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Research library: browse by date

February 2007

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The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.

Click here for free access to the 'Featured Articles' section, with new articles every week.

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article
A genome-wide association study identifies novel risk loci for type 2 diabetes
Robert Sladek, Ghislain Rocheleau, Johan Rung, Christian Dina, Lishuang Shen, David Serre, Philippe Boutin, Daniel Vincent, Alexandre Belisle, Samy Hadjadj, Beverley Balkau, Barbara Heude, Guillaume Charpentier, Thomas J. Hudson, Alexandre Montpetit, Alexey V. Pshezhetsky, Marc Prentki, Barry I. Posner, David J. Balding, David Meyre, Constantin Polychronakos and Philippe Froguel
Nature 445, 881–885
(22 February 2007); doi:10.1038/nature05616
| Summary | Full Text (HTML / PDF) |

letter
eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans
Popi Syntichaki, Kostoula Troulinaki and Nektarios Tavernarakis
Nature 445, 922–926
(22 February 2007); doi:10.1038/nature05603
| First Paragraph | Full Text (HTML / PDF) |

letter
Foxp3 occupancy and regulation of key target genes during T-cell stimulation
Alexander Marson, Karsten Kretschmer, Garrett M. Frampton, Elizabeth S. Jacobsen, Julia K. Polansky, Kenzie D. MacIsaac, Stuart S. Levine, Ernest Fraenkel, Harald von Boehmer and Richard A. Young
Nature 445, 931–935
(22 February 2007); doi:10.1038/nature05478
| First Paragraph | Full Text (HTML / PDF) |

letter
TRAPPI tethers COPII vesicles by binding the coat subunit Sec23
Huaqing Cai, Sidney Yu, Shekar Menon, Yiying Cai, Darina Lazarova, Chunmei Fu, Karin Reinisch, Jesse C. Hay and Susan Ferro-Novick
Nature 445, 941–944
(22 February 2007); doi:10.1038/nature05527
| First Paragraph | Full Text (HTML / PDF) |

brief communication arising
Bone Metastasis: Can osteoclasts be excluded?
T. John Martin and Gregory R. Mundy
Nature 445, E19
(22 February 2007); doi:10.1038/nature05657
| Summary | Full Text (HTML / PDF) |

brief communication arising
Bone Metastasis: Can osteoclasts be excluded? (Reply)
D. Holstead Jones, Tomoki Nakashima, Otto H. Sanchez, Ivona Kozieradzki, Svetlana V. Komarova, Ildiko Sarosi, Sean Morony, Evelyn Rubin, Renu Sarao, Carlo V. Hojilla, Vukoslav Komnenovic, Young-Yun Kong, Martin Schreiber, S. Jeffrey Dixon, Stephen M. Sims, Rama Khokha, Teiji Wada and Josef M. Penninger
Nature 445, E19
(22 February 2007); doi:10.1038/nature05658
| Summary | Full Text (HTML / PDF) |

article
Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells
Ivana M Djuretic, Ditsa Levanon, Varda Negreanu, Yoram Groner, Anjana Rao & K Mark Ansel
Nature Immunology 8, 145–153
(February 2007); doi:10.1038/ni1424
| Summary | Full Text (HTML / PDF) |

article
B and T lymphocyte attenuator regulates CD8+ T cell–intrinsic homeostasis and memory cell generation
Carsten Krieg, Onur Boyman, Yang-Xin Fu & Jonathan Kaye
Nature Immunology 8, 162–171
(February 2007); doi:10.1038/ni1418
| Summary | Full Text (HTML / PDF) |

review
Interleukin-7 receptor expression: intelligent design
Renata Mazzucchelli and Scott K. Durum
Nature Reviews Immunology 7, 144–154
(February 2007); doi:10.1038/nri2023
| Summary | Full Text (HTML / PDF) |

perspective
Activating and inhibitory functions of DAP12
Isaiah R. Turnbull and Marco Colonna
Nature Reviews Immunology 7, 155–161
(February 2007); doi:10.1038/nri2014
| Summary | Full Text (HTML / PDF) |

article
Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide
Philipp A Lang, Marcus Schenck, Jan P Nicolay, Jan Ulrich Becker, Daniela S Kempe, Adrian Lupescu, Saisudha Koka, Kerstin Eisele, Barbara A Klarl, Herbert Rübben, Kurt W Schmid, Klaus Mann, Sibylle Hildenbrand, Harald Hefter, Stephan M Huber, Thomas Wieder, Andreas Erhardt, Dieter Häussinger, Erich Gulbins & Florian Lang
Nature Medicine 13, 164–170
(February 2007); doi:10.1038/nm1539
| Summary | Full Text (HTML / PDF) |

review
Myelodysplastic syndromes: the complexity of stem-cell diseases
Seth J. Corey, Mark D. Minden, Dwayne L. Barber, Hagop Kantarjian, Jean C. Y. Wang and Aaron D. Schimmer
Nature Reviews Cancer 7, 118–129
(February 2007); doi:10.1038/nrc2047
| Summary | Full Text (HTML / PDF) |

article
PTEN-deficient intestinal stem cells initiate intestinal polyposis
Xi C He, Tong Yin, Justin C Grindley, Qiang Tian, Toshiro Sato, W Andy Tao, Raminarao Dirisina, Kimberly S Porter-Westpfahl, Mark Hembree, Teri Johnson, Leanne M Wiedemann, Terrence A Barrett, Leroy Hood, Hong Wu & Linheng Li
Nature Genetics 39, 189–198
(February 2007); doi:10.1038/ng1928
| Summary | Full Text (HTML / PDF) |

letter
Zebrafish miR-214 modulates Hedgehog signaling to specify muscle cell fate
Alex S Flynt, Nan Li, Elizabeth J Thatcher, Lilianna Solnica-Krezel & James G Patton
Nature Genetics 39, 259–263
(February 2007); doi:10.1038/ng1953
| Summary | Full Text (HTML / PDF) |

letter
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
Jochen Hampe, Andre Franke, Philip Rosenstiel, Andreas Till, Markus Teuber, Klaus Huse, Mario Albrecht, Gabriele Mayr, Francisco M De La Vega, Jason Briggs, Simone Günther, Natalie J Prescott, Clive M Onnie, Robert Häsler, Bence Sipos, Ulrich R Fölsch, Thomas Lengauer, Matthias Platzer, Christopher G Mathew, Michael Krawczak & Stefan Schreiber
Nature Genetics 39, 207–211
(February 2007); doi:10.1038/ng1954
| Summary | Full Text (HTML / PDF) |

letter
A nonsynonymous SNP in PRKCH (protein kinase C η) increases the risk of cerebral infarction
Michiaki Kubo, Jun Hata, Toshiharu Ninomiya, Koichi Matsuda, Koji Yonemoto, Toshiaki Nakano, Tomonaga Matsushita, Keiko Yamazaki, Yozo Ohnishi, Susumu Saito, Takanari Kitazono, Setsuro Ibayashi, Katsuo Sueishi, Mitsuo Iida, Yusuke Nakamura & Yutaka Kiyohara
Nature Genetics 39, 212–217
(February 2007); doi:10.1038/ng1945
| Summary | Full Text (HTML / PDF) |

letter
Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution
Agnar Helgason, Snæbjörn Pálsson, Gudmar Thorleifsson, Struan F A Grant, Valur Emilsson, Steinunn Gunnarsdottir, Adebowale Adeyemo, Yuanxiu Chen, Guanjie Chen, Inga Reynisdottir, Rafn Benediktsson, Anke Hinney, Torben Hansen, Gitte Andersen, Knut Borch-Johnsen, Torben Jorgensen, Helmut Schäfer, Mezbah Faruque, Ayo Doumatey, Jie Zhou, Robert L Wilensky, Muredach P Reilly, Daniel J Rader, Yu Bagger, Claus Christiansen, Gunnar Sigurdsson, Johannes Hebebrand, Oluf Pedersen, Unnur Thorsteinsdottir, Jeffrey R Gulcher, Augustine Kong, Charles Rotimi & Kári Stefánsson
Nature Genetics 39, 218–225
(February 2007); doi:10.1038/ng1960
| Summary | Full Text (HTML / PDF) |

article
Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88
Herman J Pel et al.
Nature Biotechnology 25, 221–231
(February 2007); doi:10.1038/nbt1282
| Summary | Full Text (HTML / PDF) |

news and views
The genome of an industrial workhorse
Dan Cullen
Nature Biotechnology 25, 189–190
(February 2007); doi:10.1038/nbt0207-189
| Summary | Full Text (HTML / PDF) |

review
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
Christian Haass and Dennis J. Selkoe
Nature Reviews Molecular Cell Biology 8, 101–112
(February 2007); doi:10.1038/nrm2101
| Summary | Full Text (HTML / PDF) |

letter
Bioinformatic discovery of novel bioactive peptides
Richard J Edwards, Niamh Moran, Marc Devocelle, Aoife Kiernan, Gerardene Meade, William Signac, Martina Foy, Stephen D E Park, Eimear Dunne, Dermot Kenny and Denis C Shields
Nature Chemical Biology 3, 108–112
(February 2007); doi:10.1038/nchembio854
| Summary | Full Text (HTML / PDF) |

letter
Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
Yan Zheng, Dimitry M. Danilenko, Patricia Valdez, Ian Kasman, Jeffrey Eastham-Anderson, Jianfeng Wu and Wenjun Ouyang
Nature 445, 648–651
(15 February 2007); doi:10.1038/nature05505
| First Paragraph | Full Text (HTML / PDF) |

letter
Promotion of Hras-induced squamous carcinomas by a polymorphic variant of the Patched gene in FVB mice
Yuichi Wakabayashi, Jian-Hua Mao, Ken Brown, Michael Girardi and Allan Balmain
Nature 445, 761–765
(15 February 2007); doi:10.1038/nature05489
| First Paragraph | Full Text (HTML / PDF) |

letter
Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase
Ya-Chieh Hsu, Joshua J. Chern, Yi Cai, Mingyao Liu and Kwang-Wook Choi
Nature 445, 785–788
(15 February 2007); doi:10.1038/nature05528
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letter
Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries
Arndt F. Siekmann and Nathan D. Lawson
Nature 445, 781–784
(15 February 2007); doi:10.1038/nature05577
| First Paragraph | Full Text (HTML / PDF) |

letter
Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis
Mats Hellström, Li-Kun Phng, Jennifer J. Hofmann, Elisabet Wallgard, Leigh Coultas, Per Lindblom, Jackelyn Alva, Ann-Katrin Nilsson, Linda Karlsson, Nicholas Gaiano, Keejung Yoon, Janet Rossant, M. Luisa Iruela-Arispe, Mattias Kalén, Holger Gerhardt and Christer Betsholtz
Nature 445, 776–780
(15 February 2007); doi:10.1038/nature05571
| First Paragraph | Full Text (HTML / PDF) |

news and views
Vascular Biology: Vessel guidance
Thomas Gridley
Nature 445, 722–723
(15 February 2007); doi:10.1038/445722a
| Summary | Full Text (HTML / PDF) |

letter
Myosin VI targeting to clathrin-coated structures and dimerization is mediated by binding to Disabled-2 and PtdIns(4,5)P2
Giulietta Spudich, Margarita V. Chibalina, Josephine Sui-Yan Au, Susan D. Arden, Folma Buss & John Kendrick-Jones
Nature Cell Biology 9, 176–183
(February 2007); doi:10.1038/ncb1531
| First Paragraph | Full Text (HTML / PDF) |

letter
Interaction between β-catenin and HIF-1 promotes cellular adaptation to hypoxia
Abderrahmane Kaidi, Ann Caroline Williams & Christos Paraskeva
Nature Cell Biology 9, 210–217
(February 2007); doi:10.1038/ncb1534
| First Paragraph | Full Text (HTML / PDF) |

letter
Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation
Marie-Liesse Asselin-Labat, Kate D. Sutherland, Holly Barker, Richard Thomas, Mark Shackleton, Natasha C. Forrest, Lynne Hartley, Lorraine Robb, Frank G. Grosveld, Jacqueline van der Wees, Geoffrey J. Lindeman & Jane E. Visvader
Nature Cell Biology 9, 201–209
(February 2007); doi:10.1038/ncb1530
| First Paragraph | Full Text (HTML / PDF) |

news and views
Luminal cells GATA have it
Thea D. Tlsty
Nature Cell Biology 9, 135–136
(February 2007); doi:10.1038/ncb0207-135
| Summary | Full Text (HTML / PDF) |

review
Key factors in the organized chaos of early T cell development
Adrian C Hayday & Daniel J Pennington
Nature Immunology 8, 137–144
(February 2007); doi:10.1038/ni1436
| Summary | Full Text (HTML / PDF) |

brief communication
Epigenetic stem cell signature in cancer
Martin Widschwendter, Heidi Fiegl, Daniel Egle, Elisabeth Mueller-Holzner, Gilbert Spizzo, Christian Marth, Daniel J Weisenberger, Mihaela Campan, Joanne Young, Ian Jacobs & Peter W Laird
Nature Genetics 39, 157–158
(February 2007); doi:10.1038/ng1941
| Summary | Full Text (HTML / PDF) |

brief communication
Fanconi anemia is associated with a defect in the BRCA2 partner PALB2
Bing Xia, Josephine C Dorsman, Najim Ameziane, Yne de Vries, Martin A Rooimans, Qing Sheng, Gerard Pals, Abdellatif Errami, Eliane Gluckman, Julian Llera, Weidong Wang, David M Livingston, Hans Joenje & Johan P de Winter
Nature Genetics 39, 159–161
(February 2007); doi:10.1038/ng1942
| Summary | Full Text (HTML / PDF) |

brief communication
Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer
Sarah Reid, Detlev Schindler, Helmut Hanenberg, Karen Barker, Sandra Hanks, Reinhard Kalb, Kornelia Neveling, Patrick Kelly, Sheila Seal, Marcel Freund, Melanie Wurm, Sat Dev Batish, Francis P Lach, Sevgi Yetgin, Heidemarie Neitzel, Hany Ariffin, Marc Tischkowitz, Christopher G Mathew, Arleen D Auerbach & Nazneen Rahman
Nature Genetics 39, 162–164
(February 2007); doi:10.1038/ng1947
| Summary | Full Text (HTML / PDF) |

brief communication
Fanconi anemia and breast cancer susceptibility
Ketan J Patel
Nature Genetics 39, 142–143
(February 2007); doi:10.1038/ng0207-142
| Summary | Full Text (HTML / PDF) |

review
The evolution of gene regulation by transcription factors and microRNAs
Kevin Chen and Nikolaus Rajewsky
Nature Reviews Genetics 8, 93–103
(February 2007); doi:10.1038/nrg1990
| Summary | Full Text (HTML / PDF) |

article
Drosophila spichthyin inhibits BMP signaling and regulates synaptic growth and axonal microtubules
Xinnan Wang, W Robert Shaw, Hilda T H Tsang, Evan Reid & Cahir J O'Kane
Nature Neuroscience 10, 177–185
(February 2007); doi:10.1038/nn1841
| Summary | Full Text (HTML / PDF) |

article
C. elegans VAB-8 and UNC-73 regulate the SAX-3 receptor to direct cell and growth-cone migrations
Natsuko Watari-Goshima, Ken-ichi Ogura, Fred W Wolf, Yoshio Goshima & Gian Garriga
Nature Neuroscience 10, 169–176
(February 2007); doi:10.1038/nn1834
| Summary | Full Text (HTML / PDF) |

article
VAB-8, UNC-73 and MIG-2 regulate axon polarity and cell migration functions of UNC-40 in C. elegans
Naomi Levy-Strumpf & Joseph G Culotti
Nature Neuroscience 10, 161–168
(February 2007); doi:10.1038/nn1835
| Summary | Full Text (HTML / PDF) |

review
Lipid raft microdomains and neurotransmitter signalling
John A. Allen, Robyn A. Halverson-Tamboli and Mark M. Rasenick
Nature Reviews Neuroscience 8, 128–140
(February 2007); doi:10.1038/nrn2059
| Summary | Full Text (HTML / PDF) |

article
Axial patterning in cephalochordates and the evolution of the organizer
Jr-Kai Yu, Yutaka Satou, Nicholas D. Holland, Tadasu Shin-I, Yuji Kohara, Noriyuki Satoh, Marianne Bronner-Fraser and Linda Z. Holland
Nature 445, 613–617
(8 February 2007); doi:10.1038/nature05472
| Summary | Full Text (HTML / PDF) |

letter
Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation
Guillermo Barreto, Andrea Schäfer, Joachim Marhold, Dirk Stach, Suresh K. Swaminathan, Vikas Handa, Gabi Döderlein, Nicole Maltry, Wei Wu, Frank Lyko and Christof Niehrs
Nature 445, 671–675
(8 February 2007); doi:10.1038/nature05515
| First Paragraph | Full Text (HTML / PDF) |

letter
Restoration of p53 function leads to tumour regression in vivo
Andrea Ventura, David G. Kirsch, Margaret E. McLaughlin, David A. Tuveson, Jan Grimm, Laura Lintault, Jamie Newman, Elizabeth E. Reczek, Ralph Weissleder and Tyler Jacks
Nature 445, 661–665
(8 February 2007); doi:10.1038/nature05541
| First Paragraph | Full Text (HTML / PDF) |

news and views
Cancer biology: Gone but not forgotten
Norman E. Sharpless and Ronald A. DePinho
Nature 445, 606–607
(8 February 2007); doi:10.1038/nature05567
| Summary | Full Text (HTML / PDF) |

article
Loss of centrosome integrity induces p38—p53—p21-dependent G1—S arrest
Keith Mikule, Benedicte Delaval, Philipp Kaldis, Agata Jurcyzk, Polla Hergert & Stephen Doxsey
Nature Cell Biology 9, 160–170
(February 2007); doi:10.1038/ncb1529
| Summary | Full Text (HTML / PDF) |

letter
Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit
Ulrich K. Binné, Marie K. Classon, Frederick A. Dick, Wenyi Wei, Michael Rape, William G. Kaelin Jr., Anders M. Näär & Nicholas J. Dyson
Nature Cell Biology 9, 225–232
(February 2007); doi:10.1038/ncb1532
| First Paragraph | Full Text (HTML / PDF) |

news and views
The pRb-Cdh1-p27 autoamplifying network
Patricia G. Santamaría & Michele Pagano
Nature Cell Biology 9, 137–138
(February 2007); doi:10.1038/ncb0207-137
| Summary | Full Text (HTML / PDF) |

review
Multiple levels of cyclin specificity in cell-cycle control
Joanna Bloom and Frederick R. Cross
Nature Reviews Molecular Cell Biology 8, 149–160
(February 2007); doi:10.1038/nrm2105
| Summary | Full Text (HTML / PDF) |

news and views
The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens
Yen-Michael S Hsu, Yongliang Zhang, Yun You, Donghai Wang, Hongxiu Li, Omar Duramad, Xiao-Feng Qin, Chen Dong & Xin Lin
Nature Immunology 8, 198–205
(February 2007); doi:10.1038/ni1426
| Summary | Full Text (HTML / PDF) |

news and views
A pair of 9s: it's in the CARDs
David M Underhill & Takahiro Shimada
Nature Immunology 8, 122–124
(February 2007); doi:10.1038/ni0207-122
| Summary | Full Text (HTML / PDF) |

review
Transcription factors in myeloid development: balancing differentiation with transformation
Frank Rosenbauer and Daniel G. Tenen
Nature Reviews Immunology 7, 105–117
(February 2007); doi:10.1038/nri2024
| Summary | Full Text (HTML / PDF) |

article
Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity
Jane A Leopold, Aamir Dam, Bradley A Maron, Anne W Scribner, Ronglih Liao, Diane E Handy, Robert C Stanton, Bertram Pitt & Joseph Loscalzo
Nature Medicine 13, 189–197
(February 2007); doi:10.1038/nm1545
| Summary | Full Text (HTML / PDF) |

article
Dickkopf-1 is a master regulator of joint remodeling
Danielle Diarra, Marina Stolina, Karin Polzer, Jochen Zwerina, Michael S Ominsky, Denise Dwyer, Adelheid Korb, Josef Smolen, Markus Hoffmann, Clemens Scheinecker, Desiree van der Heide, Robert Landewe, Dave Lacey, William G Richards & Georg Schett
Nature Medicine 13, 156–163
(February 2007); doi:10.1038/nm1538
| Summary | Full Text (HTML / PDF) |

news and views
Eating bone or adding it: the Wnt pathway decides
Steven R Goldring & Mary B Goldring
Nature Medicine 13, 133–134
(February 2007); doi:10.1038/nm0207-133
| Summary | Full Text (HTML / PDF) |

letter
Angiotensin II type 1 receptor blockade attenuates TGF-β-induced failure of muscle regeneration in multiple myopathic states
Ronald D Cohn, Christel van Erp, Jennifer P Habashi, Arshia A Soleimani, Erin C Klein, Matthew T Lisi, Matthew Gamradt, Colette M ap Rhys, Tammy M Holm, Bart L Loeys, Francesco Ramirez, Daniel P Judge, Christopher W Ward & Harry C Dietz
Nature Medicine 13, 204–210
(February 2007); doi:10.1038/nm1536
| First Paragraph | Full Text (HTML / PDF) |

news and views
ACE inhibitor bulks up muscle
Jeffrey S Chamberlain
Nature Medicine 13, 125–126
(February 2007); doi:10.1038/nm0207-125
| Summary | Full Text (HTML / PDF) |

review
G-protein-coupled receptors and cancer
Robert T. Dorsam and J. Silvio Gutkind
Nature Reviews Cancer 7, 79–94
(February 2007); doi:10.1038/nrc2069
| Summary | Full Text (HTML / PDF) |

perspective
The tumour microenvironment as a target for chemoprevention
Adriana Albini and Michael B. Sporn
Nature Reviews Cancer 7,
(February 2007); doi:10.1038/nrc2067
| Summary | Full Text (HTML / PDF) |

perspective
Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug
Paul A Marks & Ronald Breslow
Nature Biotechnology 25, 84–90
(February 2007); doi:10.1038/nbt1272
| Summary | Full Text (HTML / PDF) |

perspective
Why is cancer drug discovery so difficult?
Alexander Kamb, Susan Wee and Christoph Lengauer
Nature Reviews Drug Discovery 6, 115–120
(February 2007); doi:10.1038/nrd2155
| Summary | Full Text (HTML / PDF) |

article
Asymmetric deceleration of ClpB or Hsp104 ATPase activity unleashes protein-remodeling activity
Shannon M Doyle, James Shorter, Michal Zolkiewski, Joel R Hoskins, Susan Lindquist & Sue Wickner
Nature Structural & Molecular Biology 14, 114–122
(February 2007); doi:10.1038/nsmb1198
| Summary | Full Text (HTML / PDF) |

article
The guanylate kinase domain of the MAGUK PSD-95 binds dynamically to a conserved motif in MAP1a
Michael L Reese, Srikanth Dakoji, David S Bredt & Volker Dötsch
Nature Structural & Molecular Biology 14, 155–163
(February 2007); doi:10.1038/nsmb1195
| Summary | Full Text (HTML / PDF) |

brief communication
Direct interactions between NEDD8 and ubiquitin E2 conjugating enzymes upregulate cullin-based E3 ligase activity
Eri Sakata, Yoshiki Yamaguchi, Yasuhiro Miyauchi, Kazuhiro Iwai, Tomoki Chiba, Yasushi Saeki, Noriyuki Matsuda, Keiji Tanaka & Koichi Kato
Nature Structural & Molecular Biology 14, 167–168
(February 2007); doi:10.1038/nsmb1191
| Summary | Full Text (HTML / PDF) |

letter
Transcription factor control of asymmetric cell divisions that establish the stomatal lineage
Cora A. MacAlister, Kyoko Ohashi-Ito and Dominique C. Bergmann
Nature 445, 537–540
(1 February 2007); doi:10.1038/nature05491
| First Paragraph | Full Text (HTML / PDF) |

letter
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
Lindsey J. Macpherson, Adrienne E. Dubin, Michael J. Evans, Felix Marr, Peter G. Schultz, Benjamin F. Cravatt and Ardem Patapoutian
Nature 445, 541–545
(1 February 2007); doi:10.1038/nature05544
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letter
bicoid RNA localization requires specific binding of an endosomal sorting complex
Uwe Irion and Daniel St Johnston
Nature 445, 554–558
(1 February 2007); doi:10.1038/nature05503
| First Paragraph | Full Text (HTML / PDF) |

letter
The twisted ion-permeation pathway of a resting voltage-sensing domain
Francesco Tombola, Medha M. Pathak, Pau Gorostiza and Ehud Y. Isacoff
Nature 445, 546–549
(1 February 2007); doi:10.1038/nature05396
| First Paragraph | Full Text (HTML / PDF) |

letter
Structure prediction for the down state of a potassium channel voltage sensor
Michael Grabe, Helen C. Lai, Monika Jain, Yuh Nung Jan and Lily Yeh Jan
Nature 445, 550–553
(1 February 2007); doi:10.1038/nature05494
| First Paragraph | Full Text (HTML / PDF) |

article
Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo
Tudor A. Fulga, Ilan Elson-Schwab, Vikram Khurana, Michelle L. Steinhilb, Tara L. Spires, Bradley T. Hyman & Mel B. Feany
Nature Cell Biology 9, 139–148
(February 2007); doi:10.1038/ncb1528
| Summary | Full Text (HTML / PDF) |

article
The energy sensing LKB1-AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis
Jiyong Liang, Shan H. Shao, Zhi-Xiang Xu, Bryan Hennessy, Zhiyong Ding, Michelle Larrea, Seiji Kondo, Dan J. Dumont, Jordan U. Gutterman, Cheryl L. Walker, Joyce M. Slingerland & Gordon B. Mills
Nature Cell Biology 9, 218–224
(February 2007); doi:10.1038/ncb1537
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article
Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-κB transcription factors
June L Round, Lisa A Humphries, Tamar Tomassian, Paul Mittelstadt, Min Zhang & M Carrie Miceli
Nature Immunology 8, 154–161
(February 2007); doi:10.1038/ni1422
| Summary | Full Text (HTML / PDF) |

news and views
Choreography of MAGUKs during T cell activation
Mercedes Rincón & Roger J Davis
Nature Immunology 8, 126–127
(February 2007); doi:10.1038/ni0207-126
| Summary | Full Text (HTML / PDF) |

review
Regulation of T-cell activation by the cytoskeleton
Daniel D. Billadeau, Jeffrey C. Nolz and Timothy S. Gomez
Nature Reviews Immunology 7, 131–143
(February 2007); doi:10.1038/nri2021
| Summary | Full Text (HTML / PDF) |

article
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
Ekaterina Rogaeva, Yan Meng, Joseph H Lee, Yongjun Gu, Toshitaka Kawarai, Fanggeng Zou, Taiichi Katayama, Clinton T Baldwin, Rong Cheng, Hiroshi Hasegawa, Fusheng Chen, Nobuto Shibata, Kathryn L Lunetta, Raphaelle Pardossi-Piquard, Christopher Bohm, Yosuke Wakutani, L Adrienne Cupples, Karen T Cuenco, Robert C Green, Lorenzo Pinessi, Innocenzo Rainero, Sandro Sorbi, Amalia Bruni, Ranjan Duara, Robert P Friedland, Rivka Inzelberg, Wolfgang Hampe, Hideaki Bujo, You-Qiang Song, Olav M Andersen, Thomas E Willnow, Neill Graff-Radford, Ronald C Petersen, Dennis Dickson, Sandy D Der, Paul E Fraser, Gerold Schmitt-Ulms, Steven Younkin, Richard Mayeux, Lindsay A Farrer & Peter St George-Hyslop
Nature Genetics 39, 168–177
(February 2007); doi:10.1038/ng1943
| Summary | Full Text (HTML / PDF) |

review
Frizzled/PCP signalling: a conserved mechanism regulating cell polarity and directed motility
Jessica R. K. Seifert and Marek Mlodzik
Nature Reviews Genetics 8, 131–143
(February 2007); doi:10.1038/nrg2042
| Summary | Full Text (HTML / PDF) |

article
Drosophila spichthyin inhibits BMP signaling and regulates synaptic growth and axonal microtubules
Xinnan Wang, W Robert Shaw, Hilda T H Tsang, Evan Reid & Cahir J O'Kane
Nature Neuroscience 10, 177–185
(February 2007); doi:10.1038/nn1841
| Summary | Full Text (HTML / PDF) |

article
Notch signal organizes the Drosophila olfactory circuitry by diversifying the sensory neuronal lineages
Keita Endo, Tomoko Aoki, Yuka Yoda, Ken-ichi Kimura & Chihiro Hama
Nature Neuroscience 10, 153–160
(February 2007); doi:10.1038/nn1832
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news and views
Olfactory identity kicked up a NOTCH
Stefan Fuss, Arzu Çelik & Claude Desplan
Nature Neuroscience 10, 138–140
(February 2007); doi:10.1038/nn0207-138
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review
Regulatory mechanisms of AMPA receptors in synaptic plasticity
Victor A. Derkach, Michael C. Oh, Eric S. Guire and Thomas R. Soderling
Nature Reviews Neuroscience 8, 101–113
(February 2007); doi:10.1038/nrn2055
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article
Rapid identification of functionally critical amino acids in a G protein-coupled receptor
Bo Li, Marco Scarselli, Christopher D Knudsen, Soo-Kyung Kim, Kenneth A Jacobson, Sara M McMillin & Jürgen Wess
Nature Methods 4, 169–174
(February 2007); doi:10.1038/nmeth990
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review
Imaging single events at the cell membrane
Jyoti K Jaiswal and Sanford M Simon
Nature Chemical Biology 3, 92–98
(February 2007); doi:10.1038/nchembio855
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