The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.
Click here for free access to the 'Featured Articles' section, with new articles every week.
letter Opioids block long-term potentiation of inhibitory synapses
Fereshteh S. Nugent, Esther C. Penick & Julie A. Kauer Nature446, 1086–1090
(26 April 2007); doi:10.1038/nature05726
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letter UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis
Schuichi Koizumi, Yukari Shigemoto-Mogami, Kaoru Nasu-Tada, Yoichi Shinozaki, Keiko Ohsawa, Makoto Tsuda, Bhalchandra V. Joshi, Kenneth A. Jacobson, Shinichi Kohsaka & Kazuhide Inoue Nature446, 1091–1095
(26 April 2007); doi:10.1038/nature05704
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news and views Neuroscience: The brain's garbage men
Helmut Kettenmann Nature446, 987–989
(26 April 2007); doi:10.1038/nature05713
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letter Phosphorylation of Erp1 by p90rsk is required for cytostatic factor arrest in Xenopus laevis eggs
Tomoko Nishiyama, Keita Ohsumi & Takeo Kishimoto Nature446, 1096–1099
(26 April 2007); doi:10.1038/nature05696
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letter A direct link of the Mos–MAPK pathway to Erp1/Emi2 in meiotic arrest of Xenopuslaevis eggs
Daigo Inoue, Munemichi Ohe, Yoshinori Kanemori, Toshiya Nobui & Noriyuki Sagata Nature446, 1100–1104
(26 April 2007); doi:10.1038/nature05688
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letter Oestrogen signalling inhibits invasive phenotype by repressing RelB and its target BCL2
Xiaobo Wang, Karine Belguise, Nathalie Kersual, Kathrin H. Kirsch, Nora D. Mineva, Florence Galtier, Dany Chalbos & Gail E. Sonenshein Nature Cell Biology9, 470–478
(April 2007); doi:10.1038/ncb1559
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news and views NF-κB links oestrogen receptor signalling and EMT
Derek C. Radisky & Mina J. Bissell Nature Cell Biology9, 361–363
(April 2007); doi:10.1038/ncb0407-361
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letter Normal epidermal differentiation but impaired skin-barrier formation upon keratinocyte-restricted IKK1 ablation
Ralph Gareus, Marion Huth, Bernadette Breiden, Arianna Nenci, Nora Rösch, Ingo Haase, Wilhelm Bloch, Konrad Sandhoff & Manolis Pasparakis Nature Cell Biology9, 461–469
(April 2007); doi:10.1038/ncb1560
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review Netrins: beyond the brain
Vincenzo Cirulli & Mayra Yebra Nature Reviews Molecular Cell Biology8, 296–306
(April 2007); doi:10.1038/nrm2142
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article Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells
Katharina Aschenbrenner, Louise M D'Cruz, Elisabeth H Vollmann, Maria Hinterberger, Jan Emmerich, Lee Kim Swee, Antonius Rolink & Ludger Klein Nature Immunology8, 351–358
(April 2007); doi:10.1038/ni1444
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article Regulatory T cell development in the absence of functional Foxp3
Wen Lin, Dipica Haribhai, Lance M Relland, Nga Truong, Marc R Carlson, Calvin B Williams & Talal A Chatila Nature Immunology8, 359–368
(April 2007); doi:10.1038/ni1445
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news and views Foxp3 and Aire in thymus-generated Treg cells: a link in self-tolerance
Takashi Nomura & Shimon Sakaguchi Nature Immunology8, 333–334
(April 2007); doi:10.1038/ni0407-333
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perspective FOXP3 modifies the phenotypic and functional properties of regulatory T cells
Daniel J. Campbell & Steven F. Ziegler Nature Reviews Immunology7, 305–310
(April 2007); doi:10.1038/nri2061
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news and views Providing AID to p53 mutagenesis
Shigeo Takaishi & Timothy C Wang Nature Medicine13, 404–406
(April 2007); doi:10.1038/nm0407-404
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article Angiogenic inhibition reduces germinal matrix hemorrhage
Praveen Ballabh, Hongmin Xu, Furong Hu, Alex Braun, Kira Smith, Aracelie Rivera, Nanhong Lou, Zoltan Ungvari, Steven A Goldman, Anna Csiszar & Maiken Nedergaard Nature Medicine13, 477–485
(April 2007); doi:10.1038/nm1558
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review Inflammation in prostate carcinogenesis
Angelo M. De Marzo, Elizabeth A. Platz, Siobhan Sutcliffe, Jianfeng Xu, Henrik Grönberg, Charles G. Drake, Yasutomo Nakai, William B. Isaacs & William G. Nelson Nature Reviews Cancer7, 256–269
(April 2007); doi:10.1038/nrc2090
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review Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation
Masao Matsuoka & Kuan-Teh Jeang Nature Reviews Cancer7, 270–280
(April 2007); doi:10.1038/nrc2111
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article A module of negative feedback regulators defines growth factor signaling
Ido Amit, Ami Citri, Tal Shay, Yiling Lu, Menachem Katz, Fan Zhang, Gabi Tarcic, Doris Siwak, John Lahad, Jasmine Jacob-Hirsch, Ninette Amariglio, Nora Vaisman, Eran Segal, Gideon Rechavi, Uri Alon, Gordon B Mills, Eytan Domany & Yosef Yarden Nature Genetics39, 503–512
(April 2007); doi:10.1038/ng1987
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commentary Recommendations of the 2006 Human Variome Project meeting
Richard G.H. Cotton Nature Genetics39, 433–436
(April 2007); doi:10.1038/ng2024
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review Epigenetic signatures of stem-cell identity
Mikhail Spivakov and Amanda G. Fisher Nature Reviews Genetics8, 263–271
(April 2007); doi:10.1038/nrg2046
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article The Drosophila DCO mutation suppresses age-related memory impairment without affecting lifespan
Daisuke Yamazaki, Junjiro Horiuchi, Yasuko Nakagami, Shintaro Nagano, Takuya Tamura & Minoru Saitoe Nature Neuroscience10, 478–484
(April 2007); doi:10.1038/nn1863
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article Rho mediates calcium-dependent activation of p38α and subsequent excitotoxic cell death
Maria M Semenova, Anu M J Mäki-Hokkonen, Jiong Cao, Vladislav Komarovski, K Marjut Forsberg, Milla Koistinaho, Eleanor T Coffey & Michael J Courtney Nature Neuroscience10, 436–443
(April 2007); doi:10.1038/nn1869
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perspective Channel, neuronal and clinical function in sodium channelopathies: from genotype to phenotype
Stephen G Waxman Nature Neuroscience10, 405–409
(April 2007); doi:10.1038/nn1857
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review The neuronal background K2P channels: focus on TREK1
Eric Honoré Nature Reviews Neuroscience8, 251–261
(April 2007); doi:10.1038/nrn2117
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article Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338
Markiyan Oliynyk, Markiyan Samborskyy, John B Lester, Tatiana Mironenko, Nataliya Scott, Shilo Dickens, Stephen F Haydock & Peter F Leadlay Nature Biotechnology25, 447–453
(April 2007); doi:10.1038/nbt1297
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news and views Antibiotic production from the ground up
Leonard Katz & Chaitan Khosla Nature Biotechnology25, 428–429
(April 2007); doi:10.1038/nbt0407-428
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article An anti-infective peptide that selectively modulates the innate immune response
Monisha G Scott, Edie Dullaghan, Neeloffer Mookherjee, Natalie Glavas, Matthew Waldbrook, Annick Thompson, Aikun Wang, Ken Lee, Silvana Doria, Pam Hamill, Jie Jessie Yu, Yuexin Li, Oreola Donini, M Marta Guarna, B Brett Finlay, John R North & Robert E W Hancock Nature Biotechnology25, 465–472
(April 2007); doi:10.1038/nbt1288
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review Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases
Roy Pettipher, Trevor T. Hansel & Richard Armer Nature Reviews Drug Discovery6, 313–325
(April 2007); doi:10.1038/nrd2266
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perspective Angiogenesis: an organizing principle for drug discovery?
Judah Folkman Nature Reviews Drug Discovery6, 273–286
(April 2007); doi:10.1038/nrd2115
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article Sequence-specific dynamics modulate recognition specificity in WW domains
Tao Peng, John S Zintsmaster, Andrew T Namanja & Jeffrey W Peng Nature Structural & Molecular Biology14, 325–331
(April 2007); doi:10.1038/nsmb1207
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article Genome-wide resources of endoribonuclease-prepared short interfering RNAs for specific loss-of-function studies
Ralf Kittler, Vineeth Surendranath, Anne-Kristin Heninger, Mikolaj Slabicki, Mirko Theis, Gabriele Putz, Kristin Franke, Antonio Caldarelli, Hannes Grabner, Karol Kozak, Jan Wagner, Effi Rees, Bernd Korn, Corina Frenzel, Christoph Sachse, Birte Sönnichsen, Jie Guo, Janell Schelter, Julja Burchard, Peter S Linsley, Aimee L Jackson, Bianca Habermann & Frank Buchholz Nature Methods4, 337–344
(April 2007); doi:10.1038/nmeth1025
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brief communication Multiplexed protein detection by proximity ligation for cancer biomarker validation
Simon Fredriksson, William Dixon, Hanlee Ji, Albert C Koong, Michael Mindrinos & Ronald W Davis Nature Methods4, 327–329
(April 2007); doi:10.1038/nmeth1020
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letter An RNA G-quadruplex in the 5' UTR of the NRAS proto-oncogene modulates translation
Sunita Kumari, Anthony Bugaut, Julian L Huppert and Shankar Balasubramanian Nature Chemical Biology3, 218–221
(April 2007); doi:10.1038/nchembio864
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news and views The rule of four
Bruce A Armitage Nature Chemical Biology3, 203–204
(April 2007); doi:10.1038/nchembio0407-203
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article Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities
Frank Stegmeier, Michael Rape, Viji M. Draviam, Grzegorz Nalepa, Mathew E. Sowa, Xiaolu L. Ang, E. Robert McDonald III, Mamie Z. Li, Gregory J. Hannon, Peter K. Sorger, Marc W. Kirschner, J. Wade Harper & Stephen J. Elledge Nature446, 876–881
(19 April 2007); doi:10.1038/nature05694
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article Opposing LSD1 complexes function in developmental gene activation and repression programmes
Jianxun Wang, Kathleen Scully, Xiaoyan Zhu, Ling Cai, Jie Zhang, Gratien G. Prefontaine, Anna Krones, Kenneth A. Ohgi, Ping Zhu, Ivan Garcia-Bassets, Forrest Liu, Havilah Taylor, Jean Lozach, Friederike L. Jayes, Kenneth S. Korach, Christopher K. Glass, Xiang-Dong Fu & Michael G. Rosenfeld Nature446, 882–887
(19 April 2007); doi:10.1038/nature05671
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letter TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity
Michaela U. Gack, Young C. Shin, Chul-Hyun Joo, Tomohiko Urano, Chengyu Liang, Lijun Sun, Osamu Takeuchi, Shizuo Akira, Zhijian Chen, Satoshi Inoue & Jae U. Jung Nature446, 916–920
(19 April 2007); doi:10.1038/nature05732
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letter Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation
S. K. Reddy, M. Rape, W. A. Margansky & M. W. Kirschner Nature446, 921–925
(19 April 2007); doi:10.1038/nature05734
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letter A stepwise mechanism for acetylcholine receptor channel gating
Prasad Purohit, Ananya Mitra & Anthony Auerbach Nature446, 930–933
(19 April 2007); doi:10.1038/nature05721
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news and views Cell biology: The checkpoint brake relieved
Jan-Michael Peters Nature446, 868–869
(19 April 2007); doi:10.1038/446868a
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letter Uncoupling proteins 2 and 3 are fundamental for mitochondrial Ca2+ uniport
Michael Trenker, Roland Malli, Ismene Fertschai, Sanja Levak-Frank & Wolfgang F. Graier Nature Cell Biology9, 445–452
(April 2007); doi:10.1038/ncb1556
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letter R-type Ca2+-channel-evoked CICR regulates glucose-induced somatostatin secretion
Quan Zhang, Martin Bengtsson, Chris Partridge, Albert Salehi, Matthias Braun, Roger Cox, Lena Eliasson, Paul RV Johnson, Erik Renström, Toni Schneider, Per-Olof Berggren, Sven Göpel, Frances M Ashcroft & Patrik Rorsman Nature Cell Biology9, 453–460
(April 2007); doi:10.1038/ncb1563
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review Siglecs and their roles in the immune system
Paul R. Crocker, James C. Paulson & Ajit Varki Nature Reviews Immunology7, 255–266
(April 2007); doi:10.1038/nri2056
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article Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1
Susanne Ludwiczek, Igor Theurl, Martina U Muckenthaler, Martin Jakab, Sabine M Mair, Milan Theurl, Judit Kiss, Markus Paulmichl, Matthias W Hentze, Markus Ritter & Guenter Weiss Nature Medicine13, 448–454
(April 2007); doi:10.1038/nm1542
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article Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood
Stephen R Clark, Adrienne C Ma, Samantha A Tavener, Braedon McDonald, Zahra Goodarzi, Margaret M Kelly, Kamala D Patel, Subhadeep Chakrabarti, Erin McAvoy, Gary D Sinclair, Elizabeth M Keys, Emma Allen-Vercoe, Rebekah DeVinney, Christopher J Doig, Francis H Y Green & Paul Kubes Nature Medicine13, 463–469
(April 2007); doi:10.1038/nm1565
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news and views Netting bacteria in sepsis
Constantin Urban & Arturo Zychlinsky Nature Medicine13, 403–404
(April 2007); doi:10.1038/nm0407-403
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letter The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2
Baofeng Yang, Huixian Lin, Jiening Xiao, Yanjie Lu, Xiaobin Luo, Baoxin Li, Ying Zhang, Chaoqian Xu, Yunlong Bai, Huizhen Wang, Guohao Chen & Zhiguo Wang Nature Medicine13, 486–491
(April 2007); doi:10.1038/nm1569
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technical report MRI detection of transcriptional regulation of gene expression in transgenic mice
Batya Cohen, Keren Ziv, Vicki Plaks, Tomer Israely, Vyacheslav Kalchenko, Alon Harmelin, Laura E Benjamin & Michal Neeman Nature Medicine13, 498–503
(April 2007); doi:10.1038/nm1497
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technical report Molecular imaging of VEGF receptors in angiogenic vasculature with single-chain VEGF-based probes
Marina V Backer, Zoya Levashova, Vimalkumar Patel, Brian T Jehning, Kevin Claffey, Francis G Blankenberg & Joseph M Backer Nature Medicine13, 504–509
(April 2007); doi:10.1038/nm1522
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review The impact of translocations and gene fusions on cancer causation
Felix Mitelman, Bertil Johansson & Fredrik Mertens Nature Reviews Cancer7, 233–245
(April 2007); doi:10.1038/nrc2091
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review Reprogramming metastatic tumour cells with embryonic microenvironments
Mary J. C. Hendrix, Elisabeth A. Seftor, Richard E. B. Seftor, Jennifer Kasemeier-Kulesa, Paul M. Kulesa & Lynne-Marie Postovit Nature Reviews Cancer7, 246–255
(April 2007); doi:10.1038/nrc2108
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letter A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis
Chiea C Khor, Stephen J Chapman, Fredrik O Vannberg, Aisling Dunne, Caroline Murphy, Edmund Y Ling, Angela J Frodsham, Andrew J Walley, Otto Kyrieleis, Amir Khan, Christophe Aucan, Shelley Segal, Catrin E Moore, Kyle Knox, Sarah J Campbell, Christian Lienhardt, Anthony Scott, Peter Aaby, Oumou Y Sow, Robert T Grignani, Jackson Sillah, Giorgio Sirugo, Nobert Peshu, Thomas N Williams, Kathryn Maitland, Robert J O Davies, Dominic P Kwiatkowski, Nicholas P Day, Djamel Yala, Derrick W Crook, Kevin Marsh, James A Berkley, Luke A J O'Neill & Adrian V S Hill Nature Genetics39, 523–528
(April 2007); doi:10.1038/ng1976
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review Cancer epigenomics: DNA methylomes and histone-modification maps
Manel Esteller Nature Reviews Genetics8, 286–298
(April 2007); doi:10.1038/nrg2005
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article Reversal of neurosteroid effects at α4β2δ GABAA receptors triggers anxiety at puberty
Hui Shen, Qi Hua Gong, Chiye Aoki, Maoli Yuan, Yevgeniy Ruderman, Michael Dattilo, Keith Williams & Sheryl S Smith Nature Neuroscience10, 469–477
(April 2007); doi:10.1038/nn1868
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news and views GABA receptors make teens resistant to input
Margaret M McCarthy Nature Neuroscience10, 397–399
(April 2007); doi:10.1038/nn0407-397
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brief communication Reporter proteins for in vivo fluorescence without oxygen
Thomas Drepper, Thorsten Eggert, Franco Circolone, Achim Heck, Ulrich Krauß, Jan-Karl Guterl, Marion Wendorff, Aba Losi, Wolfgang Gärtner & Karl-Erich Jaeger Nature Biotechnology25, 443–445
(April 2007); doi:10.1038/nbt1293
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review Potential therapeutic applications of autophagy
David C. Rubinsztein, Jason E. Gestwicki, Leon O. Murphy & Daniel J. Klionsky Nature Reviews Drug Discovery6, 304–312
(April 2007); doi:10.1038/nrd2272
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review Peptidoglycan recognition proteins: pleiotropic sensors and effectors of antimicrobial defences
Julien Royet & Roman Dziarski Nature Reviews Microbiology5, 264–277
(April 2007); doi:10.1038/nrmicro1620
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brief communication Subunit counting in membrane-bound proteins
Maximilian H Ulbrich & Ehud Y Isacoff Nature Methods4, 319–321
(April 2007); doi:10.1038/nmeth1024
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brief communication Single-molecule analysis of DNA-protein complexes using nanopores
Breton Hornblower, Amy Coombs, Richard D Whitaker, Anatoly Kolomeisky, Stephen J Picone, Amit Meller & Mark Akeson Nature Methods4, 315–317
(April 2007); doi:10.1038/nmeth1021
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article Structure-guided development of affinity probes for tyrosine kinases using chemical genetics
Jimmy A Blair, Daniel Rauh, Charles Kung, Cai-Hong Yun, Qi-Wen Fan, Haridas Rode, Chao Zhang, Michael J Eck, William A Weiss and Kevan M Shokat Nature Chemical Biology3, 229–238
(April 2007); doi:10.1038/nchembio866
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article Mediators of vascular remodelling co-opted for sequential steps in lung metastasis
Gaorav P. Gupta, Don X. Nguyen, Anne C. Chiang, Paula D. Bos, Juliet Y. Kim, Cristina Nadal, Roger R. Gomis, Katia Manova-Todorova & Joan Massagué Nature446, 765–770
(11 April 2007); doi:10.1038/nature05760
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news and views Cancer: Division of labour
Gerhard Christofori Nature446, 735–735
(11 April 2007); doi:10.1038/446735a
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letter A mirror-symmetric cell division that orchestrates neuroepithelial morphogenesis
Marcel Tawk, Claudio Araya, Dave A. Lyons, Alexander M. Reugels, Gemma C. Girdler, Philippa R. Bayley, David R. Hyde, Masazumi Tada & Jonathan D. W. Clarke Nature446, 797–800
(11 April 2007); doi:10.1038/nature05722
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letter Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry
Matthew J. Evans, Thomas von Hahn, Donna M. Tscherne, Andrew J. Syder, Maryline Panis, Benno Wölk, Theodora Hatziioannou, Jane A. McKeating, Paul D. Bieniasz & Charles M. Rice Nature446, 801–805
(11 April 2007); doi:10.1038/nature05654
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letter Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map
Sean R. Collins, Kyle M. Miller, Nancy L. Maas, Assen Roguev, Jeffrey Fillingham, Clement S. Chu, Maya Schuldiner, Marinella Gebbia, Judith Recht, Michael Shales, Huiming Ding, Hong Xu, Junhong Han, Kristin Ingvarsdottir, Benjamin Cheng, Brenda Andrews, Charles Boone, Shelley L. Berger, Phil Hieter, Zhiguo Zhang, Grant W. Brown, C. James Ingles, Andrew Emili, C. David Allis, David P. Toczyski, Jonathan S. Weissman, Jack F. Greenblatt & Nevan J. Krogan Nature446, 806–810
(11 April 2007); doi:10.1038/nature05649
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letter Conserved factors regulate signalling in Arabidopsis thaliana shoot and root stem cell organizers
Ananda K. Sarkar, Marijn Luijten, Shunsuke Miyashima, Michael Lenhard, Takashi Hashimoto, Keiji Nakajima, Ben Scheres, Renze Heidstra & Thomas Laux Nature446, 811–814
(11 April 2007); doi:10.1038/nature05703
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letter Synthetic lethal screen identification of chemosensitizer loci in cancer cells
Angelique W. Whitehurst, Brian O. Bodemann, Jessica Cardenas, Deborah Ferguson, Luc Girard, Michael Peyton, John D. Minna, Carolyn Michnoff, Weihua Hao, Michael G. Roth, Xian-Jin Xie & Michael A. White Nature446, 815–819
(11 April 2007); doi:10.1038/nature05697
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article HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability
Spencer J. Collis, Louise J. Barber, Allison J. Clark, Julie S. Martin, Jordan D. Ward & Simon J. Boulton Nature Cell Biology9, 391–401
(April 2007); doi:10.1038/ncb1555
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letter Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1
Rüdiger Neef, Ulrike Gruneberg, Robert Kopajtich, Xiuling Li, Erich A. Nigg, Herman Sillje & Francis A. Barr Nature Cell Biology9, 436–444
(April 2007); doi:10.1038/ncb1557
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letter C-terminal modifications regulate MDM2 dissociation and nuclear export of p53
Stephanie Carter, Oliver Bischof, Anne Dejean & Karen H. Vousden Nature Cell Biology9, 428–435
(April 2007); doi:10.1038/ncb1562
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review p53 in health and disease
Karen H. Vousden & David P. Lane Nature Reviews Molecular Cell Biology8, 275–283
(April 2007); doi:10.1038/nrm2147
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article Reversible contraction by looping of the Tcra and Tcrb loci in rearranging thymocytes
Jane A Skok, Ramiro Gisler, Maria Novatchkova, Deborah Farmer, Wouter de Laat & Meinrad Busslinger Nature Immunology8, 378–387
(April 2007); doi:10.1038/ni1448
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article Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance
Lisa A Lesniewski, Sarah E Hosch, Jaap G Neels, Carl de Luca, Mohammad Pashmforoush, Carey N Lumeng, Shian-Huey Chiang, Miriam Scadeng, Alan R Saltiel & Jerrold M Olefsky Nature Medicine13, 455–462
(April 2007); doi:10.1038/nm1550
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review Protein kinase C and other diacylglycerol effectors in cancer
Erin M. Griner & Marcelo G. Kazanietz Nature Reviews Cancer7, 281–294
(April 2007); doi:10.1038/nrc2110
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article Structural basis for autoinhibition of Notch
Wendy R Gordon, Didem Vardar-Ulu, Gavin Histen, Cheryll Sanchez-Irizarry, Jon C Aster & Stephen C Blacklow Nature Structural & Molecular Biology14, 295–300
(April 2007); doi:10.1038/nsmb1227
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article Mechanism of auxin perception by the TIR1 ubiquitin ligase
Xu Tan, Luz Irina A. Calderon-Villalobos, Michal Sharon, Changxue Zheng, Carol V. Robinson, Mark Estelle & Ning Zheng Nature446, 640–645
(5 April 2007); doi:10.1038/nature05731
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news and views Plant biology: Sticking with auxin
Tom Guilfoyle Nature446, 621–622
(5 April 2007); doi:10.1038/446621a
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letter Semaphorin 7A initiates T-cell-mediated inflammatory responses through α1β1 integrin
Kazuhiro Suzuki, Tatsusada Okuno, Midori Yamamoto, R. Jeroen Pasterkamp, Noriko Takegahara, Hyota Takamatsu, Tomoe Kitao, Junichi Takagi, Paul D. Rennert, Alex L. Kolodkin, Atsushi Kumanogoh & Hitoshi Kikutani Nature446, 680–684
(5 April 2007); doi:10.1038/nature05652
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letter Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
Masahiro Ono, Hiroko Yaguchi, Naganari Ohkura, Issay Kitabayashi, Yuko Nagamura, Takashi Nomura, Yoshiki Miyachi, Toshihiko Tsukada & Shimon Sakaguchi Nature446, 685–689
(5 April 2007); doi:10.1038/nature05673
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letter Myc deletion rescues Apc deficiency in the small intestine
Owen J. Sansom, Valerie S. Meniel, Vanesa Muncan, Toby J. Phesse, Julie A. Wilkins, Karen R. Reed, J. Keith Vass, Dimitris Athineos, Hans Clevers & Alan R. Clarke Nature446, 676–679
(5 April 2007); doi:10.1038/nature05674
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letter Nuclear cytokine-activated IKKα controls prostate cancer metastasis by repressing Maspin
Jun-Li Luo, Wei Tan, Jill M. Ricono, Olexandr Korchynskyi, Ming Zhang, Steven L. Gonias, David A. Cheresh & Michael Karin Nature446, 690–694
(5 April 2007); doi:10.1038/nature05656
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article Rab27a regulates phagosomal pH and NADPH oxidase recruitment to dendritic cell phagosomes
Carolina Jancic, Ariel Savina, Christina Wasmeier, Tanya Tolmachova, Jamel El-Benna, Pham My-Chan Dang, Steve Pascolo, Maire-Anne Gougerot-Pocidalo, Graça Raposo, Miguel C. Seabra & Sebastian Amigorena Nature Cell Biology9, 367–378
(April 2007); doi:10.1038/ncb1552
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news and views New ways to arrest phagosome maturation
David G. Russell Nature Cell Biology9, 357–359
(April 2007); doi:10.1038/ncb0407-357
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letter α4 Integrins are Type I cAMP-dependent protein kinase-anchoring proteins
Chinten James Lim, Jaewon Han, Nima Yousefi, Yuliang Ma, Paul S. Amieux, G. Stanley McKnight, Susan S. Taylor & Mark H. Ginsberg Nature Cell Biology9, 415–421
(April 2007); doi:10.1038/ncb1561
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news and views Rapid cargo shuttling by caveolae
Christina Karlsson Rosenthal Nature Cell Biology9, 366–366
(April 2007); doi:10.1038/ncb0407-366
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perspective Helping Wingless take flight: how WNT proteins are secreted
George Hausmann, Carla Bänziger & Konrad Basler Nature Reveiws Molecular Cell Biology8, 331–336
(April 2007); doi:10.1038/nrm2141
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article Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor
Lu Deng, Ries J Langley, Patrick H Brown, Gang Xu, Leslie Teng, Qian Wang, Monica I Gonzales, Glenda G Callender, Michael I Nishimura, Suzanne L Topalian & Roy A Mariuzza Nature Immunology8, 398–408
(April 2007); doi:10.1038/ni1447
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review Whatever turns you on: accessory-cell-dependent activation of NK cells by pathogens
Kirsty C. Newman & Eleanor M. Riley Nature Reviews Immunology7, 279–291
(April 2007); doi:10.1038/nri2057
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review Hyperactive Ras in developmental disorders and cancer
Suzanne Schubbert, Kevin Shannon & Gideon Bollag Nature Reviews Cancer7, 295–308
(April 2007); doi:10.1038/nrc2109
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perspective Shaping the future of biomarker research in breast cancer to ensure clinical relevance
M. Carolina Hinestrosa, Kay Dickersin, Pamela Klein, Musa Mayer, Karin Noss, Dennis Slamon, George Sledge & Frances M. Visco Nature Reviews Cancer7, 309–315
(April 2007); doi:10.1038/nrc2113
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article Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogaster
James Jiayuan Tong, Samuel E Schriner, David McCleary, Brian J Day & Douglas C Wallace Nature Genetics39, 476–485
(April 2007); doi:10.1038/ng2004
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article Activity-dependent AIDA-1 nuclear signaling regulates nucleolar numbers and protein synthesis in neurons
Bryen A Jordan, Brian D Fernholz, Latika Khatri & Edward B Ziff Nature Neuroscience10, 427–435
(April 2007); doi:10.1038/nn1867
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news and views Synapses go nucle(ol)ar
Joel D Richter & Justin R Fallon Nature Neuroscience10, 399–400
(April 2007); doi:10.1038/nn0407-399
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perspective Stratified medicine: strategic and economic implications of combining drugs and clinical biomarkers
Mark R. Trusheim, Ernst R. Berndt & Frank L. Douglas Nature Reviews Drug Discovery6, 287–293
(April 2007); doi:10.1038/nrd2251
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article Unitary permeability of gap junction channels to second messengers measured by FRET microscopy
Victor H Hernandez, Mario Bortolozzi, Vanessa Pertegato, Martina Beltramello, Michele Giarin, Manuela Zaccolo, Sergio Pantano & Fabio Mammano Nature Methods4, 353–358
(April 2007); doi:10.1038/nmeth1031
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news and views Focal adhesion: getting a grasp on myxobacterial gliding
Wenyuan Shi and Renate Lux Nature Chemical Biology3, 205–206
(April 2007); doi:10.1038/nchembio0407-205
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