiao Gao, Mikel Valle, Gabor T Herman, Paul P B Eggermont, Joachim Frank & Jose-Maria Carazo Nature Methods4, 27–29
(January 2007); doi:10.1038/nmeth992
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