The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.
Click here for free access to the 'Featured Articles' section, with new articles every week.
article 'Rejuvenation' protects neurons in mouse models of Parkinson's disease
C. Savio Chan, Jaime N. Guzman, Ema Ilijic, Jeff N. Mercer, Caroline Rick, Tatiana Tkatch, Gloria E. Meredith & D. James Surmeier Nature447, 1081–1086
(28 June 2007); doi:10.1038/nature05865
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article Genome-wide association study identifies novel breast cancer susceptibility loci
Douglas F. Easton, et al. Nature447, 1087–1093
(28 June 2007); doi:10.1038/nature05887
| Summary | Full Text (HTML / PDF) |
letter Macrophage-specific PPAR γ controls alternative activation and improves insulin resistance
Justin I. Odegaard, Roberto R. Ricardo-Gonzalez, Matthew H. Goforth, Christine R. Morel, Vidya Subramanian, Lata Mukundan, Alex Red Eagle, Divya Vats, Frank Brombacher, Anthony W. Ferrante & Ajay Chawla Nature447, 1116–1120
(28 June 2007); doi:10.1038/nature05894
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letter Ambra1 regulates autophagy and development of the nervous system
Gian Maria Fimia, Anastassia Stoykova, Alessandra Romagnoli, Luigi Giunta, Sabrina Di Bartolomeo, Roberta Nardacci, Marco Corazzari, Claudia Fuoco, Ahmet Ucar, Peter Schwartz, Peter Gruss, Mauro Piacentini, Kamal Chowdhury & Francesco Cecconi Nature447, 1121–1125
(28 June 2007); doi:10.1038/nature05925
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letter A microRNA component of the p53 tumour suppressor network
Lin He, Xingyue He, Lee P. Lim, Elisa de Stanchina, Zhenyu Xuan, Yu Liang, Wen Xue, Lars Zender, Jill Magnus, Dana Ridzon, Aimee L. Jackson, Peter S. Linsley, Caifu Chen, Scott W. Lowe, Michele A. Cleary & Gregory J. Hannon Nature447, 1130–1134
(28 June 2007); doi:10.1038/nature05939
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letter Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging
Jianping Jin, Xue Li, Steven P. Gygi & J. Wade Harper Nature447, 1135–1138
(28 June 2007); doi:10.1038/nature05902
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letter Rad3-dependent phosphorylation of the checkpoint clamp regulates repair-pathway choice
Mihoko Kai, Kanji Furuya, Francesca Paderi, Antony M. Carr & Teresa S.F. Wang Nature Cell Biology9, 691–697
(June 2007); doi:10.1038/ncb1600
| Summary | Full Text (HTML / PDF) |
review Stressing the role of FoxO proteins in lifespan and disease
Armando van der Horst & Boudewijn M.T. Burgering Nature Reviews Molecular Cell Biology8, 440–450
(June 2007); doi:10.1038/nrm2190
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review Centrosome biogenesis and function: centrosomics brings new understanding
Mónica Bettencourt-Dias & David M. Glover Nature Reviews Molecular Cell Biology8, 451–463
(June 2007); doi:10.1038/nrm2180
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article Activation of the lectin DC-SIGN induces an immature dendritic cell phenotype triggering Rho-GTPase activity required for HIV-1 replication
Ashleigh Hodges, Katherine Sharrocks, Mariola Edelmann, Dilair Baban, Arnaud Moris, Olivier Schwartz, Hal Drakesmith, Kay Davies, Benedikt Kessler, Andrew McMichael & Alison Simmons Nature Immunology8, 569–577
(June 2007); doi:10.1038/ni1470
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news and views DC-SIGN 'AIDS' HIV immune evasion and infection
Anthony L Cunningham, Andrew N Harman & Heather Donaghy Nature Immunology8, 556–558
(June 2007); doi:10.1038/ni0607-556
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article Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17
Salomé LeibundGut-Landmann, Olaf Grosß, Matthew J Robinson, Fabiola Osorio, Emma C Slack, S Vicky Tsoni, Edina Schweighoffer, Victor Tybulewicz, Gordon D Brown, Jürgen Ruland & Caetano Reis e Sousa Nature Immunology8, 630–638
(June 2007); doi:10.1038/ni1460
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review TGFβ signalling in control of T-cell-mediated self-reactivity
Yuri P Rubtsov & Alexander Y Rudensky Nature Reviews Immunology7, 443–453
(June 2007); doi:10.1038/nri2095
| Summary | Full Text (HTML / PDF) |
perspective Signalling through TEC kinases regulates conventional versus innate CD8+ T-cell development
Leslie J. Berg Nature Reviews Immunology7, 479–453
(June 2007); doi:10.1038/nri2091
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article TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1
Ahjoku Amadi-Obi, Cheng-Rong Yu, Xuebin Liu, Rashid M Mahdi, Grace Levy Clarke, Robert B Nussenblatt, Igal Gery, Yun Sang Lee & Charles E Egwuagu Nature Medicine13, 711–718
(June 2007); doi:10.1038/nm1585
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letter Abrogation of nuclear receptors Nr4a3 andNr4a1 leads to development of acute myeloid leukemia
Shannon E Mullican, Shuo Zhang, Marina Konopleva, Vivian Ruvolo, Michael Andreeff, Jeffrey Milbrandt & Orla M Conneely Nature Medicine13, 730–735
(June 2007); doi:10.1038/nm1579
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letter Targeting calcineurin activation as a therapeutic strategy for T-cell acute lymphoblastic leukemia
Hind Medyouf, Hélène Alcalde, Caroline Berthier, Marie Claude Guillemin, Nuno R dos Santos, Anne Janin, Didier Decaudin, Hugues de Thé & Jacques Ghysdael Nature Medicine13, 736–741
(June 2007); doi:10.1038/nm1588
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news and views Linking calcineurin activity to leukemogenesis
Martin R Müller & Anjana Rao Nature Medicine13, 669–671
(June 2007); doi:10.1038/nm0607-669
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review Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
Héctor Peinado, David Olmeda & Amparo Cano Nature Reviews Cancer7, 415–428
(June 2007); doi:10.1038/nrc2131
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review Chronic myeloid leukaemia as a model of disease evolution in human cancer
Junia V. Melo & David J. Barnes Nature Reviews Cancer7, 441–453
(June 2007); doi:10.1038/nrc2147
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article MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer
Vassiliki Theodorou, Melanie A Kimm, Mandy Boer, Lodewyk Wessels, Wendy Theelen, Jos Jonkers & John Hilkens Nature Genetics39, 759–769
(June 2007); doi:10.1038/ng2034
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review Exploring genetic interactions and networks with yeast
Charles Boone, Howard Bussey & Brenda J. Andrews Nature Reviews Genetics8, 437–449
(June 2007); doi:10.1038/nrg2085
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article BDNF induces transport of PSD-95 to dendrites through PI3K-AKT signaling after NMDA receptor activation
Akira Yoshii & Martha Constantine-Paton Nature Neuroscience10, 702–711
(June 2007); doi:10.1038/nn1903
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article Identification of a lectin causing the degeneration of neuronal processes using engineered embryonic stem cells
Nicolas Plachta, Christine Annaheim, Stephanie Bissière, Shuo Lin, Markus Rüegg, Sjouke Hoving, Dieter Müller, Françoise Poirier, Miriam Bibel & Yves-Alain Barde Nature Neuroscience10, 712–719
(June 2007); doi:10.1038/nn1897
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review Cell-cycle control and cortical development
Colette Dehay & Henry Kennedy Nature Reviews Neuroscience8, 438–450
(June 2007); doi:10.1038/nrn2097
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article Genome-scale analysis of in vivo spatiotemporal promoter activity in Caenorhabditis elegans
Denis Dupuy, Nicolas Bertin, César A Hidalgo, Kavitha Venkatesan, Domena Tu, David Lee, Jennifer Rosenberg, Nenad Svrzikapa, Aurélie Blanc, Alain Carnec, Anne-Ruxandra Carvunis, Rock Pulak, Jane Shingles, John Reece-Hoyes, Rebecca Hunt-Newbury, Ryan Viveiros, William A Mohler, Murat Tasan, Frederick P Roth, Christian Le Peuch, Ian A Hope, Robert Johnsen, Donald G Moerman, Albert-László Barabási, David Baillie & Marc Vidal Nature Biotechnology25, 663–668
(June 2007); doi:10.1038/nbt1305
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news and views A green light to expression in time and space
Susan E Mango Nature Biotechnology25, 645–646
(June 2007); doi:10.1038/nbt0607-645
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article Competitive binding of AUF1 and TIAR to MYC mRNA controls its translation
Baisong Liao, Yan Hu & Gary Brewer Nature Structural & Molecular Biology14, 511–518
(June 2007); doi:10.1038/nsmb1249
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article Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40
Yu Chen, Yanhui Xu, Qing Bao, Yongna Xing, Zhu Li, Zheng Lin, Jeffry B Stock, Philip D Jeffrey & Yigong Shi Nature Structural & Molecular Biology14, 527–534
(June 2007); doi:10.1038/nsmb1254
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article Swi3p controls SWI/SNF assembly and ATP-dependent H2A-H2B displacement
Xiaofang Yang, Roser Zaurin, Miguel Beato & Craig L Peterson Nature Structural & Molecular Biology14, 540–547
(June 2007); doi:10.1038/nsmb1238
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review The unique role of natural killer T cells in the response to microorganisms
Emmanuel Tupin, Yuki Kinjo & Mitchell Kronenberg Nature Reviews Microbiology5, 405–417
(June 2007); doi:10.1038/nrmicro1657
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article A semisynthetic epitope for kinase substrates
Jasmina J Allen, Manqing Li, Craig S Brinkworth, Jennifer L Paulson, Dan Wang, Anette Hübner, Wen-Hai Chou, Roger J Davis, Alma L Burlingame, Robert O Messing, Carol D Katayama, Stephen M Hedrick & Kevan M Shokat Nature Methods4, 511–516
(June 2007); doi:10.1038/nmeth1048
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scientific report Structural plasticity in the oestrogen receptor ligand-binding domain
Kendall W Nettles, John B Bruning, German Gil, Erin E O'Neill, Jason Nowak, Alun Hughs, Younchang Kim, Eugene R DeSombre, Robert Dilis, Robert N Hanson, Andrzej Joachimiak & Geoffrey L Greene EMBO Reports8, 563–568
(June 2007); doi:10.1038/sj.embor.7400963
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scientific report Structural insights into a new homodimeric self-activated GTPase family
Stéphanie Gras, Valérie Chaumont, Bernard Fernandez, Philippe Carpentier, Fabienne Charrier-Savournin, Sophie Schmitt, Charles Pineau, Didier Flament, Arnaud Hecker, Patrick Forterre, Jean Armengaud & Dominique Housset EMBO Reports8, 569–575
(June 2007); doi:10.1038/sj.embor.7400958
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scientific report Transport of the leaderless protein Ku on the cell surface of activated monocytes regulates their migratory abilities
Jenny Paupert, Stéphanie Dauvillier, Bernard Salles & Catherine Muller EMBO Reports8, 583–588
(June 2007); doi:10.1038/sj.embor.7400976
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letter Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis
Trista E. North, Wolfram Goessling, Carl R. Walkley, Claudia Lengerke, Kamden R. Kopani, Allegra M. Lord, Gerhard J. Weber, Teresa V. Bowman, Il-Ho Jang, Tilo Grosser, Garret A. FitzGerald, George Q. Daley, Stuart H. Orkin & Leonard I. Zon Nature447, 1007–1011
(21 June 2007); doi:10.1038/nature05883
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letter Energy-dependent regulation of cell structure by AMP-activated protein kinase
Jun Hee Lee, Hyongjong Koh, Myungjin Kim, Yongsung Kim, Soo Young Lee, Roger E. Karess, Sang-Hee Lee, Minho Shong, Jin-Man Kim, Jaeseob Kim & Jongkyeong Chung Nature447, 1017–1025
(21 June 2007); doi:10.1038/nature05828
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article Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2
Masato Furuhashi, Gürol Tuncman, Cem Z. Görgün, Liza Makowski, Genichi Atsumi, Eric Vaillancourt, Keita Kono, Vladimir R. Babaev, Sergio Fazio, MacRae F. Linton, Richard Sulsky, Jeffrey A. Robl, Rex A. Parker & Gökhan S. Hotamisligil Nature447, 959–965
(21 June 2007); doi:10.1038/nature05844
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article Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers
Richard S. Maser, Bhudipa Choudhury, Peter J. Campbell, Bin Feng, Kwok-Kin Wong, Alexei Protopopov, Jennifer O'Neil, Alejandro Gutierrez, Elena Ivanova, Ilana Perna, Eric Lin, Vidya Mani, Shan Jiang, Kate McNamara, Sara Zaghlul, Sarah Edkins, Claire Stevens, Cameron Brennan, Eric S. Martin, Ruprecht Wiedemeyer, Omar Kabbarah, Cristina Nogueira, Gavin Histen, Jon Aster, Marc Mansour, Veronique Duke, Letizia Foroni, Adele K. Fielding, Anthony H. Goldstone, Jacob M. Rowe, Yaoqi A. Wang, A. Thomas Look, Michael R. Stratton, Lynda Chin, P. Andrew Futreal & Ronald A. DePinho Nature447, 966–971
(21 June 2007); doi:10.1038/nature05886
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article Gene-specific control of inflammation by TLR-induced chromatin modifications
Simmie L. Foster, Diana C. Hargreaves & Ruslan Medzhitov Nature447, 972–978
(21 June 2007); doi:10.1038/nature05836
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news and views Immunology: Short-term memory
Benjamin N. Gantner & Harinder Singh Nature447, 916–917
(21 June 2007); doi:10.1038/447916a
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letter Mechanism of coupled folding and binding of an intrinsically disordered protein
Kenji Sugase, H. Jane Dyson & Peter E. Wright Nature447, 1021–1025
(21 June 2007); doi:10.1038/nature05858
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news and views Biophysics: Proteins hunt and gather
David Eliezer & Arthur G. Palmer, III Nature447, 920–921
(21 June 2007); doi:10.1038/447920a
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letter Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair
Elijahu Berkovich, Raymond J. Monnat Jr. & Michael B. Kastan Nature Cell Biology9, 683–690
(June 2007); doi:10.1038/ncb1599
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review Inheritance and biogenesis of organelles in the secretory pathway
Martin Lowe & Francis A. Barr Nature Reviews Molecular Cell Biology8, 429–439
(June 2007); doi:10.1038/nrm2179
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article Cell surface 4-1BBL mediates sequential signaling pathways 'downstream' of TLR and is required for sustained TNF production in macrophages
Young Jun Kang, Sung Ouk Kim, Shigeki Shimada, Motoyuki Otsuka, Alim Seit-Nebi, Byoung S Kwon, Tania H Watts & Jiahuai Han Nature Immunology8, 601–609
(June 2007); doi:10.1038/ni1471
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article Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages
Sushil Kumar Pathak, Sanchita Basu, Kunal Kumar Basu, Anirban Banerjee, Shresh Pathak, Asima Bhattacharyya, Tsuneyasu Kaisho, Manikuntala Kundu & Joyoti Basu Nature Immunology8, 610–618
(June 2007); doi:10.1038/ni1468
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review Cytokines in the pathogenesis of rheumatoid arthritis
Iain B. McInnes & Georg Schett Nature Reviews Immunology7, 429–442
(June 2007); doi:10.1038/nri2094
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article Retinaldehyde represses adipogenesis and diet-induced obesity
Ouliana Ziouzenkova, Gabriela Orasanu, Molly Sharlach, Taro E Akiyama, Joel P Berger, Jason Viereck, James A Hamilton, Guangwen Tang, Gregory G Dolnikowski, Silke Vogel, Gregg Duester & Jorge Plutzky Nature Medicine13, 695–702
(June 2007); doi:10.1038/nm1587
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news and views Retinaldehyde: more than meets the eye
Béatrice Desvergne Nature Medicine13, 671–673
(June 2007); doi:10.1038/nm0607-671
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letter Mast cells promote atherosclerosis by releasing proinflammatory cytokines
Jiusong Sun, Galina K Sukhova, Paul J Wolters, Min Yang, Shiro Kitamoto, Peter Libby, Lindsey A MacFarlane, Jon Mallen-St Clair & Guo-Ping Shi Nature Medicine13, 719–724
(June 2007); doi:10.1038/nm1601
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news and views HER3 and mutant EGFR meet MET
Carlos L Arteaga Nature Medicine13, 675–677
(June 2007); doi:10.1038/nm0607-675
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review The cofilin pathway in breast cancer invasion and metastasis
Weigang Wang, Robert Eddy & John Condeelis Nature Reviews Cancer7, 429–440
(June 2007); doi:10.1038/nrc2148
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brief communication Tissue-specific transcriptional regulation has diverged significantly between human and mouse
Duncan T Odom, Robin D Dowell, Elizabeth S Jacobsen, William Gordon, Timothy W Danford, Kenzie D MacIsaac, P Alexander Rolfe, Caitlin M Conboy, David K Gifford & Ernest Fraenkel Nature Genetics39, 730–732
(June 2007); doi:10.1038/ng2047
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review Spindle orientation, asymmetric division and tumour suppression in Drosophila stem cells
Cayetano Gonzalez Nature Reviews Genetics8, 462–472
(June 2007); doi:10.1038/nrg2103
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brief communication Environmental enrichment in adulthood promotes amblyopia recovery through a reduction of intracortical inhibition
Alessandro Sale, José Fernando Maya Vetencourt, Paolo Medini, Maria Cristina Cenni, Laura Baroncelli, Roberto De Pasquale & Lamberto Maffei Nature Neuroscience10, 679–681
(June 2007); doi:10.1038/nn1899
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review NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders
C. Geoffrey Lau & R. Suzanne Zukin Nature Reviews Neuroscience8, 413–426
(June 2007); doi:10.1038/nrn2153
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brief communication Engineering synthetic signaling proteins with ultrasensitive input/output control
John E Dueber, Ethan A Mirsky & Wendell A Lim Nature Biotechnology25, 660–662
(June 2007); doi:10.1038/nbt1308
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news and views Membrane proteins up for grabs
Gunnar von Heijne Nature Biotechnology25, 646–647
(June 2007); doi:10.1038/nbt0607-646
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review Microenvironmental regulation of biomacromolecular therapies
Hyun Joon Kong & David J. Mooney Nature Reviews Drug Discovery6, 455–463
(June 2007); doi:10.1038/nrd2309
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article Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK
Yoshihiro Kobashigawa, Mieko Sakai, Masato Naito, Masashi Yokochi, Hiroyuki Kumeta, Yoshinori Makino, Kenji Ogura, Shinya Tanaka & Fuyuhiko Inagaki Nature Structural & Molecular Biology14, 503–510
(June 2007); doi:10.1038/nsmb1241
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news and views Moving parts: how the adaptor protein CRK is regulated, and regulates
David Cowburn Nature Structural & Molecular Biology14, 465–466
(June 2007); doi:10.1038/nsmb0607-465
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article The redox-switch domain of Hsp33 functions as dual stress sensor
Marianne Ilbert, Janina Horst, Sebastian Ahrens, Jeannette Winter, Paul C F Graf, Hauke Lilie & Ursula Jakob Nature Structural & Molecular Biology14, 556–563
(June 2007); doi:10.1038/nsmb1244
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brief communication FANCI is a second monoubiquitinated member of the Fanconi anemia pathway
Ashley E Sims, Elizabeth Spiteri, Robert J Sims III, Adriana G Arita, Francis P Lach, Thomas Landers, Melanie Wurm, Marcel Freund, Kornelia Neveling, Helmut Hanenberg, Arleen D Auerbach & Tony T Huang Nature Structural & Molecular Biology14, 564–567
(June 2007); doi:10.1038/nsmb1252
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article Generation of functional hemangioblasts from human embryonic stem cells
Shi-Jiang Lu, Qiang Feng, Sergio Caballero, Yu Chen, Malcolm A S Moore, Maria B Grant & Robert Lanzaamp; Nature Methods4, 501–509
(June 2007); doi:10.1038/nmeth1041
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letter Chemical sensing of DNT by engineered olfactory yeast strain
Venkat Radhika, Tassula Proikas-Cezanne, Muralidharan Jayaraman, Djamila Onesime, Ji Hee Ha & Danny N Dhanasekaran Nature Chemical Biology3, 325–330
(June 2007); doi:10.1038/nchembio882
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news and views Smells like bread
David R Walt Nature Chemical Biology3, 306–307
(June 2007); doi:10.1038/nchembio0607-306
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article MicroRNA silencing through RISC recruitment of eIF6
Thimmaiah P. Chendrimada, Kenneth J. Finn, Xinjun Ji, David Baillat, Richard I. Gregory, Stephen A. Liebhaber, Amy E. Pasquinelli & Ramin Shiekhattar Nature447, 823–828
(14 June 2007); doi:10.1038/nature05841
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article Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
The ENCODE Project Consortium Analysis Coordination Chromatin and Replication Genes and Transcripts Integrated Analysis and Manuscript Preparation Management Group Multi-species Sequence Analysis Transcriptional Regulatory Elements UCSC Genome Browser Variation NISC Comparative Sequencing Program Baylor College of Medicine, Human Genome Sequencing Center Washington University Genome Sequencing Center Broad Institute Children's Hospital Oakland Research Institute Nature447, 799–816
(14 June 2007); doi:10.1038/nature05874
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article Exploitation of structural and regulatory diversity in glutamate racemases
Tomas Lundqvist, Stewart L. Fisher, Gunther Kern, Rutger H. A. Folmer, Yafeng Xue, D. Trevor Newton, Thomas A. Keating, Richard A. Alm & Boudewijn L. M. de Jonge Nature447, 817–822
(14 June 2007); doi:10.1038/nature05689
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letter Sensory neuron sodium channel Nav1.8 is essential for pain at low temperatures
Katharina Zimmermann, Andreas Leffler, Alexandru Babes, Cruz Miguel Cendan, Richard W. Carr, Jin-ichi Kobayashi, Carla Nau, John N. Wood & Peter W. Reeh Nature447, 856–859
(14 June 2007); doi:10.1038/nature05880
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letter HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS
Udai Bhan Pandey, Zhiping Nie, Yakup Batlevi, Brett A. McCray, Gillian P. Ritson, Natalia B. Nedelsky, Stephanie L. Schwartz, Nicholas A. DiProspero, Melanie A. Knight, Oren Schuldiner, Ranjani Padmanabhan, Marc Hild, Deborah L. Berry, Dan Garza, Charlotte C. Hubbert, Tso-Pang Yao, Eric H. Baehrecke & J. Paul Taylor Nature447, 860–864
(14 June 2007); doi:10.1038/nature05853
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letter RAS–RAF–MEK-dependent oxidative cell death involving voltage-dependent anion channels
Nicholas Yagoda, Moritz von Rechenberg, Elma Zaganjor, Andras J. Bauer, Wan Seok Yang, Daniel J. Fridman, Adam J. Wolpaw, Inese Smukste, John M. Peltier, J. Jay Boniface, Richard Smith, Stephen L. Lessnick, Sudhir Sahasrabudhe & Brent R. Stockwell Nature447, 865–869
(14 June 2007); doi:10.1038/nature05859
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letter Resolvin E1 and protectin D1 activate inflammation-resolution programmes
Jan M. Schwab, Nan Chiang, Makoto Arita & Charles N. Serhan Nature447, 869–874
(14 June 2007); doi:10.1038/nature05877
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letter Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation
Rolf Thermann & Matthias W. Hentze Nature447, 875–878
(14 June 2007); doi:10.1038/nature05878
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article STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels
Joseph P. Yuan, Weizhong Zeng, Guo N. Huang, Paul F. Worley & Shmuel Muallem Nature Cell Biology9, 636–645
(June 2007); doi:10.1038/ncb1590
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letter Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
Hadi Valadi, Karin Ekström, Apostolos Bossios, Margareta Sjöstrand, James J Lee & Jan O Lötvall Nature Cell Biology9, 654–659
(June 2007); doi:10.1038/ncb1596
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letter Caspase-14 protects against epidermal UVB photodamage and water loss
Geertrui Denecker, Esther Hoste, Barbara Gilbert, Tino Hochepied, Petra Ovaere, Saskia Lippens, Caroline Van den Broecke, Petra Van Damme, Katharina D'Herde, Jean-Pierre Hachem, Gaetan Borgonie, Richard B. Presland, Luc Schoonjans, Claude Libert, Joël Vandekerckhove, Kris Gevaert, Peter Vandenabeele & Wim Declercq Nature Cell Biology9, 666–674
(June 2007); doi:10.1038/ncb1597
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news and views Caspase-14 and epidermis maturation
Pierluigi Nicotera & Gerry Melino Nature Cell Biology9, 621–622
(June 2007); doi:10.1038/ncb0607-621
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review Molecular regulation of angiogenesis and lymphangiogenesis
Ralf H. Adams & Kari Alitalo Nature Reviews Molecular Cell Biology8, 464–478
(June 2007); doi:10.1038/nrm2183
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article The NEMO adaptor bridges the nuclear factor-κB and interferon regulatory factor signaling pathways
Tiejun Zhao, Long Yang, Qiang Sun, Meztli Arguello, Dean W Ballard, John Hiscott & Rongtuan Lin Nature Immunology8, 592–600
(June 2007); doi:10.1038/ni1465
| Summary | Full Text (HTML / PDF) |
perspective Signalling through TEC kinases regulates conventional versus innate CD8+ T-cell development
Leslie J. Berg Nature Reviews Immunology7, 479–485
(June 2007); doi:10.1038/nri2091
| Summary | Full Text (HTML / PDF) |
progress TH1 cells control themselves by producing interleukin-10
Anne O'Garra & Paulo Vieira Nature Reviews Immunology7, 425–428
(June 2007); doi:10.1038/nri2097
| Summary | Full Text (HTML / PDF) |
letter Neutralization of staphylococcal enterotoxin B by soluble, high-affinity receptor antagonists
Rebecca A Buonpane, Hywyn R O Churchill, Beenu Moza, Eric J Sundberg, Marnie L Peterson, Patrick M Schlievert & David M Kranz Nature Medicine13, 725–729
(June 2007); doi:10.1038/nm1584
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technical report The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas
Eva Hernando, Elizabeth Charytonowicz, Maria E Dudas, Silvia Menendez, Igor Matushansky, Joslyn Mills, Nicholas D Socci, Nille Behrendt, Li Ma, Robert G Maki, Pier Paolo Pandolfi & Carlos Cordon-Cardo Nature Medicine13, 748–753
(June 2007); doi:10.1038/nm1560
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brief communication Restoration of cone vision in a mouse model of achromatopsia
John J Alexander, Yumiko Umino, Drew Everhart, Bo Chang, Seok H Min, Qiuhong Li, Adrian M Timmers, Norman L Hawes, Ji-jing Pang, Robert B Barlow & William W Hauswirth Nature Medicine13, 685–687
(June 2007); doi:10.1038/nm1596
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progress Changing venues for tumour suppression: balancing destruction and localization by monoubiquitylation
Leonardo Salmena & Pier Paolo Pandolfi Nature Reviews Cancer7, 409–413
(June 2007); doi:10.1038/nrc2145
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letter Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion
Alice Bourdon, Limor Minai, Valérie Serre, Jean-Philippe Jais, Emmanuelle Sarzi, Sophie Aubert, Dominique Chrétien, Pascale de Lonlay, Véronique Paquis-Flucklinger, Hirofumi Arakawa, Yusuke Nakamura, Arnold Munnich & Agnès Rötig Nature Genetics39, 776–780
(June 2007); doi:10.1038/ng2040
| Summary | Full Text (HTML / PDF) |
news and views Ribonucleotide reductase and mitochondrial DNA synthesis
Lars Thelander Nature Genetics39, 703–704
(June 2007); doi:10.1038/ng0607-703
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article RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels
Shigeki Kiyonaka, Minoru Wakamori, Takafumi Miki, Yoshitsugu Uriu, Mio Nonaka, Haruhiko Bito, Aaron M Beedle, Emiko Mori, Yuji Hara, Michel De Waard, Motoi Kanagawa, Makoto Itakura, Masami Takahashi, Kevin P Campbell & Yasuo Mori Nature Neuroscience10, 691–701
(June 2007); doi:10.1038/nn1904
| Summary | Full Text (HTML / PDF) |
review The action potential in mammalian central neurons
Bruce P. Bean Nature Reviews Neuroscience8, 451–465
(June 2007); doi:10.1038/nrn2148
| Summary | Full Text (HTML / PDF) |
letter Decoding global gene expression programs in liver cancer by noninvasive imaging
Eran Segal, Claude B Sirlin, Clara Ooi, Adam S Adler, Jeremy Gollub, Xin Chen, Bryan K Chan, George R Matcuk, Christopher T Barry, Howard Y Chang & Michael D Kuo Nature Biotechnology25, 675–680
(June 2007); doi:10.1038/nbt1306
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letter A ROCK inhibitor permits survival of dissociated human embryonic stem cells
Kiichi Watanabe, Morio Ueno, Daisuke Kamiya, Ayaka Nishiyama, Michiru Matsumura, Takafumi Wataya, Jun B Takahashi, Satomi Nishikawa, Shin-ichi Nishikawa, Keiko Muguruma & Yoshiki Sasai Nature Biotechnology25, 681–686
(June 2007); doi:10.1038/nbt1310
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progress Interfering with disease: a progress report on siRNA-based therapeutics
Antonin de Fougerolles, Hans-Peter Vornlocher, John Maraganore & Judy Lieberman Nature Reviews Drug Discovery6, 443–453
(June 2007); doi:10.1038/nrd2310
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article The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization
Thomas Schwarz-Romond, Marc Fiedler, Naoki Shibata, P Jonathan G Butler, Akira Kikuchi, Yoshiki Higuchi & Mariann Bienz Nature Structural & Molecular Biology14, 484–492
(June 2007); doi:10.1038/nsmb1247
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news and views It takes more than two to tango: Dishevelled polymerization and Wnt signaling
David M Roberts, Kevin C Slep & Mark Peifer Nature Structural & Molecular Biology14, 463–465
(June 2007); doi:10.1038/nsmb0607-463
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article SET and PARP1 remove DEK from chromatin to permit access by the transcription machinery
Matthew J Gamble & Robert P Fisher Nature Structural & Molecular Biology14, 548–555
(June 2007); doi:10.1038/nsmb1248
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review Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections
William J. Steinbach, Jennifer L. Reedy, Robert A. Cramer, Jr, John R. Perfect & Joseph Heitman Nature Reviews Microbiology5, 418–430
(June 2007); doi:10.1038/nrmicro1680
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brief communication Pervasive combinatorial modification of histone H3 in human cells
Benjamin A Garcia, James J Pesavento, Craig A Mizzen & Neil L Kelleher Nature Methods4, 487–489
(June 2007); doi:10.1038/nmeth1052
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brief communication Microgram-scale protein structure determination by NMR
James M Aramini, Paolo Rossi, Clemens Anklin, Rong Xiao & Gaetano T Montelione Nature Methods4, 491–493
(June 2007); doi:10.1038/nmeth1051
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article Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium Nature447, 661–678
(7 June 2007); doi:10.1038/nature05911
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news and views Genomics: Guilt by association
Anne M. Bowcock Nature447, 645–646
(7 June 2007); doi:10.1038/447645a
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article DNA repair is limiting for haematopoietic stem cells during ageing
Anastasia Nijnik, Lisa Woodbine, Caterina Marchetti, Sara Dawson, Teresa Lambe, Cong Liu, Neil P. Rodrigues, Tanya L. Crockford, Erik Cabuy, Alessandro Vindigni, Tariq Enver, John I. Bell, Predrag Slijepcevic, Christopher C. Goodnow, Penelope A. Jeggo & Richard J. Cornall Nature447, 686–690
(7 June 2007); doi:10.1038/nature05875
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letter Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
Derrick J. Rossi, David Bryder, Jun Seita, Andre Nussenzweig, Jan Hoeijmakers & Irving L. Weissman Nature447, 725–729
(7 June 2007); doi:10.1038/nature05862
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letter Dscam2 mediates axonal tiling in the Drosophila visual system
S. Sean Millard, John J. Flanagan, Kartik S. Pappu, Wei Wu & S. Lawrence Zipursky Nature447, 720–724
(7 June 2007); doi:10.1038/nature05855
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letter The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks
Michael Kruhlak, Elizabeth E. Crouch, Marika Orlov, Carolina Montaño, Stanislaw A. Gorski, André Nussenzweig, Tom Misteli, Robert D. Phair & Rafael Casellas Nature447, 730–734
(7 June 2007); doi:10.1038/nature05842
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letter Control of DNA methylation and heterochromatic silencing by histone H2B deubiquitination
Vaniyambadi V. Sridhar, Avnish Kapoor, Kangling Zhang, Jianjun Zhu, Tao Zhou, Paul M. Hasegawa, Ray A. Bressan & Jian-Kang Zhu Nature447, 735–738
(7 June 2007); doi:10.1038/nature05864
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article Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells
Shinji Masui, Yuhki Nakatake, Yayoi Toyooka, Daisuke Shimosato, Rika Yagi, Kazue Takahashi, Hitoshi Okochi, Akihiko Okuda, Ryo Matoba, Alexei A. Sharov, Minoru S. H. Ko & Hitoshi Niwa Nature Cell Biology9, 625–635
(June 2007); doi:10.1038/ncb1589
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letter p73 supports cellular growth through c-Jun-dependent AP-1 transactivation
Faina Vikhanskaya, Wen Hong Toh, Iqbal Dulloo, Qiang Wu, Lakshmanane Boominathan, Huck Hui Ng, Karen H. Vousden & Kanaga Sabapathy Nature Cell Biology9, 698–706
(June 2007); doi:10.1038/ncb1598
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article PDLIM2-mediated termination of transcription factor NF-κB activation by intranuclear sequestration and degradation of the p65 subunit
Takashi Tanaka, Michael J Grusby & Tsuneyasu Kaisho Nature Immunology8, 584–591
(June 2007); doi:10.1038/ni1464
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review Morphogens, morphostats, microarchitecture and malignancy
John D. Potter Nature Reviews Cancer7, 464–474
(June 2007); doi:10.1038/nrc2146
| Summary | Full Text (HTML / PDF) |
perspective Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition
Henk M. W. Verheul & Herbert M. Pinedo Nature Reviews Cancer7, 475–485
(June 2007); doi:10.1038/nrc2152
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article p38α suppresses normal and cancer cell proliferation by antagonizing the JNK–c-Jun pathway
Lijian Hui, Latifa Bakiri, Andreas Mairhorfer, Norbert Schweifer, Christian Haslinger, Lukas Kenner, Vukoslav Komnenovic, Harald Scheuch, Hartmut Beug & Erwin F Wagner Nature Genetics39, 741–749
(June 2007); doi:10.1038/ng2033
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article p38α MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation
Juan José Ventura, Stephan Tenbaum, Eusebio Perdiguero, Marion Huth, Carmen Guerra, Mariano Barbacid, Manolis Pasparakis & Angel R Nebreda Nature Genetics39, 750–758
(June 2007); doi:10.1038/ng2037
| Summary | Full Text (HTML / PDF) |
article Multiple climbing fibers signal to molecular layer interneurons exclusively via glutamate spillover
Germán Szapiro & Boris Barbour Nature Neuroscience10, 735–742
(June 2007); doi:10.1038/nn1907
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review Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases
Jialiang Hu, Philippe E. Van den Steen, Qing-Xiang A. Sang & Ghislain Opdenakker Nature Reviews Drug Discovery6, 480–498
(June 2007); doi:10.1038/nrd2308
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article Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2
Fumiko Esashi, Vitold E Galkin, Xiong Yu, Edward H Egelman & Stephen C West Nature Structural & Molecular Biology14, 468–474
(June 2007); doi:10.1038/nsmb1245
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article Interaction with the BRCA2 C terminus protects RAD51–DNA filaments from disassembly by BRC repeats
Owen Richard Davies & Luca Pellegrini Nature Structural & Molecular Biology14, 475–483
(June 2007); doi:10.1038/nsmb1251
| Summary | Full Text (HTML / PDF) |
news and views RAD51, BRCA2 and DNA repair: a partial resolution
Christopher J Lord & Alan Ashworth Nature Structural & Molecular Biology14, 461–462
(June 2007); doi:10.1038/nsmb0607-461
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review Mechanosensitive channels in bacteria: signs of closure?
Ian R. Booth, Michelle D. Edwards, Susan Black, Ulrike Schumann & Samantha Miller Nature Reviews Microbiology5, 431–440
(June 2007); doi:10.1038/nrmicro1659
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brief communication Diarylquinolines target subunit c of mycobacterial ATP synthase
Anil Koul, Najoua Dendouga, Karen Vergauwen, Brenda Molenberghs, Luc Vranckx, Rudy Willebrords, Zorica Ristic, Holger Lill, Ismet Dorange, Jerome Guillemont, Dirk Bald & Koen Andries Nature Chemical Biology3, 323–324
(June 2007); doi:10.1038/nchembio884
| Summary | Full Text (HTML / PDF) |
review Metabolism, cytoskeleton and cellular signalling in the grip of protein Nε — and O-acetylation
Xiang-Jiao Yang & Serge Grégoire EMBO Reports8, 556–562
(June 2007); doi:10.1038/sj.embor.7400977
| Summary | Full Text (HTML / PDF) |
review SUMO junction—what's your function? New insights through SUMO-interacting motifs
Oliver Kerscher EMBO Reports8, 550–555
(June 2007); doi:10.1038/sj.embor.7400980
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article Two neurons mediate diet-restriction-induced longevity in C. elegans
Nicholas A. Bishop & Leonard Guarente Nature447, 545–549
(31 May 2007); doi:10.1038/nature05904
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article PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans
Siler H. Panowski, Suzanne Wolff, Hugo Aguilaniu, Jenni Durieux & Andrew Dillin Nature447, 550–555
(31 May 2007); doi:10.1038/nature05837
| Summary | Full Text (HTML / PDF) |
letter Universal physical responses to stretch in the living cell
Xavier Trepat, Linhong Deng, Steven S. An, Daniel Navajas, Daniel J. Tschumperlin, William T. Gerthoffer, James P. Butler & Jeffrey J. Fredberg Nature447, 592–595
(31 May 2007); doi:10.1038/nature05824
| Summary | Full Text (HTML / PDF) |
letter Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors
Brian J. Yeh, Robert J. Rutigliano, Anrica Deb, Dafna Bar-Sagi & Wendell A. Lim Nature447, 596–600
(31 May 2007); doi:10.1038/nature05851
| Summary | Full Text (HTML / PDF) |
letter The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation
Mamta Tahiliani, Pinchao Mei, Rui Fang, Thiago Leonor, Michael Rutenberg, Fumiko Shimizu, Jing Li, Anjana Rao & Yujiang Shi Nature447, 601–605
(31 May 2007); doi:10.1038/nature05823
| Summary | Full Text (HTML / PDF) |
letter 8-oxo-guanine bypass by human DNA polymerases in the presence of auxiliary proteins
Giovanni Maga, Giuseppe Villani, Emmanuele Crespan, Ursula Wimmer, Elena Ferrari, Barbara Bertocci & Ulrich Hübscher Nature447, 606–608
(31 May 2007); doi:10.1038/nature05843
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review Unravelling developmental dynamics: transient intervention and live imaging in plants
G. Venugopala Reddy, Sean P. Gordon & Elliot M. Meyerowitz Nature Reviews Molecular Cell Biology8, 491–501
(June 2007); doi:10.1038/nrm2188
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perspective Embryonic stem-cell culture as a tool for developmental cell biology
Shin-Ichi Nishikawa, Lars Martin Jakt & Takumi Era Nature Reviews Molecular Cell Biology8, 502–507
(June 2007); doi:10.1038/nrm2189
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article The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors
Hiromitsu Hara, Chitose Ishihara, Arata Takeuchi, Takayuki Imanishi, Liquan Xue, Stephan W Morris, Masanori Inui, Toshiyuki Takai, Akira Shibuya, Shinobu Saijo, Yoichiro Iwakura, Naohito Ohno, Haruhiko Koseki, Hiroki Yoshida, Josef M Penninger & Takashi Saito Nature Immunology8, 619–629
(June 2007); doi:10.1038/ni1466
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news and views All roads lead to CARD9
Marco Colonna Nature Immunology8, 554–555
(June 2007); doi:10.1038/ni0607-554
| Summary | Full Text (HTML / PDF) |
review The role of junctional adhesion molecules in vascular inflammation
Christian Weber, Line Fraemohs & Elisabetta Dejana Nature Reviews Immunology7, 467–477
(June 2007); doi:10.1038/nri2096
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review Nuclear microenvironments in biological control and cancer
Sayyed K. Zaidi, Daniel W. Young, Amjad Javed, Jitesh Pratap, Martin Montecino, Andre van Wijnen, Jane B. Lian, Janet L. Stein & Gary S. Stein Nature Reviews Cancer7, 454–463
(June 2007); doi:10.1038/nrc2149
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review Network motifs: theory and experimental approaches
Uri Alon Nature Reviews Genetics7, 450–461
(June 2007); doi:10.1038/nrg2102
| Summary | Full Text (HTML / PDF) |
article RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels
Shigeki Kiyonaka, Minoru Wakamori, Takafumi Miki, Yoshitsugu Uriu, Mio Nonaka, Haruhiko Bito, Aaron M Beedle, Emiko Mori, Yuji Hara, Michel De Waard, Motoi Kanagawa, Makoto Itakura, Masami Takahashi, Kevin P Campbell & Yasuo Mori Nature Neuroscience10, 691–701
(June 2007); doi:10.1038/nn1904
| Summary | Full Text (HTML / PDF) |
review The action potential in mammalian central neurons
Bruce P. Bean Nature Reviews Neuroscience8, 451–465
(June 2007); doi:10.1038/nrn2148
| Summary | Full Text (HTML / PDF) |
review Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections
William J. Steinbach, Jennifer L. Reedy, Robert A. Cramer, Jr, John R. Perfect & Joseph Heitman Nature Reviews Microbiology5, 418–430
(June 2007); doi:10.1038/nrmicro1680
| Summary | Full Text (HTML / PDF) |
article Probing the dynamics of O-GlcNAc glycosylation in the brain using quantitative proteomics
Nelly Khidekel, Scott B Ficarro, Peter M Clark, Marian C Bryan, Danielle L Swaney, Jessica E Rexach, Yi E Sun, Joshua J Coon, Eric C Peters & Linda C Hsieh-Wilson Nature Chemical Biology3, 339–348
(June 2007); doi:10.1038/nchembio881
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news and views A QUICk look at O-GlcNAc dynamics
Lance Wells Nature Chemical Biology3, 303–304
(June 2007); doi:10.1038/nchembio0607-303
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review N-glycan structure dictates extension of protein folding or onset of disposal
Maurizio Molinari Nature Chemical Biology3, 313–320
(June 2007); doi:10.1038/nchembio880
| Summary | Full Text (HTML / PDF) |
news and views A sugar-coated switch for cellular growth and arrest
Naoyuki Taniguchi Nature Chemical Biology3, 307–309
(June 2007); doi:10.1038/nchembio0607-307
| Full Text (HTML / PDF) |
scientific report Structural insights into a new homodimeric self-activated GTPase family
Stéphanie Gras, Valérie Chaumont, Bernard Fernandez, Philippe Carpentier, Fabienne Charrier-Savournin, Sophie Schmitt, Charles Pineau, Didier Flament, Arnaud Hecker, Patrick Forterre, Jean Armengaud & Dominique Housset EMBO Reports8, 569–575
(June 2007); doi:10.1038/sj.embor.7400958
| Summary | Full Text (HTML / PDF) |
scientific report Structural plasticity in the oestrogen receptor ligand-binding domain
Kendall W Nettles, John B Bruning, German Gil, Erin E O'Neill, Jason Nowak, Alun Hughs, Younchang Kim, Eugene R DeSombre, Robert Dilis, Robert N Hanson, Andrzej Joachimiak & Geoffrey L Greene EMBO Reports8, 563–568
(June 2007); doi:10.1038/sj.embor.7400963
| Summary | Full Text (HTML / PDF) |
